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He leads the Mouse Genomics Team, which uses the mouse as a model system to investigate the function of individual gene. </p> <p> He received his BA, MA and PhD in Genetics from University of Cambridge and his PhD studies in Martin Evans laboratory laid the foundation for making knockout mice. </p><div class="cPic right" style="width:240px"><a href="/web/20131113144014/http://www.sanger.ac.uk/about/people/gfx/team_82_group_wtsi_1000x750_72.jpg" class="thickbox" title="Allan Bradley and the Mouse Genomics team, which he leads at the Sanger Instititute. [Genome Research Limited]"><img src="/web/20131113144014im_/http://www.sanger.ac.uk/t/img/BSmh92DDGXPiPuFD03Smbg.jpg" style="width:220px;height:165px;" alt="Allan Bradley and the Mouse Genomics team."/></a><p style="width:220px">Allan Bradley and the Mouse Genomics team. [Genome Research Limited]<br/><a href="/web/20131113144014/http://www.sanger.ac.uk/about/people/gfx/team_82_group_wtsi_1000x750_72.jpg" class="thickbox" title="Allan Bradley and the Mouse Genomics team, which he leads at the Sanger Instititute. [Genome Research Limited]"><img src="/web/20131113144014im_/http://www.sanger.ac.uk/core/gfx/blank.gif" alt="Enlarge this image (1000 x 750)"/></a></p></div> <p> In 1984 Allan Bradley and Liz Robertson demonstrated that embryonic stem (ES) cells could be transmitted through the germ line of mice and two years later reported that ES cells could be used to generate mice with mutations in endogenous genes. This work contributed to the award of the Nobel Prize in Physiology or Medicine to Martin Evans in 2007. </p> <p> In 1987, Allan took up an appointment as an Assistant Professor at Baylor College of Medicine, Houston Texas. He was appointed a Howard Hughes Medical Institute Investigator in 1993 and was promoted to full Professor in 1994. At The Baylor College of Medicine, his laboratory played a seminal role in developing the techniques, technology and tools for genetic manipulation in the mouse. As a result mice can now be generated with changes as subtle as an alteration in a single nucleotide or as massive as the deletion, duplication or inversion of millions of base pairs, a technology that has become known as chromosome engineering. Allan Bradley's laboratory have used ES cell technology extensively, generating and analysing many of the first generation of mouse knockouts as well as helping numerous other laboratories to utilize this technology. This work has provided key functional information on many genes with an emphasis on cancer, DNA repair and embryonic development. </p> <p> In 2000, Allan returned to the United Kingdom as Director of the Sanger Centre, now called the Wellcome Trust Sanger Institute. He has established a new direction for the Institute - genetic analysis of gene function, which includes among other projects the largest systematic gene knockout project ever attempted in ES cells funded by the European Union (EUCOMM) and National Institutes of Health (KOMP). </p> <p> In 2002 Allan Bradley was honoured by election to the Royal Society. Allan runs an active research group of students and fellows who continue to develop tools and technologies for new mouse genetics as well as to explore gene function on a large scale. </p> </div> <div class="panel"> <h2>Selected Publications</h2><ul class="references"><li class="periodical"> <h4 class="article">Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.</h4> <p class="authors"><span class="author">Guo G</span>, <span class="author">Wang W</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">2004</span>;<span class="volume">429</span>;<span class="number">6994</span>;<span class="pagerange">891-5</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/15215866">15215866</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2Fnature02653">10.1038/nature02653</a></p></li><li class="periodical"> <h4 class="article">Functional genetic analysis of mouse chromosome 11.</h4> <p class="authors"><span class="author">Kile BT</span>, <span class="author">Hentges KE</span>, <span class="author">Clark AT</span>, <span class="author">Nakamura H</span>, <span class="author">Salinger AP</span>, <span class="author">Liu B</span>, <span class="author">Box N</span>, <span class="author">Stockton DW</span>, <span class="author">Johnson RL</span>, <span class="author">Behringer RR</span>, <span class="author">Bradley A</span> and <span class="author">Justice MJ</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">2003</span>;<span class="volume">425</span>;<span class="number">6953</span>;<span class="pagerange">81-6</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/12955145">12955145</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2Fnature01865">10.1038/nature01865</a></p></li><li class="periodical"> <h4 class="article">Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.</h4> <p class="authors"><span class="author">Sharan SK</span>, <span class="author">Morimatsu M</span>, <span class="author">Albrecht U</span>, <span class="author">Lim DS</span>, <span class="author">Regel E</span>, <span class="author">Dinh C</span>, <span class="author">Sands A</span>, <span class="author">Eichele G</span>, <span class="author">Hasty P</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1997</span>;<span class="volume">386</span>;<span class="number">6627</span>;<span class="pagerange">804-10</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/9126738">9126738</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2F386804a0">10.1038/386804a0</a></p></li><li class="periodical"> <h4 class="article">Chromosome engineering in mice.</h4> <p class="authors"><span class="author">Ramírez-Solis R</span>, <span class="author">Liu P</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1995</span>;<span class="volume">378</span>;<span class="number">6558</span>;<span class="pagerange">720-4</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/7501018">7501018</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2F378720a0">10.1038/378720a0</a></p></li><li class="periodical"> <h4 class="article">Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.</h4> <p class="authors"><span class="author">Jones SN</span>, <span class="author">Roe AE</span>, <span class="author">Donehower LA</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1995</span>;<span class="volume">378</span>;<span class="number">6553</span>;<span class="pagerange">206-8</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/7477327">7477327</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2F378206a0">10.1038/378206a0</a></p></li><li class="periodical"> <h4 class="article">Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.</h4> <p class="authors"><span class="author">Lee EY</span>, <span class="author">Chang CY</span>, <span class="author">Hu N</span>, <span class="author">Wang YC</span>, <span class="author">Lai CC</span>, <span class="author">Herrup K</span>, <span class="author">Lee WH</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1992</span>;<span class="volume">359</span>;<span class="number">6393</span>;<span class="pagerange">288-94</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/1406932">1406932</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2F359288a0">10.1038/359288a0</a></p></li><li class="periodical"> <h4 class="article">Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.</h4> <p class="authors"><span class="author">Donehower LA</span>, <span class="author">Harvey M</span>, <span class="author">Slagle BL</span>, <span class="author">McArthur MJ</span>, <span class="author">Montgomery CA</span>, <span class="author">Butel JS</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1992</span>;<span class="volume">356</span>;<span class="number">6366</span>;<span class="pagerange">215-21</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/1552940">1552940</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2F356215a0">10.1038/356215a0</a></p></li><li class="periodical"> <h4 class="article">The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.</h4> <p class="authors"><span class="author">McMahon AP</span> and <span class="author">Bradley A</span></p> <p class="publication"><span class="title">Cell</span> <span class="year">1990</span>;<span class="volume">62</span>;<span class="number">6</span>;<span class="pagerange">1073-85</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/2205396">2205396</a></p></li><li class="periodical"> <h4 class="article">A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice.</h4> <p class="authors"><span class="author">Kuehn MR</span>, <span class="author">Bradley A</span>, <span class="author">Robertson EJ</span> and <span class="author">Evans MJ</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1987</span>;<span class="volume">326</span>;<span class="number">6110</span>;<span class="pagerange">295-8</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/3029599">3029599</a>; DOI: <a href="https://web.archive.org/web/20131113144014/http://dx.doi.org/10.1038%2F326295a0">10.1038/326295a0</a></p></li><li class="periodical"> <h4 class="article">Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines.</h4> <p class="authors"><span class="author">Bradley A</span>, <span class="author">Evans M</span>, <span class="author">Kaufman MH</span> and <span class="author">Robertson E</span></p> <p class="publication"><span class="title">Nature</span> <span class="year">1984</span>;<span class="volume">309</span>;<span class="number">5965</span>;<span class="pagerange">255-6</span></p> <p class="links">PUBMED: <a href="https://web.archive.org/web/20131113144014/http://ukpmc.ac.uk/abstract/MED/6717601">6717601</a></p></li></ul> </div> </div> <div id="rhs"> <div class="panel rhs_print"> <div class="facultyImage" style="background-image:url(/web/20131113144014im_/http://www.sanger.ac.uk/i/people/mid/allan_bradley_wt_c0056607_160x250_72.jpg)"></div><p class="portrait">[Wellcome Library, London]</p> <dl class="twocol"> <dt> Allan's Project </dt> <dd> <a href="/web/20131113144014/http://www.sanger.ac.uk/research/projects/mousegenomics/">Mouse genomics - Bradley laboratory</a> </dd> <dt> Research Area </dt> <dd> <a href="/web/20131113144014/http://www.sanger.ac.uk/research/areas/mouseandzebrafish/">Mouse and zebrafish genetics</a> </dd> <dt> Email </dt> <dd> <a href="https://web.archive.org/web/20131113144014/mailto:%61%62%72%61%64%6c%65%79%40%73%61%6e%67%65%72%2e%61%63%2e%75%6b">abradley@sanger.ac.uk</a> </dd>  </dl> </div> <div class="panel"> <h3>Related links:</h3> <ul> <li> <a href="/web/20131113144014/http://www.sanger.ac.uk/about/history/history.html">History</a> </li> <li> <a href="/web/20131113144014/http://www.sanger.ac.uk/research/projects/mousegenomics/">Mouse Genomics Group</a> </li> <li> <a href="/web/20131113144014/http://www.sanger.ac.uk/about/people/jsulston.html">John Sulston</a> </li> <li> <a href="/web/20131113144014/http://www.sanger.ac.uk/about/people/management.html">Key personnel</a> </li> </ul> </div> </div> </div> <div id="wrapB"><div id="wrapBL"></div><div id="wrapBR"></div></div> <div class="qr"><a href="https://web.archive.org/web/20131113144014/http://q.sanger.ac.uk/weceylp0"><img alt="* quick link - http://q.sanger.ac.uk/weceylp0" src="/web/20131113144014im_/http://www.sanger.ac.uk/qr/weceylp0.png"/></a></div> <div id="footer"> <ul id="footer_links"> <li><a href="/web/20131113144014/http://www.sanger.ac.uk/help/">Help</a></li> <li> | </li> <li><a href="/web/20131113144014/http://www.sanger.ac.uk/about/contact/">Contact us</a></li> <li> |</li> <li><a href="/web/20131113144014/http://www.sanger.ac.uk/legal/">Legal</a></li> <li> | </li> <li><a href="/web/20131113144014/http://www.sanger.ac.uk/legal/cookiespolicy.html">Cookies policy</a></li> <li> | </li>  <li><a href="/web/20131113144014/http://www.sanger.ac.uk/datasharing/">Data sharing</a></li> </ul> <ul class="social"> <li class="connect">Connect with us: </li> <li class="fb"><a href="https://web.archive.org/web/20131113144014/https://www.facebook.com/sangerinstitute"><img src="/web/20131113144014im_/http://www.sanger.ac.uk/core/gfx/blank.gif" title="Connect with us on Facebook" alt="Connect with us on Facebook"/></a></li> <li class="tw"><a href="https://web.archive.org/web/20131113144014/https://twitter.com/sangerinstitute"><img src="/web/20131113144014im_/http://www.sanger.ac.uk/core/gfx/blank.gif" title="Follow up on Twitter" alt="Follow us on Twitter"/></a></li> <li class="yt"><a href="https://web.archive.org/web/20131113144014/http://www.youtube.com/user/sangerinstitute"><img src="/web/20131113144014im_/http://www.sanger.ac.uk/core/gfx/blank.gif" title="View us on Youtube" alt="View us on Youtube"/></a></li> <li class="wp"><a href="https://web.archive.org/web/20131113144014/http://sangerinstitute.wordpress.com/"><img src="/web/20131113144014im_/http://www.sanger.ac.uk/core/gfx/blank.gif" title="Read our blog" alt="Read our blog"/></a></li> </ul> <div class="charity"> <div id="footer_print"> Unless otherwise stated the content of this website is copyright Wellcome Trust Sanger Institute, licenced under the Creative Commons Attribution-Noncommercial-No Derivative Works 2.5 Licence. </div> Wellcome Trust Sanger Institute, Genome Research Limited (reg no. 2742969) is a charity registered in England with number 1021457<br/> Last modified: Wed, 30 Jan 2013 10:53:27 GMT </div> </div> </div> <noscript><div><img src="/web/20131113144014im_/http://www.sanger.ac.uk/piwik.php" alt="" style="width:1px;height:1px"/></div></noscript> <script type="text/javascript" src="/web/20131113144014js_/http://www.sanger.ac.uk/t/cssjs/76FxTbJFtwCN8xB3-k_A_A.c.js"></script> </body> </html>