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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-8CT98BPDP3"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-8CT98BPDP3", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="The Lung Cancer Program at BC Cancer strives to decrease the incidence and mortality of lung cancer and improve the quality of life of lung cancer patients through a comprehensive strategy of prevention, early detection, timely diagnosis and personalized therapy." /> <link rel="canonical" href="https://www.bccrc.ca/dept/io/programs/lung-cancer-program" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" 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id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Lung Cancer Program</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--program full has-footer"> <div class="node__inner"> <footer class="node"> <div class="field field--field_cancer"> <div class="above field--label">Cancer Type</div> <div> <div class="field field--item field--field_cancer"><a href="/dept/io/taxonomy/term/48" hreflang="und">Lung</a></div> </div> </div> </footer> <div class="node__main"> <div class="field field--body"><p>The Lung Cancer Program at BC Cancer strives to decrease the incidence and mortality of lung cancer and improve the quality of life of lung cancer patients through a comprehensive strategy of prevention, early detection, timely diagnosis and personalized therapy.</p> <p><strong>What are the Lung Cancer Program’s goals:</strong></p> <ol> <li>Implement smoking cessation program in all centers within 2 years</li> <li>Implement province-wide lung cancer screening</li> <li>Improve 5-year survival from 18% to 50% within 10 years</li> <li>Improve the patient & family experience in lung cancer journey</li> <li>Translation of laboratory research to patient care</li> </ol> <p><strong>Improving the Lung Cancer Patient Experience</strong>:</p> <ul> <li>Rapid access Lung Evaluation and Assessment program (LEAP) with nurse navigators</li> <li>OASIS – lung cancer registry and outcome unit</li> <li>Lung cancer biobank with blood and tissue for future biomarker testing</li> </ul> <p><strong>The purpose of the Lung Cancer Biobank (LUTTISSUE):</strong></p> <ul> <li>To establish an archival tissue bank from tissue remaining after central biomarker testing is completed at the Vancouver Centre.</li> <li>To allow BC Cancer Agency (BCCA) investigators to conduct future correlative studies relating tissue biomarker status to patient outcomes.</li> </ul> <p><strong>Research Milestones:  New Drug Targets and Overcoming Treatment Resistance</strong></p> <ol> <li>Established a new approach to targeted therapy through hyperactivation of mutually exclusive oncogenic mutations in cancer cells through inhibition of DUSP6 phosphatase that restrain ERK activity in tumours with EGFR or KRAS oncogene mutation</li> <li>GGA2 has been identified as an essential co-operator of mutant EGFR-mediated lung tumorigenesis and development of TKI resistance. Inhibition of GGA2 sensitizes mutant EGFR lung cancers to tyrosine kinase inhibitors. Use of combination therapies of GGA2 and TKI tocircumvent resistance will be further tested.</li> <li>Discovered resistance to MET kinase inhibitors was found to be due to acquired KRAS mutations. Targeting downstream components of KRAS in conjunction with MET TKI offer a new strategy to combat drug resistance.</li> <li>Discovered inhibition of PAPSS1 gene sensitizes lung cancer cells to cisplatin treatment offering a strategy to improve efficacy of chemotherapy</li> <li>Revealed the mechanism of action of a novel small molecule called LCS3 for lung cancer treatment using high-throughput screens. LCS3 acutely activates reactive oxygen species production in lung cancer cells but not normal lung cells.</li> <li>Identified RNA based biomarkers for distinguishing mesothelioma from metastatic lung cancer</li> <li>Identified 3 Oncofetal genes as new targets for treatment of adenocarcinoma</li> <li>Identified new target against E2F for small cell lung cancer treatment</li> <li>Identified non-coding RNAs to predict recurrence-free survival</li> </ol> <p><strong>Who are we?</strong></p> <p><strong>Program Leaders: </strong></p> <p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="d89148a6-81d2-4d26-a44c-724293676187" href="https://www.bccrc.ca/dept/io/people/stephen-lam" title="Stephen Lam">Dr. Stephen Lam</a> & Dr. Barbara Melosky</p> <p><strong>Clinician Scientists: </strong></p> <p>Stephen Lam, Janessa Laskin, Renelle Myers, Ren Yuan, Diana Ionescu; Anna McGuire</p> <p><strong>Researchers: </strong></p> <p>Calum MacAualy, Wan Lam, Will Lockwood, Kevin Benewith, Haishan Zeng, Pierre Lane, Martial Guillaud, Sonya Cressman</p></div> </div> </div> </article> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. Together with our donors, we are changing cancer outcomes for British Columbians by funding innovative research and personalized treatment and care.</p> <p><a class="button" href="https://bccancerfoundation.com/donations/general-donation-form/?s_src=BCCRCFooter" target="_blank">Donate Today</a></p></div> </section> </div> </section> <footer class="page" role="contentinfo"> <section class="region region__footer"> <div class="region__footer--inner region--inner"> <section id="block-bccrc-branding" class="block block--system-branding-block block-bccrc-branding"> <a href="/dept/io/dept/io/" title="Home" rel="home"> <img src="/dept/io/dept/io/sites/integrativeoncology/files/BCClogo_Research_IntegrativeOncology_RGB.png" alt="Home" /> </a> </section> <section id="block-contactus" class="block block--block-content2314a90f-9af6-4a1e-8cf5-6a294688e075 block--contact-us block-contactus"> <h2 class="section__title">Contact Us</h2> <div class="field field--body"><p>BC Cancer Research Institute<br> 675 West 10th Avenue<br> Vancouver, BC V5Z 1L3</p> <p>604 675 8000</p> <p>Toll Free: 1 888 675 8001</p></div> </section> <section id="block-followus" class="block block--block-content06fb6d8a-948b-4134-bf4f-c16a4f797215 block--follow-us block-followus"> <h2 class="section__title">Follow Us</h2> <div class="field field--body"><p><a class="fa fa-linkedin" href="https://www.linkedin.com/company/bc-cancer/"> </a><a class="fa fa-twitter" href="https://twitter.com/BCCancer"> </a><a class="fa fa-instagram" href="https://www.instagram.com/bccancer/"> </a></p></div> </section> <section id="block-phsa" class="block block--block-content609d9708-6063-4709-9c42-0fa2c2589d0d block-phsa"> <div class="field field--body"><p><a href="http://www.phsa.ca" target="_blank"><img alt="PHSA" src="https://www.bccrc.ca/dept/io/sites/integrativeoncology/files/PHSA-logo.svg"></a></p></div> </section> </div> </section> </footer> <section class="region region__copyright"> <div class="region__copyright--inner region--inner"> <nav role="navigation" aria-labelledby="block-bccrc-footer-menu" id="block-bccrc-footer"> <h2 class="visually-hidden" id="block-bccrc-footer-menu">Footer menu</h2> <ul class="menu"> <li class="menu-item"> <a href="http://www.phsa.ca/privacy">Privacy Policy</a> </li> <li>Copyright © BC Cancer. 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