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KEGG DRUG: Tapentadol hydrochloride
<!doctype html> <html><head> <title>KEGG DRUG: Tapentadol hydrochloride</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1746558407"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1746558407"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1746558407" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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} } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="650"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D10199"></a><font class="title5">DRUG: Tapentadol hydrochloride</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D10199 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Tapentadol hydrochloride (JAN);<br>Nucynta (TN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td50 defd"><div class="cel"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=80938c30-9fe3-4c7d-9d9c-5476638cfb2d">NUCYNTA (Collegium Pharmaceutical)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c3d04d70-0155-4147-9ce4-a3b1fad4b373">NUCYNTA (Collegium Pharmaceutical)</a></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td51 defd"><div class="cel">C14H23NO. HCl<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td50 defd"><div class="cel">257.1546<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td51 defd"><div class="cel">257.80<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td50 defd"><a href="/Fig/drug/D10199.gif"><img name="img0" src="/Fig/drug/D10199.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D10199';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D10199';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D10199&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D10199';return false;">Neighbor</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td50 defd"><div class="cel"><span class="nowrap">Neuropsychiatric agent<br> <a href="/entry/DG01564">DG01564</a> Opioid receptor agonist<br> <a href="/entry/DG01563">DG01563</a> mu-Opioid receptor agonist<br> Analgesic<br> <a href="/entry/DG01984">DG01984</a> Opioid analgesics<br> Metabolizing enzyme substrate<br> <a href="/entry/DG02924">DG02924</a> UGT substrate<br> </span></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Therapeutic category: </span></td><td><a href="/brite/br08301+D10199">8219</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D10199">N02AX06</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Chemical structure group: </span></td><td><a href="/entry/DG00826">DG00826</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product (DG00826): </span></td><td>D10199<US> </td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td50 defd"><div class="cel">Analgesic, Opioid receptor agonist, Noradrenaline reuptake inhibitor</div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Disease</span></th> <td class="td51 repd"><div class="cel">Diabetic peripheral neuropathy (DPN) [DS:<a href="/entry/H01459">H01459</a>]</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td50 defd"><div class="cel">OPRM1 [HSA:<a href="/entry/hsa:4988">4988</a>] [KO:<a href="/entry/K04215">K04215</a>]<br>SLC6A2 (NAT1) [HSA:<a href="/entry/hsa:6530">6530</a>] [KO:<a href="/entry/K05035">K05035</a>]</div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td51 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04080+4988">hsa04080</a> </span></td><td>Neuroactive ligand-receptor interaction</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04721+6530">hsa04721</a> </span></td><td>Synaptic vesicle cycle</td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Metabolism</span></th> <td class="td50 defd"><div class="cel">Enzyme: UGT [KO:<a href="/entry/K00699">K00699</a>]<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td51 defd"><div class="cel"><button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D10199';return false;">DDI search</button></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td50 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D10199">br08303</a>]<br> N NERVOUS SYSTEM<br> N02 ANALGESICS<br> N02A OPIOIDS<br> N02AX Other opioids<br> N02AX06 Tapentadol<br> D10199 Tapentadol hydrochloride (JAN) <JP/US><br> USP drug classification [BR:<a href="/brite/br08302+D10199">br08302</a>]<br> Analgesics<br> Opioid Analgesics, Long-acting<br> Tapentadol<br> D10199 Tapentadol hydrochloride (JAN)<br> Opioid Analgesics, Short-acting<br> Tapentadol<br> D10199 Tapentadol hydrochloride (JAN)<br> Therapeutic category of drugs in Japan [BR:<a href="/brite/br08301+D10199">br08301</a>]<br> 8 Narcotics<br> 82 Non-alkaloidal narcotics<br> 821 Synthetic narcotics<br> 8219 Others<br> D10199 Tapentadol hydrochloride (JAN)<br> Drug groups [BR:<a href="/brite/br08330+D10199+DG01564">br08330</a>]<br> Neuropsychiatric agent<br> DG01564 Opioid receptor agonist<br> DG01563 mu-Opioid receptor agonist<br> DG00826 Tapentadol<br> D10199 Tapentadol hydrochloride<br> Analgesic<br> DG01984 Opioid analgesics<br> DG00826 Tapentadol<br> D10199 Tapentadol hydrochloride<br> Metabolizing enzyme substrate<br> DG02924 UGT substrate<br> DG00826 Tapentadol<br> D10199 Tapentadol hydrochloride<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D10199">br08310</a>]<br> G Protein-coupled receptors<br> Rhodopsin family<br> Opioid<br> OPRM1<br> D10199 Tapentadol hydrochloride (JAN) <US><br> Transporters<br> Solute carrier family<br> SLC6<br> SLC6A2 (NAT1)<br> D10199 Tapentadol hydrochloride (JAN) <US><br> New drug approvals in the USA [<a href="/kegg/drug/br08319.html?id=D10199">br08319.html</a>]<br> New molecular entities and new therapeutic biological products<br> D10199<br> New drug approvals in Japan [<a href="/kegg/drug/br08318.html?id=D10199">br08318.html</a>]<br> Drugs with new active ingredients<br> D10199<br> New drug approvals in the USA, Europe and Japan [<a href="/kegg/drug/br08328.html?id=D10199">br08328.html</a>]<br> Approval dates by FDA, EMA and PMDA<br> D10199<br> Drug metabolizing enzymes and transporters [<a href="/kegg/drug/br08309.html?id=D10199">br08309.html</a>]<br> Drug metabolizing enzymes<br> D10199<br> Drug groups [BR:<a href="/brite/br08330+D10199+DG01564">br08330</a>]<br> Neuropsychiatric agent<br> DG01564 Opioid receptor agonist<br> DG01563 mu-Opioid receptor agonist<br> DG00826 Tapentadol<br> Analgesic<br> DG01984 Opioid analgesics<br> DG00826 Tapentadol<br> Metabolizing enzyme substrate<br> DG02924 UGT substrate<br> DG00826 Tapentadol<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D10199';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>175591-09-0</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=163312232">163312232</a></td></tr></table></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D10199';return false;">All DBs</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td51 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 17<br> 1 C8y C 17.4300 -17.0800<br> 2 C8x C 17.4300 -18.4800<br> 3 C8x C 18.6200 -19.1800<br> 4 C8x C 19.8800 -18.4800<br> 5 C8y C 19.8800 -17.0800<br> 6 C8x C 18.6200 -16.3800<br> 7 O1a O 16.1700 -16.3800<br> 8 C1c C 21.0700 -16.3800<br> 9 C1c C 22.2600 -17.0800<br> 10 C1b C 21.0700 -14.9800<br> 11 C1b C 23.4500 -16.3800<br> 12 C1a C 22.2600 -14.2800<br> 13 N1c N 24.6400 -17.0800<br> 14 C1a C 22.2600 -18.4800<br> 15 C1a C 25.9000 -16.3800<br> 16 C1a C 24.6400 -18.4800<br> 17 X Cl 29.3300 -18.6200<br> BOND 16<br> 1 1 2 2<br> 2 2 3 1<br> 3 3 4 2<br> 4 4 5 1<br> 5 5 6 2<br> 6 1 6 1<br> 7 1 7 1<br> 8 5 8 1<br> 9 8 9 1<br> 10 8 10 1 #Down<br> 11 9 11 1<br> 12 10 12 1<br> 13 11 13 1<br> 14 9 14 1 #Down<br> 15 13 15 1<br> 16 13 16 1<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D10199">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>