CINXE.COM
KEGG ORTHOLOGY: K17719
<!doctype html> <html><head> <title>KEGG ORTHOLOGY: K17719</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1743896238"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1743896238"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1743896238" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } else{ obj.style.display = 'none'; clk.innerHTML = ' » '+show; } } } function toggleData(bobj,e){ var id = bobj.id.replace(/[^0-9]/g,''); var dt = document.getElementById('kcfd'+id); e.preventDefault(); if(!dt.style.display||dt.style.display == 'none'){ document.getElementById('kcfb'+id).innerHTML = 'Hide'; dt.style.display = 'block'; } else{ document.getElementById('kcfb'+id).innerHTML = 'Show'; dt.style.display = 'none'; } } function btn(bobj,img) { bobj.src = "/Fig/bget/button_" + img + ".gif"; } function btn_e(e) { e = e || event; var obj = e.target; var img = e.target.src; var img_base = img.replace(/\\/g,'/').replace(/(b|bd|bh)\.gif$/,''); if(e.type == 'mousedown'||e.type == 'touchstart'){ obj.src = img_base +'bd.gif'; } else if(e.type == 'mouseover'){ obj.src = img_base +'bh.gif'; } else if(e.type == 'mouseup'||e.type == 'touchend'){ obj.src = img_base +'b.gif'; } else if(e.type == 'mouseout'){ obj.src = img_base +'b.gif'; } } function init(){ for(var i=1;i<=1;i++){ if(document.getElementById('kcfb'+i)){ document.getElementById('kcfb'+i).onclick = function(e){toggleData(this,e);}; } } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="650"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg4.gif"></a></td><td> </td><td><a name="orthology:K17719"></a><font class="title4">ORTHOLOGY: K17719</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_ko.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/kegg-bin/search_htext" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr4 w1"> <table width="650" class="w2"> <tr><th class="th40 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td40 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">K17719 KO <br> </span></code></td></tr></table></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Symbol</span></th> <td class="td41 defd"><div class="cel">CYP2C9<br> </div></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td40 defd"><div class="cel"><div class="cel">cytochrome P450 family 2 subfamily C9 [EC:<a href="/entry/1.14.14.51">1.14.14.51</a> <a href="/entry/1.14.14.52">1.14.14.52</a> <a href="/entry/1.14.14.53">1.14.14.53</a> 1.14.14.-]<br> </div></div></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td41 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00590+K17719">map00590</a> </span></td><td>Arachidonic acid metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00591+K17719">map00591</a> </span></td><td>Linoleic acid metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00830+K17719">map00830</a> </span></td><td>Retinol metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00980+K17719">map00980</a> </span></td><td>Metabolism of xenobiotics by cytochrome P450</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00982+K17719">map00982</a> </span></td><td>Drug metabolism - cytochrome P450</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01100+K17719">map01100</a> </span></td><td>Metabolic pathways</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map04726+K17719">map04726</a> </span></td><td>Serotonergic synapse</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map05204+K17719">map05204</a> </span></td><td>Chemical carcinogenesis - DNA adducts</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map05417+K17719">map05417</a> </span></td><td>Lipid and atherosclerosis</td></tr></table></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Reaction</span></th> <td class="td40 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07048">R07048</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07050">R07050</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07051">R07051</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07055">R07055</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07056">R07056</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07079">R07079</a> </span></td><td>benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07080">R07080</a> </span></td><td>benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07081">R07081</a> </span></td><td>benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07085">R07085</a> </span></td><td>benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R07087">R07087</a> </span></td><td>9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08267">R08267</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08275">R08275</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08285">R08285</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08324">R08324</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08325">R08325</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08326">R08326</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08390">R08390</a> </span></td><td></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/R08392">R08392</a> </span></td><td></td></tr></table></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Disease</span></th> <td class="td41 defd"><div class="cel"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/H01205">H01205</a> </span></td><td>Coumarin resistance</td></tr></table></div></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td40 defd"><div class="cel"><span class="nowrap">KEGG Orthology (KO) [BR:<a href="/brite/ko00001+K17719">ko00001</a>]<br> 09100 Metabolism<br> 09103 Lipid metabolism<br> 00590 Arachidonic acid metabolism<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 00591 Linoleic acid metabolism<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 09108 Metabolism of cofactors and vitamins<br> 00830 Retinol metabolism<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 09111 Xenobiotics biodegradation and metabolism<br> 00980 Metabolism of xenobiotics by cytochrome P450<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 00982 Drug metabolism - cytochrome P450<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 09150 Organismal Systems<br> 09156 Nervous system<br> 04726 Serotonergic synapse<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 09160 Human Diseases<br> 09161 Cancer: overview<br> 05204 Chemical carcinogenesis - DNA adducts<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 09166 Cardiovascular disease<br> 05417 Lipid and atherosclerosis<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 09180 Brite Hierarchies<br> 09181 Protein families: metabolism<br> 00199 Cytochrome P450<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> Enzymes [BR:<a href="/brite/ko01000+K17719">ko01000</a>]<br> 1. Oxidoreductases<br> 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen<br> 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor<br> 1.14.14.51 (S)-limonene 6-monooxygenase<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 1.14.14.52 (S)-limonene 7-monooxygenase<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> 1.14.14.53 (R)-limonene 6-monooxygenase<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> Cytochrome P450 [BR:<a href="/brite/ko00199+K17719">ko00199</a>]<br> Cytochrome P450, animal type<br> CYP2 family<br> K17719 CYP2C9; cytochrome P450 family 2 subfamily C9<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=K17719';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td41 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">GO: </span></td><td><a href="http://amigo.geneontology.org/amigo/term/GO:0018675">0018675</a> <a href="http://amigo.geneontology.org/amigo/term/GO:0018676">0018676</a> <a href="http://amigo.geneontology.org/amigo/term/GO:0052741">0052741</a></td></tr></table></td></tr> <tr><th class="th40 deft tal vtop"><span class="nowrap">Genes</span></th> <td class="td40 defd"><style>.g1{display:none;}</style><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">HSA: </span></td><td><a href="/entry/hsa:1559">1559</a>(CYP2C9)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PTR: </span></td><td><a href="/entry/ptr:100616515">100616515</a>(CYP2C9)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PPS: </span></td><td><a href="/entry/pps:100996034">100996034</a>(CYP2C9)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">GGO: </span></td><td><a href="/entry/ggo:101126456">101126456</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PON: </span></td><td><a href="/entry/pon:100450749">100450749</a>(CYP2C9)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PPYG: </span></td><td><a href="/entry/ppyg:129006530">129006530</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NLE: </span></td><td><a href="/entry/nle:100591471">100591471</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">HMH: </span></td><td><a href="/entry/hmh:116457268">116457268</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SSYN: </span></td><td><a href="/entry/ssyn:129468897">129468897</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">MCC: </span></td><td><a href="/entry/mcc:678686">678686</a>(CYP2C75) <a href="/entry/mcc:678695">678695</a>(CYP2C9)</td></tr></table><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">MCF: </span></td><td><a href="/entry/mcf:102115450">102115450</a>(CYP2C9) <a href="/entry/mcf:102147103">102147103</a>(CYP2C19)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">MTHB: </span></td><td><a href="/entry/mthb:126962028">126962028</a> <a href="/entry/mthb:126962032">126962032</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">MNI: </span></td><td><a href="/entry/mni:105479916">105479916</a> <a href="/entry/mni:105479949">105479949</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CSAB: </span></td><td><a href="/entry/csab:103216299">103216299</a>(CYP2C19) <a href="/entry/csab:103216301">103216301</a>(CYP2C9)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CATY: </span></td><td><a href="/entry/caty:105575618">105575618</a> <a href="/entry/caty:105581138">105581138</a> <a href="/entry/caty:105586929">105586929</a> <a href="/entry/caty:105586938">105586938</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PANU: </span></td><td><a href="/entry/panu:100997824">100997824</a> <a href="/entry/panu:101012978">101012978</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">TGE: </span></td><td><a href="/entry/tge:112631549">112631549</a> <a href="/entry/tge:112631550">112631550</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">MLEU: </span></td><td><a href="/entry/mleu:105534699">105534699</a> <a href="/entry/mleu:105534700">105534700</a> <a href="/entry/mleu:105535382">105535382</a> <a href="/entry/mleu:105536626">105536626</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">RRO: </span></td><td><a href="/entry/rro:104665355">104665355</a> <a href="/entry/rro:104666123">104666123</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">TFN: </span></td><td><a href="/entry/tfn:117083900">117083900</a> <a href="/entry/tfn:117092015">117092015</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PTEH: </span></td><td><a href="/entry/pteh:111531037">111531037</a> <a href="/entry/pteh:111552212">111552212</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CANG: </span></td><td><a href="/entry/cang:105501587">105501587</a> <a href="/entry/cang:105504516">105504516</a> <a href="/entry/cang:105504517">105504517</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">DORD: </span></td><td><a href="/entry/dord:106001520">106001520</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NCAR: </span></td><td><a href="/entry/ncar:124985776">124985776</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">SFUM: </span></td><td><a href="/entry/sfum:130029818">130029818</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">TVP: </span></td><td><a href="/entry/tvp:118828297">118828297</a> <a href="/entry/tvp:118828298">118828298</a> <a href="/entry/tvp:118828299">118828299</a> <a href="/entry/tvp:118828301">118828301</a> <a href="/entry/tvp:118828302">118828302</a></td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PBRV: </span></td><td><a href="/entry/pbrv:138168376">138168376</a> <a href="/entry/pbrv:138168698">138168698</a></td></tr></table></div><a href="javascript:void(0)" onclick="javascript:toggleField(this,"g1","show all","hide")"> » show all</a><br> <button class="btn" onclick="location.href='/kegg-bin/show_taxonomy?ko=K17719';return false;">Taxonomy</button><button class="btn" onclick="location.href='/kegg-bin/uniprot_list?ko=K17719';return false;">UniProt</button></td></tr> <tr><th class="th41 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td41 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/3196692">3196692</a></div></td></tr> <tr><th class="th40 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td40 repd"><div class="cel">Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP</div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td41 repd"><div class="cel">Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.</div></td></tr> <tr><th class="th40 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td40 repd"><div class="cel">Biochemistry 27:6929-40 (1988)<br>DOI:<a href="https://doi.org/10.1021/bi00418a039">10.1021/bi00418a039</a></div></td></tr> <tr><th class="th41 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td41 repd"><div class="cel">[hsa:<a href="/entry/hsa:1559">1559</a>]</div></td></tr> </table></td></tr></table> <br></td><td class="vtop"><div class="aw" style="margin-top:46px;"><div class="fm at th40"> All links </div> <div class="fm"><pre class="fm" style="margin-left:1em"> <span style="color:#006"><a href="/dbget-bin/get_linkdb?-t+1+ko:K17719">Ontology (3)</a></span> <a href="/dbget-bin/get_linkdb?-t+go+ko:K17719">GO (3)</a> <span style="color:#006"><a href="/dbget-bin/get_linkdb?-t+9+ko:K17719">Gene (2)</a></span> <a href="/dbget-bin/get_linkdb?-t+oc+ko:K17719">OC (2)</a> <a href="/dbget-bin/get_linkdb?-t+alldb+ko:K17719">All databases (5)</a> <br><a href="/dbget-bin/get_linkdb?-N+ko:K17719">Download RDF</a> </pre> </div></div> </td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>