CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>Lanosterol 14 alpha-demethylase - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"4aff86bb-15b1-4fad-9eba-705f31d6a130","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Lanosterol_14_alpha-demethylase","wgTitle":"Lanosterol 14 alpha-demethylase","wgCurRevisionId":1189981848,"wgRevisionId":1189981848,"wgArticleId":10906045,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["Articles with short description","Short description matches Wikidata","Protein pages needing a picture","Human gene pages with Wikidata item","Genes on human chromosome 7","EC 1.14.14","Cytochrome P450","NADPH-dependent enzymes","Enzymes of known structure"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"Lanosterol_14_alpha-demethylase","wgRelevantArticleId":10906045, "wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgRedirectedFrom":"Lanosterol_14α-demethylase","wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}},"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":10000,"wgInternalRedirectTargetUrl":"/wiki/Lanosterol_14_alpha-demethylase","wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q17912234", "wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["mediawiki.action.view.redirect","ext.cite.ux-enhancements","mediawiki.page.media","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc" ,"skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/1200px-Ideogram_human_chromosome_7.svg.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="478"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/800px-Ideogram_human_chromosome_7.svg.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="319"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/640px-Ideogram_human_chromosome_7.svg.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="255"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Lanosterol 14 alpha-demethylase - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/Lanosterol_14_alpha-demethylase"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/Lanosterol_14_alpha-demethylase"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Lanosterol_14_alpha-demethylase rootpage-Lanosterol_14_alpha-demethylase skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Main menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z"><span>Main page</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia"><span>Contents</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events"><span>Current events</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x"><span>Random article</span></a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works"><span>About Wikipedia</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia"><span>Contact us</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia"><span>Help</span></a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia"><span>Learn to edit</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors"><span>Community portal</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r"><span>Recent changes</span></a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia"><span>Upload file</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Appearance</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=Lanosterol+14+alpha-demethylase" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=Lanosterol+14+alpha-demethylase" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class=""><span>Log in</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Personal tools</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en"><span>Donate</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=Lanosterol+14+alpha-demethylase" title="You are encouraged to create an account and log in; however, it is not mandatory"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Create account</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=Lanosterol+14+alpha-demethylase" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Evolution" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Evolution"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Evolution</span> </div> </a> <ul id="toc-Evolution-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Structure" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Structure</span> </div> </a> <ul id="toc-Structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mechanism" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mechanism"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Mechanism</span> </div> </a> <ul id="toc-Mechanism-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Lanosterol 14 alpha-demethylase</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 4 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-4" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">4 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Lanosterin-Demethylase" title="Lanosterin-Demethylase – German" lang="de" hreflang="de" data-title="Lanosterin-Demethylase" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Lanosterol-14%CE%B1-demetyl%C3%A1za" title="Lanosterol-14α-demetyláza – Slovak" lang="sk" hreflang="sk" data-title="Lanosterol-14α-demetyláza" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/CYP51A1" title="CYP51A1 – Ukrainian" lang="uk" hreflang="uk" data-title="CYP51A1" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/CYP51A1" title="CYP51A1 – Chinese" lang="zh" hreflang="zh" data-title="CYP51A1" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q17912234#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Lanosterol_14_alpha-demethylase" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Lanosterol_14_alpha-demethylase" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">English</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Lanosterol_14_alpha-demethylase"><span>Read</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=history" title="Past revisions of this page [h]" accesskey="h"><span>View history</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Tools</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Lanosterol_14_alpha-demethylase"><span>Read</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=history"><span>View history</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/Lanosterol_14_alpha-demethylase" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/Lanosterol_14_alpha-demethylase" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages" title="A list of all special pages [q]" accesskey="q"><span>Special pages</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&oldid=1189981848" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=Lanosterol_14_alpha-demethylase&id=1189981848&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FLanosterol_14_alpha-demethylase"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FLanosterol_14_alpha-demethylase"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Lanosterol_14_alpha-demethylase&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q17912234" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"><span class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=Lanosterol_14%CE%B1-demethylase&redirect=no" class="mw-redirect" title="Lanosterol 14α-demethylase">Lanosterol 14α-demethylase</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CYP51A1</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q8K0C4%20or%20Q16850">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q8K0C4,Q16850">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3JUS">3JUS</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3JUV">3JUV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3LD6">3LD6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4UHI">4UHI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4UHL">4UHL</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/2649">CYP51A1</a></span>, CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1, cytochrome P450 family 51 subfamily A member 1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/601637">601637</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:106040">106040</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=55488">55488</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP51A1">CYP51A1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000001630">CYP51A1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (human)"><img alt="Chromosome 7 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/450px-Ideogram_human_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/600px-Ideogram_human_chromosome_7.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_7_(human)" class="mw-redirect" title="Chromosome 7 (human)">Chromosome 7 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_7_ideogram.svg" class="mw-file-description" title="Chromosome 7 (human)"><img alt="Chromosome 7 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/300px-Human_chromosome_7_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/450px-Human_chromosome_7_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/600px-Human_chromosome_7_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 164.62361376283px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CYP51A1"><img alt="Genomic location for CYP51A1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 170.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CYP51A1"><img alt="Genomic location for CYP51A1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">7q21.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">92,084,987 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">92,134,803 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (mouse)"><img alt="Chromosome 5 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/390px-Ideogram_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/520px-Ideogram_house_mouse_chromosome_5.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 5 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (mouse)"><img alt="Chromosome 5 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/300px-Ideogram_of_house_mouse_chromosome_5.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/450px-Ideogram_of_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/600px-Ideogram_of_house_mouse_chromosome_5.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 2.6256881052329px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CYP51A1"><img alt="Genomic location for CYP51A1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 8.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CYP51A1"><img alt="Genomic location for CYP51A1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">5 A1|5 2.3 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">4,131,145 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">4,154,746 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000001630">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">corpus callosum</li><br /><li style="line-height: 137%;">C1 segment</li><br /><li style="line-height: 137%;">right testis</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">left testis</li><br /><li style="line-height: 137%;">liver</li><br /><li style="line-height: 137%;">superior frontal gyrus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000001467">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">genital tubercle</li><br /><li style="line-height: 137%;">proximal tubule</li><br /><li style="line-height: 137%;">right kidney</li><br /><li style="line-height: 137%;">skin of external ear</li><br /><li style="line-height: 137%;">superior cervical ganglion</li><br /><li style="line-height: 137%;">human kidney</li><br /><li style="line-height: 137%;">neural tube</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">sciatic nerve</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000001630">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005506">iron ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004497">monooxygenase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0020037">heme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016705">oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016491">oxidoreductase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008398">sterol 14-demethylase activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031090">organelle membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005789">endoplasmic reticulum membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043231">intracellular membrane-bounded organelle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005783">endoplasmic reticulum</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008202">steroid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016126">sterol biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006629">lipid metabolism</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008203">cholesterol metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033488">cholesterol biosynthetic process via 24,25-dihydrolanosterol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016125">sterol metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006695">cholesterol biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006694">steroid biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070988">demethylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045540">regulation of cholesterol biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042177">negative regulation of protein catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050709">negative regulation of protein secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900222">negative regulation of amyloid-beta clearance</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1595&rn=1">1595</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13121&rn=1">13121</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000001630;db=core">ENSG00000001630</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000001467;db=core">ENSMUSG00000001467</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q16850">Q16850</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8K0C4">Q8K0C4</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001146152">NM_001146152</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000786">NM_000786</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_020010">NM_020010</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000777">NP_000777</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001139624">NP_001139624</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_064394">NP_064394</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr7:92084987-92134803">Chr 7: 92.08 – 92.13 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr5:4131145-4154746">Chr 5: 4.13 – 4.15 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q17912234" class="extiw" title="d:Q17912234">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18248645" class="extiw" title="d:Q18248645">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Cytochrome P450, Family 51, Subfamily A, Polypeptide 1</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">CYP51A1</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">CYP51, P45014DM</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=1595&rn=1">1595</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2649">2649</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/601637">601637</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NM_000786">NM_000786</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q16850">Q16850</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+1.14.14.154">1.14.14.154</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_7_(human)" class="mw-redirect" title="Chromosome 7 (human)">Chr. 7</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=7q21.2">q21.2-21.3</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q16850">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q16850">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Lanosterol_skeletal.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/Lanosterol_skeletal.svg/220px-Lanosterol_skeletal.svg.png" decoding="async" width="220" height="119" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/16/Lanosterol_skeletal.svg/330px-Lanosterol_skeletal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/16/Lanosterol_skeletal.svg/440px-Lanosterol_skeletal.svg.png 2x" data-file-width="1968" data-file-height="1061" /></a><figcaption>Lanosterol</figcaption></figure> <p><b>Lanosterol 14α-demethylase</b> (<b>CYP51A1</b>) is the animal version of <a href="/wiki/Sterol_14-demethylase" title="Sterol 14-demethylase">a cytochrome P450 enzyme</a> that is involved in the conversion of <a href="/wiki/Lanosterol" title="Lanosterol">lanosterol</a> to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> <a href="/wiki/Isoenzyme" class="mw-redirect" title="Isoenzyme">isoenzymes</a> are a conserved group of <a href="/wiki/Protein" title="Protein">proteins</a> that serve as key players in the <a href="/wiki/Metabolism" title="Metabolism">metabolism</a> of <a href="/wiki/Organic_compound" title="Organic compound">organic substances</a> and the <a href="/wiki/Biosynthesis" title="Biosynthesis">biosynthesis</a> of important <a href="/wiki/Steroid" title="Steroid">steroids</a>, <a href="/wiki/Lipid" title="Lipid">lipids</a>, and <a href="/wiki/Vitamin" title="Vitamin">vitamins</a> in <a href="/wiki/Eukaryotes" class="mw-redirect" title="Eukaryotes">eukaryotes</a>.<sup id="cite_ref-Lepesheva_2007_6-0" class="reference"><a href="#cite_note-Lepesheva_2007-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> As a member of this family, lanosterol 14α-demethylase is responsible for an essential step in the biosynthesis of <a href="/wiki/Sterols" class="mw-redirect" title="Sterols">sterols</a>. In particular, this protein catalyzes the removal of the C-14α-<a href="/wiki/Methyl_group" title="Methyl group">methyl group</a> from <a href="/wiki/Lanosterol" title="Lanosterol">lanosterol</a>.<sup id="cite_ref-Lepesheva_2007_6-1" class="reference"><a href="#cite_note-Lepesheva_2007-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> This demethylation step is regarded as the initial checkpoint in the transformation of <a href="/wiki/Lanosterol" title="Lanosterol">lanosterol</a> to other <a href="/wiki/Sterols" class="mw-redirect" title="Sterols">sterols</a> that are widely used within the cell.<sup id="cite_ref-Lepesheva_2007_6-2" class="reference"><a href="#cite_note-Lepesheva_2007-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Evolution">Evolution</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=1" title="Edit section: Evolution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/CYP51" class="mw-redirect" title="CYP51">CYP51</a></div> <p>The structural and functional properties of the <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> superfamily have been subject to extensive diversification over the course of evolution.<sup id="cite_ref-Becher_2012_7-0" class="reference"><a href="#cite_note-Becher_2012-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Recent estimates indicate that there are currently 10 <a href="/wiki/Class_(biology)" title="Class (biology)">classes</a> and 267 <a href="/wiki/Family_(biology)" title="Family (biology)">families</a> of CYP proteins.<sup id="cite_ref-Hannemann_2007_8-0" class="reference"><a href="#cite_note-Hannemann_2007-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> It is believed that 14α-demethylase or CYP51 diverged early in the cytochrome's <a href="/wiki/Evolutionary_history" class="mw-redirect" title="Evolutionary history">evolutionary history</a> and has preserved its function ever since; namely, the removal of the 14α-methyl group from sterol <a href="/wiki/Substrate_(biochemistry)" class="mw-redirect" title="Substrate (biochemistry)">substrates</a>.<sup id="cite_ref-Becher_2012_7-1" class="reference"><a href="#cite_note-Becher_2012-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Although CYP51's mode of action has been well <a href="/wiki/Conserved_sequence" title="Conserved sequence">conserved</a>, the protein's sequence varies considerably between biological kingdoms.<sup id="cite_ref-Lepesheva_2004_9-0" class="reference"><a href="#cite_note-Lepesheva_2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> CYP51 sequence comparisons between kingdoms reveal only a 22-30% similarity in amino acid composition.<sup id="cite_ref-Lepesheva_2011_10-0" class="reference"><a href="#cite_note-Lepesheva_2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=2" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Structure_of_lanosterol_14_%CE%B1-demethylase_(CYP51).png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Structure_of_lanosterol_14_%CE%B1-demethylase_%28CYP51%29.png/220px-Structure_of_lanosterol_14_%CE%B1-demethylase_%28CYP51%29.png" decoding="async" width="220" height="206" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Structure_of_lanosterol_14_%CE%B1-demethylase_%28CYP51%29.png/330px-Structure_of_lanosterol_14_%CE%B1-demethylase_%28CYP51%29.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Structure_of_lanosterol_14_%CE%B1-demethylase_%28CYP51%29.png/440px-Structure_of_lanosterol_14_%CE%B1-demethylase_%28CYP51%29.png 2x" data-file-width="1089" data-file-height="1022" /></a><figcaption>Structure of lanosterol 14α-demethylase (CYP51), as identified by Podust et al.</figcaption></figure> <p>Although the structure of 14α-demethylase may vary substantially from one organism to the next, <a href="/wiki/Sequence_alignment" title="Sequence alignment">sequence alignment</a> analysis reveals that there are six regions in the protein that are highly <a href="/wiki/Conserved_sequence" title="Conserved sequence">conserved</a> in <a href="/wiki/Eukaryotes" class="mw-redirect" title="Eukaryotes">eukaryotes</a>.<sup id="cite_ref-Lepesheva_2011_10-1" class="reference"><a href="#cite_note-Lepesheva_2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> These include residues in the B' helix, B'/C loop, C helix, I helix, K/β1-4 loop, and β-strand 1-4 that are responsible for forming the surface of the substrate binding cavity.<sup id="cite_ref-Becher_2012_7-2" class="reference"><a href="#cite_note-Becher_2012-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Homology_modeling" title="Homology modeling">Homology modeling</a> reveals that <a href="/wiki/Substrate_(biochemistry)" class="mw-redirect" title="Substrate (biochemistry)">substrates</a> migrate from the surface of the protein to the enzyme's buried <a href="/wiki/Active_site" title="Active site">active site</a> through a channel that is formed in part by the A' <a href="/wiki/Alpha_helix" title="Alpha helix">alpha helix</a> and the β4 loop.<sup id="cite_ref-Hargrove_2011_11-0" class="reference"><a href="#cite_note-Hargrove_2011-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Podust_2007_12-0" class="reference"><a href="#cite_note-Podust_2007-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Finally, the <a href="/wiki/Active_site" title="Active site">active site</a> contains a <a href="/wiki/Heme" title="Heme">heme</a> <a href="/wiki/Prosthetic_group" title="Prosthetic group">prosthetic group</a> in which the iron is tethered to the sulfur atom on a conserved cysteine residue.<sup id="cite_ref-Lepesheva_2011_10-2" class="reference"><a href="#cite_note-Lepesheva_2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> This group also binds diatomic oxygen at the sixth coordination site, which is eventually incorporated onto the substrate.<sup id="cite_ref-Lepesheva_2011_10-3" class="reference"><a href="#cite_note-Lepesheva_2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mechanism">Mechanism</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=3" title="Edit section: Mechanism"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Lanosterol_Demethylation_Pathway.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6a/Lanosterol_Demethylation_Pathway.png/220px-Lanosterol_Demethylation_Pathway.png" decoding="async" width="220" height="176" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6a/Lanosterol_Demethylation_Pathway.png/330px-Lanosterol_Demethylation_Pathway.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6a/Lanosterol_Demethylation_Pathway.png/440px-Lanosterol_Demethylation_Pathway.png 2x" data-file-width="4301" data-file-height="3441" /></a><figcaption>Three-step demethylation of lanosterol, mediated by lanosterol 14α-demethylase.</figcaption></figure> <p>The enzyme-catalyzed <a href="/wiki/Demethylation" title="Demethylation">demethylation</a> of <a href="/wiki/Lanosterol" title="Lanosterol">lanosterol</a> is believed to occur in three steps, each of which requires one molecule of diatomic oxygen and one molecule of <a href="/wiki/NADPH" class="mw-redirect" title="NADPH">NADPH</a> (or some other <a href="/wiki/Reducing_equivalent" class="mw-redirect" title="Reducing equivalent">reducing equivalent</a>).<sup id="cite_ref-Vanden_Bossche_1998_13-0" class="reference"><a href="#cite_note-Vanden_Bossche_1998-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> During the first two steps, the 14α-methyl group undergoes typical <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome</a> monooxygenation in which one oxygen atom is incorporated by the substrate and the other is reduced to water, resulting in the sterol's conversion to a carboxyalcohol and then a carboxyaldehyde.<sup id="cite_ref-Lepesheva_2011_10-4" class="reference"><a href="#cite_note-Lepesheva_2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The aldehyde then departs as <a href="/wiki/Formic_acid" title="Formic acid">formic acid</a> and a double bond is simultaneously introduced to yield the demethylated product.<sup id="cite_ref-Lepesheva_2011_10-5" class="reference"><a href="#cite_note-Lepesheva_2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=4" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Steroidogenic_enzyme" title="Steroidogenic enzyme">Steroidogenic enzyme</a></li> <li><a href="/wiki/Azole_antifungals" class="mw-redirect" title="Azole antifungals">Azole antifungals</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000001630">GRCh38: Ensembl release 89: ENSG00000001630</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000001467">GRCm38: Ensembl release 89: ENSMUSG00000001467</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1595">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D1595&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=13121">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D13121&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.hmdb.ca/metabolites/HMDB01023">"Metabocard for 4,4-Dimethylcholesta-8,14,24-trienol (HMDB01023)"</a>. <i>Human Metabolome Database</i>. February 2014.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Human+Metabolome+Database&rft.atitle=Metabocard+for+4%2C4-Dimethylcholesta-8%2C14%2C24-trienol+%28HMDB01023%29&rft.date=2014-02&rft_id=http%3A%2F%2Fwww.hmdb.ca%2Fmetabolites%2FHMDB01023&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Lepesheva_2007-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-Lepesheva_2007_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Lepesheva_2007_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Lepesheva_2007_6-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLepeshevaWaterman2007" class="citation journal cs1">Lepesheva GI, Waterman MR (March 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2324071">"Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms"</a>. <i>Biochimica et Biophysica Acta (BBA) - General Subjects</i>. <b>1770</b> (3): 467–77. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbagen.2006.07.018">10.1016/j.bbagen.2006.07.018</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2324071">2324071</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16963187">16963187</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta+%28BBA%29+-+General+Subjects&rft.atitle=Sterol+14alpha-demethylase+cytochrome+P450+%28CYP51%29%2C+a+P450+in+all+biological+kingdoms&rft.volume=1770&rft.issue=3&rft.pages=467-77&rft.date=2007-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2324071%23id-name%3DPMC&rft_id=info%3Apmid%2F16963187&rft_id=info%3Adoi%2F10.1016%2Fj.bbagen.2006.07.018&rft.aulast=Lepesheva&rft.aufirst=GI&rft.au=Waterman%2C+MR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2324071&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Becher_2012-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-Becher_2012_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Becher_2012_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Becher_2012_7-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBecherWirsel2012" class="citation journal cs1">Becher R, Wirsel SG (August 2012). "Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens". <i>Applied Microbiology and Biotechnology</i>. <b>95</b> (4): 825–40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00253-012-4195-9">10.1007/s00253-012-4195-9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22684327">22684327</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:17688962">17688962</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Fungal+cytochrome+P450+sterol+14%CE%B1-demethylase+%28CYP51%29+and+azole+resistance+in+plant+and+human+pathogens&rft.volume=95&rft.issue=4&rft.pages=825-40&rft.date=2012-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A17688962%23id-name%3DS2CID&rft_id=info%3Apmid%2F22684327&rft_id=info%3Adoi%2F10.1007%2Fs00253-012-4195-9&rft.aulast=Becher&rft.aufirst=R&rft.au=Wirsel%2C+SG&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Hannemann_2007-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-Hannemann_2007_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHannemannBichetEwenBernhardt2007" class="citation journal cs1">Hannemann F, Bichet A, Ewen KM, Bernhardt R (March 2007). "Cytochrome P450 systems--biological variations of electron transport chains". <i>Biochimica et Biophysica Acta (BBA) - General Subjects</i>. <b>1770</b> (3): 330–44. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbagen.2006.07.017">10.1016/j.bbagen.2006.07.017</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16978787">16978787</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta+%28BBA%29+-+General+Subjects&rft.atitle=Cytochrome+P450+systems--biological+variations+of+electron+transport+chains&rft.volume=1770&rft.issue=3&rft.pages=330-44&rft.date=2007-03&rft_id=info%3Adoi%2F10.1016%2Fj.bbagen.2006.07.017&rft_id=info%3Apmid%2F16978787&rft.aulast=Hannemann&rft.aufirst=F&rft.au=Bichet%2C+A&rft.au=Ewen%2C+KM&rft.au=Bernhardt%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Lepesheva_2004-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-Lepesheva_2004_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLepeshevaWaterman2004" class="citation journal cs1">Lepesheva GI, Waterman MR (February 2004). "CYP51--the omnipotent P450". <i>Molecular and Cellular Endocrinology</i>. <b>215</b> (1–2): 165–70. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.mce.2003.11.016">10.1016/j.mce.2003.11.016</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15026190">15026190</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:22489096">22489096</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Endocrinology&rft.atitle=CYP51--the+omnipotent+P450&rft.volume=215&rft.issue=1%E2%80%932&rft.pages=165-70&rft.date=2004-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A22489096%23id-name%3DS2CID&rft_id=info%3Apmid%2F15026190&rft_id=info%3Adoi%2F10.1016%2Fj.mce.2003.11.016&rft.aulast=Lepesheva&rft.aufirst=GI&rft.au=Waterman%2C+MR&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Lepesheva_2011-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-Lepesheva_2011_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Lepesheva_2011_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Lepesheva_2011_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Lepesheva_2011_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Lepesheva_2011_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Lepesheva_2011_10-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLepeshevaWaterman2011" class="citation journal cs1">Lepesheva GI, Waterman MR (January 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962772">"Structural basis for conservation in the CYP51 family"</a>. <i>Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics</i>. <b>1814</b> (1): 88–93. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbapap.2010.06.006">10.1016/j.bbapap.2010.06.006</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962772">2962772</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20547249">20547249</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta+%28BBA%29+-+Proteins+and+Proteomics&rft.atitle=Structural+basis+for+conservation+in+the+CYP51+family&rft.volume=1814&rft.issue=1&rft.pages=88-93&rft.date=2011-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2962772%23id-name%3DPMC&rft_id=info%3Apmid%2F20547249&rft_id=info%3Adoi%2F10.1016%2Fj.bbapap.2010.06.006&rft.aulast=Lepesheva&rft.aufirst=GI&rft.au=Waterman%2C+MR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2962772&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Hargrove_2011-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-Hargrove_2011_11-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHargroveWawrzakLiuNes2011" class="citation journal cs1">Hargrove TY, Wawrzak Z, Liu J, Nes WD, Waterman MR, Lepesheva GI (July 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143644">"Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum"</a>. <i>The Journal of Biological Chemistry</i>. <b>286</b> (30): 26838–48. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M111.237099">10.1074/jbc.M111.237099</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143644">3143644</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21632531">21632531</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Substrate+preferences+and+catalytic+parameters+determined+by+structural+characteristics+of+sterol+14alpha-demethylase+%28CYP51%29+from+Leishmania+infantum&rft.volume=286&rft.issue=30&rft.pages=26838-48&rft.date=2011-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3143644%23id-name%3DPMC&rft_id=info%3Apmid%2F21632531&rft_id=info%3Adoi%2F10.1074%2Fjbc.M111.237099&rft.aulast=Hargrove&rft.aufirst=TY&rft.au=Wawrzak%2C+Z&rft.au=Liu%2C+J&rft.au=Nes%2C+WD&rft.au=Waterman%2C+MR&rft.au=Lepesheva%2C+GI&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3143644&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Podust_2007-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-Podust_2007_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPodustvon_KriesEddineKim2007" class="citation journal cs1">Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, et al. (November 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151439">"Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography"</a>. <i>Antimicrobial Agents and Chemotherapy</i>. <b>51</b> (11): 3915–23. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FAAC.00311-07">10.1128/AAC.00311-07</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151439">2151439</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17846131">17846131</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Small-molecule+scaffolds+for+CYP51+inhibitors+identified+by+high-throughput+screening+and+defined+by+X-ray+crystallography&rft.volume=51&rft.issue=11&rft.pages=3915-23&rft.date=2007-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2151439%23id-name%3DPMC&rft_id=info%3Apmid%2F17846131&rft_id=info%3Adoi%2F10.1128%2FAAC.00311-07&rft.aulast=Podust&rft.aufirst=LM&rft.au=von+Kries%2C+JP&rft.au=Eddine%2C+AN&rft.au=Kim%2C+Y&rft.au=Yermalitskaya%2C+LV&rft.au=Kuehne%2C+R&rft.au=Ouellet%2C+H&rft.au=Warrier%2C+T&rft.au=Altek%C3%B6ster%2C+M&rft.au=Lee%2C+JS&rft.au=Rademann%2C+J&rft.au=Oschkinat%2C+H&rft.au=Kaufmann%2C+SH&rft.au=Waterman%2C+MR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2151439&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> <li id="cite_note-Vanden_Bossche_1998-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-Vanden_Bossche_1998_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVanden_BosscheKoymans1998" class="citation journal cs1">Vanden Bossche H, Koymans L (1998). "Cytochromes P450 in fungi". <i>Mycoses</i>. <b>41</b> (Suppl 1): 32–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1439-0507.1998.tb00581.x">10.1111/j.1439-0507.1998.tb00581.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9717384">9717384</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:83821510">83821510</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mycoses&rft.atitle=Cytochromes+P450+in+fungi&rft.volume=41&rft.issue=Suppl+1&rft.pages=32-8&rft.date=1998&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A83821510%23id-name%3DS2CID&rft_id=info%3Apmid%2F9717384&rft_id=info%3Adoi%2F10.1111%2Fj.1439-0507.1998.tb00581.x&rft.aulast=Vanden+Bossche&rft.aufirst=H&rft.au=Koymans%2C+L&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=6" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBakKahnOlsenHalkier1997" class="citation journal cs1">Bak S, Kahn RA, Olsen CE, Halkier BA (February 1997). <a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1365-313X.1997.11020191.x">"Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals"</a>. <i>The Plant Journal</i>. <b>11</b> (2): 191–201. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1365-313X.1997.11020191.x">10.1046/j.1365-313X.1997.11020191.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9076987">9076987</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Plant+Journal&rft.atitle=Cloning+and+expression+in+Escherichia+coli+of+the+obtusifoliol+14+alpha-demethylase+of+Sorghum+bicolor+%28L.%29+Moench%2C+a+cytochrome+P450+orthologous+to+the+sterol+14+alpha-demethylases+%28CYP51%29+from+fungi+and+mammals&rft.volume=11&rft.issue=2&rft.pages=191-201&rft.date=1997-02&rft_id=info%3Adoi%2F10.1046%2Fj.1365-313X.1997.11020191.x&rft_id=info%3Apmid%2F9076987&rft.aulast=Bak&rft.aufirst=S&rft.au=Kahn%2C+RA&rft.au=Olsen%2C+CE&rft.au=Halkier%2C+BA&rft_id=https%3A%2F%2Fdoi.org%2F10.1046%252Fj.1365-313X.1997.11020191.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAoyamaYoshida1991" class="citation journal cs1">Aoyama Y, Yoshida Y (August 1991). "Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol". <i>Biochemical and Biophysical Research Communications</i>. <b>178</b> (3): 1064–71. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0006-291X%2891%2991000-3">10.1016/0006-291X(91)91000-3</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1872829">1872829</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Different+substrate+specificities+of+lanosterol+14a-demethylase+%28P-45014DM%29+of+Saccharomyces+cerevisiae+and+rat+liver+for+24-methylene-24%2C25-dihydrolanosterol+and+24%2C25-dihydrolanosterol&rft.volume=178&rft.issue=3&rft.pages=1064-71&rft.date=1991-08&rft_id=info%3Adoi%2F10.1016%2F0006-291X%2891%2991000-3&rft_id=info%3Apmid%2F1872829&rft.aulast=Aoyama&rft.aufirst=Y&rft.au=Yoshida%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAoyamaYoshida1992" class="citation journal cs1">Aoyama Y, Yoshida Y (March 1992). "The 4 beta-methyl group of substrate does not affect the activity of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast: difference between the substrate recognition by yeast and plant sterol 14 alpha-demethylases". <i>Biochemical and Biophysical Research Communications</i>. <b>183</b> (3): 1266–72. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0006-291X%2805%2980327-4">10.1016/S0006-291X(05)80327-4</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1567403">1567403</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=The+4+beta-methyl+group+of+substrate+does+not+affect+the+activity+of+lanosterol+14+alpha-demethylase+%28P-450%2814%29DM%29+of+yeast%3A+difference+between+the+substrate+recognition+by+yeast+and+plant+sterol+14+alpha-demethylases&rft.volume=183&rft.issue=3&rft.pages=1266-72&rft.date=1992-03&rft_id=info%3Adoi%2F10.1016%2FS0006-291X%2805%2980327-4&rft_id=info%3Apmid%2F1567403&rft.aulast=Aoyama&rft.aufirst=Y&rft.au=Yoshida%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAlexanderAkhtarBoarMcGhie1972" class="citation journal cs1">Alexander K, Akhtar M, Boar RB, McGhie JF, Barton DH (1972). "The removal of the 32-carbon atom as formic acid in cholesterol biosynthesis". <i>Journal of the Chemical Society, Chemical Communications</i> (7): 383. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1039%2FC39720000383">10.1039/C39720000383</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+the+Chemical+Society%2C+Chemical+Communications&rft.atitle=The+removal+of+the+32-carbon+atom+as+formic+acid+in+cholesterol+biosynthesis&rft.issue=7&rft.pages=383&rft.date=1972&rft_id=info%3Adoi%2F10.1039%2FC39720000383&rft.aulast=Alexander&rft.aufirst=K&rft.au=Akhtar%2C+M&rft.au=Boar%2C+RB&rft.au=McGhie%2C+JF&rft.au=Barton%2C+DH&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALanosterol+14+alpha-demethylase" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lanosterol_14_alpha-demethylase&action=edit&section=7" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=cytochrome+P-450+CYP51">cytochrome+P-450+CYP51</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Cytochromes,_oxygenases:_cytochrome_P450_(Most_belong_to_EC_1.14)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytochrome_P450" title="Template:Cytochrome P450"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytochrome_P450" title="Template talk:Cytochrome P450"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytochrome_P450" title="Special:EditPage/Template:Cytochrome P450"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytochromes,_oxygenases:_cytochrome_P450_(Most_belong_to_EC_1.14)" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytochrome" title="Cytochrome">Cytochromes</a>, <a href="/wiki/Oxygenase" title="Oxygenase">oxygenases</a>: <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> (Most belong to <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.14)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP1</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP1A1" title="CYP1A1">A1</a></li> <li><a href="/wiki/CYP1A2" title="CYP1A2">A2</a></li> <li><a href="/w/index.php?title=CYP1A5&action=edit&redlink=1" class="new" title="CYP1A5 (page does not exist)">A5</a></li> <li><a href="/wiki/CYP1B1" title="CYP1B1">B1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP2</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP2A6" title="CYP2A6">A6</a></li> <li><a href="/wiki/CYP2A7" title="CYP2A7">A7</a></li> <li><a href="/wiki/CYP2A13" title="CYP2A13">A13</a></li> <li><a href="/wiki/CYP2B6" title="CYP2B6">B6</a></li> <li><a href="/wiki/CYP2C8" title="CYP2C8">C8</a></li> <li><a href="/wiki/CYP2C9" title="CYP2C9">C9</a></li> <li><a href="/wiki/CYP2C18" title="CYP2C18">C18</a></li> <li><a href="/wiki/CYP2C19" title="CYP2C19">C19</a></li> <li><a href="/wiki/CYP2D6" title="CYP2D6">D6</a></li> <li><a href="/wiki/CYP2E1" title="CYP2E1">E1</a></li> <li><a href="/wiki/CYP2F1" title="CYP2F1">F1</a></li> <li><a href="/wiki/CYP2J2" title="CYP2J2">J2</a></li> <li><a href="/wiki/CYP2R1" title="CYP2R1">R1</a></li> <li><a href="/wiki/CYP2S1" title="CYP2S1">S1</a></li> <li><a href="/wiki/CYP2U1" title="CYP2U1">U1</a></li> <li><a href="/wiki/CYP2W1" title="CYP2W1">W1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP3 (<a href="/wiki/CYP3A" title="CYP3A">CYP3A</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP3A4" title="CYP3A4">A4</a></li> <li><a href="/wiki/CYP3A5" title="CYP3A5">A5</a></li> <li><a href="/wiki/CYP3A7" title="CYP3A7">A7</a></li> <li><a href="/w/index.php?title=CYP3A37&action=edit&redlink=1" class="new" title="CYP3A37 (page does not exist)">A37</a></li> <li><a href="/wiki/CYP3A43" title="CYP3A43">A43</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP4</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP4A11" title="CYP4A11">A11</a></li> <li><a href="/wiki/CYP4A22" title="CYP4A22">A22</a></li> <li><a href="/wiki/CYP4B1" title="CYP4B1">B1</a></li> <li><a href="/wiki/CYP4F2" title="CYP4F2">F2</a></li> <li><a href="/wiki/CYP4F3" title="CYP4F3">F3</a></li> <li><a href="/wiki/CYP4F8" title="CYP4F8">F8</a></li> <li><a href="/wiki/CYP4F11" title="CYP4F11">F11</a></li> <li><a href="/wiki/CYP4F12" title="CYP4F12">F12</a></li> <li><a href="/wiki/CYP4F22" title="CYP4F22">F22</a></li> <li><a href="/wiki/CYP4V2" title="CYP4V2">V2</a></li> <li><a href="/wiki/CYP4X1" title="CYP4X1">X1</a></li> <li><a href="/wiki/CYP4Z1" title="CYP4Z1">Z1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP5-20</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP5</i> (<a href="/wiki/Thromboxane-A_synthase" title="Thromboxane-A synthase">A1</a>)</li> <li><i><a href="/wiki/CYP6_family" title="CYP6 family">CYP6</a></i> (<a href="/wiki/CYP6G1" title="CYP6G1">G1</a>, <a href="/wiki/CYP6M2" title="CYP6M2">M2</a>)</li> <li><i>CYP7</i> (<a href="/wiki/Cholesterol_7_alpha-hydroxylase" title="Cholesterol 7 alpha-hydroxylase">A1</a>, <a href="/wiki/CYP7B1" title="CYP7B1">B1</a>)</li> <li><i>CYP8</i> (<a href="/wiki/CYP8A1" class="mw-redirect" title="CYP8A1">A1</a>, <a href="/wiki/CYP8B1" title="CYP8B1">B1</a>)</li> <li><i><a href="/wiki/CYP9_family" title="CYP9 family">CYP9</a></i></li> <li><i><a href="/wiki/CYP10_family" title="CYP10 family">CYP10</a></i></li> <li><i><a href="/wiki/CYP11_family" title="CYP11 family">CYP11</a></i> (<a href="/wiki/Cholesterol_side-chain_cleavage_enzyme" title="Cholesterol side-chain cleavage enzyme">A1</a>, <a href="/wiki/CYP11A2" title="CYP11A2">A2</a>, <a href="/wiki/Steroid_11-beta-hydroxylase" class="mw-redirect" title="Steroid 11-beta-hydroxylase">B1</a>, <a href="/wiki/Aldosterone_synthase" title="Aldosterone synthase">B2</a>, <a href="/wiki/CYP11B3" title="CYP11B3">B3</a>, <a href="/wiki/CYP11C1" title="CYP11C1">C1</a>)</li> <li><i><a href="/wiki/CYP12_family" title="CYP12 family">CYP12</a></i></li> <li><i><a href="/wiki/CYP13_family" title="CYP13 family">CYP13</a></i></li> <li><i><a href="/wiki/CYP14_family" title="CYP14 family">CYP14</a></i></li> <li><i><a href="/wiki/CYP15_family" title="CYP15 family">CYP15</a></i></li> <li><i><a href="/wiki/CYP16_family" title="CYP16 family">CYP16</a></i></li> <li><i>CYP17</i> (<a href="/wiki/CYP17A1" title="CYP17A1">A1</a>)</li> <li><i><a href="/wiki/CYP18_family" title="CYP18 family">CYP18</a></i></li> <li><i>CYP19</i> (<a href="/wiki/Aromatase" title="Aromatase">A1</a>)</li> <li><i>CYP20</i> (<a href="/wiki/CYP20A1" title="CYP20A1">A1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP21-49</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP21</i> (<a href="/wiki/21-Hydroxylase" title="21-Hydroxylase">A2</a>)</li> <li><i>CYP22</i> (<a href="/wiki/Daf-9" title="Daf-9">A1</a>)</li> <li><i><a href="/wiki/CYP23_family" title="CYP23 family">CYP23</a></i></li> <li><i>CYP24</i> (<a href="/wiki/CYP24A1" title="CYP24A1">A1</a>)</li> <li><i><a href="/wiki/CYP25_family" title="CYP25 family">CYP25</a></i></li> <li><i><a href="/wiki/CYP26_family" title="CYP26 family">CYP26</a></i> (<a href="/wiki/CYP26A1" title="CYP26A1">A1</a>, <a href="/wiki/CYP26B1" title="CYP26B1">B1</a>, <a href="/wiki/CYP26C1" title="CYP26C1">C1</a>)</li> <li><i><a href="/wiki/CYP27_family" title="CYP27 family">CYP27</a></i> (<a href="/wiki/CYP27A1" title="CYP27A1">A1</a>, <a href="/wiki/25-Hydroxyvitamin_D3_1-alpha-hydroxylase" class="mw-redirect" title="25-Hydroxyvitamin D3 1-alpha-hydroxylase">B1</a>, <a href="/wiki/CYP27C1" title="CYP27C1">C1</a>)</li> <li><i>CYP28</i> (<a href="/wiki/CYP28A1" title="CYP28A1">A1</a>)</li> <li><i><a href="/w/index.php?title=CYP29_family&action=edit&redlink=1" class="new" title="CYP29 family (page does not exist)">CYP29</a></i></li> <li><i>CYP35</i> (<a href="/wiki/CYP35B1" title="CYP35B1">B1</a>)</li> <li><i>CYP39</i> (<a href="/wiki/CYP39A1" title="CYP39A1">A1</a>)</li> <li><i>CYP46</i> (<a href="/wiki/CYP46A1" class="mw-redirect" title="CYP46A1">A1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP51-69</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Sterol_14-demethylase" title="Sterol 14-demethylase">CYP51</a></i> (<a class="mw-selflink selflink">A1</a>, <a href="/wiki/ERG11" title="ERG11">F1</a>)</li> <li><i><a href="/wiki/CYP52_family" title="CYP52 family">CYP52</a></i></li> <li><i><a href="/wiki/CYP53_family" title="CYP53 family">CYP53</a></i> <ul><li><a href="/wiki/Benzoate_4-monooxygenase" title="Benzoate 4-monooxygenase">A1</a></li></ul></li> <li><i><a href="/wiki/CYP55_family" title="CYP55 family">CYP55</a></i> <ul><li><a href="/wiki/Nitric_oxide_reductase_(NAD(P),_nitrous_oxide-forming)" title="Nitric oxide reductase (NAD(P), nitrous oxide-forming)">A1</a></li></ul></li> <li><i>CYP56</i> <ul><li><a href="/wiki/CYP56A1" title="CYP56A1">A1</a></li></ul></li> <li><i><a href="/wiki/ERG5" title="ERG5">CYP61</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP71-99</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP71</i> (<a href="/wiki/3-hydroxyindolin-2-one_monooxygenase" title="3-hydroxyindolin-2-one monooxygenase">C1</a>, <a href="/wiki/Indolin-2-one_monooxygenase" title="Indolin-2-one monooxygenase">C2</a>, <a href="/wiki/2-Hydroxy-1,4-benzoxazin-3-one_monooxygenase" title="2-Hydroxy-1,4-benzoxazin-3-one monooxygenase">C3</a>, <a href="/wiki/Indole-2-monooxygenase" title="Indole-2-monooxygenase">C4</a>, <a href="/wiki/Ent-isokaurene_C2-hydroxylase" title="Ent-isokaurene C2-hydroxylase">Z6</a>, <a href="/wiki/Angelicin_synthase" title="Angelicin synthase">AJ4</a>, <a href="/wiki/Amorpha-4,11-diene_12-monooxygenase" title="Amorpha-4,11-diene 12-monooxygenase">AV1</a>, <a href="/wiki/Alpha-humulene_10-hydroxylase" title="Alpha-humulene 10-hydroxylase">BA1</a>)</li> <li><i><a href="/wiki/Secologanin_synthase" title="Secologanin synthase">CYP72A1</a></i></li> <li><i><a href="/wiki/Trans-cinnamate_4-monooxygenase" title="Trans-cinnamate 4-monooxygenase">CYP73A1</a></i></li> <li><i><a href="/wiki/CYP74_family" title="CYP74 family">CYP74</a></i> (<a href="/wiki/Colneleate_synthase" title="Colneleate synthase">D1</a>)</li> <li><i>CYP75</i> (<a href="/wiki/Flavonoid_3%27,5%27-hydroxylase" title="Flavonoid 3',5'-hydroxylase">A1</a>, <a href="/wiki/Flavonoid_3%27-monooxygenase" title="Flavonoid 3'-monooxygenase">B1</a>)</li> <li><i><a href="/wiki/CYP76_family" title="CYP76 family">CYP76</a></i> (<a href="/wiki/Geraniol_8-hydroxylase" title="Geraniol 8-hydroxylase">B6</a>, <a href="/wiki/Ent-cassa-12,15-diene_11-hydroxylase" title="Ent-cassa-12,15-diene 11-hydroxylase">M7</a>)</li> <li><i>CYP79</i> (<a href="/wiki/Tyrosine_N-monooxygenase" title="Tyrosine N-monooxygenase">A1</a>, <a href="/wiki/Phenylalanine_N-monooxygenase" title="Phenylalanine N-monooxygenase">A2</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B1</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B2</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B3</a>, <a href="/wiki/Valine_N-monooxygenase" title="Valine N-monooxygenase">D1</a>, <a href="/wiki/Valine_N-monooxygenase" title="Valine N-monooxygenase">D2</a>, <a href="/wiki/Isoleucine_N-monooxygenase" title="Isoleucine N-monooxygenase">D3</a>, <a href="/wiki/Isoleucine_N-monooxygenase" title="Isoleucine N-monooxygenase">D4</a>)</li> <li><i>CYP80</i> (<a href="/wiki/Berbamunine_synthase" title="Berbamunine synthase">A1</a>, <a href="/wiki/N-methylcoclaurine_3%27-monooxygenase" title="N-methylcoclaurine 3'-monooxygenase">B1</a>, <a href="/wiki/(S)-corytuberine_synthase" title="(S)-corytuberine synthase">G2</a>)</li> <li><i>CYP81</i> (<a href="/wiki/Isoflavone_2%27-hydroxylase" title="Isoflavone 2'-hydroxylase">E1</a>, <a href="/wiki/4%27-methoxyisoflavone_2%27-hydroxylase" title="4'-methoxyisoflavone 2'-hydroxylase">E3</a>, <a href="/wiki/4%27-methoxyisoflavone_2%27-hydroxylase" title="4'-methoxyisoflavone 2'-hydroxylase">E7</a>, <a href="/wiki/Isoflavone_3%27-hydroxylase" title="Isoflavone 3'-hydroxylase">E9</a>)</li> <li><i><a href="/wiki/Beta-amyrin_11-oxidase" title="Beta-amyrin 11-oxidase">CYP88D6</a></i></li> <li><i><a href="/wiki/3-Epi-6-deoxocathasterone_23-monooxygenase" title="3-Epi-6-deoxocathasterone 23-monooxygenase">CYP90C1</a></i></li> <li><i><a href="/wiki/Beta-amyrin_24-hydroxylase" title="Beta-amyrin 24-hydroxylase">CYP93E1</a></i></li> <li><i><a href="/wiki/Carotene_epsilon-monooxygenase" title="Carotene epsilon-monooxygenase">CYP97C1</a></i></li> <li><i><a href="/wiki/9beta-pimara-7,15-diene_oxidase" title="9beta-pimara-7,15-diene oxidase">CYP99A3</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP101-281</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Camphor_5-monooxygenase" title="Camphor 5-monooxygenase">CYP101A1</a></i></li> <li><i><a href="/wiki/Cytochrome_P450_BM3" title="Cytochrome P450 BM3">CYP102A1</a></i></li> <li><i><a href="/wiki/CYP105_family" title="CYP105 family">CYP105</a></i> <ul><li><a href="/wiki/Vitamin_D3_dihydroxylase" title="Vitamin D3 dihydroxylase">A1</a></li> <li><a href="/wiki/Pentalenic_acid_synthase" title="Pentalenic acid synthase">D7</a></li></ul></li> <li><i><a href="/wiki/Steroid_15beta-monooxygenase" title="Steroid 15beta-monooxygenase">CYP106A2</a></i></li> <li><i><a href="/wiki/CYP107_family" title="CYP107 family">CYP107</a></i> <ul><li><a href="/wiki/Cytochrome_P450_eryF" title="Cytochrome P450 eryF">A1</a></li> <li><a href="/wiki/CYP107G1" title="CYP107G1">G1</a></li></ul></li> <li><i><a href="/wiki/CYP109_family" title="CYP109 family">CYP109</a></i> <ul><li><a href="/wiki/CYP109B1" title="CYP109B1">B1</a></li> <li><a href="/wiki/CYP109E1" title="CYP109E1">E1</a></li></ul></li> <li><i><a href="/wiki/Linalool_8-monooxygenase" title="Linalool 8-monooxygenase">CYP111</a></i></li> <li><i><a href="/wiki/Erythromycin_12_hydroxylase" title="Erythromycin 12 hydroxylase">CYP113A1</a></i></li> <li><i><a href="/wiki/CYP119A1" title="CYP119A1">CYP119A1</a></i></li> <li><i><a href="/wiki/CYP123_family" title="CYP123 family">CYP123</a></i></li> <li><i><a href="/wiki/Cholest-4-en-3-one_26-monooxygenase" title="Cholest-4-en-3-one 26-monooxygenase">CYP125A1</a></i></li> <li><i><a href="/wiki/CYP139_family" title="CYP139 family">CYP139</a></i></li> <li><i><a href="/wiki/CYP147_family" title="CYP147 family">CYP147</a></i></li> <li><i><a href="/wiki/Fatty-acid_peroxygenase" title="Fatty-acid peroxygenase">CYP152</a></i> <ul><li>A1</li> <li>B1</li></ul></li> <li><i><a href="/wiki/CYP154C3" title="CYP154C3">CYP154C3</a></i></li> <li><i><a href="/wiki/Biflaviolin_synthase" title="Biflaviolin synthase">CYP158A</a></i></li> <li><i><a href="/wiki/Pentalenolactone_synthase" title="Pentalenolactone synthase">CYP161C</a></i></li> <li><i>CYP170</i> <ul><li><i><a href="/wiki/Epi-isozizaene_5-monooxygenase" title="Epi-isozizaene 5-monooxygenase">A1</a></i></li> <li><i><a href="/wiki/CYP170B1" title="CYP170B1">B1</a></i></li></ul></li> <li><i><a href="/wiki/1,8-Cineole_2-endo-monooxygenase" title="1,8-Cineole 2-endo-monooxygenase">CYP176A1</a></i></li> <li><i><a href="/wiki/Pentalenene_oxygenase" title="Pentalenene oxygenase">CYP183A</a></i></li> <li><i><a href="/wiki/CYP197_family" title="CYP197 family">CYP197</a></i></li> <li><i><a href="/wiki/4-methoxybenzoate_monooxygenase_(O-demethylating)" title="4-methoxybenzoate monooxygenase (O-demethylating)">CYP199A2</a></i></li> <li><i><a href="/wiki/Cytochrome_P450_aromatic_O-demethylase" title="Cytochrome P450 aromatic O-demethylase">CYP255A</a> </i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP301-499</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CYP303A1" title="CYP303A1">CYP303A1</a></i></li> <li><i><a href="/wiki/CYP305_family" title="CYP305 family">CYP305</a></i> <ul><li><a href="/wiki/CYP305M2" title="CYP305M2">M2</a></li></ul></li> <li><a href="/wiki/Halloween_genes" title="Halloween genes">Halloween genes</a> ( <i>CYP302A1</i>, <i>CYP306A1</i>, <i>CYP307A1</i>, <i>CYP307A2</i>, <i><a href="/wiki/Ecdysone_20-monooxygenase" title="Ecdysone 20-monooxygenase">CYP314A1</a></i>, <i>CYP315A1</i>)</li> <li><i><a href="/wiki/CYP318A1" title="CYP318A1">CYP318A1</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP501-699</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Ent-kaurene_oxidase" title="Ent-kaurene oxidase">CYP503</a></i></li> <li><i><a href="/wiki/3-hydroxyphenylacetate_6-hydroxylase" title="3-hydroxyphenylacetate 6-hydroxylase">CYP504B1</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP701-999</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CYP704B22" class="mw-redirect" title="CYP704B22">CYP704B22</a></i></li> <li><i><a href="/wiki/CYP710_family" title="CYP710 family">CYP710</a></i></li> <li><i><a href="/wiki/Abietadienol_hydroxylase" title="Abietadienol hydroxylase">CYP720A1</a></i></li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 0;column-gap:1em;align-items:baseline;margin:0;list-style:none}.mw-parser-output .portal-bar-content-related{margin:0;list-style:none}.mw-parser-output .portal-bar-item{display:inline-block;margin:0.15em 0.2em;min-height:24px;line-height:24px}@media screen and (max-width:768px){.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;flex-flow:column wrap;align-items:baseline}.mw-parser-output .portal-bar-header{text-align:center;flex:0;padding-left:0.5em;margin:0 auto}.mw-parser-output .portal-bar-related{font-size:100%;align-items:flex-start}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;align-items:center;flex:0;column-gap:1em;border-top:1px solid #a2a9b1;margin:0 auto;list-style:none}.mw-parser-output .portal-bar-content-related{border-top:none;margin:0;list-style:none}}.mw-parser-output .navbox+link+.portal-bar,.mw-parser-output .navbox+style+.portal-bar,.mw-parser-output .navbox+link+.portal-bar-bordered,.mw-parser-output .navbox+style+.portal-bar-bordered,.mw-parser-output .sister-bar+link+.portal-bar,.mw-parser-output .sister-bar+style+.portal-bar,.mw-parser-output .portal-bar+.navbox-styles+.navbox,.mw-parser-output .portal-bar+.navbox-styles+.sister-bar{margin-top:-1px}</style><div class="portal-bar noprint metadata noviewer portal-bar-unbordered" role="navigation" aria-label="Portals"><span class="portal-bar-header"><a href="/wiki/Wikipedia:Contents/Portals" title="Wikipedia:Contents/Portals">Portal</a>:</span><ul class="portal-bar-content"><li class="portal-bar-item"><span class="nowrap"><span typeof="mw:File"><a href="/wiki/File:Issoria_lathonia.jpg" class="mw-file-description"><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/21px-Issoria_lathonia.jpg" decoding="async" width="21" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/32px-Issoria_lathonia.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/42px-Issoria_lathonia.jpg 2x" data-file-width="629" data-file-height="445" /></a></span> </span><a href="/wiki/Portal:Biology" title="Portal:Biology">Biology</a></li></ul></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Lanosterol_14_alpha-demethylase&oldid=1189981848">https://en.wikipedia.org/w/index.php?title=Lanosterol_14_alpha-demethylase&oldid=1189981848</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_7" title="Category:Genes on human chromosome 7">Genes on human chromosome 7</a></li><li><a href="/wiki/Category:EC_1.14.14" title="Category:EC 1.14.14">EC 1.14.14</a></li><li><a href="/wiki/Category:Cytochrome_P450" title="Category:Cytochrome P450">Cytochrome P450</a></li><li><a href="/wiki/Category:NADPH-dependent_enzymes" title="Category:NADPH-dependent enzymes">NADPH-dependent enzymes</a></li><li><a href="/wiki/Category:Enzymes_of_known_structure" title="Category:Enzymes of known structure">Enzymes of known structure</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:Protein_pages_needing_a_picture" title="Category:Protein pages needing a picture">Protein pages needing a picture</a></li><li><a href="/wiki/Category:Human_gene_pages_with_Wikidata_item" title="Category:Human gene pages with Wikidata item">Human gene pages with Wikidata item</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 15 December 2023, at 05:53<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=Lanosterol_14_alpha-demethylase&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-f69cdc8f6-7pnpd","wgBackendResponseTime":182,"wgPageParseReport":{"limitreport":{"cputime":"0.640","walltime":"0.906","ppvisitednodes":{"value":1807,"limit":1000000},"postexpandincludesize":{"value":115478,"limit":2097152},"templateargumentsize":{"value":1164,"limit":2097152},"expansiondepth":{"value":11,"limit":100},"expensivefunctioncount":{"value":35,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":71221,"limit":5000000},"entityaccesscount":{"value":33,"limit":400},"timingprofile":["100.00% 790.765 1 -total"," 51.57% 407.774 1 Template:Infobox_gene"," 12.98% 102.602 1 Template:Short_description"," 10.45% 82.673 1 Template:Cytochrome_P450"," 10.21% 80.772 1 Template:Navbox"," 8.55% 67.605 2 Template:Infobox"," 7.50% 59.286 1 Template:Reflist"," 6.91% 54.652 2 Template:Pagetype"," 6.61% 52.245 12 Template:Cite_journal"," 6.53% 51.616 1 Template:Infobox_protein"]},"scribunto":{"limitreport-timeusage":{"value":"0.464","limit":"10.000"},"limitreport-memusage":{"value":8413420,"limit":52428800}},"cachereport":{"origin":"mw-web.codfw.main-f69cdc8f6-bndbt","timestamp":"20241122142343","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Lanosterol 14 alpha-demethylase","url":"https:\/\/en.wikipedia.org\/wiki\/Lanosterol_14_alpha-demethylase","sameAs":"http:\/\/www.wikidata.org\/entity\/Q17912234","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q17912234","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2007-04-26T07:00:17Z","dateModified":"2023-12-15T05:53:46Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/9\/99\/Ideogram_human_chromosome_7.svg","headline":"protein-coding gene in the species Homo sapiens"}</script> </body> </html>