JCM | Special Issue : Advances in Epidemiological and Statistical Methods for Clinical Research

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<option value="microwave" > Microwave </option> <option value="minerals" > Minerals </option> <option value="mining" > Mining </option> <option value="modelling" > Modelling </option> <option value="mmphys" > Modern Mathematical Physics </option> <option value="molbank" > Molbank </option> <option value="molecules" > Molecules </option> <option value="mti" > Multimodal Technologies and Interaction (MTI) </option> <option value="muscles" > Muscles </option> <option value="nanoenergyadv" > Nanoenergy Advances </option> <option value="nanomanufacturing" > Nanomanufacturing </option> <option value="nanomaterials" > Nanomaterials </option> <option value="ndt" > NDT </option> <option value="network" > Network </option> <option value="neuroglia" > Neuroglia </option> <option value="neurolint" > Neurology International </option> <option value="neurosci" > NeuroSci </option> <option value="nitrogen" > Nitrogen </option> <option value="ncrna" > Non-Coding RNA (ncRNA) </option> <option 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This special issue belongs to the section "<a href="/journal/jcm/sections/Clinical_Research_Methods">Clinical Research Methods</a>".<span data-section-id="2468"></span></p> <p style="padding:0.5em 0;"> <span class="si-deadline"> Deadline for manuscript submissions: <b>closed (31 January 2025)</b> | Viewed by 1268 </span> <br/> </p> </div> <div style="clear: both;"></div> <div class="sharingLinks"> <h2>Share This Special Issue</h2> <div class="social-media-links" style="text-align: left;"><a href="/cdn-cgi/l/email-protection#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" title="Email"> <i class="fa fa-envelope-square" style="font-size: 30px;"></i> </a> <a href="https://twitter.com/intent/tweet?text=Advances+in+Epidemiological+and+Statistical+Methods+for+Clinical+Research&hashtags=mdpijcm&url=https%3A%2F%2Fwww.mdpi.com%2Fsi%2F207842&via=JCM_MDPI" onclick="windowOpen(this.href,600,800); 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clinical research methodology; epidemiology; evidence based medicine; evidence synthesis; medical statistics; meta-analysis; systematic reviews"> <div class="editor-div__content smaller-pictures"> <div class='profile-card-drop' data-dropdown='profile-card-drop42871' data-options='is_hover:true, hover_timeout:5000'> <div class="sciprofiles-link" style="display: inline-block"><div class="sciprofiles-link__link"><img class="sciprofiles-link__image" src="/data/editors/editor_42871.png?1718605627" style= "width: auto; height: 16px; border-radius: 50%;"><span class="sciprofiles-link__name"> Dr. Stefanos Bonovas </span></div></div> </div> <div id="profile-card-drop42871" data-dropdown-content class="f-dropdown content profile-card-content" aria-hidden="true" tabindex="-1"> <div class="profile-card__title "> <div class="sciprofiles-link" style="display: inline-block"><div class="sciprofiles-link__link"><img class="sciprofiles-link__image" src="/data/editors/editor_42871.png?1718605627" style= "width: auto; height: 16px; border-radius: 50%;"><span class="sciprofiles-link__name"> Dr. Stefanos Bonovas </span></div></div> </div> <div class="profile-card__buttons" style="margin-bottom: 10px;"> <a href="https://sciprofiles.com/profile/1156852?utm_source=mdpi.com&utm_medium=website&utm_campaign=avatar_name" class="button button--color-inversed" target="_blank"> SciProfiles </a> <a href="https://scilit.com/scholars?q=Stefanos%20Bonovas" class="button button--color-inversed" target="_blank"> Scilit </a> <a href="https://www.preprints.org/search?search1=Stefanos%20Bonovas&field1=authors" class="button button--color-inversed" target="_blank"> Preprints.org </a> <a href="https://scholar.google.com/scholar?q=Stefanos%20Bonovas" class="button button--color-inversed" target="_blank" rels="noopener noreferrer"> Google Scholar </a> </div> </div> <br class="show-for-small-only" /> <a class="inline-spacer toEncode emailCaptcha" href="" data-editor-id="42871">E-Mail</a> <a class="inline-spacer" href="https://www.hunimed.eu/professors-researchers-fellows/stefanos-bonovas/" target="_blank" rel="noopener noreferrer">Website</a> <br/> <i>Guest Editor</i><br> </div> <div style="clear: both;"></div> <div class="editor-div__content smaller-pictures"> 1. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy<br/> 2. IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy<br> <b>Interests:</b> biostatistics; clinical research methodology; epidemiology; evidence based medicine; evidence synthesis; medical statistics; meta-analysis; systematic reviews<br> <a href="#" id="editor_contrib_42871" onclick="div_toggle(this.id); return false;">Special Issues, Collections and Topics in MDPI journals</a> <div id="div_editor_contrib_42871" style="display: none"> Special Issue in <a href="/journal/jcm/special_issues/State-of-Art_in_Inflammatory_Bowel_Disease"> <i>Journal of Clinical Medicine</i>: State-of-the-Art in Inflammatory Bowel Disease</a><br> Special Issue in <a href="/journal/ijerph/special_issues/LIUOZYTYN8"> <i>International Journal of Environmental Research and Public Health</i>: Editorial Board Members' Collection Series: Real World—Big Data Analytics with Applications in Ecology, Environmental Health, and Public Health</a><br> Special Issue in <a href="/journal/jcm/special_issues/SWVY3375T7"> <i>Journal of Clinical Medicine</i>: Reducing Modifiable Risk Factors to Prevent and Control Non-communicable Diseases</a><br> </div> </div> </div> <div class="generic-item editor-div" data-filter="daniele piovani biostatistics; prediction modelling; evidence synthesis; clinical research methodology; epidemiology; evidence based medicine"> <div class="editor-div__content smaller-pictures"> <div class='profile-card-drop' data-dropdown='profile-card-drop337138' data-options='is_hover:true, hover_timeout:5000'> <div class="sciprofiles-link" style="display: inline-block"><div class="sciprofiles-link__link"><img class="sciprofiles-link__image" src="/bundles/mdpisciprofileslink/img/unknown-user.png" style="width: auto; height: 16px; border-radius: 50%;"><span class="sciprofiles-link__name"> Dr. Daniele Piovani </span></div></div> </div> <div id="profile-card-drop337138" data-dropdown-content class="f-dropdown content profile-card-content" aria-hidden="true" tabindex="-1"> <div class="profile-card__title "> <div class="sciprofiles-link" style="display: inline-block"><div class="sciprofiles-link__link"><img class="sciprofiles-link__image" src="/bundles/mdpisciprofileslink/img/unknown-user.png" style="width: auto; height: 16px; border-radius: 50%;"><span class="sciprofiles-link__name"> Dr. Daniele Piovani </span></div></div> </div> <div class="profile-card__buttons" style="margin-bottom: 10px;"> <a href="https://sciprofiles.com/profile/1065631?utm_source=mdpi.com&utm_medium=website&utm_campaign=avatar_name" class="button button--color-inversed" target="_blank"> SciProfiles </a> <a href="https://scilit.com/scholars?q=Daniele%20Piovani" class="button button--color-inversed" target="_blank"> Scilit </a> <a href="https://www.preprints.org/search?search1=Daniele%20Piovani&field1=authors" class="button button--color-inversed" target="_blank"> Preprints.org </a> <a href="https://scholar.google.com/scholar?q=Daniele%20Piovani" class="button button--color-inversed" target="_blank" rels="noopener noreferrer"> Google Scholar </a> </div> </div> <br class="show-for-small-only" /> <a class="inline-spacer toEncode emailCaptcha" href="" data-editor-id="337138">E-Mail</a> <a class="inline-spacer" href="https://www.hunimed.eu/it/member/daniele-piovani/" target="_blank" rel="noopener noreferrer">Website</a> <br/> <i>Guest Editor</i><br> </div> <div style="clear: both;"></div> <div class="editor-div__content smaller-pictures"> 1. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy<br/> 2. IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy<br> <b>Interests:</b> biostatistics; prediction modelling; evidence synthesis; clinical research methodology; epidemiology; evidence based medicine<br> <a href="#" id="editor_contrib_337138" onclick="div_toggle(this.id); return false;">Special Issues, Collections and Topics in MDPI journals</a> <div id="div_editor_contrib_337138" style="display: none"> Special Issue in <a href="/journal/jcm/special_issues/State-of-Art_in_Inflammatory_Bowel_Disease"> <i>Journal of Clinical Medicine</i>: State-of-the-Art in Inflammatory Bowel Disease</a><br> Special Issue in <a href="/journal/jcm/special_issues/SWVY3375T7"> <i>Journal of Clinical Medicine</i>: Reducing Modifiable Risk Factors to Prevent and Control Non-communicable Diseases</a><br> </div> </div> </div> </div> <h2><a name="info"></a>Special Issue Information</h2> <div> <p>Dear Colleagues,</p> <p>Our Special Issue, entitled “Advances in Epidemiological and Statistical Methods for Clinical Research”, will focus on presenting the latest advancements in epidemiological and statistical methodologies tailored for clinical research. We encourage all authors to submit articles related to a wide range of methodologies, including novel study designs, advanced statistical techniques, causal inference methods, meta-analysis and systematic review methods, strategies for addressing bias and confounding in observational studies, the development and validation of prediction models, and methodological challenges and solutions in specific areas of clinical research. Articles will be considered for publication in this Special Issue only if they are relevant to our clinical research. Contributions will be part of an ongoing dialogue on methodological advances in clinical research and facilitate the translation of research findings into improved outcomes for patients.</p> <p>Dr. Stefanos Bonovas<br />Dr. Daniele Piovani<br /><em>Guest Editors</em></p> <p><p><strong>Manuscript Submission Information</strong><p> <p>Manuscripts should be submitted online at <a href="https://www.mdpi.com/">www.mdpi.com</a> by <a href="https://www.mdpi.com/user/register/">registering</a> and <a href="https://www.mdpi.com/user/login/">logging in to this website</a>. Once you are registered, <a href="https://susy.mdpi.com/user/manuscripts/upload/?journal=jcm">click here to go to the submission form</a>. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. 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margin-right: 15px; margin-bottom: 10px;">Export citation of selected articles as:</span> <br class="show-for-medium-down" /> <div class="listing-export"> <select class="chosen-select inline" name="format_top"> <option value="plaintext"> Plain Text </option> <option value="bibtex"> BibTeX </option> <option value="bibtex_no_abstract"> BibTeX (without abstracts) </option> <option value="endnote"> Endnote </option> <option value="endnote_no_abstract"> Endnote (without abstracts) </option> <option value="tab_delimited"> Tab-delimited </option> <option value="ris"> RIS </option> </select> </div> <input type="submit" value="Export" class="articleBrowserSubmit button button--color-inversed" id="articleBrowserExport_top"> </div> </div> <a id="link-export-modal-nothing-selected" data-reveal-id="export-modal-nothing-selected" style="display: none;"></a> <div id="export-modal-nothing-selected" class="reveal-modal reveal-modal-new reveal-modal-new--small" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog"> <div class="row"> <div class="small-12 columns"> <h2>Error</h2> Oops... you haven't selected anything for export. </div> <div class="small-12 columns"> <a class="button button--color" onclick="$(this).closest('.reveal-modal-new').foundation('reveal', 'close'); return false;">Ok</a> </div> </div> <a class="close-reveal-modal" aria-label="Close"> <i class="material-icons">clear</i> </a> </div> </div> <div> <div style="clear: both"></div> </div> </div> </div> <div class="generic-item type-section" id=Research> <h2>Research</h2> <div style="margin-top: 15px;"> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1536108" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 496 KiB   </span> <a href="/2077-0383/13/23/7374/pdf?version=1733244151" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Validation of Psychometric Properties of Partners in Health Scale for Heart Failure" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7374">Validation of Psychometric Properties of Partners in Health Scale for Heart Failure</a> <div class="authors"> by <span class="inlineblock "><strong>Pupalan Iyngkaran</strong>, </span><span class="inlineblock "><strong>David Smith</strong>, </span><span class="inlineblock "><strong>Craig McLachlan</strong>, </span><span class="inlineblock "><strong>Malcolm Battersby</strong>, </span><span class="inlineblock "><strong>Maximilian De Courten</strong> and </span><span class="inlineblock "><strong>Fahad Hanna</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7374; <a href="https://doi.org/10.3390/jcm13237374">https://doi.org/10.3390/jcm13237374</a> - 3 Dec 2024 </div> Viewed by 769 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Congestive heart failure (CHF) is a complex chronic disease, and it is associated with a second comorbid condition in more than half of cases. Self-management programs can be specific to CHF or generic for chronic diseases. Several tools have been validated for <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7374/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Congestive heart failure (CHF) is a complex chronic disease, and it is associated with a second comorbid condition in more than half of cases. Self-management programs can be specific to CHF or generic for chronic diseases. Several tools have been validated for CHF. Presently, there are no established generic instruments that are validated for measuring self-management in CHF. <b>Objective:</b> This study aims to evaluate the internal reliability and construct validity (psychometric properties) of the Partners in Health (PIH) scale for patients with congestive heart failure, a generic chronic disease self-management tool. <b>Methods:</b> The study included 210 adult CHF patients [120 with heart failure with reduced ejection fraction (HfrEF), 90 with preserved ejection fraction (HfpEF)], from Community Cardiology Outpatients in West Melbourne, Australia, who were treated in community cardiology and were included between May 2022 and Jan 2024. The screened patient population were diagnosed with CHF and were eligible for an SGLT-2 inhibitor. Cohort analysis used the Bayesian confirmatory factor analysis to evaluate the a priori four-factor structure. Omega coefficients and 95% credible intervals (CI) were used to assess internal reliability. <b>Results:</b> In the CHF (HFrEF) and preserved ejection fraction (HFpEF) cohorts, participants’ mean [standard deviation (SD)] age was 66.8 (13.5) and 71.3 (9.76) years. Description of study sociodemographics highlighted that 88% and 52% of patients were male, there was a BMI > 50% in both cohorts, eGFR > 60 mL/min were 59% and 74%, and LVEF < 40% and > 50% were 99% and 100%, respectively. Model fit for the hypothesised model was adequate (posterior predictive <i>p</i> = 0.073) and all hypothesised factor loadings were substantial (>0.6) and significant (<i>p</i> < 0.001). Omega coefficients (95% CI) for the PIH subscales of Knowledge, Partnership, Management and Coping were 0.84 (0.79–0.88), 0.79 (0.73–0.84), 0.89 (0.85–0.91) and 0.84 (0.79–0.88), respectively. <b>Conclusion:</b> This study is original in confirming the dimensionality, known-group validity, and reliability of the PIH scale for measuring generic self-management in outpatients with CHF syndrome. <a href="/2077-0383/13/23/7374">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/379JR3FQU5 ">Advances in Epidemiological and Statistical Methods for Clinical Research</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7374/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1536108-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07374/article_deploy/html/images/jcm-13-07374-g001-550.jpg?1733244236" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1536108-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07374/article_deploy/html/images/jcm-13-07374-g001-550.jpg?1733244236" title=" <strong>Figure 1</strong><br/> <p>Flowchart. HFpEF鈥攈eart failure with preserved ejection fraction; HFrEF鈥攈eart failure with reduced ejection fraction; n = number.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7374'>Full article</a></strong> "></a></div> </div> </div> <div class="row footer"> <div class="listing-select-options"> <div class="columns small-12"> <div class="select generic-item"> <a href="#" class="export-options-show export-element export-expanded"> Show export options <i class="material-icons">expand_more</i> </a> <a href="#" class="export-options-show export-element"> Show export options <i class="material-icons">expand_less</i> </a> </div> <div class="listing-export-options export-element"> <div class="export-element" style="margin-top: 10px; margin-bottom: 10px;"> <input type="checkbox" class="selector selectUnselectAll bb-checkbox" id="selectUnselectAll" data-select-all="article-listing"> <div class="indented bb-indented"> Select all </div> </div> <div class="indented1"> <span style="display: inline-block; margin-right: 15px; margin-bottom: 10px;">Export citation of selected articles as:</span> <br class="show-for-medium-down" /> <div class="listing-export"> <select class="chosen-select inline" name="format_bottom"> <option value="plaintext"> Plain Text </option> <option value="bibtex"> BibTeX </option> <option value="bibtex_no_abstract"> BibTeX (without abstracts) </option> <option value="endnote"> Endnote </option> <option value="endnote_no_abstract"> Endnote (without abstracts) </option> <option value="tab_delimited"> Tab-delimited </option> <option value="ris"> RIS </option> </select> </div> <input type="submit" value="Export" class="articleBrowserSubmit button button--color-inversed" id="articleBrowserExport_bottom"> </div> <div style="border-top: 1px solid #ededed; height: 5px; margin-top: 15px;">   </div> </div> <a id="link-export-modal-nothing-selected" data-reveal-id="export-modal-nothing-selected" style="display: none;"></a> <div id="export-modal-nothing-selected" class="reveal-modal reveal-modal-new reveal-modal-new--small" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog"> <div class="row"> <div class="small-12 columns"> <h2>Error</h2> Oops... you haven't selected anything for export. </div> <div class="small-12 columns"> <a class="button button--color" onclick="$(this).closest('.reveal-modal-new').foundation('reveal', 'close'); return false;">Ok</a> </div> </div> <a class="close-reveal-modal" aria-label="Close"> <i class="material-icons">clear</i> </a> </div> </div> <div> <div class="columns large-12 medium-12 small-12"> Displaying articles 1-1 </div> <div style="clear: both"></div> </div> </div> </div> </div> </form> </div> <span data-special-issue-id="207842"></span> </div> </div> </div> </div> </div> </section> <div id="footer"> <div class="journal-info"> <span> <em><a class="Var_JournalInfo" href="/journal/jcm">J. 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JCM | Special Issue : Advances in Epidemiological and Statistical Methods for Clinical Research