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data-variant-image-grouping-option="Color,Colour,Couleur,Farbe" data-variant-image-grouping-option-index=""> <div class="gallery__inner"> <div class="main-image"><div class="slideshow product-slideshow slideshow--custom-initial" data-slick='{"adaptiveHeight":true,"initialSlide":0}'><div class="slide slide--custom-initial" data-media-id="29795147874472"><a class="show-gallery" href="//admeshop.com/cdn/shop/files/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827.png?v=1702464358"><div id="FeaturedMedia-template--16460963283112__main-29795147874472-wrapper" class="product-media-wrapper" data-media-id="template--16460963283112__main-29795147874472" tabindex="-1"> <div class="product-media product-media--image"> <div class="rimage-outer-wrapper" style="max-width: 1299px"> <div class="rimage-wrapper lazyload--placeholder" style="padding-top:100.0%" ><img class="rimage__image lazyload fade-in " data-src="//admeshop.com/cdn/shop/files/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827_{width}x.png?v=1702464358" data-widths="[180, 220, 300, 360, 460, 540, 720, 900, 1080, 1296, 1512, 1728, 2048]" data-aspectratio="1.0" data-sizes="auto" alt="" > <noscript> <img class="rimage__image" src="//admeshop.com/cdn/shop/files/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827_1024x1024.png?v=1702464358" alt=""> </noscript> </div> </div> </div> </div> </a></div></div> <div class="slideshow-controls"> <div class="slideshow-controls__arrows"></div> </div> <span class="product-label-list"><script id="variant-label-8031101943976-45609200517288" type="text/template"></script><div class="product-label-container"></div></span> </div> <div class="title-row" > <h1 class="title">Efflux transporter substrate screening</h1> </div> <div class="" > <div class="product-description rte cf"><div id="formula-bar-name-box-wrapper" class="name-box-enabled formula-bar-with-name-box-wrapper" data-mce-fragment="1"> <div id="formula-bar" class="formula-bar formulabar-disabled" data-mce-fragment="1"> <div id="t-formula-bar-input-container" data-mce-fragment="1"> <div dir="ltr" data-mce-fragment="1"> <div spellcheck="false" id="t-formula-bar-input" data-mce-fragment="1"> <div class="cell-input disabled-input" role="combobox" dir="ltr" aria-autocomplete="list" tabindex="0" data-mce-fragment="1" data-mce-tabindex="0" contenteditable="false" docs-unhandledkeys=""> <span data-mce-fragment="1">Apparent permeability of the test compound through MDCK-BCRP and/or MDCK-MDR1(Pgp) cell monolayers in both directions is determined.</span><br data-mce-fragment="1"> </div> </div> </div> </div> </div> </div></div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Protocol</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p>Test concentrations: 1</p><p>Time points: 0, 60 min</p><p>Replicates: 2</p><p>Positive controls</p><p>UPLC/MS/MS analysis</p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Deliverables</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p><span class="metafield-multi_line_text_field">Apparent permeability<br /> <br /> Efflux ratios</span></p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Reporting</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p><span class="metafield-multi_line_text_field">Excel report</span></p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item"> <summary class="cc-accordion-item__title">Background</summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p>A family of ATP binding cassette (ABC) transporters is an important group of membrane transporters involved in drug absorption, distribution and elimination. Regulatory authorities recommend investigating the potential roles of ABC superfamily members ABCB1 (MDR1, P-glycoprotein), and ABCG2 (BCRP) for transporter-mediated drug-drug interactions (DDI), by evaluating whether the new drug candidate is a substrate (potential DDI victim) or an inhibitor (potential DDI perpetrator) towards drug transporters. Additionally, evaluation of inhibition towards bile salt export pump (BSEP, ABCB11) is recommended due to safety concerns associated with inhibition of this transporter. A family of solute carriers (SLC) is an important group of membrane transporters involved in drug absorption, distribution and elimination. Regulatory authorities recommend investigating the potential roles of SLC superfamily members OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1 and MATE2 for transporter-mediated drug-drug interactions (DDI), by evaluating whether the new drug candidate is a substrate (potential DDI victim) or an inhibitor (potential DDI perpetrator) towards drug transporters. In addition, it is also worthwhile considering investigation of OCT1, whenever in vitro and in vivo findings suggest its involvement in DDI to be anticipated.</p></div> </div> </details> </div> </div> </div> </div> <div class="detail product-column-right" data-cc-animate data-cc-animate-delay="0.2s"> <div class="product-form" data-ajax-add-to-cart="true" data-product-id="8031101943976" data-enable-history-state="true"> <div class="buy-buttons-row" > <form method="post" action="/cart/add" id="product-form-template--16460963283112__main-8031101943976" accept-charset="UTF-8" class="form product-purchase-form" enctype="multipart/form-data" data-product-id="8031101943976"><input type="hidden" name="form_type" value="product" /><input type="hidden" name="utf8" value="✓" /> <select name="id" class="original-selector hidden" aria-label="Options"> <option value="45609200517288" selected="selected" data-stock="">Default Title</option> </select> <div class="quantity-submit-row input-row "> <div 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Title"],"price":0,"weight":0,"compare_at_price":null,"inventory_management":null,"barcode":"","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/admeshop.com\/cdn\/shop\/files\/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827.png?v=1702464358"],"featured_image":"\/\/admeshop.com\/cdn\/shop\/files\/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827.png?v=1702464358","options":["Title"],"media":[{"alt":null,"id":29795147874472,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1299,"width":1299,"src":"\/\/admeshop.com\/cdn\/shop\/files\/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827.png?v=1702464358"},"aspect_ratio":1.0,"height":1299,"media_type":"image","src":"\/\/admeshop.com\/cdn\/shop\/files\/Permeability_TransportersNEG_c3cb420a-33af-42e1-bad7-b8af5137e827.png?v=1702464358","width":1299}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cdiv id=\"formula-bar-name-box-wrapper\" 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