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genetics</title> <meta name="description" content="Search results for: genetics"> <meta name="keywords" content="genetics"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="genetics"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 144</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: genetics</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">144</span> Genetics, Law and Society: Regulating New Genetic Technologies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aisling%20De%20Paor">Aisling De Paor</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Scientific and technological developments are driving genetics and genetic technologies into the public sphere. Scientists are making genetic discoveries as to the make up of the human body and the cause and effect of disease, diversity and disability amongst individuals. Technological innovation in the field of genetics is also advancing, with the development of genetic testing, and other emerging genetic technologies, including gene editing (which offers the potential for genetic modification). In addition to the benefits for medicine, health care and humanity, these genetic advances raise a range of ethical, legal and societal concerns. From an ethical perspective, such advances may, for example, change the concept of humans and what it means to be human. Science may take over in conceptualising human beings, which may push the boundaries of existing human rights. New genetic technologies, particularly gene editing techniques create the potential to stigmatise disability, by highlighting disability or genetic difference as something that should be eliminated or anticipated. From a disability perspective, use (and misuse) of genetic technologies raise concerns about discrimination and violations to the dignity and integrity of the individual. With an acknowledgement of the likely future orientation of genetic science, and in consideration of the intersection of genetics and disability, this paper highlights the main concerns raised as genetic science and technology advances (particularly with gene editing developments), and the consequences for disability and human rights. Through the use of traditional doctrinal legal methodologies, it investigates the use (and potential misuse) of gene editing as creating the potential for a unique form of discrimination and stigmatization to develop, as well as a potential gateway to a form of new, subtle eugenics. This article highlights the need to maintain caution as to the use, application and the consequences of genetic technologies. With a focus on the law and policy position in Europe, it examines the need to control and regulate these new technologies, particularly gene editing. In addition to considering the need for regulation, this paper highlights non-normative approaches to address this area, including awareness raising and education, public discussion and engagement with key stakeholders in the field and the development of a multifaceted genetics advisory network. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=disability" title="disability">disability</a>, <a href="https://publications.waset.org/abstracts/search?q=gene-editing" title=" gene-editing"> gene-editing</a>, <a href="https://publications.waset.org/abstracts/search?q=genetics" title=" genetics"> genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=law" title=" law"> law</a>, <a href="https://publications.waset.org/abstracts/search?q=regulation" title=" regulation"> regulation</a> </p> <a href="https://publications.waset.org/abstracts/66469/genetics-law-and-society-regulating-new-genetic-technologies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66469.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">143</span> Theoretical Approaches to Graphic and Formal Generation from Evolutionary Genetics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Luz%20Estrada">Luz Estrada</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The currents of evolutionary materialistic thought have argued that knowledge about an object is not obtained through the abstractive method. That is, the object cannot come to be understood if founded upon itself, nor does it take place by the encounter between form and matter. According to this affirmation, the research presented here identified as a problematic situation the absence of comprehension of the formal creation as a generative operation. This has been referred to as a recurrent lack in the production of objects and corresponds to the need to conceive the configurative process from the reality of its genesis. In this case, it is of interest to explore ways of creation that consider the object as if it were a living organism, as well as responding to the object’s experience as embodied in the designer since it unfolds its genesis simultaneously to the ways of existence of those who are involved in the generative experience. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=architecture" title="architecture">architecture</a>, <a href="https://publications.waset.org/abstracts/search?q=theoretical%20graphics" title=" theoretical graphics"> theoretical graphics</a>, <a href="https://publications.waset.org/abstracts/search?q=evolutionary%20genetics" title=" evolutionary genetics"> evolutionary genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=formal%20perception" title=" formal perception"> formal perception</a> </p> <a href="https://publications.waset.org/abstracts/158586/theoretical-approaches-to-graphic-and-formal-generation-from-evolutionary-genetics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158586.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">117</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">142</span> A Set of Microsatellite Markers for Population Genetics of Copper-Winged Bat (Myotis rufoniger) Using Saliva DNA</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Junghwa%20An">Junghwa An</a>, <a href="https://publications.waset.org/abstracts/search?q=Sungkyoung%20Choi"> Sungkyoung Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Eun%20Ye"> Eun Ye</a>, <a href="https://publications.waset.org/abstracts/search?q=San%20Hoon%20Han"> San Hoon Han</a>, <a href="https://publications.waset.org/abstracts/search?q=Young-Gun%20Choi"> Young-Gun Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chul%20Oun%20Jung"> Chul Oun Jung</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The copper-winged bat (Myotis rufoniger) is the widely distributed medium body-sized bat in Asia, including Korea. This bat population has been decreasing because of habitat loss. This study reported the isolation and characterization of ten polymorphic microsatellite loci in endangered M. rufoniger. To do genetic studies, we use saliva DNA of bats during winter sleep period. The number of alleles per locus ranged from 2 to 9, and the observed and expected heterozygosities ranged from 0.063 to 0.750 and from 0.063 to 0.865, respectively. The average polymorphic information content (PIC) value of these markers was 0.37. Two loci of M. rufoniger showed departure from Hardy-Weinberg equilibrium(HWE). This demonstrated that the ten microsatellite loci can be used as genetic markers for further investigation of the copper-winged bat. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=copper-winged%20bat" title="copper-winged bat">copper-winged bat</a>, <a href="https://publications.waset.org/abstracts/search?q=microsatellite" title=" microsatellite"> microsatellite</a>, <a href="https://publications.waset.org/abstracts/search?q=population%20genetics" title=" population genetics"> population genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=South%20Korea" title=" South Korea"> South Korea</a> </p> <a href="https://publications.waset.org/abstracts/46642/a-set-of-microsatellite-markers-for-population-genetics-of-copper-winged-bat-myotis-rufoniger-using-saliva-dna" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46642.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">373</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">141</span> Chromosomes Are Present in a Fixed Region on the Equatorial Plate Within the Interphase of Cell Division</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chunxiao%20Wu">Chunxiao Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Dongyun%20Jiang"> Dongyun Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Tao%20Jiang"> Tao Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Luxia%20Xu"> Luxia Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Qian%20Xu"> Qian Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Meng%20Zhao"> Meng Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Qin%20Zhu"> Qin Zhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhigang%20Guo"> Zhigang Guo</a>, <a href="https://publications.waset.org/abstracts/search?q=Jinlan%20Pan"> Jinlan Pan</a>, <a href="https://publications.waset.org/abstracts/search?q=Suning%20Chen"> Suning Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The stability and evolution of human genetics depends on chromosomes (and chromosome-chromosome interactions). We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relationship between chromosome-chromosome interactions and to further investigate the role of chromosomes and their impact on cell biological behavior. In this study, we explored the relative spatial positional relationships of chromosomes [t (9;22) and t (15;17)] in B-ALL cells by using the three-dimensions DNA in situ fluorescent hybridization (3D-FISH) method. The results showed that chromosomes [t (9;22) and t (15;17)] showed relatively stable spatial relationships. The relative stability of the spatial location of chromosomes in dividing cells may be relevant to disease. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chromosome" title="chromosome">chromosome</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20genetics" title=" human genetics"> human genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=chromosome%20territory" title=" chromosome territory"> chromosome territory</a>, <a href="https://publications.waset.org/abstracts/search?q=3D-FISH" title=" 3D-FISH"> 3D-FISH</a> </p> <a href="https://publications.waset.org/abstracts/188219/chromosomes-are-present-in-a-fixed-region-on-the-equatorial-plate-within-the-interphase-of-cell-division" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188219.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">47</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">140</span> SciPaaS: a Scientific Execution Platform for the Cloud</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wesley%20H.%20Brewer">Wesley H. Brewer</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20C.%20Sanford"> John C. Sanford</a> </p> <p class="card-text"><strong>Abstract:</strong></p> SciPaaS is a prototype development of an execution platform/middleware designed to make it easy for scientists to rapidly deploy their scientific applications (apps) to the cloud. It provides all the necessary infrastructure for running typical IXP (Input-eXecute-Plot) style apps, including: a web interface, post-processing and plotting capabilities, job scheduling, real-time monitoring of running jobs, and even a file/case manager. In this paper, first the system architecture is described and then is demonstrated for a two scientific applications: (1) a simple finite-difference solver of the inviscid Burger’s equation, and (2) Mendel’s Accountant—a forward-time population genetics simulation model. The implications of the prototype are discussed in terms of ease-of-use and deployment options, especially in cloud environments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=web-based%20simulation" title="web-based simulation">web-based simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=cloud%20computing" title=" cloud computing"> cloud computing</a>, <a href="https://publications.waset.org/abstracts/search?q=Platform-as-a-Service%20%28PaaS%29" title=" Platform-as-a-Service (PaaS)"> Platform-as-a-Service (PaaS)</a>, <a href="https://publications.waset.org/abstracts/search?q=rapid%20application%20development%20%28RAD%29" title=" rapid application development (RAD)"> rapid application development (RAD)</a>, <a href="https://publications.waset.org/abstracts/search?q=population%20genetics" title=" population genetics"> population genetics</a> </p> <a href="https://publications.waset.org/abstracts/20920/scipaas-a-scientific-execution-platform-for-the-cloud" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20920.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">590</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">139</span> Microarrays: Wide Clinical Utilities and Advances in Healthcare</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salma%20M.%20Wakil">Salma M. Wakil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Advances in the field of genetics overwhelmed detecting large number of inherited disorders at the molecular level and directed to the development of innovative technologies. These innovations have led to gene sequencing, prenatal mutation detection, pre-implantation genetic diagnosis; population based carrier screening and genome wide analyses using microarrays. Microarrays are widely used in establishing clinical and diagnostic setup for genetic anomalies at a massive level, with the advent of cytoscan molecular karyotyping as a clinical utility card for detecting chromosomal aberrations with high coverage across the entire human genome. Unlike a regular karyotype that relies on the microscopic inspection of chromosomes, molecular karyotyping with cytoscan constructs virtual chromosomes based on the copy number analysis of DNA which improves its resolution by 100-fold. We have been investigating a large number of patients with Developmental Delay and Intellectual disability with this platform for establishing micro syndrome deletions and have detected number of novel CNV’s in the Arabian population with the clinical relevance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microarrays" title="microarrays">microarrays</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20karyotyping" title=" molecular karyotyping"> molecular karyotyping</a>, <a href="https://publications.waset.org/abstracts/search?q=developmental%20delay" title=" developmental delay"> developmental delay</a>, <a href="https://publications.waset.org/abstracts/search?q=genetics" title=" genetics"> genetics</a> </p> <a href="https://publications.waset.org/abstracts/24137/microarrays-wide-clinical-utilities-and-advances-in-healthcare" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24137.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">458</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">138</span> Investigating Associations Between Genes Linked to Social Behavior and Early Covid-19 Spread Using Multivariate Linear Regression Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gwenyth%20C.%20Eichfeld">Gwenyth C. Eichfeld</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Variation in global COVID-19 spread is partly explained by social and behavioral factors. Many of these behaviors are linked to genetics. The short polymorphism of the 5-HTTLPR promoter region of the SLC6A4 gene is linked to collectivism. The seven-repeat polymorphism of the DRD4 gene is linked to risk-taking, migration, sensation-seeking, and impulsivity. Fewer CAG repeats in the androgen receptor gene are linked to impulsivity. This study investigates an association between the country-level frequency of these variants and early Covid-19 spread. Results of regression analysis indicate a significant association between increased country-wide prevalence of the short allele of the SLC6A4 gene and decreased COVID-19 spread when other factors that have been linked to COVID-19 are controlled for. Additionally, results show that the short allele of the SLC6A4 gene is associated with COVID-19 spread through GDP and percent urbanization rather than collectivism. Results showed no significant association between the frequency of the DRD4 polymorphism nor the androgen receptor polymorphism with early COVID-19 spread. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neuroscience" title="neuroscience">neuroscience</a>, <a href="https://publications.waset.org/abstracts/search?q=genetics" title=" genetics"> genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=population%20sciences" title=" population sciences"> population sciences</a>, <a href="https://publications.waset.org/abstracts/search?q=Covid-19" title=" Covid-19"> Covid-19</a> </p> <a href="https://publications.waset.org/abstracts/188475/investigating-associations-between-genes-linked-to-social-behavior-and-early-covid-19-spread-using-multivariate-linear-regression-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188475.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">36</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">137</span> Exploring Gaming-Learning Interaction in MMOG Using Data Mining Methods</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meng-Tzu%20Cheng">Meng-Tzu Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Louisa%20Rosenheck"> Louisa Rosenheck</a>, <a href="https://publications.waset.org/abstracts/search?q=Chen-Yen%20Lin"> Chen-Yen Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Eric%20Klopfer"> Eric Klopfer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of the research is to explore some of the ways in which gameplay data can be analyzed to yield results that feedback into the learning ecosystem. Back-end data for all users as they played an MMOG, The Radix Endeavor, was collected, and this study reports the analyses on a specific genetics quest by using the data mining techniques, including the decision tree method. In the study, different reasons for quest failure between participants who eventually succeeded and who never succeeded were revealed. Regarding the in-game tools use, trait examiner was a key tool in the quest completion process. Subsequently, the results of decision tree showed that a lack of trait examiner usage can be made up with additional Punnett square uses, displaying multiple pathways to success in this quest. The methods of analysis used in this study and the resulting usage patterns indicate some useful ways that gameplay data can provide insights in two main areas. The first is for game designers to know how players are interacting with and learning from their game. The second is for players themselves as well as their teachers to get information on how they are progressing through the game, and to provide help they may need based on strategies and misconceptions identified in the data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MMOG" title="MMOG">MMOG</a>, <a href="https://publications.waset.org/abstracts/search?q=decision%20tree" title=" decision tree"> decision tree</a>, <a href="https://publications.waset.org/abstracts/search?q=genetics" title=" genetics"> genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=gaming-learning%20interaction" title=" gaming-learning interaction"> gaming-learning interaction</a> </p> <a href="https://publications.waset.org/abstracts/58320/exploring-gaming-learning-interaction-in-mmog-using-data-mining-methods" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58320.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">136</span> Identifying Environmental Adaptive Genetic Loci in Caloteropis Procera (Estabragh): Population Genetics and Landscape Genetic Analyses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Sheidaei">Masoud Sheidaei</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad-Reza%20Kordasti"> Mohammad-Reza Kordasti</a>, <a href="https://publications.waset.org/abstracts/search?q=Fahimeh%20Koohdar"> Fahimeh Koohdar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Calotropis procera (Aiton) W.T.Aiton, (Apocynaceae), is an economically and medicinally important plant species which is an evergreen, perennial shrub growing in arid and semi-arid climates, and can tolerate very low annual rainfall (150 mm) and a dry season. The plant can also tolerate temperature ran off 20 to30°C and is not frost tolerant. This plant species prefers free-draining sandy soils but can grow also in alkaline and saline soils.It is found at a range of altitudes from exposed coastal sites to medium elevations up to 1300 m. Due to morpho-physiological adaptations of C. procera and its ability to tolerate various abiotic stresses. This taxa can compete with desirable pasture species and forms dense thickets that interfere with stock management, particularly mustering activities. Caloteropis procera grows only in southern part of Iran where in comprises a limited number of geographical populations. We used different population genetics and r landscape analysis to produce data on geographical populations of C. procera based on molecular genetic study using SCoT molecular markers. First, we used spatial principal components (sPCA), as it can analyze data in a reduced space and can be used for co-dominant markers as well as presence / absence data as is the case in SCoT molecular markers. This method also carries out Moran I and Mantel tests to reveal spatial autocorrelation and test for the occurrence of Isolation by distance (IBD). We also performed Random Forest analysis to identify the importance of spatial and geographical variables on genetic diversity. Moreover, we used both RDA (Redundency analysis), and LFMM (Latent factor mixed model), to identify the genetic loci significantly associated with geographical variables. A niche modellng analysis was carried our to predict present potential area for distribution of these plants and also the area present by the year 2050. The results obtained will be discussed in this paper. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=population%20genetics" title="population genetics">population genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=landscape%20genetic" title=" landscape genetic"> landscape genetic</a>, <a href="https://publications.waset.org/abstracts/search?q=Calotreropis%20procera" title=" Calotreropis procera"> Calotreropis procera</a>, <a href="https://publications.waset.org/abstracts/search?q=niche%20modeling" title=" niche modeling"> niche modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=SCoT%20markers" title=" SCoT markers"> SCoT markers</a> </p> <a href="https://publications.waset.org/abstracts/164970/identifying-environmental-adaptive-genetic-loci-in-caloteropis-procera-estabragh-population-genetics-and-landscape-genetic-analyses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164970.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">93</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">135</span> The Genetic Basis of the Lack of Impulse Control: What is Provided for the Criminal Law?</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amir%20Bastani">Amir Bastani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The result of the research in the field of human behavioural genetics demonstrates a genetic contribution of behavioural differences in aggression, violence, drug and substance abuse, antisocial personality disorder and other related traits. As the field of human behavioural genetics progresses and achieves credibility, the criminal accused continue to use its types of evidence into the criminal law. One of the most important genetic factors which controls certain neurotransmitters like dopamine and serotonin is the Monoamine Oxidase Acid A (MAOA) gene, known as the 'warrior gene'. The high-profile study by Caspi and colleagues in 2002 showed that the combination between one type of variation of the MAOA gene and childhood maltreatment noticeably predisposes a person to antisocial behaviour. Moreover, further scientific research shows that individuals with the MAOA gene have to some degree difficulties in controlling their impulses. Based on the evidence of MAOA, some criminal accused claimed difficulties in self-control. In the first case – the famous case of Mobley – the court rejected the MAOA evidence on the ground of the lack of scientific support. In contrast, in other cases after the Mobley trial, courts accepted the evidence of MAOA. In this paper, the issue of lack of impulse control produced by the MAOA gene and cases which relied on the MAOA evidence and successfully being accepted will be reviewed in detail. Finally, the anticipation of the paper for the future use of the MAOA evidence in criminal cases will be presented. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=genetic%20defence" title="genetic defence">genetic defence</a>, <a href="https://publications.waset.org/abstracts/search?q=criminal%20responsibility" title=" criminal responsibility"> criminal responsibility</a>, <a href="https://publications.waset.org/abstracts/search?q=MAOA" title=" MAOA"> MAOA</a>, <a href="https://publications.waset.org/abstracts/search?q=self-control" title=" self-control"> self-control</a> </p> <a href="https://publications.waset.org/abstracts/20503/the-genetic-basis-of-the-lack-of-impulse-control-what-is-provided-for-the-criminal-law" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20503.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">472</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">134</span> Advancing Our Understanding of Age-Related Changes in Executive Functions: Insights from Neuroimaging, Genetics and Cognitive Neurosciences</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yasaman%20Mohammadi">Yasaman Mohammadi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Executive functions are a critical component of goal-directed behavior, encompassing a diverse set of cognitive processes such as working memory, cognitive flexibility, and inhibitory control. These functions are known to decline with age, but the precise mechanisms underlying this decline remain unclear. This paper provides an in-depth review of recent research investigating age-related changes in executive functions, drawing on insights from neuroimaging, genetics, and cognitive neuroscience. Through an interdisciplinary approach, this paper offers a nuanced understanding of the complex interplay between neural mechanisms, genetic factors, and cognitive processes that contribute to executive function decline in aging. Here, we investigate how different neuroimaging methods, like functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), have helped scientists better understand the brain bases for age-related declines in executive function. Additionally, we discuss the role of genetic factors in mediating individual differences in executive functions across the lifespan, as well as the potential for cognitive interventions to mitigate age-related decline. Overall, this paper presents a comprehensive and integrative view of the current state of knowledge regarding age-related changes in executive functions. It underscores the need for continued interdisciplinary research to fully understand the complex and dynamic nature of executive function decline in aging, with the ultimate goal of developing effective interventions to promote healthy cognitive aging. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=executive%20functions" title="executive functions">executive functions</a>, <a href="https://publications.waset.org/abstracts/search?q=aging" title=" aging"> aging</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroimaging" title=" neuroimaging"> neuroimaging</a>, <a href="https://publications.waset.org/abstracts/search?q=cognitive%20neuroscience" title=" cognitive neuroscience"> cognitive neuroscience</a>, <a href="https://publications.waset.org/abstracts/search?q=working%20memory" title=" working memory"> working memory</a>, <a href="https://publications.waset.org/abstracts/search?q=cognitive%20training" title=" cognitive training"> cognitive training</a> </p> <a href="https://publications.waset.org/abstracts/166514/advancing-our-understanding-of-age-related-changes-in-executive-functions-insights-from-neuroimaging-genetics-and-cognitive-neurosciences" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166514.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">67</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">133</span> Inherited Eye Diseases in Africa: A Scoping Review and Strategy for an African Longitudinal Eye Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bawa%20Yusuf%20Muhammad">Bawa Yusuf Muhammad</a>, <a href="https://publications.waset.org/abstracts/search?q=Musa%20Abubakar%20Kana"> Musa Abubakar Kana</a>, <a href="https://publications.waset.org/abstracts/search?q=Aminatu%20Abdulrahman"> Aminatu Abdulrahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Kerry%20Goetz"> Kerry Goetz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Inherited eye diseases are disorders that affect globally, 1 in 1000 people. The six main world populations have created databases containing information on eye genotypes. Aim: The aim of the scoping review was to mine and present the available information to date on the genetics of inherited eye diseases within the African continent. Method: Literature Search Strategy was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed and Google Scholar searched for articles on inherited eye diseases from inception to 20th June 2022. Both Original and review articles that report on inherited, genetic or developmental/congenital eye diseases within the African Continent were included in the research. Results: A total of 1162 citations were obtained, but only 37 articles were reviewed based on the inclusion and exclusion criteria. The highest output of publications on inherited eye diseases comes from South Africa and Tunisia (about 43%), followed by Morocco and Egypt (27%), then Sub-Saharan Africa and North Africa (13.50%), while the remaining articles (16.5%) originated from Nigeria, Ghana, Mauritania Cameroon, Zimbabwe and combined article between Zimbabwe and Cameroon. Glaucoma and inherited retinal disorders represent the most studied diseases, followed by Albinism and congenital cataracts, respectively. Conclusion: Despite the growing research from Tunisia, Morocco, Egypt and South Africa, Sub-Saharan Africa remains almost a virgin region to explore the genetics of eye diseases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=inherited%20eye%20diseases" title="inherited eye diseases">inherited eye diseases</a>, <a href="https://publications.waset.org/abstracts/search?q=Africa" title=" Africa"> Africa</a>, <a href="https://publications.waset.org/abstracts/search?q=scoping%20review" title=" scoping review"> scoping review</a>, <a href="https://publications.waset.org/abstracts/search?q=longitudinal%20eye%20study" title=" longitudinal eye study"> longitudinal eye study</a> </p> <a href="https://publications.waset.org/abstracts/184310/inherited-eye-diseases-in-africa-a-scoping-review-and-strategy-for-an-african-longitudinal-eye-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184310.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">57</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">132</span> Bioinformatic Approaches in Population Genetics and Phylogenetic Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Sheidai">Masoud Sheidai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biologists with a special field of population genetics and phylogeny have different research tasks such as populations’ genetic variability and divergence, species relatedness, the evolution of genetic and morphological characters, and identification of DNA SNPs with adaptive potential. To tackle these problems and reach a concise conclusion, they must use the proper and efficient statistical and bioinformatic methods as well as suitable genetic and morphological characteristics. In recent years application of different bioinformatic and statistical methods, which are based on various well-documented assumptions, are the proper analytical tools in the hands of researchers. The species delineation is usually carried out with the use of different clustering methods like K-means clustering based on proper distance measures according to the studied features of organisms. A well-defined species are assumed to be separated from the other taxa by molecular barcodes. The species relationships are studied by using molecular markers, which are analyzed by different analytical methods like multidimensional scaling (MDS) and principal coordinate analysis (PCoA). The species population structuring and genetic divergence are usually investigated by PCoA and PCA methods and a network diagram. These are based on bootstrapping of data. The Association of different genes and DNA sequences to ecological and geographical variables is determined by LFMM (Latent factor mixed model) and redundancy analysis (RDA), which are based on Bayesian and distance methods. Molecular and morphological differentiating characters in the studied species may be identified by linear discriminant analysis (DA) and discriminant analysis of principal components (DAPC). We shall illustrate these methods and related conclusions by giving examples from different edible and medicinal plant species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=GWAS%20analysis" title="GWAS analysis">GWAS analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=K-Means%20clustering" title=" K-Means clustering"> K-Means clustering</a>, <a href="https://publications.waset.org/abstracts/search?q=LFMM" title=" LFMM"> LFMM</a>, <a href="https://publications.waset.org/abstracts/search?q=multidimensional%20scaling" title=" multidimensional scaling"> multidimensional scaling</a>, <a href="https://publications.waset.org/abstracts/search?q=redundancy%20analysis" title=" redundancy analysis"> redundancy analysis</a> </p> <a href="https://publications.waset.org/abstracts/149154/bioinformatic-approaches-in-population-genetics-and-phylogenetic-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149154.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">124</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">131</span> ACTN3 R577X Polymorphism in Romany Children from Eastern Slovakia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jarmila%20Bernasovska">Jarmila Bernasovska</a>, <a href="https://publications.waset.org/abstracts/search?q=Pavel%20Ru%C5%BEbarsk%C3%BD"> Pavel Ružbarský</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivan%20Bernasovsky"> Ivan Bernasovsky</a>, <a href="https://publications.waset.org/abstracts/search?q=Regina%20Lohajov%C3%A1%20Behulov%C3%A1"> Regina Lohajová Behulová</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The paper presents the results of the application of molecular genetics methods in sport research, with special emphasis on the most advanced methods and trends in diagnosing of motoric predispositions for the sake of identifying talented children. Genetic tests differ in principle from the traditional motoric tests, because the DNA of an individual does not change during life. Genetics is important in determining the capacity of an individual and for professional sport level. Genetic information can be used for individual genetic predispositions in early childhood. The phenotypes are influenced by a combination of genetic and environmental factors. The aim of the presented study was to examine physical condition, coordination skills, motoric docility and to determine the frequency of ACTN3 (R577X) gene in Romany children from Eastern Slovakia and compared their motoric performance with non-Romany children. This paper is not looking just for a performance, but also its association to genetic predispositions in relation to ACTN3 gene and its R577X polymorphism. Genotype data were obtained from 175 Romany children from 6 to 15 years old and 218 non-Romany children at the same age from Eastern Slovakia. Biological material for genetic analyses comprised samples of buccal swabs. Genotypes were determined using Real Time High resolution melting PCR method (Rotor Gene 6000 Corbett and LightCycler 480 Roche). Romany children of analyzed group legged to non-Romany children at the same age in all the compared tests. The % distribution of R and X alleles in children was different from controls. The frequency of XX genotype was 11,45% which is comparable to a frequency of an Indian population. Data were analysed with the ANOVA statistical programme and parametric and nonparametric tests. This work was supported by grants APVV-0716-10, ITMS 26220120023 and ITMS 26220120041. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ACTN3%20gene" title="ACTN3 gene">ACTN3 gene</a>, <a href="https://publications.waset.org/abstracts/search?q=R577X%20polymorphism" title=" R577X polymorphism"> R577X polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=Romany%20children" title=" Romany children"> Romany children</a>, <a href="https://publications.waset.org/abstracts/search?q=sport%20performance" title=" sport performance"> sport performance</a>, <a href="https://publications.waset.org/abstracts/search?q=Slovakia" title=" Slovakia"> Slovakia</a> </p> <a href="https://publications.waset.org/abstracts/13208/actn3-r577x-polymorphism-in-romany-children-from-eastern-slovakia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13208.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">457</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">130</span> TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Boro%C5%88ov%C3%A1">I. Boroňová</a>, <a href="https://publications.waset.org/abstracts/search?q=J.Bernasovsk%C3%A1"> J.Bernasovská</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20K%C4%BEoc"> J. Kľoc</a>, <a href="https://publications.waset.org/abstracts/search?q=Z.%20Tomkov%C3%A1"> Z. Tomková</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Petrej%C4%8D%C3%ADkov%C3%A1"> E. Petrejčíková</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Gabrikov%C3%A1"> D. Gabriková</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Ma%C4%8Dekov%C3%A1"> S. Mačeková </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoporosis is a complex health disease characterized by low bone mineral density, which is determined by an interaction of genetics with metabolic and environmental factors. Current research in genetics of osteoporosis is focused on identification of responsible genes and polymorphisms. TNFRSF11B gene plays a key role in bone remodeling. The aim of this study was to investigate the genotype and allele distribution of A163G (rs3102735) osteoprotegerin gene promoter and G1181C (rs2073618) osteoprotegerin first exon polymorphisms in the group of 180 unrelated postmenopausal women with diagnosed osteoporosis and 180 normal controls. Genomic DNA was isolated from peripheral blood leukocytes using standard methodology. Genotyping for presence of different polymorphisms was performed using the Custom Taqman®SNP Genotyping assays. Hardy-Weinberg equilibrium was tested for each SNP in the groups of participants using the chi-square (χ2) test. The distribution of investigated genotypes in the group of patients with osteoporosis were as follows: AA (66.7%), AG (32.2%), GG (1.1%) for A163G polymorphism; GG (19.4%), CG (44.4%), CC (36.1%) for G1181C polymorphism. The distribution of genotypes in normal controls were follows: AA (71.1%), AG (26.1%), GG (2.8%) for A163G polymorphism; GG (22.2%), CG (48.9%), CC (28.9%) for G1181C polymorphism. In A163G polymorphism the variant G allele was more common among patients with osteoporosis: 17.2% versus 15.8% in normal controls. Also, in G1181C polymorphism the phenomenon of more frequent occurrence of C allele in the group of patients with osteoporosis was observed (58.3% versus 53.3%). Genotype and allele distributions showed no significant differences (A163G: χ2=0.270, p=0.605; χ2=0.250, p=0.616; G1181C: χ2= 1.730, p=0.188; χ2=1.820, p=0.177). Our results represents an initial study, further studies of more numerous file and associations studies will be carried out. Knowing the distribution of genotypes is important for assessing the impact of these polymorphisms on various parameters associated with osteoporosis. Screening for identification of “at-risk” women likely to develop osteoporosis and initiating subsequent early intervention appears to be most effective strategy to substantially reduce the risks of osteoporosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=osteoporosis" title="osteoporosis">osteoporosis</a>, <a href="https://publications.waset.org/abstracts/search?q=real-time%20PCR%20method" title=" real-time PCR method"> real-time PCR method</a>, <a href="https://publications.waset.org/abstracts/search?q=SNP%20polymorphisms" title=" SNP polymorphisms"> SNP polymorphisms</a> </p> <a href="https://publications.waset.org/abstracts/1283/tnfrsf11b-gene-polymorphisms-a163g-and-g11811c-in-prediction-of-osteoporosis-risk" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1283.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">129</span> Development of a Software System for Management and Genetic Analysis of Biological Samples for Forensic Laboratories</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mariana%20Lima">Mariana Lima</a>, <a href="https://publications.waset.org/abstracts/search?q=Rodrigo%20Silva"> Rodrigo Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Victor%20Stange"> Victor Stange</a>, <a href="https://publications.waset.org/abstracts/search?q=Teodiano%20Bastos"> Teodiano Bastos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to the high reliability reached by DNA tests, since the 1980s this kind of test has allowed the identification of a growing number of criminal cases, including old cases that were unsolved, now having a chance to be solved with this technology. Currently, the use of genetic profiling databases is a typical method to increase the scope of genetic comparison. Forensic laboratories must process, analyze, and generate genetic profiles of a growing number of samples, which require time and great storage capacity. Therefore, it is essential to develop methodologies capable to organize and minimize the spent time for both biological sample processing and analysis of genetic profiles, using software tools. Thus, the present work aims the development of a software system solution for laboratories of forensics genetics, which allows sample, criminal case and local database management, minimizing the time spent in the workflow and helps to compare genetic profiles. For the development of this software system, all data related to the storage and processing of samples, workflows and requirements that incorporate the system have been considered. The system uses the following software languages: HTML, CSS, and JavaScript in Web technology, with NodeJS platform as server, which has great efficiency in the input and output of data. In addition, the data are stored in a relational database (MySQL), which is free, allowing a better acceptance for users. The software system here developed allows more agility to the workflow and analysis of samples, contributing to the rapid insertion of the genetic profiles in the national database and to increase resolution of crimes. The next step of this research is its validation, in order to operate in accordance with current Brazilian national legislation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=database" title="database">database</a>, <a href="https://publications.waset.org/abstracts/search?q=forensic%20genetics" title=" forensic genetics"> forensic genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20analysis" title=" genetic analysis"> genetic analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=sample%20management" title=" sample management"> sample management</a>, <a href="https://publications.waset.org/abstracts/search?q=software%20solution" title=" software solution"> software solution</a> </p> <a href="https://publications.waset.org/abstracts/63474/development-of-a-software-system-for-management-and-genetic-analysis-of-biological-samples-for-forensic-laboratories" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63474.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">370</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">128</span> Applying EzRAD Method for SNPs Discovery in Population Genetics of Freshwater and Marine Fish in the South of Vietnam</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Quyen%20Vu%20Dang%20Ha">Quyen Vu Dang Ha</a>, <a href="https://publications.waset.org/abstracts/search?q=Oanh%20Truong%20Thi"> Oanh Truong Thi</a>, <a href="https://publications.waset.org/abstracts/search?q=Thuoc%20Tran%20Linh"> Thuoc Tran Linh</a>, <a href="https://publications.waset.org/abstracts/search?q=Kent%20Carpenter"> Kent Carpenter</a>, <a href="https://publications.waset.org/abstracts/search?q=Thinh%20Doan%20Vu"> Thinh Doan Vu</a>, <a href="https://publications.waset.org/abstracts/search?q=Binh%20Dang%20Thuy"> Binh Dang Thuy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Enzyme restriction site associated DNA (EzRAD) has recently emerged as a promising genomic approach for exploring fish genetic diversity on a genome-wide scale. This is a simplified method for genomic genotyping in non-model organisms and applied for SNPs discovery in the population genetics of freshwater and marine fish in the South of Vietnam. The observations of regional-scale differentiation of commercial freshwater fish (smallscale croakers Boesemania microlepis) and marine fish (emperor Lethrinus lentjan) are clarified. Samples were collected along Hau River and coastal area in the south and center Vietnam. 52 DNA samples from Tra Vinh, An Giang Province for Boesemania microlepis and 34 DNA samples of Lethrinus lentjan from Phu Quoc, Nha Trang, Da Nang Province were used to prepare EzRAD libraries from genomic DNA digested with MboI and Sau3AI. A pooled sample of regional EzRAD libraries was sequenced using the HiSeq 2500 Illumina platform. For Boesemania microlepis, the small scale population different from upstream to downstream of Hau river were detected, An Giang population exhibited less genetic diversity (SNPs per individual from 14 to 926), in comparison to Tra Vinh population (from 11 to 2172). For Lethrinus lentjan, the result showed the minor difference between populations in the Northern and the Southern Mekong River. The numbers of contigs and SNPs vary from 1315 to 2455 and from 7122 to 8594, respectively (P ≤ 0.01). The current preliminary study reveals regional scale population disconnection probably reflecting environmental changing. Additional sampling and EzRad libraries need to be implemented for resource management in the Mekong Delta. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Boesemania%20microlepis" title="Boesemania microlepis">Boesemania microlepis</a>, <a href="https://publications.waset.org/abstracts/search?q=EzRAD" title=" EzRAD"> EzRAD</a>, <a href="https://publications.waset.org/abstracts/search?q=Lethrinus%20lentjan" title=" Lethrinus lentjan"> Lethrinus lentjan</a>, <a href="https://publications.waset.org/abstracts/search?q=SNPs" title=" SNPs"> SNPs</a> </p> <a href="https://publications.waset.org/abstracts/33607/applying-ezrad-method-for-snps-discovery-in-population-genetics-of-freshwater-and-marine-fish-in-the-south-of-vietnam" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33607.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">509</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">127</span> The Effects of Fungicide and Genetics on Fungal Diseases on Wheat in Nebraska With Emphasis on Stem Rust</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Javed%20Sidiqi">Javed Sidiqi</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephen%20Baezinger"> Stephen Baezinger</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephen%20Wegulo"> Stephen Wegulo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wheat (Triticum aestivum L.) production continues to be challenged by foliar fungal diseases although significant improvement has been made to manage the diseases through developing resistant varieties and the fungicide use to ensure sufficient wheat is produced to meet the growing population’s need. Significant crop losses have been recorded in the history of grain production and yield losses due to fungal diseases, and the trend continues to threat food security in the world and particularly in the less developed countries. The impact of individual fungal diseases on grain yield has been studied extensively to determine crop losses. However, there is limited research available to find out the combined effects of fungal diseases on grain yield and the ways to effectively manage the diseases. Therefore, the objectives of this research were to study the effect of fungal pathogens on grain yield of pre-released winter wheat genotypes in fungicide treated and untreated plots, and to determine whether S7b gene was present in ‘Gage’ wheat as previously hypothesized. Sixty winter wheat genotypes in fungicide treated and untreated plots were studied across four environments. There was a significant effect of fungicide on grain yield consistently across four environments in three years. Fungicide treated wheat lines demonstrated (4,496 kg/ ha-1) grain yield compared to (3,147 kg/ ha-1) grain yield in untreated wheat lines indicating 43% increased grain yield due to severity of foliar fungal diseases. Furthermore, fungicide application also caused an increase in protein concentration from 153 (g kg-1) to 164 (g kg-1) in treated plots in along with test weight from 73 to 77 (kg hL-1) respectively. Gage wheat variety and ISr7b-Ra were crossed to determine presence of Sr7b in Gage. The F2 and F2:3 segregating families were screened and evaluated for stem rust resistance. The segregation of families fell within 15:1 ratio for two separate resistance genes suggesting that Sr7b segregates independently from an unknown resistance gene in Gage that needs to be characterized for its use in the future wheat breeding program to develop resistant wheat varieties. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=funicide" title="funicide">funicide</a>, <a href="https://publications.waset.org/abstracts/search?q=genetics" title=" genetics"> genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=foliar%20diseases" title=" foliar diseases"> foliar diseases</a>, <a href="https://publications.waset.org/abstracts/search?q=grain" title=" grain"> grain</a> </p> <a href="https://publications.waset.org/abstracts/149205/the-effects-of-fungicide-and-genetics-on-fungal-diseases-on-wheat-in-nebraska-with-emphasis-on-stem-rust" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149205.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">126</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">126</span> Against the Philosophical-Scientific Racial Project of Biologizing Race</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anthony%20F.%20Peressini">Anthony F. Peressini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The concept of race has recently come prominently back into discussion in the context of medicine and medical science, along with renewed effort to biologize racial concepts. This paper argues that this renewed effort to biologize race by way of medicine and population genetics fail on their own terms, and more importantly, that the philosophical project of biologizing race ought to be recognized for what it is—a retrograde racial project—and abandoned. There is clear agreement that standard racial categories and concepts cannot be grounded in the old way of racial naturalism, which understand race as a real, interest-independent biological/metaphysical category in which its members share “physical, moral, intellectual, and cultural characteristics.” But equally clear is the very real and pervasive presence of racial concepts in individual and collective consciousness and behavior, and so it remains a pressing area in which to seek deeper understanding. Recent philosophical work has endeavored to reconcile these two observations by developing a “thin” conception of race, grounded in scientific concepts but without the moral and metaphysical content. Such “thin,” science-based analyses take the “commonsense” or “folk” sense of race as it functions in contemporary society as the starting point for their philosophic-scientific projects to biologize racial concepts. A “philosophic-scientific analysis” is a special case of the cornerstone of analytic philosophy: a conceptual analysis. That is, a rendering of a concept into the more perspicuous concepts that constitute it. Thus a philosophic-scientific account of a concept is an attempt to work out an analysis of a concept that makes use of empirical science's insights to ground, legitimate and explicate the target concept in terms of clearer concepts informed by empirical results. The focus in this paper is on three recent philosophic-scientific cases for retaining “race” that all share this general analytic schema, but that make use of “medical necessity,” population genetics, and human genetic clustering, respectively. After arguing that each of these three approaches suffers from internal difficulties, the paper considers the general analytic schema employed by such biologizations of race. While such endeavors are inevitably prefaced with the disclaimer that the theory to follow is non-essentialist and non-racialist, the case will be made that such efforts are not neutral scientific or philosophical projects but rather are what sociologists call a racial project, that is, one of many competing efforts that conjoin a representation of what race means to specific efforts to determine social and institutional arrangements of power, resources, authority, etc. Accordingly, philosophic-scientific biologizations of race, since they begin from and condition their analyses on “folk” conceptions, cannot pretend to be “prior to” other disciplinary insights, nor to transcend the social-political dynamics involved in formulating theories of race. As a result, such traditional philosophical efforts can be seen to be disciplinarily parochial and to address only a caricature of a large and important human problem—and thereby further contributing to the unfortunate isolation of philosophical thinking about race from other disciplines. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=population%20genetics" title="population genetics">population genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=ontology%20of%20race" title=" ontology of race"> ontology of race</a>, <a href="https://publications.waset.org/abstracts/search?q=race-based%20medicine" title=" race-based medicine"> race-based medicine</a>, <a href="https://publications.waset.org/abstracts/search?q=racial%20formation%20theory" title=" racial formation theory"> racial formation theory</a>, <a href="https://publications.waset.org/abstracts/search?q=racial%20projects" title=" racial projects"> racial projects</a>, <a href="https://publications.waset.org/abstracts/search?q=racism" title=" racism"> racism</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20construction" title=" social construction"> social construction</a> </p> <a href="https://publications.waset.org/abstracts/68502/against-the-philosophical-scientific-racial-project-of-biologizing-race" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68502.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">125</span> Habitat Suitability, Genetic Diversity and Population Structure of Two Sympatric Fruit Bat Species Reveal the Need of an Urgent Conservation Action</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Thani%20Ibouroi">Mohamed Thani Ibouroi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Cheha"> Ali Cheha</a>, <a href="https://publications.waset.org/abstracts/search?q=Claudine%20Montgelard"> Claudine Montgelard</a>, <a href="https://publications.waset.org/abstracts/search?q=Veronique%20Arnal"> Veronique Arnal</a>, <a href="https://publications.waset.org/abstracts/search?q=Dawiyat%20Massoudi"> Dawiyat Massoudi</a>, <a href="https://publications.waset.org/abstracts/search?q=Guillelme%20Astruc"> Guillelme Astruc</a>, <a href="https://publications.waset.org/abstracts/search?q=Said%20Ali%20Ousseni%20Dhurham"> Said Ali Ousseni Dhurham</a>, <a href="https://publications.waset.org/abstracts/search?q=Aurelien%20Besnard"> Aurelien Besnard</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Livingstone's flying fox (Pteropus livingstonii) and the Comorian fruit bat (P.seychellensis comorensis) are two endemic fruit bat species among the mostly threatened animals of the Comoros archipelagos. Despite their role as important ecosystem service providers like all flying fox species as pollinators and seed dispersers, little is known about their ecologies, population genetics and structures making difficult the development of evidence-based conservation strategies. In this study, we assess spatial distribution and ecological niche of both species using Species Distribution Modeling (SDM) based on the recent Ensemble of Small Models (ESMs) approach using presence-only data. Population structure and genetic diversity of the two species were assessed using both mitochondrial and microsatellite markers based on non-invasive genetic samples. Our ESMs highlight a clear niche partitioning of the two sympatric species. Livingstone’s flying fox has a very limited distribution, restricted on steep slope of natural forests at high elevation. On the contrary, the Comorian fruit bat has a relatively large geographic range spread over low elevations in farmlands and villages. Our genetic analysis shows a low genetic diversity for both fruit bats species. They also show that the Livingstone’s flying fox population of the two islands were genetically isolated while no evidence of genetic differentiation was detected for the Comorian fruit bats between islands. Our results support the idea that natural habitat loss, especially the natural forest loss and fragmentation are the important factors impacting the distribution of the Livingstone’s flying fox by limiting its foraging area and reducing its potential roosting sites. On the contrary, the Comorian fruit bats seem to be favored by human activities probably because its diets are less specialized. By this study, we concluded that the Livingstone’s flying fox species and its habitat are of high priority in term of conservation at the Comoros archipelagos scale. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Comoros%20islands" title="Comoros islands">Comoros islands</a>, <a href="https://publications.waset.org/abstracts/search?q=ecological%20niche" title=" ecological niche"> ecological niche</a>, <a href="https://publications.waset.org/abstracts/search?q=habitat%20loss" title=" habitat loss"> habitat loss</a>, <a href="https://publications.waset.org/abstracts/search?q=population%20genetics" title=" population genetics"> population genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=fruit%20bats" title=" fruit bats"> fruit bats</a>, <a href="https://publications.waset.org/abstracts/search?q=conservation%20biology" title=" conservation biology"> conservation biology</a> </p> <a href="https://publications.waset.org/abstracts/62161/habitat-suitability-genetic-diversity-and-population-structure-of-two-sympatric-fruit-bat-species-reveal-the-need-of-an-urgent-conservation-action" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62161.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">267</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">124</span> The Maps of Meaning (MoM) Consciousness Theory</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Scott%20Andersen">Scott Andersen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Perhaps simply and rather unadornedly, consciousness is having multiple goals for action and the continuously adjudication of such goals to implement action, referred to as the Maps of Meaning (MoM) Consciousness Theory. The MoM theory triangulates through three parallel corollaries, action (behavior), mechanism (morphology/pathophysiology), and goals (teleology). (1) An organism’s consciousness contains a fluid, nested goals. These goals are not intentionality, but intersectionality, embodiment meeting the world. i.e., Darwinian inclusive fitness or randomization, then survival of the fittest. These goals form via gradual descent under inclusive fitness, the goals being the abstraction of a ‘match’ between the evolutionary environment and organism. Human consciousness implements the brain efficiency hypothesis, genetics, epigenetics, and experience crystallize efficiencies, not necessitating best or objective but fitness, i.e., perceived efficiency based on one’s adaptive environment. These efficiencies are objectively arbitrary, but determine the operation and level of one’s consciousness, termed extreme thrownness. Since inclusive fitness drives efficiencies in physiologic mechanism, morphology and behavior (action) and originates one’s goals, embodiment is necessarily entangled to human consciousness as its the intersection of mechanism or action (both necessitating embodiment) occurring in the world that determines fitness. Perception is the operant process of consciousness and is the consciousness’ de facto goal adjudication process. Goal operationalization is fundamentally efficiency-based via one’s unique neuronal mapping as a byproduct of genetics, epigenetics, and experience. Perception involves information intake and information discrimination, equally underpinned by efficiencies of inclusive fitness via extreme thrownness. Perception isn’t a ‘frame rate,’ but Bayesian priors of efficiency based on one’s extreme thrownness. Consciousness and human consciousness is a modular (i.e., a scalar level of richness, which builds up like building blocks) and dimensionalized (i.e., cognitive abilities become possibilities as emergent phenomena at various modularities, like stratified factors in factor analysis). The meta dimensions of human consciousness seemingly include intelligence quotient, personality (five-factor model), richness of perception intake, and richness of perception discrimination, among other potentialities. Future consciousness research should utilize factor analysis to parse modularities and dimensions of human consciousness and animal models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=consciousness" title="consciousness">consciousness</a>, <a href="https://publications.waset.org/abstracts/search?q=perception" title=" perception"> perception</a>, <a href="https://publications.waset.org/abstracts/search?q=prospection" title=" prospection"> prospection</a>, <a href="https://publications.waset.org/abstracts/search?q=embodiment" title=" embodiment"> embodiment</a> </p> <a href="https://publications.waset.org/abstracts/184886/the-maps-of-meaning-mom-consciousness-theory" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184886.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">59</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">123</span> Antigen Stasis can Predispose Primary Ciliary Dyskinesia (PCD) Patients to Asthma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nadzeya%20Marozkina">Nadzeya Marozkina</a>, <a href="https://publications.waset.org/abstracts/search?q=Joe%20Zein"> Joe Zein</a>, <a href="https://publications.waset.org/abstracts/search?q=Benjamin%20Gaston"> Benjamin Gaston</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: We have observed that many patients with Primary Ciliary Dyskinesia (PCD) benefit from asthma medications. In healthy airways, the ciliary function is normal. Antigens and irritants are rapidly cleared, and NO enters the gas phase normally to be exhaled. In the PCD airways, however, antigens, such as Dermatophagoides, are not as well cleared. This defect leads to oxidative stress, marked by increased DUOX1 expression and decreased superoxide dismutase [SOD] activity (manuscript under revision). H₂O₂, in high concentrations in the PCD airway, injures the airway. NO is oxidized rather than being exhaled, forming cytotoxic peroxynitrous acid. Thus, antigen stasis on PCD airway epithelium leads to airway injury and may predispose PCD patients to asthma. Indeed, recent population genetics suggest that PCD genes may be associated with asthma. We therefore hypothesized that PCD patients would be predisposed to having asthma. Methods. We analyzed our database of 18 million individual electronic medical records (EMRs) in the Indiana Network for Patient Care research database (INPCR). There is not an ICD10 code for PCD itself; code Q34.8 is most commonly used clinically. To validate analysis of this code, we queried patients who had an ICD10 code for both bronchiectasis and situs inversus totalis in INPCR. We also studied a validation cohort using the IBM Explorys® database (over 80 million individuals). Analyses were adjusted for age, sex and race using a 1 PCD: 3 controls matching method in INPCR and multivariable logistic regression in the IBM Explorys® database. Results. The prevalence of asthma ICD10 codes in subjects with a code Q34.8 was 67% vs 19% in controls (P < 0.0001) (Regenstrief Institute). Similarly, in IBM*Explorys, the OR [95% CI] for having asthma if a patient also had ICD10 code 34.8, relative to controls, was =4.04 [3.99; 4.09]. For situs inversus alone the OR [95% CI] was 4.42 [4.14; 4.71]; and bronchiectasis alone the OR [95% CI] =10.68 (10.56; 10.79). For both bronchiectasis and situs inversus together, the OR [95% CI] =28.80 (23.17; 35.81). Conclusions: PCD causes antigen stasis in the human airway (under review), likely predisposing to asthma in addition to oxidative and nitrosative stress and to airway injury. Here, we show that, by several different population-based metrics, and using two large databases, patients with PCD appear to have between a three- and 28-fold increased risk of having asthma. These data suggest that additional studies should be undertaken to understand the role of ciliary dysfunction in the pathogenesis and genetics of asthma. Decreased antigen clearance caused by ciliary dysfunction may be a risk factor for asthma development. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antigen" title="antigen">antigen</a>, <a href="https://publications.waset.org/abstracts/search?q=PCD" title=" PCD"> PCD</a>, <a href="https://publications.waset.org/abstracts/search?q=asthma" title=" asthma"> asthma</a>, <a href="https://publications.waset.org/abstracts/search?q=nitric%20oxide" title=" nitric oxide"> nitric oxide</a> </p> <a href="https://publications.waset.org/abstracts/157907/antigen-stasis-can-predispose-primary-ciliary-dyskinesia-pcd-patients-to-asthma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/157907.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">107</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">122</span> Frequent Pattern Mining for Digenic Human Traits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atsuko%20Okazaki">Atsuko Okazaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Jurg%20Ott"> Jurg Ott</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Some genetic diseases (‘digenic traits’) are due to the interaction between two DNA variants. For example, certain forms of Retinitis Pigmentosa (a genetic form of blindness) occur in the presence of two mutant variants, one in the ROM1 gene and one in the RDS gene, while the occurrence of only one of these mutant variants leads to a completely normal phenotype. Detecting such digenic traits by genetic methods is difficult. A common approach to finding disease-causing variants is to compare 100,000s of variants between individuals with a trait (cases) and those without the trait (controls). Such genome-wide association studies (GWASs) have been very successful but hinge on genetic effects of single variants, that is, there should be a difference in allele or genotype frequencies between cases and controls at a disease-causing variant. Frequent pattern mining (FPM) methods offer an avenue at detecting digenic traits even in the absence of single-variant effects. The idea is to enumerate pairs of genotypes (genotype patterns) with each of the two genotypes originating from different variants that may be located at very different genomic positions. What is needed is for genotype patterns to be significantly more common in cases than in controls. Let Y = 2 refer to cases and Y = 1 to controls, with X denoting a specific genotype pattern. We are seeking association rules, ‘X → Y’, with high confidence, P(Y = 2|X), significantly higher than the proportion of cases, P(Y = 2) in the study. Clearly, generally available FPM methods are very suitable for detecting disease-associated genotype patterns. We use fpgrowth as the basic FPM algorithm and built a framework around it to enumerate high-frequency digenic genotype patterns and to evaluate their statistical significance by permutation analysis. Application to a published dataset on opioid dependence furnished results that could not be found with classical GWAS methodology. There were 143 cases and 153 healthy controls, each genotyped for 82 variants in eight genes of the opioid system. The aim was to find out whether any of these variants were disease-associated. The single-variant analysis did not lead to significant results. Application of our FPM implementation resulted in one significant (p < 0.01) genotype pattern with both genotypes in the pattern being heterozygous and originating from two variants on different chromosomes. This pattern occurred in 14 cases and none of the controls. Thus, the pattern seems quite specific to this form of substance abuse and is also rather predictive of disease. An algorithm called Multifactor Dimension Reduction (MDR) was developed some 20 years ago and has been in use in human genetics ever since. This and our algorithms share some similar properties, but they are also very different in other respects. The main difference seems to be that our algorithm focuses on patterns of genotypes while the main object of inference in MDR is the 3 × 3 table of genotypes at two variants. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=digenic%20traits" title="digenic traits">digenic traits</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20variants" title=" DNA variants"> DNA variants</a>, <a href="https://publications.waset.org/abstracts/search?q=epistasis" title=" epistasis"> epistasis</a>, <a href="https://publications.waset.org/abstracts/search?q=statistical%20genetics" title=" statistical genetics"> statistical genetics</a> </p> <a href="https://publications.waset.org/abstracts/135746/frequent-pattern-mining-for-digenic-human-traits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">121</span> Analytical Validity Of A Tech Transfer Solution To Internalize Genetic Testing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lesley%20Northrop">Lesley Northrop</a>, <a href="https://publications.waset.org/abstracts/search?q=Justin%20DeGrazia"> Justin DeGrazia</a>, <a href="https://publications.waset.org/abstracts/search?q=Jessica%20Greenwood"> Jessica Greenwood</a> </p> <p class="card-text"><strong>Abstract:</strong></p> ASPIRA Labs now offers an en-suit and ready-to-implement technology transfer solution to enable labs and hospitals that lack the resources to build it themselves to offer in-house genetic testing. This unique platform employs a patented Molecular Inversion Probe (MIP) technology that combines the specificity of a hybrid capture protocol with the ease of an amplicon-based protocol and utilizes an advanced bioinformatics analysis pipeline based on machine learning. To demonstrate its efficacy, two independent genetic tests were validated on this technology transfer platform: expanded carrier screening (ECS) and hereditary cancer testing (HC). The analytical performance of ECS and HC was validated separately in a blinded manner for calling three different types of variants: SNVs, short indels (typically, <50 bp), and large indels/CNVs defined as multi-exonic del/dup events. The reference set was constructed using samples from Coriell Institute, an external clinical genetic testing laboratory, Maine Molecular Quality Controls Inc. (MMQCI), SeraCare and GIAB Consortium. Overall, the analytical performance showed a sensitivity and specificity of >99.4% for both ECS and HC in detecting SNVs. For indels, both tests reported specificity of 100%, and ECS demonstrated a sensitivity of 100%, whereas HC exhibited a sensitivity of 96.5%. The bioinformatics pipeline also correctly called all reference CNV events resulting in a sensitivity of 100% for both tests. No additional calls were made in the HC panel, leading to a perfect performance (specificity and F-measure of 100%). In the carrier panel, however, three additional positive calls were made outside the reference set. Two of these calls were confirmed using an orthogonal method and were re-classified as true positives leaving only one false positive. The pipeline also correctly identified all challenging carrier statuses, such as positive cases for spinal muscular atrophy and alpha-thalassemia, resulting in 100% sensitivity. After confirmation of additional positive calls via long-range PCR and MLPA, specificity for such cases was estimated at 99%. These performance metrics demonstrate that this tech-transfer solution can be confidently internalized by clinical labs and hospitals to offer mainstream ECS and HC as part of their test catalog, substantially increasing access to quality germline genetic testing for labs of all sizes and resources levels. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=clinical%20genetics" title="clinical genetics">clinical genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20testing" title=" genetic testing"> genetic testing</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20genetics" title=" molecular genetics"> molecular genetics</a>, <a href="https://publications.waset.org/abstracts/search?q=technology%20transfer" title=" technology transfer"> technology transfer</a> </p> <a href="https://publications.waset.org/abstracts/139070/analytical-validity-of-a-tech-transfer-solution-to-internalize-genetic-testing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139070.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">178</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">120</span> Innate Immunity of Insects in Brief</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ehsan%20Soleymaninejadian">Ehsan Soleymaninejadian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> As the field of immunology is growing day by day, and its chaotic system amazes more people, greed of research in this area is growing; however dealing with human or mammalian cells such as mice make the research expensive. Although there are some differences between higher animals with insects, importance of innate immunity during evolution made it untouched. So, for understanding the innate immunity insects can be good models. They are cheap; reproduction is fast and in the case genetics, less complicated. In this review, we tried to briefly tackle with important factors in insects’ innate immunity such as melanization, encapsulation, JAK-STAT, IMD, and Toll pathways. At the end, we explained how hormones and nerve system also can impact on immune system and make it more beautiful. In concluding remarks, the possibility of taking help from insect immune system to fight against diseases such as cancer has been considered. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=insects" title="insects">insects</a>, <a href="https://publications.waset.org/abstracts/search?q=innate%20immunity" title=" innate immunity"> innate immunity</a>, <a href="https://publications.waset.org/abstracts/search?q=melanization" title=" melanization"> melanization</a>, <a href="https://publications.waset.org/abstracts/search?q=intracellular%20pathways" title=" intracellular pathways"> intracellular pathways</a>, <a href="https://publications.waset.org/abstracts/search?q=hormones" title=" hormones"> hormones</a> </p> <a href="https://publications.waset.org/abstracts/74600/innate-immunity-of-insects-in-brief" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74600.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">226</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">119</span> Different Roles for Mentors and Mentees in an e-Learning Environment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nidhi%20Gadura">Nidhi Gadura</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Given the increase in the number of students and administrators asking for online courses the author developed two partially online courses. One was a biology majors at genetics course while the other was a non-majors at biology course. The student body at Queensborough Community College is generally underprepared and has work and family obligations. As an educator, one has to be mindful about changing the pedagogical approach, therefore, special care was taken when designing the course material. Despite the initial concerns, both of these partially online courses were received really well by students. Lessons learnt were that student engagement is the key to success in an online course. Good practices to run a successful online course for underprepared students are discussed in this paper. Also discussed are the lessons learnt for making the eLearning environment better for all the students in the class, overachievers and underachievers alike. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=partially%20online%20course" title="partially online course">partially online course</a>, <a href="https://publications.waset.org/abstracts/search?q=pedagogy" title=" pedagogy"> pedagogy</a>, <a href="https://publications.waset.org/abstracts/search?q=student%20engagement" title=" student engagement"> student engagement</a>, <a href="https://publications.waset.org/abstracts/search?q=community%20college" title=" community college"> community college</a> </p> <a href="https://publications.waset.org/abstracts/48193/different-roles-for-mentors-and-mentees-in-an-e-learning-environment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48193.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">118</span> The Creation of a Yeast Model for 5-oxoproline Accumulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pratiksha%20Dubey">Pratiksha Dubey</a>, <a href="https://publications.waset.org/abstracts/search?q=Praveen%20Singh"> Praveen Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Shantanu%20Sen%20Gupta"> Shantanu Sen Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Anand%20K.%20Bachhawat"> Anand K. Bachhawat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> 5-oxoproline (pyroglutamic acid) is a cyclic lactam of glutamic acid. In the cell, it can be produced by several different pathways and is metabolized into glutamate with the help of the 5-oxoprolinase enzyme (OPLAH or OXP1). The inhibition of 5-oxoprolinase enzyme in mammals was found to result in heart failure and is thought to be a consequence of oxidative stress [1]. To analyze the consequences of 5-oxoproline accumulation more clearly, we are generating models for 5-oxoproline accumulation in yeast. The 5-oxoproline accumulation model in yeast is being developed by two different strategies. The first one is by overexpression of the mouse  -glutamylcyclotransferase enzyme. It degrades -glu-met dipeptide into 5-oxoproline and methionine taken by the cell from the medium. The second strategy is by providing high concentration of 5-oxoproline externally to the yeast cells. The intracellular 5-oxoproline levels in both models are being evaluated. In addition, the metabolic and cellular consequences are being investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=5-oxoproline" title="5-oxoproline">5-oxoproline</a>, <a href="https://publications.waset.org/abstracts/search?q=pyroglutamic%20acid" title=" pyroglutamic acid"> pyroglutamic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=yeast" title=" yeast"> yeast</a>, <a href="https://publications.waset.org/abstracts/search?q=genetics" title=" genetics"> genetics</a> </p> <a href="https://publications.waset.org/abstracts/171881/the-creation-of-a-yeast-model-for-5-oxoproline-accumulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171881.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">87</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">117</span> Genetic Analysis of Iron, Phosphorus, Potassium and Zinc Concentration in Peanut</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ajay%20B.%20C.">Ajay B. C.</a>, <a href="https://publications.waset.org/abstracts/search?q=Meena%20H.%20N."> Meena H. N.</a>, <a href="https://publications.waset.org/abstracts/search?q=Dagla%20M.%20C."> Dagla M. C.</a>, <a href="https://publications.waset.org/abstracts/search?q=Narendra%20Kumar"> Narendra Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Makwana%20%20A.%20D."> Makwana A. D.</a>, <a href="https://publications.waset.org/abstracts/search?q=Bera%20S.%20K."> Bera S. K.</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalariya%20K.%20A."> Kalariya K. A.</a>, <a href="https://publications.waset.org/abstracts/search?q=Singh%20A.%20L."> Singh A. L.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The high-energy value, protein content and minerals makes peanut a rich source of nutrition at comparatively low cost. Basic information on genetics and inheritance of these mineral elements is very scarce. Hence, in the present study inheritance (using additive-dominance model) and association of mineral elements was studied in two peanut crosses. Dominance variance (H) played an important role in the inheritance of P, K, Fe and Zn in peanut pods. Average degree of dominance for most of the traits was greater than unity indicating over dominance for these traits. Significant associations were also observed among mineral elements both in F2 and F3 generations but pod yield had no associations with mineral elements (with few exceptions). Di-allele/bi-parental mating could be followed to identify high yielding and mineral dense segregates. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=correlation" title="correlation">correlation</a>, <a href="https://publications.waset.org/abstracts/search?q=dominance%20variance" title=" dominance variance"> dominance variance</a>, <a href="https://publications.waset.org/abstracts/search?q=mineral%20elements" title=" mineral elements"> mineral elements</a>, <a href="https://publications.waset.org/abstracts/search?q=peanut" title=" peanut"> peanut</a> </p> <a href="https://publications.waset.org/abstracts/14731/genetic-analysis-of-iron-phosphorus-potassium-and-zinc-concentration-in-peanut" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14731.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">413</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">116</span> Autism Spectrum Disorder Interventions, Problems and Solutions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ammara%20Jabeen">Ammara Jabeen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This survey report aims to find the interventions and their effectiveness that are being used globally as well as in Pakistan to treat autistic kids. ‘Autism spectrum disorder (ASD) is a state associated with brain development that shows ‘how a person perceives and socializes with others, causing problems in social interaction and communication’. Besides these problems, these children suffer from restricted and repetitive behaviors too. The term ‘Spectrum’ in Autism Spectrum Disorder refers to the wide range of symptoms and severity. The main cause of this Autism Spectrum Disorder is not known yet, but the research showed that genetics and environmental factors play important roles. In this survey report, after a literature review, some of the possible solutions are suggested based on the most common problems that these children are currently facing in their daily lives. Based on this report, we are able to overcome the lack of the resources (e.g. language, cost, training etc.) that mostly exist in Pakistani culture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autism" title="autism">autism</a>, <a href="https://publications.waset.org/abstracts/search?q=interventions" title=" interventions"> interventions</a>, <a href="https://publications.waset.org/abstracts/search?q=spectrum" title=" spectrum"> spectrum</a>, <a href="https://publications.waset.org/abstracts/search?q=disorder" title=" disorder"> disorder</a> </p> <a href="https://publications.waset.org/abstracts/192186/autism-spectrum-disorder-interventions-problems-and-solutions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192186.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">22</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">115</span> Blood Flow in Stenosed Arteries: Analytical and Numerical Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shashi%20Sharma">Shashi Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Uaday%20Singh"> Uaday Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20K.%20Katiyar"> V. K. Katiyar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Blood flow through a stenosed tube, which is of great interest to mechanical engineers as well as medical researchers. If stenosis exists in an artery, normal blood flow is disturbed. The deposition of fatty substances, cholesterol, cellular waste products in the inner lining of an artery results to plaque formation .The present study deals with a mathematical model for blood flow in constricted arteries. Blood is considered as a Newtonian, incompressible, unsteady and laminar fluid flowing in a cylindrical rigid tube along the axial direction. A time varying pressure gradient is applied in the axial direction. An analytical solution is obtained using the numerical inversion method for Laplace Transform for calculating the velocity profile of fluid as well as particles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blood%20flow" title="blood flow">blood flow</a>, <a href="https://publications.waset.org/abstracts/search?q=stenosis" title=" stenosis"> stenosis</a>, <a href="https://publications.waset.org/abstracts/search?q=Newtonian%20fluid" title=" Newtonian fluid"> Newtonian fluid</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20biology%20and%20genetics" title=" medical biology and genetics"> medical biology and genetics</a> </p> <a href="https://publications.waset.org/abstracts/25427/blood-flow-in-stenosed-arteries-analytical-and-numerical-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25427.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">516</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=genetics&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=genetics&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=genetics&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=genetics&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=genetics&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div 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