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Objective: This randomized, placebo-controlled, parallel-group, double-blind study was performed to assess the efficacy and safety of fexofenadine in children with seasonal allergic rhinitis. Methods: This study was conducted at 148 centers in 15 countries. Nine hundred thirty-five children (aged 6-11 years) were randomized and treated with either fexofenadine HCl 30 mg (n = 464) or placebo (n = 471) tablets twice a day for 14 days. Individual symptoms (sneezing; rhinorrhea; itchy nose, mouth, throat, and/or ears; itchy, watery, and/or red eyes; and nasal congestion) were assessed at baseline and then daily at 7:00 AM and 7:00 PM (±1 hour) during the double-blind treatment period. Each total symptom score was the sum of all symptoms, excluding nasal congestion. The primary efficacy variable was the change from baseline in the average of the daily 12-hour evening reflective total symptom scores throughout the double-blind treatment. Safety was evaluated from adverse-event reporting, vital signs, physical examinations, and clinical laboratory data at screening and study end point. Results: Fexofenadine was significantly superior to placebo in the primary efficacy analysis (P ≤ .0001). Individual symptom scores showed statistically significant superiority compared with placebo (P < .05), including nasal congestion in the evening reflective assessment (P < .05). There was no significant difference in adverse events between fexofenadine and placebo, either overall or by causality. Conclusion: The efficacy and safety of the H1-antihistamine fexofenadine has been confirmed in this multicenter, multinational study of children aged 6 to 11 years with seasonal allergic rhinitis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10231576" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="40878c6912e42674a8bbbdcbf1886046" rel="nofollow" data-download="{"attachment_id":47474541,"asset_id":10231576,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47474541/download_file?st=MTczMjM3MzI1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="25029555" href="https://independent.academia.edu/JoseRosado3">Jose Rosado</a><script data-card-contents-for-user="25029555" type="text/json">{"id":25029555,"first_name":"Jose","last_name":"Rosado","domain_name":"independent","page_name":"JoseRosado3","display_name":"Jose Rosado","profile_url":"https://independent.academia.edu/JoseRosado3?f_ri=1826493","photo":"https://0.academia-photos.com/25029555/6790844/7667382/s65_jose.rosado.jpg_oh_67b6aba331d7391d999465c82da6fee3_oe_55264a09___gda___1432348824_67cfb3a6e9d48120368db1653cb02e65"}</script></span></span></li><li class="js-paper-rank-work_10231576 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10231576"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10231576, container: ".js-paper-rank-work_10231576", }); 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$(".js-view-count[data-work-id=10231576]").text(description); $(".js-view-count-work_10231576").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_10231576").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="10231576"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a>, <script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=1826493","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10231576]'), work: {"id":10231576,"title":"Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis","created_at":"2015-01-19T08:12:48.983-08:00","url":"https://www.academia.edu/10231576/Fexofenadine_is_efficacious_and_safe_in_children_aged_6_11_years_with_seasonal_allergic_rhinitis?f_ri=1826493","dom_id":"work_10231576","summary":"Background: This is the first prospective, randomized, double-blind, placebo-controlled study showing statistical improvement of an H1-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period. Objective: This randomized, placebo-controlled, parallel-group, double-blind study was performed to assess the efficacy and safety of fexofenadine in children with seasonal allergic rhinitis. Methods: This study was conducted at 148 centers in 15 countries. Nine hundred thirty-five children (aged 6-11 years) were randomized and treated with either fexofenadine HCl 30 mg (n = 464) or placebo (n = 471) tablets twice a day for 14 days. Individual symptoms (sneezing; rhinorrhea; itchy nose, mouth, throat, and/or ears; itchy, watery, and/or red eyes; and nasal congestion) were assessed at baseline and then daily at 7:00 AM and 7:00 PM (±1 hour) during the double-blind treatment period. Each total symptom score was the sum of all symptoms, excluding nasal congestion. The primary efficacy variable was the change from baseline in the average of the daily 12-hour evening reflective total symptom scores throughout the double-blind treatment. Safety was evaluated from adverse-event reporting, vital signs, physical examinations, and clinical laboratory data at screening and study end point. Results: Fexofenadine was significantly superior to placebo in the primary efficacy analysis (P ≤ .0001). Individual symptom scores showed statistically significant superiority compared with placebo (P \u003c .05), including nasal congestion in the evening reflective assessment (P \u003c .05). There was no significant difference in adverse events between fexofenadine and placebo, either overall or by causality. Conclusion: The efficacy and safety of the H1-antihistamine fexofenadine has been confirmed in this multicenter, multinational study of children aged 6 to 11 years with seasonal allergic rhinitis.","downloadable_attachments":[{"id":47474541,"asset_id":10231576,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25029555,"first_name":"Jose","last_name":"Rosado","domain_name":"independent","page_name":"JoseRosado3","display_name":"Jose Rosado","profile_url":"https://independent.academia.edu/JoseRosado3?f_ri=1826493","photo":"https://0.academia-photos.com/25029555/6790844/7667382/s65_jose.rosado.jpg_oh_67b6aba331d7391d999465c82da6fee3_oe_55264a09___gda___1432348824_67cfb3a6e9d48120368db1653cb02e65"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=1826493","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=1826493","nofollow":false},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=1826493"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=1826493"},{"id":125564,"name":"Statistical Significance","url":"https://www.academia.edu/Documents/in/Statistical_Significance?f_ri=1826493"},{"id":425873,"name":"Adverse Event","url":"https://www.academia.edu/Documents/in/Adverse_Event?f_ri=1826493"},{"id":516735,"name":"Physical examination","url":"https://www.academia.edu/Documents/in/Physical_examination?f_ri=1826493"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=1826493"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24792670" data-work_id="24792670" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24792670/Exploring_the_repertoire_of_IgE_binding_self_antigens_associated_with_atopic_eczema">Exploring the 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u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a>, <script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="98925" href="https://www.academia.edu/Documents/in/Female">Female</a><script data-card-contents-for-ri="98925" type="text/json">{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=1826493","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24792670]'), work: {"id":24792670,"title":"Exploring the repertoire of IgE-binding self-antigens associated with atopic 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u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/729347/The_European_Union_CREATE_Project_A_model_for_international_standardization_of_allergy_diagnostics_and_vaccines">The European Union CREATE Project: A model for international standardization of allergy diagnostics and vaccines</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/729347" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="affff05c1c30781c0c9e14df4ee5ea3e" rel="nofollow" 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itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="59869029" href="https://independent.academia.edu/LiebermanAllan">Allan Lieberman</a><script data-card-contents-for-user="59869029" type="text/json">{"id":59869029,"first_name":"Allan","last_name":"Lieberman","domain_name":"independent","page_name":"LiebermanAllan","display_name":"Allan Lieberman","profile_url":"https://independent.academia.edu/LiebermanAllan?f_ri=1826493","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72257998 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72257998"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72257998, container: ".js-paper-rank-work_72257998", }); });</script></li><li class="js-percentile-work_72257998 InlineList-item InlineList-item--bordered 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type="text/json">{"id":9109,"name":"Tobacco","url":"https://www.academia.edu/Documents/in/Tobacco?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a><script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=1826493","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12796076]'), work: {"id":12796076,"title":"Smoking might be a risk factor for contact 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Most patients with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18902809" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In patients given a diagnosis of chronic spontaneous urticaria (CSU), there are no obvious external triggers, and the factors that initiate the clinical symptoms of wheal, flare, and itch arise from within the patient. Most patients with CSU have an autoimmune cause: some patients produce IgE autoantibodies against autoantigens, such as thyroperoxidase or double-stranded DNA, whereas other patients make IgG autoantibodies against FcεRI, IgE, or both, which might chronically activate mast cells and basophils. In the remainder of patients with CSU, the nature of the abnormalities has not yet been identified. Accumulating evidence has shown that IgE, by binding to FcεRI on mast cells without FcεRI cross-linking, can promote the proliferation and survival of mast cells and thus maintain and expand the pool of mast cells. IgE and FcεRI engagement can also decrease the release threshold of mast cells and increase their sensitivity to various stimuli through either FcεRI or other receptors...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18902809" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a2b8f7426808c584762569e4484aa5f2" rel="nofollow" data-download="{"attachment_id":40319997,"asset_id":18902809,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40319997/download_file?st=MTczMjM3MzI1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39027220" href="https://charite-de.academia.edu/MarcusMaurer">Marcus Maurer</a><script data-card-contents-for-user="39027220" type="text/json">{"id":39027220,"first_name":"Marcus","last_name":"Maurer","domain_name":"charite-de","page_name":"MarcusMaurer","display_name":"Marcus Maurer","profile_url":"https://charite-de.academia.edu/MarcusMaurer?f_ri=1826493","photo":"https://0.academia-photos.com/39027220/11464973/12787791/s65_marcus.maurer.jpg"}</script></span></span></li><li class="js-paper-rank-work_18902809 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18902809"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18902809, container: ".js-paper-rank-work_18902809", }); 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$(".js-view-count-work_14292367").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14292367"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1691469" href="https://www.academia.edu/Documents/in/Severe_combined_immunodeficiency">Severe combined immunodeficiency</a>, <script data-card-contents-for-ri="1691469" type="text/json">{"id":1691469,"name":"Severe combined immunodeficiency","url":"https://www.academia.edu/Documents/in/Severe_combined_immunodeficiency?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1826493" href="https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology">Clinical Allergy and Immunology</a><script data-card-contents-for-ri="1826493" type="text/json">{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=1826493","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14292367]'), work: {"id":14292367,"title":"Enrichment of the rare CD4+ γδ T-cell subset in patients with atypical CD3δ deficiency","created_at":"2015-07-22T07:04:23.404-07:00","url":"https://www.academia.edu/14292367/Enrichment_of_the_rare_CD4_%CE%B3%CE%B4_T_cell_subset_in_patients_with_atypical_CD3%CE%B4_deficiency?f_ri=1826493","dom_id":"work_14292367","summary":null,"downloadable_attachments":[{"id":44349991,"asset_id":14292367,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33253909,"first_name":"Paul","last_name":"Fisch","domain_name":"independent","page_name":"PaulFisch","display_name":"Paul Fisch","profile_url":"https://independent.academia.edu/PaulFisch?f_ri=1826493","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false},{"id":1691469,"name":"Severe combined immunodeficiency","url":"https://www.academia.edu/Documents/in/Severe_combined_immunodeficiency?f_ri=1826493","nofollow":false},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=1826493","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22818175" data-work_id="22818175" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22818175/94_In_utero_exposure_to_tobacco_smoke">94 In utero exposure to tobacco smoke</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22818175" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eec79a234f246be23de064418fea2187" rel="nofollow" data-download="{"attachment_id":43365862,"asset_id":22818175,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43365862/download_file?st=MTczMjM3MzI1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44307734" href="https://independent.academia.edu/ElhamHossny">Elham Hossny</a><script data-card-contents-for-user="44307734" type="text/json">{"id":44307734,"first_name":"Elham","last_name":"Hossny","domain_name":"independent","page_name":"ElhamHossny","display_name":"Elham Hossny","profile_url":"https://independent.academia.edu/ElhamHossny?f_ri=1826493","photo":"https://0.academia-photos.com/44307734/17953184/17965154/s65_elham.hossny.jpg"}</script></span></span></li><li class="js-paper-rank-work_22818175 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22818175"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22818175, container: ".js-paper-rank-work_22818175", }); });</script></li><li class="js-percentile-work_22818175 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22818175; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_22818175"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_22818175 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="22818175"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22818175; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22818175]").text(description); $(".js-view-count-work_22818175").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22818175").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22818175"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="786557" href="https://www.academia.edu/Documents/in/Tobacco_Smoke">Tobacco Smoke</a>, <script data-card-contents-for-ri="786557" type="text/json">{"id":786557,"name":"Tobacco Smoke","url":"https://www.academia.edu/Documents/in/Tobacco_Smoke?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1321184" href="https://www.academia.edu/Documents/in/In_Utero_Exposure">In Utero Exposure</a>, <script data-card-contents-for-ri="1321184" type="text/json">{"id":1321184,"name":"In Utero Exposure","url":"https://www.academia.edu/Documents/in/In_Utero_Exposure?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1826493" href="https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology">Clinical Allergy and Immunology</a><script data-card-contents-for-ri="1826493" type="text/json">{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=1826493","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22818175]'), work: {"id":22818175,"title":"94 In utero exposure to tobacco smoke","created_at":"2016-03-04T13:04:58.284-08:00","url":"https://www.academia.edu/22818175/94_In_utero_exposure_to_tobacco_smoke?f_ri=1826493","dom_id":"work_22818175","summary":null,"downloadable_attachments":[{"id":43365862,"asset_id":22818175,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44307734,"first_name":"Elham","last_name":"Hossny","domain_name":"independent","page_name":"ElhamHossny","display_name":"Elham Hossny","profile_url":"https://independent.academia.edu/ElhamHossny?f_ri=1826493","photo":"https://0.academia-photos.com/44307734/17953184/17965154/s65_elham.hossny.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false},{"id":786557,"name":"Tobacco Smoke","url":"https://www.academia.edu/Documents/in/Tobacco_Smoke?f_ri=1826493","nofollow":false},{"id":1321184,"name":"In Utero Exposure","url":"https://www.academia.edu/Documents/in/In_Utero_Exposure?f_ri=1826493","nofollow":false},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=1826493","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16595614" data-work_id="16595614" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16595614/Ecology_and_elimination_of_cockroaches_and_allergens_in_the_home">Ecology and elimination of cockroaches and allergens in the home</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cockroach infestations have been indicated as a major contributor to asthma throughout the world. Several studies have shown that large numbers of asthmatic patients are sensitized to cockroach allergens. Eliminating this pest from homes,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16595614" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cockroach infestations have been indicated as a major contributor to asthma throughout the world. Several studies have shown that large numbers of asthmatic patients are sensitized to cockroach allergens. Eliminating this pest from homes, schools, and public buildings involves a long-term commitment to a rational extermination process. This article covers the characteristics of the major cockroach species that invade homes, assesses the role of environmental exposure to cockroaches in asthma, and provides an intervention program for their extermination.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16595614" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="db7526c990c4169eb4e4c6fa634dee68" rel="nofollow" data-download="{"attachment_id":42429223,"asset_id":16595614,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42429223/download_file?st=MTczMjM3MzI1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35922347" href="https://independent.academia.edu/PeytonEggleston">Peyton Eggleston</a><script data-card-contents-for-user="35922347" type="text/json">{"id":35922347,"first_name":"Peyton","last_name":"Eggleston","domain_name":"independent","page_name":"PeytonEggleston","display_name":"Peyton Eggleston","profile_url":"https://independent.academia.edu/PeytonEggleston?f_ri=1826493","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16595614 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16595614"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16595614, container: ".js-paper-rank-work_16595614", }); });</script></li><li class="js-percentile-work_16595614 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16595614; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16595614"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16595614 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16595614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16595614; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16595614]").text(description); $(".js-view-count-work_16595614").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16595614").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16595614"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a>, <script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1826493","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="168977" href="https://www.academia.edu/Documents/in/Allergens">Allergens</a><script data-card-contents-for-ri="168977" type="text/json">{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=1826493","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16595614]'), work: {"id":16595614,"title":"Ecology and elimination of cockroaches and allergens in the home","created_at":"2015-10-09T04:58:02.578-07:00","url":"https://www.academia.edu/16595614/Ecology_and_elimination_of_cockroaches_and_allergens_in_the_home?f_ri=1826493","dom_id":"work_16595614","summary":"Cockroach infestations have been indicated as a major contributor to asthma throughout the world. Several studies have shown that large numbers of asthmatic patients are sensitized to cockroach allergens. Eliminating this pest from homes, schools, and public buildings involves a long-term commitment to a rational extermination process. This article covers the characteristics of the major cockroach species that invade homes, assesses the role of environmental exposure to cockroaches in asthma, and provides an intervention program for their extermination.","downloadable_attachments":[{"id":42429223,"asset_id":16595614,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35922347,"first_name":"Peyton","last_name":"Eggleston","domain_name":"independent","page_name":"PeytonEggleston","display_name":"Peyton Eggleston","profile_url":"https://independent.academia.edu/PeytonEggleston?f_ri=1826493","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=1826493","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=1826493","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=1826493","nofollow":false},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=1826493","nofollow":false},{"id":190744,"name":"Cockroaches","url":"https://www.academia.edu/Documents/in/Cockroaches?f_ri=1826493"},{"id":295244,"name":"Indoor air pollution","url":"https://www.academia.edu/Documents/in/Indoor_air_pollution?f_ri=1826493"},{"id":1312021,"name":"Environmental Exposure","url":"https://www.academia.edu/Documents/in/Environmental_Exposure?f_ri=1826493"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=1826493"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_69915491" data-work_id="69915491" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/69915491/Human_CD40_ligand_deficiency_dysregulates_the_macrophage_transcriptome_causing_functional_defects_that_are_improved_by_exogenous_IFN_%CE%B3">Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-γ</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">CD40 ligand (CD40L) deficiency predisposes to opportunistic infections, including those caused by fungi and intracellular bacteria. Studies of CD40L-deficient patients reveal the critical role of CD40L-CD40 interaction for the function of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69915491" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">CD40 ligand (CD40L) deficiency predisposes to opportunistic infections, including those caused by fungi and intracellular bacteria. Studies of CD40L-deficient patients reveal the critical role of CD40L-CD40 interaction for the function of T, B, and dendritic cells. However, the consequences of CD40L deficiency on macrophage function remain to be investigated. We sought to determine the effect of CD40L absence on monocyte-derived macrophage responses. After observing the improvement of refractory disseminated mycobacterial infection in a CD40L-deficient patient by recombinant human IFN-γ (rhIFN-γ) adjuvant therapy, we investigated macrophage functions from CD40L-deficient patients. We analyzed the killing activity, oxidative burst, cytokine production, and in vitro effects of rhIFN-γ and soluble CD40 ligand (sCD40L) treatment on macrophages. In addition, the effect of CD40L absence on the macrophage transcriptome before and after rhIFN-γ treatment was studied. Macrophages from CD40L-...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69915491" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8c2014b586724efb7e2b223e933089a3" rel="nofollow" data-download="{"attachment_id":79830139,"asset_id":69915491,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79830139/download_file?st=MTczMjM3MzI1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="192937148" href="https://independent.academia.edu/AntonioCondinoNeto">Antonio Condino-Neto</a><script data-card-contents-for-user="192937148" type="text/json">{"id":192937148,"first_name":"Antonio","last_name":"Condino-Neto","domain_name":"independent","page_name":"AntonioCondinoNeto","display_name":"Antonio Condino-Neto","profile_url":"https://independent.academia.edu/AntonioCondinoNeto?f_ri=1826493","photo":"https://0.academia-photos.com/192937148/55721936/43906093/s65_antonio.condino-neto.jpeg"}</script></span></span></li><li class="js-paper-rank-work_69915491 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69915491"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69915491, container: ".js-paper-rank-work_69915491", }); 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Studies of CD40L-deficient patients reveal the critical role of CD40L-CD40 interaction for the function of T, B, and dendritic cells. However, the consequences of CD40L deficiency on macrophage function remain to be investigated. We sought to determine the effect of CD40L absence on monocyte-derived macrophage responses. After observing the improvement of refractory disseminated mycobacterial infection in a CD40L-deficient patient by recombinant human IFN-γ (rhIFN-γ) adjuvant therapy, we investigated macrophage functions from CD40L-deficient patients. We analyzed the killing activity, oxidative burst, cytokine production, and in vitro effects of rhIFN-γ and soluble CD40 ligand (sCD40L) treatment on macrophages. In addition, the effect of CD40L absence on the macrophage transcriptome before and after rhIFN-γ treatment was studied. Macrophages from CD40L-...","downloadable_attachments":[{"id":79830139,"asset_id":69915491,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":192937148,"first_name":"Antonio","last_name":"Condino-Neto","domain_name":"independent","page_name":"AntonioCondinoNeto","display_name":"Antonio 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[DNA-PK]) crucial for DNA double-strand break repair and V(D)J recombination. In mice DNA-PK... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12858599" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">PRKDC encodes for DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a kinase that forms part of a complex (DNA-dependent protein kinase [DNA-PK]) crucial for DNA double-strand break repair and V(D)J recombination. In mice DNA-PK also interacts with the transcription factor autoimmune regulator (AIRE) to promote central T-cell tolerance. We sought to understand the causes of an inflammatory disease with granuloma and autoimmunity associated with decreasing T- and B-cell counts over time that had been diagnosed in 2 unrelated patients. Genetic, molecular, and functional analyses were performed to characterize an inflammatory disease evocative of a combined immunodeficiency. We identified PRKDC mutations in both patients. These patients exhibited a defect in DNA double-strand break repair and V(D)J recombination. Whole-blood mRNA analysis revealed a strong interferon signature. On activation, memory T cells displayed a skewed cytokine response typical of TH2 and TH1 but not TH...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12858599" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ceb563c8dd415dcbc8a7108ea0707949" rel="nofollow" data-download="{"attachment_id":45885637,"asset_id":12858599,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45885637/download_file?st=MTczMjM3MzI1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31977875" href="https://independent.academia.edu/CapucinePicard">Capucine Picard</a><script data-card-contents-for-user="31977875" type="text/json">{"id":31977875,"first_name":"Capucine","last_name":"Picard","domain_name":"independent","page_name":"CapucinePicard","display_name":"Capucine Picard","profile_url":"https://independent.academia.edu/CapucinePicard?f_ri=1826493","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12858599 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12858599"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12858599, container: ".js-paper-rank-work_12858599", }); 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In mice DNA-PK also interacts with the transcription factor autoimmune regulator (AIRE) to promote central T-cell tolerance. We sought to understand the causes of an inflammatory disease with granuloma and autoimmunity associated with decreasing T- and B-cell counts over time that had been diagnosed in 2 unrelated patients. Genetic, molecular, and functional analyses were performed to characterize an inflammatory disease evocative of a combined immunodeficiency. We identified PRKDC mutations in both patients. These patients exhibited a defect in DNA double-strand break repair and V(D)J recombination. Whole-blood mRNA analysis revealed a strong interferon signature. 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