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16px;font-size:14px;font-family:Roboto,Arial,Helvetica,sans-serif;line-height:36px;letter-spacing:.5px;text-transform:uppercase;-webkit-box-shadow:none;box-shadow:none;text-decoration:none;color:#fff;background-color:#00bcd4}.webmd-input__inner,.webmd-label,.webmd-label.labelup{font-weight:400;letter-spacing:normal}.webmd-button.material:active,.webmd-button.material:focus,.webmd-button.material:hover{color:#fff;background-color:#0097a7}.webmd-button.material.is-shadow{-webkit-box-shadow:0 2px 4px 0 rgba(0,0,0,.3);box-shadow:0 2px 4px 0 rgba(0,0,0,.3)}.webmd-button.material.is-capitalized{text-transform:capitalize}.webmd-button:hover{background-color:#00588c;color:#fff}.webmd-button+.webmd-button{margin-left:.625rem}.webmd-button::-moz-focus-inner{border-style:none}.webmd-button.is-icon{padding-left:1rem;padding-right:1rem}.webmd-button [class*=webmd-icon-]+span{margin-left:.3125rem}.webmd-button.is-disabled:hover{color:#767674;cursor:not-allowed;background-image:none;background-color:#e8e6e6;border:.0625rem;-webkit-box-shadow:none;box-shadow:none}.webmd-button.is-disabled.webmd-button--text{background-color:transparent}.webmd-button.is-disabled.material,.webmd-button.is-disabled.material:active,.webmd-button.is-disabled.material:focus,.webmd-button.is-disabled.material:hover{color:#767674;background-color:#e8e6e6}.webmd-button.is-disabled.material{cursor:not-allowed}.webmd-button.is-disabled.material.is-shadow:hover{-webkit-box-shadow:0 2px 4px 0 rgba(0,0,0,.3);box-shadow:0 2px 4px 0 rgba(0,0,0,.3)}.webmd-button.is-loading{position:relative;pointer-events:none}.webmd-button.is-loading:before{pointer-events:none;content:"";position:absolute;left:-.0625rem;top:-.0625rem;right:-.0625rem;bottom:-.0625rem;border-radius:inherit;background-color:hsla(0,0%,100%,.35)}.webmd-button.is-round{border-radius:1.25rem;padding:.75rem 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.webmd-checkbox__inner{background:url("data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iOSIgaGVpZ2h0PSI3IiBmaWxsPSJub25lIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0xLjM4NCAzLjExNWwyLjI1IDIuMDE5IDMuNzUtNC4wMzgiIHN0cm9rZT0iIzM1NTdGRiIgc3Ryb2tlLXdpZHRoPSIyIiBzdHJva2UtbGluZWNhcD0icm91bmQiIHN0cm9rZS1saW5lam9pbj0icm91bmQiLz48L3N2Zz4=") no-repeat;background-position:50%;background-size:.5625rem}@media only screen and (max-width:47.938em){.nlhov-content-container .series-select{display:block;margin-bottom:0}.nlhov-content-container .series-select .webmd-checkbox{padding-bottom:10px!important}}.footer-nl-social .success-reg h2{font-weight:600;line-height:50px;text-align:left}@media(max-width:47.938rem){.footer-nl-social .success-reg h2{text-align:center}}.footer-nl-social .success-reg .see-more-container{-webkit-box-align:self-start;-ms-flex-align:self-start;align-items:self-start;-webkit-box-pack:left;-ms-flex-pack:left;justify-content:left}@media(max-width:47.938rem){.footer-nl-social .success-reg .see-more-container{-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center}}.footer-nl-social .success-reg .sub-title-text{color:#fff;line-height:20px}@media(max-width:47.938rem){.footer-nl-social .success-reg .sub-title-text{-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center}}.in-art-ty h2,.right-cont h2{color:#1b1b1b;font-size:1.375rem;font-weight:700;line-height:30.8px;margin-bottom:.75rem}@media(max-width:64rem){.in-art-ty h2,.right-cont h2{font-size:2rem;line-height:42px;margin-bottom:1rem}}@media(max-width:47.938rem){.in-art-ty h2,.right-cont h2{font-size:1.5rem;line-height:33.6px;margin-bottom:.25rem}}.in-art-ty .see-more-container,.right-cont .see-more-container{-webkit-box-align:left;-ms-flex-align:left;align-items:left;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:left;-ms-flex-pack:left;justify-content:left;margin-top:1rem}@media(max-width:64rem){.in-art-ty .see-more-container,.right-cont .see-more-container{margin-bottom:.75rem}}@media(max-width:47.938rem){.in-art-ty .see-more-container,.right-cont .see-more-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center}}.in-art-ty .see-more-container .see-more-btn,.right-cont .see-more-container .see-more-btn{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:#3557ff;border-radius:4px;color:#fff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;font-size:1.125rem;font-weight:600;-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center;line-height:28.8px;min-width:150px;padding:8px 16px;text-decoration:none}.in-art-ty .sub-title-text,.right-cont .sub-title-text{font-size:1.125rem;line-height:28.8px}.vn-scrim:before{background:hsla(0,0%,100%,.8);content:"";height:100%;left:0;opacity:0;position:fixed;top:0;width:100%;visibility:hidden;z-index:100000;-webkit-transition:all .4s ease;transition:all .4s ease}@media(min-width:64.0625rem){.vn-scrim:before{-webkit-transition-delay:.2s;transition-delay:.2s}}.vn-scrim.vn-open:before{opacity:1;visibility:visible;-webkit-transition-delay:0s;transition-delay:0s}@media(min-width:64.0625rem){.vn-scrim.vn-open:before :not(.lite){visibility:hidden}}html body{margin-top:3rem;padding-top:0;-webkit-font-smoothing:antialiased}@media(max-width:37.5rem){html body main{margin-top:1rem}}@media(min-width:64.0625rem){html body{margin-top:0}}html.class-bg-ghost{background:#f8f8f8}.vn-typeahead-suggestions{background:#fff;border-radius:5px;-webkit-box-shadow:none;box-shadow:none;left:0!important;margin:0 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1.5rem}}.vn-wrapper.no-stick{position:relative}.vn-wrapper *{-webkit-box-sizing:border-box;box-sizing:border-box;font-family:Source Sans Pro,Arial,sans-serif;letter-spacing:normal}.vn-wrapper.vn-slide-up{-webkit-transform:translateY(-100%);transform:translateY(-100%)}@media(min-width:64.0625rem){.vn-wrapper{position:relative}}@media(max-width:81.25rem){.vn-wrapper{padding:0 1rem}}.vn-wrapper .vn-dt{display:none!important}@media(min-width:64.0625rem){.vn-wrapper .vn-dt{display:block!important}}.vn-wrapper .vn-mb{display:block}@media(min-width:48rem){.vn-wrapper .vn-mb{display:none!important}}.vn-wrapper .vn-tb{display:none}@media(min-width:48rem){.vn-wrapper .vn-tb{display:block}}.vn-wrapper .vn-mt{display:block}@media(min-width:64.0625rem){.vn-wrapper .vn-mt{display:none!important}}.vn-wrapper .vn-hidden{visibility:hidden!important}.vn-wrapper .vn-trans{opacity:0}.vn-wrapper .vn-none{display:none!important}@media(min-width:64.0625rem){.vn-wrapper .vn-none{display:none!important}}.vn-wrapper .vn-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;height:3rem;margin:0 auto;max-width:77.5rem;z-index:1}@media(min-width:64.0625rem){.vn-wrapper .vn-container{height:4.6875rem}}.vn-wrapper .vn-container.lite{max-width:100%}@media(min-width:64.0625rem){.vn-wrapper .vn-container.lite{height:3.5rem}}.vn-wrapper .vn-menu-btn{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#fff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;height:100%;line-height:1;padding:0}.vn-wrapper .vn-menu-btn:not(.lite){margin-right:1.166875rem}@media(min-width:64.0625rem){.vn-wrapper .vn-menu-btn:not(.lite){margin-right:0}}.vn-wrapper .vn-menu-btn i{font-size:2.25rem;width:2.25rem;overflow:hidden}.vn-wrapper .vn-menu-btn svg{fill:currentColor;pointer-events:none}.vn-wrapper .vn-menu-btn.vn-search i{font-size:1.875rem;width:1.875rem}.vn-wrapper .vn-menu-btn.vn-search:not(.lite){margin-right:0}@media(min-width:64.0625rem){.vn-wrapper .vn-menu-btn.vn-search:not(.lite) i{font-size:1.625rem;width:1.625rem}}.vn-wrapper .vn-menu-btn.vn-search.lite i{font-size:2rem;width:2rem}.vn-wrapper .vn-logo-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex}.vn-wrapper .vn-logo-container .vn-logo-div{height:.9375rem;margin:0 .625rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo-div{height:1.5625rem;margin:0 1.25rem}}.vn-wrapper .vn-logo-container .vn-logo,.vn-wrapper .vn-logo-container .vn-prog-logo{line-height:1}.vn-wrapper .vn-logo-container .vn-logo img,.vn-wrapper .vn-logo-container .vn-prog-logo img{display:block;height:1.3125rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo img,.vn-wrapper .vn-logo-container .vn-prog-logo img{height:1.625rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo img:not(.lite){width:7.25rem}}.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:.875rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:1.4375rem}}.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:.9375rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:1.5625rem}}.vn-wrapper .vn-links{background:#f9f9fc;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;height:calc(100vh - 3rem);left:-140vw;overflow:auto;padding:.5rem;position:fixed;top:3rem;-webkit-transition:left .5s ease;transition:left .5s ease;width:100%;z-index:100}@media(min-width:37.5rem){.vn-wrapper .vn-links{max-width:25rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links.lite{height:calc(100vh - 3.5rem);top:3.5rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links:not(.lite){background:none;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row;height:100%;left:0;max-width:100%;overflow:visible;padding:0;position:relative;top:0}}.vn-wrapper .vn-links.open{left:0}.vn-wrapper .vn-links.open.vn-slide-out{left:-100vw}@media(min-width:37.5rem){.vn-wrapper .vn-links.open.vn-slide-out{left:0}}.vn-wrapper .vn-links .vn-search-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex;height:3rem;margin-bottom:.25rem;-webkit-box-ordinal-group:0;-ms-flex-order:-1;order:-1}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-search-wrapper:not(.lite){background:#fff;border:1px solid #c6cedb;border-radius:5px;opacity:0;-webkit-box-ordinal-group:2;-ms-flex-order:1;order:1;position:absolute;right:2.8125rem;top:.8125rem;width:38%;-webkit-transition:all .3s ease;transition:all .3s ease;visibility:hidden}.vn-wrapper .vn-links .vn-search-wrapper:not(.lite).vn-open{visibility:visible;opacity:1}.vn-wrapper .vn-links .vn-search-wrapper:not(.lite) input{border:0;height:2.8125rem}}.vn-wrapper .vn-links .vn-search-wrapper>div{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1}.vn-wrapper .vn-links .vn-search-wrapper>div>div{width:100%}.vn-wrapper .vn-links .vn-search-wrapper input{border:1px solid #cccce7;border-right:0;border-radius:5px 0 0 5px;-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1;font-size:1.125rem;height:3rem;padding:0 1.375rem}.vn-wrapper .vn-links .vn-search-wrapper input::-webkit-input-placeholder{color:#7f888f}.vn-wrapper .vn-links .vn-search-wrapper input::-moz-placeholder{color:#7f888f}.vn-wrapper .vn-links .vn-search-wrapper input:-ms-input-placeholder{color:#7f888f}.vn-wrapper .vn-links .vn-search-wrapper input::-ms-input-placeholder{color:#7f888f}.vn-wrapper .vn-links .vn-search-wrapper input::placeholder{color:#7f888f}.vn-wrapper .vn-links .vn-search-wrapper button{background:#3557ff;border:0;border-radius:0 5px 5px 0;color:#fff;cursor:pointer;font-size:1rem;font-weight:600;height:3rem;padding:0 .75rem}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-search-wrapper button:not(.lite){border-radius:5px;font-weight:400;height:2.375rem;margin:.25rem}}.vn-wrapper .vn-links .vn-links-list{list-style:none;margin:0;padding:0}.vn-wrapper .vn-links .vn-links-list>li{background:#fff;border-radius:.3125rem;font-weight:700;height:3rem;margin-top:.125rem}.vn-wrapper .vn-links .vn-links-list>li a{-webkit-box-align:center;-ms-flex-align:center;align-items:center;color:#1b1b1b;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;height:100%;padding:0 1.125rem 0 .9375rem;text-decoration:none}.vn-wrapper .vn-links .vn-links-list>li a .webmd-icon-right-arrow{color:#3557ff}@media(min-width:64.0625rem){.vn-wrapper .vn-links 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class="webmd-breadcrumb__item"><span class="webmd-breadcrumb__inner" role><a>alpha-lipoic acid</a></span><i class="webmd-breadcrumb__separator"></i></li></ul><script type="application/ld+json">{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Vitamins & Supplements","item":"https://www.webmd.com/vitamins/index"},{"@type":"ListItem","position":2,"name":"alpha-lipoic acid"}]}</script></div></div></div></div><div class="webmd-row pane" style="" span="24" id="ContentPane15" tabindex="-1"><div class="header-section-template" chronic-id="091e9c5e81e2c5f5"><div class="header-section"><div class="vitamins-header"><h1 class="heading"><span class="Vitamin-title">ALPHA-LIPOIC ACID</span><span class="transformTextCap"> - Uses, Side Effects, <span class="combain-title"> and More </span></span></h1><div class="other-names"> OTHER NAME(S): A-Lipoic Acid, Acetate Replacing Factor, Acide Alp <span> ... </span><span class="data-toggle"><span> Show More <i class="webmd-icon-down-arrow common-drugs-btn-icon"></i></span></span></div><div class="other-names-nojs"> OTHER NAME(S): A-Lipoic Acid, Acetate Replacing Factor, Acide Alp <span> ... </span><span class="data-toggle"><span> Show More <i class="webmd-icon-down-arrow common-drugs-btn-icon"></i></span></span></div></div></div><div class="tabs-container-holder"><div class="tabs-container"><ul class="auto-tabs"><li class="tab-1 active-tab" data-target="overview-content" data-menu="tab-menu" data-clientheight="0"><a href="javascript:void()">Overview</a></li><li class="tab-2" data-target="uses-content" data-menu="tab-menu" data-clientheight="0"><a href="javascript:void()">Uses</a></li><li class="tab-3" data-target="sideeffects-content" data-menu="tab-menu" data-clientheight="0"><a href="javascript:void()">Side Effects</a></li><li class="tab-4" data-target="precautions-content" data-menu="tab-menu" data-clientheight="0"><a href="javascript:void()">Precautions</a></li><li class="tab-5" data-target="interactions-content" data-menu="tab-menu" data-clientheight="0"><a href="javascript:void()">Interactions</a></li><li class="tab-6" data-target="dosing-content" data-menu="tab-menu" data-clientheight="0"><a href="javascript:void()">Dosing</a></li><li><a href="https://reviews.webmd.com/vitamins-supplements/ingredientreview-767-ALPHA-LIPOIC-ACID"> Reviews (260) </a></li></ul><li class="fade"></li></div></div></div></div></div><main id="global-main" role="main" tabindex="-1" data-js="global-main" class="resp-3-col"><div class="webmd-row" style="" span="24"><div tabindex="-1" class="main-container main-container-1" data-js="main-container-1"></div><div class="webmd-col webmd-col-24 webmd-col-xs-24 webmd-col-sm-24 webmd-col-md-17 webmd-col-lg-13 webmd-col-xl-13 main-container main-container-2" style="" id="main-container" tabindex="-1" data-js="main-container-2"><div class="webmd-row pane" style="" id="ContentPane28" tabindex="-1"><div class="monograph-page" id="monograph-page" chronic-id="091e9c5e81e2787d"><div class="overview-page center-content tab-content active-tab" active-tab="true" id="overview-container"><h2 class="vitamins-monograph-content-headline"><span><svg width="24" height="26" viewbox="0 0 24 26" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M2.83331 25.25C2.2604 25.25 1.76995 25.046 1.36197 24.638C0.953989 24.2301 0.75 23.7396 0.75 23.1667V4.83331C0.75 4.2604 0.953989 3.76995 1.36197 3.36197C1.76995 2.95399 2.2604 2.75 2.83331 2.75H8.85419C9.0139 2.0139 9.38716 1.4132 9.97397 0.947906C10.5608 0.482635 11.2361 0.25 12 0.25C12.7639 0.25 13.4392 0.482635 14.026 0.947906C14.6128 1.4132 14.9861 2.0139 15.1458 2.75H21.1667C21.7396 2.75 22.2301 2.95399 22.638 3.36197C23.046 3.76995 23.25 4.2604 23.25 4.83331V23.1667C23.25 23.7396 23.046 24.2301 22.638 24.638C22.2301 25.046 21.7396 25.25 21.1667 25.25H2.83331ZM2.83331 23.1667H21.1667V4.83331H2.83331V23.1667ZM6.79166 20.25H13.3125C13.6076 20.25 13.855 20.1498 14.0547 19.9495C14.2543 19.7491 14.3542 19.5009 14.3542 19.2047C14.3542 18.9085 14.2543 18.6615 14.0547 18.4636C13.855 18.2656 13.6076 18.1667 13.3125 18.1667H6.79166C6.49653 18.1667 6.24914 18.2669 6.04947 18.4672C5.84982 18.6676 5.75 18.9158 5.75 19.212C5.75 19.5082 5.84982 19.7552 6.04947 19.9531C6.24914 20.151 6.49653 20.25 6.79166 20.25ZM6.79166 15.0417H17.2083C17.5035 15.0417 17.7509 14.9415 17.9505 14.7411C18.1502 14.5408 18.25 14.2925 18.25 13.9963C18.25 13.7002 18.1502 13.4531 17.9505 13.2552C17.7509 13.0573 17.5035 12.9583 17.2083 12.9583H6.79166C6.49653 12.9583 6.24914 13.0585 6.04947 13.2589C5.84982 13.4592 5.75 13.7075 5.75 14.0037C5.75 14.2998 5.84982 14.5469 6.04947 14.7448C6.24914 14.9427 6.49653 15.0417 6.79166 15.0417ZM6.79166 9.83331H17.2083C17.5035 9.83331 17.7509 9.73314 17.9505 9.53278C18.1502 9.33243 18.25 9.08417 18.25 8.788C18.25 8.49183 18.1502 8.24479 17.9505 8.04688C17.7509 7.84896 17.5035 7.75 17.2083 7.75H6.79166C6.49653 7.75 6.24914 7.85018 6.04947 8.05053C5.84982 8.25089 5.75 8.49915 5.75 8.79531C5.75 9.09148 5.84982 9.33852 6.04947 9.53644C6.24914 9.73435 6.49653 9.83331 6.79166 9.83331ZM12 4.16666C12.2847 4.16666 12.5295 4.06423 12.7344 3.85938C12.9392 3.6545 13.0417 3.40971 13.0417 3.125C13.0417 2.84027 12.9392 2.59548 12.7344 2.39063C12.5295 2.18575 12.2847 2.08331 12 2.08331C11.7153 2.08331 11.4705 2.18575 11.2656 2.39063C11.0608 2.59548 10.9583 2.84027 10.9583 3.125C10.9583 3.40971 11.0608 3.6545 11.2656 3.85938C11.4705 4.06423 11.7153 4.16666 12 4.16666Z" fill="#3557FF"></path></svg></span>Overview </h2><div><div class="vitamins-monograph-content overview-content">Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy.<br/><br/> Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in <a href="https://www.webmd.com/men/video/lamm-supplements-diet" crossLinkId="1600841" keywordSetId="9847" externalId="091e9c5e800ccbab" keywordId="40266" chronic_id="091e9c5e800ccbab" crossLinkType="Video" directive="friendlyurl" object_type="wbmd_pb_page">supplements</a>. Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain <a href="https://www.webmd.com/hepatitis/liver-and-hepatic-diseases" crossLinkId="1909768" keywordSetId="51561" externalId="091e9c5e81b881fe" keywordId="118047" chronic_id="091e9c5e81b881fe" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">liver diseases</a>.<br class='udpated-br' /><br/> People most commonly use alpha-lipoic acid for <a href="https://www.webmd.com/brain/nerve-pain-and-nerve-damage-symptoms-and-causes" crossLinkId="58569" keywordSetId="10418" externalId="091e9c5e8027ef13" keywordId="42698" chronic_id="091e9c5e8027ef13" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">nerve pain</a> in people with diabetes. It is also used for <a href="https://www.webmd.com/obesity/video/obesity-risks" crossLinkId="1542808" keywordSetId="1635" externalId="091e9c5e80047f6f" keywordId="7982" chronic_id="091e9c5e80047f6f" crossLinkType="Video" directive="friendlyurl" object_type="wbmd_pb_page">obesity</a>, altitude sickness, aging <a href="https://www.webmd.com/skin-problems-and-treatments/picture-of-the-skin" crossLinkId="70837" keywordSetId="26541" externalId="091e9c5e80396037" keywordId="60205" chronic_id="091e9c5e80396037" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">skin</a>, high levels of cholesterol or other fats in the <a href="https://www.webmd.com/heart/anatomy-picture-of-blood" crossLinkId="1506783" keywordSetId="28544" externalId="091e9c5e8056ea80" keywordId="62987" chronic_id="091e9c5e8056ea80" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">blood</a>, and many other purposes, but there is no good scientific evidence to support many of these other uses. <br/><br/> </div></div><div class="fifth-para-ad mobile-ads-holder ads-loaded"><span></span></div></div><div class="uses-container tab-content" id="uses-container"><h2 class="vitamins-monograph-content-headline"><span><svg width="18" height="24" viewbox="0 0 18 24" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M9.00881 18.6875C9.41527 18.6875 9.75564 18.5457 10.0299 18.2622C10.3042 17.9786 10.4414 17.6343 10.4414 17.2292V15.3333H12.3997C12.8048 15.3333 13.1492 15.1911 13.4327 14.9066C13.7163 14.622 13.8581 14.2766 13.8581 13.8701C13.8581 13.4636 13.7163 13.1198 13.4327 12.8386C13.1492 12.5573 12.8048 12.4167 12.3997 12.4167H10.4414V10.5C10.4414 10.0903 10.3042 9.74826 10.0299 9.47397C9.75564 9.19966 9.41527 9.0625 9.00881 9.0625C8.60235 9.0625 8.25686 9.19966 7.97234 9.47397C7.68784 9.74826 7.54559 10.0903 7.54559 10.5V12.4167H5.60806C5.20298 12.4167 4.85866 12.5589 4.57509 12.8434C4.29153 13.128 4.14975 13.4734 4.14975 13.8799C4.14975 14.2864 4.29153 14.6302 4.57509 14.9114C4.85866 15.1927 5.20298 15.3333 5.60806 15.3333H7.54559V17.25C7.54559 17.6597 7.68784 18.0017 7.97234 18.276C8.25686 18.5503 8.60235 18.6875 9.00881 18.6875ZM2.33722 23.25C1.7643 23.25 1.27385 23.046 0.865875 22.638C0.457896 22.2301 0.253906 21.7396 0.253906 21.1667V6.60416C0.253906 6.03124 0.457896 5.54079 0.865875 5.13281C1.27385 4.72483 1.7643 4.52084 2.33722 4.52084H15.6706C16.2435 4.52084 16.734 4.72483 17.1419 5.13281C17.5499 5.54079 17.7539 6.03124 17.7539 6.60416V21.2708C17.7539 21.8472 17.5499 22.3212 17.1419 22.6927C16.734 23.0642 16.2435 23.25 15.6706 23.25H2.33722ZM2.33722 21.2708H15.6706V6.60416H2.33722V21.2708ZM2.54556 2.83331C2.25044 2.83331 2.00304 2.73314 1.80337 2.53278C1.60373 2.33243 1.50391 2.08417 1.50391 1.788C1.50391 1.49183 1.60373 1.24479 1.80337 1.04688C2.00304 0.848958 2.25044 0.75 2.54556 0.75H15.4831C15.7782 0.75 16.0256 0.850177 16.2252 1.05053C16.4249 1.25089 16.5247 1.49915 16.5247 1.79531C16.5247 2.09148 16.4249 2.33852 16.2252 2.53644C16.0256 2.73435 15.7782 2.83331 15.4831 2.83331H2.54556Z" fill="#3557FF"></path></svg></span>Uses & <span class="question-mark-cont"> Effectiveness <svg class="question-mark" width="14" height="14" viewbox="0 0 14 14" fill="currentColor" xmlns="https://www.w3.org/2000/svg"><path d="M5.99842 10C6.19393 10 6.35975 9.9325 6.49586 9.79746C6.63197 9.66252 6.70002 9.49724 6.70002 9.30163C6.70002 9.10611 6.6325 8.9403 6.49746 8.80419C6.36252 8.66808 6.19724 8.60002 6.00163 8.60002C5.80611 8.60002 5.6403 8.66754 5.50419 8.80259C5.36808 8.93753 5.30002 9.10281 5.30002 9.29842C5.30002 9.49393 5.36755 9.65975 5.50259 9.79586C5.63753 9.93197 5.80281 10 5.99842 10ZM6.00411 12.1C5.23333 12.1 4.50766 11.9542 3.82711 11.6625C3.14655 11.3709 2.55107 10.9698 2.04065 10.4594C1.53023 9.94898 1.12919 9.35369 0.837524 8.67352C0.545858 7.99336 0.400024 7.26662 0.400024 6.49332C0.400024 5.72001 0.545858 4.99551 0.837524 4.31982C1.12919 3.64412 1.53023 3.05107 2.04065 2.54065C2.55107 2.03023 3.14636 1.62919 3.82652 1.33752C4.50669 1.04586 5.23343 0.900024 6.00673 0.900024C6.78004 0.900024 7.50454 1.04586 8.18023 1.33752C8.85593 1.62919 9.44898 2.03023 9.9594 2.54065C10.4698 3.05107 10.8709 3.64519 11.1625 4.32302C11.4542 5.00095 11.6 5.72526 11.6 6.49594C11.6 7.26672 11.4542 7.99238 11.1625 8.67294C10.8709 9.3535 10.4698 9.94898 9.9594 10.4594C9.44898 10.9698 8.85486 11.3709 8.17702 11.6625C7.49909 11.9542 6.77479 12.1 6.00411 12.1ZM6.00002 11.05C7.26391 11.05 8.33822 10.6077 9.22294 9.72294C10.1077 8.83822 10.55 7.76391 10.55 6.50002C10.55 5.23614 10.1077 4.16183 9.22294 3.27711C8.33822 2.39239 7.26391 1.95002 6.00002 1.95002C4.73614 1.95002 3.66183 2.39239 2.77711 3.27711C1.89239 4.16183 1.45002 5.23614 1.45002 6.50002C1.45002 7.76391 1.89239 8.83822 2.77711 9.72294C3.66183 10.6077 4.73614 11.05 6.00002 11.05ZM6.04713 3.99169C6.2932 3.99169 6.50728 4.07049 6.68938 4.22809C6.87148 4.38559 6.96252 4.58251 6.96252 4.81886C6.96252 5.03547 6.89933 5.22641 6.77294 5.39169C6.64655 5.55697 6.50072 5.70766 6.33544 5.84377C6.11183 6.03822 5.91252 6.25697 5.73752 6.50002C5.56252 6.74308 5.47989 7.0153 5.48961 7.31669C5.48961 7.4528 5.53861 7.56218 5.63661 7.64482C5.73461 7.72745 5.84894 7.76877 5.97961 7.76877C6.11961 7.76877 6.23822 7.72745 6.33544 7.64482C6.43266 7.56218 6.49586 7.4528 6.52502 7.31669C6.57364 7.1028 6.666 6.914 6.80211 6.75027C6.93822 6.58645 7.08405 6.43012 7.23961 6.28127C7.46322 6.06739 7.64551 5.82919 7.78648 5.56669C7.92745 5.30419 7.99794 5.02225 7.99794 4.72086C7.99794 4.22502 7.80593 3.81426 7.4219 3.48857C7.03787 3.16287 6.58136 3.00002 6.05238 3.00002C5.68692 3.00002 5.34134 3.08023 5.01565 3.24065C4.68995 3.40107 4.42911 3.63814 4.23311 3.95188C4.15689 4.06592 4.13579 4.191 4.16982 4.32711C4.20384 4.46322 4.28405 4.56044 4.41044 4.61877C4.54655 4.68683 4.68266 4.70141 4.81877 4.66252C4.95489 4.62364 5.06669 4.55072 5.15419 4.44377C5.26114 4.30766 5.39239 4.19829 5.54794 4.11565C5.7035 4.03301 5.86989 3.99169 6.04713 3.99169Z" fill="currentColor"></path></svg></span></h2><div><div class="vitamins-monograph-content uses-content"></div><div class="vitamins-monograph-content uses-content"></div><h3> Possibly Effective for </h3><div class="vitamins-monograph-content uses-content"><ul> <li><a href="https://www.webmd.com/pain-management/video/diagnosing-treating-nerve-pain" crossLinkId="1596825" keywordSetId="10418" externalId="091e9c5e804bb184" keywordId="42698" chronic_id="091e9c5e804bb184" crossLinkType="Video" directive="friendlyurl" object_type="wbmd_pb_page">Nerve pain</a> in people with diabetes (<a href="https://www.webmd.com/diabetes/diabetes-neuropathy" crossLinkId="1582687" keywordSetId="8581" externalId="091e9c5e80008426" keywordId="33971" chronic_id="091e9c5e80008426" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">diabetic neuropathy</a>). Taking 600-1800 mg of alpha-lipoic acid by <a href="https://www.webmd.com/oral-health/ss/slideshow-mouth-problems" crossLinkId="1624516" keywordSetId="40982" externalId="091e9c5e802bb621" keywordId="93494" chronic_id="091e9c5e802bb621" crossLinkType="Slideshows" directive="friendlyurl" object_type="wbmd_pb_page">mouth</a> or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. Lower doses of alpha-lipoic acid don't seem to work. IV products can only be given by a <a href="https://www.webmd.com/health-insurance/rm-quiz-insurance-basics" crossLinkId="1619843" keywordSetId="33248" externalId="091e9c5e80cee26e" keywordId="73362" chronic_id="091e9c5e80cee26e" crossLinkType="Tools" directive="friendlyurl" object_type="wbmd_pb_page">healthcare</a> provider.</li> <li class='udpated-li'>High levels of cholesterol or other fats (<a href="https://www.webmd.com/cholesterol-management/tests-for-high-cholesterol-lipid-panel" crossLinkId="59018" keywordSetId="49961" externalId="091e9c5e8028abb6" keywordId="114556" chronic_id="091e9c5e8028abb6" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">lipids</a>) in the blood (<a href="https://www.webmd.com/cholesterol-management/hyperlipidemia-overview" crossLinkId="1899328" keywordSetId="47197" externalId="091e9c5e813edc56" keywordId="108779" chronic_id="091e9c5e813edc56" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">hyperlipidemia</a>). Taking alpha-lipoic acid by <a href="https://www.webmd.com/oral-health/rm-quiz-mouth-myths" crossLinkId="1619208" keywordSetId="40982" externalId="091e9c5e80d71be5" keywordId="93494" chronic_id="091e9c5e80d71be5" crossLinkType="Tools" directive="friendlyurl" object_type="wbmd_pb_page">mouth</a> for up to 4 years seems to lower <a href="https://www.webmd.com/cholesterol-management/understanding-numbers" crossLinkId="8342" keywordSetId="8382" externalId="091e9c5e800081fd" keywordId="108937" chronic_id="091e9c5e800081fd" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">total cholesterol</a> and low-density lipoprotein (<a href="https://www.webmd.com/heart-disease/ldl-cholesterol-the-bad-cholesterol" crossLinkId="59022" keywordSetId="1461" externalId="091e9c5e8028aaf6" keywordId="42789" chronic_id="091e9c5e8028aaf6" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">LDL</a> or "bad") cholesterol in people with or without hyperlipidemia.</li> <li>Obesity. Taking alpha-lipoic acid by mouth can slightly reduce <a href="https://www.webmd.com/obesity/healthy-weight" crossLinkId="1903515" keywordSetId="8910" externalId="091e9c5e816856bb" keywordId="35915" chronic_id="091e9c5e816856bb" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">body weight</a> in adults who are overweight. </li></ul> </div><h3> Possibly Ineffective for </h3><div class="vitamins-monograph-content uses-content"><ul> <li>Liver disease in people who drink alcohol. Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve <a href="https://www.webmd.com/hepatitis/liver-function-test-lft" crossLinkId="1514148" keywordSetId="32870" externalId="091e9c5e8068dce6" keywordId="72818" chronic_id="091e9c5e8068dce6" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">liver function</a> or reduce <a href="https://www.webmd.com/digestive-disorders/picture-of-the-liver" crossLinkId="73851" keywordSetId="10464" externalId="091e9c5e80348a30" keywordId="42791" chronic_id="091e9c5e80348a30" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">liver</a> damage in people with alcohol-related liver disease.</li> <li>Altitude sickness. Taking alpha-lipoic acid by mouth along with <a href="https://www.webmd.com/vitamins-supplements/ingredientmono-1001-vitamin-c-ascorbic-acid.aspx?activeingredientid=1001&activeingredientname=vitamin-c-(ascorbic-acid)" crossLinkId="1884444" keywordSetId="31339" externalId="1001" keywordId="69419" chronic_id="" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">vitamin C</a> and <a href="https://www.webmd.com/vitamins-supplements/ingredientmono-954-vitamin-e.aspx?activeingredientid=954&activeingredientname=vitamin-e" crossLinkId="1884399" keywordSetId="41108" externalId="954" keywordId="93779" chronic_id="" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">vitamin E</a> does not seem to prevent altitude sickness.</li> <li><a href="https://www.webmd.com/kidney-stones/picture-of-the-kidneys" crossLinkId="72677" keywordSetId="26662" externalId="091e9c5e803f72c0" keywordId="60461" chronic_id="091e9c5e803f72c0" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">Kidney</a> damage caused by contrast dyes (contrast induced nephropathy). Taking alpha-lipoic acid by mouth with or without standard <a href="https://www.webmd.com/a-to-z-guides/dehydration-adults" crossLinkId="900" keywordSetId="1077" externalId="091e9c5e8000b073" keywordId="94660" chronic_id="091e9c5e8000b073" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">hydration</a> therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents.</li> <li>Diabetes. Taking alpha-lipoic acid by mouth or by IV does not improve blood sugar levels in people with <a href="https://www.webmd.com/diabetes/type-2-diabetes" crossLinkId="1582839" keywordSetId="2021" externalId="091e9c5e80010f55" keywordId="8505" chronic_id="091e9c5e80010f55" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">type 2 diabetes</a>. </li> <li><a href="https://www.webmd.com/eye-health/vision-basics" crossLinkId="3407" keywordSetId="1184" externalId="091e9c5e800076b7" keywordId="35136" chronic_id="091e9c5e800076b7" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">Vision</a> problems in people with diabetes (<a href="https://www.webmd.com/diabetes/diabetic-retinopathy" crossLinkId="1582790" keywordSetId="8582" externalId="091e9c5e80007e43" keywordId="33972" chronic_id="091e9c5e80007e43" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">diabetic retinopathy</a>). Taking alpha-lipoic acid by mouth daily for 24 months doesn't improve <a href="https://www.webmd.com/eye-health/picture-of-the-eyes" crossLinkId="72347" keywordSetId="26646" externalId="091e9c5e803ffc74" keywordId="60424" chronic_id="091e9c5e803ffc74" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">eye</a> damage from diabetes.</li> <li><a href="https://www.webmd.com/alzheimers/types-dementia" crossLinkId="1218" keywordSetId="47107" externalId="091e9c5e80008c55" keywordId="108635" chronic_id="091e9c5e80008c55" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">Dementia</a> in people with advanced <a href="https://www.webmd.com/hiv-aids/understanding-aids-hiv-basics" crossLinkId="1565792" keywordSetId="1340" externalId="091e9c5e80008960" keywordId="7583" chronic_id="091e9c5e80008960" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">HIV</a>/AIDS. Taking alpha-lipoic acid by mouth has no effect on thinking problems in people with HIV.</li> <li class='udpated-li-lazy'>High levels of fats called triglycerides in the blood (hypertriglyceridemia). Taking alpha-lipoic acid by mouth doesn't seem to reduce <a href="https://www.webmd.com/cholesterol-management/lowering-triglyceride-levels" crossLinkId="1560504" keywordSetId="2010" externalId="091e9c5e8028e149" keywordId="71913" chronic_id="091e9c5e8028e149" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">triglyceride levels</a> in most people.</li> </ul> There is interest in using alpha-lipoic acid for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful. </div><div class="vitamins-monograph-content uses-content"></div><div class="vitamins-monograph-content uses-content"></div></div><div class="uses-ad mobile-ad mobile-ads-holder"><span></span></div><div class="fifth-para-ad ads-loaded mobile-ads-holder"><span></span></div><div class="webmd-dialog__wrapper" style="display:none;"><div class="webmd-dialog webmd-dialog--center pop-over-dialog" style="margin-top:15vh;"><div class="webmd-dialog__header"><span class="webmd-dialog__title"></span><button type="button" class="webmd-dialog__headerbtn" aria-label="Close"><i class="webmd-dialog__close webmd-icon webmd-icon-close"></i></button></div></div></div></div><div class="side-effects-page tab-content" id="sideeffects-container"><h2 class="vitamins-monograph-content-headline"><span><svg width="28" height="28" viewbox="0 0 28 28" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M13.0074 2.4997C13.8566 2.4997 14.6701 2.57782 15.4479 2.73407C16.2257 2.89032 17.0972 3.15941 18.0625 3.54135L15.2083 4.8226C14.8611 4.73927 14.526 4.67851 14.2031 4.64032C13.8802 4.60211 13.4792 4.58301 13 4.58301C12.625 4.58301 12.2153 4.60732 11.7708 4.65595C11.3264 4.70455 10.9097 4.78788 10.5208 4.90595C11.8542 6.57261 13.316 7.91463 14.9062 8.93201C16.4965 9.94936 18.5764 10.3747 21.1459 10.208H21.2917L22.1354 12.1976C19.6632 12.5101 17.4028 12.2636 15.3542 11.458C13.3056 10.6525 11.5347 9.3608 10.0417 7.58301C9.32639 9.2983 8.31771 10.767 7.01562 11.9893C5.71354 13.2115 4.2361 14.1455 2.58331 14.7914C2.58331 17.7705 3.59547 20.2862 5.61978 22.3383C7.64409 24.3903 10.1042 25.4164 13 25.4164C15.9306 25.4164 18.4028 24.3921 20.4167 22.3434C22.4306 20.2948 23.4306 17.8469 23.4167 14.9997C23.4167 14.5969 23.3959 14.2375 23.3542 13.9216C23.3125 13.6056 23.2709 13.2983 23.2292 12.9997L24.5 10.0726C24.8472 10.9615 25.1007 11.7775 25.2604 12.5205C25.4201 13.2636 25.5 14.09 25.5 14.9997C25.5 16.708 25.1788 18.3209 24.5365 19.8382C23.8941 21.3556 23.0121 22.6803 21.8906 23.8122C20.7691 24.9441 19.4479 25.8417 17.9271 26.5049C16.4063 27.1681 14.7639 27.4997 13 27.4997C11.2639 27.4997 9.63543 27.175 8.11459 26.5257C6.59376 25.8764 5.2691 24.9875 4.14063 23.8591C3.01215 22.7306 2.12326 21.4059 1.47397 19.8851C0.824656 18.3643 0.5 16.7358 0.5 14.9997C0.5 13.2358 0.829865 11.5917 1.48959 10.0674C2.1493 8.5431 3.04686 7.22018 4.18228 6.09866C5.3177 4.97712 6.64235 4.09691 8.15625 3.45804C9.67015 2.81914 11.2872 2.4997 13.0074 2.4997ZM9.12969 14.6664C9.59183 14.6664 9.9809 14.8259 10.2969 15.145C10.6129 15.4641 10.7708 15.8547 10.7708 16.3169C10.7708 16.779 10.6113 17.1681 10.2922 17.4841C9.97308 17.8 9.58246 17.958 9.12031 17.958C8.65817 17.958 8.2691 17.7985 7.95312 17.4794C7.63715 17.1603 7.47916 16.7697 7.47916 16.3075C7.47916 15.8454 7.63871 15.4563 7.95781 15.1403C8.27692 14.8243 8.66754 14.6664 9.12969 14.6664ZM16.9005 14.6664C17.3627 14.6664 17.7517 14.8259 18.0677 15.145C18.3837 15.4641 18.5417 15.8547 18.5417 16.3169C18.5417 16.779 18.3821 17.1681 18.063 17.4841C17.7439 17.8 17.3533 17.958 16.8912 17.958C16.429 17.958 16.0399 17.7985 15.724 17.4794C15.408 17.1603 15.25 16.7697 15.25 16.3075C15.25 15.8454 15.4096 15.4563 15.7287 15.1403C16.0478 14.8243 16.4384 14.6664 16.9005 14.6664ZM22.875 0.770508L24.25 3.89551L27.3125 5.20801L24.25 6.54135L22.875 9.66635L21.4792 6.54135L18.4167 5.20801L21.4792 3.89551L22.875 0.770508ZM2.96872 12.2809C3.98955 11.8296 5.05901 11.0067 6.17709 9.81219C7.29516 8.61776 8.10071 7.19761 8.59375 5.55176C7.03125 6.29482 5.80902 7.24274 4.92706 8.39551C4.04513 9.5483 3.39234 10.8434 2.96872 12.2809Z" fill="#3557FF"></path></svg></span>Side Effects </h2><div><div class="vitamins-monograph-content side-effects-content"><b>When taken by mouth</b>: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting. <br/><br/> <b>When applied to the skin</b>: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people. </div></div><div class="sideeffects-ad mobile-ad mobile-ads-holder"><span></span></div><div class="fifth-para-ad ads-loaded mobile-ads-holder"><span></span></div></div><div class="precautions-page tab-content" id="precautions-container"><div class="vitamins-monograph-content-headline-holder"><h2 class="vitamins-monograph-content-headline"><span><svg width="26" height="24" viewbox="0 0 26 24" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M1.04969 23.2503C0.848316 23.2503 0.670181 23.2026 0.515285 23.1071C0.360389 23.0116 0.23992 22.8857 0.153879 22.7295C0.0612745 22.5753 0.010337 22.4083 0.0010662 22.2285C-0.0081838 22.0486 0.0427537 21.8684 0.153879 21.6878L12.0914 1.06284C12.2025 0.882274 12.3362 0.750326 12.4924 0.666992C12.6487 0.583659 12.8171 0.541992 12.9976 0.541992C13.1782 0.541992 13.3466 0.583659 13.5028 0.666992C13.6591 0.750326 13.7928 0.882274 13.9039 1.06284L25.8414 21.6878C25.9525 21.8684 26.0034 22.0486 25.9942 22.2285C25.9849 22.4083 25.934 22.5753 25.8414 22.7295C25.7553 22.8857 25.6349 23.0116 25.48 23.1071C25.3251 23.2026 25.1469 23.2503 24.9456 23.2503H1.04969ZM2.85178 21.167H23.1435L12.9976 3.66699L2.85178 21.167ZM13.0846 19.5628C13.3808 19.5628 13.6278 19.4627 13.8258 19.2623C14.0237 19.062 14.1226 18.8137 14.1226 18.5175C14.1226 18.2214 14.0225 17.9743 13.8221 17.7764C13.6217 17.5785 13.3735 17.4795 13.0773 17.4795C12.7811 17.4795 12.5341 17.5797 12.3362 17.7801C12.1383 17.9804 12.0393 18.2287 12.0393 18.5248C12.0393 18.821 12.1395 19.068 12.3398 19.266C12.5402 19.4639 12.7884 19.5628 13.0846 19.5628ZM13.0846 16.0003C13.3808 16.0003 13.6278 15.9005 13.8258 15.7009C14.0237 15.5012 14.1226 15.2538 14.1226 14.9587V10.292C14.1226 9.99685 14.0225 9.74945 13.8221 9.5498C13.6217 9.35016 13.3735 9.25034 13.0773 9.25034C12.7811 9.25034 12.5341 9.35016 12.3362 9.5498C12.1383 9.74945 12.0393 9.99685 12.0393 10.292V14.9587C12.0393 15.2538 12.1395 15.5012 12.3398 15.7009C12.5402 15.9005 12.7884 16.0003 13.0846 16.0003Z" fill="#3557FF"></path></svg></span>Special Precautions <span> and Warnings </span></h2></div><div><div class="vitamins-monograph-content precautions-content"><b>When taken by mouth</b>: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting. <br/><br/> <b>When applied to the skin</b>: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people. <hr style="clear:both;border: 1px solid transparent;"><b>Pregnancy</b>: When taken by mouth, alpha-lipoic acid is possibly safe. It's been used safely during pregnancy in doses of up to 600 mg daily for up to 4 weeks. <br class='udpated-br' /><br/> <b>Breast-feeding</b>: There isn't enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use.<br/><br/> <b>Children</b>: Alpha-lipoic acid is possibly safe in children aged 10-17 years when taken by mouth in doses up to 600 mg daily for 3 months. But it is possibly unsafe for children to take large amounts of alpha-lipoic acid by mouth. Seizures, vomiting, and unconsciousness have been reported for children aged 14 months to 16 years who took up to 2400 mg of alpha-lipoic acid as a single dose.<br/><br class='udpated-br-lazy' /> <b>Surgery</b>: Alpha-lipoic acid can decrease blood sugar levels. Alpha-lipoic acid might interfere with blood sugar control during and after surgery. Stop taking alpha-lipoic acid 2 weeks before elective surgical procedures.<br/><br/> <b>Excessive use of alcohol/<a href="https://www.webmd.com/brain/wernicke-korsakoff-syndrome-facts" crossLinkId="1907340" keywordSetId="10086" externalId="091e9c5e818dcd96" keywordId="41771" chronic_id="091e9c5e818dcd96" crossLinkType="Article" directive="friendlyurl" object_type="wbmd_pb_page">thiamine deficiency</a></b>: Alcohol can lower the amount of thiamine (vitamin B1) in the body. Taking alpha-lipoic acid when there is a shortage of thiamine might cause serious health problems. If you drink a lot of alcohol and take alpha-lipoic acid, you should take a thiamine supplement.<br/><br/> </div></div><div class="precautions-ad mobile-ad mobile-ads-holder"><span></span></div><div class="fifth-para-ad ads-loaded mobile-ads-holder"><span></span></div></div><div class="interactions-page center-content tab-content" id="interactions-container"><h2 class="vitamins-monograph-content-headline"><span><svg width="26" height="28" viewbox="0 0 26 28" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M18.5208 25.1042L20.1042 23.5L17.5 20.8958L15.8958 22.4792C15.5208 22.8542 15.3368 23.2917 15.3438 23.7917C15.3507 24.2917 15.5347 24.7292 15.8958 25.1042C16.2708 25.4653 16.7083 25.6493 17.2083 25.6562C17.7083 25.6632 18.1458 25.4792 18.5208 25.1042ZM21.5417 22.0625L23.1458 20.4792C23.5208 20.1042 23.7049 19.6667 23.6979 19.1667C23.691 18.6667 23.5 18.2292 23.125 17.8542C22.75 17.4792 22.3175 17.2917 21.8275 17.2917C21.3375 17.2917 20.9019 17.4792 20.5208 17.8542L18.9375 19.4583L21.5417 22.0625ZM19.9896 26.5729C19.2188 27.3437 18.2917 27.7291 17.2083 27.7291C16.125 27.7291 15.1979 27.3437 14.4271 26.5729C13.6563 25.8021 13.2708 24.875 13.2708 23.7917C13.2708 22.7083 13.6563 21.7812 14.4271 21.0104L19.0521 16.3854C19.8229 15.6146 20.75 15.2292 21.8333 15.2292C22.9167 15.2292 23.8438 15.6146 24.6146 16.3854C25.3854 17.1562 25.7708 18.0833 25.7708 19.1667C25.7708 20.25 25.3854 21.1771 24.6146 21.9479L19.9896 26.5729ZM2.83331 25.25C2.2604 25.25 1.76995 25.046 1.36197 24.638C0.953989 24.2301 0.75 23.7396 0.75 23.1667V4.83331C0.75 4.2604 0.953989 3.76995 1.36197 3.36197C1.76995 2.95399 2.2604 2.75 2.83331 2.75H8.85419C9.0139 2.0139 9.38716 1.4132 9.97397 0.947906C10.5608 0.482635 11.2361 0.25 12 0.25C12.7639 0.25 13.4392 0.482635 14.026 0.947906C14.6128 1.4132 14.9861 2.0139 15.1458 2.75H21.1667C21.7396 2.75 22.2301 2.95399 22.638 3.36197C23.046 3.76995 23.25 4.2604 23.25 4.83331V13.3021C22.9028 13.2118 22.5556 13.1597 22.2083 13.1458C21.8611 13.1319 21.5139 13.1493 21.1667 13.1979V4.83331H2.83331V23.1667H11.2188C11.184 23.5139 11.1771 23.8611 11.1979 24.2083C11.2188 24.5556 11.2743 24.9028 11.3646 25.25H2.83331ZM12 4.16666C12.2847 4.16666 12.5295 4.06423 12.7344 3.85938C12.9392 3.6545 13.0417 3.40971 13.0417 3.125C13.0417 2.84027 12.9392 2.59548 12.7344 2.39062C12.5295 2.18575 12.2847 2.08331 12 2.08331C11.7153 2.08331 11.4705 2.18575 11.2656 2.39062C11.0608 2.59548 10.9583 2.84027 10.9583 3.125C10.9583 3.40971 11.0608 3.6545 11.2656 3.85938C11.4705 4.06423 11.7153 4.16666 12 4.16666ZM5.75 9.83331V7.75H18.25V9.83331H5.75ZM5.75 15.0417V12.9583H18.25V14.3333C18.1528 14.3958 18.0538 14.4705 17.9531 14.5573C17.8524 14.6441 17.7535 14.7361 17.6562 14.8333L17.4479 15.0417H5.75ZM5.75 20.25V18.1667H14.3229L12.9375 19.5521C12.8125 19.6771 12.7031 19.7934 12.6094 19.901C12.5156 20.0087 12.4236 20.125 12.3333 20.25H5.75Z" fill="#3557FF"></path></svg></span>Interactions <span class="question-mark-cont"><svg class="question-mark" width="14" height="14" viewbox="0 0 14 14" fill="currentColor" xmlns="https://www.w3.org/2000/svg"><path d="M5.99842 10C6.19393 10 6.35975 9.9325 6.49586 9.79746C6.63197 9.66252 6.70002 9.49724 6.70002 9.30163C6.70002 9.10611 6.6325 8.9403 6.49746 8.80419C6.36252 8.66808 6.19724 8.60002 6.00163 8.60002C5.80611 8.60002 5.6403 8.66754 5.50419 8.80259C5.36808 8.93753 5.30002 9.10281 5.30002 9.29842C5.30002 9.49393 5.36755 9.65975 5.50259 9.79586C5.63753 9.93197 5.80281 10 5.99842 10ZM6.00411 12.1C5.23333 12.1 4.50766 11.9542 3.82711 11.6625C3.14655 11.3709 2.55107 10.9698 2.04065 10.4594C1.53023 9.94898 1.12919 9.35369 0.837524 8.67352C0.545858 7.99336 0.400024 7.26662 0.400024 6.49332C0.400024 5.72001 0.545858 4.99551 0.837524 4.31982C1.12919 3.64412 1.53023 3.05107 2.04065 2.54065C2.55107 2.03023 3.14636 1.62919 3.82652 1.33752C4.50669 1.04586 5.23343 0.900024 6.00673 0.900024C6.78004 0.900024 7.50454 1.04586 8.18023 1.33752C8.85593 1.62919 9.44898 2.03023 9.9594 2.54065C10.4698 3.05107 10.8709 3.64519 11.1625 4.32302C11.4542 5.00095 11.6 5.72526 11.6 6.49594C11.6 7.26672 11.4542 7.99238 11.1625 8.67294C10.8709 9.3535 10.4698 9.94898 9.9594 10.4594C9.44898 10.9698 8.85486 11.3709 8.17702 11.6625C7.49909 11.9542 6.77479 12.1 6.00411 12.1ZM6.00002 11.05C7.26391 11.05 8.33822 10.6077 9.22294 9.72294C10.1077 8.83822 10.55 7.76391 10.55 6.50002C10.55 5.23614 10.1077 4.16183 9.22294 3.27711C8.33822 2.39239 7.26391 1.95002 6.00002 1.95002C4.73614 1.95002 3.66183 2.39239 2.77711 3.27711C1.89239 4.16183 1.45002 5.23614 1.45002 6.50002C1.45002 7.76391 1.89239 8.83822 2.77711 9.72294C3.66183 10.6077 4.73614 11.05 6.00002 11.05ZM6.04713 3.99169C6.2932 3.99169 6.50728 4.07049 6.68938 4.22809C6.87148 4.38559 6.96252 4.58251 6.96252 4.81886C6.96252 5.03547 6.89933 5.22641 6.77294 5.39169C6.64655 5.55697 6.50072 5.70766 6.33544 5.84377C6.11183 6.03822 5.91252 6.25697 5.73752 6.50002C5.56252 6.74308 5.47989 7.0153 5.48961 7.31669C5.48961 7.4528 5.53861 7.56218 5.63661 7.64482C5.73461 7.72745 5.84894 7.76877 5.97961 7.76877C6.11961 7.76877 6.23822 7.72745 6.33544 7.64482C6.43266 7.56218 6.49586 7.4528 6.52502 7.31669C6.57364 7.1028 6.666 6.914 6.80211 6.75027C6.93822 6.58645 7.08405 6.43012 7.23961 6.28127C7.46322 6.06739 7.64551 5.82919 7.78648 5.56669C7.92745 5.30419 7.99794 5.02225 7.99794 4.72086C7.99794 4.22502 7.80593 3.81426 7.4219 3.48857C7.03787 3.16287 6.58136 3.00002 6.05238 3.00002C5.68692 3.00002 5.34134 3.08023 5.01565 3.24065C4.68995 3.40107 4.42911 3.63814 4.23311 3.95188C4.15689 4.06592 4.13579 4.191 4.16982 4.32711C4.20384 4.46322 4.28405 4.56044 4.41044 4.61877C4.54655 4.68683 4.68266 4.70141 4.81877 4.66252C4.95489 4.62364 5.06669 4.55072 5.15419 4.44377C5.26114 4.30766 5.39239 4.19829 5.54794 4.11565C5.7035 4.03301 5.86989 3.99169 6.04713 3.99169Z" fill="currentColor"></path></svg></span></h2><div><div class="vitamins-monograph-content interactions-content"><ul><h3>Moderate Interaction</h3><p data-interactions-content="0"> Be cautious with this combination </p><li data-interactions="0"><h3 class="interactions-header">Medications for cancer (Antitumor antibiotics) interacts with ALPHA-LIPOIC ACID</h3><p data-interactions-content="1">Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.</p></li><li data-interactions="1"><h3 class="interactions-header">Thyroid hormone interacts with ALPHA-LIPOIC ACID</h3><p data-interactions-content="2">Alpha-lipoic acid seems to decrease how well thyroid hormone works in the body. Taking alpha-lipoic acid with thyroid hormone might decrease the effects of the thyroid hormone.</p></li><li data-interactions="2"><h3 class="interactions-header">Medications for cancer (Alkylating Agents) interacts with ALPHA-LIPOIC ACID</h3><p data-interactions-content="3">Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.</p></li><li data-interactions="3"><h3 class="interactions-header">Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with ALPHA-LIPOIC ACID</h3><p data-interactions-content="4">Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.</p></li></ul><ul><h3>Minor Interaction</h3><p data-interactions-content="5"> Be watchful with this combination </p><li data-interactions="4"><h3 class="interactions-header">Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID</h3><p data-interactions-content="6">Alpha-lipoic acid might lower blood sugar levels. Taking alpha-lipoic acid along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.</p></li></ul></div></div><div class="interactions-ad mobile-ad mobile-ads-holder"><span></span></div><div class="fifth-para-ad ads-loaded mobile-ads-holder"><span></span></div><div class="webmd-dialog__wrapper" style="display:none;"><div class="webmd-dialog webmd-dialog--center pop-over-dialog-interactions" style="margin-top:15vh;"><div class="webmd-dialog__header"><span class="webmd-dialog__title"></span><button type="button" class="webmd-dialog__headerbtn" aria-label="Close"><i class="webmd-dialog__close webmd-icon webmd-icon-close"></i></button></div></div></div></div><div class="dosing-page center-content tab-content" id="dosing-container"><h2 class="vitamins-monograph-content-headline"><span><svg width="25" height="27" viewbox="0 0 25 27" fill="none" xmlns="https://www.w3.org/2000/svg"><path d="M7.7923 26.125L5.70898 24.5625V19.0417H4.0423C3.4798 19.0417 2.99195 18.8351 2.57877 18.4219C2.16558 18.0087 1.95898 17.5208 1.95898 16.9583V7.16666H1.75064C1.45549 7.16666 1.2081 7.06648 1.00845 6.86613C0.808807 6.66577 0.708984 6.41751 0.708984 6.12134C0.708984 5.82518 0.808807 5.57814 1.00845 5.38022C1.2081 5.1823 1.45549 5.08334 1.75064 5.08334H5.70898V2.58331H4.87564C4.5805 2.58331 4.3331 2.48314 4.13345 2.28278C3.93381 2.08243 3.83398 1.83417 3.83398 1.538C3.83398 1.24183 3.93381 0.994792 4.13345 0.796875C4.3331 0.598958 4.5805 0.5 4.87564 0.5H8.62564C8.92079 0.5 9.16818 0.600177 9.36783 0.800531C9.56747 1.00089 9.6673 1.24915 9.6673 1.54531C9.6673 1.84148 9.56747 2.08852 9.36783 2.28644C9.16818 2.48435 8.92079 2.58331 8.62564 2.58331H7.7923V5.08334H11.7506C12.0458 5.08334 12.2932 5.18352 12.4928 5.38387C12.6925 5.58423 12.7923 5.83249 12.7923 6.12866C12.7923 6.42482 12.6925 6.67186 12.4928 6.86978C12.2932 7.0677 12.0458 7.16666 11.7506 7.16666H11.5423V16.9583C11.5423 17.5208 11.3357 18.0087 10.9225 18.4219C10.5093 18.8351 10.0215 19.0417 9.45898 19.0417H7.7923V26.125ZM4.0423 16.9583H9.45898V14.6667H7.06314C6.8687 14.6667 6.69857 14.5937 6.55273 14.4479C6.4069 14.3021 6.33398 14.1319 6.33398 13.9375C6.33398 13.7431 6.4069 13.5729 6.55273 13.4271C6.69857 13.2813 6.8687 13.2083 7.06314 13.2083H9.45898V10.9167H7.06314C6.8687 10.9167 6.69857 10.8437 6.55273 10.6979C6.4069 10.5521 6.33398 10.3819 6.33398 10.1875C6.33398 9.99306 6.4069 9.82293 6.55273 9.67709C6.69857 9.53126 6.8687 9.45834 7.06314 9.45834H9.45898V7.16666H4.0423V16.9583ZM16.7506 25.5C16.1881 25.5 15.7003 25.2934 15.2871 24.8802C14.8739 24.467 14.6673 23.9792 14.6673 23.4167V15.1667C14.6673 14.5209 14.7576 14.0174 14.9381 13.6563C15.1187 13.2951 15.3375 12.9688 15.5944 12.6771C15.9347 12.3021 16.1777 12.0087 16.3236 11.7969C16.4694 11.5851 16.5423 11.3611 16.5423 11.125V10.2917H16.334C16.0388 10.2917 15.7914 10.1915 15.5918 9.99113C15.3922 9.79077 15.2923 9.54251 15.2923 9.24634C15.2923 8.95018 15.3948 8.70314 15.5996 8.50522C15.8045 8.3073 16.0493 8.20834 16.334 8.20834H22.584C22.8791 8.20834 23.1265 8.30852 23.3262 8.50887C23.5258 8.70923 23.6256 8.95749 23.6256 9.25366C23.6256 9.54982 23.5258 9.79687 23.3262 9.99478C23.1265 10.1927 22.8791 10.2917 22.584 10.2917H22.3756V11.125C22.3756 11.3472 22.4624 11.5833 22.636 11.8333C22.8097 12.0833 23.0701 12.3958 23.4173 12.7708C23.6743 13.0625 23.8774 13.3785 24.0267 13.7188C24.176 14.059 24.2506 14.5417 24.2506 15.1667V23.4167C24.2506 23.9792 24.044 24.467 23.6309 24.8802C23.2177 25.2934 22.7298 25.5 22.1673 25.5H16.7506ZM16.7506 15.9167H22.1673V15.1667C22.1673 14.8125 22.0666 14.5 21.8652 14.2292C21.6638 13.9583 21.4416 13.6736 21.1986 13.375C20.9138 13.0208 20.6916 12.6771 20.5319 12.3438C20.3722 12.0104 20.2923 11.6042 20.2923 11.125V10.2917H18.6256V11.125C18.6256 11.5833 18.551 11.9792 18.4017 12.3125C18.2524 12.6458 18.0354 12.9896 17.7506 13.3438C17.5076 13.6424 17.2802 13.9323 17.0684 14.2135C16.8565 14.4948 16.7506 14.8125 16.7506 15.1667V15.9167ZM16.7506 19.6667H22.1673V17.375H16.7506V19.6667ZM16.7506 23.4167H22.1673V21.125H16.7506V23.4167Z" fill="#3557FF"></path></svg></span>Dosing </h2><div><div class="vitamins-monograph-content dosage-content">Alpha-lipoic acid has most often been used by adults in doses of 600-1800 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.</div></div><div class="dosing-ad mobile-ad mobile-ads-holder"><span></span></div><div class="fifth-para-ad ads-loaded mobile-ads-holder"><span></span></div></div><div class="section-content-holder"><div class="view-ref-container"><a class="view-ref" tabindex="0"> View References </a><div class="pop-up" style="display:none;"><label class="ref-heading"> REFERENCES: </label><span class="close-popup"></span><div><p class="references">Al'-Zamil', M. K. and Brezheva, E. V. [Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(2):27-30. View abstract.</p><p class="references">Bailey, D. M. and Davies, B. Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude. High Alt Med Biol 2001;2(1):21-29. View abstract.</p><p class="references">Bangma, H. R., Smit, G. P., Kuks, J. 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Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther 2009;8(4):416-422. View abstract.</p><p class="references">Berkson, B. M., Rubin, D. M., and Berkson, A. J. The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol. Integr.Cancer Ther 2006;5(1):83-89. View abstract.</p><p class="references">Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Muller, M., Wahl, P., Ziegler, R., and Nawroth, P. P. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997;46(9):1481-1490. View abstract.</p><p class="references">Borcea, V., Nourooz-Zadeh, J., Wolff, S. 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F., Varga, F., and Klaassen, C. D. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol Appl Pharmacol 1992;114(1):88-96. View abstract.</p><p class="references">Guais, A., Baronzio, G., Sanders, E., Campion, F., Mainini, C., Fiorentini, G., Montagnani, F., Behzadi, M., Schwartz, L., and Abolhassani, M. Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development: experimental results and case report. Invest New Drugs 2012;30(1):200-211. View abstract.</p><p class="references">Haak, E. S., Usadel, K. H., Kohleisen, M., Yilmaz, A., Kusterer, K., and Haak, T. The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. Microvasc.Res. 1999;58(1):28-34. View abstract.</p><p class="references">Hahm, J. R., Kim, B. J., and Kim, K. W. Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients. J Diabetes Complications 2004;18(2):79-85. View abstract.</p><p class="references">Han, D., Sen, C. K., Roy, S., Kobayashi, M. S., Tritschler, H. J., and Packer, L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 1997;273(5 Pt 2):R1771-R1778. View abstract.</p><p class="references">Handelman, G. J., Han, D., Tritschler, H., and Packer, L. Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochem Pharmacol 5-18-1994;47(10):1725-1730. View abstract.</p><p class="references">Harris, R. A., Nishiyama, S. K., Wray, D. W., Tedjasaputra, V., Bailey, D. M., and Richardson, R. S. The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia. Eur J Appl.Physiol 2009;107(4):445-453. 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Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na(+) + K(+))- and Ca(++)-ATPase activities in high glucose- treated human erythrocytes. Free Radic.Biol.Med 2000;29(11):1122-1128. View abstract.</p><p class="references">Jameel, N. M., Shekhar, M. A., and Vishwanath, B. S. Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity. Life Sci 12-14-2006;80(2):146-153. View abstract.</p><p class="references">Jang, W. G., Kim, H. S., Park, K. G., Park, Y. B., Yoon, K. H., Han, S. W., Hur, S. H., Park, K. S., and Lee, I. K. Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid. Proteomics. 2004;4(11):3383-3393. View abstract.</p><p class="references">Janson, M. Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging. Clin Interv.Aging 2006;1(3):261-265. 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K., Laaksonen, D. E., Roy, S., Hanninen, O., Packer, L., and Sen, C. K. Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary alpha-lipoic acid supplementation. Biochem.Mol.Biol.Int. 1998;46(2):297-306. View abstract.</p><p class="references">Kim, E., Park, D. W., Choi, S. H., Kim, J. J., and Cho, H. S. A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. 2008;28(2):138-146. View abstract.</p><p class="references">Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 2001;50(6):1464-1471. View abstract.</p><p class="references">Kravchuk, IuA, Mekhtiev, S. N., Uspenskii, IuP, Grinevich, V. B., and Koblov, S. 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Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. Support Care Cancer 2022;30(9):7281-92. View abstract.</p><p class="references">Witman M. A., McDaniel J., Fjeldstad A. S., Ives S. J., Zhao J., Nativi J. N., Stehlik J., Wray D. W., Richardson R. S. A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure. Am J Physiol Heart Circ Physiol 2012;303(10):H1237-H1244. View abstract.</p><p class="references">Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract 2013;101(2):99-105. View abstract.</p><p class="references">Yoshida I, Sweetman L, Kulovich S, et al. 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Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month, multicenter, randomized, controlled trial (ALADIN III Study). Diabetes Care 1999;22:1296-301. View abstract.</p><p class="references">Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33. View abstract.</p><p class="references">Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21. View abstract.</p><p class="references">Ziegler D, Schatz H, Conrad F, et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. Diabetes Care 1997;20:369-73. View abstract.</p><p class="references">Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006;29(11):2365-2370. 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href=\"https:\u002F\u002Fimg.webmd.com\u002Fvim\u002Flive\u002Fwebmd\u002Fconsumer_assets\u002Fsite_images\u002Fdrugs\u002Fassets\u002FVitamin-Brandseeker-Desktop-Background-New.jpg\"\u003E","disable_omniture_load":false,"query":{},"jsonld":"{\"@graph\":[{\"@context\":\"https:\u002F\u002Fschema.org\",\"@type\":\"DietarySupplement\",\"name\":\"ALPHA-LIPOIC ACID\",\"description\":\"Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. 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It is also used for obesity , altitude sickness, aging skin , high levels of cholesterol or other fats in the blood , and many other purposes, but there is no good scientific evidence to support many of these other uses. ...\",\"alternateName\":\"A-Lipoic Acid, Acetate Replacing Factor, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque,Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque, Acide 1,2-dithiolane-3-valérique, Acide 5 Valérique (1,2-dithiolan-3-yl), Acide 6,8-dithiooctanoïque, Acide 6,8-Thioctique, Acido Alfa Lipoico, ALA, Biletan, DHLA, Dihydrolipoic Acid, Extrait d'acide Alpha-Lipoïque, Lipoic Acid, Lipoicin, R-ALA, R-Alpha-Lipoic Acid, (+-)-1,2-Dithiolane-3-Pentanoic Acid, (R)-Dithiolane-3-Pentanoic Acid,R, S-Alpha Lipoic Acid, (R)-Lipoic Acid, R-Lipoic Acid, RS-Alpha-Lipoic Acid, S-Alpha-Lipoic Acid, S-Lipoic Acid, Sodium-R-Lipoate, Thioctacid, Thioctan,Thioctic Acid.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E\"}]}","canonicalurl":"https:\u002F\u002Fwww.webmd.com\u002Fvitamins\u002Fai\u002Fingredientmono-767\u002Falpha-lipoic-acid","rootClasses":{}},"vitamins_data":{"related_treatments_mvs":["{\"Title\":\"Are You at Risk for Diabetic Macular Edema?\",\"Url\":\"https:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fvideo\u002Fdme-risk\",\"Order\":\"1\"}","{\"Title\":\"Should You Change Your Type 2 Diabetes Medication?\",\"Url\":\"https:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fchange-type-2-diabetes-meds\",\"Order\":\"7\"}","{\"Title\":\"Type 2 Diabetes Management Tips\",\"Url\":\"https:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Ftype-2-diabetes\",\"Order\":\"2\"}"],"Clinical_References_mvs":["Al'-Zamil', M. K. and Brezheva, E. V. [Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(2):27-30. View abstract.","Bailey, D. M. and Davies, B. Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude. High Alt Med Biol 2001;2(1):21-29. View abstract.","Bangma, H. R., Smit, G. P., Kuks, J. B., Grevink, R. G., and Wolffenbuttel, B. H. [Two patients with mitochondrial respiratory chain disease]. Ned.Tijdschr.Geneeskd. 10-18-2008;152(42):2298-2301. View abstract.","Bartlett, H. E. and Eperjesi, F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt. 2008;28(6):503-523. View abstract.","Becker, S., Schmidt, C., Berghaus, A., Tschiesner, U., Olzowy, B., and Reichel, O. Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study. Eur Arch.Otorhinolaryngol. 2011;268(9):1375-1381. View abstract.","Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O. Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream. Contact Dermatitis 2006;55(1):56-57. View abstract.","Berkson, B. M., Rubin, D. M., and Berkson, A. J. Revisiting the ALA\u002FN (alpha-lipoic acid\u002Flow-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther 2009;8(4):416-422. View abstract.","Berkson, B. M., Rubin, D. M., and Berkson, A. J. The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid\u002Flow-dose naltrexone protocol. Integr.Cancer Ther 2006;5(1):83-89. View abstract.","Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Muller, M., Wahl, P., Ziegler, R., and Nawroth, P. P. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997;46(9):1481-1490. View abstract.","Borcea, V., Nourooz-Zadeh, J., Wolff, S. P., Klevesath, M., Hofmann, M., Urich, H., Wahl, P., Ziegler, R., Tritschler, H., Halliwell, B., and Nawroth, P. P. alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic.Biol.Med. 1999;22(11-12):1495-1500. View abstract.","Bregovskii, V. B., Posokhina, O. V., and Karpova, I. A. [Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs]. Ter.Arkh. 2005;77(10):15-19. View abstract.","Breithaupt-Grogler, K., Niebch, G., Schneider, E., Erb, K., Hermann, R., Blume, H. H., Schug, B. S., and Belz, G. G. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci 1999;8(1):57-65. View abstract.","Bruckner, I., Bustan, C., Adamescu, E., and Dobjanschi, C. Diabetic neuropathy--choices of treatment. Rom.J Intern Med 2002;40(1-4):53-60. View abstract.","Byun, C. H., Koh, J. M., Kim, D. K., Park, S. I., Lee, K. U., and Kim, G. S. alpha-Lipoic Acid Inhibits TNF-alpha-Induced Apoptosis in Human Bone Marrow Stromal Cells. J Bone Miner.Res 2005;20(7):1125-1135. View abstract.","Cagini, C., Leontiadis, A., Ricci, M. A., Bartolini, A., Dragoni, A., and Pellegrino, R. M. Study of alpha-lipoic acid penetration in the human aqueous after topical administration. Clin Experiment.Ophthalmol. 2010;38(6):572-576. View abstract.","Chaparro, L. E., Wiffen, P. J., Moore, R. A., and Gilron, I. Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database.Syst.Rev. 2012;7:CD008943. View abstract.","Chen LY, Zhang YD & Zhu FY. Effects of alpha lipoic acid and prostaglandin E1 on diabetic peripheral neuropathy. Journal of Practical Diabetology 2008;4:50-51.","Constantinescu, A., Pick, U., Handelman, G. J., Haramaki, N., Han, D., Podda, M., Tritschler, H. J., and Packer, L. Reduction and transport of lipoic acid by human erythrocytes. Biochem.Pharmacol. 7-17-1995;50(2):253-261. View abstract.","de, Moraes M., do Amaral Bezerra, B. A., da Rocha Neto, P. C., de Oliveira Soares, A. C., Pinto, L. P., and de Lisboa Lopes, Costa A. Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature. J Oral Pathol.Med. 2012;41(4):281-287. View abstract.","Doggrell, S. A. Alpha-lipoic acid, an anti-obesity agent? Expert.Opin.Investig.Drugs 2004;13(12):1641-1643. View abstract.","Dunschede, F., Erbes, K., Kircher, A., Westermann, S., Seifert, J., Schad, A., Oliver, K., Kiemer, A. K., and Theodor, J. Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans. World J Gastroenterol 11-14-2006;12(42):6812-6817. View abstract.","Eremeeva, M. E. and Silverman, D. J. Effects of the antioxidant alpha-lipoic acid on human umbilical vein endothelial cells infected with Rickettsia rickettsii. Infect.Immun. 1998;66(5):2290-2299. View abstract.","Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., and Klip, A. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid\u002Fthioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-1804. View abstract.","Evans, J. L., Heymann, C. J., Goldfine, I. D., and Gavin, L. A. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Endocr.Pract. 2002;8(1):29-35. View abstract.","Evans, JL and Goldfine, ID. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technology and Therapeutics 2000;2(3):401-413.","Fedin, A. I., Kuznetsov, M. R., Beresten', N. F., Kuznetsova, V. F., Kholopova, E. A., Ibragimov, T. M., Tugdumov, B. V., and Dubrovin, E. E. [Correction of disordered cerebral blood flow autoregulation in atherosclerosis]. Angiol.Sosud.Khir. 2009;15(3):21-26. View abstract.","Femiano, F. Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies. Minerva Stomatol. 2002;51(9):405-409. View abstract.","Fu Y. Effects of alpha lipoic acid and mecobalamin on diabetic peripheral neuropathy. Chinese Journal of Practical Internal Medicine. 2008;28:81-83.","Ghibu, S., Richard, C., Delemasure, S., Vergely, C., Mogosan, C., and Muresan, A. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. Ann Cardiol.Angeiol.(Paris) 2008;57(3):161-165. View abstract.","Gianturco, V., Bellomo, A., D'Ottavio, E., Formosa, V., Iori, A., Mancinella, M., Troisi, G., and Marigliano, V. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction? Arch.Gerontol.Geriatr. 2009;49 Suppl 1:129-133. View abstract.","Gleiter, C. H., Schug, B. S., Hermann, R., Elze, M., Blume, H. H., and Gundert-Remy, U. Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur.J Clin Pharmacol. 1996;50(6):513-514. View abstract.","Gregus, Z., Stein, A. F., Varga, F., and Klaassen, C. D. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol Appl Pharmacol 1992;114(1):88-96. View abstract.","Guais, A., Baronzio, G., Sanders, E., Campion, F., Mainini, C., Fiorentini, G., Montagnani, F., Behzadi, M., Schwartz, L., and Abolhassani, M. Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development: experimental results and case report. Invest New Drugs 2012;30(1):200-211. View abstract.","Haak, E. S., Usadel, K. H., Kohleisen, M., Yilmaz, A., Kusterer, K., and Haak, T. The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. Microvasc.Res. 1999;58(1):28-34. View abstract.","Hahm, J. R., Kim, B. J., and Kim, K. W. Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients. J Diabetes Complications 2004;18(2):79-85. View abstract.","Han, D., Sen, C. K., Roy, S., Kobayashi, M. S., Tritschler, H. J., and Packer, L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 1997;273(5 Pt 2):R1771-R1778. View abstract.","Handelman, G. 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J Appl.Physiol 1999;86(4):1191-1196. View abstract.","Khanna, S., Atalay, M., Lodge, J. K., Laaksonen, D. E., Roy, S., Hanninen, O., Packer, L., and Sen, C. K. Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary alpha-lipoic acid supplementation. Biochem.Mol.Biol.Int. 1998;46(2):297-306. View abstract.","Kim, E., Park, D. W., Choi, S. H., Kim, J. J., and Cho, H. S. A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. 2008;28(2):138-146. View abstract.","Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 2001;50(6):1464-1471. View abstract.","Kravchuk, IuA, Mekhtiev, S. N., Uspenskii, IuP, Grinevich, V. 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I., Freeman R., Samigullin R., Tritschler H., Munzel U., Maus J., Schütte K., Dyck P. J. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care 2011;34(9):2054-2060. View abstract.","Abdelrahman KA, Ibrahim AS, Osman AM, Aly MG, Ali AS, Farrag WS. Alpha lipoic acid with pulsed radiofrequency in treatment of chronic lumbosacral radicular pain: A prospective, randomized study. Medicine (Baltimore) 2021;100(24):e26344. View abstract.","Abu-Zaid A, Baradwan S, Bukhari IA, et al. The effect of alpha-lipoic acid supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in individuals with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials. Obstet Gynecol Sci 2023. View abstract.","Ahmadi M, Keshavarz SA, Abbasi B. Effects of alpha lipoic acid supplementation on serum lipid profile in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial. ARYA Atheroscler 2022;18(4):1-8. View abstract.","Alleva R., Nasole E., Di Donato F., Borghi B., Neuzil J., Tomasetti M. alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun 2005;333(2):404-410. View abstract.","Alleva R., Tomasetti M., Sartini D., Emanuelli M., Nasole E., Di Donato F., Borghi B., Santarelli L., Neuzil J. alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy. Mol Med 2008;14(3-4):175-183. View abstract.","Altenkirch H, Stoltenburg-Didinger G, Wagner HM, et al. Effects of lipoic acid in hexacarbon-induced neuropathy. Neurotoxicol Teratol 1990;12:619-22. View abstract.","Altunina N, Bondarchuk O. 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N., Stehlik J., Wray D. W., Richardson R. S. A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure. Am J Physiol Heart Circ Physiol 2012;303(10):H1237-H1244. View abstract.","Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract 2013;101(2):99-105. View abstract.","Yoshida I, Sweetman L, Kulovich S, et al. Effect of lipoic acid in patient with defective activity of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase, and branched-chain keto acid dehydrogenase. Pediatr Res 1990;27:75-9. View abstract.","Yousefi M, Kavianpour M, Hesami S, Rashidi Nooshabadi M, Khadem Haghighian H. Effect of alpha-lipoic acid at the combination with mefenamic acid in girls with primary dysmenorrhea: randomized, double-blind, placebo-controlled clinical trial. Gynecol Endocrinol. 2019;35(9):782-786. View abstract.","Yukina M, Nuralieva N, Solovyev M, Troshina E, Vasilyev E. Insulin autoimmune syndrome. Endocrinol Diabetes Metab Case Rep. 2020;2020:19-0159. View abstract.","Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., Stefaniak, T., and Dziubek, W. Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol. 2009;60(2):139-143. View abstract.","Zhang L, Zhang HY, Huang FC, Huang Q, Liu C, Li JR. Study on the clinical value of alprostadil combined with alpha-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction. Eur Rev Med Pharmacol Sci. 2016 Sep;20(18):3930-33. View abstract.","Zhang Y., Han P., Wu N., He B., Lu Y., Li S., Liu Y., Zhao S., Liu L., Li Y. Amelioration of lipid abnormalities by a-lipoic acid through antioxidative and anti-inflammatory effects. Obesity (Silver Spring) 2011;19(8):1647-1653. View abstract.","Zhang, W. J., Wei, H., Hagen, T., and Frei, B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase\u002FAkt signaling pathway. Proc Natl Acad Sci U.S.A 3-6-2007;104(10):4077-4082. View abstract.","Ziegler D, Hanefeld M, Ruhnau K, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month, multicenter, randomized, controlled trial (ALADIN III Study). Diabetes Care 1999;22:1296-301. View abstract.","Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33. View abstract.","Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21. View abstract.","Ziegler D, Schatz H, Conrad F, et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. Diabetes Care 1997;20:369-73. View abstract.","Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006;29(11):2365-2370. 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[{\"@context\":\"https:\u002F\u002Fschema.org\",\"@type\":\"DietarySupplement\",\"name\":\"ALPHA-LIPOIC ACID\",\"description\":\"Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy. Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in supplements . Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases . People most commonly use alpha-lipoic acid for nerve pain in people with diabetes. It is also used for obesity , altitude sickness, aging skin , high levels of cholesterol or other fats in the blood , and many other purposes, but there is no good scientific evidence to support many of these other uses. ...\",\"alternateName\":\"A-Lipoic Acid, Acetate Replacing Factor, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque,Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque, Acide 1,2-dithiolane-3-valérique, Acide 5 Valérique (1,2-dithiolan-3-yl), Acide 6,8-dithiooctanoïque, Acide 6,8-Thioctique, Acido Alfa Lipoico, ALA, Biletan, DHLA, Dihydrolipoic Acid, Extrait d'acide Alpha-Lipoïque, Lipoic Acid, Lipoicin, R-ALA, R-Alpha-Lipoic Acid, (+-)-1,2-Dithiolane-3-Pentanoic Acid, (R)-Dithiolane-3-Pentanoic Acid,R, S-Alpha Lipoic Acid, (R)-Lipoic Acid, R-Lipoic Acid, RS-Alpha-Lipoic Acid, S-Alpha-Lipoic Acid, S-Lipoic Acid, Sodium-R-Lipoate, Thioctacid, Thioctan,Thioctic Acid.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E\"}]} }"],"content":["{\"title\":\"ALPHA-LIPOIC ACID\",\"OtherNames\":\"A-Lipoic Acid, Acetate Replacing Factor, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque,Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque, Acide 1,2-dithiolane-3-valérique, Acide 5 Valérique (1,2-dithiolan-3-yl), Acide 6,8-dithiooctanoïque, Acide 6,8-Thioctique, Acido Alfa Lipoico, ALA, Biletan, DHLA, Dihydrolipoic Acid, Extrait d'acide Alpha-Lipoïque, Lipoic Acid, Lipoicin, R-ALA, R-Alpha-Lipoic Acid, (+-)-1,2-Dithiolane-3-Pentanoic Acid, (R)-Dithiolane-3-Pentanoic Acid,R, S-Alpha Lipoic Acid, (R)-Lipoic Acid, R-Lipoic Acid, RS-Alpha-Lipoic Acid, S-Alpha-Lipoic Acid, S-Lipoic Acid, Sodium-R-Lipoate, Thioctacid, Thioctan,Thioctic Acid.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E\",\"SearchString\":\"\\\"(+-)-1,2-Dithiolane-3-Pentanoic Acid\\\" or \\\"(R)-Dithiolane-3-Pentanoic Acid\\\" or \\\"(R)-Lipoic Acid\\\" or \\\"A-Lipoic Acid\\\" or \\\"Acetate Replacing Factor\\\" or \\\"Acide 1,2-dithiolane-3-pentanoïque\\\" or \\\"Acide 1,2-dithiolane-3-valérique\\\" or \\\"Acide 5 Valérique (1,2-dithiolan-3-yl)\\\" or \\\"Acide 6,8-dithiooctanoïque\\\" or \\\"Acide 6,8-Thioctique\\\" or \\\"Acide Alpha-Lipoïque\\\" or \\\"Acide Alpha-Lipoïque R\\\" or \\\"Acide DL-Alpha-Lipoïque\\\" or \\\"Acide Lipoïque\\\" or \\\"Acide Thioctique\\\" or \\\"Acido Alfa Lipoico\\\" or \\\"ALA\\\" or \\\"Alpha Lipoic Acid; 1,2-dithiolane-3-pentanoic acid; 1,2-dithiolane-3-valeri\\\" or \\\"Alpha-Lipoic Acid\\\" or \\\"Biletan\\\" or \\\"DHLA\\\" or \\\"Dihydrolipoic acid\\\" or \\\"Extrait d'acide Alpha-Lipoïque\\\" or \\\"Lipoic Acid\\\" or \\\"Lipoicin\\\" or \\\"R, S-Alpha Lipoic Acid\\\" or \\\"R-ALA\\\" or \\\"R-Alpha-Lipoic Acid\\\" or \\\"R-Lipoic Acid\\\" or \\\"RS-Alpha-Lipoic Acid\\\" or \\\"S-Alpha-Lipoic Acid\\\" or \\\"S-Lipoic Acid\\\" or \\\"Sodium-R-Lipoate\\\" or \\\"Thioctacid\\\" or \\\"Thioctan\\\" or \\\"Thioctic Acid\\\"\",\"AdditionalTerms\":\"\",\"EnCDrugInteractions\":\"Medications for cancer (Alkylating Agents): Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.\u003Cbr\u003E Medications for cancer (Antitumor antibiotics): Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.\u003Cbr\u003E Medications that slow blood clotting (Anticoagulant \u002F Antiplatelet drugs): Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.\u003Cbr\u003E Thyroid hormone: Alpha-lipoic acid seems to decrease how well thyroid hormone works in the body. Taking alpha-lipoic acid with thyroid hormone might decrease the effects of the thyroid hormone.\u003Cbr\u003E Medications for diabetes (Antidiabetes drugs): Alpha-lipoic acid might lower blood sugar levels. Taking alpha-lipoic acid along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.\",\"EnCHerbInteractions\":\"Herbs and supplements that might lower blood sugar: Alpha-lipoic acid might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.\u003Cbr\u003E Herbs and supplements that might slow blood clotting: Alpha-lipoic acid might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.\u003Cbr\u003E Herbs with thyroid activity: Alpha lipoic acid might affect the body's production of thyroid hormone. Taking it with other supplements with similar effects might alter thyroid function too much and cause side effects. Examples of supplements with this effect include bugleweed, lemon balm, and tiratricol.\",\"EnCFoodInteractions\":\"There are no known interactions with foods.\",\"Dosage\":\"Alpha-lipoic acid has most often been used by adults in doses of 600-1800 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.\",\"EnCApplied\":\"\",\"Effective\":\"\",\"InEffective\":\"\",\"InsufficientEvidence\":\"\",\"LikelyEffective\":\"\",\"LikelyInEffective\":\"\",\"PossiblyEffective\":\"\u003Cul\u003E \u003Cli\u003E\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fpain-management\u002Fvideo\u002Fdiagnosing-treating-nerve-pain\\\" crossLinkId=\\\"1596825\\\" keywordSetId=\\\"10418\\\" externalId=\\\"091e9c5e804bb184\\\" keywordId=\\\"42698\\\" chronic_id=\\\"091e9c5e804bb184\\\" crossLinkType=\\\"Video\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003ENerve pain\u003C\u002Fa\u003E in people with diabetes (\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fdiabetes-neuropathy\\\" crossLinkId=\\\"1582687\\\" keywordSetId=\\\"8581\\\" externalId=\\\"091e9c5e80008426\\\" keywordId=\\\"33971\\\" chronic_id=\\\"091e9c5e80008426\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ediabetic neuropathy\u003C\u002Fa\u003E). Taking 600-1800 mg of alpha-lipoic acid by \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Foral-health\u002Fss\u002Fslideshow-mouth-problems\\\" crossLinkId=\\\"1624516\\\" keywordSetId=\\\"40982\\\" externalId=\\\"091e9c5e802bb621\\\" keywordId=\\\"93494\\\" chronic_id=\\\"091e9c5e802bb621\\\" crossLinkType=\\\"Slideshows\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Emouth\u003C\u002Fa\u003E or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. Lower doses of alpha-lipoic acid don't seem to work. IV products can only be given by a \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fhealth-insurance\u002Frm-quiz-insurance-basics\\\" crossLinkId=\\\"1619843\\\" keywordSetId=\\\"33248\\\" externalId=\\\"091e9c5e80cee26e\\\" keywordId=\\\"73362\\\" chronic_id=\\\"091e9c5e80cee26e\\\" crossLinkType=\\\"Tools\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ehealthcare\u003C\u002Fa\u003E provider.\u003C\u002Fli\u003E \u003Cli\u003EHigh levels of cholesterol or other fats (\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Ftests-for-high-cholesterol-lipid-panel\\\" crossLinkId=\\\"59018\\\" keywordSetId=\\\"49961\\\" externalId=\\\"091e9c5e8028abb6\\\" keywordId=\\\"114556\\\" chronic_id=\\\"091e9c5e8028abb6\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Elipids\u003C\u002Fa\u003E) in the blood (\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Fhyperlipidemia-overview\\\" crossLinkId=\\\"1899328\\\" keywordSetId=\\\"47197\\\" externalId=\\\"091e9c5e813edc56\\\" keywordId=\\\"108779\\\" chronic_id=\\\"091e9c5e813edc56\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ehyperlipidemia\u003C\u002Fa\u003E). Taking alpha-lipoic acid by \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Foral-health\u002Frm-quiz-mouth-myths\\\" crossLinkId=\\\"1619208\\\" keywordSetId=\\\"40982\\\" externalId=\\\"091e9c5e80d71be5\\\" keywordId=\\\"93494\\\" chronic_id=\\\"091e9c5e80d71be5\\\" crossLinkType=\\\"Tools\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Emouth\u003C\u002Fa\u003E for up to 4 years seems to lower \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Funderstanding-numbers\\\" crossLinkId=\\\"8342\\\" keywordSetId=\\\"8382\\\" externalId=\\\"091e9c5e800081fd\\\" keywordId=\\\"108937\\\" chronic_id=\\\"091e9c5e800081fd\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Etotal cholesterol\u003C\u002Fa\u003E and low-density lipoprotein (\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fheart-disease\u002Fldl-cholesterol-the-bad-cholesterol\\\" crossLinkId=\\\"59022\\\" keywordSetId=\\\"1461\\\" externalId=\\\"091e9c5e8028aaf6\\\" keywordId=\\\"42789\\\" chronic_id=\\\"091e9c5e8028aaf6\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003ELDL\u003C\u002Fa\u003E or \\\"bad\\\") cholesterol in people with or without hyperlipidemia.\u003C\u002Fli\u003E \u003Cli\u003EObesity. Taking alpha-lipoic acid by mouth can slightly reduce \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fobesity\u002Fhealthy-weight\\\" crossLinkId=\\\"1903515\\\" keywordSetId=\\\"8910\\\" externalId=\\\"091e9c5e816856bb\\\" keywordId=\\\"35915\\\" chronic_id=\\\"091e9c5e816856bb\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ebody weight\u003C\u002Fa\u003E in adults who are overweight. \u003C\u002Fli\u003E\u003C\u002Ful\u003E \",\"PossiblyInEffective\":\"\u003Cul\u003E \u003Cli\u003ELiver disease in people who drink alcohol. Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fhepatitis\u002Fliver-function-test-lft\\\" crossLinkId=\\\"1514148\\\" keywordSetId=\\\"32870\\\" externalId=\\\"091e9c5e8068dce6\\\" keywordId=\\\"72818\\\" chronic_id=\\\"091e9c5e8068dce6\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eliver function\u003C\u002Fa\u003E or reduce \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fdigestive-disorders\u002Fpicture-of-the-liver\\\" crossLinkId=\\\"73851\\\" keywordSetId=\\\"10464\\\" externalId=\\\"091e9c5e80348a30\\\" keywordId=\\\"42791\\\" chronic_id=\\\"091e9c5e80348a30\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eliver\u003C\u002Fa\u003E damage in people with alcohol-related liver disease.\u003C\u002Fli\u003E \u003Cli\u003EAltitude sickness. Taking alpha-lipoic acid by mouth along with \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fvitamins-supplements\u002Fingredientmono-1001-vitamin-c-ascorbic-acid.aspx?activeingredientid=1001&activeingredientname=vitamin-c-(ascorbic-acid)\\\" crossLinkId=\\\"1884444\\\" keywordSetId=\\\"31339\\\" externalId=\\\"1001\\\" keywordId=\\\"69419\\\" chronic_id=\\\"\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Evitamin C\u003C\u002Fa\u003E and \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fvitamins-supplements\u002Fingredientmono-954-vitamin-e.aspx?activeingredientid=954&activeingredientname=vitamin-e\\\" crossLinkId=\\\"1884399\\\" keywordSetId=\\\"41108\\\" externalId=\\\"954\\\" keywordId=\\\"93779\\\" chronic_id=\\\"\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Evitamin E\u003C\u002Fa\u003E does not seem to prevent altitude sickness.\u003C\u002Fli\u003E \u003Cli\u003E\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fkidney-stones\u002Fpicture-of-the-kidneys\\\" crossLinkId=\\\"72677\\\" keywordSetId=\\\"26662\\\" externalId=\\\"091e9c5e803f72c0\\\" keywordId=\\\"60461\\\" chronic_id=\\\"091e9c5e803f72c0\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003EKidney\u003C\u002Fa\u003E damage caused by contrast dyes (contrast induced nephropathy). Taking alpha-lipoic acid by mouth with or without standard \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fa-to-z-guides\u002Fdehydration-adults\\\" crossLinkId=\\\"900\\\" keywordSetId=\\\"1077\\\" externalId=\\\"091e9c5e8000b073\\\" keywordId=\\\"94660\\\" chronic_id=\\\"091e9c5e8000b073\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ehydration\u003C\u002Fa\u003E therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents.\u003C\u002Fli\u003E \u003Cli\u003EDiabetes. Taking alpha-lipoic acid by mouth or by IV does not improve blood sugar levels in people with \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Ftype-2-diabetes\\\" crossLinkId=\\\"1582839\\\" keywordSetId=\\\"2021\\\" externalId=\\\"091e9c5e80010f55\\\" keywordId=\\\"8505\\\" chronic_id=\\\"091e9c5e80010f55\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Etype 2 diabetes\u003C\u002Fa\u003E. \u003C\u002Fli\u003E \u003Cli\u003E\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Feye-health\u002Fvision-basics\\\" crossLinkId=\\\"3407\\\" keywordSetId=\\\"1184\\\" externalId=\\\"091e9c5e800076b7\\\" keywordId=\\\"35136\\\" chronic_id=\\\"091e9c5e800076b7\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003EVision\u003C\u002Fa\u003E problems in people with diabetes (\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fdiabetic-retinopathy\\\" crossLinkId=\\\"1582790\\\" keywordSetId=\\\"8582\\\" externalId=\\\"091e9c5e80007e43\\\" keywordId=\\\"33972\\\" chronic_id=\\\"091e9c5e80007e43\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ediabetic retinopathy\u003C\u002Fa\u003E). Taking alpha-lipoic acid by mouth daily for 24 months doesn't improve \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Feye-health\u002Fpicture-of-the-eyes\\\" crossLinkId=\\\"72347\\\" keywordSetId=\\\"26646\\\" externalId=\\\"091e9c5e803ffc74\\\" keywordId=\\\"60424\\\" chronic_id=\\\"091e9c5e803ffc74\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eeye\u003C\u002Fa\u003E damage from diabetes.\u003C\u002Fli\u003E \u003Cli\u003E\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Falzheimers\u002Ftypes-dementia\\\" crossLinkId=\\\"1218\\\" keywordSetId=\\\"47107\\\" externalId=\\\"091e9c5e80008c55\\\" keywordId=\\\"108635\\\" chronic_id=\\\"091e9c5e80008c55\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003EDementia\u003C\u002Fa\u003E in people with advanced \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fhiv-aids\u002Funderstanding-aids-hiv-basics\\\" crossLinkId=\\\"1565792\\\" keywordSetId=\\\"1340\\\" externalId=\\\"091e9c5e80008960\\\" keywordId=\\\"7583\\\" chronic_id=\\\"091e9c5e80008960\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003EHIV\u003C\u002Fa\u003E\u002FAIDS. Taking alpha-lipoic acid by mouth has no effect on thinking problems in people with HIV.\u003C\u002Fli\u003E \u003Cli\u003EHigh levels of fats called triglycerides in the blood (hypertriglyceridemia). Taking alpha-lipoic acid by mouth doesn't seem to reduce \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Flowering-triglyceride-levels\\\" crossLinkId=\\\"1560504\\\" keywordSetId=\\\"2010\\\" externalId=\\\"091e9c5e8028e149\\\" keywordId=\\\"71913\\\" chronic_id=\\\"091e9c5e8028e149\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Etriglyceride levels\u003C\u002Fa\u003E in most people.\u003C\u002Fli\u003E \u003C\u002Ful\u003E There is interest in using alpha-lipoic acid for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful. \",\"SideEffects\":\"\u003Cb\u003EWhen taken by mouth\u003C\u002Fb\u003E: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting. \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EWhen applied to the skin\u003C\u002Fb\u003E: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people. \u003Ch4\u003ESpecial Precautions & Warnings:\u003C\u002Fh4\u003E \u003Cb\u003EPregnancy\u003C\u002Fb\u003E: When taken by mouth, alpha-lipoic acid is possibly safe. It's been used safely during pregnancy in doses of up to 600 mg daily for up to 4 weeks. \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EBreast-feeding\u003C\u002Fb\u003E: There isn't enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EChildren\u003C\u002Fb\u003E: Alpha-lipoic acid is possibly safe in children aged 10-17 years when taken by mouth in doses up to 600 mg daily for 3 months. But it is possibly unsafe for children to take large amounts of alpha-lipoic acid by mouth. Seizures, vomiting, and unconsciousness have been reported for children aged 14 months to 16 years who took up to 2400 mg of alpha-lipoic acid as a single dose.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003ESurgery\u003C\u002Fb\u003E: Alpha-lipoic acid can decrease blood sugar levels. Alpha-lipoic acid might interfere with blood sugar control during and after surgery. Stop taking alpha-lipoic acid 2 weeks before elective surgical procedures.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EExcessive use of alcohol\u002F\u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fwernicke-korsakoff-syndrome-facts\\\" crossLinkId=\\\"1907340\\\" keywordSetId=\\\"10086\\\" externalId=\\\"091e9c5e818dcd96\\\" keywordId=\\\"41771\\\" chronic_id=\\\"091e9c5e818dcd96\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Ethiamine deficiency\u003C\u002Fa\u003E\u003C\u002Fb\u003E: Alcohol can lower the amount of thiamine (vitamin B1) in the body. Taking alpha-lipoic acid when there is a shortage of thiamine might cause serious health problems. If you drink a lot of alcohol and take alpha-lipoic acid, you should take a thiamine supplement.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \",\"PtEdDescription\":\"Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fmen\u002Fvideo\u002Flamm-supplements-diet\\\" crossLinkId=\\\"1600841\\\" keywordSetId=\\\"9847\\\" externalId=\\\"091e9c5e800ccbab\\\" keywordId=\\\"40266\\\" chronic_id=\\\"091e9c5e800ccbab\\\" crossLinkType=\\\"Video\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Esupplements\u003C\u002Fa\u003E. Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fhepatitis\u002Fliver-and-hepatic-diseases\\\" crossLinkId=\\\"1909768\\\" keywordSetId=\\\"51561\\\" externalId=\\\"091e9c5e81b881fe\\\" keywordId=\\\"118047\\\" chronic_id=\\\"091e9c5e81b881fe\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eliver diseases\u003C\u002Fa\u003E.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E People most commonly use alpha-lipoic acid for \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fnerve-pain-and-nerve-damage-symptoms-and-causes\\\" crossLinkId=\\\"58569\\\" keywordSetId=\\\"10418\\\" externalId=\\\"091e9c5e8027ef13\\\" keywordId=\\\"42698\\\" chronic_id=\\\"091e9c5e8027ef13\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Enerve pain\u003C\u002Fa\u003E in people with diabetes. It is also used for \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fobesity\u002Fvideo\u002Fobesity-risks\\\" crossLinkId=\\\"1542808\\\" keywordSetId=\\\"1635\\\" externalId=\\\"091e9c5e80047f6f\\\" keywordId=\\\"7982\\\" chronic_id=\\\"091e9c5e80047f6f\\\" crossLinkType=\\\"Video\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eobesity\u003C\u002Fa\u003E, altitude sickness, aging \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fskin-problems-and-treatments\u002Fpicture-of-the-skin\\\" crossLinkId=\\\"70837\\\" keywordSetId=\\\"26541\\\" externalId=\\\"091e9c5e80396037\\\" keywordId=\\\"60205\\\" chronic_id=\\\"091e9c5e80396037\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eskin\u003C\u002Fa\u003E, high levels of cholesterol or other fats in the \u003Ca href=\\\"http:\u002F\u002Fwww.webmd.com\u002Fheart\u002Fanatomy-picture-of-blood\\\" crossLinkId=\\\"1506783\\\" keywordSetId=\\\"28544\\\" externalId=\\\"091e9c5e8056ea80\\\" keywordId=\\\"62987\\\" chronic_id=\\\"091e9c5e8056ea80\\\" crossLinkType=\\\"Article\\\" directive=\\\"friendlyurl\\\" object_type=\\\"wbmd_pb_page\\\"\u003Eblood\u003C\u002Fa\u003E, and many other purposes, but there is no good scientific evidence to support many of these other uses. \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \",\"PtEdInteractions\":\"Medications for cancer (Alkylating Agents): Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.\u003Cbr\u003E Medications for cancer (Antitumor antibiotics): Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.\u003Cbr\u003E Medications that slow blood clotting (Anticoagulant \u002F Antiplatelet drugs): Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.\u003Cbr\u003E Thyroid hormone: Alpha-lipoic acid seems to decrease how well thyroid hormone works in the body. Taking alpha-lipoic acid with thyroid hormone might decrease the effects of the thyroid hormone.\u003Cbr\u003E Medications for diabetes (Antidiabetes drugs): Alpha-lipoic acid might lower blood sugar levels. Taking alpha-lipoic acid along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.\",\"PtEdAction\":\"\"}"],"reviews_count":260},"content_data":{"title":"ALPHA-LIPOIC ACID","OtherNames":"A-Lipoic Acid, Acetate Replacing Factor, Acide Alpha-Lipoïque, Acide Alpha-Lipoïque R, Acide DL-Alpha-Lipoïque,Acide Lipoïque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoïque, Acide 1,2-dithiolane-3-valérique, Acide 5 Valérique (1,2-dithiolan-3-yl), Acide 6,8-dithiooctanoïque, Acide 6,8-Thioctique, Acido Alfa Lipoico, ALA, Biletan, DHLA, Dihydrolipoic Acid, Extrait d'acide Alpha-Lipoïque, Lipoic Acid, Lipoicin, R-ALA, R-Alpha-Lipoic Acid, (+-)-1,2-Dithiolane-3-Pentanoic Acid, (R)-Dithiolane-3-Pentanoic Acid,R, S-Alpha Lipoic Acid, (R)-Lipoic Acid, R-Lipoic Acid, RS-Alpha-Lipoic Acid, S-Alpha-Lipoic Acid, S-Lipoic Acid, Sodium-R-Lipoate, Thioctacid, Thioctan,Thioctic Acid.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E","SearchString":"\"(+-)-1,2-Dithiolane-3-Pentanoic Acid\" or \"(R)-Dithiolane-3-Pentanoic Acid\" or \"(R)-Lipoic Acid\" or \"A-Lipoic Acid\" or \"Acetate Replacing Factor\" or \"Acide 1,2-dithiolane-3-pentanoïque\" or \"Acide 1,2-dithiolane-3-valérique\" or \"Acide 5 Valérique (1,2-dithiolan-3-yl)\" or \"Acide 6,8-dithiooctanoïque\" or \"Acide 6,8-Thioctique\" or \"Acide Alpha-Lipoïque\" or \"Acide Alpha-Lipoïque R\" or \"Acide DL-Alpha-Lipoïque\" or \"Acide Lipoïque\" or \"Acide Thioctique\" or \"Acido Alfa Lipoico\" or \"ALA\" or \"Alpha Lipoic Acid; 1,2-dithiolane-3-pentanoic acid; 1,2-dithiolane-3-valeri\" or \"Alpha-Lipoic Acid\" or \"Biletan\" or \"DHLA\" or \"Dihydrolipoic acid\" or \"Extrait d'acide Alpha-Lipoïque\" or \"Lipoic Acid\" or \"Lipoicin\" or \"R, S-Alpha Lipoic Acid\" or \"R-ALA\" or \"R-Alpha-Lipoic Acid\" or \"R-Lipoic Acid\" or \"RS-Alpha-Lipoic Acid\" or \"S-Alpha-Lipoic Acid\" or \"S-Lipoic Acid\" or \"Sodium-R-Lipoate\" or \"Thioctacid\" or \"Thioctan\" or \"Thioctic Acid\"","AdditionalTerms":"","EnCDrugInteractions":"Medications for cancer (Alkylating Agents): Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.\u003Cbr\u003E Medications for cancer (Antitumor antibiotics): Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.\u003Cbr\u003E Medications that slow blood clotting (Anticoagulant \u002F Antiplatelet drugs): Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.\u003Cbr\u003E Thyroid hormone: Alpha-lipoic acid seems to decrease how well thyroid hormone works in the body. Taking alpha-lipoic acid with thyroid hormone might decrease the effects of the thyroid hormone.\u003Cbr\u003E Medications for diabetes (Antidiabetes drugs): Alpha-lipoic acid might lower blood sugar levels. Taking alpha-lipoic acid along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.","EnCHerbInteractions":"Herbs and supplements that might lower blood sugar: Alpha-lipoic acid might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.\u003Cbr\u003E Herbs and supplements that might slow blood clotting: Alpha-lipoic acid might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.\u003Cbr\u003E Herbs with thyroid activity: Alpha lipoic acid might affect the body's production of thyroid hormone. Taking it with other supplements with similar effects might alter thyroid function too much and cause side effects. Examples of supplements with this effect include bugleweed, lemon balm, and tiratricol.","EnCFoodInteractions":"There are no known interactions with foods.","Dosage":"Alpha-lipoic acid has most often been used by adults in doses of 600-1800 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.","EnCApplied":"","Effective":"","InEffective":"","InsufficientEvidence":"","LikelyEffective":"","LikelyInEffective":"","PossiblyEffective":"\u003Cul\u003E \u003Cli\u003E\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fpain-management\u002Fvideo\u002Fdiagnosing-treating-nerve-pain\" crossLinkId=\"1596825\" keywordSetId=\"10418\" externalId=\"091e9c5e804bb184\" keywordId=\"42698\" chronic_id=\"091e9c5e804bb184\" crossLinkType=\"Video\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003ENerve pain\u003C\u002Fa\u003E in people with diabetes (\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fdiabetes-neuropathy\" crossLinkId=\"1582687\" keywordSetId=\"8581\" externalId=\"091e9c5e80008426\" keywordId=\"33971\" chronic_id=\"091e9c5e80008426\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ediabetic neuropathy\u003C\u002Fa\u003E). Taking 600-1800 mg of alpha-lipoic acid by \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Foral-health\u002Fss\u002Fslideshow-mouth-problems\" crossLinkId=\"1624516\" keywordSetId=\"40982\" externalId=\"091e9c5e802bb621\" keywordId=\"93494\" chronic_id=\"091e9c5e802bb621\" crossLinkType=\"Slideshows\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Emouth\u003C\u002Fa\u003E or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. Lower doses of alpha-lipoic acid don't seem to work. IV products can only be given by a \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fhealth-insurance\u002Frm-quiz-insurance-basics\" crossLinkId=\"1619843\" keywordSetId=\"33248\" externalId=\"091e9c5e80cee26e\" keywordId=\"73362\" chronic_id=\"091e9c5e80cee26e\" crossLinkType=\"Tools\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ehealthcare\u003C\u002Fa\u003E provider.\u003C\u002Fli\u003E \u003Cli\u003EHigh levels of cholesterol or other fats (\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Ftests-for-high-cholesterol-lipid-panel\" crossLinkId=\"59018\" keywordSetId=\"49961\" externalId=\"091e9c5e8028abb6\" keywordId=\"114556\" chronic_id=\"091e9c5e8028abb6\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Elipids\u003C\u002Fa\u003E) in the blood (\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Fhyperlipidemia-overview\" crossLinkId=\"1899328\" keywordSetId=\"47197\" externalId=\"091e9c5e813edc56\" keywordId=\"108779\" chronic_id=\"091e9c5e813edc56\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ehyperlipidemia\u003C\u002Fa\u003E). Taking alpha-lipoic acid by \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Foral-health\u002Frm-quiz-mouth-myths\" crossLinkId=\"1619208\" keywordSetId=\"40982\" externalId=\"091e9c5e80d71be5\" keywordId=\"93494\" chronic_id=\"091e9c5e80d71be5\" crossLinkType=\"Tools\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Emouth\u003C\u002Fa\u003E for up to 4 years seems to lower \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Funderstanding-numbers\" crossLinkId=\"8342\" keywordSetId=\"8382\" externalId=\"091e9c5e800081fd\" keywordId=\"108937\" chronic_id=\"091e9c5e800081fd\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Etotal cholesterol\u003C\u002Fa\u003E and low-density lipoprotein (\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fheart-disease\u002Fldl-cholesterol-the-bad-cholesterol\" crossLinkId=\"59022\" keywordSetId=\"1461\" externalId=\"091e9c5e8028aaf6\" keywordId=\"42789\" chronic_id=\"091e9c5e8028aaf6\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003ELDL\u003C\u002Fa\u003E or \"bad\") cholesterol in people with or without hyperlipidemia.\u003C\u002Fli\u003E \u003Cli\u003EObesity. Taking alpha-lipoic acid by mouth can slightly reduce \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fobesity\u002Fhealthy-weight\" crossLinkId=\"1903515\" keywordSetId=\"8910\" externalId=\"091e9c5e816856bb\" keywordId=\"35915\" chronic_id=\"091e9c5e816856bb\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ebody weight\u003C\u002Fa\u003E in adults who are overweight. \u003C\u002Fli\u003E\u003C\u002Ful\u003E ","PossiblyInEffective":"\u003Cul\u003E \u003Cli\u003ELiver disease in people who drink alcohol. Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fhepatitis\u002Fliver-function-test-lft\" crossLinkId=\"1514148\" keywordSetId=\"32870\" externalId=\"091e9c5e8068dce6\" keywordId=\"72818\" chronic_id=\"091e9c5e8068dce6\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Eliver function\u003C\u002Fa\u003E or reduce \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fdigestive-disorders\u002Fpicture-of-the-liver\" crossLinkId=\"73851\" keywordSetId=\"10464\" externalId=\"091e9c5e80348a30\" keywordId=\"42791\" chronic_id=\"091e9c5e80348a30\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Eliver\u003C\u002Fa\u003E damage in people with alcohol-related liver disease.\u003C\u002Fli\u003E \u003Cli\u003EAltitude sickness. Taking alpha-lipoic acid by mouth along with \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fvitamins-supplements\u002Fingredientmono-1001-vitamin-c-ascorbic-acid.aspx?activeingredientid=1001&activeingredientname=vitamin-c-(ascorbic-acid)\" crossLinkId=\"1884444\" keywordSetId=\"31339\" externalId=\"1001\" keywordId=\"69419\" chronic_id=\"\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Evitamin C\u003C\u002Fa\u003E and \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fvitamins-supplements\u002Fingredientmono-954-vitamin-e.aspx?activeingredientid=954&activeingredientname=vitamin-e\" crossLinkId=\"1884399\" keywordSetId=\"41108\" externalId=\"954\" keywordId=\"93779\" chronic_id=\"\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Evitamin E\u003C\u002Fa\u003E does not seem to prevent altitude sickness.\u003C\u002Fli\u003E \u003Cli\u003E\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fkidney-stones\u002Fpicture-of-the-kidneys\" crossLinkId=\"72677\" keywordSetId=\"26662\" externalId=\"091e9c5e803f72c0\" keywordId=\"60461\" chronic_id=\"091e9c5e803f72c0\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003EKidney\u003C\u002Fa\u003E damage caused by contrast dyes (contrast induced nephropathy). Taking alpha-lipoic acid by mouth with or without standard \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fa-to-z-guides\u002Fdehydration-adults\" crossLinkId=\"900\" keywordSetId=\"1077\" externalId=\"091e9c5e8000b073\" keywordId=\"94660\" chronic_id=\"091e9c5e8000b073\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ehydration\u003C\u002Fa\u003E therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents.\u003C\u002Fli\u003E \u003Cli\u003EDiabetes. Taking alpha-lipoic acid by mouth or by IV does not improve blood sugar levels in people with \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Ftype-2-diabetes\" crossLinkId=\"1582839\" keywordSetId=\"2021\" externalId=\"091e9c5e80010f55\" keywordId=\"8505\" chronic_id=\"091e9c5e80010f55\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Etype 2 diabetes\u003C\u002Fa\u003E. \u003C\u002Fli\u003E \u003Cli\u003E\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Feye-health\u002Fvision-basics\" crossLinkId=\"3407\" keywordSetId=\"1184\" externalId=\"091e9c5e800076b7\" keywordId=\"35136\" chronic_id=\"091e9c5e800076b7\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003EVision\u003C\u002Fa\u003E problems in people with diabetes (\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fdiabetes\u002Fdiabetic-retinopathy\" crossLinkId=\"1582790\" keywordSetId=\"8582\" externalId=\"091e9c5e80007e43\" keywordId=\"33972\" chronic_id=\"091e9c5e80007e43\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ediabetic retinopathy\u003C\u002Fa\u003E). Taking alpha-lipoic acid by mouth daily for 24 months doesn't improve \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Feye-health\u002Fpicture-of-the-eyes\" crossLinkId=\"72347\" keywordSetId=\"26646\" externalId=\"091e9c5e803ffc74\" keywordId=\"60424\" chronic_id=\"091e9c5e803ffc74\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Eeye\u003C\u002Fa\u003E damage from diabetes.\u003C\u002Fli\u003E \u003Cli\u003E\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Falzheimers\u002Ftypes-dementia\" crossLinkId=\"1218\" keywordSetId=\"47107\" externalId=\"091e9c5e80008c55\" keywordId=\"108635\" chronic_id=\"091e9c5e80008c55\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003EDementia\u003C\u002Fa\u003E in people with advanced \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fhiv-aids\u002Funderstanding-aids-hiv-basics\" crossLinkId=\"1565792\" keywordSetId=\"1340\" externalId=\"091e9c5e80008960\" keywordId=\"7583\" chronic_id=\"091e9c5e80008960\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003EHIV\u003C\u002Fa\u003E\u002FAIDS. Taking alpha-lipoic acid by mouth has no effect on thinking problems in people with HIV.\u003C\u002Fli\u003E \u003Cli\u003EHigh levels of fats called triglycerides in the blood (hypertriglyceridemia). Taking alpha-lipoic acid by mouth doesn't seem to reduce \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fcholesterol-management\u002Flowering-triglyceride-levels\" crossLinkId=\"1560504\" keywordSetId=\"2010\" externalId=\"091e9c5e8028e149\" keywordId=\"71913\" chronic_id=\"091e9c5e8028e149\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Etriglyceride levels\u003C\u002Fa\u003E in most people.\u003C\u002Fli\u003E \u003C\u002Ful\u003E There is interest in using alpha-lipoic acid for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful. ","SideEffects":"\u003Cb\u003EWhen taken by mouth\u003C\u002Fb\u003E: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting. \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EWhen applied to the skin\u003C\u002Fb\u003E: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people. \u003Ch4\u003ESpecial Precautions & Warnings:\u003C\u002Fh4\u003E \u003Cb\u003EPregnancy\u003C\u002Fb\u003E: When taken by mouth, alpha-lipoic acid is possibly safe. It's been used safely during pregnancy in doses of up to 600 mg daily for up to 4 weeks. \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EBreast-feeding\u003C\u002Fb\u003E: There isn't enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EChildren\u003C\u002Fb\u003E: Alpha-lipoic acid is possibly safe in children aged 10-17 years when taken by mouth in doses up to 600 mg daily for 3 months. But it is possibly unsafe for children to take large amounts of alpha-lipoic acid by mouth. Seizures, vomiting, and unconsciousness have been reported for children aged 14 months to 16 years who took up to 2400 mg of alpha-lipoic acid as a single dose.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003ESurgery\u003C\u002Fb\u003E: Alpha-lipoic acid can decrease blood sugar levels. Alpha-lipoic acid might interfere with blood sugar control during and after surgery. Stop taking alpha-lipoic acid 2 weeks before elective surgical procedures.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E \u003Cb\u003EExcessive use of alcohol\u002F\u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fwernicke-korsakoff-syndrome-facts\" crossLinkId=\"1907340\" keywordSetId=\"10086\" externalId=\"091e9c5e818dcd96\" keywordId=\"41771\" chronic_id=\"091e9c5e818dcd96\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Ethiamine deficiency\u003C\u002Fa\u003E\u003C\u002Fb\u003E: Alcohol can lower the amount of thiamine (vitamin B1) in the body. Taking alpha-lipoic acid when there is a shortage of thiamine might cause serious health problems. If you drink a lot of alcohol and take alpha-lipoic acid, you should take a thiamine supplement.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E ","PtEdDescription":"Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fmen\u002Fvideo\u002Flamm-supplements-diet\" crossLinkId=\"1600841\" keywordSetId=\"9847\" externalId=\"091e9c5e800ccbab\" keywordId=\"40266\" chronic_id=\"091e9c5e800ccbab\" crossLinkType=\"Video\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Esupplements\u003C\u002Fa\u003E. Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fhepatitis\u002Fliver-and-hepatic-diseases\" crossLinkId=\"1909768\" keywordSetId=\"51561\" externalId=\"091e9c5e81b881fe\" keywordId=\"118047\" chronic_id=\"091e9c5e81b881fe\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Eliver diseases\u003C\u002Fa\u003E.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E People most commonly use alpha-lipoic acid for \u003Ca href=\"http:\u002F\u002Fwww.webmd.com\u002Fbrain\u002Fnerve-pain-and-nerve-damage-symptoms-and-causes\" crossLinkId=\"58569\" keywordSetId=\"10418\" externalId=\"091e9c5e8027ef13\" keywordId=\"42698\" chronic_id=\"091e9c5e8027ef13\" crossLinkType=\"Article\" directive=\"friendlyurl\" object_type=\"wbmd_pb_page\"\u003Enerve pain\u003C\u002Fa\u003E in people with diabetes. 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