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toxicity</title> <meta name="description" content="Search results for: spleen toxicity"> <meta name="keywords" content="spleen toxicity"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="spleen toxicity"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1061</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: spleen toxicity</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1061</span> Protective Effect of Protocatechuic Acid Alone and in Combination with Ascorbic Acid in Aniline Hydrochloride Induced Spleen Toxicity in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aman%20Upaganlawar">Aman Upaganlawar</a>, <a href="https://publications.waset.org/abstracts/search?q=Upasana%20Khairnar"> Upasana Khairnar</a>, <a href="https://publications.waset.org/abstracts/search?q=Chandrashekhar%20Upasani"> Chandrashekhar Upasani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was designed to evaluate the protective effects of protocatechuic acid alone and in combination with ascorbic acid in aniline hydrochloride-induced spleen toxicity in rats. Male Wistar rats of either sex (200-250g) were used and divided into different groups. Spleen toxicity was induced by aniline hydrochloride (100 ppm) in drinking water for 28 days. Treatment group received protocatechuic acid (40 mg/kg/day, p.o), ascorbic acid (40 mg/kg/day, p.o), and combination of protocatechuic acid (20 mg/kg/day, p.o) and ascorbic acid (20 mg/kg/day, p.o) followed by aniline hydrochloride. At the end of treatment period, serum and tissue parameters were evaluated. Rats supplemented with aniline hydrochloride showed a significant alteration in body weight, spleen weight, feed consumption, water intake, hematological parameters (Hemoglobin content, Red Blood Cells, White Blood Cells and Total iron content), tissue parameters (Lipid peroxidation, Reduced glutathione, Nitric oxide content) compared to control group. Histopathology of aniline hydrochloride-induced spleen showed significant damage compared to control rats. Treatment with Protocatechuic acid along with ascorbic acid showed better protection as compared to protocatechuic acid or ascorbic acid alone in aniline hydrochloride-induced spleen toxicity. In conclusion Treatment with protocatechuic acid and ascorbic acid in combination showed significant protection in aniline hydrochloride-induced splenic toxicity in rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aniline" title="aniline">aniline</a>, <a href="https://publications.waset.org/abstracts/search?q=spleen%20toxicity" title=" spleen toxicity"> spleen toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=protocatechuic%20acid" title=" protocatechuic acid"> protocatechuic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=ascorbic%20acid" title=" ascorbic acid"> ascorbic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidants" title=" antioxidants"> antioxidants</a> </p> <a href="https://publications.waset.org/abstracts/52559/protective-effect-of-protocatechuic-acid-alone-and-in-combination-with-ascorbic-acid-in-aniline-hydrochloride-induced-spleen-toxicity-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52559.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1060</span> A Rare Case Report of Wandering Spleen Torsion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Steven%20Robinson">Steven Robinson</a>, <a href="https://publications.waset.org/abstracts/search?q=Adriana%20Dager"> Adriana Dager</a>, <a href="https://publications.waset.org/abstracts/search?q=Param%20Patel"> Param Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wandering spleen is a rare variant where there is abnormal development of the ligamentous peritoneal attachments of the spleen which normally anchor it in the left upper quadrant of the abdomen. Ligamentous abnormalities can be congenital, or acquired through pregnancy, injury, or iatrogenic causes. Absence or laxity of these ligaments allows migration of the spleen into ectopic portions of the abdomen, which is also associated with an elongated vascular pedicle. Incidence of wandering spleen is reported at less than 0.25% with a female to male ratio of approximately 6:1. The most common complication of a wandering spleen is torsion around its vascular pedicle which can lead to thrombosis and infarction. Torsion of a wandering spleen is a rare but important cause of an acute abdomen. Imaging, and specifically CT or ultrasound, is crucial in the diagnosis. We present a case of a torsed wandering spleen which was treated with splenectomy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wandering%20Spleen" title="Wandering Spleen">Wandering Spleen</a>, <a href="https://publications.waset.org/abstracts/search?q=Torsion" title=" Torsion"> Torsion</a>, <a href="https://publications.waset.org/abstracts/search?q=Splenic%20Torsion" title=" Splenic Torsion"> Splenic Torsion</a>, <a href="https://publications.waset.org/abstracts/search?q=Spleen" title=" Spleen"> Spleen</a> </p> <a href="https://publications.waset.org/abstracts/162557/a-rare-case-report-of-wandering-spleen-torsion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/162557.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">81</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1059</span> Gold Nanoparticle: Synthesis, Characterization, Clinico-Pathological, Pathological and Bio-Distribution Studies in Rabbits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20M.%20Bashandy">M. M. Bashandy</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20R.%20Ahmed"> A. R. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20El-Gaffary"> M. El-Gaffary</a>, <a href="https://publications.waset.org/abstracts/search?q=Sahar%20S.%20Abd%20El-Rahman"> Sahar S. Abd El-Rahman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study evaluated the acute toxicity and tissue distribution of intravenously administered gold nanoparticles (AuNPs) in male rabbits. Rabbits were exposed to single dose of AuNPs (300 µg/ kg). Toxic effects were assessed via general behavior, hematological parameters, serum biochemical parameters and histopathological examination of various rabbits’ organs. Tissue distribution of AuNPs was evaluated at a dose of 300 µg/ kg in male rabbit. Inductively coupled plasma–mass spectrometry (ICP-MS) was used to determine gold concentrations in tissue samples collected at predetermined time intervals. After one week, AuNPs exerted no obvious acute toxicity in rabbits. However, inflammatory reactions in lung and liver cells were induced in rabbits treated at the300 µg/ kg dose level. The highest gold levels were found in the spleen, followed by liver, lungs and kidneys. These results indicated that AuNPs could be distributed extensively to various tissues in the body, but primarily in the spleen and liver. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gold%20nanoparticles" title="gold nanoparticles">gold nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=pathology" title=" pathology"> pathology</a>, <a href="https://publications.waset.org/abstracts/search?q=hematology" title=" hematology"> hematology</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20function" title=" liver function"> liver function</a>, <a href="https://publications.waset.org/abstracts/search?q=kidney%20function" title=" kidney function"> kidney function</a> </p> <a href="https://publications.waset.org/abstracts/38067/gold-nanoparticle-synthesis-characterization-clinico-pathological-pathological-and-bio-distribution-studies-in-rabbits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38067.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">335</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1058</span> Histopathological and Biochemical Evaluation of Hydroxyurea-Induced Hepato-Pulmonary Toxicity and Lymphoid Necrosis in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samah%20Oda">Samah Oda</a>, <a href="https://publications.waset.org/abstracts/search?q=Asmaa%20Khafaga"> Asmaa Khafaga</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Hashim"> Mohammed Hashim</a>, <a href="https://publications.waset.org/abstracts/search?q=Asmaa%20Khamis"> Asmaa Khamis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Toxicity of hydroxyurea (HU), a treatment for certain tumors, polycythemia, and thrombocytosis, was evaluated in rats in one-month toxicity study. Sixty male albino rats were equally classified into four groups. Rats received daily oral gavage of HU in 0, 250, 500, and 750 mg/kg b.wt. Chemical and histopathological assessment of liver, lung, spleen, and bone marrow was performed at 10, 20, and 30 days of the experiment. No significant change was reported in alanine aminotransferase (ALT), aspartate aminotransferase (AST), globulin, and albumin/ globulin ratio during the experiment. Significant decreases in alkaline phosphatase (ALP) and total albumin were reported in rats received 500 and 750 mg/kg b.wt of HU. In addition, total cholesterol level increased significantly after 10 days; however, it significantly decreased after 20 and 30 days of the experiment. Moreover, hepatocytic vacuolation and necrosis with portal inflammatory infiltrates were reported along experimental periods. Pulmonary congestion, hemorrhage, interstitial mononuclear infiltration, peribronchitis, and bronchial epithelial necrosis were also reported. Severe lymphocytic necrosis in spleen and severe loss of hematopoietic cells and replacement with corresponding adipose tissue in bone marrow tissues was demonstrated. In conclusion, HU could be able to induce severe dose and time-dependent hepato-pulmonary toxicity and lymphoid depression in rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydroxyurea" title="hydroxyurea">hydroxyurea</a>, <a href="https://publications.waset.org/abstracts/search?q=hepato-pulmonary%20toxicity" title=" hepato-pulmonary toxicity"> hepato-pulmonary toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphoid%20depression" title=" lymphoid depression"> lymphoid depression</a>, <a href="https://publications.waset.org/abstracts/search?q=histopathology" title=" histopathology"> histopathology</a> </p> <a href="https://publications.waset.org/abstracts/99571/histopathological-and-biochemical-evaluation-of-hydroxyurea-induced-hepato-pulmonary-toxicity-and-lymphoid-necrosis-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99571.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">149</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1057</span> Computer-Aided Detection of Liver and Spleen from CT Scans using Watershed Algorithm</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Belgherbi%20Aicha">Belgherbi Aicha</a>, <a href="https://publications.waset.org/abstracts/search?q=Bessaid%20Abdelhafid"> Bessaid Abdelhafid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the recent years a great deal of research work has been devoted to the development of semi-automatic and automatic techniques for the analysis of abdominal CT images. The first and fundamental step in all these studies is the semi-automatic liver and spleen segmentation that is still an open problem. In this paper, a semi-automatic liver and spleen segmentation method by the mathematical morphology based on watershed algorithm has been proposed. Our algorithm is currency in two parts. In the first, we seek to determine the region of interest by applying the morphological to extract the liver and spleen. The second step consists to improve the quality of the image gradient. In this step, we propose a method for improving the image gradient to reduce the over-segmentation problem by applying the spatial filters followed by the morphological filters. Thereafter we proceed to the segmentation of the liver, spleen. The aim of this work is to develop a method for semi-automatic segmentation liver and spleen based on watershed algorithm, improve the accuracy and the robustness of the liver and spleen segmentation and evaluate a new semi-automatic approach with the manual for liver segmentation. To validate the segmentation technique proposed, we have tested it on several images. Our segmentation approach is evaluated by comparing our results with the manual segmentation performed by an expert. The experimental results are described in the last part of this work. The system has been evaluated by computing the sensitivity and specificity between the semi-automatically segmented (liver and spleen) contour and the manually contour traced by radiological experts. Liver segmentation has achieved the sensitivity and specificity; sens Liver=96% and specif Liver=99% respectively. Spleen segmentation achieves similar, promising results sens Spleen=95% and specif Spleen=99%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CT%20images" title="CT images">CT images</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20and%20spleen%20segmentation" title=" liver and spleen segmentation"> liver and spleen segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=anisotropic%20diffusion%20filter" title=" anisotropic diffusion filter"> anisotropic diffusion filter</a>, <a href="https://publications.waset.org/abstracts/search?q=morphological%20filters" title=" morphological filters"> morphological filters</a>, <a href="https://publications.waset.org/abstracts/search?q=watershed%20algorithm" title=" watershed algorithm"> watershed algorithm</a> </p> <a href="https://publications.waset.org/abstracts/7381/computer-aided-detection-of-liver-and-spleen-from-ct-scans-using-watershed-algorithm" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7381.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">325</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1056</span> Physicochemical Properties and Toxicity Studies on a Lectin from the Bulb of Dioscorea bulbifera</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Uchenna%20Nkiruka%20Umeononihu">Uchenna Nkiruka Umeononihu</a>, <a href="https://publications.waset.org/abstracts/search?q=Adenike%20Kuku"> Adenike Kuku</a>, <a href="https://publications.waset.org/abstracts/search?q=Oludele%20Odekanyin"> Oludele Odekanyin</a>, <a href="https://publications.waset.org/abstracts/search?q=Olubunmi%20Babalola"> Olubunmi Babalola</a>, <a href="https://publications.waset.org/abstracts/search?q=Femi%20Agboola"> Femi Agboola</a>, <a href="https://publications.waset.org/abstracts/search?q=Rapheal%20Okonji"> Rapheal Okonji</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, a lectin from the bulb of Dioscorea bulbifera was purified, characterised, and its acute and sub-acute toxicity was investigated with a view to evaluate its toxic effects in mice. The protein from the bulb was extracted by homogenising 50 g of the bulb in 500 ml of phosphate buffered saline (0.025 M) of pH 7.2, stirred for 3 hr, and centrifuged at the speed of 3000 rpm. Blood group and sugar specificity assays of the crude extract were determined. The lectin was purified in a two-step procedure- gel filtration on Sephadex G-75 and affinity chromatography on Sepharose 4-B arabinose. The degree of purity of the purified lectin was ascertained by SDS-polyacrylamide gel electrophoresis. Detection of covalently bound carbohydrate was carried out with Periodic Acid-Schiffs (PAS) reagent staining technique. Effects of temperature, pH, and EDTA on the lectin were carried out using standard methods. This was followed by acute toxicity studies via oral and subcutaneous routes using mice. The animals were monitored for mortality and signs of toxicity. The sub-acute toxicity studies were carried out using rats. Different concentrations of the lectin were administered twice daily for 5 days via the subcutaneous route. The animals were sacrificed on the sixth day; blood samples and liver tissues were collected. Biochemical assays (determination of total protein, direct bilirubin, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), catalase (CAT), and superoxide dismutase (SOD)) were carried out on the serum and liver homogenates. The collected organs (heart, liver, kidney, and spleen) were subjected to histopathological analysis. The results showed that lectin from the bulbs of Dioscorea bulbifera agglutinated non-specifically the erythrocytes of the human ABO system as well as rabbit erythrocytes. The haemagglutinating activity was strongly inhibited by arabinose and dulcitol with minimum inhibitory concentrations of 0.781 and 6.25, respectively. The lectin was purified to homogeneity with native and subunit molecular weights of 56,273 and 29,373 Daltons, respectively. The lectin was thermostable up to 30 0C and lost 25 %, 33.3 %, and 100 % of its heamagglutinating activity at 40°C, 50°C, and 60°C, respectively. The lectin was maximally active at pH 4 and 5 but lost its total activity at pH eight, while EDTA (10 mM) had no effect on its haemagglutinating activity. PAS reagent staining showed that the lectin was not a glycoprotein. The sub-acute studies on rats showed elevated levels of ALT, AST, serum bilirubin, total protein in serum and liver homogenates suggesting damage to liver and spleen. The study concluded that the aerial bulb of D. bulbifera lectin was non-specific in its heamagglutinating activity and dimeric in its structure. The lectin shared some physicochemical characteristics with lectins from other Dioscorecea species and was moderately toxic to the liver and spleen of treated animals. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dioscorea%20bulbifera" title="Dioscorea bulbifera">Dioscorea bulbifera</a>, <a href="https://publications.waset.org/abstracts/search?q=heamagglutinin" title=" heamagglutinin"> heamagglutinin</a>, <a href="https://publications.waset.org/abstracts/search?q=lectin" title=" lectin"> lectin</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a> </p> <a href="https://publications.waset.org/abstracts/130539/physicochemical-properties-and-toxicity-studies-on-a-lectin-from-the-bulb-of-dioscorea-bulbifera" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/130539.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">127</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1055</span> Green Synthesis of Silver Nanoparticles, Their Toxicity and Biomedical Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kiran%20Shehzadi">Kiran Shehzadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasmeen%20Akhtar"> Yasmeen Akhtar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mujahid%20Ameen"> Mujahid Ameen</a>, <a href="https://publications.waset.org/abstracts/search?q=Tabinda%20Ijaz"> Tabinda Ijaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Shoukat%20Siddique"> Shoukat Siddique</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles, due to their different sizes and morphologies, are employed in various fields such as the medical field, cosmetics, pharmaceutical, textile industry as well as in paints, adhesives, and electronics. Metal nanoparticles exhibit excellent antimicrobial activity, dye degradation and can be used as anti-cancerous drug loading agents. In this study, sZilver nanoparticles (Ag-NPs) were synthesized employing doxycycline (antibiotic) as a reducing and capping agent (biological/green synthesis). Produced Ag-NPS were characterized using UV/VIS spectrophotometry, XRD, SEM, and FTIR. Surface plasmon resonance (SPR) of silver nanoparticles was observed at 411nm with 90nm size with homogenized spherical shape. These particles revealed good inhibition zones for Fungi such as Candida albicans and Candida tropicalis. In this study, toxic properties of Ag-NPs were monitored by allowing them to penetrate in the cell, causing an abrupt increase in oxidative stress, which resulted ultimately in cell death. Histopathological analysis of mice organs was performed by administering definite concentrations of silver nanoparticles orally to mice for 14 days. Toxic properties were determined, and it was revealed that the toxicity of silver nanoparticles mainly depends on the size. Silver nanoparticles of this work presented mild toxicity for different organs (liver, kidney, spleen, heart, and stomach) of mice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=metal%20nanoparticles" title="metal nanoparticles">metal nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=green%2Fbiological%20methods" title=" green/biological methods"> green/biological methods</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=Candida%20albicans" title=" Candida albicans"> Candida albicans</a>, <a href="https://publications.waset.org/abstracts/search?q=Candida%20tropicalis" title=" Candida tropicalis"> Candida tropicalis</a> </p> <a href="https://publications.waset.org/abstracts/135401/green-synthesis-of-silver-nanoparticles-their-toxicity-and-biomedical-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135401.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1054</span> Segmentation of the Liver and Spleen From Abdominal CT Images Using Watershed Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Belgherbi%20Aicha">Belgherbi Aicha</a>, <a href="https://publications.waset.org/abstracts/search?q=Hadjidj%20Ismahen"> Hadjidj Ismahen</a>, <a href="https://publications.waset.org/abstracts/search?q=Bessaid%20Abdelhafid"> Bessaid Abdelhafid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The phase of segmentation is an important step in the processing and interpretation of medical images. In this paper, we focus on the segmentation of liver and spleen from the abdomen computed tomography (CT) images. The importance of our study comes from the fact that the segmentation of ROI from CT images is usually a difficult task. This difficulty is the gray’s level of which is similar to the other organ also the ROI are connected to the ribs, heart, kidneys, etc. Our proposed method is based on the anatomical information and mathematical morphology tools used in the image processing field. At first, we try to remove the surrounding and connected organs and tissues by applying morphological filters. This first step makes the extraction of interest regions easier. The second step consists of improving the quality of the image gradient. In this step, we propose a method for improving the image gradient to reduce these deficiencies by applying the spatial filters followed by the morphological filters. Thereafter we proceed to the segmentation of the liver, spleen. To validate the segmentation technique proposed, we have tested it on several images. Our segmentation approach is evaluated by comparing our results with the manual segmentation performed by an expert. The experimental results are described in the last part of this work.The system has been evaluated by computing the sensitivity and specificity between the semi-automatically segmented (liver and spleen) contour and the manually contour traced by radiological experts. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CT%20images" title="CT images">CT images</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20and%20spleen%20segmentation" title=" liver and spleen segmentation"> liver and spleen segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=anisotropic%20diffusion%20filter" title=" anisotropic diffusion filter"> anisotropic diffusion filter</a>, <a href="https://publications.waset.org/abstracts/search?q=morphological%20filters" title=" morphological filters"> morphological filters</a>, <a href="https://publications.waset.org/abstracts/search?q=watershed%20algorithm" title=" watershed algorithm"> watershed algorithm</a> </p> <a href="https://publications.waset.org/abstracts/19950/segmentation-of-the-liver-and-spleen-from-abdominal-ct-images-using-watershed-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19950.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">495</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1053</span> Gamma-Hydroxybutyrate (GHB): A Review for the Prehospital Clinician</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Theo%20Welch">Theo Welch</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Gamma-hydroxybutyrate (GHB) is a depressant of the central nervous system with euphoric effects. It is being increasingly used recreationally in the United Kingdom (UK) despite associated morbidity and mortality. Due to the lack of evidence, healthcare professionals remain unsure as to the optimum management of GHB acute toxicity. Methods: A literature review was undertaken of its pharmacology and the emergency management of its acute toxicity.Findings: GHB is inexpensive and readily available over the Internet. Treatment of GHB acute toxicity is supportive. Clinicians should pay particular attention to the airway as emesis is common. Intubation is required in a minority of cases. Polydrug use is common and worsens prognosis. Conclusion: An inexpensive and readily available drug, GHB acute toxicity can be difficult to identify and treat. GHB acute toxicity is generally treated conservatively. Further research is needed to ascertain the indications, benefits, and risks of intubating patients with GHB acute toxicity. instructions give you guidelines for preparing papers for the conference. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=GHB" title="GHB">GHB</a>, <a href="https://publications.waset.org/abstracts/search?q=gamma-hydroxybutyrate" title=" gamma-hydroxybutyrate"> gamma-hydroxybutyrate</a>, <a href="https://publications.waset.org/abstracts/search?q=prehospital" title=" prehospital"> prehospital</a>, <a href="https://publications.waset.org/abstracts/search?q=emergency" title=" emergency"> emergency</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=management" title=" management"> management</a> </p> <a href="https://publications.waset.org/abstracts/141712/gamma-hydroxybutyrate-ghb-a-review-for-the-prehospital-clinician" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141712.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1052</span> Rice Bran Material Enrichment of Granulated Cane Brown Sugar to Increase Policosanol Contents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Monthana%20Weerawatanakorn">Monthana Weerawatanakorn</a>, <a href="https://publications.waset.org/abstracts/search?q=Hajime%20Tamaki"> Hajime Tamaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Yonathan%20Asikin"> Yonathan Asikin</a>, <a href="https://publications.waset.org/abstracts/search?q=Koji%20Wada"> Koji Wada</a>, <a href="https://publications.waset.org/abstracts/search?q=Makoto%20Takahashi"> Makoto Takahashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi-Tang%20Ho"> Chi-Tang Ho</a>, <a href="https://publications.waset.org/abstracts/search?q=Min-Hsiung%20Pan"> Min-Hsiung Pan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Rice bran and sugarcane are significant sources of wax containing policosanol (PC), the cholesterol-lowering nutraceutical available in the market. The processing of rice bran oil causes the loss of PC content into various waste products. Therefore, we hypothesise that defatted rice bran (DRB) as agricultural waste product and rice bran oil (RBO) retain a varying but significant amount of PC wax. Non-centrifugal cane sugar (NCS) or cane brown sugar has been consumed worldwide and possesses various health benefits. Since PC wax is mainly in the outer layer rinds of cane, PC contents of the granulated sugar are reduced due to the peeling step. The study aimed to increase PC contents of the granular brown sugar by adding wax extracted from DRB and RBO and to investigate the toxicity of the developed products. The results showed that the total PC contents including long chain aldehyde of products were increased to the maximum level of 147.97 mg/100 g and 40.14 mg/100 g for extracted wax and rice bran oil addition, respectively. PC content of RBO was found to be 96.93 mg/100 g. DRB is promising source of policosanol (6,044.7 mg/100 g). The 28-day toxicity evaluations of the developed sugar revealed no adverse effects on the liver, spleen or kidney. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=enrichment" title="enrichment">enrichment</a>, <a href="https://publications.waset.org/abstracts/search?q=sugarcane" title=" sugarcane"> sugarcane</a>, <a href="https://publications.waset.org/abstracts/search?q=policosanol" title=" policosanol"> policosanol</a>, <a href="https://publications.waset.org/abstracts/search?q=defatted%20rice%20bran" title=" defatted rice bran"> defatted rice bran</a>, <a href="https://publications.waset.org/abstracts/search?q=wax" title=" wax"> wax</a> </p> <a href="https://publications.waset.org/abstracts/54229/rice-bran-material-enrichment-of-granulated-cane-brown-sugar-to-increase-policosanol-contents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54229.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">371</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1051</span> Anatomical Studies on the Spleen and Mesenteric Lymph Node of the Grasscutter</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20M.%20Korzerzer">R. M. Korzerzer</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20O.%20Hambolu"> J. O. Hambolu</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20O.%20Salami"> S. O. Salami</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20B.%20Oladele"> S. B. Oladele</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The grasscutter (Thryonomys swinderianus) has become an important source of protein and income to rural dwellers in most West African countries including Nigeria. Twelve apparently healthy grasscutters consisting of six males and six females between the ages of three and seven months were obtained from rural dwellers in Benue state and used for this study. The animals were transported by means of constructed cages to the Department of Veterinary Anatomy, Ahmadu Bello University, Zaria and sacrificed using chloroform inhalation gaseous anaesthesia by suffocation. The spleen and mesenteric lymph nodes were extirpated and the tissues prepared using standard methods, haematoxilin and eosin stain was used for routine histology, while Rhodamine B-aniline-methylene blue stain was used for staining reticular and elastic fibres. The spleen was dark red in colour and roughly triangular in outline, and was observed to increase consistently with age, maximum values were recorded at seven months of age in both males and females. Mean ± SEM values for splenic weights were 0.67 ± 0.09 g, 1.65 ± 0.35 g and 2.31 ± 0.06 g at three, five and seven months of age, respectively. The percentage ratio of splenic weight to body weight was 0.1%. Histologically, the germinal centres revealed three zones; the germinal centre, cortical layer and the marginal zone. The mesenteric lymph nodes were constantly bean shaped and appeared as opaque white masses which resemble fat but were distinguished from fat by their pearly glossy nature. The mean ± SEM values for mesenteric lymph node weights were 0.056 ± 0.005 g, 0.143 ± 0.034 g and 0.1600 ± 0.023 g at three, five and seven months of age, respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anatomical" title="anatomical">anatomical</a>, <a href="https://publications.waset.org/abstracts/search?q=spleen" title=" spleen"> spleen</a>, <a href="https://publications.waset.org/abstracts/search?q=mesenteric%20lymph%20node" title=" mesenteric lymph node"> mesenteric lymph node</a>, <a href="https://publications.waset.org/abstracts/search?q=grasscutter" title=" grasscutter"> grasscutter</a> </p> <a href="https://publications.waset.org/abstracts/8454/anatomical-studies-on-the-spleen-and-mesenteric-lymph-node-of-the-grasscutter" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8454.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">587</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1050</span> Prevalence and Risk Factors of Economic Toxicity in Gynecologic Malignancies: A Systematic Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dongliu%20Li">Dongliu Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: This study systematically evaluates the incidence and influencing factors of economic toxicity in patients with gynecological malignant tumors. Methods: Literature on economic toxicity of gynecological malignancies were comprehensively searched in Pubmed, The Cochrane Library, Web of Science, Embase, CINAHL, CNKI, Wanfang Database, Chinese Biomedical Literature database and VIP database. The search period is up to February 2024. Stata 17 software was used to conduct a single-group meta-analysis of the incidence of economic toxicity in gynecological malignant tumors, and descriptive analysis was used to analyze the influencing factors. Results: A total of 11 pieces of literature were included, including 6475 patients with gynecological malignant tumors. The results of the meta-analysis showed that the incidence of economic toxicity in gynecological malignant tumors was 40% (95%CI 31%—48%). The influencing factors of economic toxicity in patients with gynecological malignant tumors include social demographic factors, medical insurance-related factors and disease-related factors. Conclusion: The incidence of economic toxicity in patients with gynecological malignant tumors is high, and medical staff should conduct early screening of patients according to relevant influencing factors, personalized assessment of patients' economic status, early prevention work and personalized intervention measures. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gynecological%20malignancy" title="gynecological malignancy">gynecological malignancy</a>, <a href="https://publications.waset.org/abstracts/search?q=economic%20toxicity" title=" economic toxicity"> economic toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20incidence%20rate" title=" the incidence rate"> the incidence rate</a>, <a href="https://publications.waset.org/abstracts/search?q=influencing%20factors" title=" influencing factors"> influencing factors</a>, <a href="https://publications.waset.org/abstracts/search?q=systematic%20review" title=" systematic review"> systematic review</a> </p> <a href="https://publications.waset.org/abstracts/191619/prevalence-and-risk-factors-of-economic-toxicity-in-gynecologic-malignancies-a-systematic-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/191619.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">30</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1049</span> Isolated Hydatidosis of Spleen: A Rare Entity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anshul%20Raja">Anshul Raja</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cystic lesions of the spleen are rare and splenic hydatid cysts account for only 0.5% to 8% of all hydatidosis. Authors hereby report a case where a 50-year-old female presented to our hospital with the complains of heaviness and pain over left upper abdomen over the past 8-10 years. On radiological examination, ultrasonography revealed findings consistent with isolated splenic hydatid cyst and was later on confirmed on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). No other organ or system involvement was seen. The patient underwent splenectomy and hydatid cyst was confirmed on histopathology. Owing to its rarity, it offers a diagnostic challenge to physicians but can reliably be diagnosed with great confidence employing various imaging modalities like CT and MRI. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gastrointestinal%20radiology" title="gastrointestinal radiology">gastrointestinal radiology</a>, <a href="https://publications.waset.org/abstracts/search?q=abdominal%20imaging" title=" abdominal imaging"> abdominal imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=hydatid%20cyst" title=" hydatid cyst"> hydatid cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20and%20health%20sciences" title=" medical and health sciences"> medical and health sciences</a> </p> <a href="https://publications.waset.org/abstracts/18260/isolated-hydatidosis-of-spleen-a-rare-entity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">405</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1048</span> Abdominal Organ Segmentation in CT Images Based On Watershed Transform and Mosaic Image</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Belgherbi%20Aicha">Belgherbi Aicha</a>, <a href="https://publications.waset.org/abstracts/search?q=Hadjidj%20Ismahen"> Hadjidj Ismahen</a>, <a href="https://publications.waset.org/abstracts/search?q=Bessaid%20Abdelhafid"> Bessaid Abdelhafid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Accurate Liver, spleen and kidneys segmentation in abdominal CT images is one of the most important steps for computer aided abdominal organs pathology diagnosis. In this paper, we have proposed a new semi-automatic algorithm for Liver, spleen and kidneys area extraction in abdominal CT images. Our proposed method is based on hierarchical segmentation and watershed algorithm. In our approach, a powerful technique has been designed to suppress over-segmentation based on mosaic image and on the computation of the watershed transform. The algorithm is currency in two parts. In the first, we seek to improve the quality of the gradient-mosaic image. In this step, we propose a method for improving the gradient-mosaic image by applying the anisotropic diffusion filter followed by the morphological filters. Thereafter we proceed to the hierarchical segmentation of the liver, spleen and kidney. To validate the segmentation technique proposed, we have tested it on several images. Our segmentation approach is evaluated by comparing our results with the manual segmentation performed by an expert. The experimental results are described in the last part of this work. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anisotropic%20diffusion%20filter" title="anisotropic diffusion filter">anisotropic diffusion filter</a>, <a href="https://publications.waset.org/abstracts/search?q=CT%20images" title=" CT images"> CT images</a>, <a href="https://publications.waset.org/abstracts/search?q=morphological%20filter" title=" morphological filter"> morphological filter</a>, <a href="https://publications.waset.org/abstracts/search?q=mosaic%20image" title=" mosaic image"> mosaic image</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-abdominal%20organ%20segmentation" title=" multi-abdominal organ segmentation"> multi-abdominal organ segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=mosaic%20image" title=" mosaic image"> mosaic image</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20watershed%20algorithm" title=" the watershed algorithm"> the watershed algorithm</a> </p> <a href="https://publications.waset.org/abstracts/20011/abdominal-organ-segmentation-in-ct-images-based-on-watershed-transform-and-mosaic-image" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20011.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">499</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1047</span> Estimation of the Acute Toxicity of Halogenated Phenols Using Quantum Chemistry Descriptors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khadidja%20Bellifa">Khadidja Bellifa</a>, <a href="https://publications.waset.org/abstracts/search?q=Sidi%20Mohamed%20Mekelleche"> Sidi Mohamed Mekelleche</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phenols and especially halogenated phenols represent a substantial part of the chemicals produced worldwide and are known as aquatic pollutants. Quantitative structure–toxicity relationship (QSTR) models are useful for understanding how chemical structure relates to the toxicity of chemicals. In the present study, the acute toxicities of 45 halogenated phenols to Tetrahymena Pyriformis are estimated using no cost semi-empirical quantum chemistry methods. QSTR models were established using the multiple linear regression technique and the predictive ability of the models was evaluated by the internal cross-validation, the Y-randomization and the external validation. Their structural chemical domain has been defined by the leverage approach. The results show that the best model is obtained with the AM1 method (R²= 0.91, R²CV= 0.90, SD= 0.20 for the training set and R²= 0.96, SD= 0.11 for the test set). Moreover, all the Tropsha’ criteria for a predictive QSTR model are verified. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=halogenated%20phenols" title="halogenated phenols">halogenated phenols</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity%20mechanism" title=" toxicity mechanism"> toxicity mechanism</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobicity" title=" hydrophobicity"> hydrophobicity</a>, <a href="https://publications.waset.org/abstracts/search?q=electrophilicity%20index" title=" electrophilicity index"> electrophilicity index</a>, <a href="https://publications.waset.org/abstracts/search?q=quantitative%20stucture-toxicity%20relationships" title=" quantitative stucture-toxicity relationships"> quantitative stucture-toxicity relationships</a> </p> <a href="https://publications.waset.org/abstracts/45757/estimation-of-the-acute-toxicity-of-halogenated-phenols-using-quantum-chemistry-descriptors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45757.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">300</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1046</span> Do Immune Organ Weights Indicate Immunomodulation of Polyunsaturated Fatty Acids?</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Al-Khalifa">H. Al-Khalifa</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Al-Nasser"> A. Al-Nasser</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main immune organs in poultry are the thymus, spleen and bursa of Fabricius. During an immune response, mature lymphocytes and other immune cells interact with antigens in these tissues. Consequently, the mass of these organs can in some cases indicate immune status. The objective of the current study was to investigate the effect of feeding flaxseed on immune tissue weights. Cobb 500 broiler chickens were fed flaxseed at 15%, the control diet did not contain any flaxseed. Results showed that dietary supplementation with flaxseed did not affect the weights of the spleens of broiler chickens. However, it significantly lowered bursa weights (p<0.01), compared to the control diet. In addition, the bursae were thinner in appearance compared with bursii from chickens fed the control diets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bursa%20of%20fabricius" title="bursa of fabricius">bursa of fabricius</a>, <a href="https://publications.waset.org/abstracts/search?q=flaxseed" title=" flaxseed"> flaxseed</a>, <a href="https://publications.waset.org/abstracts/search?q=spleen" title=" spleen"> spleen</a>, <a href="https://publications.waset.org/abstracts/search?q=thymus" title=" thymus"> thymus</a> </p> <a href="https://publications.waset.org/abstracts/28247/do-immune-organ-weights-indicate-immunomodulation-of-polyunsaturated-fatty-acids" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28247.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">444</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1045</span> Metal Nanoparticles Caused Death of Metastatic MDA-MB-231 Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=O.%20S.%20Adeyemi">O. S. Adeyemi</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20G.%20Whiteley"> C. G. Whiteley</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study determined the toxic potential of metal nanoparticles in cell culture system. Silver and gold nanoparticles were synthesized and characterized following established "green" protocols. The synthesized nanoparticles, in varying concentrations ranging from 0.1–100 µM were evaluated for toxicity in metastatic MDA-MB-231 cells. The nanoparticles promoted a generation of reactive oxygen species and reduced cell viability to less than 50% in the demonstration of cellular toxicity. The nanoparticles; gold and the silver-gold mixture had IC50 values of 56.65 and 18.44 µM respectively. The IC50 concentration for silver nanoparticles could not be determined. Furthermore, the probe of the cell death using flow cytometry and confocal microscopy revealed the partial involvement of apoptosis as well as necrosis. Our results revealed cellular toxicity caused by the nanoparticles but the mechanism remains yet undefined. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cell%20death" title="cell death">cell death</a>, <a href="https://publications.waset.org/abstracts/search?q=nanomedicine" title=" nanomedicine"> nanomedicine</a>, <a href="https://publications.waset.org/abstracts/search?q=nanotoxicology" title=" nanotoxicology"> nanotoxicology</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity "> toxicity </a> </p> <a href="https://publications.waset.org/abstracts/24934/metal-nanoparticles-caused-death-of-metastatic-mda-mb-231-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24934.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">394</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1044</span> Transcriptome Sequencing of the Spleens Reveals Genes Involved in Antiviral Response in Chickens Infected with Castv</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sajewicz-Krukowska%20Joanna">Sajewicz-Krukowska Joanna</a>, <a href="https://publications.waset.org/abstracts/search?q=Doma%C5%84ska-Blicharz%20Katarzyna"> Domańska-Blicharz Katarzyna</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarasiuk%20Karolina"> Tarasiuk Karolina</a>, <a href="https://publications.waset.org/abstracts/search?q=Marzec-Kotarska%20Barbara"> Marzec-Kotarska Barbara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Astroviral infections pose a significant problem in the poultry industry, leading to multiple adverse effects such as decreased egg production, breeding disorders, poor weight gain, and even increased mortality. Commonly observed chicken astrovirus (CAstV) was recently reported to be responsible for "white chicks syndrome" associated with increased embryo/chick mortality. The CAstV-mediated pathogenesis in chicken occurs due to complex interactions between the infectious pathogen and the immune system. Many aspects of CAstV-chicken interactions remain unclear, and there is no information available regarding gene expression changes in the chicken's spleen in response to CAstV infection. We aimed to investigate the molecular background triggered by CAstV infection. Ten 21-day-old SPF White Leghorn chickens were divided into two groups of 5 birds each. One group was inoculated with CAstV, and the other was used as the negative control. On 4th dpi, spleen samples were collected and immediately frozen at -70°C for RNA isolation. We analysed transcriptional profiles of the chickens' spleens at the 4th day following infection using RNA-seq to establish differentially expressed genes (DEGs). The RNA-seq findings were verified by quantitative real-time PCR (qRT-PCR). A total of 31959 transcripts were identified in response to CAstV infection. Eventually 45 DEGs (p-value<0.05; Log2Foldchange>1)were recognized in the spleen after CAstV infection (26 upregulated DEGs and 19 downregulated DEGs). qRT-PCR performed on 4 genes (IFIT5, OASL, RASD1, DDX60) confirmed RNAseq results. Top differentially expressed genes belonged to novel putative IFN-induced CAstV restriction factors. Most of the DEGs were associated with RIG-I–like signalling pathway or, more generally, with an innate antiviral response(upregulated: BLEC3, CMPK2, IFIT5, OASL, DDX60, IFI6, and downregulated: SPIK5, SELENOP, HSPA2, TMEM158, RASD1, YWHAB). The study provided a global analysis of host transcriptional changes that occur during CAstV infection in vivo and proved the cell cycle in the spleen and immune signalling in chickens were predominantly affected upon CAstV infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chicken%20astrovirus" title="chicken astrovirus">chicken astrovirus</a>, <a href="https://publications.waset.org/abstracts/search?q=CastV" title=" CastV"> CastV</a>, <a href="https://publications.waset.org/abstracts/search?q=RNA-seq" title=" RNA-seq"> RNA-seq</a>, <a href="https://publications.waset.org/abstracts/search?q=transcriptome" title=" transcriptome"> transcriptome</a>, <a href="https://publications.waset.org/abstracts/search?q=spleen" title=" spleen"> spleen</a> </p> <a href="https://publications.waset.org/abstracts/141921/transcriptome-sequencing-of-the-spleens-reveals-genes-involved-in-antiviral-response-in-chickens-infected-with-castv" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141921.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">154</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1043</span> Toxicological Study of Umbilicus rupesris L. Leaves: Hematological, Biochemical, and Histopathological Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Afaf%20Benhouda">Afaf Benhouda</a>, <a href="https://publications.waset.org/abstracts/search?q=Mouloud%20Yahia"> Mouloud Yahia</a>, <a href="https://publications.waset.org/abstracts/search?q=Hachani%20Khadraoui"> Hachani Khadraoui</a>, <a href="https://publications.waset.org/abstracts/search?q=Asma%20Meddour"> Asma Meddour</a>, <a href="https://publications.waset.org/abstracts/search?q=Souhila%20Benbia"> Souhila Benbia</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdelmoudjib%20Ghecham"> Abdelmoudjib Ghecham</a>, <a href="https://publications.waset.org/abstracts/search?q=Djahida%20Benhouda"> Djahida Benhouda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Umbilicus rupestris (UR) is an herbal medicine traditionally applied against the ignitions of the skin. The present paper aimed to study the acute and subacute toxicity with orally administered methanolic leaves extract of Umbilicus rupestris L (URMeOH). In acute toxicity tests, four groups of rats (n = 6/group/female) were orally treated with doses of 500, 1000, 1500 and 2000 mg/kg, and general behaviour, adverse effects, and mortality were recorded for up to 14 days. In subacute toxicity study, rats received URAMeOH by gavage at the doses of 100, 200 mg/kg/day (n = 6/group) for 28 days, and biochemical, hematological, and histopathological changes in tissues (liver, kidney) were determined. URMeOH did not produce any hazardous symptoms or death and in the acute toxicity test. Subacute treatment with URMeOH did not show any change in body weight, and hematological and biochemical profiles. In addition, no change was observed either in macroscopic or microscopic aspects of vital organs in rats. Our result showed that Umbilicus rupestris extract could be safe for human use. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title="acute toxicity">acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=biochemical%20parameters" title=" biochemical parameters"> biochemical parameters</a>, <a href="https://publications.waset.org/abstracts/search?q=hematological%20parameters" title=" hematological parameters"> hematological parameters</a>, <a href="https://publications.waset.org/abstracts/search?q=Umbilicus%20rupestris" title=" Umbilicus rupestris"> Umbilicus rupestris</a>, <a href="https://publications.waset.org/abstracts/search?q=subacute%20toxicity" title=" subacute toxicity"> subacute toxicity</a> </p> <a href="https://publications.waset.org/abstracts/6931/toxicological-study-of-umbilicus-rupesris-l-leaves-hematological-biochemical-and-histopathological-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6931.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">345</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1042</span> Antioxidant and Acute Toxicity of Stem Extracts of the Ficus Iteophylla</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Mukhtar">Muhammad Mukhtar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study is to evaluate the antioxidant activity and acute toxicity of the extracts of Ficus iteophylla by reactions with 1, 1-diphenyl-2-picryhydrazyl radical (DPPH) and method developed by Lork 1983, respectively. Stem bark of Ficus iteophylla was collected, air dried, pulverized to fine powdered and sequentially extracted using acetone, methanol and water in order of increasing polarity. The result shows strong radical scavenging activity against DPPH for all the extracts when compared with ascorbic acid. The LD50 of 316 mg/kg was calculated for all the three extras, and the values were found to be within the practically toxic range, and therefore, care should be taken when using the plants in traditional medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title="antioxidant">antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title=" acute toxicity"> acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=Ficus%20iteophylla" title=" Ficus iteophylla"> Ficus iteophylla</a> </p> <a href="https://publications.waset.org/abstracts/125341/antioxidant-and-acute-toxicity-of-stem-extracts-of-the-ficus-iteophylla" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/125341.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1041</span> Acute Oral Toxicity Study of Mystroxylon aethiopicum Root Bark Aqueous Extract in Albino Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mhuji%20Kilonzo">Mhuji Kilonzo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Acute oral toxicity of Mystroxylon aethiopicum root bark aqueous was evaluated in albino mice of either sex. In this study, five groups of mice were orally treated with doses of 1000, 2000, 3000, 4000 and 5000 mg/kg body weight of the crude extract. The mortality, signs of toxicity and body weights were observed individually for two weeks. At the end of the two weeks study, all animals were sacrificed, and the hematological and biochemical parameters, as well as organ weights relative to body weight of each animal, were determined. No mortality, signs of toxicity and abnormalities in vital organs were observed in the entire period of study for both treated and control groups of mice. Additionally, there were no significant changes (p > 0.05) in the blood hematology and biochemical analysis. However, the body weights of all mice increased significantly. The Mystroxylon aethiopicum root bark aqueous extract were found to have a high safe margin when administered orally. Hence, the extract can be utilized for pharmaceutical formulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20oral%20toxicity" title="acute oral toxicity">acute oral toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=albino%20mice" title=" albino mice"> albino mice</a>, <a href="https://publications.waset.org/abstracts/search?q=Mystroxylon%20aethiopicum" title=" Mystroxylon aethiopicum"> Mystroxylon aethiopicum</a>, <a href="https://publications.waset.org/abstracts/search?q=safety" title=" safety"> safety</a> </p> <a href="https://publications.waset.org/abstracts/63956/acute-oral-toxicity-study-of-mystroxylon-aethiopicum-root-bark-aqueous-extract-in-albino-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63956.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">289</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1040</span> Study of the Possibility of Adsorption of Heavy Metal Ions on the Surface of Engineered Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Antonina%20A.%20Shumakova">Antonina A. Shumakova</a>, <a href="https://publications.waset.org/abstracts/search?q=Sergey%20A.%20Khotimchenko"> Sergey A. Khotimchenko </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The relevance of research is associated, on the one hand, with an ever-increasing volume of production and the expansion of the scope of application of engineered nanomaterials (ENMs), and on the other hand, with the lack of sufficient scientific information on the nature of the interactions of nanoparticles (NPs) with components of biogenic and abiogenic origin. In particular, studying the effect of ENMs (TiO2 NPs, SiO2 NPs, Al2O3 NPs, fullerenol) on the toxicometric characteristics of common contaminants such as lead and cadmium is an important hygienic task, given the high probability of their joint presence in food products. Data were obtained characterizing a multidirectional change in the toxicity of model toxicants when they are co-administered with various types of ENMs. One explanation for this fact is the difference in the adsorption capacity of ENMs, which was further studied in in vitro studies. For this, a method was proposed based on in vitro modeling of conditions simulating the environment of the small intestine. It should be noted that the obtained data are in good agreement with the results of in vivo experiments: - with the combined administration of lead and TiO2 NPs, there were no significant changes in the accumulation of lead in rat liver; in other organs (kidneys, spleen, testes and brain), the lead content was lower than in animals of the control group; - studying the combined effect of lead and Al2O3 NPs, a multiple and significant increase in the accumulation of lead in rat liver was observed with an increase in the dose of Al2O3 NPs. For other organs, the introduction of various doses of Al2O3 NPs did not significantly affect the bioaccumulation of lead; - with the combined administration of lead and SiO2 NPs in different doses, there was no increase in lead accumulation in all studied organs. Based on the data obtained, it can be assumed that at least three scenarios of the combined effects of ENMs and chemical contaminants on the body: - ENMs quite firmly bind contaminants in the gastrointestinal tract and such a complex becomes inaccessible (or inaccessible) for absorption; in this case, it can be expected that the toxicity of both ENMs and contaminants will decrease; - the complex formed in the gastrointestinal tract has partial solubility and can penetrate biological membranes and / or physiological barriers of the body; in this case, ENMs can play the role of a kind of conductor for contaminants and, thus, their penetration into the internal environment of the body increases, thereby increasing the toxicity of contaminants; - ENMs and contaminants do not interact with each other in any way, therefore the toxicity of each of them is determined only by its quantity and does not depend on the quantity of another component. Authors hypothesized that the degree of adsorption of various elements on the surface of ENMs may be a unique characteristic of their action, allowing a more accurate understanding of the processes occurring in a living organism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=absorption" title="absorption">absorption</a>, <a href="https://publications.waset.org/abstracts/search?q=cadmium" title=" cadmium"> cadmium</a>, <a href="https://publications.waset.org/abstracts/search?q=engineered%20nanomaterials" title=" engineered nanomaterials"> engineered nanomaterials</a>, <a href="https://publications.waset.org/abstracts/search?q=lead" title=" lead"> lead</a> </p> <a href="https://publications.waset.org/abstracts/118614/study-of-the-possibility-of-adsorption-of-heavy-metal-ions-on-the-surface-of-engineered-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/118614.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">87</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1039</span> Determination of Acid Volatile Sulfides–Simultaneously Extracted Metal Relationship and Toxicity in Contaminated Sediment Layer in Mid-Black Sea Coasts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arife%20Simsek">Arife Simsek</a>, <a href="https://publications.waset.org/abstracts/search?q=Gulfem%20Bakan"> Gulfem Bakan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sediment refers to the accumulation of varying amounts of sediment material in natural waters and the formation of bottom sludge. Sediments are the most important sources of pollutants as well as important future sources and carriers of pollutants. The accumulation of pollutants in sediments can cause serious environmental problems for the surrounding areas. Heavy metals (such as Cr, Cd, Al, Pb, Cu, Al, Zn) disrupt the water quality, affect the useful use of sediment, affect the ecosystem and have a toxic effect on the life of the sediment layer. This effect, which accumulates in the aquatic organisms, can enter the human body with the food chain and affect health seriously. Potential metal toxicity can be determined by comparing acid volatile sulfides (AVS) – simultaneously extracted metal (SEM) ratio in anoxic sediments to determine the effect of metals. Determination of the concentration of SEM and AVS is useful in screening sediments for potential toxicity due to the high metal concentration. In the case of SEM/AVS < 0 (anoxic sediment); in terms of AVS biomass production, its toxicity can be controlled. No toxic effects may be observed when SEM / AVS < 0. SEM / AVS > 0 (in the case of oxic sediment); metals with sensitive fraction such as Cu, As, Ag, Zn are stored. In this study, AVS and SEM measurements of sediment samples collected from five different points in the district of Tekkeköy in Samsun province were performed. The SEM - AVS ratio was greater than 0 in all samples. Therefore, it is necessary to test the toxicity against the risks that may occur in the ecosystem. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=AVS-SEM" title="AVS-SEM">AVS-SEM</a>, <a href="https://publications.waset.org/abstracts/search?q=Black%20Sea" title=" Black Sea"> Black Sea</a>, <a href="https://publications.waset.org/abstracts/search?q=heavy%20metal" title=" heavy metal"> heavy metal</a>, <a href="https://publications.waset.org/abstracts/search?q=sediment" title=" sediment"> sediment</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a> </p> <a href="https://publications.waset.org/abstracts/107175/determination-of-acid-volatile-sulfides-simultaneously-extracted-metal-relationship-and-toxicity-in-contaminated-sediment-layer-in-mid-black-sea-coasts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/107175.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">138</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1038</span> DNA Methylation 6mA and Histone Methylation Involved in Multi-/Trans-Generational Reproductive Effects in Caenorhabditis elegans Induced by Atrazine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jiechen%20Yin">Jiechen Yin</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiang%20Hong"> Xiang Hong</a>, <a href="https://publications.waset.org/abstracts/search?q=Ran%20Liu"> Ran Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Atrazine (ATR), a widely used triazine herbicide, is an environmental endocrine disruptor that can cause health problems. However, whether there are multi/trans-generational reproductive impacts of ATR have not been studied to our best knowledge. Therefore, in this study, Caenorhabditis elegans was used as a preferable model organism to identify the multi/trans-generational reproductive toxicity of ATR. L1 larvae were exposed to different concentrations (0.0004–40 mg/L) of ATR for 48 h. Successive generations (F1 to F5) were fed without ATR and consecutive exposure. The results showed that ATR exposure during P0 decreased fecundity, including a reduction in fertilized eggs, oocytes, and ovulation rate, delayed gonadal development, and decreased the relative area of the gonad arm and germ cell number. Furthermore, continuous ATR exposure (P0–F5) causes a significant increase in reproductive toxicity in subsequent generations, although no significant toxicity occurred in the P0 generation after exposure to environmental-related concentrations, suggesting that ATR exposure might have cumulative effects. Likewise, parental exposure to ATR caused transgenerational toxicity impairments. Interestingly, reproductive toxicity not development toxicity was transmitted to several generations (F1–F4), and the F2 generation showed the most notable changes. QRT-PCR results showed that genes related to DNA methylation 6mA (damt-1, nmad-1) and histone H3 methylation (mes-4, met-2, set-25, set-2, and utx-1) can also be passed on to offspring. The function of H3K4 and H3K9 methylation were explored by using loss-of-function mutants for set-2, set-25, and met-2. Transmissible reproductive toxicity was absent in met-2(n4256), set-2(ok952), and set-25(n5021) mutants, which suggests that the histone methyltransferases H3K4 and H3K9 activity are indispensable for the transgenerational effect of ATR. Finally, the downstream genes of DNA methylation and histone H3 methylation were determined. ATR upregulated the expression of ZC317.7, hsp-6, and hsp-60. Mitochondrial stress in parental generation dependent transcription 6mA modifiers may establish these epigenetic marks in progeny. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ATR" title="ATR">ATR</a>, <a href="https://publications.waset.org/abstracts/search?q=Caenorhabditis%20elegans" title=" Caenorhabditis elegans"> Caenorhabditis elegans</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-%2Ftrans-generation" title=" multi-/trans-generation"> multi-/trans-generation</a>, <a href="https://publications.waset.org/abstracts/search?q=reproductive%20toxicity" title=" reproductive toxicity"> reproductive toxicity</a> </p> <a href="https://publications.waset.org/abstracts/165179/dna-methylation-6ma-and-histone-methylation-involved-in-multi-trans-generational-reproductive-effects-in-caenorhabditis-elegans-induced-by-atrazine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165179.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">71</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1037</span> Absorbed Dose Estimation of 177Lu-DOTATOC in Adenocarcinoma Breast Cancer Bearing Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Zolghadri">S. Zolghadri</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mousavi-Daramoroudi"> M. Mousavi-Daramoroudi</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Yousefnia"> H. Yousefnia</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Abbasi-Davani"> F. Abbasi-Davani </a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, the absorbed dose of human organs after injection of <sup>177</sup>Lu-DOTATOC was studied based on the biodistribution of the complex in adenocarcinoma breast cancer bearing mice. For this purpose, the biodistribution of the radiolabelled complex was studied and compartmental modeling was applied to calculate the absorbed dose with high precision. As expected, <sup>177</sup>Lu-DOTATOC illustrated a notable specific uptake in tumor and pancreas, organs with high level of somatostatin receptor on their surface and the effectiveness of the radio-conjugate for targeting of the breast adenocarcinoma tumors was indicated. The elicited results of modeling were the exponential equations, and those are utilized for obtaining the cumulated activity data by taking their integral. The results also exemplified that non-target absorbed-doses such as the liver, spleen and pancreas were approximately 0.008, 0.004, and 0.039, respectively. While these values were so much lower than target (tumor) absorbed-dose, it seems due to this low toxicity, this complex is a good agent for therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%C2%B9%E2%81%B7%E2%81%B7Lu" title="¹⁷⁷Lu">¹⁷⁷Lu</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=compartmental%20modeling" title=" compartmental modeling"> compartmental modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=dosimetry" title=" dosimetry"> dosimetry</a> </p> <a href="https://publications.waset.org/abstracts/97772/absorbed-dose-estimation-of-177lu-dotatoc-in-adenocarcinoma-breast-cancer-bearing-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97772.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1036</span> Analysis of in Vitro Biocompatibility Studies of Silicate-Based Bioceramic Cements: A Scoping Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Olphiara%20Rodolpheza%20Alexandre">Olphiara Rodolpheza Alexandre</a>, <a href="https://publications.waset.org/abstracts/search?q=Carla%20David"> Carla David</a>, <a href="https://publications.waset.org/abstracts/search?q=Rafael%20Guerra%20Lund"> Rafael Guerra Lund</a>, <a href="https://publications.waset.org/abstracts/search?q=Nadia%20Ferreira"> Nadia Ferreira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to the increasing demand for biomaterials in the dental field, especially in endodontics, calcium silicate-based cements (CSCs) have gained prominence because of their biocompatibility and tissue regeneration capabilities. Originating from Mineral Trioxide Aggregate (MTA), the first bioceramic in endodontics derived from Portland cement, these materials are becoming increasingly prevalent in the market. For any drug released to the market, pharmacovigilance must ensure the absence of adverse health effects on consumers through rigorous toxicological testing. Although these materials have undergone in vitro and in vivo testing, such tests have typically been conducted over a limited period. Some effects may only become apparent after several years, and these studies are generally carried out on a non-specific population. However, the variety of calcium silicate-based products, including cement and sealers, raises questions about their toxicity, particularly considering potential long-term effects not addressed in existing studies. While the scientific literature includes comparative studies on the toxicity of these materials, the consistency of their conclusions is often controversial. Therefore, this project aims to map the scientific evidence from in vitro biocompatibility studies, including those investigating the toxicity of calcium silicate-based bioceramics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=toxicity" title="toxicity">toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity%20test" title=" toxicity test"> toxicity test</a>, <a href="https://publications.waset.org/abstracts/search?q=bioceramics" title=" bioceramics"> bioceramics</a>, <a href="https://publications.waset.org/abstracts/search?q=calcium%20silicate" title=" calcium silicate"> calcium silicate</a>, <a href="https://publications.waset.org/abstracts/search?q=genotoxicity" title=" genotoxicity"> genotoxicity</a> </p> <a href="https://publications.waset.org/abstracts/189472/analysis-of-in-vitro-biocompatibility-studies-of-silicate-based-bioceramic-cements-a-scoping-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189472.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">30</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1035</span> Effect of Auraptene on the Enzymatic Glutathione Redox-System in Nrf2 Knockout Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ludmila%20A.%20Gavriliuc">Ludmila A. Gavriliuc</a>, <a href="https://publications.waset.org/abstracts/search?q=Jerry%20McLarty"> Jerry McLarty</a>, <a href="https://publications.waset.org/abstracts/search?q=Heather%20E.%20Kleiner"> Heather E. Kleiner</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Michael%20Mathis"> J. Michael Mathis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Abstract -- Background: The citrus coumarine Auraptene (Aur) is an effective chemopreventive agent, as manifested in many models of diseases and cancer. Nuclear factor erythroid 2-related factor (Nrf2) is an important regulator of genes induced by oxidative stress, such as glutathione S-transferases, heme oxygenase-1, and peroxiredoxin 1, by activating the antioxidant response element (ARE). Genetic and biochemical evidence has demonstrated that glutathione (GSH) and glutathione-dependent enzymes, glutathione reductase (GR), glutathione peroxidases (GPs), glutathione S-transferases (GSTs) are responsible for the control of intracellular reduction-oxidation status and participate in cellular adaptation to oxidative stress. The effect of Aur on the activity of GR, GPs (Se-GP and Se-iGP), and content of GSH in the liver, kidney, and spleen is insufficiently explored. Aim: Our goal was the examination of the Aur influence on the redox-system of GSH in Nrf2 wild type and Nrf2 knockout mice via activation of Nrf2 and ARE. Methods: Twenty female mice, 10 Nrf2 wild-type (WT) and 10 Nrf2 (-/-) knockout (KO), were bred and genotyped for our study. The activity of GR, Se-GP, Se-iGP, GST, G6PD, CytP450 reductase, catalase (Cat), and content of GSH were analyzed in the liver, kidney, and spleen using Spectrophotometry methods. The results of the specific activity of enzymes and the amount of GSH were analyzed with ANOVA and Spearman statistical methods. Results: Aur (200 mg/kg) treatment induced hepatic GST, GR, Se-GP activity and inhibited their activity in the spleen of mice, most likely via activation of the ARE through Nrf2. Activation in kidney Se-GP and G6PD by Aur is also controlled, apparently through Nrf2. Results of the non-parametric Spearman correlation analysis indicated the strong positive correlation between GR and G6PD only in the liver in WT control mice (r=+0.972; p < 0.005) and in the kidney KO control mice (r=+0.958; p < 0.005). The observed low content of GSH in the liver of KO mice indicated an increase in its participation in the neutralization of toxic substances with the absence of induction of GSH-dependent enzymes, such as GST, GR, Se-GP, and Se-iGP. Activation of CytP450 in kidney and spleen and Cat in the liver in KO mice probably revealed another regulatory mechanism for these enzymes. Conclusion: Thereby, obtained results testify that Aur can modulate the activity of genes and antioxidant enzymatic redox-system of GSH, responsible for the control of intracellular reduction-oxidation status. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=auraptene" title="auraptene">auraptene</a>, <a href="https://publications.waset.org/abstracts/search?q=glutathione" title=" glutathione"> glutathione</a>, <a href="https://publications.waset.org/abstracts/search?q=GST" title=" GST"> GST</a>, <a href="https://publications.waset.org/abstracts/search?q=Nrf2" title=" Nrf2"> Nrf2</a> </p> <a href="https://publications.waset.org/abstracts/133552/effect-of-auraptene-on-the-enzymatic-glutathione-redox-system-in-nrf2-knockout-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/133552.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">149</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1034</span> Toxicity Identification and Evaluation for the Effluent from Seawater Desalination Facility in Korea Using D. magna and V. fischeri</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sung%20Jong%20Lee">Sung Jong Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hong%20Joo%20Ha"> Hong Joo Ha</a>, <a href="https://publications.waset.org/abstracts/search?q=Chun%20Sang%20Hong"> Chun Sang Hong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, the interests on the impacts of industrial wastewater on aquatic ecosystem have increased with concern about ecosystem protection and human health. Whole effluent toxicity tests are used to monitor toxicity by unknown toxic chemicals as well as conventional pollutants from industrial effluent discharges. This study describes the application of TIE (toxicity identification evaluation) procedures to an acutely toxic effluent from a Seawater desalination facility in industrial complex which was toxic to Daphnia magna. In TIE phase I (characterization step), the toxic effects by heavy metals, organic compounds, oxidants, volatile organic compounds, suspended solids and ammonia were screened and revealed that the source of toxicity is far from these toxicants group. Chemical analysis (TIE phase II) on TDS showed that the concentration of chloride ion (24,215 ~ 29,562 mg/L) was substantially higher than that predicted from EC50 for D. magna. In confirmation step (TIE phase III), chloride ion was demonstrated to be main toxicant in this effluent by the spiking approach, species sensitivity approach, and deletion approach. Calcium, potassium, magnesium, sodium, fluorine, sulfate ion concentration was not shown toxicity from D. magna. Finally, we concluded that chloride was the most contributing toxicant in the waste water treatment plant. Further research activities are needed for technical support of toxicity identification and evaluation on the various types of wastewater treatment plant discharge in Korea. Acknowledgement: This research was supported by a grant (16IFIP-B089911-03) from Plant Research Program funded by Ministry of Land, Infrastructure and Transport of Korean government. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=TIE" title="TIE">TIE</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20magna" title=" D. magna"> D. magna</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20fischeri" title=" V. fischeri"> V. fischeri</a>, <a href="https://publications.waset.org/abstracts/search?q=seawater%20desalination%20facility" title=" seawater desalination facility"> seawater desalination facility</a> </p> <a href="https://publications.waset.org/abstracts/53156/toxicity-identification-and-evaluation-for-the-effluent-from-seawater-desalination-facility-in-korea-using-d-magna-and-v-fischeri" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53156.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">259</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1033</span> Splenic Artery Aneurysms: A Rare, Insidious Cause of Abdominal Pain</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Christopher%20Oyediran">Christopher Oyediran</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicola%20Ubayasiri"> Nicola Ubayasiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Christopher%20Gough"> Christopher Gough</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Splenic artery aneurysms are often clinically occult, occasionally identified incidentally with imaging. The pathogenesis of aneurysms is complex, but certain factors are thought to contribute to their development. Given the potential fatal complications of rupture, a high index of suspicion is required to make an early diagnosis. We present a case of a 36-year-old female with a history of endometriosis and multiple sclerosis who presented to the Emergency Department with sudden onset epigastric pain and collapse. On arrival, she was pale and clammy with profound tachycardia and hypotension. An ultrasound done in the resuscitation department revealed abdominal free fluid. She was resuscitated with blood and transferred for emergent laparotomy. Laparotomy revealed massive haemoperitoneum from the spleen. She underwent emergency splenectomy and inspection of the spleen revealed a splenic artery aneurysm. She received our massive transfusion protocol followed by a short stay on ITU, making a good post-operative recovery and was discharged home a week later. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aneurysm" title="aneurysm">aneurysm</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20chorionic%20gonadotrophin%20%28hCG%29" title=" human chorionic gonadotrophin (hCG)"> human chorionic gonadotrophin (hCG)</a>, <a href="https://publications.waset.org/abstracts/search?q=resuscitation" title=" resuscitation"> resuscitation</a>, <a href="https://publications.waset.org/abstracts/search?q=laparotomy" title=" laparotomy"> laparotomy</a> </p> <a href="https://publications.waset.org/abstracts/18273/splenic-artery-aneurysms-a-rare-insidious-cause-of-abdominal-pain" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18273.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">431</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1032</span> Antibacterial Activities, Chemical Constitutes and Acute Toxicity of Peganum Harmala L. Essential Oil</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samy%20Selim">Samy Selim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural products are still major sources of innovative therapeutic agents for various conditions, including infectious diseases. Peganum harmala L. oil had wide range uses as traditional medicinal plants. The current study was designed to evaluate the antibacterial activity of P. harmala essential oil. The chemical constitutes and toxicity of these oils was also determined to obtain further information on the correlation between the chemical contents and antibacterial activity. The antibacterial effect of the essential oils of P. harmala oil was studied against some foodborne pathogenic bacteria species. The oil of plant was subjected to gas chromatography-mass spectrometry (GC/MS). The impact of oils administration on the change in rate of weight gain and complete blood picture in hamsters were investigated. P. harmala oil had strong antibacterial effect against bacterial species especially at minimum inhibitory concentration (MIC) less than 75.0 μg/ml. From the oil of P. harmala, forty one compounds were identified, and the major constituent was 1-hexyl-2-nitrocyclohexane (9.07%). Acute toxicity test was performed on hamsters and showed complete survival after 14 days, and there were no toxicity symptoms occurred. This study demonstrated that these essential oils seemed to be destitute of toxic effect which could compromise the medicinal use of these plants in folk medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=analysis%20mass%20spectrometry" title="analysis mass spectrometry">analysis mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial%20activities" title=" antibacterial activities"> antibacterial activities</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title=" acute toxicity"> acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20constitutes" title=" chemical constitutes"> chemical constitutes</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20chromatography" title=" gas chromatography"> gas chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=weight%20gain" title=" weight gain"> weight gain</a>, <a href="https://publications.waset.org/abstracts/search?q=Peganum%20harmala" title=" Peganum harmala"> Peganum harmala</a> </p> <a href="https://publications.waset.org/abstracts/2219/antibacterial-activities-chemical-constitutes-and-acute-toxicity-of-peganum-harmala-l-essential-oil" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2219.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">484</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=spleen%20toxicity&page=2">2</a></li> <li class="page-item"><a class="page-link" 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