Minoryx Advance clinical study

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itemprop="item" title="Clinical Studies" href="/clinical-studies/"><span itemprop="name">Clinical Studies</span></a><meta itemprop="position" content="1"/></span> <i class="fa fa-angle-right" aria-hidden="true"></i></span><span itemprop="itemListElement" itemscope="" itemtype="http://schema.org/ListItem"><a itemprop="item" href="https://www.minoryx.com/clinical-studies/clinical-study-advance/"></a><span><a itemprop="item" href="/clinical-studies/clinical-study-advance/"></a><span class="selected" title="ADVANCE" itemprop="name">ADVANCE</span></span><meta itemprop="position" content="2"/></span> </span> </div> </div> </div> </article> </section></li> </ul> <ul id="panel_pacientes25_1" class="panel_pacientes"> <li data-index="0" id="panel_pacientes_item11_1" class="item col-0 clearfix"><section class="mdl-pacientes"> <div class="m-articles"> <article class="active"> <div class="m-info1"> <div class="m-content"> <div> <div class="m-texto"> <div> <div class="m-title"><div>The ADVANCE Clinical Study for X-ALD</div></div> <div class="m-text"><p style="text-align: justify;">The ADVANCE trial was a pivotal phase 2/3 randomized, double-blind, placebo-controlled, clinical study with an open-label extension still ongoing that was designed to assess the efficacy and safety of leriglitazone in male patients with <span>X-linked Adrenoleukodystrophy (</span>X-ALD).</p></div> </div> </div> <div class="m-image deferbg" data-mobile="/content/imgsxml/panel_pacientes/advance706.jpg" data-tablet="/content/imgsxml/panel_pacientes/advance706.jpg" data-desktop="/content/imgsxml/panel_pacientes/advance706.jpg"><img src="/content/thumbs/582_400-10/content/imgsxml/panel_pacientes/advance706.jpg" class="deferimg" data-mobile="/content/imgsxml/panel_pacientes/advance706.jpg" data-tablet="/content/imgsxml/panel_pacientes/advance706.jpg" data-desktop="/content/imgsxml/panel_pacientes/advance706.jpg" alt="" title="" ></div> </div> </div> </div> <div class="m-infoextra"> <div class="m-info2"> <div class="m-content"> <div class="m-text"><p style="text-align: justify;">The study was divided into two parts. The first part was a two-year double blind placebo-controlled phase with a 2:1 (active:placebo) randomization, aimed to measure multiple efficacy and safety parameters. This was followed by a still active open-label extension where all patients who completed the first part are treated on active.</p> <p style="text-align: justify;">The study was designed with input from both EMA and FDA, as well as EU and US clinical experts in X-ALD and patient advocacy groups.</p> <p style="text-align: justify;">The ADVANCE study recruited 116 patients and results from the double-blind phase showed reduction of cerebral lesion progression and reduction of progression of myelopathy symptoms. The data of this trial was<span> published in The Lancet Neurology: <a href="https://www.sciencedirect.com/science/article/abs/pii/S1474442222004951">Safety and efficacy of leriglitazone for preventing disease progression in men with adrenomyeloneuropathy (ADVANCE): a randomised, double-blind, multi-centre, placebo-controlled phase 2–3 trial - ScienceDirect</a> <span style="color: #00ccff;"></span></span></p> <p>For further information visit:<br /> <a href="https://clinicaltrials.gov/ct2/show/NCT03231878?term=NCT03231878&rank=1" target="_blank" rel="noopener"><span style="color: #00ccff;">https://clinicaltrials.gov/ct2/show/NCT03231878?term=NCT03231878&rank=1</span></a></p></div> </div> </div> <div class="m-info3"> <div class="m-content"> <div> <div class="m-head"><div class="m-title">Hospitals involved in ADVANCE Clinical Study</div> <div class="m-boton2 m-map sta-hoverOFF"><i></i><i></i><i></i><i></i>See map</div> </div> <div class="m-articles"> <article> <div class="m-country">ICM, Groupe Hospitalier Pitié Salpêtrière</div> <div class="m-titulo">Paris</div> <div class="m-contacto">France</div> <footer> </footer> </article> <article> <div class="m-country">Universitat Leipzig Klinik and Poliklinik für Neurologie</div> <div class="m-titulo">Leipzig</div> <div class="m-contacto">Germany</div> <footer> </footer> </article> <article> <div class="m-country">Institute of Genomic Medicine and Rare Disorders</div> <div class="m-titulo">Budapest</div> <div class="m-contacto">Hungary</div> <footer> </footer> </article> <article> <div class="m-country">Instituto Neurologico Carlo Besta</div> <div class="m-titulo">Milano</div> <div class="m-contacto">Italy</div> <footer> </footer> </article> <article> <div class="m-country">Academish Medisch Centrum</div> <div class="m-titulo">Amsterdam</div> <div class="m-contacto">Netherlands</div> <footer> </footer> </article> <article> <div class="m-country">Hospital Universitari Vall d'Hebrón</div> <div class="m-titulo">Barcelona</div> <div class="m-contacto">Spain</div> <footer> </footer> </article> <article> <div class="m-country">National hospital for Neurology and Neurosurgery Charles Dent Metabolic Unit</div> <div class="m-titulo">London</div> <div class="m-contacto">United Kingdom</div> <footer> </footer> </article> <article> <div class="m-country">Massachusetts General Hospital</div> <div class="m-titulo">Boston, Massachusetts</div> <div class="m-contacto">United States</div> <footer> </footer> </article> <article> <div class="m-country">Kennedy Krieger Institute</div> <div class="m-titulo">Baltimore, Maryland</div> <div class="m-contacto">United States</div> <footer> </footer> </article> <article> <div class="m-country">Stanford University Medical Center</div> <div class="m-titulo">Stanford, California</div> <div class="m-contacto">United States</div> <footer> </footer> </article> </div> </div> </div> </div> <div class="m-info4"> <div class="m-content"> <div> <div class="m-head"><div class="m-title">Hospitals involved in ADVANCE Clinical Study</div> <div class="m-boton2 m-list sta-hoverOFF"><i></i><i></i><i></i><i></i>See list</div> </div> <div class="m-mapa"> <img src="/content/imgs/white.png" class="deferimg" data-desktop="/negocio/plantillas/panels/pacientes/mapa.jpg" data-tablet="/negocio/plantillas/panels/pacientes/mapa.jpg" data-mobile="/negocio/plantillas/panels/pacientes/mapa.jpg" alt="Map"> <div class="puntos"> <div class="punto" style="top:30.80380417230561%; left:62.773534719892545%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">ICM, Groupe Hospitalier Pitié Salpêtrière</div> <div class="m-titulo">Paris</div> <div class="m-contacto">France</div> <footer> </footer> </div> </div> <div class="punto" style="top:29.178149606299215%; left:66.27885180411579%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Universitat Leipzig Klinik and Poliklinik für Neurologie</div> <div class="m-titulo">Leipzig</div> <div class="m-contacto">Germany</div> <footer> </footer> </div> </div> <div class="punto" style="top:33.62040842611959%; left:69.895645868864%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Institute of Genomic Medicine and Rare Disorders</div> <div class="m-titulo">Budapest</div> <div class="m-contacto">Hungary</div> <footer> </footer> </div> </div> <div class="punto" style="top:34.722770630843996%; left:65.95005234368413%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Instituto Neurologico Carlo Besta</div> <div class="m-titulo">Milano</div> <div class="m-contacto">Italy</div> <footer> </footer> </div> </div> <div class="punto" style="top:27.888779527559056%; left:63.51075378253306%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Academish Medisch Centrum</div> <div class="m-titulo">Amsterdam</div> <div class="m-contacto">Netherlands</div> <footer> </footer> </div> </div> <div class="punto" style="top:38.18733755997785%; left:62.20679694800069%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Hospital Universitari Vall d'Hebrón</div> <div class="m-titulo">Barcelona</div> <div class="m-contacto">Spain</div> <footer> </footer> </div> </div> <div class="punto" style="top:27.506897283531412%; left:60.95568622696411%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">National hospital for Neurology and Neurosurgery Charles Dent Metabolic Unit</div> <div class="m-titulo">London</div> <div class="m-contacto">United Kingdom</div> <footer> </footer> </div> </div> <div class="punto" style="top:31.40256025659756%; left:34.76937280284415%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Massachusetts General Hospital</div> <div class="m-titulo">Boston, Massachusetts</div> <div class="m-contacto">United States</div> <footer> </footer> </div> </div> <div class="punto" style="top:39.52592023714321%; left:28.4706626864646%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Kennedy Krieger Institute</div> <div class="m-titulo">Baltimore, Maryland</div> <div class="m-contacto">United States</div> <footer> </footer> </div> </div> <div class="punto" style="top:39.104330708661415%; left:9.188586516346005%"> <div class="dot" ></div> <div class="pointdata"> <div class="m-country">Stanford University Medical Center</div> <div class="m-titulo">Stanford, California</div> <div class="m-contacto">United States</div> <footer> </footer> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </section></li> </ul> <ul id="panel_textofoto25_3" class="panel_textofoto"> <li data-index="0" id="panel_textofoto_item12_3" class="item col-0 clearfix"><section class="mdl-textofoto"> <div class="m-articles"> <article> <div class="m-info1"> <div class="m-content"> <div> <div class="m-texto"> <div> <div class="m-title"><div>Contact</div></div> <div class="m-text"><p>Feel free to contact us in case you are interested in any of these clinical studies</p></div> </div> <div> <div class="m-email"> <a href="mailto:info@minoryx.com" title="info@minoryx.com">info@minoryx.com</a> </div> <div class="m-phone"> <a href="tel:+34 93 544 14 66" title="+34 93 544 14 66">+34 93 544 14 66</a> </div> </div> </div> <div class="m-image deferbg" data-mobile="/content/imgsxml/panel_textofoto/contacto264.jpg" data-tablet="/content/imgsxml/panel_textofoto/contacto264.jpg" data-desktop="/content/imgsxml/panel_textofoto/contacto264.jpg"> <img src="/content/imgs/white.png" class="deferimg" data-mobile="/content/imgsxml/panel_textofoto/contacto264.jpg" data-tablet="/content/imgsxml/panel_textofoto/contacto264.jpg" data-desktop="/content/imgsxml/panel_textofoto/contacto264.jpg" alt="" title="" > </div> </div> </div> </div> </article> </div> </section> <script type="text/javascript"> var ruta = "/"; 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Minoryx Advance clinical study