Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies

<!DOCTYPE html> <html lang="it"> <head> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="shortcut icon" href="/sr/favicon.ico" /> <link href="/sr/jstree/themes/default/style.min.css" rel="stylesheet" type="text/css"><link rel="stylesheet" href="/sr/jquery-ui/jquery-ui.min.css"> <link rel="stylesheet" type="text/css" href="https://static.cineca.it/jd/npm/jgrowl@1.4.9/jquery.jgrowl.min.css" /> <link rel="stylesheet" href="https://static.cineca.it/jd/npm/select2@4.0.13/dist/css/select2.min.css" /> <link rel="stylesheet" href="https://static.cineca.it/jd/npm/select2-bootstrap-5-theme@1.1.1/dist/select2-bootstrap-5-theme.min.css" /> <link rel="stylesheet" href="/sr/cineca/css/bootstrap-ricerca.min.css"> <link rel="stylesheet" href="/sr/local.css"><title>Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies</title> <script src="https://static.cineca.it/jd/npm/jquery@3.7.1/dist/jquery.min.js" integrity="sha512-v2CJ7UaYy4JwqLDIrZUI/4hqeoQieOmAZNXBeQyjo21dadnwR+8ZaIJVT8EE2iyI61OV8e6M8PP2/4hpQINQ/g==" crossorigin="anonymous"></script> <script type="text/javascript" src="/sr/jquery-ui/jquery-ui.min.js"></script> <script type="text/javascript" src="/sr/jquery-ui-i18n/jquery.ui.datepicker-it.latest.js" charset="utf-8"></script> <script src="https://static.cineca.it/jd/npm/bootstrap@5.2.3/dist/js/bootstrap.bundle.min.js" integrity="sha384-kenU1KFdBIe4zVF0s0G1M5b4hcpxyD9F7jL+jjXkk+Q2h455rYXK/7HAuoJl+0I4" crossorigin="anonymous"></script> <script src="https://static.cineca.it/jd/npm/jgrowl@1.4.9/jquery.jgrowl.min.js"></script> <script src="https://static.cineca.it/jd/npm/select2@4.0.13/dist/js/select2.full.min.js"></script> <script src="https://static.cineca.it/jd/npm/blueimp-tmpl@3.20.0/js/tmpl.min.js"></script><script type="text/javascript" src="/sr/jstree/jstree.min.js"></script><script type="text/javascript" src="/sr/jquery/js/jquery.displaytag-ajax-1.2.js"></script> <script src="https://static.cineca.it/jd/npm/js-cookie@3.0.5/dist/js.cookie.min.js" integrity="sha256-WCzAhd2P6gRJF9Hv3oOOd+hFJi/QJbv+Azn4CGB8gfY=" crossorigin="anonymous" referrerpolicy="no-referrer"></script> <script> var JQ = $; var j = $; </script> <script type="text/javascript"> </script> <script type="text/javascript" src="/sr/cineca/js/cilea.js?fwkVersion=24.11.2.0"></script> <script type="text/javascript" src="/sr/cineca/js/fragment.js?fwkVersion=24.11.2.0"></script> <script type="text/javascript" src="/sr/cineca/js/treeview.js?fwkVersion=24.11.2.0"></script> <script type="text/javascript" src="/sr/cineca/js/ap-tool.js?fwkVersion=24.11.2.0"></script> <span style="display:none;" id="rememberToSaveText">Attenzione: i dati modificati non sono ancora stati salvati. Per confermare inserimenti o cancellazioni di voci è necessario confermare con il tasto SALVA/INSERISCI in fondo alla pagina</span> <script type="text/javascript" src="/sr/cineca/js/print.js?fwkVersion=24.11.2.0"></script> <script type="text/javascript" src="/sr/cineca/js/widget.js?fwkVersion=24.11.2.0"></script> <script type="text/javascript" src="/sr/cineca/js/layout.js?fwkVersion=24.11.2.0"></script> <script type="text/javascript"> var authenticatedPersonId=''; var authenticatedUser=false; </script> <script type="text/javascript" src="https://sfera.unife.it/static/js/utils.js"></script> <script type="text/javascript" src="https://sfera.unife.it/static/js/choice-support.js"></script> <script type="text/javascript"> j(document).ready(function() { j('body').on('change','#itemxpage', function() { var dspaceObjectId = $('#dspaceObjectId').val(); if (dspaceObjectId != null && dspaceObjectId != '') { $('#modal_display_item').modal('toggle'); showEventLog(dspaceObjectId, '1', this.value); } }); j('body').on('click',"#modal_display_item .pagination li:not('.active') .page-link", function(event) { var pagesize = $('#itemxpage').val(); var dspaceObjectId = $('#dspaceObjectId').val(); var url = new URL(this.href); var page = url.searchParams.get("page"); if (page == null || isNaN(page)){ page = 1; } if (dspaceObjectId != null && dspaceObjectId != '') { $('#modal_display_item').modal('toggle'); showEventLog(dspaceObjectId,page, pagesize); } return false; }); }); function showEventLog(dsoId, page, pagesize) { var url = "/dspaceObjectEventLog/widgetSearch.modal"; jQuery.ajax({ url: url, method: 'GET', data: {dspaceObjectId: dsoId, posting: 1, modalSize: 'xlarge', page: page, pageSize: pagesize}, success: function(data) { var $modal = $(data); $modal.attr('id','modal_display_item'); $('body').append($modal); var myModal = new bootstrap.Modal(document.getElementById('modal_display_item'), {backdrop: true}); myModal.show(); $modal.filter('.modal').on('hidden.bs.modal', function(){ $modal.remove(); }); } }); } </script> <script type"text/javascript"> $(document).ready(function() { checkMoreless(); }); function checkMoreless() { if($('.moreless-more').length) { var more = $('<a class="btn-link"></a>').html(' espandi'); more.click(function(){ var moretext = $(this).next('.moreless-more'); var lesstext = $(this).prev('.moreless-fixed'); lesstext.html(lesstext.html().substring(0, lesstext.html().length-3)); moretext.toggleClass('hide'); $(this).toggleClass('hide'); var less = $('<a class="btn-link"></a>').html(' comprimi'); less.click(function(){ var moretext = $(this).prev('.moreless-more'); moretext.toggleClass('hide'); $(this).toggleClass('hide'); moretext.prev('a').toggleClass('hide'); var elements = document.getElementsByTagName('span'); for (var i = 0; i < elements.length; i++) { if((elements[i].className).indexOf('moreless-fixed') > -1) { if(elements[i].innerHTML.indexOf('...') == -1){ elements[i].innerHTML=elements[i].innerHTML+'...'; } } } }); moretext.after(less); }); $('.moreless-more').before(more); $('.moreless-more').toggleClass('hide'); } } </script><script> window.customCookieJsonConfigPath='/sr/cookie-config.json'; </script> <script src="https://static.iu.cineca.it/v1/default.js"></script> <script type="text/javascript"> function isThirdPartyCookieEnabled() { var cookieString = Cookies.get('cc_cookie'); if (cookieString==null||cookieString=="") return false; var cookieJson = JSON.parse(cookieString); var retValue = false; $.each(cookieJson.level , function (key, value) { if(value == 'thirdParty') retValue = true; }); return retValue; } $(document).on('click', '.c-bn', function() { Cookies.set('thirdParty',isThirdPartyCookieEnabled(), { path: '/'}); }); Cookies.set('thirdParty',isThirdPartyCookieEnabled(), { path: '/' }); </script> <script type="text/javascript"> $(document).ready(function() { if (typeof trackEventCategoryDone === "undefined") { trackEvent('trackPageView'); } }); </script> <script type="text/javascript" src="/sr/local.js?fwkVersion=24.11.2.0"></script> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <meta name="DC.identifier" content="scopus" xml:lang="*" /> <meta name="DC.identifier" content="pubmed" xml:lang="*" /> <meta name="DC.identifier" content="crossref" xml:lang="*" /> <meta name="DC.date" content="2017-02-03T12:39:39Z" xml:lang="*" scheme="DCTERMS.W3CDTF" /> <meta name="DC.date" content="2016-09-12T12:44:20Z" xml:lang="*" scheme="DCTERMS.W3CDTF" /> <meta name="DC.type" content="03 Contributo in rivista (Pubblicazione in Rivista)::03.1 Articolo su rivista" xml:lang="it" /> <meta name="DC.description" content="partially_open" xml:lang="en" /> <meta name="DC.type" content="internazionale" xml:lang="en" /> <meta name="DC.description" content="14" /> <meta name="DC.identifier" content="27527584" xml:lang="en" /> <meta name="DC.type" content="Esperti anonimi" xml:lang="en" /> <meta name="DCTERMS.dateAccepted" content="2016-09-12T12:44:20Z" scheme="DCTERMS.W3CDTF" /> <meta name="DC.description" content="no" xml:lang="en" /> <meta name="DC.identifier" content="2-s2.0-84982095239" xml:lang="en" /> <meta name="DC.identifier" content="http://hdl.handle.net/11392/2352324" scheme="DCTERMS.URI" /> <meta name="DC.language" content="eng" xml:lang="en" scheme="DCTERMS.RFC1766" /> <meta name="DC.relation" content="3685" xml:lang="en" /> <meta name="DC.relation" content="25" xml:lang="en" /> <meta name="DC.identifier" content="https://link.springer.com/article/10.1007/s00213-016-4402-y" xml:lang="en" /> <meta name="DC.identifier" content="10.1007/s00213-016-4402-y" xml:lang="en" /> <meta name="DC.identifier" content="WOS:000385518500003" xml:lang="en" /> <meta name="DC.relation" content="21-22" xml:lang="en" /> <meta name="DCTERMS.issued" content="2016" xml:lang="en" scheme="DCTERMS.W3CDTF" /> <meta name="DC.relation" content="STAMPA" xml:lang="en" /> <meta name="DC.type" content="262" /> <meta name="DC.description" content="This research has been funded by the Drug Policies Department, Presidency of the Council of Ministers, Italy (project NSDrugs to M. Marti) and by local funds from the University of Ferrara to M. Marti" xml:lang="en" /> <meta name="DCTERMS.available" content="2016-09-12T12:44:20Z" scheme="DCTERMS.W3CDTF" /> <meta name="DC.contributor" content="ITA" xml:lang="en" /> <meta name="DC.title" content="Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies" xml:lang="en" /> <meta name="DC.relation" content="3709" xml:lang="en" /> <meta name="DC.relation" content="233" xml:lang="en" /> <meta name="DC.type" content="info:eu-repo/semantics/article" /> <meta name="DC.subject" content="Socio-culturale" xml:lang="en" /> <meta name="DC.description" content="Rationale: AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are marketed as incense, herbal preparations or chemical supply for their psychoactive Cannabis-like effects. Objectives: The present study was aimed at investigating the in vitro and in vivo pharmacological activity of AKB48 and 5F-AKB48 in male CD-1 mice and comparing their in vivo effects with those caused by the administration of Δ9-THC and JWH-018. Results: In vitro competition binding experiments performed on mouse and human CB1 and CB2 receptors revealed a nanomolar affinity and potency of the AKB48 and 5F-AKB48. In vivo studies showed that AKB48 and 5F-AKB48, induced hypothermia, increased pain threshold to both noxious mechanical and thermal stimuli, caused catalepsy, reduced motor activity, impaired sensorimotor responses (visual, acoustic and tactile), caused seizures, myoclonia, hyperreflexia and promoted aggressiveness in mice. Moreover, microdialysis study in freely moving mice showed that systemic administration of AKB48 and 5F-AKB48 stimulated dopamine release in the nucleus accumbens. Behavioural, neurological and neurochemical effects were fully prevented by the selective CB1 receptor antagonist/inverse agonist AM 251. Conclusions: For the first time, the present study demonstrates the overall pharmacological effects induced by the administration of AKB48 and 5F-AKB48 in mice and suggests that the fluorination can increase the power and/or effectiveness of SCBs. Furthermore, this study outlines the potential detrimental effects of SCBs on human health." /> <meta name="DC.relation" content="UNIFE - FAR 2016" xml:lang="en" /> <meta name="DC.subject" content="AKB48, 5F-AKB48, JWH-018, Δ9-THC, Sensorimotor responses, Cannabinoids, Synthetic cannabinoids, Behavior, Microdialysis" /> <meta name="DC.description" content="open" xml:lang="en" /> <meta name="DC.date" content="2016-08-15" scheme="DCTERMS.W3CDTF" /> <meta name="DC.contributor" content="Dipartimento di Medicina Traslazionale e per la Romagna" xml:lang="*" /> <meta name="DC.contributor" content="Dipartimento di Scienze chimiche, farmaceutiche ed agrarie" xml:lang="*" /> <meta name="DC.contributor" content="Dipartimento di Scienze della vita e biotecnologie" xml:lang="*" /> <meta name="DC.contributor" content="Dipartimento di Scienze dell’Ambiente e della Prevenzione" xml:lang="*" /> <meta name="DC.contributor" content="Universita' degli Studi di FERRARA" xml:lang="*" /> <meta name="DC.contributor" content="509" xml:lang="*" /> <meta name="DC.contributor" content="516" xml:lang="*" /> <meta name="DC.contributor" content="38098" xml:lang="*" /> <meta name="DC.contributor" content="38598" xml:lang="*" /> <meta name="DC.contributor" content="40739" xml:lang="*" /> <meta name="DC.subject" content="AKB48" xml:lang="*" /> <meta name="DC.subject" content="5F-AKB48" xml:lang="*" /> <meta name="DC.subject" content="JWH-018" xml:lang="*" /> <meta name="DC.subject" content="Δ9-THC" xml:lang="*" /> <meta name="DC.subject" content="Sensorimotor responses" xml:lang="*" /> <meta name="DC.subject" content="Cannabinoids" xml:lang="*" /> <meta name="DC.subject" content="Synthetic cannabinoids" xml:lang="*" /> <meta name="DC.subject" content="Behavior" xml:lang="*" /> <meta name="DC.subject" content="Microdialysis" xml:lang="*" /> <meta name="DC.date" content="2024/08/09 01:09:36" xml:lang="*" scheme="DCTERMS.W3CDTF" /> <meta name="DC.date" content="1723158576205" xml:lang="*" scheme="DCTERMS.W3CDTF" /> <meta name="DC.contributor" content="AREA MIN. 03 - Scienze chimiche" xml:lang="*" /> <meta name="DC.contributor" content="AREA MIN. 03 - Scienze chimiche" xml:lang="*" /> <meta name="DC.contributor" content="AREA MIN. 05 - Scienze biologiche" xml:lang="*" /> <meta name="DC.contributor" content="AREA MIN. 05 - Scienze biologiche" xml:lang="*" /> <meta name="DC.contributor" content="AREA MIN. 06 - Scienze mediche" xml:lang="*" /> <meta name="DC.description" content="Canazza, Isabella; Ossato, Andrea; Trapella, Claudio; Fantinati, Anna; de Luca, Maria Antonietta; Margiani, Giulia; Vincenzi, Fabrizio; Rimondo, Claudia; Di Rosa, Fabiana; Gregori, Adolfo; Varani, Katia; Borea, Pier Andrea; Serpelloni, Giovanni; Marti, Matteo" xml:lang="en" /> <meta name="DC.description" content="Canazza, Isabella; Ossato, Andrea; Trapella, Claudio; Fantinati, Anna; de Luca, Maria Antonietta; Margiani, Giulia; Vincenzi, Fabrizio; Rimondo, Claudia; Di Rosa, Fabiana; Gregori, Adolfo; Varani, Katia; Borea, Pier Andrea; Serpelloni, Giovanni; Marti, Matteo" /> <meta name="citation_title" content="Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies" /> <meta name="citation_author" content="Canazza, Isabella" /> <meta name="citation_author_email" content="cnzsll@unife.it" /> <meta name="citation_author" content="Ossato, Andrea" /> <meta name="citation_author_email" content="sstndr@unife.it" /> <meta name="citation_author" content="Trapella, Claudio" /> <meta name="citation_author_email" content="trpcld@unife.it" /> <meta name="citation_author_orcid" content="0000-0002-6666-143X" /> <meta name="citation_author" content="Fantinati, Anna" /> <meta name="citation_author_email" content="fntnna1@unife.it" /> <meta name="citation_author_orcid" content="0000-0003-0437-5670" /> <meta name="citation_author" content="de Luca, Maria Antonietta" /> <meta name="citation_author" content="Margiani, Giulia" /> <meta name="citation_author" content="Vincenzi, Fabrizio" /> <meta name="citation_author_email" content="vncfrz@unife.it" /> <meta name="citation_author_orcid" content="0000-0002-5027-1699" /> <meta name="citation_author" content="Rimondo, Claudia" /> <meta name="citation_author" content="Di Rosa, Fabiana" /> <meta name="citation_author" content="Gregori, Adolfo" /> <meta name="citation_author" content="Varani, Katia" /> <meta name="citation_author_email" content="vrk@unife.it" /> <meta name="citation_author_orcid" content="0000-0003-4562-1348" /> <meta name="citation_author" content="Borea, Pier Andrea" /> <meta name="citation_author_email" content="bpa@unife.it" /> <meta name="citation_author" content="Serpelloni, Giovanni" /> <meta name="citation_author" content="Marti, Matteo" /> <meta name="citation_author_email" content="mto@unife.it" /> <meta name="citation_author_orcid" content="0000-0001-8751-2882" /> <meta name="citation_date" content="2016" /> <meta name="citation_issn" content="0033-3158" /> <meta name="citation_journal_title" content="PSYCHOPHARMACOLOGY" /> <meta name="citation_volume" content="233" /> <meta name="citation_issue" content="21-22" /> <meta name="citation_firstpage" content="3685" /> <meta name="citation_lastpage" content="3709" /> <meta name="citation_doi" content="10.1007/s00213-016-4402-y" /> <meta name="citation_pmid" content="27527584" /> <meta name="citation_abstract_html_url" content="https://sfera.unife.it/handle/11392/2352324" /> <meta name="citation_pdf_url" content="https://sfera.unife.it/bitstream/11392/2352324/5/MARTI%2011392-2352324%20pre-print.pdf" /> <meta name="citation_language" content="eng" /> <meta name="citation_keywords" content="AKB48, 5F-AKB48, JWH-018, Δ9-THC, Sensorimotor responses, Cannabinoids, Synthetic cannabinoids, Behavior, Microdialysis" /> <script type="text/javascript"> $(document).on('click', '.c-bn', function() { location.reload(); }); </script> </head> <body class="body-default body-anonymous"> <header class="navbar navbar-expand-md navbar-dark sticky-top layout-top bg-primary iu-hide"> <nav class="container-fluid flex-wrap flex-md-nowrap" aria-label="menu top"> <a class="navbar-brand ps-0 pt-0 pb-0 pe-3" href="https://sfera.unife.it/" aria-label="link homepage" id="uiLogoLink"> <img src="/sr/logo_iris.png" alt="IRIS" id="uiLogoImg" class="d-block my-1 navbar-brand-img"/> </a> <a class="navbar-brand ps-3 pt-0 pb-0 pe-3 me-3" href="" aria-label="link homepage università" id="customerLogoLink"> <img src="/sr/logo_customer.png" alt="IRIS" id="clientLogoImg" class="d-block my-1 navbar-brand-img"/> </a> <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="mostra/nascondi menu"> <span class="fas fa-bars"></span> </button> <div class="collapse navbar-collapse" id="navbarSupportedContent"> <ul class="navbar-nav flex-row flex-wrap pt-2 py-md-0"> </ul> <ul class="navbar-nav flex-row flex-wrap ms-md-auto"> <li class="nav-item col-6 col-md-auto " id="topNavHome"> <a class="nav-link p-2" href="https://sfera.unife.it/">Home</a> </li> <li class="nav-item col-6 col-md-auto dropdown"> <a class="nav-link p-2 dropdown-toggle" href="#" id="navbarDropdownBrowse" role="button" data-bs-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Sfoglia</a> <div class="dropdown-menu" aria-labelledby="navbarDropdownBrowse"> <a class="dropdown-item" href="https://sfera.unife.it/community-list">Macrotipologie<br/>& tipologie</a> <div class="dropdown-divider"></div> <a class="dropdown-item" href="https://sfera.unife.it/browse?type=author">Autore</a> <a class="dropdown-item" href="https://sfera.unife.it/browse?type=title">Titolo</a> <a class="dropdown-item" href="https://sfera.unife.it/browse?type=relationJournal">Riviste</a> <a class="dropdown-item" href="https://sfera.unife.it/browse?type=relationSerie">Serie</a> </div> </li> </ul> <form class="navbar-search-top d-flex" action="https://sfera.unife.it/simple-search" method="get" role="search"> <div class="input-group p-2"> <input class="form-control bg-primary layout-top-input" type="search" placeholder="Search IRIS" name="query" id="tequery" size="25" aria-label="Search IRIS"> <button class="btn btn-primary layout-top-input-btn" type="submit"><span class="fas fa-search"></span></button> </div> </form> <ul class="navbar-nav flex-row flex-wrap"> <li class="nav-item col-6 col-md-auto dropdown"> <a class="nav-link p-2 dropdown-toggle" href="#" id="navbarDropdownLanguage" role="button" data-bs-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> IT</a> <div class="dropdown-menu dropdown-menu-end" aria-labelledby="navbarDropdownLanguage"> <a class="dropdown-item" href="javascript:reloadLanguageModuleAll('https://sfera.unife.it',['bi','rm','gw','ma','','saiku','ap'],'/language/change.json','it');" ><img src="/sr/cineca/images/flag/flag_it.png" alt="Italiano" title=""/> Italiano</a> <a class="dropdown-item" href="javascript:reloadLanguageModuleAll('https://sfera.unife.it',['bi','rm','gw','ma','','saiku','ap'],'/language/change.json','en');" ><img src="/sr/cineca/images/flag/flag_en.png" alt="English" title="English"/> English</a> </div> </li> <li class="nav-item col-6 col-md-auto "> <script type="text/javascript">  </script><noscript><a href="https://wiki.u-gov.it/confluence/x/HJEWAw" target="dspacepopup"><span class="fas fa-question-circle" title="Aiuto"></span></a></noscript> </li> <li class="nav-item col-6 col-md-auto dropdown"><a class="nav-link p-2" href="https://sfera.unife.it/securityLanding.htm">LOGIN</a></li> </ul> </div> </nav> </header> <div class="site-header iu-hide bg-secondary text-white"> <div class="site-title CinecaSiteIntroduction" id="headerText"> <div> <h1>SFERA <small>Archivio dei prodotti della Ricerca dell'Università di Ferrara</small></h1></div> </div> </div> <div class="container-xxl ps-0 pe-0 layout-no-sidebar" id="mainContainerDiv"> <main class="layout-main" id="content"> <div class="container-fluid page-content"> <nav aria-label="breadcrumb" class="mt-2 iu-hide"> <form name="breadCrumbsForm" id="breadCrumbsForm" method="post"> <ol class="breadcrumb rounded"> <li class="breadcrumb-item"><a href="/">SFERA</a></li> <li class="breadcrumb-item"><a href="/handle/11392/2326068">ARIC UNIFE</a></li> <li class="breadcrumb-item"><a href="/handle/11392/2326073">03 Contributo in rivista (Pubblicazione in Rivista)</a></li> <li class="breadcrumb-item"><a href="/handle/11392/2326034">03.1 Articolo su rivista</a></li></ol> </form> </nav> <p class="searchIndexItemDescription abstractEng">Rationale: AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are marketed as incense, herbal preparations or chemical supply for their psychoactive Cannabis-like effects. Objectives: The present study was aimed at investigating the in vitro and in vivo pharmacological activity of AKB48 and 5F-AKB48 in male CD-1 mice and comparing their in vivo effects with those caused by the administration of Δ9-THC and JWH-018. Results: In vitro competition binding experiments performed on mouse and human CB1 and CB2 receptors revealed a nanomolar affinity and potency of the AKB48 and 5F-AKB48. In vivo studies showed that AKB48 and 5F-AKB48, induced hypothermia, increased pain threshold to both noxious mechanical and thermal stimuli, caused catalepsy, reduced motor activity, impaired sensorimotor responses (visual, acoustic and tactile), caused seizures, myoclonia, hyperreflexia and promoted aggressiveness in mice. Moreover, microdialysis study in freely moving mice showed that systemic administration of AKB48 and 5F-AKB48 stimulated dopamine release in the nucleus accumbens. Behavioural, neurological and neurochemical effects were fully prevented by the selective CB1 receptor antagonist/inverse agonist AM 251. Conclusions: For the first time, the present study demonstrates the overall pharmacological effects induced by the administration of AKB48 and 5F-AKB48 in mice and suggests that the fluorination can increase the power and/or effectiveness of SCBs. Furthermore, this study outlines the potential detrimental effects of SCBs on human health.</p> <div class="row"> <div class="col-lg-12 col-xl-9"> <div class="card"> <div class="card-body"> <div> <h3 class="mb-1 text-secondary">Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies</h3> <h5> <em><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp02399" class="authority author">CANAZZA, Isabella</a><sup class="ms-1"><h6 class="badge bg-dark">Co-primo</h6></sup>;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp01192" class="authority author">OSSATO, Andrea</a><sup class="ms-1"><h6 class="badge bg-dark">Co-primo</h6></sup>;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp05494" class="authority author">TRAPELLA, Claudio</a>;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp13053" class="authority author">FANTINATI, Anna</a>;</span><span class="contributor externalContributor externalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1 disabled" aria-disabled="true" style="display:none;">de Luca, Maria Antonietta;</span><span class="contributor externalContributor externalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1 disabled" aria-disabled="true" style="display:none;">Margiani, Giulia;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp07465" class="authority author">VINCENZI, Fabrizio</a>;</span><span class="contributor externalContributor externalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1 disabled" aria-disabled="true" style="display:none;">Rimondo, Claudia;</span><span class="contributor externalContributor externalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1 disabled" aria-disabled="true" style="display:none;">Di Rosa, Fabiana;</span><span class="contributor externalContributor externalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1 disabled" aria-disabled="true" style="display:none;">Gregori, Adolfo;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp04322" class="authority author">VARANI, Katia</a>;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp03381" class="authority author">BOREA, Pier Andrea</a>;</span><span class="contributor externalContributor externalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1 disabled" aria-disabled="true" style="display:none;">Serpelloni, Giovanni;</span><span class="contributor internalContributor internalContributore309adeb-926a-3969-e053-3a05fe0a2c94 m-1"><a href="/cris/rp/rp04676" class="authority author">MARTI, Matteo</a><sup class="ms-1"><h6 class="badge bg-info"><span class="fas fa-at" title="Corresponding author"></span></h6> <h6 class="badge bg-dark">Ultimo</h6></sup></span></em> <span onclick="JQ('.externalContributore309adeb-926a-3969-e053-3a05fe0a2c94').toggle();JQ('.showExternalTexte309adeb-926a-3969-e053-3a05fe0a2c94').toggle();JQ('.hideExternalTexte309adeb-926a-3969-e053-3a05fe0a2c94').toggle();" class="btn btn-sm btn-outline-secondary m-1"> <span class="showExternalTexte309adeb-926a-3969-e053-3a05fe0a2c94"><span class="fas fa-users" title="mostra contributor esterni"></span></span> <span class="hideExternalTexte309adeb-926a-3969-e053-3a05fe0a2c94" style="display:none;"><span class="fas fa-user" title="nascondi contributor esterni"></span></span> </span> </h5> <h5>2016</h5> <hr/> <h4 class="mb-1">Abstract</h4> Rationale: AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are marketed as incense, herbal preparations or chemical supply for their psychoactive Cannabis-like effects. Objectives: The present study was aimed at investigating the in vitro and in vivo pharmacological activity of AKB48 and 5F-AKB48 in male CD-1 mice and comparing their in vivo effects with those caused by the administration of Δ9-THC and JWH-018. Results: In vitro competition binding experiments performed on mouse and human CB1 and CB2 receptors revealed a nanomolar affinity and potency of the AKB48 and 5F-AKB48. In vivo studies showed that AKB48 and 5F-AKB48, induced hypothermia, increased pain threshold to both noxious mechanical and thermal stimuli, caused catalepsy, reduced motor activity, impaired sensorimotor responses (visual, acoustic and tactile), caused seizures, myoclonia, hyperreflexia and promoted aggressiveness in mice. Moreover, microdialysis study in freely moving mice showed that systemic administration of AKB48 and 5F-AKB48 stimulated dopamine release in the nucleus accumbens. Behavioural, neurological and neurochemical effects were fully prevented by the selective CB1 receptor antagonist/inverse agonist AM 251. Conclusions: For the first time, the present study demonstrates the overall pharmacological effects induced by the administration of AKB48 and 5F-AKB48 in mice and suggests that the fluorination can increase the power and/or effectiveness of SCBs. Furthermore, this study outlines the potential detrimental effects of SCBs on human health. </div> <div class="dspace-display-item tabbable page-tabs mt-3"> <h5> <ul class="nav nav-tabs border-bottom fw-bold"> <li class="nav-item"><a class="nav-link active" href="#tab_default" onclick="changeItemView('simple');" data-bs-toggle="tab">Scheda breve</a></li> <li class="nav-item"><a class="nav-link " href="#tab_default" onclick="changeItemView('complete');" data-bs-toggle="tab">Scheda completa</a></li> <li class="nav-item"><a class="nav-link " href="#tab_default" onclick="changeItemView('full');" data-bs-toggle="tab">Scheda completa (DC)</a></li> <li class="nav-item"><a class="nav-link" onclick="location.href='/cris/item/11392/2352324/statistics'" data-bs-toggle="tab"><span class="far fa-chart-bar"></span></a></li> </ul> </h5> <div class="tab-content"> <div class="tab-pane active fade show" id="tab_default"> <div class="itemDisplayTable container-fluid g-3"> <div class="line form-group row metadataFieldValue pt-2 pb-2 dc_date_issued" id="dc.date.issued_line" > <div class="line-label col-md-12"><label for="dc.date.issued" class="control-label metadataFieldLabel dc_date_issued"> <span class="line-label-text">Anno di pubblicazione</span> </label></div> <div class="line-content col-sm-12" id="dc.date.issued_content"> <em>2016</em> </div> </div> <div class="line form-group row metadataFieldValue pt-2 pb-2 dc_identifier_doi" id="dc.identifier.doi_line" > <div class="line-label col-md-12"><label for="dc.identifier.doi" class="control-label metadataFieldLabel dc_identifier_doi"> <span class="line-label-text">DOI</span> </label></div> <div class="line-content col-sm-12" id="dc.identifier.doi_content"> <em><a href="https://dx.doi.org/10.1007/s00213-016-4402-y" target="_blank" rel="noopener">https://dx.doi.org/10.1007/s00213-016-4402-y</a></em> </div> </div> <div class="line form-group row metadataFieldValue pt-2 pb-2 dc_authority_ancejournal" id="dc.authority.ancejournal_line" > <div class="line-label col-md-12"><label for="dc.authority.ancejournal" class="control-label metadataFieldLabel dc_authority_ancejournal"> <span class="line-label-text">Titolo della Rivista</span> </label></div> <div class="line-content col-sm-12" id="dc.authority.ancejournal_content"> <em><a href="/rm/popup/rmItem/journal/crisId/journal42695/detail.htm" target="_blank" onclick="showPopup('/rm/popup/rmItem/journal/crisId/journal42695/detail.htm'); return false;" class="authority "><span class="me-1">PSYCHOPHARMACOLOGY</span></a></em> </div> </div> <div class="line form-group row metadataFieldValue pt-2 pb-2 dc_description_allpeople" id="dc.description.allpeople_line" > <div class="line-label col-md-12"><label for="dc.description.allpeople" class="control-label metadataFieldLabel dc_description_allpeople"> <span class="line-label-text">Tutti gli autori</span> </label></div> <div class="line-content col-sm-12" id="dc.description.allpeople_content"> <span id="dc.description.allpeople_inner">Canazza, Isabella; Ossato, Andrea; Trapella, Claudio; Fantinati, Anna; de Luca, Maria Antonietta; Margiani, Giulia; Vincenzi, Fabrizio; Rimondo, Claud</span><span id="dc.description.allpeople_redux">...<span style='cursor:pointer' onclick='init()'><u>espandi</u></span></span> <script>var reduxStatus="reduxed";</script> </div> </div> <script type="text/javascript"> var peopleText="<em>Canazza, Isabella; Ossato, Andrea; Trapella, Claudio; Fantinati, Anna; de Luca, Maria Antonietta; Margiani, Giulia; Vincenzi, Fabrizio; Rimondo, Claudia; Di Rosa, Fabiana; Gregori, Adolfo; Varani, Katia; Borea, Pier Andrea; Serpelloni, Giovanni; Marti, Matteo</em>"; var peopleReduxSize="150"; var peopleTextReduced="Canazza, Isabella; Ossato, Andrea; Trapella, Claudio; Fantinati, Anna; de Luca, Maria Antonietta; Margiani, Giulia; Vincenzi, Fabrizio; Rimondo, Claud"; //var firstPeopleButton=false; //document.getElementById("dc.description.allpeople_inner").addEventListener('load',function(){ function init(){ if(peopleText.length<=peopleReduxSize){ peopleReduxText=peopleText; }else{ //peopleReduxText=peopleText.substring(peopleText,0,peopleReduxSize); //document.getElementById("dc.description.allpeople_inner").innerHtml=peopleReduxText; //reduxStatus="reduxed"; //document.getElementById("dc.description.allpeople_redux").innerHTML="... <button type='button' class='btn btn-success' onclick='init()'><b>+</b></button>"; if(reduxStatus=="reduxed"){ document.getElementById("dc.description.allpeople_inner").innerHTML=peopleText; reduxStatus="expanded"; firstPeopleButton=true; document.getElementById("dc.description.allpeople_redux").innerHTML="<span style='cursor:pointer' onclick='init()'> <u>comprimi</u></span>"; } else if(reduxStatus=="expanded"){ document.getElementById("dc.description.allpeople_inner").innerHTML=peopleTextReduced; reduxStatus="reduxed"; firstPeopleButton=true; document.getElementById("dc.description.allpeople_redux").innerHTML="...<span style='cursor:pointer' onclick='init()'><u>espandi</u></span>"; } } } //,false); //init(); </script> <div class="line form-group row metadataFieldValue pt-2 pb-2 dspace_collection" id="dspace_collection_line" > <div class="line-label col-md-12"><label for="dspace_collection" class="control-label metadataFieldLabel dspace_collection"> <span class="line-label-text">Appare nelle tipologie:</span> </label></div> <div class="line-content col-sm-12" id="dspace_collection_content"> <a href="/handle/11392/2326034">03.1 Articolo su rivista</a> </div> </div> </div> </div> </div> </div></div> </div> <script type="text/x-tmpl" id="tmpLicenseDetail"> <div class="d-flex align-items-center"> {% if (o.licenseImage != null) { %} <div class="flex-shrink-0"> <img src="{%= o.licenseImage %}" /> </div> {% } %} <div class="flex-grow-1 ms-3"> {%# o.licenseName %} </div> </div> </script> <div id="bitstreams" class="card bg-white mt-2"> <div class="card-header">File in questo prodotto:</div> <table class="table card-body"> <tr> <th id="t1" class="standard">File</th> <th id="t3" class="standard d-none d-sm-table-cell">Dimensione</th> <th id="t4" class="standard d-none d-sm-table-cell">Formato</th> <th id="t5" class="standard d-none d-sm-table-cell"> </th> </tr> <tr> <td headers="t1" class="standard break-all"> CANAZZA 2016 Psychophamacology.pdf <p class="badge bg-info">solo gestori archivio</p> <div class="col-12 mb-2"> Descrizione: versione editoriale </div> <div class="col-12 mb-2"> Tipologia: Full text (versione editoriale) </div> <div class="col-12 mb-2"> Licenza: NON PUBBLICO - Accesso privato/ristretto </div> <div class="col-12 mb-2 d-block d-sm-none"> Dimensione 3.27 MB </div> <div class="col-12 mb-2 d-block d-sm-none"> Formato Adobe PDF </div> <div class="col-12 mb-2 d-block d-sm-none"> <a class="btn btn-warning" target="_blank" rel="noopener" href="/retrieve/e309ade1-1902-3969-e053-3a05fe0a2c94/CANAZZA%202016%20Psychophamacology.pdf"><span class="fas fa-lock"></span>  Visualizza/Apri</a> <a class="btn btn-warning" href="/request-item?handle=11392/2352324&bitstreamId=e309ade1-1902-3969-e053-3a05fe0a2c94"><span class="fas fa-lock"></span>  Richiedi una copia</a> </div> </td> <td headers="t3" class="standard d-none d-sm-table-cell">3.27 MB</td> <td headers="t4" class="standard d-none d-sm-table-cell">Adobe PDF</td> <td class="standard d-none d-sm-table-cell"> <a class="btn btn-warning" target="_blank" rel="noopener" href="/retrieve/e309ade1-1902-3969-e053-3a05fe0a2c94/CANAZZA%202016%20Psychophamacology.pdf"><span class="fas fa-lock"></span>  Visualizza/Apri</a> <a class="btn btn-warning" href="/request-item?handle=11392/2352324&bitstreamId=e309ade1-1902-3969-e053-3a05fe0a2c94"><span class="fas fa-lock"></span>  Richiedi una copia</a> </td> </tr> <tr> <td headers="t1" class="standard break-all"> MARTI 11392-2352324 pre-print.pdf <p class="badge bg-info">accesso aperto</p> <div class="col-12 mb-2"> Descrizione: pre print </div> <div class="col-12 mb-2"> Tipologia: Pre-print </div> <div class="col-12 mb-2"> Licenza: PUBBLICO - Pubblico con Copyright </div> <div class="col-12 mb-2 d-block d-sm-none"> Dimensione 5.7 MB </div> <div class="col-12 mb-2 d-block d-sm-none"> Formato Adobe PDF </div> <div class="col-12 mb-2 d-block d-sm-none"> <a class="btn btn-success" target="_blank" rel="noopener" href="/retrieve/e309ade3-ff1b-3969-e053-3a05fe0a2c94/MARTI%2011392-2352324%20pre-print.pdf">Visualizza/Apri</a> </div> </td> <td headers="t3" class="standard d-none d-sm-table-cell">5.7 MB</td> <td headers="t4" class="standard d-none d-sm-table-cell">Adobe PDF</td> <td class="standard d-none d-sm-table-cell"> <a class="btn btn-success" target="_blank" rel="noopener" href="/retrieve/e309ade3-ff1b-3969-e053-3a05fe0a2c94/MARTI%2011392-2352324%20pre-print.pdf">Visualizza/Apri</a> </td> </tr> </table> </div> <div class="col-lg-12 mt-2"> </div> <div class="col-lg-12 mt-2"> <p class="submitFormHelp alert alert-info">I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.</p> </div> </div> <div class="col-lg-12 col-xl-3" id="itemInformationsDiv"> <div id="_line" > <div class="accordion" id="accordion_"> <div class="accordion-item"> <h5 class="accordion-header" id="heading_"> <button class="accordion-button bg-info bg-opacity-25 collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse_" aria-expanded="false" aria-controls="collapse_"><i class="fas fa-info-circle"></i> Informazioni</button> </h5> <div id="collapse_" class="accordion-collapse collapse show" aria-labelledby="heading_" data-bs-parent="#accordion_"> <div class="accordion-body"> Utilizza questo identificativo per citare o creare un link a questo documento: <code>https://hdl.handle.net/11392/2352324</code> </div> </div> </div> </div> </div> <script type="text/javascript"> runningExternal=false; </script> <div class="card border-white mt-2" > <div class="card-header bg-white text-primary"><h5>Citazioni</h5></div> <ul class="list-group list-group-flush"> <li class="list-group-item d-flex justify-content-between align-items-start"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/27527584" target="_blank" rel="noopener"><img src="https://sfera.unife.it/sr/cineca/images/thirdparty/pmc_small.png" style="height: 18px;" alt="???jsp.display-item.citation.pmc???"/></a> <span class="badge bg-secondary rounded-pill" data-bs-toggle="tooltip" data-bs-placement="left" id="pmcCitedResultTotal" title="aggiornato in data 23-11-2024 15:33" >29</span> </li> <script type="text/javascript"> $(document).ready(function() { pmcUpdateCitationQueue(false); }); </script> <script type="text/javascript"> var pmcChartData = []; pmcChartData[0] = 0; pmcChartData[1] = 0; pmcChartData[2] = 0; pmcChartData[3] = 0; pmcChartData[4] = 0; pmcChartData[5] = 0; function pmcUpdateCitationQueue(forceUpdate) { //console.log('call pmcUpdateCitation'); if (runningExternal) { var rnd=Math.floor(Math.random() * (2000 + 1) + 1000); //console.log('wait pmcUpdateCitation for '+rnd); setTimeout(() => { pmcUpdateCitationQueue(forceUpdate); }, rnd); } else { //console.log('executing pmcUpdateCitation'); runningExternal=true; pmcUpdateCitation(forceUpdate) } } function pmcUpdateCitation(forceUpdate) { $('#pmcCitedResultTotal').append('<div class="spinner-border spinner-border-sm ms-2" role="status"></div>'); $.ajax({ url: '/itemExternalCitation/pmc/get.json', dataType: 'json', data: { discriminator: 'pmc', itemId: 'e309adeb-926a-3969-e053-3a05fe0a2c94', forceUpdate: forceUpdate } }).done(function(adata) { $('#pmcCitedResultTotal').tooltip('dispose'); $('#pmcCitedResultTotal').prop("onclick", null).off("click"); if (adata.total==null){ $('#pmcCitedResultTotal').html('29'); } else { $('#pmcCitedResultTotal').html(adata.total); } var year=new Date().getFullYear(); pmcChartData[0] = (adata.yearTotalMap[''+(year-5)]!=null ? adata.yearTotalMap[''+(year-5)] : 0); pmcChartData[1] = (adata.yearTotalMap[''+(year-4)]!=null ? adata.yearTotalMap[''+(year-4)] : 0); pmcChartData[2] = (adata.yearTotalMap[''+(year-3)]!=null ? adata.yearTotalMap[''+(year-3)] : 0); pmcChartData[3] = (adata.yearTotalMap[''+(year-2)]!=null ? adata.yearTotalMap[''+(year-2)] : 0); pmcChartData[4] = (adata.yearTotalMap[''+(year-1)]!=null ? adata.yearTotalMap[''+(year-1)] : 0); pmcChartData[5] = (adata.yearTotalMap[''+year]!=null ? adata.yearTotalMap[''+year] : 0); drawChart(); }).always(function(adata){ //console.log('end pmcUpdateCitation'); runningExternal=false; }); } </script> <li class="list-group-item d-flex justify-content-between align-items-start"> <a href="http://www.scopus.com/inward/record.url?partnerID=3MLxHJVE&origin=inward&eid=2-s2.0-84982095239" target="_blank" rel="noopener"><img src="https://sfera.unife.it/sr/cineca/images/thirdparty/scopus_small.png" style="height: 18px;" alt="Scopus"/></a> <span class="badge bg-secondary rounded-pill" data-bs-toggle="tooltip" data-bs-placement="left" id="scopusCitedResultTotal" title="aggiornato in data 24-11-2024 18:05" >68</span> </li> <script type="text/javascript"> $(document).ready(function() { scopusUpdateCitationQueue(false); }); </script> <script type="text/javascript"> var scopusChartData = []; scopusChartData[0] = 0; scopusChartData[1] = 0; scopusChartData[2] = 0; scopusChartData[3] = 0; scopusChartData[4] = 0; scopusChartData[5] = 0; function scopusUpdateCitationQueue(forceUpdate) { //console.log('call scopusUpdateCitation'); if (runningExternal) { var rnd=Math.floor(Math.random() * (2000 + 1) + 1000); //console.log('wait scopusUpdateCitation for '+rnd); setTimeout(() => { scopusUpdateCitationQueue(forceUpdate); }, rnd); } else { //console.log('executing scopusUpdateCitation'); runningExternal=true; scopusUpdateCitation(forceUpdate) } } function scopusUpdateCitation(forceUpdate) { $('#scopusCitedResultTotal').append('<div class="spinner-border spinner-border-sm ms-2" role="status"></div>'); $.ajax({ url: '/itemExternalCitation/scopus/get.json', dataType: 'json', data: { discriminator: 'scopus', itemId: 'e309adeb-926a-3969-e053-3a05fe0a2c94', forceUpdate: forceUpdate } }).done(function(adata) { $('#scopusCitedResultTotal').tooltip('dispose'); $('#scopusCitedResultTotal').prop("onclick", null).off("click"); if (adata.total==null){ $('#scopusCitedResultTotal').html('68'); } else { $('#scopusCitedResultTotal').html(adata.total); } var year=new Date().getFullYear(); scopusChartData[0] = (adata.yearTotalMap[''+(year-5)]!=null ? adata.yearTotalMap[''+(year-5)] : 0); scopusChartData[1] = (adata.yearTotalMap[''+(year-4)]!=null ? adata.yearTotalMap[''+(year-4)] : 0); scopusChartData[2] = (adata.yearTotalMap[''+(year-3)]!=null ? adata.yearTotalMap[''+(year-3)] : 0); scopusChartData[3] = (adata.yearTotalMap[''+(year-2)]!=null ? adata.yearTotalMap[''+(year-2)] : 0); scopusChartData[4] = (adata.yearTotalMap[''+(year-1)]!=null ? adata.yearTotalMap[''+(year-1)] : 0); scopusChartData[5] = (adata.yearTotalMap[''+year]!=null ? adata.yearTotalMap[''+year] : 0); drawChart(); }).always(function(adata){ //console.log('end scopusUpdateCitation'); runningExternal=false; }); } </script> <li class="list-group-item d-flex justify-content-between align-items-start"> <a href="https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=CINECA&SrcAuth=WosAPI&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000385518500003" target="_blank" rel="noopener"><img src="https://sfera.unife.it/sr/cineca/images/thirdparty/isi_small.png" style="height: 18px;" alt="???jsp.display-item.citation.isi???"/></a> <span class="badge bg-secondary rounded-pill" data-bs-toggle="tooltip" data-bs-placement="left" id="isiCitedResultTotal" title="aggiornato in data 23-11-2024 23:21" >63</span> </li> <script type="text/javascript"> $(document).ready(function() { isiUpdateCitationQueue(false); }); </script> <script type="text/javascript"> var isiChartData = []; isiChartData[0] = 0; isiChartData[1] = 0; isiChartData[2] = 0; isiChartData[3] = 0; isiChartData[4] = 0; isiChartData[5] = 0; function isiUpdateCitationQueue(forceUpdate) { //console.log('call isiUpdateCitation'); if (runningExternal) { var rnd=Math.floor(Math.random() * (2000 + 1) + 1000); //console.log('wait isiUpdateCitation for '+rnd); setTimeout(() => { isiUpdateCitationQueue(forceUpdate); }, rnd); } else { //console.log('executing isiUpdateCitation'); runningExternal=true; isiUpdateCitation(forceUpdate) } } function isiUpdateCitation(forceUpdate) { $('#isiCitedResultTotal').append('<div class="spinner-border spinner-border-sm ms-2" role="status"></div>'); $.ajax({ url: '/itemExternalCitation/isi/get.json', dataType: 'json', data: { discriminator: 'isi', itemId: 'e309adeb-926a-3969-e053-3a05fe0a2c94', forceUpdate: forceUpdate } }).done(function(adata) { $('#isiCitedResultTotal').tooltip('dispose'); $('#isiCitedResultTotal').prop("onclick", null).off("click"); if (adata.total==null){ $('#isiCitedResultTotal').html('63'); } else { $('#isiCitedResultTotal').html(adata.total); } var year=new Date().getFullYear(); isiChartData[0] = (adata.yearTotalMap[''+(year-5)]!=null ? adata.yearTotalMap[''+(year-5)] : 0); isiChartData[1] = (adata.yearTotalMap[''+(year-4)]!=null ? adata.yearTotalMap[''+(year-4)] : 0); isiChartData[2] = (adata.yearTotalMap[''+(year-3)]!=null ? adata.yearTotalMap[''+(year-3)] : 0); isiChartData[3] = (adata.yearTotalMap[''+(year-2)]!=null ? adata.yearTotalMap[''+(year-2)] : 0); isiChartData[4] = (adata.yearTotalMap[''+(year-1)]!=null ? adata.yearTotalMap[''+(year-1)] : 0); isiChartData[5] = (adata.yearTotalMap[''+year]!=null ? adata.yearTotalMap[''+year] : 0); drawChart(); }).always(function(adata){ //console.log('end isiUpdateCitation'); runningExternal=false; }); } </script> <li class="list-group-item d-flex justify-content-between align-items-start" style="display: none;" id="citation_chart_panel"> <div id="citation_chart" style="width: 100%;"></div> <script type="text/javascript"> $('#citation_chart').html('<span class="fas fa-shield" title="il componente non può essere visualizzato perché i cookie di terze parti sono stati disabilitati. Riabilitarli tramite il pannello Utilizzo dei cookie situato a fondo pagina"><span> '); </script> </li> </ul> </div> <div class="card border-white mt-2" > <div class="card-header bg-white text-primary"><h5>social impact</h5></div> <ul class="list-group list-group-flush"> <li class="list-group-item d-flex justify-content-between align-items-start"> <a id="plumx" href="https://plu.mx/plum/a/?doi=10.1007/s00213-016-4402-y" class="plumx-plum-print-popup"></a> <script type="text/javascript"> if (isThirdPartyCookieEnabled()) { $.getScript("//cdn.plu.mx/widget-popup.js", function() { }); } else { $('#plumx').attr('href','#').html('<span class="fas fa-shield" title="il componente non può essere visualizzato perché i cookie di terze parti sono stati disabilitati. Riabilitarli tramite il pannello Utilizzo dei cookie situato a fondo pagina"><span> '); } </script> </li> </ul> </div> </div> </div> <div id="dialog-confirm-delete" class="modal"> <div class="modal-dialog "> <div class="modal-content"> <div class="modal-header bg-success text-white"> <h5 id="dialog-confirm-delete_title" class="modal-title"> Conferma cancellazione </h5> <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div id="dialog-confirm-delete_content" class="modal-body with-padding"> <p class="message">Sei sicuro che questo prodotto debba essere cancellato?</p> </div> <div id="dialog-confirm-delete_footer" class="modal-footer bg-light"> <button type="button" class="btn btn-secondary " data-bs-dismiss="modal"> Chiudi </button> <button type="button" id="button-confirm-delete" class="btn btn-secondary " > Elimina </button> </div> </div> </div> </div> <script type="text/javascript"> var modeNow; function changeItemView(mode) { $('#tab_default').html('<i class="fas fa-spinner fa-pulse fa-3x fa-fw mt-3"></i>'); $.ajax({ url: '/fragment/handle/11392/2352324', data: { mode: mode, descriptionAbstractUsedField: 'dc.description.abstracteng' } }).done(function(data) { modeNow=mode; $('#tab_default').html(data); //change url //var href="/handle/11392/2352324"; var href=window.location.href; if (!href.includes("mode=")) { if (!href.includes("?")) href+='?mode='+mode; else href+='&mode='+mode; } else href=href.replace( /(mode=)[a-z]+/ig, '$1'+mode ); window.history.pushState("", "", href); }); } function getUrlVars() { var vars = {}; var parts = window.location.href.replace(/[?&]+([^=&]+)=([^&]*)/gi, function(m,key,value) { vars[key] = value; }); return vars; } j('#button-confirm-delete').click(function() { location.href='/item/version/reinstateOrWithdraw.htm?itemId=' + 'e309adeb-926a-3969-e053-3a05fe0a2c94'; }); j('#button-confirm-force-delete').click(function() { location.href='/item/version/reinstateOrWithdraw.htm?forceWithdraw=true&itemId=' + 'e309adeb-926a-3969-e053-3a05fe0a2c94'; }); function getSOLR() { $('li a.nav-link active').removeClass('active'); $('#linkSOLR').addClass('active'); $('#tab_default').html('<i class="fas fa-spinner fa-pulse fa-3x fa-fw mt-3"></i>'); $.ajax('/itemSolr/get.json?itemUUID=e309adeb-926a-3969-e053-3a05fe0a2c94') .done(function(data) { $('#tab_default').html('<pre>'+JSON.stringify(data, null,' ')+'</pre>'); }); } </script> <script type="text/javascript"> function showAbout() { jQuery.ajax({ url: "/about.modal", type: 'GET', success: function(data) { var $modal = jQuery(data); jQuery('body').append($modal); $modal.filter('.modal').modal('show'); $modal.filter('.modal').on('hidden.bs.modal', function(){ $modal.remove(); }); $modal.attr('id','modal_about'); $modal.modal('show') }, error: function(data,extStatus, errorThrown) { $.jGrowl('errore generico di comunicazione', { sticky: true, theme: 'bg-danger text-white' }); } }); } function showCookies() { showCookieSettings(); } function showPrivacyInfo() { window.open('/aboutPrivacyInfo.htm', '_blank').focus(); } </script> <script type="text/javascript"> function asn1820List() { jQuery('#asn1820-div').modal('show'); } </script> <div class="modal fade" id="asn1820-div" tabindex="-1" role="dialog" aria-labelledby="asn1820Label" aria-hidden="true"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <h4 class="modal-title" id="asn1820Label">simulazione ASN</h4> <button type="button" class="btn-close" data-bs-dismiss="modal" aria-hidden="true"></button> </div> <div class="modal-body with-padding"> Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione.<br/>La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.<br/><br/>La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.</div> <div class="modal-footer"> <button type="button" class="btn btn-secondary" data-bs-dismiss="modal">Annulla</button> <button type="button" class="btn btn-primary" onclick="location.href='/bi/asn1820/widgetSearch.htm?CLEAR&dataType=MA'">procedi</button> </div> </div> </div> </div> <div class="modal fade" id="genericFragmentErrorModal" tabindex="-1" role="dialog" aria-labelledby="modal-title" aria-hidden="true" style="z-index: 10000"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <h4 class="modal-title">Errore</h4> <button aria-hidden="true" data-bs-dismiss="modal" class="btn-close" type="button"></button> </div> <div class="modal-body with-padding"> <div class="callout alert bg-danger"> <h5>Errore</h5> <p id="genericFragmentErrorModalContent"></p> </div> </div> </div> </div> </div> <script type="text/javascript"> var forceLogindModuleMap = reloadInit(['bi','rm','gw','ma','','saiku','ap']); </script> </div> </main> </div> <div class="clearfix"></div> <footer class="bd-footer py-2 mt-2 bg-light d-flex justify-content-between fw-bold iu-hide"> <div class="ms-2"> Powered by <a class="text-decoration-none" href="https://www.cineca.it/sistemi-informativi-universita/ricerca/iris-la-gestione-della-ricerca">IRIS</a> <span style="margin-left: 10px; margin-right: 10px;">-</span> <a class="text-decoration-none" onclick="showAbout();" href="#">about IRIS</a> <span style="margin-left: 10px; margin-right: 10px;">-</span> <a class="text-decoration-none" onclick="showCookies();" href="#">Utilizzo dei cookie</a></div> <div class="me-2"> <a href="http://www.cineca.it" target="_blank"><img alt="Logo CINECA" height="15px;" src="/sr/cineca/images/interface/logo-cineca-small-white.png"></a> <span> Copyright © 2024 </span><a href="/htmlmap" style="display:none;"></a></div> </footer></body> </html>

CINXE.COM

Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies