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{"work":{"id":13230080,"created_at":"2015-06-23T21:09:49.925-07:00","from_world_paper_id":137972181,"updated_at":"2024-11-11T18:19:06.952-08:00","_data":{"grobid_abstract":"Development of chemotherapy resistance and evasion from apoptosis in osteosarcoma, a primary malignant bone tumor, is often correlated with constitutive nuclear factor-κB (NF-κB) activation. Here, we investigated the ability of a polyphenolic fraction of green tea (GTP) that has been shown to have antitumor effects on various malignant cell lines to inhibit growth and induce apoptosis in human osteosarcoma SAOS-2 cells. Treatment of SAOS-2 cells with GTP (20-60 μg/ml) resulted in reduced cell proliferation and induction of apoptosis, which correlated with decreased nuclear DNA binding of NF-κB/p65 and lowering of NF-κB/p65 and p50 levels in the cytoplasm and nucleus. GTP treatment of cells reduced IκB-α phosphorylation but had no effect on its protein expression. Furthermore, GTP treatment resulted in the inhibition of IKK-α and IKK-β, the upstream kinases that phosphorylate IκB-α. The increase in apoptosis in SAOS-2 cells was accompanied with decrease in the protein expression of Bcl-2 and concomitant increase in the levels of Bax. GTP treatment of SAOS-2 cells also resulted in significant activation of caspases as was evident by increased levels of cleaved caspase-3 and caspase-8 in these cells. Treatment of SAOS-2 cells with a specific caspase-3 inhibitor Ac-Asp-Glu-Val-Asp-CHO (Ac-DEVD-CHO) and general caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp (OMe)-fluoromethyl ketone (Z-VAD-FMK) rescued SAOS-2 cells from GTP-induced apoptosis. Taken together, these results indicate that GTP is a candidate therapeutic for osteosarcoma that mediates its antiproliferative and apoptotic effects via activation of caspases and inhibition of NF-κB.","publication_date":"2006,,","publication_name":"Toxicology and Applied Pharmacology","grobid_abstract_attachment_id":"45568959"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [32484048]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 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Until now, no studies have looked at the role of GA in osteosarcoma. In this study, we observed the effects of GA on the growth and apoptosis of osteosarcoma cells in vitro. We found that GA treatment inhibits the proliferation of osteosarcoma cells by inducing cell cycle arrest. Moreover, we found that GA induces apoptosis in MG63, HOS and U2OS cells. Furthermore, we showed that GA treatment elevates the Bax/Bcl-2 ratio. GA mediated the G0/G1 phase arrest in U2OS cells; this arrest was associated with a decrease in phospho-GSK3-β (Ser9) and the expression of cyclin D1. Similarly, in MG63 cells, GA mediated G2/M cell cycle arrest, which was associated with a decrease in phospho-cdc2 (Thr 161) and cdc25B. 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href="https://www.academia.edu/31993073/Gambogic_acid_inhibits_the_growth_of_osteosarcoma_cells_in_vitro_by_inducing_apoptosis_and_cell_cycle_arrest"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="13230054" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13230054/Essential_role_of_caspases_in_epigallocatechin_3_gallate_mediated_inhibition_of_nuclear_factor_kappaB_and_induction_of_apoptosis">Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32484048" href="https://independent.academia.edu/SanjayGupta94">Sanjay Gupta</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oncogene, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis","attachmentId":45568940,"attachmentType":"pdf","work_url":"https://www.academia.edu/13230054/Essential_role_of_caspases_in_epigallocatechin_3_gallate_mediated_inhibition_of_nuclear_factor_kappaB_and_induction_of_apoptosis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13230054/Essential_role_of_caspases_in_epigallocatechin_3_gallate_mediated_inhibition_of_nuclear_factor_kappaB_and_induction_of_apoptosis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="63870159" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63870159/Sensitization_of_osteosarcoma_cells_to_apoptosis_by_oncostatin_M_depends_on_STAT5_and_p53">Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42663025" href="https://independent.academia.edu/PhilippeJuin">Philippe Juin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oncogene, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53","attachmentId":76150186,"attachmentType":"pdf","work_url":"https://www.academia.edu/63870159/Sensitization_of_osteosarcoma_cells_to_apoptosis_by_oncostatin_M_depends_on_STAT5_and_p53","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63870159/Sensitization_of_osteosarcoma_cells_to_apoptosis_by_oncostatin_M_depends_on_STAT5_and_p53"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="27540368" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27540368/Antagonism_of_inhibitor_of_apoptosis_proteins_increases_bone_metastasis_via_unexpected_osteoclast_activation">Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32904825" href="https://independent.academia.edu/RobertMach">Robert Mach</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer discovery, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Inhibitor of apoptosis (IAP) proteins play a central role in many types of cancer, and IAP antagonists are in development as anticancer agents. IAP antagonists cause apoptosis in many cells, but they also activate alternative NF-κB signaling through NF-κB-inducing kinase (NIK), which regulates osteoclasts. In bone metastasis, a positive feedback loop between tumors and osteoclasts promotes tumor growth and osteolysis. We therefore tested the effect of IAP antagonists on the bone microenvironment for metastasis. In both drug-sensitive and drug-resistant tumors, growth in bone was favored, as compared with other sites during IAP antagonist treatment. These drugs also caused osteoporosis and increased osteoclastogenesis, mediated by NIK, and enhanced tumor-associated osteolysis. Cotreatment with zoledronic acid, a potent osteoclast inhibitor, reduced IAP antagonist-enhanced tumor growth in bone and osteolysis. Thus, IAP antagonist-based cancer treatment may be compromised by osteoporos...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation","attachmentId":47793862,"attachmentType":"pdf","work_url":"https://www.academia.edu/27540368/Antagonism_of_inhibitor_of_apoptosis_proteins_increases_bone_metastasis_via_unexpected_osteoclast_activation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27540368/Antagonism_of_inhibitor_of_apoptosis_proteins_increases_bone_metastasis_via_unexpected_osteoclast_activation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="68574998" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/68574998/Caffeic_Acid_Induced_Apoptosis_in_MG63_Osteosarcoma_Cells_Through_Activation_of_Caspases">Caffeic Acid Induced Apoptosis in MG63 Osteosarcoma Cells Through Activation of Caspases</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65245642" href="https://independent.academia.edu/FerrySandra1">Ferry Sandra</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular and Cellular Biomedical Sciences, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Caffeic acid has been reported that when it is combined with all-trans retinoic acid, it can inhibit proliferation activity of SaOS-2 or OSA-01 cells. In addition, caffeic acid merely could reduce cell viability of SaOS-2 cells. However, there is not any study in caffeic acid&#39;s possible effect to induce apoptosis in osteosarcoma cell.Materials and Methods: MG-63 cells were cultured in Dulbecco’s Modified Eagle Medium containing 10% fetal bovine serum. Cells were treated with various concentrations of caffeic acid. Apoptosis were analyzed with Sub-G1 assay and activation of caspase-8, -9, and -3 were analyzed with immunoblotting. Caffeic acid-induced percentage of apoptotic cells and cleaved-8, -9, -3 were then statistically analyzed.Results: Sub-G1 results showed that caffeic acid significantly induced apoptosis in MG-63 osteosarcoma cells in concentration dependent manner. Immunoblotting results showed that caffeic acid induced cleavage of caspase-8, -9 and -3. Clea...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Caffeic Acid Induced Apoptosis in MG63 Osteosarcoma Cells Through Activation of Caspases","attachmentId":79004013,"attachmentType":"pdf","work_url":"https://www.academia.edu/68574998/Caffeic_Acid_Induced_Apoptosis_in_MG63_Osteosarcoma_Cells_Through_Activation_of_Caspases","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/68574998/Caffeic_Acid_Induced_Apoptosis_in_MG63_Osteosarcoma_Cells_Through_Activation_of_Caspases"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="57698278" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57698278/The_secreted_protein_acidic_and_rich_in_cysteine_is_a_critical_mediator_of_cell_death_program_induced_by_WIN_TRAIL_combined_treatment_in_osteosarcoma_cells">The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="112912383" href="https://independent.academia.edu/AntoniettaNotaro">Antonietta Notaro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Oncology, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells","attachmentId":72472008,"attachmentType":"pdf","work_url":"https://www.academia.edu/57698278/The_secreted_protein_acidic_and_rich_in_cysteine_is_a_critical_mediator_of_cell_death_program_induced_by_WIN_TRAIL_combined_treatment_in_osteosarcoma_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/57698278/The_secreted_protein_acidic_and_rich_in_cysteine_is_a_critical_mediator_of_cell_death_program_induced_by_WIN_TRAIL_combined_treatment_in_osteosarcoma_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":45568959,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":45568959,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_45568959" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="108098156" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/108098156/Apoptosis_A_Target_for_Anticancer_Therapy">Apoptosis: A Target for Anticancer Therapy</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58883753" href="https://independent.academia.edu/AmareshwarSingh">Amareshwar Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Molecular Sciences, 2018</p><div class="ds-related-work--ctas"><button 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="72606159" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72606159/Apoptosis_of_human_fibrosarcoma_HT_1080_cells_by_epigallocatechin_3_O_gallate_via_induction_of_p53_and_caspases_as_well_as_suppression_of_Bcl_2_and_phosphorylated_nuclear_factor_%CE%BAB">Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8229655" href="https://independent.academia.edu/DongWookHan">Dong-Wook Han</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Apoptosis, 2011</p><div 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href="https://uma.academia.edu/LeonorSantosRuiz">Leonor Santos-Ruiz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecules</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy","attachmentId":90953651,"attachmentType":"pdf","work_url":"https://www.academia.edu/86520629/Traditional_Medicinal_Plants_as_a_Source_of_Inspiration_for_Osteosarcoma_Therapy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/86520629/Traditional_Medicinal_Plants_as_a_Source_of_Inspiration_for_Osteosarcoma_Therapy"><span 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="28708145" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28708145/Interferon_sensitizes_osteosarcoma_cells_to_fas_induced_apoptosis_by_up_regulating_fas_receptors_and_caspase_8">Interferon-? sensitizes osteosarcoma cells to fas-induced apoptosis by up-regulating fas receptors and caspase-8</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32982621" href="https://independent.academia.edu/MariaGlibetic">Maria Glibetic</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatric Blood & Cancer, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="99622595" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99622595/_content_Anticancer_effects_of_10_hydroxycamptothecin_induce_apoptosis_of_human_osteosarcoma_through_activating_caspase_3_p53_and_cytochromepathways_i_content_c_">{"__content__"=>"Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochromepathways.", "i"=>{"__content__"=>"c"}}</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="264459676" href="https://independent.academia.edu/CHENYUJIE2">CHEN YU JIE</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oncology letters, 2018</p><div 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