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thalassemia major</title> <meta name="description" content="Search results for: beta thalassemia major"> <meta name="keywords" content="beta thalassemia major"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="beta thalassemia major"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 7872</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: beta thalassemia major</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7872</span> Prenatal Diagnosis of Beta Thalassemia Intermedia in Vietnamese Family: Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ha%20T.%20T.%20Ly">Ha T. T. Ly</a>, <a href="https://publications.waset.org/abstracts/search?q=Truc%20B.%20Truc"> Truc B. Truc</a>, <a href="https://publications.waset.org/abstracts/search?q=Hai%20N.%20Truong"> Hai N. Truong</a>, <a href="https://publications.waset.org/abstracts/search?q=Mai%20P.%20T.%20Nguyen"> Mai P. T. Nguyen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ngoc%20D.%20Ngo"> Ngoc D. Ngo</a>, <a href="https://publications.waset.org/abstracts/search?q=Khanh%20V.%20Tran"> Khanh V. Tran</a>, <a href="https://publications.waset.org/abstracts/search?q=Hai%20T.%20Le"> Hai T. Le</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Beta thalassemia is one of the most common inherited blood disorders, which is characterized by decreased or absent in beta globin expression. Patients with Beta thalassemia whose anemia is not so severe as to necessitate transfusions are said to have thalassemia intermedia. Objective: The goal of this study is prenatal diagnosis for pregnancy woman with Beta thalassemia intermedia and her husband with Beta thalassemia carrier at high risk of Beta thalassemia major in Northern of Vietnam. Material and method: The family has a 6 years-old compound heterozygous thalassemia major for CD71/72(+A) and Hbb:c. -78A>G/nt-28(A>G) male child. The father was heterozygous for CD71/72(+A) mutation which is Beta plus type and the mother was compound heterozygosity of two different variants, namely, Hbb: c. -78A>G/nt-28(A>G) and CD26(A-G) HbE. Prenatal Beta thalassemia mutation detection in fetal DNA was carried out using multiplex Amplification-refractory mutation system ARMS-PCR and confirmed by direct Sanger-sequencing Hbb gene. Prenatal diagnoses were perfomed by amniotic fluid sampling from pregnant woman in the 16-18th week of pregnancy after the genotypes of parents of the probands were identified. Result: When amniotic fluid sample was analyzed for Beta globin gene (Hbb), we found that the genotype is heterozygous for CD71/72(+A) and CD26(A-G) HbE. This genotype is different from the 1st child of this family. Conclusion: Prenatal diagnosis helps the parents to know the genotype and the thalassemia status of the fetus, so they can have early decision on their pregnancy. Genetic diagnosis provided a useful method in diagnosis for familial members in pedigree, genetic counseling and prenatal diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20thalassemia%20intermedia" title="beta thalassemia intermedia">beta thalassemia intermedia</a>, <a href="https://publications.waset.org/abstracts/search?q=Hbb%20gene" title=" Hbb gene"> Hbb gene</a>, <a href="https://publications.waset.org/abstracts/search?q=pedigree" title=" pedigree"> pedigree</a>, <a href="https://publications.waset.org/abstracts/search?q=prenatal%20diagnosis" title=" prenatal diagnosis"> prenatal diagnosis</a> </p> <a href="https://publications.waset.org/abstracts/59114/prenatal-diagnosis-of-beta-thalassemia-intermedia-in-vietnamese-family-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59114.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">383</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7871</span> Curcumin Promotes the Deoxygenated State of Hemoglobin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Roohallah%20Yousefi">Roohallah Yousefi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: In beta-thalassemia, an imbalance in the production of beta subunits of hemoglobin leads to the oxidation and deposition of excess alpha-globin chains at the cell membrane, resulting in the hemolysis of erythrocytes and a disorder of erythropoiesis. Antioxidants, such as curcumin, may promote this progression. This study aims to investigate the antioxidant effect of curcumin on hemolysate samples from patients with beta-thalassemia. Materials and methods: Pure curcumin was extracted and purified for use in studying its effect on the visual light absorbance of hemoglobin in hemolysate samples from beta-thalassemia patients compared to control samples. Changes in light absorbance at 540 and 700 nm wavelengths during exposure to curcumin were analyzed to examine the shift from oxyhemoglobin to deoxyhemoglobin. Results: Curcumin was found to dissolve rapidly and to a high degree in ethanol at 1 mg/ml, but did not dissolve in distilled water at the same concentration. The curcumin addition to the hemolysate sample of a patient with beta-thalassemia resulted in a decrease in the light absorbance of the sample at 540 nm wavelength, with minimal changes observed in the control sample. Conclusion: Curcumin deoxygenated the hemolysate samples from both the patient and control, causing hemoglobin precipitation to occur slowly. The study suggests a greater potential role for curcumin in deoxygenating hemoglobin in the hemolysate samples of beta-thalassemia patients compared to those of the normal control. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta-thalassemia" title="beta-thalassemia">beta-thalassemia</a>, <a href="https://publications.waset.org/abstracts/search?q=hemoglobin" title=" hemoglobin"> hemoglobin</a>, <a href="https://publications.waset.org/abstracts/search?q=curcumin" title=" curcumin"> curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=alpha-globin" title=" alpha-globin"> alpha-globin</a> </p> <a href="https://publications.waset.org/abstracts/189204/curcumin-promotes-the-deoxygenated-state-of-hemoglobin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189204.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">29</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7870</span> Depressive Trends in Children and Adolescents Suffering from Beta-Thalassemia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanober%20Khanum">Sanober Khanum</a>, <a href="https://publications.waset.org/abstracts/search?q=Barerah%20Siddiqui"> Barerah Siddiqui</a>, <a href="https://publications.waset.org/abstracts/search?q=Asim%20Qidwai"> Asim Qidwai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: To determine the risk factors and frequency of depressive trends in children and adolescents suffering from Beta-Thalassemia. Background: Thalassemia is a chronic disease affecting 10,000 people in 60 countries. Many studies show that prolonged medical conditions cause depression. Due to the invasive procedures and suffering, Beta-Thalassemia cause great psychological distress to both children and their caregivers. The study shows 14-24% prevalence of psychiatric problems in Thalassemic patients. Method: Sample consisted of 195 registered patients of A.M.T.F (Female=95 and Male=100). Based on age range the sample was divided into two groups, Group A = children (4-9 years) and Group B = adolescent (10-16 years). A detailed interview with a self-made screening measure was administered on parents to find out the level of depression in patients. Statistics: Chi-square and t-test was applied in order to analyze the data. Results show high prevalence of depression, depression n= 131(66.83%), no depression n=65(33.16%). Analyses reflect that age influences the level of depression Adolescent (71.05%) and Children (64.16%). The analysis also shows a difference in level of depression between both genders. (t=2.975, p < .05). Conclusion: There is a high possibility of developing depressive trend in children affected with Beta Thalassemia; especially females. Therefore, there is a dire need for psychological screening and appropriate treatment in order to improve physical; as well as mental health. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=childhood%20depression" title="childhood depression">childhood depression</a>, <a href="https://publications.waset.org/abstracts/search?q=chronic%20illness" title=" chronic illness"> chronic illness</a>, <a href="https://publications.waset.org/abstracts/search?q=psychopathology" title=" psychopathology"> psychopathology</a>, <a href="https://publications.waset.org/abstracts/search?q=Thalassemia" title=" Thalassemia"> Thalassemia</a> </p> <a href="https://publications.waset.org/abstracts/46231/depressive-trends-in-children-and-adolescents-suffering-from-beta-thalassemia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46231.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7869</span> Serum Interlukin-8 and Immunomodulation in Beta Thalassemia Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahira%20El%20Shafie">Shahira El Shafie</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanaa%20Eldash"> Hanaa Eldash</a>, <a href="https://publications.waset.org/abstracts/search?q=Engy%20Ghabbour"> Engy Ghabbour</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Eid"> Mohamed Eid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Several immunologic defects can be found in patients with beta-thalassemia, among which the impairment of neutrophil phagocytic function is of utmost importance. Attention has been directed to the role of proinflammatory cytokines in neutrophil chemotaxis and phagocytosis. Interleukin-8 (IL-8) is an important chemotactic and activation peptide for neutrophils; changes in IL-8 level and potential correlation with neutrophil function can be relevant to immunomodulation pathophysiology in beta-thalassemia patients. This case-control study aimed to evaluate IL-8 level and to assess granulocyte recruitment, as markers of immunomodulation, in poly-transfused thalassemia patients attending Fayoum University Hospitals. The study was conducted on 50 patients with ß thalassemia and 32 age-matched controls. 21/50 patients were transfused more than ten times, and 29/50 were transfused in a lower frequency. Patients and controls were subjected to thorough history taking and clinical examination, measurement of IL-8 level using human IL-8 ELISA kit, and Rebuck skin window technique (RSWT) to assess granulocyte recruitment. Our data showed statistically significant higher levels of IL-8 in ß thalassemia patients compared to control with a much higher difference in patients transfused more than ten times. Neutrophil recruitment was significantly lower in ß thalassemia patients compared to control at 4 hours and 24 hours test time. Although IL-8, the main chemotactic pro-inflammatory cytokine showed a higher level in thalassemia patients, neutrophils recruitment was significantly lower, especially in those receiving more than ten transfusion times. Our findings suggest a possible role of other neutrophil chemotactic factors, defective neutrophil response, or increased IL-8 as compensation of abnormal function. We recommend the use of IL-8 and Rebuck skin window technique as useful markers of immunomodulation in thalassemia and further study for these biomarkers to assess their clinical implications and impact on the management of thalassemia patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta-thalassemia" title="beta-thalassemia">beta-thalassemia</a>, <a href="https://publications.waset.org/abstracts/search?q=Interleukin-8" title=" Interleukin-8"> Interleukin-8</a>, <a href="https://publications.waset.org/abstracts/search?q=Rebuck%20skin%20window%20technique" title=" Rebuck skin window technique"> Rebuck skin window technique</a>, <a href="https://publications.waset.org/abstracts/search?q=immunomodulation" title=" immunomodulation"> immunomodulation</a> </p> <a href="https://publications.waset.org/abstracts/141613/serum-interlukin-8-and-immunomodulation-in-beta-thalassemia-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141613.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">187</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7868</span> Long-Term Cohort of Patients with Beta Thalassemia; Prevailing Role of Serum Ferritin Levels in Hypocalcemia and Growth Retardation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shervin%20Rashidinia">Shervin Rashidinia</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Shahmoradi"> Sara Shahmoradi</a>, <a href="https://publications.waset.org/abstracts/search?q=Seyyed%20Shahin%20Eftekhari"> Seyyed Shahin Eftekhari</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohsen%20Talebizadeh"> Mohsen Talebizadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Saleh%20Sadeghi"> Mohammad Saleh Sadeghi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Beta-thalassemia Major (BTM) is a kind of hereditary hemolytic anemia which depended on regular monthly blood transfusion. However, iron deposition into the organs leads to multi-organ damage. The present study is the first study which aimed to evaluate the average of five-years serum ferritin level and compared by the prevalence of short stature and hypocalcemia. Materials/Methods: A cross-sectional retrospective study which a total of 140 patients with beta-thalassemia who were referred to Qom Thalassemia Clinic between February 2011 and July 2016 were enrolled to be reviewed. The exclusion criteria were consisting of incomplete medical records, diagnosis less than 2-years-ago and the blood transfusion less than every 4 weeks. The data including age, gender, weight, height, age of initial blood transfusion, age of initial chelation therapy, ferritin, and calcium were collected and analysis by SPSS version 24. Results: A total of 140 patients were enrolled. Of them, 75 (53.4%) were female. The mean age of the patients was 13.4±4.6 years.The mean age of initial diagnosis was 20.2±7.4 months. Hypocalcemia and short stature were occurred in 41 (29.3%) and 37 (26.4%) patients, respectively. The mean five-years serum ferritin level was significantly higher in the patients with short stature and hypocalcemia (P<0.0001). However, rise in serum ferritin level significantly increases the risk of short-stature and hypocalcemia (1.0004- and 1.0029 fold, respectively). Conclusion: We demonstrated that prevalence of short stature and hypocalcemia were significantly higher in the BTM.However, ferritin significantly increases the risk of short stature and hypocalcemia. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta-thalassemia" title="beta-thalassemia">beta-thalassemia</a>, <a href="https://publications.waset.org/abstracts/search?q=ferritin" title=" ferritin"> ferritin</a>, <a href="https://publications.waset.org/abstracts/search?q=growth%20retardation" title=" growth retardation"> growth retardation</a>, <a href="https://publications.waset.org/abstracts/search?q=hypocalcemia" title=" hypocalcemia"> hypocalcemia</a> </p> <a href="https://publications.waset.org/abstracts/84464/long-term-cohort-of-patients-with-beta-thalassemia-prevailing-role-of-serum-ferritin-levels-in-hypocalcemia-and-growth-retardation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84464.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">328</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7867</span> Correlation of Serum Ferritin and Left Ventricular Function in Beta Thalassemia Major Patients with Increased Transfusion Dependence</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amna%20Imtiaz">Amna Imtiaz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aims: To correlate serum ferritin with left ventricular function in beta thalassemia major patients with increased transfusion dependence and to find out whether echocardiography can be used to assess pre clinical cardiac disease in these patients. Methods: The cross sectional study was conducted at Department of Pathology, Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan Institute of Medical Sciences, Islamabad. 60 patients of beta thalassemia major with increased transfusion dependence were enrolled in this study. Serum ferritin levels of all patients were measured by using indirect enzyme linked immunosorbent assay (ELISA). Echocardiography was performed on all patients by a consultant cardiologist by linking conventional echocardiography with tissue Doppler imaging. Ejection fraction and E/A ratio were measured in all patients to assess left ventricular systolic and diastolic function. Results: On the basis of serum ferritin level, patients were divided into three groups. Group I consisted of patients having serum ferritin level equal to or less than 2500 ng/ml. A total of 25 patients were placed in this group. Group II included patients having serum ferritin level between 2500 to 5000 ng/ml. A total of 22 patients were placed in this group. Group III included patients having serum ferritin level more than 5000 ng/ml. This group consisted of 13 patients. All patients having serum ferritin below 2500ng/ml had normal systolic function, and only 16% of the patients in this group had diastolic dysfunction as reflected by abnormal E/A ratio. In group II, 27% of the patients had systolic dysfunction reflected by subnormal ejection fraction while 40% of the patients had diastolic dysfunction. In group III, 62% of the patients had abnormal systolic and diastolic function. Pearson correlation was used to find a correlation between serum ferritin and left ventricular function. A strong negative correlation was found which is reflected by a p value of less than 0.05 which is significant. Chi square test is used to correlate serum ferritin with E/A ratio. P value came out to be less than 0.05 which is significant. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20thalassemia%20major" title="beta thalassemia major">beta thalassemia major</a>, <a href="https://publications.waset.org/abstracts/search?q=left%20ventricular%20function" title=" left ventricular function"> left ventricular function</a>, <a href="https://publications.waset.org/abstracts/search?q=serum%20ferritin" title=" serum ferritin"> serum ferritin</a>, <a href="https://publications.waset.org/abstracts/search?q=transfusion%20dependence" title=" transfusion dependence"> transfusion dependence</a> </p> <a href="https://publications.waset.org/abstracts/78904/correlation-of-serum-ferritin-and-left-ventricular-function-in-beta-thalassemia-major-patients-with-increased-transfusion-dependence" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78904.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7866</span> Cascade Screening for Beta-Thalassemia in Pakistan: Relatives’ Experiences of a Decision Support Intervention in Routine Practice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shenaz%20Ahmed">Shenaz Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Hussain%20Jafri"> Hussain Jafri</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammed%20Faran"> Muhammed Faran</a>, <a href="https://publications.waset.org/abstracts/search?q=Wajeeha%20Naseer%20Ahmed"> Wajeeha Naseer Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasmin%20Rashid"> Yasmin Rashid</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasmin%20Ehsan"> Yasmin Ehsan</a>, <a href="https://publications.waset.org/abstracts/search?q=Shabnam%20Bashir"> Shabnam Bashir</a>, <a href="https://publications.waset.org/abstracts/search?q=Mushtaq%20Ahmed"> Mushtaq Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Low uptake of cascade screening for βeta-Thalassaemia Major (β-TM) in the ‘Punjab Thalassaemia Prevention Project’ (PTPP) in Pakistan led to the development of a ‘decision support intervention for relatives’ (DeSIRe). This paper presents the experiences of relatives of children with β-TM of the DeSIRe following its use by PTPP field officers in routine clinical practice. Fifty-four semi-structured qualitative interviews were conducted (April to June 2021) with relatives in seven cities in the Punjab province (Lahore, Sheikhupura, Nankana Sahab, Kasur, Gujranwala, Multan, and Faisalabad). Thematic analysis shows that participants were satisfied with the content of the DeSIRe and its delivery by the field officers in a family meeting. They understood the main purpose of the DeSIRe was to improve their knowledge of β-TM and its inheritance, to enable them to make decisions about thalassemia carrier testing, particularly before marriage. While participants raised concerns about the stigma of testing positive, they believed the DeSIRe was an appropriate intervention, which supported relatives to make informed decisions. Our findings show the DeSIRe is appropriate for use by healthcare professionals in routine practice in a low-middle income country and has the potential to facilitate shared decision-making about cascade screening for thalassemia. Further research is needed to prove the efficacy of the DeSIRe. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thalassemia" title="thalassemia">thalassemia</a>, <a href="https://publications.waset.org/abstracts/search?q=Pakistan" title=" Pakistan"> Pakistan</a>, <a href="https://publications.waset.org/abstracts/search?q=cascade%20screening" title=" cascade screening"> cascade screening</a>, <a href="https://publications.waset.org/abstracts/search?q=decision%20support" title=" decision support"> decision support</a> </p> <a href="https://publications.waset.org/abstracts/141259/cascade-screening-for-beta-thalassemia-in-pakistan-relatives-experiences-of-a-decision-support-intervention-in-routine-practice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">240</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7865</span> Central Vascular Function and Relaxibility in Beta-thalassemia Major Patients vs. Sickle Cell Anemia Patients by Abdominal Aorta and Aortic Root Speckle Tracking Echocardiography</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gehan%20Hussein">Gehan Hussein</a>, <a href="https://publications.waset.org/abstracts/search?q=Hala%20Agha"> Hala Agha</a>, <a href="https://publications.waset.org/abstracts/search?q=Rasha%20Abdelraof"> Rasha Abdelraof</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20George"> Marina George</a>, <a href="https://publications.waset.org/abstracts/search?q=Antoine%20Fakhri"> Antoine Fakhri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: β-Thalassemia major (TM) and sickle cell disease (SCD) are inherited hemoglobin disorders resulting in chronic hemolytic anemia. Cardiovascular involvement is an important cause of morbidity and mortality in these groups of patients. The narrow border is between overt myocardial dysfunction and clinically silent left ventricular (LV) and / or right ventricular (RV) dysfunction in those patients. 3 D Speckle tracking echocardiography (3D STE) is a novel method for the detection of subclinical myocardial involvement. We aimed to study myocardial affection in SCD and TM using 3D STE, comparing it with conventional echocardiography, correlate it with serum ferritin level and lactate dehydrogenase (LDH). Methodology: Thirty SCD and thirty β TM patients, age range 4-18 years, were compared to 30 healthy age and sex matched control group. Cases were subjected to clinical examination, laboratory measurement of hemoglobin level, serum ferritin, and LDH. Transthoracic color Doppler echocardiography, 3D STE, tissue Doppler echocardiography, and aortic speckle tracking were performed. Results: significant reduction in global longitudinal strain (GLS), global circumferential strain (GCS), and global area strain (GAS) in SCD and TM than control (P value <0.001) there was significantly lower aortic speckle tracking in patients with TM and SCD than control (P value< 0.001). LDH was significantly higher in SCD than both TM and control and it correlated significantly positive mitral inflow E, (p value:0.022 and 0.072. r: 0.416 and -0.333 respectively) lateral E/E’ (p value.<0.001and 0.818. r. 0.618 and -0. 044.respectively) and septal E/E’ (p value 0.007 and 0.753& r value 0.485 and -0.060 respectively) in SCD but not TM and significant negative correlation between LDH and aortic root speckle tracking (value 0.681& r. -0.078.). The potential diagnostic accuracy of LDH in predicting vascular dysfunction as represented by aortic root GCS with a sensitivity 74% and aortic root GCS was predictive of LV dysfunction in SCD patients with sensitivity 100% Conclusion: 3D STE LV and RV systolic dysfunction in spite of their normal values by conventional echocardiography. SCD showed significantly lower right ventricular dysfunction and aortic root GCS than TM and control. LDH can be used to screen patients for cardiac dysfunction in SCD, not in TM <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thalassemia%20major" title="thalassemia major">thalassemia major</a>, <a href="https://publications.waset.org/abstracts/search?q=sickle%20cell%20disease" title=" sickle cell disease"> sickle cell disease</a>, <a href="https://publications.waset.org/abstracts/search?q=3d%20speckle%20tracking%20echocardiography" title=" 3d speckle tracking echocardiography"> 3d speckle tracking echocardiography</a>, <a href="https://publications.waset.org/abstracts/search?q=LDH" title=" LDH"> LDH</a> </p> <a href="https://publications.waset.org/abstracts/143367/central-vascular-function-and-relaxibility-in-beta-thalassemia-major-patients-vs-sickle-cell-anemia-patients-by-abdominal-aorta-and-aortic-root-speckle-tracking-echocardiography" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143367.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">170</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7864</span> Prevalence of Malocclusion and Assessment of Orthodontic Treatment Needs in Malay Transfusion-Dependent Thalassemia Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20H.%20Kosba">Mohamed H. Kosba</a>, <a href="https://publications.waset.org/abstracts/search?q=Heba%20A.%20Ibrahim"> Heba A. Ibrahim</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Rozita"> H. Rozita </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Statement of the Problem: The life expectancy for transfusion-dependent thalassemia patients has increased dramatically with iron-chelation therapy and other modern management modalities. In these patients, the most dominant maxillofacial manifestations are protrusion of zygomatic bones and premaxilla due to the hyperplasia of bone marrow. The purpose of this study is to determine the prevalence of malocclusion and orthodontic treatment needs according to the Dental Aesthetic Index (DAI) among Malay transfusion-dependent thalassemia patients. Orientation: This is a cross-sectional study consist of 43 Malay transfusion-dependent thalassemia patients, 22 males, and 19 females with the mean age of 15.9 years old (SD 3.58). The subjects were selected randomly from patients attending Paediatrics and Internal Medicine Clinic at Hospital USM and Hospital Sultana Bahiyah. The subjects were assessed for malocclusion according to Angle’s classification, and orthodontic treatment needs using DAI. The results show that 22 of the subjects (51.1%) have class II malocclusion, 12 subjects (28%) have class І, while 9 subjects (20.9%) have class Ⅲ. The assessment of orthodontic treatment needs to reveal 22 cases (51.1%) fall in the normal/minor needs category, 12 subjects (28%) fall in the severe and very severe category, while 9 subjects (20.9%) fall in the definite category. Conclusion & Significance: Half of Malay transfusion-dependent thalassemia patients have Class Ⅱmalocclusion. About 28% had malocclusion and required orthodontic treatment. This research shows that Malay transfusion-dependent thalassemia may require orthodontic management; earlier intervention to reduce the complexity of the treatment later, suggesting functional appliance as a suitable treatment option for them, a twin block appliance together with headgear to restrict maxillary growth suggested for management. The current protocol implemented by the Malaysian Ministry of Health for the management of these patients seems to be sufficient since the result shows that about 28% require orthodontic treatment need, according to DAI. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=prevalence" title="prevalence">prevalence</a>, <a href="https://publications.waset.org/abstracts/search?q=DAI" title=" DAI"> DAI</a>, <a href="https://publications.waset.org/abstracts/search?q=thalassaemia" title=" thalassaemia"> thalassaemia</a>, <a href="https://publications.waset.org/abstracts/search?q=angle%20classification" title=" angle classification"> angle classification</a> </p> <a href="https://publications.waset.org/abstracts/120778/prevalence-of-malocclusion-and-assessment-of-orthodontic-treatment-needs-in-malay-transfusion-dependent-thalassemia-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/120778.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">143</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7863</span> Ethical Discussions on Prenatal Diagnosis: Iranian Case of Thalassemia Prevention Program</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sachiko%20Hosoya">Sachiko Hosoya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: The purpose of this paper is to investigate the social policy of preventive genetic medicine in Iran, by following the legalization process of abortion law and the factors affecting the process in wider Iranian contexts. In this paper, ethical discussions of prenatal diagnosis and selective abortion in Iran will be presented, by exploring Iranian social policy to control genetic diseases, especially a genetic hemoglobin disorder called Thalassemia. The ethical dilemmas in application of genetic medicine into social policy will be focused. Method: In order to examine the role of the policy for prevention of genetic diseases and selective abortion in Iran, various resources have been sutudied, not only academic articles, but also discussion in the Parliament and documents related to a court case, as well as ethnographic data on living situation of Thalassemia patients. Results: Firstly, the discussion on prenatal diagnosis and selective abortion is overviewed from the viewpoints of ethics, disability rights activists, and public policy for lower-resources countries. As a result, it should be noted that the point more important in the discussion on prenatal diagnosis and selective abortion in Iran is the allocation of medical resources. Secondly, the process of implementation of national thalassemia screening program and legalization of ‘Therapeutic Abortion Law’ is analyzed, through scrutinizing documents such as the Majlis record, government documents and related laws and regulations. Although some western academics accuse that Iranian policy of selective abortion seems to be akin to eugenic public policy, Iranian government carefully avoid to distortions of the policy as ‘eugenic’. Thirdly, as a comparative example, discussions on an Iranian court case of patient’s ‘right not to be born’ will be introduced. Along with that, restrictive living environments of people with Thalassemia patients and the carriers are depicted, to understand some disabling social factors for people with genetic diseases in the local contexts of Iran. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=abortion" title="abortion">abortion</a>, <a href="https://publications.waset.org/abstracts/search?q=Iran" title=" Iran"> Iran</a>, <a href="https://publications.waset.org/abstracts/search?q=prenatal%20diagnosis" title=" prenatal diagnosis"> prenatal diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=public%20health%20ethics" title=" public health ethics"> public health ethics</a>, <a href="https://publications.waset.org/abstracts/search?q=Thalassemia%20prevention%20program" title=" Thalassemia prevention program"> Thalassemia prevention program</a> </p> <a href="https://publications.waset.org/abstracts/32290/ethical-discussions-on-prenatal-diagnosis-iranian-case-of-thalassemia-prevention-program" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">345</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7862</span> Wet Polymeric Precipitation Synthesis for Monophasic Tricalcium Phosphate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Grigoraviciute-Puroniene">I. Grigoraviciute-Puroniene</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Tsuru"> K. Tsuru</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Garskaite"> E. Garskaite</a>, <a href="https://publications.waset.org/abstracts/search?q=Z.%20Stankeviciute"> Z. Stankeviciute</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Beganskiene"> A. Beganskiene</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Ishikawa"> K. Ishikawa</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Kareiva"> A. Kareiva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tricalcium phosphate (β-Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>, β-TCP) powders were synthesized using wet polymeric precipitation method for the first time to our best knowledge. The results of X-ray diffraction analysis showed the formation of almost single a Ca-deficient hydroxyapatite (CDHA) phase of a poor crystallinity already at room temperature. With continuously increasing the calcination temperature up to 800 °C, the crystalline β-TCP was obtained as the main phase. It was demonstrated that infrared spectroscopy is very effective method to characterize the formation of β-TCP. The SEM results showed that β-TCP solids were homogeneous having a small particle size distribution. The β-TCP powders consisted of spherical particles varying in size from 100 to 300 nm. Fabricated β-TCP specimens were placed to the bones of the rats and maintained for 1-2 months. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tricalcium%20phosphate%20%28%CE%B2-Ca3%28PO4%292" title="Tricalcium phosphate (β-Ca3(PO4)2">Tricalcium phosphate (β-Ca3(PO4)2</a>, <a href="https://publications.waset.org/abstracts/search?q=bone%20regeneration" title=" bone regeneration"> bone regeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=wet%20chemical%20processing" title=" wet chemical processing"> wet chemical processing</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20precipitation" title=" polymeric precipitation"> polymeric precipitation</a> </p> <a href="https://publications.waset.org/abstracts/69402/wet-polymeric-precipitation-synthesis-for-monophasic-tricalcium-phosphate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69402.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7861</span> Synergistic Effect of Eugenol Acetate with Betalactam Antibiotic on Betalactamase and Its Bioinformatics Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vinod%20Nair">Vinod Nair</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Sadasivan"> C. Sadasivan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Beta-lactam antibiotics are the most frequently prescribed medications in modern medicine. The antibiotic resistance by the production of enzyme beta-lactamase is an important mechanism seen in microorganisms. Resistance to beta-lactams mediated by beta-lactamases can be overcome successfully with the use of beta-lactamase inhibitors. New generations of the antibiotics contain mostly synthetic compounds, and many side effects have been reported for them. Combinations of beta-lactam and beta-lactamase inhibitors have become one of the most successful antimicrobial strategies in the current scenario of bacterial infections. Plant-based drugs are very cheap and having lesser adverse effect than synthetic compounds. The synergistic effect of eugenol acetate with beta-lactams restores the activity of beta-lactams, allowing their continued clinical use. It is reported here the enhanced inhibitory effect of phytochemical, eugenol acetate, isolated from the plant Syzygium aromaticum with beta-lactams on beta-lactamase. The compound was found to have synergistic effect with the antibiotic amoxicillin against antibiotic-resistant strain of S.aureus. The enzyme was purified from the organism and incubated with the compound. The assay showed that the compound could inhibit the enzymatic activity of beta-lactamase. Modeling and molecular docking studies indicated that the compound can fit into the active site of beta-lactamase and can mask the important residue for hydrolysis of beta-lactams. The synergistic effects of eugenol acetate with beta-lactam antibiotics may justify, the use of these plant compounds for the preparation of β-lactamase inhibitors against β-lactam resistant S.aureus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=betalactamase" title="betalactamase">betalactamase</a>, <a href="https://publications.waset.org/abstracts/search?q=eugenol%20acetate" title=" eugenol acetate"> eugenol acetate</a>, <a href="https://publications.waset.org/abstracts/search?q=synergistic%20effect" title=" synergistic effect"> synergistic effect</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling" title=" molecular modeling"> molecular modeling</a> </p> <a href="https://publications.waset.org/abstracts/59242/synergistic-effect-of-eugenol-acetate-with-betalactam-antibiotic-on-betalactamase-and-its-bioinformatics-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59242.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7860</span> β-Lactamase Inhibitory Effects of Anchusa azurea Extracts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Naoual%20Boussoualim">Naoual Boussoualim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hayat%20Trabsa"> Hayat Trabsa</a>, <a href="https://publications.waset.org/abstracts/search?q=Iman%20Krache"> Iman Krache</a>, <a href="https://publications.waset.org/abstracts/search?q=Lekhmici%20Arrar"> Lekhmici Arrar</a>, <a href="https://publications.waset.org/abstracts/search?q=Abderrahmane%20Baghiani"> Abderrahmane Baghiani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Resistance to antibiotics has emerged following their widespread use; the important mechanism of beta-lactam resistance in bacteria is the production of beta-lactamase. In order to find new bioactive beta-lactamase inhibitors, this study investigated the inhibition effect of the extracts of Anchusa azurea (AA) on a beta-lactamase from Bacillus cereus. The extracts exerted inhibitory effects on beta-lactamase in a dose-dependent manner, the results showed that the crude extract (BrE) and the ethyl acetate extract (AcE) of Anchusa azurea showed a very high inhibitory activity at a concentration of 10 mg, the percentage of inhibition was between 58% and 68%. Not all extracts were as potent as the original inhibitors such as clavulanic acid, the isolation and the structural elucidation of the active constituents in these extracts will provide useful means in the development of beta -lactamase inhibitors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anchusa%20azurea" title="Anchusa azurea">Anchusa azurea</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20product" title=" natural product"> natural product</a>, <a href="https://publications.waset.org/abstracts/search?q=resistance" title=" resistance"> resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=antibiotics" title=" antibiotics"> antibiotics</a>, <a href="https://publications.waset.org/abstracts/search?q=beta-lactamase" title=" beta-lactamase"> beta-lactamase</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibitors" title=" inhibitors"> inhibitors</a> </p> <a href="https://publications.waset.org/abstracts/41796/v-lactamase-inhibitory-effects-of-anchusa-azurea-extracts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41796.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">511</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7859</span> Design Manufacture and Testing of a Combined Alpha-Beta Double Piston Stirling Engine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Calvin%20Antony">A. Calvin Antony</a>, <a href="https://publications.waset.org/abstracts/search?q=Sakthi%20Kumar%20Arul%20Prakash"> Sakthi Kumar Arul Prakash</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20R.%20Sanal%20Kumar"> V. R. Sanal Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper a unique alpha-beta double piston 'stirling engine' is designed, manufactured and conducted laboratory test to ameliorate the efficiency of the stirling engine. The paper focuses on alpha and beta type engines, capturing their benefits and eradicating their short comings; along with the output observed from the flywheel. In this model alpha engine is kinematically with a piston cylinder arrangement which works quite like a beta engine. The piston of the new cylinder is so designed that it replicates a glued displacer and power piston as similar to that of beta engine. The bigger part of the piston is the power piston, which has a gap around it, while the smaller part of the piston is tightly fit in the cylinder and acts like the displacer piston. We observed that the alpha-beta double piston stirling engine produces 25% increase in power compare to a conventional alpha stirling engine. This working model is a pointer towards for the design and development of an alpha-beta double piston Stirling engine for industrial applications for producing electricity from the heat producing exhaust gases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alpha-beta%20double%20piston%20stirling%20engine" title="alpha-beta double piston stirling engine ">alpha-beta double piston stirling engine </a>, <a href="https://publications.waset.org/abstracts/search?q=alpha%20stirling%20engine" title=" alpha stirling engine "> alpha stirling engine </a>, <a href="https://publications.waset.org/abstracts/search?q=beta%20double%20piston%20stirling%20engine" title=" beta double piston stirling engine "> beta double piston stirling engine </a>, <a href="https://publications.waset.org/abstracts/search?q=electricity%20from%20stirling%20engine" title=" electricity from stirling engine"> electricity from stirling engine</a> </p> <a href="https://publications.waset.org/abstracts/35104/design-manufacture-and-testing-of-a-combined-alpha-beta-double-piston-stirling-engine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35104.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">533</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7858</span> Use of Beta Blockers in Patients with Reactive Airway Disease and Concomitant Hypertension or Ischemic Heart Disease </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bharti%20Chogtu%20Magazine">Bharti Chogtu Magazine</a>, <a href="https://publications.waset.org/abstracts/search?q=Dhanya%20Soodana%20Mohan"> Dhanya Soodana Mohan</a>, <a href="https://publications.waset.org/abstracts/search?q=Shruti%20Nair"> Shruti Nair</a>, <a href="https://publications.waset.org/abstracts/search?q=Tanwi%20Trushna"> Tanwi Trushna</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study was undertaken to analyse the cardiovascular drugs being prescribed in patients with concomitant reactive airway disease and hypertension or ischemic heart diseases (IHD). Also, the effect of beta-blockers on respiratory symptoms in these patients was recorded. Data was collected from medical records of patients with reactive airway disease and concomitant hypertension and IHD. It included demographic details of the patients, diagnosis, drugs prescribed and the patient outcome regarding the exacerbation of asthma symptoms with intake of beta blockers. Medical records of 250 patients were analysed.13% of patients were prescribed beta-blockers. 12% of hypertensive patients, 16.6% of IHD patients and 20% of patients with concomitant hypertension and IHD were prescribed beta blockers. Of the 33 (13%) patients who were on beta-blockers, only 3 patients had an exacerbation of bronchial asthma symptoms. Cardioselective beta-blockers under supervision appear to be safe in patients with reactive airway disease and concomitant hypertension and IHD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20blockers" title="beta blockers">beta blockers</a>, <a href="https://publications.waset.org/abstracts/search?q=hypertension" title=" hypertension"> hypertension</a>, <a href="https://publications.waset.org/abstracts/search?q=ischemic%20heart%20disease" title=" ischemic heart disease"> ischemic heart disease</a>, <a href="https://publications.waset.org/abstracts/search?q=asthma" title=" asthma"> asthma</a> </p> <a href="https://publications.waset.org/abstracts/1343/use-of-beta-blockers-in-patients-with-reactive-airway-disease-and-concomitant-hypertension-or-ischemic-heart-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1343.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">445</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7857</span> Effects of Sn and Al on Phase Stability and Mechanical Properties of Metastable Beta Ti Alloys</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yonosuke%20Murayama">Yonosuke Murayama</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We have developed and studied a metastable beta Ti alloy, which shows super-elasticity and low Young’s modulus according to the phase stability of its beta phase. The super-elasticity and low Young’s modulus are required in a wide range of applications in various industrial fields. For example, the metallic implant with low Young’s modulus and non-toxicity is desirable because the large difference of Young’s modulus between the human bone and the implant material may cause a stress-shielding phenomenon. We have investigated the role of Sn and Al in metastable beta Ti-Cr-Sn, Ti-Cr-Al, Ti-V-Sn, and Ti-V-Al alloys. The metastable beta Ti-Cr-Sn, Ti-Cr-Al, Ti-V-Sn, and Ti-V-Al alloys form during quenching from the beta field at high temperature. While Cr and V act as beta stabilizers, Sn and Al are considered as elements to suppress the athermal omega phase produced during quenching. The athermal omega phase degrades the properties of super-elasticity and Young’s modulus. Although Al and Sn as single elements are considered as an alpha stabilizer and neutral, respectively, Sn and Al acted also as beta stabilizers when added simultaneously with beta stabilized element of Cr or V in this experiment. The quenched microstructure of Ti-Cr-Sn, Ti-Cr-Al, Ti-V-Sn, and Ti-V-Al alloys shifts from martensitic structure to beta single-phase structure with increasing Cr or V. The Young’s modulus of Ti-Cr-Sn, Ti-Cr-Al, Ti-V-Sn, and Ti-V-Al alloys decreased and then increased with increasing Cr or V, each showing its own minimum value of Young's modulus respectively. The composition of the alloy with the minimum Young’s modulus is a near border composition where the quenched microstructure shifts from martensite to beta. The border composition of Ti-Cr-Sn and Ti-V-Sn alloys required only less amount of each beta stabilizer, Cr or V, than Ti-Cr-Al and Ti-V-Al alloys. This indicates that the effect of Sn as a beta stabilizer is stronger than Al. Sn and Al influenced the competitive relation between stress-induced martensitic transformation and slip deformation. Thus, super-elastic properties of metastable beta Ti-Cr-Sn, Ti-Cr-Al, Ti-V-Sn, and Ti-V-Al alloys varied depending on the alloyed element, Sn or Al. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=metastable%20beta%20Ti%20alloy" title="metastable beta Ti alloy">metastable beta Ti alloy</a>, <a href="https://publications.waset.org/abstracts/search?q=super-elasticity" title=" super-elasticity"> super-elasticity</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20Young%E2%80%99s%20modulus" title=" low Young’s modulus"> low Young’s modulus</a>, <a href="https://publications.waset.org/abstracts/search?q=stress-induced%20martensitic%20transformation" title=" stress-induced martensitic transformation"> stress-induced martensitic transformation</a>, <a href="https://publications.waset.org/abstracts/search?q=beta%20stabilized%20element" title=" beta stabilized element"> beta stabilized element</a> </p> <a href="https://publications.waset.org/abstracts/123727/effects-of-sn-and-al-on-phase-stability-and-mechanical-properties-of-metastable-beta-ti-alloys" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/123727.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">146</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7856</span> Safety and Efficacy of RM-001, Autologous HBG1/2 Promoter-Modified CD34+Hematopoietic Stem and Progenitor Cells, in Transfusion-Dependent β-Thalassemia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rongrong%20Liu">Rongrong Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Li%20Wang"> Li Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Hui%20Xu"> Hui Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianpei%20Fang"> Jianpei Fang</a>, <a href="https://publications.waset.org/abstracts/search?q=Sixi%20Liu"> Sixi Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiaolin%20Yin"> Xiaolin Yin</a>, <a href="https://publications.waset.org/abstracts/search?q=Junbin%20Liang"> Junbin Liang</a>, <a href="https://publications.waset.org/abstracts/search?q=Gaohui%20Yan"> Gaohui Yan</a>, <a href="https://publications.waset.org/abstracts/search?q=Yaoyun%20Li"> Yaoyun Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yali%20Zhou"> Yali Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Xinyu%20Li"> Xinyu Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yue%20Li"> Yue Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Lei%20Shi"> Lei Shi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yongrong%20Lai"> Yongrong Lai</a>, <a href="https://publications.waset.org/abstracts/search?q=Junjiu%20Huang"> Junjiu Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Xinhua%20Zhang"> Xinhua Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Beta-Thalassemia is caused by reduced (β+) or absent (β0) synthesis of the β-globin chains of hemoglobin. Transfusions and oral iron chelation therapy have improved the quality of life for patients with Transfusion-Dependent thalassemia (TDT). Recent advances in genome editing platforms of CRISPR-Cas9 have paved the way for induction of HbF by reactivating expression of γ-chain.Aims: We performed CRISPR-Cas9-mediated genome editing of hematopoietic stem cells to mutate HBG1/HBG2 promoter sequence, thereby representing a naturally occurring HPFH-liked mutation, producing RM-001. Here, we present an initial assessment of safety and efficacy of RM-001 in patients with TDT. Methods: Patients (6–35 y of age) with TDT receiving packed red blood cell (pRBC) transfusions of ≥100 mL/kg/y or ≥10 units/y in the previous 2 y were eligible. CD34+ cells were edited with CRISPR-Cas9 using a guide RNA specific for the binding site of BCL11A on the HBG1/2 promoter. Prior to RM-001 product infusion (day 0), patients received myeloablative conditioning with Busulfan from day-7 to day-4. Patients were monitored for AEs Hb expression.Results: Data cut as of 28 Feb 2024, 16 TDT patients have been treated with RM-001 and followed ≥3 months. 5 of these 16 patients had finished their 24 months follow up. Eleven patients have β0/β0 genotype and five patients have β0/β+ genotype. In addition to β-thalassemia, two patients had α- deletion with the genotype of --/αα. Efficacy:All patients received a single dose intravenous infusion of RM-001 cells. 5 of them had been followed 24 months or longer. All patients achieved transfusion-independent (TI, total Hb continued ≥ 9g/dL) (Figure1). Patients demonstrated sustained and clinically meaningful increases in HbF levels since 4 month post-RM-001 infusion (Figure.2). Total hemoglobin in all patients was stable at 10-12g/dL during the follow-up period. Safety:The adverse events observed after RM-001 infusion were consistent with those that are typical of Busulfan-based myeloablation. The allelic editing analysis at 6-month visit showed that the on-target allelic editing frequency in bone marrow cells was 73.44% (64.65% to 84.6%, n=13).Summary/Conclusion: This interim analysis, in which all the 19 patients age from 7.9 to 25yo met the success criteria for the trial with respect to transfusion independence, showed that autologous HBG1/2 promoter-modified CD34+ HSPCs gene therapy resulted in an adequate amount of HbF as early as 2 months after infusion led to near-normal hemoglobin levels, remained transfusion-free through the reported period without product related SAE. After RM-001 infusion, high levels of HbF proportion and on-target editing in bone marrow cells were maintained. Submitted on behalf of the RM-001 Investigators. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thalassemian" title="thalassemian">thalassemian</a>, <a href="https://publications.waset.org/abstracts/search?q=genetherapy" title=" genetherapy"> genetherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=CRISPR%2FCas9" title=" CRISPR/Cas9"> CRISPR/Cas9</a>, <a href="https://publications.waset.org/abstracts/search?q=HbF" title=" HbF"> HbF</a> </p> <a href="https://publications.waset.org/abstracts/184624/safety-and-efficacy-of-rm-001-autologous-hbg12-promoter-modified-cd34hematopoietic-stem-and-progenitor-cells-in-transfusion-dependent-v-thalassemia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184624.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">19</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7855</span> Molecular Dynamics Simulation of Beta-Glucosidase of Streptomyces</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adam%20Abate">Adam Abate</a>, <a href="https://publications.waset.org/abstracts/search?q=Elham%20Rasti"> Elham Rasti</a>, <a href="https://publications.waset.org/abstracts/search?q=Philip%20Romero"> Philip Romero </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Beta-glucosidase is the key enzyme component present in cellulase and completes the final step during cellulose hydrolysis by converting the cellobiose to glucose. The regulatory properties of beta-glucosidases are most commonly found for the retaining and inverting enzymes. Hydrolysis of a glycoside typically occurs with general acid and general base assistance from two amino acid side chains, normally glutamic or aspartic acids. In order to obtain more detailed information on the dynamic events origination from the interaction with enzyme active site, we carried out molecular dynamics simulations of beta-glycosidase in protonated state (Glu-H178) and deprotonated state (Glu178). The theoretical models generated from our molecular dynamics simulations complement and advance the structural information currently available, leading to a more detailed understanding of Beta-glycosidase structure and function. This article presents the important role of Asn307 in enzyme activity of beta-glucosidase <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Beta-glucosidase" title="Beta-glucosidase">Beta-glucosidase</a>, <a href="https://publications.waset.org/abstracts/search?q=GROMACS" title=" GROMACS"> GROMACS</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulation" title=" molecular dynamics simulation"> molecular dynamics simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=structural%20parameters" title=" structural parameters "> structural parameters </a> </p> <a href="https://publications.waset.org/abstracts/31578/molecular-dynamics-simulation-of-beta-glucosidase-of-streptomyces" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31578.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">398</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7854</span> Smart Beta Portfolio Optimization</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saud%20Al%20Mahdi">Saud Al Mahdi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Traditionally,portfolio managers have been discouraged from timing the market. This means, for example, that equity managers have been forced to adhere strictly to a benchmark with static or relatively stable components, such as the SP 500 or the Russell 3000. This means that the portfolio’s exposures to all risk factors should mimic as closely as possible the corresponding exposures of the benchmark. The main risk factor, of course, is the market itself. Effectively, a long-only portfolio would be constrained to have a beta 1. More recently, however, managers have been given greater discretion to adjust their portfolio’s risk exposures (in particular, the beta of their portfolio) dynamically to match the manager’s beliefs about future performance of the risk factors themselves. This freedom translates into the manager’s ability to adjust the portfolio’s beta dynamically. These strategies have come to be known as smart beta strategies. Adjusting beta dynamically amounts to attempting to "time" the market; that is, to increase exposure when one anticipates that the market will rise, and to decrease it when one anticipates that the market will fall. Traditionally, market timing has been believed to be impossible to perform effectively and consistently. Moreover, if a majority of market participants do it, their combined actions could destabilize the market. The aim of this project is to investigate so-called smart beta strategies to determine if they really can add value, or if they are merely marketing gimmicks used to sell dubious investment strategies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta" title="beta">beta</a>, <a href="https://publications.waset.org/abstracts/search?q=alpha" title=" alpha"> alpha</a>, <a href="https://publications.waset.org/abstracts/search?q=active%20portfolio%20management" title=" active portfolio management"> active portfolio management</a>, <a href="https://publications.waset.org/abstracts/search?q=trading%20strategies" title=" trading strategies "> trading strategies </a> </p> <a href="https://publications.waset.org/abstracts/28119/smart-beta-portfolio-optimization" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28119.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">355</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7853</span> Homology Modelling of Beta Defensin 3 of Bos taurus and Its Docking Studies with Molecules Responsible for Formation of Biofilm</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ravinder%20Singh">Ravinder Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ankita%20Gurao"> Ankita Gurao</a>, <a href="https://publications.waset.org/abstracts/search?q=Saroj%20Bandhan"> Saroj Bandhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sudhir%20Kumar%20Kashyap"> Sudhir Kumar Kashyap </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Bos taurus Beta defensin 3 is a defensin peptide secreted by neutrophils and epithelial that exhibits anti-microbial activity. It is one of the crucial components forming an innate defense against intra mammary infections in livestock. The beta defensin 3 by virtue of its anti-microbial activity inhibits major mastitis pathogens including Staphylococcus aureus and Pseudomonas aeruginosa etc, which are also responsible for biofilm formation leading to antibiotic resistance phenomenon. Therefore, the defensin may prove as a non-conventional option to treat mastitis. In this study, computational analysis has been performed including sequence comparison among species and homology modeling of Bos taurus beta defensin 3 protein. The assessments of protein structure were done using the protein structure and model assessment tools integrated in Swiss Model server, which employs various local and global quality evaluation parameters. Further, molecular docking was also carried out between the defensin peptide and the components of biofilm to gain insight into various interactions and structural differences crucial for functionality of this protein. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20defensin%203" title="beta defensin 3">beta defensin 3</a>, <a href="https://publications.waset.org/abstracts/search?q=bos%20taurus" title=" bos taurus"> bos taurus</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modeling" title=" homology modeling"> homology modeling</a> </p> <a href="https://publications.waset.org/abstracts/64346/homology-modelling-of-beta-defensin-3-of-bos-taurus-and-its-docking-studies-with-molecules-responsible-for-formation-of-biofilm" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">291</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7852</span> Postpartum Depression and Its Association with Food Insecurity and Social Support among Women in Post-Conflict Northern Uganda</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kimton%20Opiyo">Kimton Opiyo</a>, <a href="https://publications.waset.org/abstracts/search?q=Elliot%20M.%20Berry"> Elliot M. Berry</a>, <a href="https://publications.waset.org/abstracts/search?q=Patil%20Karamchand"> Patil Karamchand</a>, <a href="https://publications.waset.org/abstracts/search?q=Barnabas%20K.%20Natamba"> Barnabas K. Natamba</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Postpartum depression (PPD) is a major psychiatric disorder that affects women soon after birth and in some cases, is a continuation of antenatal depression. Food insecurity (FI) and social support (SS) are known to be associated with major depressive disorder, and vice versa. This study was conducted to examine the interrelationships among FI, SS, and PPD among postpartum women in Gulu, a post-conflict region in Uganda. Methods: Cross-sectional data from postpartum women on depression symptoms, FI and SS were, respectively, obtained using the Center for Epidemiologic Studies-Depression (CES-D) scale, Individually Focused FI Access scale (IFIAS) and Duke-UNC functional social support scale. Standard regression methods were used to assess associations among FI, SS, and PPD. Results: A total of 239 women were studied, and 40% were found to have any PPD, i.e., with depressive symptom scores of ≥ 17. The mean ± standard deviation (SD) for FI score and SS scores were 6.47 ± 5.02 and 19.11 ± 4.23 respectively. In adjusted analyses, PPD symptoms were found to be positively associated with FI (unstandardized beta and standardized beta of 0.703 and 0.432 respectively, standard errors =0.093 and p-value < 0.0001) and negatively associated with SS (unstandardized beta and standardized beta of -0.263 and -0.135 respectively, standard errors = 0.111 and p-value = 0.019). Conclusions: Many women in this post-conflict region reported experiencing PPD. In addition, this data suggest that food security and psychosocial support interventions may help mitigate women’s experience of PPD or its severity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=postpartum%20depression" title="postpartum depression">postpartum depression</a>, <a href="https://publications.waset.org/abstracts/search?q=food%20insecurity" title=" food insecurity"> food insecurity</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20support" title=" social support"> social support</a>, <a href="https://publications.waset.org/abstracts/search?q=post-conflict%20region" title=" post-conflict region"> post-conflict region</a> </p> <a href="https://publications.waset.org/abstracts/99916/postpartum-depression-and-its-association-with-food-insecurity-and-social-support-among-women-in-post-conflict-northern-uganda" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99916.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">168</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7851</span> Investigating the Relationship between Growth, Beta and Liquidity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Amirhosseini">Zahra Amirhosseini</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahtab%20Nameni"> Mahtab Nameni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to investigate the relationship between growth, beta, and Company's cash. We calculate cash as dependent variable and growth opportunity and beta as independent variables. This study was based on an analysis of panel data. Population of the study is the companies which listed in Tehran Stock exchange and a financial data of 215 companies during the period 2010 to 2015 have been selected as the sample through systematic sampling. The results of the first hypothesis showed there is a significant relationship between growth opportunities cash holdings. Also according to the analysis done in the second hypothesis, we determined that there is an inverse relation between company risk and cash holdings. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=growth" title="growth">growth</a>, <a href="https://publications.waset.org/abstracts/search?q=beta" title=" beta"> beta</a>, <a href="https://publications.waset.org/abstracts/search?q=liquidity" title=" liquidity"> liquidity</a>, <a href="https://publications.waset.org/abstracts/search?q=company" title=" company"> company</a> </p> <a href="https://publications.waset.org/abstracts/55618/investigating-the-relationship-between-growth-beta-and-liquidity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55618.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7850</span> Prediction of All-Beta Protein Secondary Structure Using Garnier-Osguthorpe-Robson Method</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Tejasri">K. Tejasri</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Suvarna%20Vani"> K. Suvarna Vani</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Prathyusha"> S. Prathyusha</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Ramya"> S. Ramya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Proteins are chained sequences of amino acids which are brought together by the peptide bonds. Many varying formations of the chains are possible due to multiple combinations of amino acids and rotation in numerous positions along the chain. Protein structure prediction is one of the crucial goals worked towards by the members of bioinformatics and theoretical chemistry backgrounds. Among the four different structure levels in proteins, we emphasize mainly the secondary level structure. Generally, the secondary protein basically comprises alpha-helix and beta-sheets. Multi-class classification problem of data with disparity is truly a challenge to overcome and has to be addressed for the beta strands. Imbalanced data distribution constitutes a couple of the classes of data having very limited training samples collated with other classes. The secondary structure data is extracted from the protein primary sequence, and the beta-strands are predicted using suitable machine learning algorithms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=proteins" title="proteins">proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=secondary%20structure%20elements" title=" secondary structure elements"> secondary structure elements</a>, <a href="https://publications.waset.org/abstracts/search?q=beta-sheets" title=" beta-sheets"> beta-sheets</a>, <a href="https://publications.waset.org/abstracts/search?q=beta-strands" title=" beta-strands"> beta-strands</a>, <a href="https://publications.waset.org/abstracts/search?q=alpha-helices" title=" alpha-helices"> alpha-helices</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning%20algorithms" title=" machine learning algorithms"> machine learning algorithms</a> </p> <a href="https://publications.waset.org/abstracts/158938/prediction-of-all-beta-protein-secondary-structure-using-garnier-osguthorpe-robson-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158938.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7849</span> Role of Pro-Inflammatory and Regulatory Cytokines in Pathogenesis of Graves’ Disease in Association with Autoantibody Thyroid and Regulatory FoxP3 T-Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dwitya%20Elvira">Dwitya Elvira</a>, <a href="https://publications.waset.org/abstracts/search?q=Eryati%20Darwin"> Eryati Darwin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Graves’ disease (GD) is an autoimmune thyroid disease. Imbalance of Th1/Th2 cells and T-regulatory (Treg)/Th17 cells was thought to play pivotal role in the pathogenesis of GD. Treg FoxP3 produced TGF-β to maintain regulatory function, and Th17 cells produced IL-17 as cytokines that were thought in mediating several autoimmune diseases. The aim of this study is to assess the role of IL-17 and TGF-β in the pathogenesis of GD and to investigate its correlation with Thyroid Stimulating Hormone Receptor Antibody (TRAb) and Treg FoxP3 expression. Method: 30 GD patients and 27 age and sex-matched controls were enrolled in this study. Diagnosis of GD was based on clinical and biochemical of GD. Serum IL-17, TGF-β, TRAb, and FoxP3 were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed by using SPSS 21.0 (SPSS Inc.). Spearman rank correlation test was used for assessment of correlation. The statistical significance was accepted as P<0.05. Result: There was no significant correlation between IL-17 and TGF-β serum with expression of FoxP3 level in GD, but there was significant correlation between TGF-β and TRAb serum level (P<0.05). Serum levels of IL-17 and TGF-β were found to be elevated in patient group compared to control, where mean values of IL-17 were 14.43±2.15 pg/mL and TGF-β were 10.44±3.19 pg/mL in patients group; and in control group, level of IL-17 were 7.1±1.45 pg/mL and TGF-β were 4.95±1.35 pg/mL. Conclusion: Serum Il-17 and TGF-β were elevated in GD patients that reflect the role of inflammatory and regulatory cytokines activation in pathogenesis of GD. There was significant correlation between TGF-β and TRAb, revealing that Treg cytokines may play a role in pathogenesis of GD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=IL-17" title="IL-17">IL-17</a>, <a href="https://publications.waset.org/abstracts/search?q=TGF-B" title=" TGF-B"> TGF-B</a>, <a href="https://publications.waset.org/abstracts/search?q=FoxP3" title=" FoxP3"> FoxP3</a>, <a href="https://publications.waset.org/abstracts/search?q=TRAb" title=" TRAb"> TRAb</a>, <a href="https://publications.waset.org/abstracts/search?q=Graves%E2%80%99%20disease" title=" Graves’ disease"> Graves’ disease</a> </p> <a href="https://publications.waset.org/abstracts/56187/role-of-pro-inflammatory-and-regulatory-cytokines-in-pathogenesis-of-graves-disease-in-association-with-autoantibody-thyroid-and-regulatory-foxp3-t-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56187.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">286</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7848</span> Study on Beta-Ray Detection System in Water Using a MCNP Simulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ki%20Hyun%20Park">Ki Hyun Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Hye%20Min%20Park"> Hye Min Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeong%20Ho%20Kim"> Jeong Ho Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Chan%20Jong%20Park"> Chan Jong Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Koan%20Sik%20Joo"> Koan Sik Joo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the modern days, the use of radioactive substances is on the rise in the areas like chemical weaponry, industrial usage, and power plants. Although there are various technologies available to detect and monitor radioactive substances in the air, the technologies to detect underwater radioactive substances are scarce. In this study, computer simulation of the underwater detection system measuring beta-ray, a radioactive substance, has been done through MCNP. CaF₂, YAP(Ce) and YAG(Ce) have been used in the computer simulation to detect beta-ray as scintillator. Also, the source used in the computer simulation is Sr-90 and Y-90, both of them emitting only pure beta-ray. The distance between the source and the detector was shifted from 1mm to 10mm by 1 mm in the computer simulation. The result indicated that Sr-90 was impossible to measure below 1 mm since its emission energy is low while Y-90 was able to be measured up to 10mm underwater. In addition, the detector designed with CaF₂ had the highest efficiency among 3 scintillators used in the computer simulation. Since it was possible to verify the detectable range and the detection efficiency according to modeling through MCNP simulation, it is expected that such result will reduce the time and cost in building the actual beta-ray detector and evaluating its performances, thereby contributing the research and development. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Beta-ray" title="Beta-ray">Beta-ray</a>, <a href="https://publications.waset.org/abstracts/search?q=CaF%E2%82%82" title=" CaF₂"> CaF₂</a>, <a href="https://publications.waset.org/abstracts/search?q=detector" title=" detector"> detector</a>, <a href="https://publications.waset.org/abstracts/search?q=MCNP%20simulation" title=" MCNP simulation"> MCNP simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=scintillator" title=" scintillator"> scintillator</a> </p> <a href="https://publications.waset.org/abstracts/53352/study-on-beta-ray-detection-system-in-water-using-a-mcnp-simulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">510</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7847</span> Beta Titanium Alloys: The Lowest Elastic Modulus for Biomedical Applications: A Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohsin%20Talib%20Mohammed">Mohsin Talib Mohammed</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahid%20A.%20Khan"> Zahid A. Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Arshad%20N.%20Siddiquee"> Arshad N. Siddiquee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biometallic materials are the most important materials for use in biomedical applications especially in manufacturing a variety of biological artificial replacements in a modern worlds, e.g. hip, knee or shoulder joints, due to their advanced characteristics. Titanium (Ti) and its alloys are used extensively in biomedical applications based on their high specific strength and excellent corrosion resistance. Beta-Ti alloys containing completely biocompatible elements are exceptionally prospective materials for manufacturing of bioimplants. They have superior mechanical, chemical and electrochemical properties for use as biomaterials. These biomaterials have the ability to introduce the most important property of biochemical compatibility which is low elastic modulus. This review examines current information on the recent developments in alloying elements leading to improvements of beta Ti alloys for use as biomaterials. Moreover, this paper focuses mainly on the evolution, evaluation and development of the modulus of elasticity as an effective factor on the performance of beta alloys. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20alloys" title="beta alloys">beta alloys</a>, <a href="https://publications.waset.org/abstracts/search?q=biomedical%20applications" title=" biomedical applications"> biomedical applications</a>, <a href="https://publications.waset.org/abstracts/search?q=titanium%20alloys" title=" titanium alloys"> titanium alloys</a>, <a href="https://publications.waset.org/abstracts/search?q=Young%27s%20modulus" title=" Young's modulus"> Young's modulus</a> </p> <a href="https://publications.waset.org/abstracts/6030/beta-titanium-alloys-the-lowest-elastic-modulus-for-biomedical-applications-a-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6030.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">325</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7846</span> Interaction Effects of Dietary Ginger, Zingiber Officinale, on Plasma Protein Fractions in Rainbow Trout, Oncorhynchus Mykiss</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Taheri%20Mirghaed">Ali Taheri Mirghaed</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Ahani"> Sara Ahani</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashkan%20Zargar"> Ashkan Zargar</a>, <a href="https://publications.waset.org/abstracts/search?q=Seyyed%20Morteza%20Hoseini"> Seyyed Morteza Hoseini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diseases are the major challenges in intensive aquaculture that cause significant annual losses. Antibiotic-therapy is a common way to control bacterial disease in fish, and oxytetracycline (OTC) is the only oral antibiotic in aquaculture approved FDA. OTC has been found to have negative effects on fish, such as oxidative stress and immune-suppression, thus, it is necessary to mitigate such effects. Medicinal herbs have various benefits on fish, including antioxidant, immunostimulant, and anti-microbial effects. Therefore, we hypothesized if dietary ginger meal (GM) interacts with dietary OTC by monitoring plasma protein fractions in rainbow trout. The study was conducted as a 2 × 2 factorial design, including diets containing 0 and 1% GM and 0 and 1.66 % OTC (corresponding to 100 mg/kg fish biomass per day). After ten days treating the fish (60 g individual weight) with these feeds, blood samples were taken from al treatments (n =3). Plasma was separated by centrifugation, and protein fractions were determined by electrophoresis. The results showed that OTC and GM had interaction effects on total protein (P<0.001), albumin (P<0.001), alpha-1 fraction (P=0.010), alpha-2 fraction (P=0.001), beta-2 fraction (P=0.014), and gamma fraction (P<0.001). Beta-1 fraction was significantly (P=0.030) affected by dietary GM. GM decreased plasma total protein, albumin, and beta-2 but increased beta-1 fraction. OTC significantly decreased total protein (P<0.001), albumin (P=0.001), alpha-2 fraction (P<0.001), beta-2 fraction (P=0.004), and gamma fraction (P<0.001) but had no significant effects on alpha-1 and beta-1 fractions. Dietary GM inhibited/suppressed the effects of dietary OTC on the plasma total protein and protein fractions. In conclusion, adding 1% GM to diet can mitigate the negative effects of dietary OTC on plasma proteins. Thus, GM may boost health of rainbow trout during the period of medication with OTC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ginger" title="ginger">ginger</a>, <a href="https://publications.waset.org/abstracts/search?q=plasma%20protein%20electrophoresis" title=" plasma protein electrophoresis"> plasma protein electrophoresis</a>, <a href="https://publications.waset.org/abstracts/search?q=dietary%20additive" title=" dietary additive"> dietary additive</a>, <a href="https://publications.waset.org/abstracts/search?q=rainbow%20trout" title=" rainbow trout"> rainbow trout</a> </p> <a href="https://publications.waset.org/abstracts/170310/interaction-effects-of-dietary-ginger-zingiber-officinale-on-plasma-protein-fractions-in-rainbow-trout-oncorhynchus-mykiss" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170310.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">90</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7845</span> Effects of Ophiocordyceps dipterigena BCC 2073 β-Glucan as a Prebiotic on the in vitro Growth of Probiotic and Pathogenic Bacteria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wai%20Prathumpai">Wai Prathumpai</a>, <a href="https://publications.waset.org/abstracts/search?q=Pranee%20Rachtawee"> Pranee Rachtawee</a>, <a href="https://publications.waset.org/abstracts/search?q=Sutamat%20Khajeeram"> Sutamat Khajeeram</a>, <a href="https://publications.waset.org/abstracts/search?q=Pariya%20Na%20Nakorn"> Pariya Na Nakorn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The  β-glucan produced by <em>Ophiocordyceps dipterigena</em> BCC 2073 is a (1, 3)-β-D-glucan with highly branching O-6-linkedside chains that is resistant to acid hydrolysis (by hydrochloric acid and porcine pancreatic alpha-amylase). This β-glucan can be utilized as a prebiotic due to its advantageous structural and biological properties. The effects of using this β-glucan as the sole carbon source for the <em>in vitro</em> growth of two probiotic bacteria (<em>L. acidophilus</em> BCC 13938 and <em>B. animalis</em> ATCC 25527) were investigated. Compared with the effect of using 1% glucose or fructo-oligosaccharide (FOS) as the sole carbon source, using 1% β-glucan for this purpose showed that this prebiotic supported and stimulated the growth of both types of probiotic bacteria and induced them to produce the highest levels of metabolites during their growth. The highest levels of lactic and acetic acid, 10.04 g·L<sup>-1</sup> and 2.82 g·L<sup>-1</sup>, respectively, were observed at 2 h of cultivation using glucose as the sole carbon source. Furthermore, the fermentation broth obtained using 1% β-glucan as the sole carbon source had greater antibacterial activity against selected pathogenic bacteria (<em>B. subtilis </em>TISTR 008, <em>E. coli </em>TISTR 780, and <em>S. typhimurium</em> TISTR 292) than did the broths prepared using glucose or FOS as the sole carbon source. The fermentation broth obtained by growing <em>L. acidophilus</em> BCC 13938 in the presence of β-glucan inhibited the growth of <em>B. subtilis </em>TISTR 008 by more than 70% and inhibited the growth of both <em>S. typhimurium</em> TISTR 292 and <em>E. coli </em>TISTR 780 by more than 90%. In conclusion, <em>O. dipterigena</em> BCC 2073 is a potential source of a β-glucan prebiotic that could be used for commercial production in the near future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta-glucan" title="beta-glucan">beta-glucan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ophiocordyceps%20dipterigena" title=" Ophiocordyceps dipterigena"> Ophiocordyceps dipterigena</a>, <a href="https://publications.waset.org/abstracts/search?q=prebiotic" title=" prebiotic"> prebiotic</a>, <a href="https://publications.waset.org/abstracts/search?q=probiotic" title=" probiotic"> probiotic</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a> </p> <a href="https://publications.waset.org/abstracts/93585/effects-of-ophiocordyceps-dipterigena-bcc-2073-v-glucan-as-a-prebiotic-on-the-in-vitro-growth-of-probiotic-and-pathogenic-bacteria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93585.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7844</span> Exposing Investor Sentiment In Stock Returns</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Qiang%20Bu">Qiang Bu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper compares the explanatory power of sentiment level and sentiment shock. The preliminary test results show that sentiment shock plays a more significant role in explaining stocks returns, including the raw return and abnormal return. We also find that sentiment shock beta has a higher statistical significance than sentiment beta. These finding sheds new light on the relationship between investor sentiment and stock returns. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sentiment%20level" title="sentiment level">sentiment level</a>, <a href="https://publications.waset.org/abstracts/search?q=sentiment%20shock" title=" sentiment shock"> sentiment shock</a>, <a href="https://publications.waset.org/abstracts/search?q=explanatory%20power" title=" explanatory power"> explanatory power</a>, <a href="https://publications.waset.org/abstracts/search?q=abnormal%20stock%20return" title=" abnormal stock return"> abnormal stock return</a>, <a href="https://publications.waset.org/abstracts/search?q=beta" title=" beta"> beta</a> </p> <a href="https://publications.waset.org/abstracts/146061/exposing-investor-sentiment-in-stock-returns" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146061.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">137</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7843</span> Derivation of Neutrino Mass Parameters from the Study of Neutrinoless Double Beta Decay</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sabin%20Stoica">Sabin Stoica</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper the theoretical challenges in the study of neutrinoless double beta decay are reviewed. Then, new upper limits of the neutrino mass parameters in the case of three isotopes are derived; 48Ca, 76Ge, and 82Se, assuming two possible mechanisms of occurrence of this nuclear process, namely the exchange of i) light left-handed neutrinos and ii) heavy right-handed neutrinos, between two nucleons inside the nucleus. The derivation is based on accurate calculations of the phase space factors and nuclear matrix elements performed with new high-performance computer codes, which are described in more detail in recent publications. These results are useful both for a better understanding of the scale of neutrino absolute mass and for the planning of future double beta decay experiments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=double%20beta%20decay" title="double beta decay">double beta decay</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrino%20properties" title=" neutrino properties"> neutrino properties</a>, <a href="https://publications.waset.org/abstracts/search?q=nuclear%20matrix%20elements" title=" nuclear matrix elements"> nuclear matrix elements</a>, <a href="https://publications.waset.org/abstracts/search?q=phase%20space%20factors" title=" phase space factors "> phase space factors </a> </p> <a href="https://publications.waset.org/abstracts/22330/derivation-of-neutrino-mass-parameters-from-the-study-of-neutrinoless-double-beta-decay" class="btn btn-primary btn-sm">Procedia</a> <a 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