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}) })(jQuery); </script> </head> <body class="post-template-default single single-post postid-543 single-format-standard header-image full-width-content genesis-breadcrumbs-visible"><div class="site-container"><header class="site-header"><div class="wrap"><div class="title-area"><p class="site-title"><a href="https://www.thermofisher.com/" title="Thermo Fisher Scientific">Thermo Fisher Scientific</a></p><p class="site-description">Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology</p></div><div class="widget-area header-widget-area"><section id="block-5" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> <section id="block-6" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> </div><div class="breadcrumb"><span class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/"><span class="breadcrumb-link-text-wrap">Life in Atomic Resolution</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/cryo-electron-microscopy-cryo-em/"><span class="breadcrumb-link-text-wrap">Cryo-Electron Microscopy (Cryo-EM)</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Cryo-Electron Tomography and 3D Software Advances Coronavirus Research</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-543 post type-post status-publish format-standard has-post-thumbnail category-cryo-electron-microscopy-cryo-em category-cryo-electron-tomography category-general category-software tag-amira tag-cryo-electron-microscopy tag-cryo-electron-tomography tag-cryo-em tag-software entry" aria-label="Cryo-Electron Tomography and 3D Software Advances Coronavirus Research"><header class="entry-header"><h1 class="entry-title">Cryo-Electron Tomography and 3D Software Advances Coronavirus Research</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/sbaillet/" title="Posts by Séverine Baillet" rel="author">Séverine Baillet</a> </span> <span class="post-info-date"> 03.19.2021 </span> </header><div class="entry-content"><p>Over the last year, researchers turned to cryo-electron microscopy (cryo-EM) to increase the human understanding of the SARS-CoV-2 virus, as they have done with <a title="Learn more about cryo-EM applications with other major viruses" href="https://ter.li/0e9jqm" target="_blank" rel="noopener">other major viruses like Zika, Ebola, and Human Immunodeficiency Virus</a>. Our cryo-EM instruments, including the Krios Cryo-TEM, have been used for breakthrough coronavirus research findings, such as <a title="Read more about the research" href="https://www.nature.com/articles/s41467-020-19619-7" target="_blank" rel="noopener">one recently published</a> by a team of researchers at Heidelberg University.</p> <h2 style="font-size: 100%"><strong>Coronavirus Research Fueled by Powerful Imaging</strong></h2> <p>In 2020, this team quickly set out to understand how the virus changes infected cells to achieve effective reproduction and made significant headway by characterizing the replication of SARS-CoV-2 inside host cells.</p> <p>Using <a title="Learn more about cryo electron tomography" href="https://ter.li/xmqaqj" target="_blank" rel="noopener">cryo electron tomography</a> (cryo-ET), a cryo-electron microscopy technique that provides three-dimensional images of molecular structures at nanometer resolution, the researchers revealed how SARS-CoV-2 changes the cellular membranes and organelles of infected cells, which is critical for effective replication.</p> <p><img decoding="async" class="aligncenter wp-image-1676" title="SARS-CoV-2 virus particles rendered during coronavirus research" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/04/Heidelberg-inline.jpg" alt="SARS-CoV-2 virus particles rendered during coronavirus research" width="400" height="492" /></p> <div align="center"><em>Combining cryo-electron tomography with Thermo Scientific Amira Software, a team of Heidelberg University researchers was able to render the three-dimensional environment of the cell and visualize individual SARS-CoV-2 virus particles and details of the viral assembly sites. (Photo of coronavirus research results courtesy of Heidelberg University)</em></div> <p>The researchers performed molecular analyses of the viral RNA and individual steps of virus replication to obtain unprecedented detail of the network composed of double-stranded RNA inside the double-membrane vesicles.</p> <h2 style="font-size: 100%"><strong>Cryo-Electron Tomography of Infected Cells</strong></h2> <p>Using in-situ cryo-ET to image 200-nanometer thin layers of virus-infected cells, the researchers discovered how the viral RNA creates the necessary factors for its replication, allowing it to quickly reproduce and possibly even protect itself against immune system attacks. Using our Thermo Scientific <a title="Learn more about our Krios cryo-TEM" href="https://ter.li/qzataa" target="_blank" rel="noopener">Krios Cryo-TEM</a> and <a title="Learn more about our Aquilos Cryo-FIB" href="https://ter.li/cnicyy" target="_blank" rel="noopener">Aquilos Cryo-FIB</a> in combination with <a title="Learn more about our Amira Software" href="https://ter.li/v1t6ak" target="_blank" rel="noopener">Thermo Scientific Amira Software</a>, they rendered the three-dimensional environment of the cell—while visualizing individual virus particles and details of the virus assembly sites.</p> <p>These discoveries built on the team’s previous experience studying viral infections such as Influenza A and Ebola. “Thanks to our expertise in cryo-electron tomography, the excellent microscopes at the campus of Heidelberg University, and the highly collaborative environment at the Center for Integrative Infectious Disease Research, we were able to start detailed molecular examinations on SARS-CoV-2 infected cells right at the beginning of the coronavirus pandemic,” <a title="Read the article" href="https://analyticalscience.wiley.com/do/10.1002/was.00020233" target="_blank" rel="noopener">said Heidelberg University Hospital researcher Dr. Petr Chlanda</a>.</p> <p>The researchers’ next step with their coronavirus research is to uncover which proteins are involved in the formation of the double membrane structures. Characterizing the replication cycle of SARS-CoV-2 inside the host cell is key to developing drugs that restrict their reproduction—and the Heidelberg University researchers have brought us a big step closer to that goal.</p> <p>Read our <a title="Read the customer testimonial from Heidelberg University" href="https://www.thermofisher.com/us/en/home/global/forms/industrial/heidelberg-university-uses-amira-software.html" target="_blank" rel="noopener">customer spotlight</a> to learn more.</p> <p>//</p> <p><em>Séverine Baillet, PhD, is a marketing project manager at Thermo Fisher Scientific.</em></p> <p>Speak with an expert: <a title="Speak with an expert" href="https://www.thermofisher.com/blog/microscopy/speak-with-an-expert/" rel="noopener">https://www.thermofisher.com/blog/microscopy/speak-with-an-expert/</a></p> <p><a title="Subscribe to our blog" href="https://www.thermofisher.com/blog/microscopy/subscribe-to-accelerating-microscopy/" rel="noopener">Subscribe now</a> to receive 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