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dcrname ="iwDCR0_281318"> <header class="-padding--horizontal" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="content-header content-container -width--wide -centered"> <div class="tags"> <ul class="tag__list"> <li class="tag__item"> <a class="tag__link" href="/digestive-health/topic.aspx?id=1040">Bowel Disease</a> </li> <li class="tag__item"> <a class="tag__link" href="/digestive-health/specialty.aspx?id=1007">Digestive Health</a> </li> </ul> </div> <h1 class="content-header__heading" itemprop="name">Greater Fruit and Vegetable Intake Linked to Lower Risk of Diverticulosis</h1> <div class="content-header__metadata"> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2020-10-08" itemprop="datePublished">Published on October 8, 2020 </time> </p> <p data-module="share-links"> </p> <p class="citation"> Originally published on <cite itemprop="citation"><a href="https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01374-0">BMC Gastroenterol</a></cite> </p> </div> </div> </header> <div class="-padding--vertical -padding--horizontal"> <div class="layout-columns -width--wide -centered"> <div class="layout-columns__main"> <div class="layout-columns__main__content"> <div class="content-summary"> <h3 class="content-summary__heading">Key findings</h3> <ul> <li>This study analyzed food frequency data reported by 549 patients, of whom 245 later developed diverticulosis</li> <li>Compared with people who ate less than five servings of vegetables per week, those who ate five to seven servings of vegetables per week had 16% less risk of diverticulosis, and those who ate more than one serving per day had 38% less risk</li> <li>Compared with people who ate less than five servings of fruit per week, those who ate five to seven servings of fruit per week had 19% less risk of diverticulosis, and those who ate more than one serving per day had 40% less risk</li> <li>No association was detected between prevalent diverticulosis and intake of red/processed meat</li> </ul> </div> <p></p><div class="article__signup-container"> <div class="email-signup-inline__container -background--white"> <style> #email-signup-inline { /* 540px */ background-image: url(/assets/raw/email-signup/cardiovascular-sub-callout.jpg); } @media only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-moz-min-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) { #email-signup-inline { /* 1080 width */ background-image: url(/assets/raw/email-signup/cardiovascular-sub-callout.jpg); } } </style> <div class="content-container -width--wide -centered email-signup-inline__wrapper" id="email-signup-inline"> <div class="email-signup-inline__logo"> 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href="https://massgeneral.tfaforms.net/dist/form-builder/5.0.0/wforms-layout.css?v=20484c23150f9374e828ae7e95c879908749f33b" rel="stylesheet" type="text/css" /> <link href="https://massgeneral.tfaforms.net/uploads/themes/theme-7.css" rel="stylesheet" type="text/css" /> <link href="https://massgeneral.tfaforms.net/dist/form-builder/5.0.0/wforms-jsonly.css?v=20484c23150f9374e828ae7e95c879908749f33b" rel="alternate stylesheet" title="This stylesheet activated by javascript" type="text/css" /> <script type="text/javascript" src="https://massgeneral.tfaforms.net/wForms/3.11/js/wforms.js?v=20484c23150f9374e828ae7e95c879908749f33b"></script> <script type="text/javascript"> wFORMS.behaviors.prefill.skip = false; </script> <script type="text/javascript" src="https://massgeneral.tfaforms.net/wForms/3.11/js/localization-en_US.js?v=20484c23150f9374e828ae7e95c879908749f33b"></script>  <div class="wFormContainer" > <div class=""> <div class="wForm" id="524-WRPR" data-language="en_US" dir="ltr"> <div class="codesection" id="code-524"></div> <form method="post" action="https://massgeneral.tfaforms.net/api_v2/workflow/processor" class="hintsBelow labelsAbove" id="524"> <div class="oneField field-container-D " id="tfa_9-D"> <div aria-live="assertive"> <p class="marketo-signup__error"> Error: Please enter a valid email address. </p> </div> <p class="marketo-signup__input" data-module="label-float"> <label for="email-address"> Email Address </label> <input type="email" id="tfa_9" name="tfa_9" value="" data-marketo="email" > <button class="fat-button" type="submit" data-label="Submit" class="primaryAction" id="submit_button" value="Submit"> <span class="a11y-sr-only">Submit</span> </button> </p> <input type="hidden" id="tfa_10" name="tfa_10" value="Sub_Gastro" class=""><input type="hidden" id="tfa_12" name="tfa_12" value="AiM Sub Box" class=""> </div> <div style="clear:both"></div> <input type="hidden" value="524" name="tfa_dbFormId" id="tfa_dbFormId"> <input type="hidden" value="" name="tfa_dbResponseId" id="tfa_dbResponseId"> <input type="hidden" value="43363a66175b5664ffab7ef336bf1caa" name="tfa_dbControl" id="tfa_dbControl"> <input type="hidden" value="" name="tfa_dbWorkflowSessionUuid" id="tfa_dbWorkflowSessionUuid"> <input type="hidden" value="5" name="tfa_dbVersionId" id="tfa_dbVersionId"> <input type="hidden" value="" name="tfa_switchedoff" id="tfa_switchedoff"> </form> </div> </div> </div> <script id="open-telemetry-script" type="text/javascript" src="https://massgeneral.tfaforms.net/dist/open-telemetry/open-telemetry.152f594b0ae29ae89d4a.js" data-customer-id="1118" data-exporter-url="https://us-east-1-otel.formassembly.com/v1/traces" data-exporter-console="0" ></script> <script src="https://massgeneral.tfaforms.net/api_v2/sst/copy-and-paste"></script> </div> </div> </div> <p>Nearly a third of U.S. adults over 50 develop colonic diverticulosis, with the potential for costly complications. The role of diet in this condition remains poorly understood, as previous studies have yielded conflicting results.</p> <p>MD students Benjamin Maxner and Jessica McGoldrick, and Gastroenterologist <a href="https://advances.massgeneral.org/contributors/contributor.aspx?id=1324">Hamed Khalili, MD, MPH</a>, all of the <a href="https://www.massgeneral.org/medicine/gastroenterology">Division of Gastroenterology</a> at Massachusetts General Hospital, analyzed food frequency data gathered before the detection of diverticula. Along with their colleagues, they determined that a greater intake of fruits and vegetables is associated with an increased risk of diverticulosis. Their report appears in <em><a href="https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01374-0" target="_blank" rel="noopener noreferrer">BMC Gastroenterology</a></em>.</p> <h2>Study Details</h2> <p>Mass General maintains the <a href="https://rally.massgeneralbrigham.org/study/9909" target="_blank" rel="noopener noreferrer">Gastrointestinal Disease and Endoscopy Registry (GIDER)</a>, which stores results of comprehensive dietary, lifestyle and medical history questionnaires that patients complete before screening or surveillance colonoscopy. Patients are excluded if they have a history of gastrointestinal cancer, hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, inflammatory bowel disease, known bleeding disorders or antibiotic use within the prior two months.</p> <h2>Rates of Diverticulosis</h2> <p>Among 549 patients enrolled in GIDER, the researchers confirmed diverticulosis in 245 (45%). The rate varied from 57% among those who consumed fruit and vegetables less than five times per week to 32% among those who consumed more than one serving per day. Fruit and vegetable intake were significantly associated with the prevalence of diverticulosis (Ptrend = .007 and .008, respectively).</p> <h2>Multivariable Analyses</h2> <p>The results were adjusted for other dietary patterns, age, sex, BMI, smoking, physical activity, regular use of nonsteroidal anti-inflammatory drugs and bowel movement frequency. Compared with participants who ate less than five servings per week, the prevalence ratio of diverticulosis was:</p> <h4>Vegetables</h4> <ul> <li><strong>0.84 (95% CI, 0.60–1.17)</strong> for those who ate five to seven servings per week</li> <li><strong>0.62 (95% CI, 0.44–0.89)</strong> for more than one serving per day</li> </ul> <h4>Fruit</h4> <ul> <li><strong>0.81 (95% CI, 0.58–1.11)</strong> for five to seven servings of per week</li> <li><strong>0.60 (95% CI, 0.41–0.87)</strong> for more than one serving per day</li> </ul> <p>For fruit and vegetable intake considered together, the prevalence ratio was 0.58 (95% CI, 0.39–0.87) for more than one serving per day compared with one serving or less.</p> <p>No association was detected between prevalent diverticulosis and intake of red/processed meat.</p> <h2>Counseling Patients</h2> <p>As the proportion of older people in the U.S. continues to grow, the prevalence and cost of diverticulosis will probably increase. This eventuality makes reducing modifiable risk factors critical. Clinicians should call patients' attention to the role of fruit and vegetable intake in preventing diverticulosis.</p> <p></p> <figure class="stat" data-module="stat" data-plaintext="16% less risk of diverticulosis with 5–7 servings of vegetables per week compared with <5 per week"><span class="stat__number"><span data-stat-number="">16</span>%</span> <figcaption class="stat__caption">less risk of diverticulosis with 5–7 servings of vegetables per week compared with <5 per week <p data-module="share-links"></p> </figcaption> </figure> <figure class="stat" data-module="stat" data-plaintext="38% less risk of diverticulosis with >1 serving of vegetables per day compared with <5 per week"><span class="stat__number"><span data-stat-number="">38</span>%</span> <figcaption class="stat__caption">less risk of diverticulosis with >1 serving of vegetables per day compared with <5 per week <p data-module="share-links"></p> </figcaption> </figure> <figure class="stat" data-module="stat" data-plaintext="19% less risk of diverticulosis with 5–7 servings of fruit per week compared with <5 per week"><span class="stat__number"><span data-stat-number="">19</span>%</span> <figcaption class="stat__caption">less risk of diverticulosis with 5–7 servings of fruit per week compared with <5 per week <p data-module="share-links"></p> </figcaption> </figure> <figure class="stat" data-module="stat" data-plaintext="40% less risk of diverticulosis with >1 serving of fruit per day compared with <5 per week"><span class="stat__number"><span data-stat-number="">40</span>%</span> <figcaption class="stat__caption">less risk of diverticulosis with >1 serving of fruit per day compared with <5 per week <p data-module="share-links"></p> </figcaption> </figure> <p></p> <p></p> <p></p> <p></p> <p></p><p class="fat-link__wrapper u-text-right"> <a class="fat-link -caret -large" href="https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01374-0">view original journal article <em>Subscription may be required</em></a> </p> <div class="article-attribution" itemscope itemtype="http://schema.org/ScholarlyArticle"> <p class="article-attribution__logo" itemscope itemtype="http://schema.org/Periodical"> <a href="https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01374-0"> <span class="a11y-sr-only" itemprop="name">BMC Gastroenterol</span> </a> </p> <p class="article-attribution__metadata" itemscope itemtype="http://schema.org/PublicationIssue"> <span> Journal Article Published: <time datetime="2020-07-11" itemprop="datePublished">July 11, 2020</time> </span> </p> </div> <p class="cta">Visit the <a href="https://www.massgeneral.org/medicine/gastroenterology/">Division of Gastroenterology</a></p> <p class="cta">Refer a patient to the <a href="https://www.massgeneral.org/medicine/gastroenterology/appointments-and-referrals/referral-request">Division of Gastroenterology</a></p> </div> </div> <aside class="layout-columns__sidebar -article__contributors"> <div class="layout-columns__sidebar__content"> <div class="profile-compact__wrapper"> <p class="u-no-margin"> <strong>Contributors</strong> </p> <div class="profile -compact" itemscope itemtype="http://schema.org/Person"> <div class="profile__content"> <h3 class="profile__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1324" itemprop="url">Hamed Khalili, MD, MPH ›</a></h3><p class="profile__title" itemprop="jobTitle">Gastroenterologist, Clinical and Translational Epidemiology Unit, Director of Clinical Research in Inflammatory Bowel Disease in the Division of Gastroenterology, Associate Professor of Medicine, Harvard Medical School</p> </div> <p class="profile__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/hamed_khalili_advances.png, /assets/images/contributors/hamed_khalili_advances_2x.png 2x" src="/assets/images/contributors/hamed_khalili_advances.png"> </p> </div> </div> </div> </aside> <section 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