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<!doctype html> <html data-n-head-ssr lang="en" data-n-head="%7B%22lang%22:%7B%22ssr%22:%22en%22%7D%7D"> <head > <meta data-n-head="ssr" charset="utf-8"><meta data-n-head="ssr" name="viewport" content="width=device-width,initial-scale=1.0,maximum-scale=1.0, user-scalable=0"><meta data-n-head="ssr" http-equiv="Content-Security-Policy" content="default-src * data:; child-src * 'self' blob: http:;img-src * 'self' data: http:; script-src 'self' 'unsafe-inline' 'unsafe-eval' *;style-src 'self' 'unsafe-inline' *"><meta data-n-head="ssr" name="description" content="Guest Editor: Remco de Bree,A Special Issue of Journal of Cancer Metastasis and Treatment,Topic: Lymph Node Metastases in the Neck,Special Issue Introduction:The current Special Issue will highlight the recent key findings in the field of lymph node metastases in the neck and new strategies to improve the therapy for this disease. Topics of interest include, but are not limited to: • Sentinel node biopsy • PET-CT for the detection of occult lymph node metastasis • Radiological assessment of extranodal extension • Prediction models for cervical lymph node metastasis • Radiomics analysis for preoperative prediction of cervical lymph node metastasis • Machine learning algorithms to predict lymph node metastasis • Elective neck dissection • Modern diagnostic work up lymph node metastasis of unknown primary tumor • FDG-PET guided radiotherapy of the neck • Lymphoscintigraphy guided radiotherapy of the neck • Radiotherapy of the contralateral clinically negative neck • Neck dissection of the contralateral clinically negative neck • Lymph node metastasis in salivary gland carcinoma • Lymph node metastasis of non-melanoma skin cancer • Lymph node metastasis of melanoma -Omgo Nieweg Lymph node metastasis of thyroid cancer • Response evaluation after (chemo)radiation for N+ disease "><meta data-n-head="ssr" name="keywords" content=""><meta data-n-head="ssr" name="twitter:title" title="Topic: Lymph Node Metastases in the Neck"><meta data-n-head="ssr" name="twitter:type" content="OAE Publishing Inc."><meta data-n-head="ssr" name="twitter:description" content="Guest Editor: Remco de Bree,A Special Issue of Journal of Cancer Metastasis and Treatment,Topic: Lymph Node Metastases in the Neck,Special Issue Introduction:The current Special Issue will highlight the recent key findings in the field of lymph node metastases in the neck and new strategies to improve the therapy for this disease. Topics of interest include, but are not limited to: • Sentinel node biopsy • PET-CT for the detection of occult lymph node metastasis • Radiological assessment of extranodal extension • Prediction models for cervical lymph node metastasis • Radiomics analysis for preoperative prediction of cervical lymph node metastasis • Machine learning algorithms to predict lymph node metastasis • Elective neck dissection • Modern diagnostic work up lymph node metastasis of unknown primary tumor • FDG-PET guided radiotherapy of the neck • Lymphoscintigraphy guided radiotherapy of the neck • Radiotherapy of the contralateral clinically negative neck • Neck dissection of the contralateral clinically negative neck • Lymph node metastasis in salivary gland carcinoma • Lymph node metastasis of non-melanoma skin cancer • Lymph node metastasis of melanoma -Omgo Nieweg Lymph node metastasis of thyroid cancer • Response evaluation after (chemo)radiation for N+ disease "><meta data-n-head="ssr" 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Metastases in the Neck</span></span><span role="presentation" class="el-breadcrumb__separator"></span></span></div></div> <div class="wrapper" data-v-689343a6><div class="top_line2" data-v-689343a6></div> <h2 class="oae_header_tit" data-v-689343a6>Special Issue</h2> <div class="line_list" data-v-689343a6></div> <div class="art_content" data-v-689343a6><div class="art_info" data-v-689343a6><div class="volume_top_con" data-v-689343a6><div class="top_left" data-v-689343a6><div class="imgBig" data-v-750ffa2e data-v-689343a6><div class="left" data-v-750ffa2e><img src="https://i.oaes.cc/public/issue_special/526/62_jcmt_sp526.jpg" alt class="leftImg" data-v-750ffa2e> <div class="top" style="transform:;display:none;" data-v-750ffa2e></div> <div class="maskTop" data-v-750ffa2e></div></div> <div class="right" style="display:none;" data-v-750ffa2e><img src="https://i.oaes.cc/public/issue_special/526/62_jcmt_sp526.jpg" alt class="rightImg" data-v-750ffa2e></div></div></div> <div class="top_right" data-v-689343a6><h1 id="ar_num" data-v-689343a6>Topic: Lymph Node Metastases in the Neck</h1> <div class="iss_download" data-v-689343a6><a href="https://f.oaes.cc/read_online/special_issue/jcmt/526/526.html" target="_blank" data-v-689343a6><button type="button" class="el-button el-button--default el-button--mini" data-v-689343a6><span><i class="icon-view icon_right4" data-v-689343a6></i> Read Online</span></button></a> <a href="https://f.oaes.cc/special/526.zip" target="_blank" data-v-689343a6><button type="button" class="el-button el-button--default el-button--mini" data-v-689343a6><span><i class="iconfont icon-xiazai1" data-v-689343a6></i> Download All Articles</span></button></a> </div> <div class="ar_p" data-v-689343a6><p data-v-689343a6> A Special Issue of <a href="/" class="nuxt-link-active" data-v-689343a6><i data-v-689343a6>Journal of Cancer Metastasis and Treatment</i></a></p> <p data-v-689343a6><span class="T_Print" data-v-689343a6>ISSN 2454-2857 (Online) 2394-4722 (Print)</span></p> <p data-v-689343a6> Submission deadline: <span class="T_Deadline" data-v-689343a6>30 Jun 2022</span></p></div></div></div> <div class="t_public" data-v-689343a6><h2 class="t_title" data-v-689343a6>Guest Editor(s)</h2> <div class="auther_list" data-v-689343a6><div class="auther_item" data-v-689343a6><div class="auther_tit" data-v-689343a6>Prof. Remco de Bree</div> <div class="auther_p" data-v-689343a6>Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.</div> <div class="auther_btn" data-v-689343a6><span data-v-689343a6><a href="https://www.umcutrecht.nl/nl/zorgverleners/bree-r-de" target="_blank" data-v-689343a6><button type="button" class="el-button el-button--text" data-v-689343a6><span>Website</span></button></a> <span class="btn_line" style="display: none;" data-v-689343a6></span></span> <span data-v-689343a6><span class="btn_line" data-v-689343a6></span> <a href="mailto:R.deBree@umcutrecht.nl" data-v-689343a6><button type="button" class="el-button el-button--text" data-v-689343a6><span><i class="iconfont icon-email" data-v-689343a6></i> E-mail</span></button></a></span></div></div></div>    <h2 class="t_title" data-v-689343a6>Special Issue Introduction</h2> <div id="seo_dis" data-v-689343a6>The current Special Issue will highlight the recent key findings in the field of lymph node metastases in the neck and new strategies to improve the therapy for this disease.<br/><br/> Topics of interest include, but are not limited to: <br/><br/> • Sentinel node biopsy<br/> • PET-CT for the detection of occult lymph node metastasis<br/> • Radiological assessment of extranodal extension<br/> • Prediction models for cervical lymph node metastasis<br/> • Radiomics analysis for preoperative prediction of cervical lymph node metastasis<br/> • Machine learning algorithms to predict lymph node metastasis<br/> • Elective neck dissection<br/> • Modern diagnostic work up lymph node metastasis of unknown primary tumor<br/> • FDG-PET guided radiotherapy of the neck<br/> • Lymphoscintigraphy guided radiotherapy of the neck<br/> • Radiotherapy of the contralateral clinically negative neck <br/> • Neck dissection of the contralateral clinically negative neck<br/> • Lymph node metastasis in salivary gland carcinoma<br/> • Lymph node metastasis of non-melanoma skin cancer<br/> • Lymph node metastasis of melanoma -Omgo Nieweg Lymph node metastasis of thyroid cancer<br/> • Response evaluation after (chemo)radiation for N+ disease <br/><br/></div>  <div id="seo_tit" data-v-689343a6></div> <h2 class="t_title" data-v-689343a6>Submission Deadline</h2> <div data-v-689343a6>30 Jun 2022</div> <h2 class="t_title" data-v-689343a6>Submission Information</h2> <div class="last_t" data-v-689343a6><p data-v-689343a6>For Author Instructions, please refer to <a href="https://www.oaepublish.com/jcmt/author_instructions" target="_self" _href="https://www.oaepublish.com/jcmt/author_instructions" textvalue="https://www.oaepublish.com/jcmt/author_instructions">https://www.oaepublish.com/jcmt/author_instructions</a><br/> For Online Submission, please login at <a href="https://oaemesas.com/login?JournalId=jcmt&SpecialIssueId=526" target="_blank">https://oaemesas.com/login?JournalId=jcmt&SpecialIssueId=526</a> <br/> Submission Deadline: 30 Jun 2022<br/>Contacts: Ivory Ma, Assistant Editor, <a href="mailto:ivory@jcmtjournal.com">ivory@jcmtjournal.com</a></p></div> </div></div></div> <div class="pubA" data-v-689343a6><h2 class="oae_header" data-v-689343a6>Published Articles</h2> <div class="line_btn" data-v-689343a6></div> <div class="data_list" data-v-689343a6><div class="article_item" data-v-013e4f74 data-v-689343a6><div data-v-013e4f74> <div class="article-abs w100" data-v-013e4f74><a href="/articles/2394-4722.2022.101" data-v-013e4f74><div class="list_title phone-abs" data-v-013e4f74>Current controversies in the management of neck node metastasis in differentiated thyroid cancer</div></a> <div class="article-block" data-v-013e4f74><span class="block-f17452" data-v-013e4f74>Open Access</span> <span class="btn_line" data-v-013e4f74></span> <span class="block-999" data-v-013e4f74>Review</span> <span class="btn_line" data-v-013e4f74></span> <span data-v-013e4f74>31 May 2023</span></div> <div class="doi_box" data-v-013e4f74> DOI: <a href="/articles/2394-4722.2022.101" data-v-013e4f74>10.20517/2394-4722.2022.101</a></div> <div class="article-author" data-v-013e4f74>Ashok R. 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{layout:"oaelayoutc",data:[{IssData:{setting_value:bs,deadline:1656547200,image:"https:\u002F\u002Fi.oaes.cc\u002Fpublic\u002Fissue_special\u002F526\u002F62_jcmt_sp526.jpg",section_id:x,email:"ivory@jcmtjournal.com",introduction:"The current Special Issue will highlight the recent key findings in the field of lymph node metastases in the neck and new strategies to improve the therapy for this disease.\u003Cbr\u002F\u003E\u003Cbr\u002F\u003E Topics of interest include, but are not limited to: \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E • Sentinel node biopsy\u003Cbr\u002F\u003E • PET-CT for the detection of occult lymph node metastasis\u003Cbr\u002F\u003E • Radiological assessment of extranodal extension\u003Cbr\u002F\u003E • Prediction models for cervical lymph node metastasis\u003Cbr\u002F\u003E • Radiomics analysis for preoperative prediction of cervical lymph node metastasis\u003Cbr\u002F\u003E • Machine learning algorithms to predict lymph node metastasis\u003Cbr\u002F\u003E • Elective neck dissection\u003Cbr\u002F\u003E • Modern diagnostic work up lymph node metastasis of unknown primary tumor\u003Cbr\u002F\u003E • FDG-PET guided radiotherapy of the neck\u003Cbr\u002F\u003E • Lymphoscintigraphy guided radiotherapy of the neck\u003Cbr\u002F\u003E • Radiotherapy of the contralateral clinically negative neck \u003Cbr\u002F\u003E • Neck dissection of the contralateral clinically negative neck\u003Cbr\u002F\u003E • Lymph node metastasis in salivary gland carcinoma\u003Cbr\u002F\u003E • Lymph node metastasis of non-melanoma skin cancer\u003Cbr\u002F\u003E • Lymph node metastasis of melanoma -Omgo Nieweg Lymph node metastasis of thyroid cancer\u003Cbr\u002F\u003E • Response evaluation after (chemo)radiation for N+ disease \u003Cbr\u002F\u003E\u003Cbr\u002F\u003E",keywords:a,sub_link:"https:\u002F\u002Foaemesas.com\u002Flogin?JournalId=jcmt&SpecialIssueId=526",downurl:"https:\u002F\u002Ff.oaes.cc\u002Fspecial\u002F526.zip",information:"For Author Instructions, please refer to \u003Ca href=\"https:\u002F\u002Fwww.oaepublish.com\u002Fjcmt\u002Fauthor_instructions\" target=\"_self\" _href=\"https:\u002F\u002Fwww.oaepublish.com\u002Fjcmt\u002Fauthor_instructions\" textvalue=\"https:\u002F\u002Fwww.oaepublish.com\u002Fjcmt\u002Fauthor_instructions\"\u003Ehttps:\u002F\u002Fwww.oaepublish.com\u002Fjcmt\u002Fauthor_instructions\u003C\u002Fa\u003E\u003Cbr\u002F\u003E For Online Submission, please login at \u003Ca href=\"https:\u002F\u002Foaemesas.com\u002Flogin?JournalId=jcmt&SpecialIssueId=526\" target=\"_blank\"\u003Ehttps:\u002F\u002Foaemesas.com\u002Flogin?JournalId=jcmt&SpecialIssueId=526\u003C\u002Fa\u003E \u003Cbr\u002F\u003E Submission Deadline: 30 Jun 2022\u003Cbr\u002F\u003EContacts: Ivory Ma, Assistant Editor, \u003Ca href=\"mailto:ivory@jcmtjournal.com\"\u003Eivory@jcmtjournal.com\u003C\u002Fa\u003E",issue_flyer:a,issn:a$,auther:[{username:"Prof. Remco de Bree",affiliation:"Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.",website:"https:\u002F\u002Fwww.umcutrecht.nl\u002Fnl\u002Fzorgverleners\u002Fbree-r-de",email:"R.deBree@umcutrecht.nl"}],autherAssist:[],autherGuest:[],readurl:"https:\u002F\u002Ff.oaes.cc\u002Fread_online\u002Fspecial_issue\u002Fjcmt\u002F526\u002F526.html",planned:a,article:[{date_published:1685548800,section:ar,section_id:B,title:"Current controversies in the management of neck node metastasis in differentiated thyroid cancer",doi:"10.20517\u002F2394-4722.2022.101",abstract:"\u003Cp\u003EThe incidence of nodal metastasis is quite common in well-differentiated thyroid cancer. However, its clinical significance is generally quite minimal. The adverse pathological features need to be recognized. The debate continues over prophylactic central compartment dissection. However, it needs to be re-evaluated in terms of complications of elective procedure. The extent of lateral neck dissection is standardized from level II through level V. Recurrent nodal disease is more likely to be persistent nodal disease. Appropriate preoperative imaging is very crucial. Surgery for recurrent disease needs to be considered based on nodal prognostic factors and location of the disease. The approach of using active surveillance and continuous monitoring is reasonable, especially for recurrence below 1 cm.\u003C\u002Fp\u003E",pdfurl:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F1185cab5-4320-4b68-94f6-06fcd307ed9d\u002F5776.pdf",elocation_id:C,fpage:b,article_id:5776,viewed:267,downloaded:ba,video_url:b,volume:D,year:bt,tag:bu,image:as,authors:bv,video_img:a,journal_path:p,lpage:b,author:bv,specialissue:{id:x,name:E},specialinfo:a,url_doi:"2394-4722.2022.101"},{date_published:1684771200,section:"Narrative Review",section_id:1516,title:"Lymph nodes of the perimandibular area: from anatomical classification to pathological role in cancer of the oral cavity, oropharynx and skin",doi:"10.20517\u002F2394-4722.2022.98",abstract:"\u003Cp\u003ELymph node status of the neck is the most important prognostic factor in head and neck cancer. Neck dissection, which consists of the systematic excision of the neck nodes, represents the gold standard of surgical treatment in clinically positive necks. In cases in which metastases to lymph nodes of the neck are not detectable, the decision to perform an elective neck dissection depends on the stage and the site of the primary tumor. This narrative review focuses on the anatomical description and oncological role of a group of lymph nodes of the neck that historically has not been well defined. Over the years, several authors have described the groups of lymph nodes that lie where the facial vein crosses the mandible, but to date, no unique definition or a clear view of their oncological role has been proposed. Recently, the term “perimarginal nodes” was coined to refer to this group of lymph nodes, and emphasis was placed on the risk of leaving them undissected during neck dissection. This paper aims to provide a surgical-anatomical classification of these lymph nodes and describe their oncological role on the basis of a review of the relevant literature.\u003C\u002Fp\u003E",pdfurl:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F388bc247-7448-4c57-ba9d-e7e65a4e2574\u002F5741.pdf",elocation_id:y,fpage:b,article_id:5741,viewed:315,downloaded:297,video_url:b,volume:D,year:bt,tag:bb,image:"https:\u002F\u002Foaepublishstorage.blob.core.windows.net\u002F388bc247-7448-4c57-ba9d-e7e65a4e2574\u002F5741-coverimg.jpg",authors:bw,video_img:a,journal_path:p,lpage:b,author:bw,specialissue:{id:x,name:E},specialinfo:a,image_list:"https:\u002F\u002Fimage.oaes.cc\u002F388bc247-7448-4c57-ba9d-e7e65a4e2574\u002F5741-coverimg.jpg",url_doi:"2394-4722.2022.98"},{date_published:1671724800,section:"Original Article",section_id:bc,title:"Diagnostic accuracy of MRI and PET\u002FCT for neck staging prior to salvage total laryngectomy",doi:"10.20517\u002F2394-4722.2022.19",abstract:"\u003Cp\u003E\u003Cb\u003EAim:\u003C\u002Fb\u003E Lymph node (LN) metastases are associated with poor outcomes in patients with recurrent larynx squamous cell carcinoma (LSCC). Neck dissection (ND) is therefore commonly performed along with salvage total laryngectomy (STL). Here, we assess the rate of occult LN metastases and the diagnostic value of MRI and PET\u002FCT for detecting them in recurrent LSCC.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EMethods:\u003C\u002Fb\u003E This retrospective study included patients with recurrent LSCC after primary (chemo)radiotherapy [(C)RT] who were re-staged by MRI and\u002For PET\u002FCT and treated with STL and ND between 2004 and 2019. The histopathology of ND samples was used as the reference standard.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EResults:\u003C\u002Fb\u003E Forty-one patients were included. The prevalence of occult metastases in MRI-negative and \u003CInlineParagraph\u003EPET\u002FCT-negative\u003C\u002FInlineParagraph\u003E neck nodes was between 3.2% and 6.1%. Negative predictive values of neck node re-staging were 93.9% for MRI, 96.8% for PET\u002FCT, and 96.2% for MRI and PET\u002FCT combined.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EConclusion:\u003C\u002Fb\u003E Both MRI and PET\u002FCT afforded good negative predictive values for nodal staging in patients with recurrent LSCC after (C)RT prior to STL. In selected patients, these radiological modalities, particularly PET\u002FCT, could help to avoid unnecessary surgery to the neck and its associated morbidity.\u003C\u002Fp\u003E",pdfurl:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002Fcfc68c19-1bfb-4331-a7e9-1840af9e0875\u002F5340.pdf",elocation_id:48,fpage:b,article_id:5340,viewed:656,downloaded:676,video_url:b,volume:F,year:bx,tag:bd,image:"https:\u002F\u002Foaepublishstorage.blob.core.windows.net\u002Fcfc68c19-1bfb-4331-a7e9-1840af9e0875\u002F5340-coverimg.jpg",authors:by,video_img:a,journal_path:p,lpage:b,author:by,specialissue:{id:x,name:E},specialinfo:a,image_list:"https:\u002F\u002Fimage.oaes.cc\u002Fcfc68c19-1bfb-4331-a7e9-1840af9e0875\u002F5340-coverimg.jpg",url_doi:"2394-4722.2022.19"},{date_published:1653580800,section:ar,section_id:B,title:"Lymph node metastasis from non-melanoma skin cancer",doi:"10.20517\u002F2394-4722.2022.28",abstract:"\u003Cp\u003EThe management of non-melanoma skin cancers metastatic to the neck is challenging due to variability in biological behavior and patterns of regional lymphatic spread. Metastatic non-melanoma skin cancers to the parotid and neck often behave aggressively, with a high incidence of local recurrence after treatment and reduced five-year survival outcomes. Patterns of lymphatic spread are different from those seen in mucosal squamous cell carcinoma, with higher prevalence of disease in the parotid and superficial lymphatics. These factors require that treatment is individualized to achieve optimal outcomes. Traditionally, the management of non-melanoma skin cancers metastatic to lymph nodes has involved surgical excision followed by adjuvant radiation therapy. However, novel systemic therapies are showing promising results and their role in the management of these cancers is evolving. \u003C\u002Fp\u003E",pdfurl:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F021453e4-4ccd-4bc0-949c-7234c1a020fc\u002F4889.pdf",elocation_id:C,fpage:b,article_id:4889,viewed:2100,downloaded:686,video_url:b,volume:F,year:bx,tag:bu,image:"https:\u002F\u002Foaepublishstorage.blob.core.windows.net\u002F021453e4-4ccd-4bc0-949c-7234c1a020fc\u002F4889-coverimg.jpg",authors:bz,video_img:a,journal_path:p,lpage:b,author:bz,specialissue:{id:x,name:E},specialinfo:a,image_list:"https:\u002F\u002Fimage.oaes.cc\u002F021453e4-4ccd-4bc0-949c-7234c1a020fc\u002F4889-coverimg.jpg",url_doi:"2394-4722.2022.28"},{date_published:1631203200,section:ar,section_id:B,title:"Radiological assessment of extranodal extension in patients with head and neck squamous cell carcinoma",doi:"10.20517\u002F2394-4722.2021.112",abstract:"\u003Cp\u003EThe prognosis of patients with head and neck squamous cell cancer (HNSCC) decreases with the presence of extranodal extension (ENE) in lymph node metastases. Therefore, ENE was introduced in the 8th Edition TNM Classification (TNM8) for Head and Neck Cancer as a staging variable in all HPV-negative HNSCC. Patients with ENE may benefit from adjuvant or even primary chemotherapy and\u002For radiotherapy. There is a clear discrepancy between the definition of clinical ENE and pathological ENE. In TNM8, the radiological evaluation of ENE only plays a supportive role. Since not all patients with advanced disease will undergo a neck dissection, histologic proof of ENE will not always be available. In these cases, it would be of great help to be able to accurately determine ENE with radiological imaging. In this review, an update is given of the ability of radiological imaging to identify and grade ENE.\u003C\u002Fp\u003E",pdfurl:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F859f6cfc-16be-4f6e-b3e7-847f2f934a70\u002F4296.pdf",elocation_id:be,fpage:b,article_id:4296,viewed:2180,downloaded:911,video_url:b,volume:t,year:bA,tag:"56",image:"https:\u002F\u002Foaepublishstorage.blob.core.windows.net\u002F859f6cfc-16be-4f6e-b3e7-847f2f934a70\u002F4296-coverimg.jpg",authors:bB,video_img:a,journal_path:p,lpage:b,author:bB,specialissue:{id:x,name:E},specialinfo:a,image_list:"https:\u002F\u002Fimage.oaes.cc\u002F859f6cfc-16be-4f6e-b3e7-847f2f934a70\u002F4296-coverimg.jpg",url_doi:"2394-4722.2021.112"},{date_published:1620403200,section:ar,section_id:B,title:"\u003Csup\u003E18\u003C\u002Fsup\u003EF-FDG-PET\u002FCT-guided radiotherapy of cervical lymph nodes in head and neck squamous cell carcinoma",doi:"10.20517\u002F2394-4722.2021.55",abstract:"\u003Cp\u003EThe use of positron emission tomography with fluor-18-fluorodeoxyglucose (FDG-PET) in clinical practice for patients with head and neck squamous cell carcinoma (HNSCC) has expanded rapidly, with implications for diagnostic staging, radiotherapy planning, adaptive radiotherapy, and post-therapy evaluation. The implementation of FDG-PET\u002FCT in radiation treatment planning not only has consequences for target volume definition and dose prescription but is also associated with an increased overall survival in patients with HNSCC. FDG-PET\u002FCT-guided gradient dose prescription provides a window of opportunity for treatment de-intensification of the neck in order to decrease treatment-related toxicity without compromising oncological outcome. Further, interim FDG-PET\u002FCT during radiotherapy can be useful to assess metabolic tumor response and enables opportunities for adaptive treatment strategies. The goals are to increase treatment effectivity in poor responders and reduce unnecessary toxicity in patients with good early tumor response. Further prospective trials investigating adaptive radiotherapy based on interim PET-evaluation are needed, especially regarding human papilloma virus-negative HNSCC and patients treated with primary radiotherapy.\u003C\u002Fp\u003E",pdfurl:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F6b1cefe3-d407-4ce9-9172-a5425838efef\u002F4024.pdf",elocation_id:O,fpage:b,article_id:4024,viewed:1330,downloaded:584,video_url:b,volume:t,year:bA,tag:bf,image:"https:\u002F\u002Foaepublishstorage.blob.core.windows.net\u002F6b1cefe3-d407-4ce9-9172-a5425838efef\u002F4024-coverimg.jpg",authors:bC,video_img:a,journal_path:p,lpage:b,author:bC,specialissue:{id:x,name:E},specialinfo:a,image_list:"https:\u002F\u002Fimage.oaes.cc\u002F6b1cefe3-d407-4ce9-9172-a5425838efef\u002F4024-coverimg.jpg",url_doi:"2394-4722.2021.55"}]},metaData:{title:bs,keywords:a,description:"Guest Editor: Remco de Bree,A Special Issue of Journal of Cancer Metastasis and Treatment,Topic: Lymph Node Metastases in the Neck,Special Issue Introduction:The current Special Issue will highlight the recent key findings in the field of lymph node metastases in the neck and new strategies to improve the therapy for this disease. Topics of interest include, but are not limited to: • Sentinel node biopsy • PET-CT for the detection of occult lymph node metastasis • Radiological assessment of extranodal extension • Prediction models for cervical lymph node metastasis • Radiomics analysis for preoperative prediction of cervical lymph node metastasis • Machine learning algorithms to predict lymph node metastasis • Elective neck dissection • Modern diagnostic work up lymph node metastasis of unknown primary tumor • FDG-PET guided radiotherapy of the neck • Lymphoscintigraphy guided radiotherapy of the neck • Radiotherapy of the contralateral clinically negative neck • Neck dissection of the contralateral clinically negative neck • Lymph node metastasis in salivary gland carcinoma • Lymph node metastasis of non-melanoma skin cancer • Lymph node metastasis of melanoma -Omgo Nieweg Lymph node metastasis of thyroid cancer • Response evaluation after (chemo)radiation for N+ disease 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Martin-Moreno","rgb(67,176,42)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fohir.jpg",105,"ohir","#c45284","ISSN 2349-6150 (Online)\u003Cbr\u003EISSN 2347-9264 (Print)","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231110\u002F8d72c3f669d5490ea3b9abc424d66cb6.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fpar","Wen-Guo Cui","520","rgb(196,82,132)","ESCI, Scopus, Dimensions, CNKI, Lens, Wanfang","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fpar.jpg","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240607\u002F9bbbcad710cf457e85d63b1811faefb1.png","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101111784","https:\u002F\u002Fclarivate.com\u002Fproducts\u002Fscientific-and-academic-research\u002Fresearch-discovery-and-workflow-solutions\u002Fwebofscience-platform\u002Fweb-of-science-core-collection\u002Femerging-sources-citation-index\u002F","par",619,"#d62598","ISSN 2771-2893 (Online)","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231121\u002F6ee75e8ab583446b90c97865c2c68464.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Frdodj","Daniel Scherman","28","Dimensions, Lens","rgb(214,37,152)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Frdodj.jpg",106,"rdodj",77,"#1f4e79","ISSN 2769-5441 (Online)","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231110\u002F98e2ed5023ee466c8890d749bfd97597.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fss","YongAn Huang","58","ESCI, Scopus, CAS, Lens, Dimensions, CNKI","rgb(31,78,121)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fss.jpg",107,"https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240606\u002Fcfa200290630438c8e3a3cae1536af37.png","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101178114","ss",116,54,"#a96318","https:\u002F\u002Fi.oaes.cc\u002Fimages_2018\u002Foae\u002Fcover_sh.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fsh","Manoj Shukla","rgb(169,99,24)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fsh.jpg",108,"sh","#4475e1","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231218\u002F79ccda0bc909441587a0b70e0a8ef1cc.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fsmpo","Madjid Tavana","rgb(68,117,225)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fsmpo.jpg",109,"smpo","#53be9b","ISSN 2573-0002 (Online)","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231218\u002F54ba11ec5c57448a84169c318bb94fd4.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fsds","Nikolaos G. Nikitakis","40","rgb(62,163,130)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fsds.jpg",110,"sds","#0038a0","ISSN 2768-5993 (Online)","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231113\u002F695c0f0de82c43f189957ff572f0798c.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fjca","89","rgb(0,56,160)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fjca.png","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240611\u002Fd7d617bceee246428da2ed07a84efd5e.png","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101176723","https:\u002F\u002Fwww.oaepublish.com\u002Fnews\u002Fjca.838","jca",129,36,"#db6868","ISSN 2574-1209 (Online)","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231110\u002Fe64051237c8a454085bb02abfdc6dd12.jpg","https:\u002F\u002Fwww.oaepublish.com\u002Fvp","290","CAS, Scopus, CNKI, Dimensions, Lens","rgb(219,104,104)","https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fvp.jpg","https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240606\u002Fa5cb40102c2d4ec4b1a362fe1f27d324.jpg","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101064905","vp",351,"5555","\u002Fjcmt\u002Fcontact_us","For Authors","https:\u002F\u002Ftwitter.com\u002FOAE_JCMT","\u002F"));</script><script src="https://g.oaes.cc/oae/nuxt/b06ddfb.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/0b0ded9.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/17e402d.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/0a3b980.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/3e8004d.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/b19d7ea.js" defer></script> </body> </html> <div id="noIe" style="display: none;"> <style> #noIe { background: rgba(99, 125, 255, 1); width: 100%; height: 100vh; position: fixed; top: 0; left: 0; z-index: 999999; } #noIe .container { 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100px; } #noIe .logo { height: 24px; } @media screen and (max-width: 820px) { #noIe .container { width: 432px; left: 50%; margin-left: -216px; margin-top: 48px; position: relative; top: 0; } #noIe .container ul { width: 290px; height: 352px; margin-left: -30px; margin-top: 40px; } #noIe .container li { margin-left: 30px; margin-top: 24px; } #noIe .logo-container { padding-top: 121px; padding-bottom: 20px; } } </style> <div class="container"> <p class="title">The current browser is not compatible</p> <p class="title2">The following browsers are recommended for the best use experience</p> <ul> <li> <a href="https://www.google.cn/chrome/" target="_blank"> <img src="https://gw.alicdn.com/imgextra/i2/O1CN01Nn0IoE1cmXZ6gFiM3_!!6000000003643-2-tps-230-230.png" /> <p>Chrome</p> </a> </li> <li> <a href="http://www.firefox.com.cn/" target="_blank"> <img src="https://gw.alicdn.com/imgextra/i3/O1CN01P8aqdX1HdHczGialK_!!6000000000780-2-tps-230-230.png" /> <p>Firefox</p> </a> </li> <li> <a 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" 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