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<div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Leydig cell tumour</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">Testicular interstitial cell tumour</td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Histopathology_of_leydig_cell_tumor_of_the_ovary,_high_mag,_annotated.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Histopathology_of_leydig_cell_tumor_of_the_ovary%2C_high_mag%2C_annotated.png/220px-Histopathology_of_leydig_cell_tumor_of_the_ovary%2C_high_mag%2C_annotated.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Histopathology_of_leydig_cell_tumor_of_the_ovary%2C_high_mag%2C_annotated.png/330px-Histopathology_of_leydig_cell_tumor_of_the_ovary%2C_high_mag%2C_annotated.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Histopathology_of_leydig_cell_tumor_of_the_ovary%2C_high_mag%2C_annotated.png/440px-Histopathology_of_leydig_cell_tumor_of_the_ovary%2C_high_mag%2C_annotated.png 2x" data-file-width="2048" data-file-height="1532" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data">Histopathology of a Leydig cell tumor, high magnification, <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>, showing typical features.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Oncology" title="Oncology">Oncology</a>, <a href="/wiki/Endocrinology" title="Endocrinology">endocrinology</a> <span class="penicon autoconfirmed-show"><span class="mw-valign-text-top" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4000420?uselang=en#P1995" title="Edit this on Wikidata"><img alt="Edit this on Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></td></tr></tbody></table> <p><b>Leydig cell tumour</b>, also <b>Leydig cell tumor</b> (US spelling), <b>(testicular) interstitial cell tumour</b> and <b>(testicular) interstitial cell tumor</b> (US spelling), is a member of the <a href="/wiki/Sex_cord-stromal_tumour" class="mw-redirect" title="Sex cord-stromal tumour">sex cord-stromal tumour</a> group<sup id="cite_ref-pmid18382911_2-0" class="reference"><a href="#cite_note-pmid18382911-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> of <a href="/wiki/Ovarian_cancer" title="Ovarian cancer">ovarian</a> and <a href="/wiki/Testicular_cancer" title="Testicular cancer">testicular cancers</a>. It arises from <a href="/wiki/Leydig_cell" title="Leydig cell">Leydig cells</a>. While the tumour can occur at any age, it occurs most often in young adults. </p><p>A <a href="/wiki/Sertoli%E2%80%93Leydig_cell_tumour" title="Sertoli–Leydig cell tumour">Sertoli–Leydig cell tumour</a> is a combination of a Leydig cell tumour and a <a href="/wiki/Sertoli_cell_tumour" title="Sertoli cell tumour">Sertoli cell tumour</a> from <a href="/wiki/Sertoli_cell" title="Sertoli cell">Sertoli cells</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Presentation">Presentation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=1" title="Edit section: Presentation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The majority of Leydig cell tumors are found in males, usually at 5–10 years of age or in middle adulthood (30–60 years). Children typically present with <a href="/wiki/Precocious_puberty" title="Precocious puberty">precocious puberty</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (May 2021)">citation needed</span></a></i>]</sup> </p><p>Due to excess <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> secreted by the tumour, one-third of female patients present with a recent history of progressive <a href="/wiki/Masculinization" class="mw-redirect" title="Masculinization">masculinization</a>. Masculinization is preceded by <a href="/wiki/Anovulation" title="Anovulation">anovulation</a>, <a href="/wiki/Oligomenorrhea" title="Oligomenorrhea">oligomenorrhea</a>, <a href="/wiki/Amenorrhea" title="Amenorrhea">amenorrhea</a> and <i><a href="/wiki/Defeminization" title="Defeminization">defeminization</a></i>. Additional signs include <a href="/wiki/Acne_vulgaris" class="mw-redirect" title="Acne vulgaris">acne</a> and <a href="/wiki/Hirsutism" title="Hirsutism">hirsutism</a>, voice deepening, <a href="/wiki/Clitoromegaly" title="Clitoromegaly">clitoromegaly</a>, temporal hair recession, and an increase in musculature. Serum testosterone level is high.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (January 2017)">citation needed</span></a></i>]</sup> </p><p>In men, testicular swelling is the most common presenting feature. Other symptoms depend on age and the type of tumour. If it is secreting <a href="/wiki/Androgen" title="Androgen">androgens</a> the tumour is usually asymptomatic, but can cause <a href="/wiki/Precocious_puberty" title="Precocious puberty">precocious puberty</a> in pre-pubertal boys. If the tumour secretes <a href="/wiki/Estrogen" title="Estrogen">oestrogens</a> it can cause feminisation in young boys. In adults, this causes a number of problems including <a href="/wiki/Gynecomastia" title="Gynecomastia">gynaecomastia</a>, erectile dysfunction, infertility, feminine hair distribution, gonadogenital atrophy, and a loss of libido.<sup id="cite_ref-emedicine.medscape.com_3-0" class="reference"><a href="#cite_note-emedicine.medscape.com-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Cause">Cause</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=2" title="Edit section: Cause"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Animal studies a suggest possible link with C8 (C<sub>8</sub>HF<sub>15</sub>O<sub>2</sub>, <a href="/wiki/Perfluorooctanoic_acid" title="Perfluorooctanoic acid">perfluorooctanoic acid</a>). <sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=3" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Presence of an ovarian tumour plus hormonal disturbances suggests a Leydig cell tumour, <a href="/wiki/Granulosa_cell_tumour" title="Granulosa cell tumour">granulosa cell tumour</a> or <a href="/wiki/Thecoma" title="Thecoma">thecoma</a>. However, hormonal disturbances, in Leydig tumours, is present in only 2/3 of cases. Testicular Leydig cell tumours can be detected sonographically, ultrasound examinations may be ordered in the event of a palpable scrotal lump, however incidental identification of these lesions is also possible.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Leydig_cell_tumour1.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Leydig_cell_tumour1.jpg/220px-Leydig_cell_tumour1.jpg" decoding="async" width="220" height="159" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Leydig_cell_tumour1.jpg/330px-Leydig_cell_tumour1.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Leydig_cell_tumour1.jpg/440px-Leydig_cell_tumour1.jpg 2x" data-file-width="2532" data-file-height="1828" /></a><figcaption>Low magnification <a href="/wiki/Micrograph" title="Micrograph">micrograph</a> of a <b>Leydig cell tumour</b>. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>.</figcaption></figure> <p>A conclusive diagnosis is made via <a href="/wiki/Histology" title="Histology">histology</a>, as part of a pathology report made during or after surgery. <a href="/wiki/Reinke_crystals" title="Reinke crystals">Reinke crystals</a> are classically found in these tumours and help confirm the diagnosis, although they are seen in less than half of all Leydig cell tumours. Immunohistochemical markers of Leydig cell tumours include <a href="/wiki/Inhibin-alpha" class="mw-redirect" title="Inhibin-alpha">inhibin-alpha</a>, <a href="/wiki/Calretinin" title="Calretinin">calretinin</a>, and <a href="/wiki/Melan-A" class="mw-redirect" title="Melan-A">melan-A</a>.<sup id="cite_ref-pmid12409718_6-0" class="reference"><a href="#cite_note-pmid12409718-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=4" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The usual chemotherapy regimen has limited efficacy in tumours of this type, although <a href="/wiki/Imatinib" title="Imatinib">imatinib</a> has shown some promise.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> There is no current role for radiotherapy.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>The usual treatment is surgery. The surgery for females usually is a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed by surveillance. Because in many cases Leydig cell tumour does not produce elevated <a href="/wiki/Tumor_marker" title="Tumor marker">tumour markers</a>,<sup id="cite_ref-pmid17484630_9-0" class="reference"><a href="#cite_note-pmid17484630-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> the focus of surveillance is on repeated physical examination and imaging. </p><p>In males, a radical inguinal orchiectomy is typically performed. However, testes-sparing surgery can be used to maintain fertility in children and young adults. This approach involves an inguinal or scrotal incision and ultrasound guidance if the tumour is non-palpable. This can be done because the tumour is typically unifocal, not associated with precancerous lesions, and is unlikely to recur.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The <a href="/wiki/Prognosis" title="Prognosis">prognosis</a> is generally good as the tumour tends to grow slowly and usually is <a href="/wiki/Benign" class="mw-redirect" title="Benign">benign</a>: 10% are <a href="/wiki/Malignant" class="mw-redirect" title="Malignant">malignant</a>.<sup id="cite_ref-emedicine.medscape.com_3-1" class="reference"><a href="#cite_note-emedicine.medscape.com-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17284120_11-0" class="reference"><a href="#cite_note-pmid17284120-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> For malignant tumours with undifferentiated histology, prognosis is poor.<sup id="cite_ref-pmid17484630_9-1" class="reference"><a href="#cite_note-pmid17484630-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Additional_images">Additional images</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=5" title="Edit section: Additional images"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul class="gallery mw-gallery-packed"> <li class="gallerybox" style="width: 332px"> <div class="thumb" style="width: 330px;"><span typeof="mw:File"><a href="/wiki/File:Leydig_cell_tumour2.jpg" class="mw-file-description" title="Intermediate magnification micrograph of a Leydig cell tumour. H&E stain."><img alt="Intermediate magnification micrograph of a Leydig cell tumour. H&E stain." src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Leydig_cell_tumour2.jpg/495px-Leydig_cell_tumour2.jpg" decoding="async" width="330" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Leydig_cell_tumour2.jpg/743px-Leydig_cell_tumour2.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Leydig_cell_tumour2.jpg/990px-Leydig_cell_tumour2.jpg 2x" data-file-width="4272" data-file-height="2848" /></a></span></div> <div class="gallerytext">Intermediate magnification <a href="/wiki/Micrograph" title="Micrograph">micrograph</a> of a Leydig cell tumour. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>.</div> </li> <li class="gallerybox" style="width: 332px"> <div class="thumb" style="width: 330px;"><span typeof="mw:File"><a href="/wiki/File:Leydig_cell_tumour3.jpg" class="mw-file-description" title="High magnification micrograph of a Leydig cell tumour. H&E stain."><img alt="High magnification micrograph of a Leydig cell tumour. H&E stain." src="//upload.wikimedia.org/wikipedia/commons/thumb/9/95/Leydig_cell_tumour3.jpg/495px-Leydig_cell_tumour3.jpg" decoding="async" width="330" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/95/Leydig_cell_tumour3.jpg/743px-Leydig_cell_tumour3.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/95/Leydig_cell_tumour3.jpg/990px-Leydig_cell_tumour3.jpg 2x" data-file-width="4272" data-file-height="2848" /></a></span></div> <div class="gallerytext">High magnification <a href="/wiki/Micrograph" title="Micrograph">micrograph</a> of a Leydig cell tumour. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>.</div> </li> <li class="gallerybox" style="width: 230.66666666667px"> <div class="thumb" style="width: 228.66666666667px;"><span typeof="mw:File"><a href="/wiki/File:Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg" class="mw-file-description" title="Typical gross pathology of a Leydig cell tumor (in this case of the ovary): A well circumscribed, solid homogeneous mass with golden brown to brownish green cut surface.[12]"><img alt="Typical gross pathology of a Leydig cell tumor (in this case of the ovary): A well circumscribed, solid homogeneous mass with golden brown to brownish green cut surface.[12]" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg/343px-Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg" decoding="async" width="229" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg/515px-Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/44/Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg/686px-Gross_pathology_of_a_Leydig_cell_tumor_of_ovary.jpg 2x" data-file-width="999" data-file-height="961" /></a></span></div> <div class="gallerytext">Typical gross pathology of a Leydig cell tumor (in this case of the ovary): A well circumscribed, solid homogeneous mass with golden brown to brownish green cut surface.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></div> </li> </ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=6" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Androgen-dependent_syndromes" class="mw-redirect" title="Androgen-dependent syndromes">Androgen-dependent syndromes</a></li> <li><a href="/wiki/Sertoli_cell_tumour" title="Sertoli cell tumour">Sertoli cell tumour</a></li> <li><a href="/wiki/Sertoli%E2%80%93Leydig_cell_tumour" title="Sertoli–Leydig cell tumour">Sertoli–Leydig cell tumour</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=7" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFZhengshan_Chen,_M.D.,_Ph.D.,_Manju_Aron,_M.D." class="citation web cs1">Zhengshan Chen, M.D., Ph.D., Manju Aron, M.D. <a rel="nofollow" class="external text" href="https://www.pathologyoutlines.com/topic/testisleydig.html">"Testis & epididymis - Sex cord-stromal 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Minor changes: 12 April 2021.</span> </li> <li id="cite_note-pmid18382911-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid18382911_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSachdevaAroraDubeySukhija2008" class="citation journal cs1">Sachdeva P, Arora R, Dubey C, Sukhija A, Daga M, Singh DK (April 2008). "Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature". <i>Gynecol. 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Med</i>. <b>131</b> (2): <span class="nowrap">311–</span>7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.5858%2F2007-131-311-AILALC">10.5858/2007-131-311-AILALC</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17284120">17284120</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arch.+Pathol.+Lab.+Med.&rft.atitle=An+in-depth+look+at+Leydig+cell+tumor+of+the+testis&rft.volume=131&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E311-%3C%2Fspan%3E7&rft.date=2007-02&rft_id=info%3Adoi%2F10.5858%2F2007-131-311-AILALC&rft_id=info%3Apmid%2F17284120&rft.aulast=Al-Agha&rft.aufirst=OM&rft.au=Axiotis%2C+CA&rft_id=http%3A%2F%2Fjournals.allenpress.com%2Fjrnlserv%2F%3Frequest%3Dget-abstract%26issn%3D0003-9985%26volume%3D131%26page%3D311&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALeydig+cell+tumour" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhengshan_Chen,_M.D.,_Ph.D.,_Manju_Aron,_M.D." class="citation web cs1">Zhengshan Chen, M.D., Ph.D., Manju Aron, M.D. <a rel="nofollow" class="external text" href="https://www.pathologyoutlines.com/topic/testisleydig.html">"Testis & epididymis - Sex cord-stromal tumors - Leydig cell tumor"</a>. <i>PathologyOutlines</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=PathologyOutlines&rft.atitle=Testis+%26+epididymis+-+Sex+cord-stromal+tumors+-+Leydig+cell+tumor&rft.au=Zhengshan+Chen%2C+M.D.%2C+Ph.D.%2C+Manju+Aron%2C+M.D.&rft_id=https%3A%2F%2Fwww.pathologyoutlines.com%2Ftopic%2Ftestisleydig.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALeydig+cell+tumour" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/Template:Cite_web" title="Template:Cite web">cite web</a>}}</code>: CS1 maint: multiple names: authors list (<a href="/wiki/Category:CS1_maint:_multiple_names:_authors_list" title="Category:CS1 maint: multiple names: authors list">link</a>)</span> Topic Completed: 4 March 2021. Minor changes: 12 April 2021.</span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leydig_cell_tumour&action=edit&section=8" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 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dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-label="Navbox32" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q4000420" class="extiw" title="d:Q4000420">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a></b>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=183.0">183.0</a>, <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=256.1">256.1</a></li><li><b><a href="/wiki/International_Classification_of_Diseases_for_Oncology" title="International Classification of Diseases for Oncology">ICD-O</a></b>: 8631</li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D007984">D007984</a></li><li><b><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a></b>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb7445.htm">7445</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></b>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/medlineplus/ency/article/000409.htm">000409</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Tumors_of_the_female_urogenital_system146" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link 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li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Female_genital_neoplasia" title="Template:Female genital neoplasia"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Female_genital_neoplasia" title="Template talk:Female genital neoplasia"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Female_genital_neoplasia" title="Special:EditPage/Template:Female genital neoplasia"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Tumors_of_the_female_urogenital_system146" style="font-size:114%;margin:0 4em"><a href="/wiki/Tumor" class="mw-redirect" title="Tumor">Tumors</a> of the female <a href="/wiki/Urogenital_system" class="mw-redirect" title="Urogenital system">urogenital system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adnexa_of_uterus" class="mw-redirect" title="Adnexa of uterus">Adnexa</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ovarian_cancer" title="Ovarian cancer">Ovaries</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Glandular_and_epithelial_neoplasm&action=edit&redlink=1" class="new" title="Glandular and epithelial neoplasm (page does not exist)">Glandular and epithelial</a>/<br /><a href="/wiki/Surface_epithelial-stromal_tumor" title="Surface epithelial-stromal tumor">surface epithelial-<br />stromal tumor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="CMS:4" scope="row" class="navbox-group" style="width:1%">CMS:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ovarian_serous_cystadenoma" title="Ovarian serous cystadenoma">Ovarian serous cystadenoma</a></li> <li><a href="/wiki/Mucinous_cystadenoma" title="Mucinous cystadenoma">Mucinous cystadenoma</a></li> <li><a href="/wiki/Cystadenocarcinoma" title="Cystadenocarcinoma">Cystadenocarcinoma</a> <ul><li><a href="/wiki/Papillary_serous_cystadenocarcinoma" title="Papillary serous cystadenocarcinoma">Papillary serous cystadenocarcinoma</a></li></ul></li> <li><a href="/wiki/Krukenberg_tumor" title="Krukenberg tumor">Krukenberg tumor</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endometrioid_tumor" title="Endometrioid tumor">Endometrioid tumor</a></li> <li><a href="/wiki/Ovarian_clear-cell_carcinoma" title="Ovarian clear-cell carcinoma">Ovarian clear-cell carcinoma</a></li> <li><a href="/wiki/Brenner_tumour" title="Brenner tumour">Brenner tumour</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sex_cord%E2%80%93gonadal_stromal_tumour" title="Sex cord–gonadal stromal tumour">Sex cord–gonadal stromal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Leydig cell tumour</a></li> <li><a href="/wiki/Sertoli_cell_tumour" title="Sertoli cell tumour">Sertoli cell tumour</a></li> <li><a href="/wiki/Sertoli%E2%80%93Leydig_cell_tumour" title="Sertoli–Leydig cell tumour">Sertoli–Leydig cell tumour</a></li> <li><a href="/wiki/Thecoma" title="Thecoma">Thecoma</a></li> <li><a href="/wiki/Granulosa_cell_tumour" title="Granulosa cell tumour">Granulosa cell tumour</a></li> <li><a href="/wiki/Luteoma" title="Luteoma">Luteoma</a></li> <li><a href="/wiki/Sex_cord_tumour_with_annular_tubules" title="Sex cord tumour with annular tubules">Sex cord tumour with annular tubules</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Germ_cell_tumor" title="Germ cell tumor">Germ cell</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dysgerminoma" title="Dysgerminoma">Dysgerminoma</a></li> <li><a href="/wiki/Germ_cell_tumor#Nongerminomatous" title="Germ cell tumor">Nongerminomatous</a> <ul><li><a href="/wiki/Embryonal_carcinoma" title="Embryonal carcinoma">Embryonal carcinoma</a></li> <li><a href="/wiki/Endodermal_sinus_tumor" title="Endodermal sinus tumor">Endodermal sinus tumor</a></li> <li><a href="/wiki/Gonadoblastoma" title="Gonadoblastoma">Gonadoblastoma</a></li> <li><a href="/wiki/Teratoma" title="Teratoma">Teratoma</a>/<a href="/wiki/Struma_ovarii" title="Struma ovarii">Struma ovarii</a></li> <li><a href="/wiki/Choriocarcinoma" title="Choriocarcinoma">Choriocarcinoma</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ovarian_fibroma" title="Ovarian fibroma">Fibroma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Meigs%27_syndrome" class="mw-redirect" title="Meigs' syndrome">Meigs' syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fallopian_tube_cancer" title="Fallopian tube cancer">Fallopian tube</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenomatoid_tumor" title="Adenomatoid tumor">Adenomatoid tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Uterine_cancer" title="Uterine cancer">Uterus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myometrium" title="Myometrium">Myometrium</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Uterine_fibroid" title="Uterine fibroid">Uterine fibroids/leiomyoma</a></li> <li><a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">Leiomyosarcoma</a></li> <li><a href="/wiki/Adenomyoma" title="Adenomyoma">Adenomyoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endometrial_cancer" title="Endometrial cancer">Endometrium</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endometrioid_tumor" title="Endometrioid tumor">Endometrioid tumor</a></li> <li><a href="/wiki/Uterine_serous_carcinoma" title="Uterine serous carcinoma">Uterine papillary serous carcinoma</a></li> <li><a href="/wiki/Endometrial_intraepithelial_neoplasia" title="Endometrial intraepithelial neoplasia">Endometrial intraepithelial neoplasia</a></li> <li><a href="/wiki/Uterine_clear-cell_carcinoma" title="Uterine clear-cell carcinoma">Uterine clear-cell carcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cervical_cancer" title="Cervical cancer">Cervix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cervical_intraepithelial_neoplasia" title="Cervical intraepithelial neoplasia">Cervical intraepithelial neoplasia</a></li> <li><a href="/wiki/Clear-cell_adenocarcinoma_of_the_vagina" title="Clear-cell adenocarcinoma of the vagina">Clear-cell carcinoma</a></li> <li><a href="/wiki/Squamous-cell_carcinoma#Vagina_and_cervix" title="Squamous-cell carcinoma">SCC</a></li> <li><a href="/wiki/Glassy_cell_carcinoma_of_the_cervix" title="Glassy cell carcinoma of the cervix">Glassy-cell carcinoma</a></li> <li><a href="/wiki/Villoglandular_adenocarcinoma_of_the_cervix" title="Villoglandular adenocarcinoma of the cervix">Villoglandular adenocarcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Placenta" title="Placenta">Placenta</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Choriocarcinoma" title="Choriocarcinoma">Choriocarcinoma</a></li> <li><a href="/wiki/Gestational_trophoblastic_disease" title="Gestational trophoblastic disease">Gestational trophoblastic disease</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Uterine_sarcoma" title="Uterine sarcoma">Uterine sarcoma</a></li> <li><a href="/wiki/Mixed_M%C3%BCllerian_tumor" title="Mixed Müllerian tumor">Mixed Müllerian tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vaginal_cancer" title="Vaginal cancer">Vagina</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Squamous-cell_carcinoma_of_the_vagina" class="mw-redirect" title="Squamous-cell carcinoma of the vagina">Squamous-cell carcinoma of the vagina</a></li> <li><a href="/wiki/Sarcoma_botryoides" title="Sarcoma botryoides">Botryoid rhabdomyosarcoma</a></li> <li><a href="/wiki/Clear-cell_adenocarcinoma_of_the_vagina" title="Clear-cell adenocarcinoma of the vagina">Clear-cell adenocarcinoma of the vagina</a></li> <li><a href="/wiki/Vaginal_intraepithelial_neoplasia" title="Vaginal intraepithelial neoplasia">Vaginal intraepithelial neoplasia</a></li> <li><a href="/wiki/Vaginal_cysts" title="Vaginal cysts">Vaginal cysts</a></li></ul> </div></td></tr><tr><th scope="row" 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cancer">List of people with prostate cancer</a></li> <li><a href="/wiki/Small-cell_carcinoma#Prostate" title="Small-cell carcinoma">Small-cell carcinoma</a></li> <li><a href="/wiki/Transitional_cell_carcinoma#Prostate" title="Transitional cell carcinoma">Transitional-cell carcinoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Penile_cancer" title="Penile cancer">Penis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Penile_cancer" title="Penile cancer">Carcinoma</a> <ul><li><a href="/wiki/Extramammary_Paget%27s_disease" title="Extramammary Paget's disease">Extramammary Paget's disease</a></li></ul></li> <li><a href="/wiki/Bowen%27s_disease" class="mw-redirect" title="Bowen's disease">Bowen's disease</a></li> <li><a href="/wiki/Bowenoid_papulosis" title="Bowenoid papulosis">Bowenoid papulosis</a></li> <li><a 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