Genistein Suppresses Doxorubicin Associated Genotoxicity in Human Lymphocytes

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Associated Genotoxicity in Human Lymphocytes</title> <meta name="description" content="Genistein Suppresses Doxorubicin Associated Genotoxicity in Human Lymphocytes"> <meta name="keywords" content="apoptosis, DNA damage markers, doxorubicin, genistein, genotoxicity, human lymphocyte culture"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img 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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Genistein Suppresses Doxorubicin Associated Genotoxicity in Human Lymphocytes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tanveer%20Beg">Tanveer Beg</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasir%20H.%20Siddique"> Yasir H. Siddique</a>, <a href="https://publications.waset.org/abstracts/search?q=Gulshan%20Ara"> Gulshan Ara</a>, <a href="https://publications.waset.org/abstracts/search?q=Asfar%20S.%20Azmi"> Asfar S. Azmi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Afzal"> Mohammad Afzal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Doxorubicin is a well-known DNA intercalating chemotherapy drug that is widely used for treatment of different cancers. Its clinical utility is limited due to the observed genotoxic side effects on healthy cells suggesting that newer combination and genoprotective regimens are urgently needed for the management of doxorubicin chemotherapy. Some dietary phytochemicals are well known for their protective mechanism of action and genistein from soy is recognized as an anti-oxidant with similar properties. Therefore, the present study investigates the effect of genistein against the genotoxic doses of doxorubicin by assessing chromosomal aberrations, sister chromatid exchanges, cell cycle kinetics, cell viability, apoptosis, and DNA damage markers in cultured human lymphocytes. Our results reveal that genistein treatment significantly suppresses genotoxic damage induced by doxorubicin. It is concluded that genistein has the potential to reduce the genotoxicity induced by anti-cancer drugs, thereby reducing the chances of developing secondary tumors during the therapy. <iframe src="https://publications.waset.org/abstracts/3421.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20damage%20markers" title=" DNA damage markers"> DNA damage markers</a>, <a href="https://publications.waset.org/abstracts/search?q=doxorubicin" title=" doxorubicin"> doxorubicin</a>, <a href="https://publications.waset.org/abstracts/search?q=genistein" title=" genistein"> genistein</a>, <a href="https://publications.waset.org/abstracts/search?q=genotoxicity" title=" genotoxicity"> genotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20lymphocyte%20culture" title=" human lymphocyte culture"> human lymphocyte culture</a> </p> <a href="https://publications.waset.org/abstracts/3421/genistein-suppresses-doxorubicin-associated-genotoxicity-in-human-lymphocytes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3421.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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Genistein Suppresses Doxorubicin Associated Genotoxicity in Human Lymphocytes