CINXE.COM

<!DOCTYPE html> <html lang="en-US"> <head> <meta charset="UTF-8" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <meta name='robots' content='max-image-preview:large' /> <style>img:is([sizes="auto" i], [sizes^="auto," i]) { contain-intrinsic-size: 3000px 1500px }</style> <script id="Cookiebot" src="https://consent.cookiebot.com/uc.js" data-cbid="7a76f8ea-5705-4ea6-a20b-4a7b7dd55e09" data-blockingmode="auto" type="text/javascript"></script> <script> var waitForTrackerCount = 0; function matomoWaitForTracker() { if (typeof _paq === 'undefined' || typeof Cookiebot === 'undefined') { if (waitForTrackerCount < 40) { setTimeout(matomoWaitForTracker, 250); waitForTrackerCount++; return; } } else { window.addEventListener('CookiebotOnAccept', function (e) { consentSet(); }); window.addEventListener('CookiebotOnDecline', function (e) { consentSet(); }) } } function consentSet() { if (Cookiebot.consent.statistics) { _paq.push(['setCookieConsentGiven']); _paq.push(['setConsentGiven']); } else { _paq.push(['forgetCookieConsentGiven']); _paq.push(['forgetConsentGiven']); } } document.addEventListener('DOMContentLoaded', matomoWaitForTracker()); </script>  <script> var _paq = window._paq = window._paq || []; /* tracker methods like "setCustomDimension" should be called before "trackPageView" */ _paq.push(["setDocumentTitle", document.domain + "/" + document.title]); _paq.push(["setDomains", ["*.admescope.com","*.admeshop.com"]]); _paq.push(["enableCrossDomainLinking"]); _paq.push(['trackPageView']); _paq.push(['enableLinkTracking']); (function() { var u="//matomo.vrolijkonline.com/"; _paq.push(['setTrackerUrl', u+'matomo.php']); _paq.push(['setSiteId', '4']); var d=document, g=d.createElement('script'), s=d.getElementsByTagName('script')[0]; g.async=true; g.src=u+'matomo.js'; s.parentNode.insertBefore(g,s); })(); </script>   <script> var _mtm = window._mtm = window._mtm || []; _mtm.push({'mtm.startTime': (new Date().getTime()), 'event': 'mtm.Start'}); var d=document, g=d.createElement('script'), s=d.getElementsByTagName('script')[0]; g.async=true; g.src='https://matomo.vrolijkonline.com/js/container_ZPGjTjeM.js'; s.parentNode.insertBefore(g,s); </script>  <meta name="google-site-verification" content="qOBvABvj0Z4f-kbeDDXhpMOHdegXVy0o-uFReU2FN4c" /> <meta name="msvalidate.01" content="6E9F9DDE9911E6187C689B2229CEE6C1" /><title>Permeability and Transporters – Admescope</title> <link rel='dns-prefetch' href='//js-eu1.hs-scripts.com' /> <link rel='dns-prefetch' href='//use.typekit.net' /> <link rel="alternate" type="application/rss+xml" title="Admescope » Feed" href="https://admescope.com/feed/" /> <link rel="alternate" type="application/rss+xml" title="Admescope » Comments Feed" href="https://admescope.com/comments/feed/" /> <script> window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/admescope.com\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.7.1"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); </script> <style id='wp-block-heading-inline-css'> h1.has-background,h2.has-background,h3.has-background,h4.has-background,h5.has-background,h6.has-background{padding:1.25em 2.375em}h1.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h1.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h2.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h2.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h3.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h3.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h4.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h4.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h5.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h5.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]),h6.has-text-align-left[style*=writing-mode]:where([style*=vertical-lr]),h6.has-text-align-right[style*=writing-mode]:where([style*=vertical-rl]){rotate:180deg} </style> <style id='wp-block-paragraph-inline-css'> .is-small-text{font-size:.875em}.is-regular-text{font-size:1em}.is-large-text{font-size:2.25em}.is-larger-text{font-size:3em}.has-drop-cap:not(:focus):first-letter{float:left;font-size:8.4em;font-style:normal;font-weight:100;line-height:.68;margin:.05em .1em 0 0;text-transform:uppercase}body.rtl .has-drop-cap:not(:focus):first-letter{float:none;margin-left:.1em}p.has-drop-cap.has-background{overflow:hidden}:root :where(p.has-background){padding:1.25em 2.375em}:where(p.has-text-color:not(.has-link-color)) a{color:inherit}p.has-text-align-left[style*="writing-mode:vertical-lr"],p.has-text-align-right[style*="writing-mode:vertical-rl"]{rotate:180deg} </style> <style id='wp-block-image-inline-css'> .wp-block-image a{display:inline-block}.wp-block-image img{box-sizing:border-box;height:auto;max-width:100%;vertical-align:bottom}@media (prefers-reduced-motion:no-preference){.wp-block-image img.hide{visibility:hidden}.wp-block-image img.show{animation:show-content-image .4s}}.wp-block-image[style*=border-radius] img,.wp-block-image[style*=border-radius]>a{border-radius:inherit}.wp-block-image.has-custom-border img{box-sizing:border-box}.wp-block-image.aligncenter{text-align:center}.wp-block-image.alignfull a,.wp-block-image.alignwide a{width:100%}.wp-block-image.alignfull img,.wp-block-image.alignwide img{height:auto;width:100%}.wp-block-image .aligncenter,.wp-block-image .alignleft,.wp-block-image .alignright,.wp-block-image.aligncenter,.wp-block-image.alignleft,.wp-block-image.alignright{display:table}.wp-block-image .aligncenter>figcaption,.wp-block-image .alignleft>figcaption,.wp-block-image .alignright>figcaption,.wp-block-image.aligncenter>figcaption,.wp-block-image.alignleft>figcaption,.wp-block-image.alignright>figcaption{caption-side:bottom;display:table-caption}.wp-block-image .alignleft{float:left;margin:.5em 1em .5em 0}.wp-block-image .alignright{float:right;margin:.5em 0 .5em 1em}.wp-block-image .aligncenter{margin-left:auto;margin-right:auto}.wp-block-image :where(figcaption){margin-bottom:1em;margin-top:.5em}.wp-block-image.is-style-circle-mask img{border-radius:9999px}@supports ((-webkit-mask-image:none) or (mask-image:none)) or (-webkit-mask-image:none){.wp-block-image.is-style-circle-mask img{border-radius:0;-webkit-mask-image:url('data:image/svg+xml;utf8,<svg viewBox="0 0 100 100" xmlns="http://www.w3.org/2000/svg"><circle cx="50" cy="50" r="50"/></svg>');mask-image:url('data:image/svg+xml;utf8,<svg viewBox="0 0 100 100" xmlns="http://www.w3.org/2000/svg"><circle cx="50" cy="50" r="50"/></svg>');mask-mode:alpha;-webkit-mask-position:center;mask-position:center;-webkit-mask-repeat:no-repeat;mask-repeat:no-repeat;-webkit-mask-size:contain;mask-size:contain}}:root :where(.wp-block-image.is-style-rounded img,.wp-block-image .is-style-rounded img){border-radius:9999px}.wp-block-image figure{margin:0}.wp-lightbox-container{display:flex;flex-direction:column;position:relative}.wp-lightbox-container img{cursor:zoom-in}.wp-lightbox-container img:hover+button{opacity:1}.wp-lightbox-container button{align-items:center;-webkit-backdrop-filter:blur(16px) saturate(180%);backdrop-filter:blur(16px) saturate(180%);background-color:#5a5a5a40;border:none;border-radius:4px;cursor:zoom-in;display:flex;height:20px;justify-content:center;opacity:0;padding:0;position:absolute;right:16px;text-align:center;top:16px;transition:opacity .2s ease;width:20px;z-index:100}.wp-lightbox-container button:focus-visible{outline:3px auto #5a5a5a40;outline:3px auto -webkit-focus-ring-color;outline-offset:3px}.wp-lightbox-container button:hover{cursor:pointer;opacity:1}.wp-lightbox-container button:focus{opacity:1}.wp-lightbox-container button:focus,.wp-lightbox-container button:hover,.wp-lightbox-container button:not(:hover):not(:active):not(.has-background){background-color:#5a5a5a40;border:none}.wp-lightbox-overlay{box-sizing:border-box;cursor:zoom-out;height:100vh;left:0;overflow:hidden;position:fixed;top:0;visibility:hidden;width:100%;z-index:100000}.wp-lightbox-overlay .close-button{align-items:center;cursor:pointer;display:flex;justify-content:center;min-height:40px;min-width:40px;padding:0;position:absolute;right:calc(env(safe-area-inset-right) + 16px);top:calc(env(safe-area-inset-top) + 16px);z-index:5000000}.wp-lightbox-overlay .close-button:focus,.wp-lightbox-overlay .close-button:hover,.wp-lightbox-overlay .close-button:not(:hover):not(:active):not(.has-background){background:none;border:none}.wp-lightbox-overlay .lightbox-image-container{height:var(--wp--lightbox-container-height);left:50%;overflow:hidden;position:absolute;top:50%;transform:translate(-50%,-50%);transform-origin:top left;width:var(--wp--lightbox-container-width);z-index:9999999999}.wp-lightbox-overlay .wp-block-image{align-items:center;box-sizing:border-box;display:flex;height:100%;justify-content:center;margin:0;position:relative;transform-origin:0 0;width:100%;z-index:3000000}.wp-lightbox-overlay .wp-block-image img{height:var(--wp--lightbox-image-height);min-height:var(--wp--lightbox-image-height);min-width:var(--wp--lightbox-image-width);width:var(--wp--lightbox-image-width)}.wp-lightbox-overlay .wp-block-image figcaption{display:none}.wp-lightbox-overlay button{background:none;border:none}.wp-lightbox-overlay .scrim{background-color:#fff;height:100%;opacity:.9;position:absolute;width:100%;z-index:2000000}.wp-lightbox-overlay.active{animation:turn-on-visibility .25s both;visibility:visible}.wp-lightbox-overlay.active img{animation:turn-on-visibility .35s both}.wp-lightbox-overlay.show-closing-animation:not(.active){animation:turn-off-visibility .35s both}.wp-lightbox-overlay.show-closing-animation:not(.active) img{animation:turn-off-visibility .25s both}@media (prefers-reduced-motion:no-preference){.wp-lightbox-overlay.zoom.active{animation:none;opacity:1;visibility:visible}.wp-lightbox-overlay.zoom.active .lightbox-image-container{animation:lightbox-zoom-in .4s}.wp-lightbox-overlay.zoom.active .lightbox-image-container img{animation:none}.wp-lightbox-overlay.zoom.active .scrim{animation:turn-on-visibility .4s forwards}.wp-lightbox-overlay.zoom.show-closing-animation:not(.active){animation:none}.wp-lightbox-overlay.zoom.show-closing-animation:not(.active) .lightbox-image-container{animation:lightbox-zoom-out .4s}.wp-lightbox-overlay.zoom.show-closing-animation:not(.active) .lightbox-image-container img{animation:none}.wp-lightbox-overlay.zoom.show-closing-animation:not(.active) .scrim{animation:turn-off-visibility .4s forwards}}@keyframes show-content-image{0%{visibility:hidden}99%{visibility:hidden}to{visibility:visible}}@keyframes turn-on-visibility{0%{opacity:0}to{opacity:1}}@keyframes turn-off-visibility{0%{opacity:1;visibility:visible}99%{opacity:0;visibility:visible}to{opacity:0;visibility:hidden}}@keyframes lightbox-zoom-in{0%{transform:translate(calc((-100vw + var(--wp--lightbox-scrollbar-width))/2 + var(--wp--lightbox-initial-left-position)),calc(-50vh + var(--wp--lightbox-initial-top-position))) scale(var(--wp--lightbox-scale))}to{transform:translate(-50%,-50%) scale(1)}}@keyframes lightbox-zoom-out{0%{transform:translate(-50%,-50%) scale(1);visibility:visible}99%{visibility:visible}to{transform:translate(calc((-100vw + var(--wp--lightbox-scrollbar-width))/2 + var(--wp--lightbox-initial-left-position)),calc(-50vh + var(--wp--lightbox-initial-top-position))) scale(var(--wp--lightbox-scale));visibility:hidden}} </style> <style id='wp-block-image-theme-inline-css'> :root :where(.wp-block-image figcaption){color:#555;font-size:13px;text-align:center}.is-dark-theme :root :where(.wp-block-image figcaption){color:#ffffffa6}.wp-block-image{margin:0 0 1em} </style> <style id='wp-block-spacer-inline-css'> .wp-block-spacer{clear:both} </style> <style id='wp-block-separator-inline-css'> @charset "UTF-8";.wp-block-separator{border:none;border-top:2px solid}:root :where(.wp-block-separator.is-style-dots){height:auto;line-height:1;text-align:center}:root :where(.wp-block-separator.is-style-dots):before{color:currentColor;content:"路路路";font-family:serif;font-size:1.5em;letter-spacing:2em;padding-left:2em}.wp-block-separator.is-style-dots{background:none!important;border:none!important} </style> <style id='wp-block-separator-theme-inline-css'> .wp-block-separator.has-css-opacity{opacity:.4}.wp-block-separator{border:none;border-bottom:2px solid;margin-left:auto;margin-right:auto}.wp-block-separator.has-alpha-channel-opacity{opacity:1}.wp-block-separator:not(.is-style-wide):not(.is-style-dots){width:100px}.wp-block-separator.has-background:not(.is-style-dots){border-bottom:none;height:1px}.wp-block-separator.has-background:not(.is-style-wide):not(.is-style-dots){height:2px} </style> <style id='wp-block-list-inline-css'> ol,ul{box-sizing:border-box}:root :where(.wp-block-list.has-background){padding:1.25em 2.375em} </style> <style id='wp-block-button-inline-css'> .wp-block-button__link{box-sizing:border-box;cursor:pointer;display:inline-block;text-align:center;word-break:break-word}.wp-block-button__link.aligncenter{text-align:center}.wp-block-button__link.alignright{text-align:right}:where(.wp-block-button__link){border-radius:9999px;box-shadow:none;padding:calc(.667em + 2px) calc(1.333em + 2px);text-decoration:none}.wp-block-button[style*=text-decoration] .wp-block-button__link{text-decoration:inherit}.wp-block-buttons>.wp-block-button.has-custom-width{max-width:none}.wp-block-buttons>.wp-block-button.has-custom-width .wp-block-button__link{width:100%}.wp-block-buttons>.wp-block-button.has-custom-font-size .wp-block-button__link{font-size:inherit}.wp-block-buttons>.wp-block-button.wp-block-button__width-25{width:calc(25% - var(--wp--style--block-gap, .5em)*.75)}.wp-block-buttons>.wp-block-button.wp-block-button__width-50{width:calc(50% - var(--wp--style--block-gap, .5em)*.5)}.wp-block-buttons>.wp-block-button.wp-block-button__width-75{width:calc(75% - var(--wp--style--block-gap, .5em)*.25)}.wp-block-buttons>.wp-block-button.wp-block-button__width-100{flex-basis:100%;width:100%}.wp-block-buttons.is-vertical>.wp-block-button.wp-block-button__width-25{width:25%}.wp-block-buttons.is-vertical>.wp-block-button.wp-block-button__width-50{width:50%}.wp-block-buttons.is-vertical>.wp-block-button.wp-block-button__width-75{width:75%}.wp-block-button.is-style-squared,.wp-block-button__link.wp-block-button.is-style-squared{border-radius:0}.wp-block-button.no-border-radius,.wp-block-button__link.no-border-radius{border-radius:0!important}:root :where(.wp-block-button .wp-block-button__link.is-style-outline),:root :where(.wp-block-button.is-style-outline>.wp-block-button__link){border:2px solid;padding:.667em 1.333em}:root :where(.wp-block-button .wp-block-button__link.is-style-outline:not(.has-text-color)),:root :where(.wp-block-button.is-style-outline>.wp-block-button__link:not(.has-text-color)){color:currentColor}:root :where(.wp-block-button .wp-block-button__link.is-style-outline:not(.has-background)),:root :where(.wp-block-button.is-style-outline>.wp-block-button__link:not(.has-background)){background-color:initial;background-image:none} </style> <style id='wp-block-buttons-inline-css'> .wp-block-buttons.is-vertical{flex-direction:column}.wp-block-buttons.is-vertical>.wp-block-button:last-child{margin-bottom:0}.wp-block-buttons>.wp-block-button{display:inline-block;margin:0}.wp-block-buttons.is-content-justification-left{justify-content:flex-start}.wp-block-buttons.is-content-justification-left.is-vertical{align-items:flex-start}.wp-block-buttons.is-content-justification-center{justify-content:center}.wp-block-buttons.is-content-justification-center.is-vertical{align-items:center}.wp-block-buttons.is-content-justification-right{justify-content:flex-end}.wp-block-buttons.is-content-justification-right.is-vertical{align-items:flex-end}.wp-block-buttons.is-content-justification-space-between{justify-content:space-between}.wp-block-buttons.aligncenter{text-align:center}.wp-block-buttons:not(.is-content-justification-space-between,.is-content-justification-right,.is-content-justification-left,.is-content-justification-center) .wp-block-button.aligncenter{margin-left:auto;margin-right:auto;width:100%}.wp-block-buttons[style*=text-decoration] .wp-block-button,.wp-block-buttons[style*=text-decoration] .wp-block-button__link{text-decoration:inherit}.wp-block-buttons.has-custom-font-size .wp-block-button__link{font-size:inherit}.wp-block-button.aligncenter{text-align:center} </style> <style id='wp-block-site-logo-inline-css'> .wp-block-site-logo{box-sizing:border-box;line-height:0}.wp-block-site-logo a{display:inline-block;line-height:0}.wp-block-site-logo.is-default-size img{height:auto;width:120px}.wp-block-site-logo img{height:auto;max-width:100%}.wp-block-site-logo a,.wp-block-site-logo img{border-radius:inherit}.wp-block-site-logo.aligncenter{margin-left:auto;margin-right:auto;text-align:center}:root :where(.wp-block-site-logo.is-style-rounded){border-radius:9999px} </style> <style id='wp-block-group-inline-css'> .wp-block-group{box-sizing:border-box}:where(.wp-block-group.wp-block-group-is-layout-constrained){position:relative} </style> <style id='wp-block-group-theme-inline-css'> :where(.wp-block-group.has-background){padding:1.25em 2.375em} </style> <style id='wp-block-template-part-theme-inline-css'> :root :where(.wp-block-template-part.has-background){margin-bottom:0;margin-top:0;padding:1.25em 2.375em} </style> <style id='wp-block-post-content-inline-css'> .wp-block-post-content{display:flow-root} </style> <style id='wp-block-library-inline-css'> :root{--wp-admin-theme-color:#007cba;--wp-admin-theme-color--rgb:0,124,186;--wp-admin-theme-color-darker-10:#006ba1;--wp-admin-theme-color-darker-10--rgb:0,107,161;--wp-admin-theme-color-darker-20:#005a87;--wp-admin-theme-color-darker-20--rgb:0,90,135;--wp-admin-border-width-focus:2px;--wp-block-synced-color:#7a00df;--wp-block-synced-color--rgb:122,0,223;--wp-bound-block-color:var(--wp-block-synced-color)}@media (min-resolution:192dpi){:root{--wp-admin-border-width-focus:1.5px}}.wp-element-button{cursor:pointer}:root{--wp--preset--font-size--normal:16px;--wp--preset--font-size--huge:42px}:root .has-very-light-gray-background-color{background-color:#eee}:root .has-very-dark-gray-background-color{background-color:#313131}:root .has-very-light-gray-color{color:#eee}:root .has-very-dark-gray-color{color:#313131}:root .has-vivid-green-cyan-to-vivid-cyan-blue-gradient-background{background:linear-gradient(135deg,#00d084,#0693e3)}:root .has-purple-crush-gradient-background{background:linear-gradient(135deg,#34e2e4,#4721fb 50%,#ab1dfe)}:root .has-hazy-dawn-gradient-background{background:linear-gradient(135deg,#faaca8,#dad0ec)}:root .has-subdued-olive-gradient-background{background:linear-gradient(135deg,#fafae1,#67a671)}:root .has-atomic-cream-gradient-background{background:linear-gradient(135deg,#fdd79a,#004a59)}:root .has-nightshade-gradient-background{background:linear-gradient(135deg,#330968,#31cdcf)}:root .has-midnight-gradient-background{background:linear-gradient(135deg,#020381,#2874fc)}.has-regular-font-size{font-size:1em}.has-larger-font-size{font-size:2.625em}.has-normal-font-size{font-size:var(--wp--preset--font-size--normal)}.has-huge-font-size{font-size:var(--wp--preset--font-size--huge)}.has-text-align-center{text-align:center}.has-text-align-left{text-align:left}.has-text-align-right{text-align:right}#end-resizable-editor-section{display:none}.aligncenter{clear:both}.items-justified-left{justify-content:flex-start}.items-justified-center{justify-content:center}.items-justified-right{justify-content:flex-end}.items-justified-space-between{justify-content:space-between}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#ddd;clip:auto!important;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}html :where(.has-border-color){border-style:solid}html :where([style*=border-top-color]){border-top-style:solid}html :where([style*=border-right-color]){border-right-style:solid}html :where([style*=border-bottom-color]){border-bottom-style:solid}html :where([style*=border-left-color]){border-left-style:solid}html :where([style*=border-width]){border-style:solid}html :where([style*=border-top-width]){border-top-style:solid}html :where([style*=border-right-width]){border-right-style:solid}html :where([style*=border-bottom-width]){border-bottom-style:solid}html :where([style*=border-left-width]){border-left-style:solid}html :where(img[class*=wp-image-]){height:auto;max-width:100%}:where(figure){margin:0 0 1em}html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:var(--wp-admin--admin-bar--height,0px)}@media screen and (max-width:600px){html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:0px}} </style> <style id='global-styles-inline-css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--color--symeres-primary: #923189;--wp--preset--color--symeres-secondary: #00a5c8;--wp--preset--color--symeres-font: #081f2d;--wp--preset--color--symeres-grey: #f3f4f5;--wp--preset--color--symeres-white: #FFF;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--font-family--gibson: canada-type-gibson, sans-serif;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:root { --wp--style--global--content-size: 1024px;--wp--style--global--wide-size: 1320px; }:where(body) { margin: 0; }.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }.wp-site-blocks > .alignright { float: right; margin-left: 2em; }.wp-site-blocks > .aligncenter { justify-content: center; margin-left: auto; margin-right: auto; }:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}.is-layout-flow > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-flow > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-flow > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-constrained > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-constrained > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > :where(:not(.alignleft):not(.alignright):not(.alignfull)){max-width: var(--wp--style--global--content-size);margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignwide{max-width: var(--wp--style--global--wide-size);}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}body{font-family: var(--wp--preset--font-family--gibson);font-size: 1rem;font-weight: 200;line-height: 1.6;padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}a:where(:not(.wp-element-button)){text-decoration: underline;}h1{font-family: var(--wp--preset--font-family--gibson);font-size: 2.4rem;font-weight: 600;line-height: 1.6;}h2{font-family: var(--wp--preset--font-family--gibson);font-size: 2.1rem;font-weight: 600;line-height: 1.6;}h3{font-family: var(--wp--preset--font-family--gibson);font-size: 1.8rem;font-weight: 600;line-height: 1.6;}h4{font-family: var(--wp--preset--font-family--gibson);font-size: 1.4rem;font-weight: 600;line-height: 1.6;}h5{font-family: var(--wp--preset--font-family--gibson);font-size: 1.2rem;font-weight: 600;line-height: 1.6;}h6{font-family: var(--wp--preset--font-family--gibson);font-size: 1rem;font-weight: 600;line-height: 1.6;}:root :where(.wp-element-button, .wp-block-button__link){background-color: #32373c;border-width: 0;color: #fff;font-family: inherit;font-size: inherit;line-height: inherit;padding: calc(0.667em + 2px) calc(1.333em + 2px);text-decoration: none;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-symeres-primary-color{color: var(--wp--preset--color--symeres-primary) !important;}.has-symeres-secondary-color{color: var(--wp--preset--color--symeres-secondary) !important;}.has-symeres-font-color{color: var(--wp--preset--color--symeres-font) !important;}.has-symeres-grey-color{color: var(--wp--preset--color--symeres-grey) !important;}.has-symeres-white-color{color: var(--wp--preset--color--symeres-white) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-symeres-primary-background-color{background-color: var(--wp--preset--color--symeres-primary) !important;}.has-symeres-secondary-background-color{background-color: var(--wp--preset--color--symeres-secondary) !important;}.has-symeres-font-background-color{background-color: var(--wp--preset--color--symeres-font) !important;}.has-symeres-grey-background-color{background-color: var(--wp--preset--color--symeres-grey) !important;}.has-symeres-white-background-color{background-color: var(--wp--preset--color--symeres-white) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-symeres-primary-border-color{border-color: var(--wp--preset--color--symeres-primary) !important;}.has-symeres-secondary-border-color{border-color: var(--wp--preset--color--symeres-secondary) !important;}.has-symeres-font-border-color{border-color: var(--wp--preset--color--symeres-font) !important;}.has-symeres-grey-border-color{border-color: var(--wp--preset--color--symeres-grey) !important;}.has-symeres-white-border-color{border-color: var(--wp--preset--color--symeres-white) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;}.has-gibson-font-family{font-family: var(--wp--preset--font-family--gibson) !important;} </style> <style id='block-style-variation-styles-inline-css'> :root :where(.wp-block-button.is-style-outline--1 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--2 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--3 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--4 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--5 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--6 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--7 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} :root :where(.wp-block-button.is-style-outline--8 .wp-block-button__link){background: transparent none;border-color: currentColor;border-width: 2px;border-style: solid;color: currentColor;padding-top: 0.667em;padding-right: 1.33em;padding-bottom: 0.667em;padding-left: 1.33em;} </style> <style id='wp-emoji-styles-inline-css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <style id='core-block-supports-inline-css'> .wp-container-core-buttons-is-layout-1{justify-content:flex-start;}.wp-container-core-buttons-is-layout-2{justify-content:flex-start;}.wp-container-core-buttons-is-layout-6{justify-content:flex-start;}.wp-container-core-buttons-is-layout-7{justify-content:flex-start;}.wp-container-core-buttons-is-layout-8{justify-content:flex-start;}.wp-container-core-buttons-is-layout-9{justify-content:flex-start;}.wp-container-core-buttons-is-layout-13{justify-content:flex-start;}.wp-container-core-buttons-is-layout-14{justify-content:flex-start;} </style> <style id='wp-block-template-skip-link-inline-css'> .skip-link.screen-reader-text { border: 0; clip: rect(1px,1px,1px,1px); clip-path: inset(50%); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute !important; width: 1px; word-wrap: normal !important; } .skip-link.screen-reader-text:focus { background-color: #eee; clip: auto !important; clip-path: none; color: #444; display: block; font-size: 1em; height: auto; left: 5px; line-height: normal; padding: 15px 23px 14px; text-decoration: none; top: 5px; width: auto; z-index: 100000; } </style> <link rel='stylesheet' id='custom-typekit-css-css' href='https://use.typekit.net/ihc1cix.css?ver=1.0.18' media='all' /> <link rel='stylesheet' id='megamenu-css' href='https://admescope.com/wp-content/uploads/sites/2/maxmegamenu/style.css?ver=3985df' media='all' /> <link rel='stylesheet' id='dashicons-css' href='https://admescope.com/wp-includes/css/dashicons.min.css?ver=6.7.1' media='all' /> <link rel='stylesheet' id='symeres-style-css' href='https://admescope.com/wp-content/themes/symeres-2023/style.css?ver=6.7.1' media='all' /> <link rel='stylesheet' id='symeres-screen-css' href='https://admescope.com/wp-content/themes/symeres-2023/dist/css/screen.css?ver=6.7.1' media='all' /> <script src="https://admescope.com/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script src="https://admescope.com/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script src="https://admescope.com/wp-content/themes/symeres-2023/dist/js/app.min.js?ver=6.7.1" id="symeres-js-js"></script> <link rel="https://api.w.org/" href="https://admescope.com/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://admescope.com/wp-json/wp/v2/pages/539" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://admescope.com/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.7.1" /> <link rel="canonical" href="https://admescope.com/services/permeability-and-transporters/" /> <link rel='shortlink' href='https://admescope.com/?p=539' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://admescope.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fadmescope.com%2Fservices%2Fpermeability-and-transporters%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://admescope.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fadmescope.com%2Fservices%2Fpermeability-and-transporters%2F&format=xml" />  <script class="hsq-set-content-id" data-content-id="standard-page"> var _hsq = _hsq || []; _hsq.push(["setContentType", "standard-page"]); </script>  <style class='wp-fonts-local'> @font-face{font-family:canada-type-gibson;font-style:normal;font-weight:200;font-display:fallback;src:url('https://admescope.com/wp-content/themes/symeres-2023/assets/fonts/Inter-Regular.ttf') format('truetype');} @font-face{font-family:canada-type-gibson;font-style:normal;font-weight:400;font-display:fallback;src:url('https://admescope.com/wp-content/themes/symeres-2023/assets/fonts/Inter-Bold.ttf') format('truetype');} </style> <link rel="icon" href="https://admescope.com/wp-content/uploads/sites/2/2023/03/cropped-favicon-32x32.png" sizes="32x32" /> <link rel="icon" href="https://admescope.com/wp-content/uploads/sites/2/2023/03/cropped-favicon-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://admescope.com/wp-content/uploads/sites/2/2023/03/cropped-favicon-180x180.png" /> <meta name="msapplication-TileImage" content="https://admescope.com/wp-content/uploads/sites/2/2023/03/cropped-favicon-270x270.png" /> <link rel="icon" href="" sizes="32x32"><style type="text/css">/** Mega Menu CSS: fs **/</style> <style id="wpforms-css-vars-root"> :root { --wpforms-field-border-radius: 3px; --wpforms-field-border-style: solid; --wpforms-field-border-size: 1px; --wpforms-field-background-color: #ffffff; --wpforms-field-border-color: rgba( 0, 0, 0, 0.25 ); --wpforms-field-border-color-spare: rgba( 0, 0, 0, 0.25 ); --wpforms-field-text-color: rgba( 0, 0, 0, 0.7 ); --wpforms-field-menu-color: #ffffff; --wpforms-label-color: rgba( 0, 0, 0, 0.85 ); --wpforms-label-sublabel-color: rgba( 0, 0, 0, 0.55 ); --wpforms-label-error-color: #d63637; --wpforms-button-border-radius: 3px; --wpforms-button-border-style: none; --wpforms-button-border-size: 1px; --wpforms-button-background-color: #066aab; --wpforms-button-border-color: #066aab; --wpforms-button-text-color: #ffffff; --wpforms-page-break-color: #066aab; --wpforms-background-image: none; --wpforms-background-position: center center; --wpforms-background-repeat: no-repeat; --wpforms-background-size: cover; --wpforms-background-width: 100px; --wpforms-background-height: 100px; --wpforms-background-color: rgba( 0, 0, 0, 0 ); --wpforms-background-url: none; --wpforms-container-padding: 0px; --wpforms-container-border-style: none; --wpforms-container-border-width: 1px; --wpforms-container-border-color: #000000; --wpforms-container-border-radius: 3px; --wpforms-field-size-input-height: 43px; --wpforms-field-size-input-spacing: 15px; --wpforms-field-size-font-size: 16px; --wpforms-field-size-line-height: 19px; --wpforms-field-size-padding-h: 14px; --wpforms-field-size-checkbox-size: 16px; --wpforms-field-size-sublabel-spacing: 5px; --wpforms-field-size-icon-size: 1; --wpforms-label-size-font-size: 16px; --wpforms-label-size-line-height: 19px; --wpforms-label-size-sublabel-font-size: 14px; --wpforms-label-size-sublabel-line-height: 17px; --wpforms-button-size-font-size: 17px; --wpforms-button-size-height: 41px; --wpforms-button-size-padding-h: 15px; --wpforms-button-size-margin-top: 10px; --wpforms-container-shadow-size-box-shadow: none; } </style></head> <body class="page-template-default page page-id-539 page-child parent-pageid-92 wp-custom-logo wp-embed-responsive mega-menu-max-mega-menu-1"> <div class="wp-site-blocks"><header class="header wp-block-template-part"> <div class="wp-block-group header__content is-layout-flow wp-block-group-is-layout-flow"><div class="header__logo wp-block-site-logo"><a href="https://admescope.com/" class="custom-logo-link" rel="home"><img width="240" height="55" src="https://admescope.com/wp-content/uploads/sites/2/2023/06/logo-admescope-2023.svg" class="custom-logo" alt="Admescope" decoding="async" /></a></div> <div id="mega-menu-wrap-max_mega_menu_1" class="mega-menu-wrap"><div class="mega-menu-toggle"><div class="mega-toggle-blocks-left"></div><div class="mega-toggle-blocks-center"></div><div class="mega-toggle-blocks-right"><div class='mega-toggle-block mega-menu-toggle-animated-block mega-toggle-block-0' id='mega-toggle-block-0'><button aria-label="Toggle Menu" class="mega-toggle-animated mega-toggle-animated-slider" type="button" aria-expanded="false"> <span class="mega-toggle-animated-box"> <span class="mega-toggle-animated-inner"></span> </span> </button></div></div></div><ul id="mega-menu-max_mega_menu_1" class="mega-menu max-mega-menu mega-menu-horizontal mega-no-js" data-event="hover_intent" data-effect="fade_up" data-effect-speed="200" data-effect-mobile="disabled" data-effect-speed-mobile="0" data-mobile-force-width="body" data-second-click="go" data-document-click="collapse" data-vertical-behaviour="standard" data-breakpoint="1230" data-unbind="true" data-mobile-state="collapse_all" data-mobile-direction="vertical" data-hover-intent-timeout="300" data-hover-intent-interval="100"><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-align-bottom-left mega-menu-flyout mega-disable-link mega-menu-item-106' id='mega-menu-item-106'><a class="mega-menu-link" tabindex="0" aria-expanded="false" role="button">About us<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-528' id='mega-menu-item-528'><a class="mega-menu-link" href="https://admescope.com/who-we-are/">Who We Are</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-527' id='mega-menu-item-527'><a class="mega-menu-link" href="https://admescope.com/specialized-and-skilled-team/">Specialized and Skilled Team</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-526' id='mega-menu-item-526'><a class="mega-menu-link" href="https://admescope.com/flexible-adme-tox-services/">Flexible ADME-Tox Services</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-524' id='mega-menu-item-524'><a class="mega-menu-link" href="https://admescope.com/vision-mission-and-core-values/">Vision, Mission and Core Values</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-4132' id='mega-menu-item-4132'><a class="mega-menu-link" href="https://admescope.com/quality/">Quality</a></li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-current-page-ancestor mega-current-menu-ancestor mega-current-menu-parent mega-current-page-parent mega-current_page_parent mega-current_page_ancestor mega-menu-item-has-children mega-align-bottom-left mega-menu-flyout mega-disable-link mega-menu-item-109' id='mega-menu-item-109'><a class="mega-menu-link" tabindex="0" aria-expanded="false" role="button">Services<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-582' id='mega-menu-item-582'><a class="mega-menu-link" href="https://admescope.com/services/in-vitro-metabolism/">In vitro Metabolism</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-583' id='mega-menu-item-583'><a class="mega-menu-link" href="https://admescope.com/services/safety-metabolism/">Safety Metabolism</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-584' id='mega-menu-item-584'><a class="mega-menu-link" href="https://admescope.com/services/in-vivo-dmpk/">In vivo DMPK</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-585' id='mega-menu-item-585'><a class="mega-menu-link" href="https://admescope.com/services/drug-interactions/">Drug Interactions</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-581' id='mega-menu-item-581'><a class="mega-menu-link" href="https://admescope.com/services/quantitative-bioanalysis/">Quantitative Bioanalysis</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-current-menu-item mega-page_item mega-page-item-539 mega-current_page_item mega-menu-item-580' id='mega-menu-item-580'><a class="mega-menu-link" href="https://admescope.com/services/permeability-and-transporters/" aria-current="page">Permeability and Transporters</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-579' id='mega-menu-item-579'><a class="mega-menu-link" href="https://admescope.com/services/physicochemistry-and-binding/">Physicochemistry and Binding</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-578' id='mega-menu-item-578'><a class="mega-menu-link" href="https://admescope.com/services/in-vitro-toxicology/">In vitro Toxicology</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-577' id='mega-menu-item-577'><a class="mega-menu-link" href="https://admescope.com/services/biologics/">Biologics</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-4208' id='mega-menu-item-4208'><a class="mega-menu-link" href="https://admescope.com/services/early-adme/">Early ADME</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-576' id='mega-menu-item-576'><a class="mega-menu-link" href="https://admescope.com/services/custom-services/">Custom Services</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-575' id='mega-menu-item-575'><a class="mega-menu-link" href="https://admescope.com/services/our-analytical-equipment/">Our Analytical Equipment</a></li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-align-bottom-left mega-menu-flyout mega-disable-link mega-menu-item-108' id='mega-menu-item-108'><a class="mega-menu-link" tabindex="0" aria-expanded="false" role="button">What鈥檚 new<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-572' id='mega-menu-item-572'><a class="mega-menu-link" href="https://admescope.com/blogs/">Blog</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-571' id='mega-menu-item-571'><a class="mega-menu-link" href="https://admescope.com/coming-events/">Coming Events</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-573' id='mega-menu-item-573'><a class="mega-menu-link" href="https://admescope.com/news/">News</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-4742' id='mega-menu-item-4742'><a class="mega-menu-link" href="https://admescope.com/subscribe-to-newsletter/">Subscribe to newsletter</a></li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-align-bottom-left mega-menu-flyout mega-disable-link mega-menu-item-107' id='mega-menu-item-107'><a class="mega-menu-link" tabindex="0" aria-expanded="false" role="button">Material Portal<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-567' id='mega-menu-item-567'><a class="mega-menu-link" href="https://admescope.com/videos/">Videos</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-568' id='mega-menu-item-568'><a class="mega-menu-link" href="https://admescope.com/e-books/">E-Books</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-569' id='mega-menu-item-569'><a class="mega-menu-link" href="https://admescope.com/posters/">Posters</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2260' id='mega-menu-item-2260'><a class="mega-menu-link" href="https://admescope.com/factsheets-2/">Factsheets</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-4741' id='mega-menu-item-4741'><a class="mega-menu-link" href="https://admescope.com/white-papers/">White papers</a></li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-align-bottom-left mega-menu-flyout mega-menu-item-574' id='mega-menu-item-574'><a class="mega-menu-link" href="https://admescope.com/symeres/" tabindex="0">Symeres</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-align-bottom-left mega-menu-flyout mega-menu-item-525' id='mega-menu-item-525'><a class="mega-menu-link" href="https://admescope.com/careers/" tabindex="0">Careers</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-align-bottom-left mega-menu-flyout mega-menu-item-105' id='mega-menu-item-105'><a class="mega-menu-link" href="https://admescope.com/contact-us/" tabindex="0">Contact us</a></li><li class='mega-header__button mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-align-bottom-left mega-menu-flyout mega-menu-item-4412 header__button' id='mega-menu-item-4412'><a class="mega-menu-link" href="https://admeshop.com/" tabindex="0">Admeshop</a></li></ul></div> <div class="wp-block-group header__search is-layout-flow wp-block-group-is-layout-flow"> <div class="search"> <form action="/" method="get" class="search__form"> <input class="search__qry" id="searchright" type="search" name="s" placeholder="Search"> <label class="search__button" for="searchright"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Search icon</title> <use xlink:href="#icon-search"></use> </svg> </label> </form> </div>       </div> </div> </header> <div class="hero"> <div class="hero__top" style="background-image: url('https://admescope.com/wp-content/uploads/sites/2/2023/05/032-Admescope-lab.jpg');"> <div class="hero__content"> <div class="hero__heading"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-permeability&transporters"></use></svg> <h1>Permeability and Transporters</h1> </div> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#Our_services_for_Permeability_and_Transporters_research" title="Our services for Permeability and Transporters research">Our services for Permeability and Transporters research</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#Parallel_Artificial_Membrane_Permeability_Assay_PAMPA" title="Parallel Artificial Membrane Permeability Assay (PAMPA)">Parallel Artificial Membrane Permeability Assay (PAMPA)</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-3" href="#Caco-2_MDCK_Permeability" title="Caco-2 / MDCK Permeability">Caco-2 / MDCK Permeability</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-4" href="#In_vitro_permeability_assessment_for_BCS_classification" title="In vitro permeability assessment for BCS classification">In vitro permeability assessment for BCS classification</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-5" href="#Efflux_Transporters" title="Efflux Transporters">Efflux Transporters</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-6" href="#Uptake_Transporters" title="Uptake Transporters">Uptake Transporters</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Our_services_for_Permeability_and_Transporters_research"></span>Our services for Permeability and Transporters research<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">To be able to produce the aimed therapeutical effect, the drug needs to reach its target. In vitro permeability assays are used to evaluate the capability of potential drug molecules to permeate across epithelial and endothelial barriers of the body.</p> <p class="has-medium-font-size">There are number of membrane transporters, which are involved in drug absorption, distribution, and elimination. Therefore, evaluation of transporter-mediated drug-drug interactions is required by the regulatory authorities to evaluate whether the compound is a substrate or an inhibitor of various transporters.</p> <p class="has-medium-font-size">As part of our early ADME services, series of compounds can be rapidly screened with the Parallel Artificial Membrane Permeability Assay (PAMPA). The assay provides information about passive, transcellular permeability through a gastrointestinal tract lipid formulation.</p> <figure class="wp-block-image alignright size-full"><img fetchpriority="high" decoding="async" width="337" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/06/corr3.png" alt="Admescope services for Permeability and Transporters research" class="wp-image-1507" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/06/corr3.png 337w, https://admescope.com/wp-content/uploads/sites/2/2023/06/corr3-262x300.png 262w" sizes="(max-width: 337px) 100vw, 337px" /></figure> <p class="has-medium-font-size"><em>In vitro</em> permeability assays with Caco-2 or MDCK(-MDR1/BCRP) cell lines are used for evaluating both passive and active transport of drugs to blood circulation across the intestinal membranes. The Caco-2 is most often used for evaluating overall permeability and involvement of efflux-transporters or active uptake in a bidirectional experiment.</p> <p class="has-medium-font-size">The MDCK-cells are a convenient tool for assessment of efflux transporters MDR1 and BCRP (and their inhibition) as cell lines overexpressing these transporters are available.</p> <p class="has-medium-font-size">Several assays are also available for studies with individual uptake transporters to investigate whether the new drug candidate is a substrate (potential DDI victim), or an inhibitor (potential DDI perpetrator) towards drug transporters.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-text-color has-symeres-font-color has-alpha-channel-opacity has-symeres-font-background-color has-background is-style-wide" /> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Parallel_Artificial_Membrane_Permeability_Assay_PAMPA"></span>Parallel Artificial Membrane Permeability Assay (PAMPA)<span class="ez-toc-section-end"></span></h2> <ul class="wp-block-list"> <li class="has-medium-font-size"><strong>High-through put assay</strong></li> <li class="has-medium-font-size"><strong>Evaluation of passive permeation</strong></li> </ul> <p class="has-medium-font-size">As a high-throughput screening permeability assay, we offer the Parallel Artificial Membrane Permeability Assay (PAMPA). This assay is used as an in vitro model for passive, transcellular permeation. It is a fast and easy method which determines the permeability of test compounds from a donor compartment, through a lipid-infused artificial membrane into an acceptor compartment. PAMPA studies are performed using the PAMPA explorer kit (pION Inc) and the double sink protocol.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-8 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--5" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/permeability-and-transporters" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-text-color has-symeres-font-color has-alpha-channel-opacity has-symeres-font-background-color has-background is-style-wide" /> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Caco-2_MDCK_Permeability"></span>Caco-2 / MDCK Permeability<span class="ez-toc-section-end"></span></h2> <ul class="wp-block-list"> <li class="has-medium-font-size"><strong>Bi-directional Caco-2 / MDCK transport to screen for permeability and involvement of active transport</strong></li> <li class="has-medium-font-size"><strong>Evaluation of gut wall permeability</strong></li> </ul> <p class="has-medium-font-size">The use of Caco-2 cells (human colon carcinoma cell line) has become the industry standard for investigation of permeation, as these cells endogenously express a variety of transporter proteins that are present in various endothelial and epithelial barriers of the body. In addition to Caco-2, we also provide MDCK (Madin Darby canine kidney cell line) assays for investigating permeation.</p> <p class="has-medium-font-size">Caco-2 and MDCK assays are available as mono- and bidirectional, and in the presence or absence of pH gradient across the cell monolayer. These experiments are intended for evaluation of epithelial and endothelial permeability, intestinal absorption, and involvement of active transport. As a further investigation, the <a href="https://admescope.com/services/permeability-and-transporters/#Efflux_Transporters" target="_blank" rel="noreferrer noopener">efflux</a> or <a href="https://admescope.com/services/permeability-and-transporters/#Uptake_Transporters" target="_blank" rel="noreferrer noopener">uptake</a> transporter(s) involved can be identified using chemical transporter inhibitors and/or transporter specific <em>in vitro</em> models.</p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-9 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--6" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/permeability-and-transporters" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Cacoscreen-factsheet.pdf" name="download" data-filetitle="Admescope Cacoscreen factsheet" data-filename="Admescope-Cacoscreen-factsheet.pdf" data-download="2751" name="download-file" type="checkbox"> <label for="download-file-Admescope-Cacoscreen-factsheet.pdf"> Admescope Cacoscreen factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> <li> <input id="download-file-Admescope-Cacoprofile-factsheet.pdf" name="download" data-filetitle="Admescope Cacoprofile factsheet" data-filename="Admescope-Cacoprofile-factsheet.pdf" data-download="2749" name="download-file" type="checkbox"> <label for="download-file-Admescope-Cacoprofile-factsheet.pdf"> Admescope Cacoprofile factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="In_vitro_permeability_assessment_for_BCS_classification"></span><strong>In vitro permeability assessment for BCS classification</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">The Biopharmaceutics Classification System (BCS) provides a robust framework for categorizing compounds based on their in vitro solubility and permeability, enabling accurate prediction of oral drug absorption in vivo and supporting formulation strategies.</p> <p class="has-medium-font-size">To facilitate BCS classification, we offer Caco-2 permeability assessments, which are fully aligned with the ICH M9 guidance. This assay has been rigorously validated using a set of control compounds that represent diverse permeability characteristics.</p> <p class="has-medium-font-size">The ICH M9 guidance aims to streamline drug development by allowing biopharmaceutics classification of system-based biowaivers, reducing the need for in vivo bioequivalence studies. Such waivers apply to certain orally administered systemic dosage forms if the compound qualifies as BCS Class I (high solubility, high permeability) or Class III (high solubility, low permeability). If you are working on a compound that you plan to apply for a biowaiver, we can assist with solubility and in vitro dissolution studies within the <a href="https://symeres.com/services/drug-development/#Solid_State_Chemistry_and_Pre-Formulation_Research" data-type="link" data-id="https://symeres.com/services/drug-development/#Solid_State_Chemistry_and_Pre-Formulation_Research">Symeres family</a>.</p> <p class="has-medium-font-size">For more information, <a href="https://admescope.com/contact-us/" data-type="link" data-id="https://admescope.com/contact-us/">contact our team</a>!</p> <p></p> <div class="wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-fill has-gibson-font-family" style="font-size:18px"><a class="wp-block-button__link has-symeres-secondary-background-color has-background wp-element-button" href="https://admeshop.com/collections/permeability-and-transporters" style="border-radius:100px"><strong>Request a quote via our Admeshop</strong></a></div> </div> <div class="wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex"></div> <div class="wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex"></div> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Efflux_Transporters"></span>Efflux Transporters<span class="ez-toc-section-end"></span></h2> <ul class="wp-block-list"> <li class="has-medium-font-size"><strong>Differentiated MDCKII cell monolayers expressing selected drug transporter for substrate and inhibition assays</strong></li> <li class="has-medium-font-size"><strong>Vesicular transport assays for efflux transporter inhibition</strong></li> </ul> <figure class="wp-block-image alignleft size-full"><img decoding="async" width="336" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/06/corr4.png" alt="Admescope lab team members working with Efflux Transporters services" class="wp-image-1508" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/06/corr4.png 336w, https://admescope.com/wp-content/uploads/sites/2/2023/06/corr4-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></figure> <p class="has-medium-font-size">A family of ATP binding cassette (ABC) transporters is an important group of membrane transporters involved in drug absorption, distribution and elimination. Regulatory authorities (EMA, FDA) recommend investigating the potential roles of ABC superfamily members ABCB1 (MDR1, P-glycoprotein), and ABCG2 (BCRP) for transporter-mediated drug-drug interactions (DDI), by evaluating whether the new drug candidate is a substrate (potential DDI victim) or an inhibitor (potential DDI perpetrator) towards drug transporters. Additionally, evaluation of inhibition towards bile salt export pump (BSEP, ABCB11) is recommended due to safety concerns associated with inhibition of this transporter.</p> <p class="has-medium-font-size">In substrate assays the permeability of the test compound is measured through human efflux transporter expressing MDCKII cell monolayers to both directions in the presence and absence of chemical transporter inhibitor. Active transport is observed as higher apparent permeability in basolateral to apical than in apical to basolateral direction and confirmed by reduction of efflux ratio by a known chemical inhibitor and/or by a smaller efflux ratio with control cells lacking the transfected human transporter. Similarly, in the inhibition assay the impact of the test compound on active transport of a probe substrate is evaluated. Assays are conducted with ready-to-use transfected MDCKII monolayers and LC/MS/MS is used as an analytical tool.</p> <p class="has-medium-font-size">Inhibition of transporters P-gp, BCRP and BSEP can also be studied with inside-out membrane vesicles prepared from mammalian cells expressing a single human efflux transporter. The inhibition is evaluated by measuring ATP dependent vesicular uptake of a probe substrate into membrane vesicles in the presence and absence of test compound using LC/MS/MS for analysis.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-13 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--7" style="font-size:18px;font-style:normal;font-weight:400;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/permeability-and-transporters" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Effluxsubst-factsheet.pdf" name="download" data-filetitle="Admescope Effluxsubst factsheet" data-filename="Admescope-Effluxsubst-factsheet.pdf" data-download="2759" name="download-file" type="checkbox"> <label for="download-file-Admescope-Effluxsubst-factsheet.pdf"> Admescope Effluxsubst factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> <li> <input id="download-file-Admescope-Effluxinhib-factsheet.pdf" name="download" data-filetitle="Admescope Effluxinhib factsheet" data-filename="Admescope-Effluxinhib-factsheet.pdf" data-download="2760" name="download-file" type="checkbox"> <label for="download-file-Admescope-Effluxinhib-factsheet.pdf"> Admescope Effluxinhib factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> <li> <input id="download-file-Admescope-Effluxinhib-vesicle-factsheet.pdf" name="download" data-filetitle="Admescope Effluxinhib vesicle factsheet" data-filename="Admescope-Effluxinhib-vesicle-factsheet.pdf" data-download="2861" name="download-file" type="checkbox"> <label for="download-file-Admescope-Effluxinhib-vesicle-factsheet.pdf"> Admescope Effluxinhib vesicle factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Uptake_Transporters"></span>Uptake Transporters<span class="ez-toc-section-end"></span></h2> <ul class="wp-block-list"> <li class="has-medium-font-size"><strong>Substrate and inhibition assays</strong></li> <li class="has-medium-font-size"><strong>Using human embryonic kidney (HEK293) cells transiently transfected with a single human transporter</strong></li> </ul> <p class="has-medium-font-size">A family of solute carriers (SLC) is an important group of membrane transporters involved in drug absorption, distribution and elimination. Regulatory authorities (EMA, FDA) recommend investigating the potential roles of SLC superfamily members OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1 and MATE2 for <a href="https://www.admescope.com/drug-interactions/transporter-interactions.html" target="_blank" rel="noreferrer noopener">transporter-mediated drug-drug interactions</a> (DDI), by evaluating whether the new drug candidate is a substrate (potential DDI victim) or an inhibitor (potential DDI perpetrator) towards drug transporters. In addition, EMA suggests also considering investigation of OCT1, whenever <em>in vitro</em> and <em>in vivo</em> findings suggest its involvement in DDI to be anticipated.</p> <figure class="wp-block-image alignright size-full"><img decoding="async" width="337" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/06/p-3-1.png" alt="Admescope lab team employee working with substrate and inhibition assays" class="wp-image-1191" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/06/p-3-1.png 337w, https://admescope.com/wp-content/uploads/sites/2/2023/06/p-3-1-262x300.png 262w" sizes="(max-width: 337px) 100vw, 337px" /></figure> <p class="has-medium-font-size">In substrate assays the active uptake of the test compound into cells is measured directly, while transporter inhibition is evaluated by measuring the cellular uptake of a probe substrate into cells in the presence and absence of the test compound. Both assays can be tailored for screening using 1-2 concentrations or to fulfill regulatory guidelines using a more comprehensive study set-up. Assays are conducted with human embryonic kidney (HEK293) cells transiently transfected with a single human transporter and LC/MS/MS is used as an analytical tool.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-14 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--8" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/permeability-and-transporters" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Uptakesubst-factsheet.pdf" name="download" data-filetitle="Admescope Uptakesubst factsheet" data-filename="Admescope-Uptakesubst-factsheet.pdf" data-download="2794" name="download-file" type="checkbox"> <label for="download-file-Admescope-Uptakesubst-factsheet.pdf"> Admescope Uptakesubst factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> <li> <input id="download-file-Admescope-Uptakeinhib-factsheet.pdf" name="download" data-filetitle="Admescope Uptakeinhib factsheet" data-filename="Admescope-Uptakeinhib-factsheet.pdf" data-download="2795" name="download-file" type="checkbox"> <label for="download-file-Admescope-Uptakeinhib-factsheet.pdf"> Admescope Uptakeinhib factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> </div></div> <section class="block block--primary"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? Get in touch and let鈥檚 start a conversation.</strong></p> <p><a href="/contact-us/" class="button">Contact us</a></p> </div> <figure class="block__figure"> <img src="https://admescope.com/wp-content/themes/symeres-2023/dist/img/contact-image-primary.png" alt> </figure> </div> </section></main> <footer class="footer wp-block-template-part"> <div class="wp-block-group footer__top is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__content footer__content--logo is-layout-flow wp-block-group-is-layout-flow"> <figure class="wp-block-image size-large footer__logo"> <a href="https://symeres.com" title="Symeres.com"> <img decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/03/logo-admescope-white.png" alt="" class="wp-image-44"> </a> </figure> </div> <div class="wp-block-group footer__content is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"><h4>Contact</h4> <ul> <li><a href="tel:+358207429970">+358 (0) 207 429 970</a></li> <li><a href="mailto:info@admescope.com">info@admescope.com</a></li> </ul> </div> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"><h4>Customer Service</h4> <ul> <li><a href="https://admescope.com/who-we-are/">About us</a></li> <li><a href="https://admescope.com/specialized-and-skilled-team/">Meet our team</a></li> <li><a href="https://admescope.com/contact-us/">Our facilities</a></li> </ul> </div> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"><h4>Information</h4> <ul> <li><a href="https://admescope.com/careers/">Jobs at Admescope</a></li> <li><a href="https://admescope.com/privacy-policy/">Privacy Policy</a></li> <li><a href="https://admescope.com/cookies/">Cookies</a></li> </ul> </div> <div class="wp-block-group footer__block footer__block--social is-layout-flow wp-block-group-is-layout-flow"> <h4 class="wp-block-heading">Stay up-to-date by following us on social media</h4> <ul> <li> <a href=""> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title></title> <use xlink:href="#icon-"></use> </svg> </a> </li> <li> <a href="https://www.linkedin.com/company/admescope"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Follow Symeres on LinkedIn</title> <use xlink:href="#icon-linkedin"></use> </svg> </a> </li> <li> <a href="https://www.youtube.com/@Admescope"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Follow Symeres on YouTube</title> <use xlink:href="#icon-youtube"></use> </svg> </a> </li> <ul> </div> </div> </div> <div class="wp-block-group footer__bottom is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__content footer__content--bottom is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"> <p>Symeres @2024</p> </div> </div> </div> </footer> <div class="svgsprite wp-block-template-part"> <div class="svg"> <svg xmlns="http://www.w3.org/2000/svg" width="0" height="0" viewBox="0 0 100 100"> <defs> <clipPath id="hexagon" clipPathUnits="objectBoundingBox"> <path d="M0.97,0.231,0.53,0.007 a0.06,0.053,0,0,0,-0.06,0 L0.03,0.231 A0.06,0.053,0,0,0,0,0.276 v0.447 a0.06,0.053,0,0,0,0.03,0.046 l0.44,0.224 a0.06,0.053,0,0,0,0.06,0 l0.44,-0.224 A0.06,0.053,0,0,0,1,0.724 V0.276 a0.06,0.053,0,0,0,-0.03,-0.046"/> </clipPath> </defs>  <symbol id="icon-services-admetox" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M16.239 19.136a.664.664 0 0 1-.573-.327l-1.71-2.917a.655.655 0 0 1 .234-.898.664.664 0 0 1 .905.235l1.71 2.916a.654.654 0 0 1-.566.99M7.968 19.354a.659.659 0 0 1-.573-.985l1.847-3.188a.664.664 0 0 1 1.213.156.654.654 0 0 1-.065.5l-1.847 3.187a.664.664 0 0 1-.574.33M14.113 23.615h-.004l-3.752-.02a.657.657 0 0 1 .004-1.314l3.753.02a.657.657 0 0 1-.004 1.314"/><path d="m14.63 24.543-5.644-.032-3.139-5.47 3.203-5.433 6.339.036 3.139 5.47-.006.009c.442-.149.9-.243 1.365-.28-.007-.017-.01-.035-.02-.05l-3.516-6.132a.663.663 0 0 0-.572-.331l-7.103-.04h-.004a.664.664 0 0 0-.572.325l-3.588 6.09a.653.653 0 0 0-.004.657l3.518 6.128c.118.204.335.33.57.331l6.035.035v-1.313ZM23.468 18.72a4.04 4.04 0 1 0-4.07-4.04 4.055 4.055 0 0 0 4.07 4.04"/><path d="m31.896 25.772-.02.07-.045.058-.428.245v-1.643a4.576 4.576 0 0 0-4.594-4.56h-6.451a4.576 4.576 0 0 0-4.593 4.56v8.427L3.518 25.912l-.044-.044-.038-.07V9.636l.026-.078.05-.052 14.049-8.05.107-.032.118.038 14.024 8.04.057.057.026.064.003 16.148Zm-3.27 1.964-.576.33V24.91a.288.288 0 0 1 .576 0v2.826ZM18.59 24.91a.288.288 0 0 1 .576 0v8.245l-.572.328c0-3.048-.004-8.574-.004-8.574Zm14.557-16a1.71 1.71 0 0 0-.502-.57L18.364.157A1.53 1.53 0 0 0 17.659 0a1.514 1.514 0 0 0-.711.167L2.748 8.31c-.227.13-.41.324-.528.557-.137.219-.211.47-.214.729L2 25.826c.01.255.084.504.214.724.123.218.295.406.501.548l14.233 8.156c.222.109.467.163.714.157.248.005.494-.049.718-.157l14.239-8.16c.4-.277.658-.714.709-1.197V9.589a1.48 1.48 0 0 0-.183-.678l.003-.001Z"/></g> </symbol> <symbol id="icon-services-drugdevelopment" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M17.646 35.4c-.45 0-.893-.12-1.283-.345L3.282 27.49A2.575 2.575 0 0 1 2 25.267V10.134a2.576 2.576 0 0 1 1.282-2.223L16.363.344a2.563 2.563 0 0 1 2.566 0l13.08 7.567a2.576 2.576 0 0 1 1.282 2.223v15.132a2.576 2.576 0 0 1-1.281 2.223l-13.081 7.566c-.39.226-.833.345-1.283.345Zm0-33.835a.998.998 0 0 0-.5.134L4.067 9.267c-.31.18-.5.51-.5.869v15.132c0 .358.19.688.5.868l13.08 7.566a.998.998 0 0 0 1 0l13.08-7.566c.31-.18.5-.511.5-.869V10.134c0-.358-.19-.689-.5-.869L18.146 1.7a.998.998 0 0 0-.5-.134Z"/><path d="M17.165 25.793v-3.298l2.855-1.649 2.857 1.649v3.297l-2.856 1.649-2.856-1.648Zm-9.025-5.21v-3.298l2.855-1.643 2.858 1.643v3.298l-2.857 1.65-2.856-1.65Zm9.67-5.713v-3.3l2.856-1.648 2.855 1.649v3.296l-2.855 1.65-2.856-1.647Zm3.37-8.34-1.236.048.09 2.281-3.46 1.997v3.962l-2.16 1.365-2.937-1.695-.087-2.201-1.235.048.09 2.308-3.341 1.93v3.948l-1.785 1.03.618 1.07 1.73-.998 3.527 2.035 3.475-2.005 1.46.842v4.013l4.092 2.36 3.757-2.165 1.702.982.618-1.072-1.98-1.142v-3.69l-4.094-2.361-3.48 2.005-1.457-.842v-3.366l2.063-1.303 3.514 2.03 3.267-1.888 1.89 1.091.618-1.071-1.677-.97v-3.431l1.932-1.116-.62-1.071-1.843 1.063-2.96-1.708-.09-2.314Z"/></g> </symbol> <symbol id="icon-services-drugdiscovery" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M17.646 35.4c-.45 0-.893-.12-1.283-.345L3.282 27.49A2.575 2.575 0 0 1 2 25.267V10.134a2.576 2.576 0 0 1 1.282-2.223L16.363.344a2.563 2.563 0 0 1 2.566 0l13.08 7.567a2.576 2.576 0 0 1 1.282 2.223v15.132a2.576 2.576 0 0 1-1.281 2.223l-13.081 7.566c-.39.226-.833.345-1.283.345Zm0-33.835a.998.998 0 0 0-.5.134L4.067 9.267c-.31.18-.5.51-.5.869v15.132c0 .358.19.688.5.868l13.08 7.566a.998.998 0 0 0 1 0l13.08-7.566c.31-.18.5-.511.5-.869V10.134c0-.358-.19-.689-.5-.869L18.146 1.7a.998.998 0 0 0-.5-.134Z"/><path d="m25.676 25.274-4.868-4.868a6.983 6.983 0 1 0-1.322 1.218l4.92 4.918 1.27-1.268Zm-4.626-9.392a5.607 5.607 0 1 1-5.607-5.61 5.62 5.62 0 0 1 5.606 5.608l.001.002Z"/></g> </symbol> <symbol id="icon-services-syntheticchemistry" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="m24.469 21.63-4.404-6.401a2.302 2.302 0 0 1-.407-1.31v-3.916a.77.77 0 1 0 0-1.54h-4.617a.77.77 0 1 0 0 1.54v3.917c0 .468-.142.924-.406 1.31l-4.411 6.41a3.393 3.393 0 0 0-.568 2.092c.109 1.918 1.8 3.209 4.208 3.209h7.656a3.47 3.47 0 0 0 3.522-3.21 3.402 3.402 0 0 0-.573-2.1M18.357 19.1l-.063-.032c-.6-.28-1.292-.28-1.892 0l-.061.032a4.226 4.226 0 0 1-2.505 0l2.065-2.997c.443-.641.68-1.402.679-2.182v-3.917h1.54v3.917c-.002.78.235 1.54.677 2.182l2.063 3.003a4.22 4.22 0 0 1-2.504-.004"/><path d="M17.646 35.4c-.45 0-.893-.12-1.283-.345L3.282 27.49A2.575 2.575 0 0 1 2 25.267V10.134a2.576 2.576 0 0 1 1.282-2.223L16.363.344a2.563 2.563 0 0 1 2.566 0l13.08 7.567a2.576 2.576 0 0 1 1.282 2.223v15.132a2.576 2.576 0 0 1-1.281 2.223l-13.081 7.566c-.39.226-.833.345-1.283.345Zm0-33.835a.998.998 0 0 0-.5.134L4.067 9.267c-.31.18-.5.51-.5.869v15.132c0 .358.19.688.5.868l13.08 7.566a.998.998 0 0 0 1 0l13.08-7.566c.31-.18.5-.511.5-.869V10.134c0-.358-.19-.689-.5-.869L18.146 1.7a.998.998 0 0 0-.5-.134Z"/></g> </symbol>  <symbol id="icon-services-invitrometabolism" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.544.375c.864-.5 1.928-.5 2.792 0L32.48 7.977l.158.099a2.799 2.799 0 0 1 1.235 2.134l.006.187v15.209a2.798 2.798 0 0 1-1.398 2.416l-13.146 7.604c-.864.499-1.928.499-2.792 0L3.4 28.023A2.799 2.799 0 0 1 2 25.604v-15.21a2.798 2.798 0 0 1 1.398-2.416L16.544.375Zm14.937 9.333L18.335 2.105a.788.788 0 0 0-.79 0L4.398 9.708a.799.799 0 0 0-.4.689v15.205a.8.8 0 0 0 .4.69l13.147 7.603a.79.79 0 0 0 .79 0l13.147-7.603a.799.799 0 0 0 .4-.689V10.4a.8.8 0 0 0-.4-.69l.222-.386-.223.385Z"/><path d="M23.177 9.43a.65.65 0 0 1 .589.647.76.76 0 0 1-.589.721h-1.413v12.93a3.86 3.86 0 0 1-3.772 3.606h-.2a3.505 3.505 0 0 1-3.677-3.605v-12.93h-1.383a.628.628 0 0 1-.618-.685.665.665 0 0 1 .677-.684h10.386Zm-2.647 1.368h-5.18l.001 8.944h5.18l-.001-8.944Z"/> </g> </symbol> <symbol id="icon-services-safetymetabolism" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M31.48 9.708 18.335 2.105a.788.788 0 0 0-.79 0L4.398 9.708a.799.799 0 0 0-.4.689v15.205a.8.8 0 0 0 .4.69l13.147 7.603a.79.79 0 0 0 .79 0l13.147-7.603a.799.799 0 0 0 .4-.689V10.4a.8.8 0 0 0-.4-.69l.88-1.526-.882 1.525Zm1.16-1.632a2.8 2.8 0 0 1 1.24 2.32v15.21a2.798 2.798 0 0 1-1.398 2.416l-13.146 7.604c-.864.499-1.928.499-2.792 0L3.4 28.023A2.799 2.799 0 0 1 2 25.604v-15.21a2.798 2.798 0 0 1 1.398-2.416L16.544.375c.864-.5 1.928-.5 2.792 0L32.48 7.978l.158.098Z"/><path d="M26.79 16.12a3.712 3.712 0 1 1-3.712-3.683 3.697 3.697 0 0 1 3.711 3.682M30.189 27.906V24.95A4.172 4.172 0 0 0 26 20.794h-5.883a4.173 4.173 0 0 0-4.188 4.156v9.012l1.768 1.012.092.026.085-.026.637-.364v-9.293a.263.263 0 1 1 .525 0v8.648l8.1-4.638v-4.008a.263.263 0 0 1 .526 0v4.037l2.527-1.45ZM16.468 20.223a.6.6 0 0 1-.52-.3l-1.552-2.641a.6.6 0 0 1 1.039-.6l1.552 2.645a.6.6 0 0 1-.518.896M8.959 20.422a.6.6 0 0 1-.295-.084.594.594 0 0 1-.222-.814l1.673-2.888a.6.6 0 0 1 .82-.22.594.594 0 0 1 .222.815L9.48 20.122a.6.6 0 0 1-.521.3M14.538 24.288l-3.407-.019a.6.6 0 1 1 0-1.192l3.407.02a.6.6 0 1 1 0 1.191"/><path d="m15.006 25.13-5.124-.03-2.845-4.962 2.898-4.929 5.757.033 2.85 4.962-.005.01c.4-.136.817-.221 1.239-.255-.007-.015-.01-.03-.018-.044l-3.198-5.561a.6.6 0 0 0-.519-.3l-6.44-.039a.6.6 0 0 0-.52.3l-3.26 5.519a.593.593 0 0 0 0 .6l3.197 5.56a.6.6 0 0 0 .518.299l5.478.032-.008-1.195Z"/> </g> </symbol> <symbol id="icon-services-invivodmpk" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M31.502 9.715 18.347 2.106a.79.79 0 0 0-.79 0L4.4 9.716a.8.8 0 0 0-.4.689V25.62a.8.8 0 0 0 .4.69l13.157 7.61a.79.79 0 0 0 .79 0l13.157-7.61a.8.8 0 0 0 .4-.688V10.407a.8.8 0 0 0-.4-.691l.88-1.527-.882 1.526Zm1.16-1.633a2.801 2.801 0 0 1 1.242 2.323v15.22a2.8 2.8 0 0 1-1.4 2.418l-13.155 7.61c-.864.499-1.93.499-2.794 0L3.4 28.042a2.801 2.801 0 0 1-1.4-2.42v-15.22a2.8 2.8 0 0 1 1.4-2.42L16.554.376c.864-.5 1.93-.5 2.794 0l13.155 7.609.158.098Z"/><path d="M17.933 10.842c7.656 0 9.892 5.363 9.669 8.537a5.451 5.451 0 0 1-1.454 3.6 5.678 5.678 0 0 1-4.135 1.5.6.6 0 0 1-.615-.665c0-.693.559-.665.559-.665a4.781 4.781 0 0 0 3.13-1.053 4.392 4.392 0 0 0 1.118-2.606l-17.569.01a.229.229 0 0 1-.229-.093.732.732 0 0 1-.123-.49c0-3.252 2.686-8.075 9.649-8.075Zm-5.711 4.108a1.255 1.255 0 1 0 .006 2.51 1.255 1.255 0 0 0-.006-2.51Z"/> </g> </symbol> <symbol id="icon-services-druginteractions" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="M17.919 13.818a4.31 4.31 0 0 1 2.555 4.233 4.61 4.61 0 0 1-2.555 4.374 4.673 4.673 0 0 1-2.521-4.304 4.674 4.674 0 0 1 2.52-4.303"/><path d="M13.751 23.69c2.743 0 3.181-.996 3.181-.996a4.873 4.873 0 0 1-2.491-4.572 5.2 5.2 0 0 1 2.636-4.71s-.72-1.103-3.326-1.103A5.658 5.658 0 0 0 8.126 18a5.658 5.658 0 0 0 5.625 5.69M22.114 23.69c-2.743 0-3.18-.996-3.18-.996a4.873 4.873 0 0 0 2.495-4.572 5.2 5.2 0 0 0-2.636-4.71s.715-1.103 3.321-1.103A5.658 5.658 0 0 1 27.74 18a5.658 5.658 0 0 1-5.625 5.69"/> </g> </symbol> <symbol id="icon-services-quantitativeanalysis" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="M8.705 9.229V25.9a.79.79 0 0 0 .849.787.792.792 0 0 0 .848-.787V9.23a.837.837 0 0 0-.848-.788c-.637 0-.85.788-.85.788M10.968 13.523v12.45a.792.792 0 0 0 .849.788.792.792 0 0 0 .849-.788v-12.45a.836.836 0 0 0-.85-.788c-.637 0-.85.788-.85.788M13.231 24.113v1.86a.792.792 0 0 0 .849.788.792.792 0 0 0 .847-.788v-1.932a.794.794 0 0 0-.85-.716c-.636 0-.848.788-.848.788M19.349 24.113v1.86a.851.851 0 0 0 1.698 0V24.16a.819.819 0 0 0-.849-.83.792.792 0 0 0-.849.788M21.647 16.327v9.585a.851.851 0 0 0 1.697 0v-9.585a.851.851 0 0 0-1.697 0M26.245 16.17v9.745a.851.851 0 0 0 1.697 0v-9.788a.81.81 0 0 0-.85-.816.838.838 0 0 0-.848.859M23.947 18.462v7.517a.851.851 0 0 0 1.696 0v-7.517a.85.85 0 1 0-1.696 0M15.494 21.322v4.65a.792.792 0 0 0 .85.788.792.792 0 0 0 .848-.788v-4.65a.756.756 0 0 0-.849-.644.95.95 0 0 0-.849.644"/> </g> </symbol> <symbol id="icon-services-permeability&transporters" viewBox="0 0 36 36"> <g fill="none" fill-rule="evenodd"> <path fill="currentColor" fill-rule="nonzero" d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.254a2.751 2.751 0 0 1-1.376 2.376l-4.103 2.374-9.083 5.254c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .847 0l9.083-5.254 4.104-2.374a.856.856 0 0 0 .429-.738v-15.25a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path stroke="currentColor" stroke-linecap="round" stroke-width="2" d="M17.484 8.572v19.829"/><path fill="currentColor" fill-rule="nonzero" d="M10.872 14.07a1.547 1.547 0 0 0 1.543-1.55c0-.854-.69-1.546-1.543-1.548a1.547 1.547 0 0 0-1.544 1.55c0 .853.69 1.545 1.544 1.547M13.11 19.957a1.547 1.547 0 0 0 1.543-1.55c0-.853-.69-1.546-1.543-1.548a1.547 1.547 0 0 0-1.544 1.55c0 .853.69 1.546 1.544 1.548M10.872 25.844a1.547 1.547 0 0 0 1.543-1.55c0-.853-.69-1.545-1.543-1.547a1.547 1.547 0 0 0-1.544 1.55c0 .853.69 1.545 1.544 1.547M22.99 16.626a1.547 1.547 0 0 0 1.543-1.55c0-.853-.69-1.546-1.544-1.547a1.547 1.547 0 0 0-1.543 1.55c0 .853.69 1.545 1.543 1.547"/> </g> </symbol> <symbol id="icon-services-physicochemistryandbinding" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="M17.916 22.209a1.755 1.755 0 0 0 1.745-1.77c0-1.324-1.745-2.821-1.745-2.821s-1.745 1.501-1.745 2.821a1.755 1.755 0 0 0 1.745 1.77M12.494 24.415h10.843a.727.727 0 0 1 .538.22.759.759 0 0 1 .213.551.759.759 0 0 1-.212.55.727.727 0 0 1-.536.223H12.432a.696.696 0 0 1-.506-.235.726.726 0 0 1-.18-.538.759.759 0 0 1 .213-.549.727.727 0 0 1 .535-.222M13.274 4.068l3.24 4.54c.148.208.254.443.311.693.106.248.149.519.126.788v4.51h1.931v-4.51c.008-.273.071-.54.186-.788.072-.275.2-.533.374-.757l3.49-4.476 1.185.882-3.615 4.789v5.3s-.156 1.069-2.633 1.07c-2.478.003-2.477-1.07-2.477-1.07V9.68l-3.365-4.793 1.247-.82Z"/> </g> </symbol> <symbol id="icon-services-invitrotoxicology" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="m12 10.587 5.985 5.985 5.986-5.985A1 1 0 0 1 25.385 12L19.4 17.986l5.985 5.986a1 1 0 0 1-1.414 1.415L17.985 19.4 12 25.387a1 1 0 0 1-1.415-1.415l5.986-5.986L10.585 12A1 1 0 1 1 12 10.587Z"/> </g> </symbol> <symbol id="icon-services-biologics" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.305.364a2.968 2.968 0 0 1 2.849 0l13.839 7.603-.963 1.753-13.84-7.603a.969.969 0 0 0-.922 0L3.428 9.72a.785.785 0 0 0-.428.677v15.204c0 .272.159.532.428.68l13.84 7.602a.97.97 0 0 0 .923 0l13.84-7.603a.785.785 0 0 0 .428-.677V10.4a.786.786 0 0 0-.428-.679l.962-1.753a2.785 2.785 0 0 1 1.466 2.43v15.208a2.783 2.783 0 0 1-1.465 2.428l-13.84 7.603a2.97 2.97 0 0 1-2.849 0L2.466 28.034A2.785 2.785 0 0 1 1 25.604v-15.21a2.783 2.783 0 0 1 1.465-2.427L16.305.364Z"/><path d="M25.559 10.097a1 1 0 1 1 1.502 1.321l-6.847 7.783.001 10.002a1 1 0 0 1-.883.993l-.117.007a1 1 0 0 1-1-1V18.446l.25-.283 7.094-8.066Zm-16.965-.09a1 1 0 0 1 1.411.09l7.095 8.066.25.283v10.757a1 1 0 1 1-2 0L15.347 19.2l-6.844-7.782a1 1 0 0 1 .001-1.322l.09-.089Zm19.274 1.937a1 1 0 1 1 1.506 1.317l-6.566 7.503a1 1 0 1 1-1.505-1.317l6.565-7.503ZM6.285 11.85a1 1 0 0 1 1.41.094l6.566 7.503a1 1 0 1 1-1.505 1.317L6.191 13.26a1 1 0 0 1 .094-1.411Z"/> </g> </symbol>  <symbol id="icon-twitter" viewBox="0 0 100 100"> <path fill="currentColor" fill-rule="evenodd" d="m54 2.31 35.301 20.38a8 8 0 0 1 4 6.929V70.38a8 8 0 0 1-4 6.928L54 97.691a8 8 0 0 1-8 0L10.699 77.309a8 8 0 0 1-4-6.928V29.62a8 8 0 0 1 4-6.928L46 2.309a8 8 0 0 1 8 0ZM69.169 41.22A20.372 20.372 0 0 0 74 36.394c-1.73.722-3.608 1.243-5.547 1.445 1.998-1.156 3.519-2.977 4.235-5.145a19.335 19.335 0 0 1-6.114 2.254C64.814 33.128 62.31 32 59.536 32c-5.338 0-9.632 4.191-9.632 9.337 0 .722.089 1.445.238 2.139-7.992-.405-15.12-4.105-19.862-9.77a9.05 9.05 0 0 0-1.312 4.711c0 3.238 1.7 6.1 4.295 7.776a9.934 9.934 0 0 1-4.354-1.185v.115c0 4.539 3.31 8.296 7.724 9.164-.806.202-1.67.318-2.535.318-.627 0-1.223-.058-1.82-.145 1.223 3.7 4.772 6.388 9.007 6.475-3.31 2.515-7.456 3.99-11.959 3.99-.805 0-1.55-.03-2.326-.116C31.265 67.468 36.334 69 41.792 69c17.715 0 27.407-14.222 27.407-26.565 0-.405 0-.81-.03-1.214Z" /> </symbol> <symbol id="icon-linkedin" viewBox="0 0 100 100"> <path fill="currentColor" fill-rule="evenodd" d="m54 2.31 35.301 20.38a8 8 0 0 1 4 6.929V70.38a8 8 0 0 1-4 6.928L54 97.691a8 8 0 0 1-8 0L10.699 77.309a8 8 0 0 1-4-6.928V29.62a8 8 0 0 1 4-6.928L46 2.309a8 8 0 0 1 8 0ZM39.177 69V41.626h-8.5V69h8.5Zm-4.254-31.108c2.717 0 4.922-2.251 4.922-4.97a4.923 4.923 0 1 0-9.845 0c0 2.719 2.205 4.97 4.923 4.97ZM70.99 69H71V53.963c0-7.358-1.581-13.023-10.184-13.023-4.136 0-6.908 2.27-8.043 4.42h-.119v-3.734h-8.152V69h8.49V55.446c0-3.57.678-7.02 5.098-7.02 4.355 0 4.419 4.073 4.419 7.249V69h8.482Z" /> </symbol> <symbol id="icon-youtube" viewBox="0 0 100 100"> <path fill="currentColor" fill-rule="evenodd" d="m53 1.31 35.301 20.38a8 8 0 0 1 4 6.929V69.38a8 8 0 0 1-4 6.928L53 96.691a8 8 0 0 1-8 0L9.699 76.309a8 8 0 0 1-4-6.928V28.62a8 8 0 0 1 4-6.928L45 1.309a8 8 0 0 1 8 0Zm20.934 36.166c-.586-2.155-2.314-3.853-4.509-4.43C65.448 32 49.5 32 49.5 32s-15.948 0-19.925 1.047c-2.195.576-3.923 2.274-4.51 4.43C24 41.382 24 49.534 24 49.534s0 8.152 1.066 12.06c.586 2.155 2.314 3.782 4.509 4.358C33.552 67 49.5 67 49.5 67s15.948 0 19.925-1.047c2.195-.576 3.923-2.203 4.51-4.359C75 57.687 75 49.535 75 49.535s0-8.152-1.066-12.059Zm-29.65 19.46V42.135l13.33 7.402-13.33 7.4Z" /> </symbol> <symbol id="icon-arrow-down" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="M6.828 8.172a4 4 0 1 0-5.656 5.656L15.12 27.776a4 4 0 0 0 5.656 0L34.728 13.83a4 4 0 0 0-5.656-5.658l-11.124 11.12-11.12-11.12Z"/> </symbol> <symbol id="icon-arrow-hero-prev" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="M2.32 18 18.68 1.64A.96.96 0 0 0 17.32.281L.281 17.321a.96.96 0 0 0 0 1.358l17.04 17.04a.96.96 0 0 0 1.358-1.359L2.32 18Z"/> </symbol> <symbol id="icon-arrow-hero-next" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="m33.641 18-16.36 16.36a.96.96 0 1 0 1.359 1.359l17.04-17.04a.96.96 0 0 0 0-1.358L18.64.28a.96.96 0 0 0-1.359 1.359L33.641 18Z"/> </symbol> <symbol id="icon-search" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="m34.103 32.343-8.287-8.516a13.752 13.752 0 0 0 3.299-8.933C29.06 7.179 22.772.964 15.057 1 7.343.964 1.054 7.18 1 14.894c.051 7.716 6.34 13.935 14.057 13.898a14.02 14.02 0 0 0 8.054-2.514l8.349 8.577c.346.357.824.558 1.321.556.473.002.928-.18 1.271-.505a1.8 1.8 0 0 0 .05-2.563M15.058 4.626c5.701-.027 10.349 4.565 10.39 10.266-.041 5.701-4.689 10.294-10.39 10.267-5.7.027-10.349-4.566-10.39-10.267.041-5.7 4.69-10.293 10.39-10.266"/> </symbol> <symbol id="icon-hamburger" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M0 8.182h36V4.909H0zM0 19.106h36v-3.273H0zM0 30.031h36v-3.273H0z"/></g> </symbol> <symbol id="icon-vacancies-arrow" viewBox="0 0 3157 420"> <path fill="currentColor" fill-rule="nonzero" d="M3152.737 222.593a25.489 25.489 0 0 0 0-25.179L3047.491 12.589A24.774 24.774 0 0 0 3025.986.003H.328v420h3025.658a24.774 24.774 0 0 0 21.5-12.589l105.251-184.821Z"/> </symbol> <symbol id="icon-times" viewBox="0 0 320 512"> <path fill="currentColor" d="M310.6 150.6c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L160 210.7 54.6 105.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3L114.7 256 9.4 361.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0L160 301.3 265.4 406.6c12.5 12.5 32.8 12.5 45.3 0s12.5-32.8 0-45.3L205.3 256 310.6 150.6z"/> </symbol> <symbol id="icon-download-label" viewBox="0 0 118.495 104.107"> <g><path fill="currentColor" d="M118.498 0H28.874a5.428 5.428 0 0 0-4.772 3.121L.741 48.934a6.964 6.964 0 0 0 0 6.241l23.361 45.813a5.43 5.43 0 0 0 4.773 3.118h89.623"/></g> </symbol> <symbol id="icon-download" viewBox="0 0 39.946 55.06"> <path fill="currentColor" d="M39.483 12.254 29.295.636A1.866 1.866 0 0 0 27.892 0H2.159A2.159 2.159 0 0 0 0 2.159V52.9a2.159 2.159 0 0 0 2.159 2.16h35.627a2.159 2.159 0 0 0 2.16-2.16V13.484a1.866 1.866 0 0 0-.463-1.23"/> </symbol> <symbol id="icon-download-file" viewBox="0 0 180 180"> <path fill="currentColor" fill-rule="nonzero" d="M115.134 0a9.705 9.705 0 0 1 7.298 3.307l31.857 36.328.728.933a9.703 9.703 0 0 1 1.62 4.322l.066 1.168v123.316c0 5.868-4.757 10.626-10.626 10.626H34.627A10.626 10.626 0 0 1 24 169.374V10.626C24 4.758 28.758 0 34.626 0h80.508Zm-6.138 14.489H38.49v151.278h103.726V52.42l-25.967.008a7.245 7.245 0 0 1-7.195-6.4l-.049-.844-.008-30.695Zm6.138-6.75h-1.277l2.887 2.887-.008 34.055 29.349.007 2.879 2.872v-1.517a1.966 1.966 0 0 0-.22-.912l-.26-.375L116.612 8.41a1.966 1.966 0 0 0-1.478-.67Z"/> </symbol> <symbol id="downloads-checkbox-default" viewBox="0 0 180 180"> <g fill="none" fill-rule="nonzero"><path fill="#00A5C8" d="M154.075 40.06 120.769 2.083A6.096 6.096 0 0 0 116.183 0H32.059A7.059 7.059 0 0 0 25 7.059V172.94A7.059 7.059 0 0 0 32.059 180h116.47a7.059 7.059 0 0 0 7.059-7.059V44.082a6.1 6.1 0 0 0-1.515-4.016M32.06 173.226V7.06h81.766v36.114a3.529 3.529 0 0 0 3.53 3.53h31.174v126.524H32.06Z"/><path fill="#923189" d="M121.012 78.327 91.974 61.531a3.95 3.95 0 0 0-3.956 0l-29.04 16.796A3.965 3.965 0 0 0 57 81.76v33.592c0 1.415.754 2.722 1.979 3.43l29.039 16.797a3.951 3.951 0 0 0 3.956 0l29.04-16.797a3.966 3.966 0 0 0 1.976-3.432V81.76a3.965 3.965 0 0 0-1.978-3.432"/><path fill="#FFF" d="M105.121 100.732v-4.403H91.792V83h-4.404v13.329H74v4.403h13.388v13.329h4.404v-13.329z"/></g> </symbol> <symbol id="downloads-checkbox-checked" viewBox="0 0 180 180"> <g fill="none" fill-rule="nonzero"><path fill="#00A5C8" d="M154.075 40.06 120.769 2.083A6.096 6.096 0 0 0 116.183 0H32.059A7.059 7.059 0 0 0 25 7.059V172.94A7.059 7.059 0 0 0 32.059 180h116.47a7.059 7.059 0 0 0 7.059-7.059V44.082a6.1 6.1 0 0 0-1.515-4.016M32.06 173.226V7.06h81.766v36.114a3.529 3.529 0 0 0 3.53 3.53h31.174v126.524H32.06Z"/><path fill="#00A5C8" d="M121.31 78.382 92.272 61.585a3.95 3.95 0 0 0-3.955 0l-29.04 16.797a3.965 3.965 0 0 0-1.978 3.432v33.591c0 1.415.754 2.723 1.978 3.43l29.04 16.797a3.951 3.951 0 0 0 3.955 0l29.04-16.796a3.966 3.966 0 0 0 1.977-3.432v-33.59a3.965 3.965 0 0 0-1.979-3.432"/><path fill="#FFF" d="M105.121 100.732v-4.403H74v4.403z"/></g> </symbol> </svg> </div>  <script type="text/javascript" id="hs-script-loader" async defer src="//js-eu1.hs-scripts.com/25214463.js"></script>  </div></div> <section class="downloads__aside" id="sidebar-downloads"> <button class="downloads__label"> <span>0</span> <svg><use xlink:href="#icon-download"></use></svg> </button> <div class="downloads__content"> <button class="downloads__close" id="downloads-close"><svg xmlns:xlink="http://www.w3.org/1999/xlink"><title>Close this panel</title><use xlink:href="#icon-times"></use></svg></button> <div id="selected-files" class="downloads__files"> <h3>Files</h3> <div> <ul></ul> </div> <button style="margin-top:20px;" id="remove-all-files" type="submit" class="button">Remove all</button> </div> <form class="downloads__form form" action="https://admescope.com/wp-admin/admin-ajax.php" method="POST" id="symeresdownloads"> <p>Please, provide us your email address so that we can send you a link for downloading the requested files.</p> <div class="form__row"> <div class="form__col"> <label for="email">Email</label> <input id="email" name="email" type="email" placeholder="Email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#symeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#symeresdownloads'); var email = $("#symeresdownloads :input[name='email']").val(); var firstName = $("#symeresdownloads :input[name='first-name']").val(); var lastName = $("#symeresdownloads :input[name='last-name']").val(); var company = $("#symeresdownloads :input[name='company']").val(); var action = $("#symeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#symeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#symeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ jQuery('.status-msg').remove(); if (error) { jQuery('input#email').css('border-color', '#d63637'); location.reload(); } if (!error) { localStorage.removeItem('downloads'); $('.downloads__aside').css('display', 'none'); location.reload(); } }, 5000); } }); } if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } $('body').on('change', '.downloads__label span', function(){ if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } }); }); }); </script><script id="wp-block-template-skip-link-js-after"> ( function() { var skipLinkTarget = document.querySelector( 'main' ), sibling, skipLinkTargetID, skipLink; // Early exit if a skip-link target can't be located. if ( ! skipLinkTarget ) { return; } /* * Get the site wrapper. * The skip-link will be injected in the beginning of it. */ sibling = document.querySelector( '.wp-site-blocks' ); // Early exit if the root element was not found. if ( ! sibling ) { return; } // Get the skip-link target's ID, and generate one if it doesn't exist. skipLinkTargetID = skipLinkTarget.id; if ( ! skipLinkTargetID ) { skipLinkTargetID = 'wp--skip-link--target'; skipLinkTarget.id = skipLinkTargetID; } // Create the skip link. skipLink = document.createElement( 'a' ); skipLink.classList.add( 'skip-link', 'screen-reader-text' ); skipLink.href = '#' + skipLinkTargetID; skipLink.innerHTML = 'Skip to content'; // Inject the skip link. sibling.parentElement.insertBefore( skipLink, sibling ); }() ); </script> <script id="leadin-script-loader-js-js-extra"> var leadin_wordpress = {"userRole":"visitor","pageType":"page","leadinPluginVersion":"11.1.73"}; </script> <script src="https://js-eu1.hs-scripts.com/25214463.js?integration=WordPress&ver=11.1.73" id="leadin-script-loader-js-js"></script> <script src="https://admescope.com/wp-content/plugins/easy-table-of-contents/vendor/js-cookie/js.cookie.min.js?ver=2.2.1" id="ez-toc-js-cookie-js"></script> <script src="https://admescope.com/wp-content/plugins/easy-table-of-contents/vendor/sticky-kit/jquery.sticky-kit.min.js?ver=1.9.2" id="ez-toc-jquery-sticky-kit-js"></script> <script id="ez-toc-js-js-extra"> var ezTOC = {"smooth_scroll":"1","scroll_offset":"30","fallbackIcon":"<span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span>","chamomile_theme_is_on":""}; </script> <script src="https://admescope.com/wp-content/plugins/easy-table-of-contents/assets/js/front.min.js?ver=2.0.69.1-1730987172" id="ez-toc-js-js"></script> <script id="ez-toc-scroll-scriptjs-js-extra"> var eztoc_smooth_local = {"scroll_offset":"30","add_request_uri":""}; </script> <script src="https://admescope.com/wp-content/plugins/easy-table-of-contents/assets/js/smooth_scroll.min.js?ver=2.0.69.1" id="ez-toc-scroll-scriptjs-js"></script> <script src="https://admescope.com/wp-includes/js/hoverIntent.min.js?ver=1.10.2" id="hoverIntent-js"></script> <script src="https://admescope.com/wp-content/plugins/megamenu/js/maxmegamenu.js?ver=3.4.1" id="megamenu-js"></script> <style> </style> <script> document.addEventListener("DOMContentLoaded", function(event) { }); </script> <script> var accordions_active = null; var accordions_tabs_active = null; </script> </body> </html>