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tabindex="1"> </div> </form>   </div> </div> </nav> </div> </div> </div>    </header>   <section class="main-content" role="main"> <div class="container"> <div class="row">  <div class="left-contentbox col-12 col-md-7 col-lg-8"> <div class="main-page-title"> <h1>Topics</h1>  </div> <div class="row featured-list"> </div>  <div class="row numerictext-list"> <div class="col-6 col-md-4"><div class="text-thumb"><h1>A</h1><ul><li><a href="https://www.psychiatrist.com/addiction/">Addiction</a></li><li><a href="https://www.psychiatrist.com/adherence/">Adherence</a></li><li><a href="https://www.psychiatrist.com/alzheimers/">Alzheimer Disease</a></li><li><a href="https://www.psychiatrist.com/anxiety/">Anxiety</a></li><li><a href="https://www.psychiatrist.com/anxiolytics/">Anxiolytics</a></li><li><a href="https://www.psychiatrist.com/assessment/">Assessment Methods</a></li><li><a href="https://www.psychiatrist.com/adhd/">Attention-Deficit/Hyperactivity Disorder</a></li><li><a href="https://www.psychiatrist.com/autism/">Autism Spectrum Disorders</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>B</h1><ul><li><a href="https://www.psychiatrist.com/bipolar-disorder/">Bipolar Disorder</a></li><li><a href="https://www.psychiatrist.com/body-dysmorphic-disorder/">Body Dysmorphic Disorder</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>C</h1><ul><li><a href="https://www.psychiatrist.com/oncology/">Cancer</a></li><li><a href="https://www.psychiatrist.com/cardiology/">Cardiology</a></li><li><a href="https://www.psychiatrist.com/catatonia/">Catatonia</a></li><li><a href="https://www.psychiatrist.com/pediatric-psychiatry/">Child and Adolescent Psychiatry</a></li><li><a href="https://www.psychiatrist.com/cognition/">Cognition</a></li><li><a href="https://www.psychiatrist.com/comorbidity/">Comorbidity</a></li><li><a href="https://www.psychiatrist.com/alternative-medicine/">Complementary and Alternative Medicine</a></li><li><a href="https://www.psychiatrist.com/healthcare-economics/">Cost and Economics</a></li><li><a href="https://www.psychiatrist.com/covid/">COVID</a></li><li><a href="https://www.psychiatrist.com/cultural/">Cross-Cultural Psychiatry</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>D</h1><ul><li><a href="https://www.psychiatrist.com/delirium/">Delirium</a></li><li><a href="https://www.psychiatrist.com/dementia/">Dementia</a></li><li><a href="https://www.psychiatrist.com/depression/">Depression (MDD)</a></li><li><a href="https://www.psychiatrist.com/dermatology/">Dermatology</a></li><li><a href="https://www.psychiatrist.com/diagnostic-tools/">Diagnostic Tools</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>E</h1><ul><li><a href="https://www.psychiatrist.com/eating-disorders/">Eating Disorders</a></li><li><a href="https://www.psychiatrist.com/education/">Education</a></li><li><a href="https://www.psychiatrist.com/ect/">Electroconvulsive Therapy</a></li><li><a href="https://www.psychiatrist.com/emergency-medicine/">Emergency</a></li><li><a href="https://www.psychiatrist.com/encephalitis/">Encephalitis</a></li><li><a href="https://www.psychiatrist.com/palliative/">End-of-Life and Palliative Care</a></li><li><a href="https://www.psychiatrist.com/epilepsy/">Epilepsy</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>F</h1><ul><li><a href="https://www.psychiatrist.com/factitious-disorder/">Factitious Disorder</a></li><li><a href="https://www.psychiatrist.com/fibromyalgia/">Fibromyalgia</a></li><li><a href="https://www.psychiatrist.com/forensic/">Forensics</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>G</h1><ul><li><a href="https://www.psychiatrist.com/gastroenterology/">Gastroenterology</a></li><li><a href="https://www.psychiatrist.com/genetics/">Genetics</a></li><li><a href="https://www.psychiatrist.com/geriatrics/">Geriatric</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>H</h1><ul><li><a href="https://www.psychiatrist.com/headache/">Headache</a></li><li><a href="https://www.psychiatrist.com/hepatitis/">Hepatitis</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>I</h1><ul><li><a href="https://www.psychiatrist.com/impulse-control/">Impulse-Control Disorders</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>J</h1><ul><li><a href="https://www.psychiatrist.com/journal/">Journal</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>L</h1><ul><li><a href="https://www.psychiatrist.com/lgbtqia/">LGBTQ</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>M</h1><ul><li><a href="https://www.psychiatrist.com/medical/">Medical</a></li><li><a href="https://www.psychiatrist.com/medical-conditions/">Medical Conditions</a></li><li><a href="https://www.psychiatrist.com/metabolic-disorders/">Metabolic Disorders</a></li><li><a href="https://www.psychiatrist.com/migraine/">Migraine</a></li><li><a href="https://www.psychiatrist.com/mood-disorders/">Mood Disorders</a></li><li><a href="https://www.psychiatrist.com/movement-disorders/">Movement Disorders</a></li><li><a href="https://www.psychiatrist.com/ms/">Multiple Sclerosis</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>N</h1><ul><li><a href="https://www.psychiatrist.com/neurodevelopmental/">Neurodevelopmental</a></li><li><a href="https://www.psychiatrist.com/neuroimaging/">Neuroimaging</a></li><li><a href="https://www.psychiatrist.com/nms/">Neuroleptic Malignant Syndrome</a></li><li><a href="https://www.psychiatrist.com/neurology/">Neurology</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>O</h1><ul><li><a href="https://www.psychiatrist.com/ocd/">Obsessive-Compulsive and Related Disorders</a></li><li><a href="https://www.psychiatrist.com/other-mental-disorders/">Other Mental Disorders</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>P</h1><ul><li><a href="https://www.psychiatrist.com/pain/">Pain</a></li><li><a href="https://www.psychiatrist.com/panic-disorder/">Panic Disorder</a></li><li><a href="https://www.psychiatrist.com/parkinsons/">Parkinson Disease</a></li><li><a href="https://www.psychiatrist.com/patient-care/">Patient Care</a></li><li><a href="https://www.psychiatrist.com/personality-disorders/">Personality Disorders</a></li><li><a href="https://www.psychiatrist.com/phobic-disorders/">Phobic Disorders</a></li><li><a href="https://www.psychiatrist.com/mental/">Populations</a></li><li><a href="https://www.psychiatrist.com/ptsd/">Posttraumatic Stress Disorder</a></li><li><a href="https://www.psychiatrist.com/pmdd/">Premenstrual Dysphoric Disorder</a></li><li><a href="https://www.psychiatrist.com/primary-care/">Primary Care</a></li><li><a href="https://www.psychiatrist.com/psychiatry/">Psychiatry</a></li><li><a href="https://www.psychiatrist.com/psychopharmacology/">Psychopharmacology</a></li><li><a href="https://www.psychiatrist.com/psychotherapy/">Psychotherapy</a></li><li><a href="https://www.psychiatrist.com/psychotic-disorders/">Psychotic Disorders</a></li><li><a href="https://www.psychiatrist.com/pulmonology/">Pulmonary Disease</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>R</h1><ul><li><a href="https://www.psychiatrist.com/rare-disease/">Rare Diseases</a></li><li><a href="https://www.psychiatrist.com/renal-disease/">Renal Disease</a></li><li><a href="https://www.psychiatrist.com/research-methods/">Research Methods and Statistics</a></li><li><a href="https://www.psychiatrist.com/rheumatology/">Rheumatology</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>S</h1><ul><li><a href="https://www.psychiatrist.com/schizophrenia/">Schizophrenia/Schizoaffective Disorders</a></li><li><a href="https://www.psychiatrist.com/seasonal-affective-disorders/">Seasonal Affective Disorder</a></li><li><a href="https://www.psychiatrist.com/seizures/">Seizures</a></li><li><a href="https://www.psychiatrist.com/sexual-health/">Sexual Dysfunction</a></li><li><a href="https://www.psychiatrist.com/side-effects/">Side Effects</a></li><li><a href="https://www.psychiatrist.com/sleep/">Sleep</a></li><li><a href="https://www.psychiatrist.com/somatoform/">Somatoform Disorders</a></li><li><a href="https://www.psychiatrist.com/stroke/">Stroke</a></li><li><a href="https://www.psychiatrist.com/suicide/">Suicide</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>T</h1><ul><li><a href="https://www.psychiatrist.com/tardive-dyskinesia/">Tardive Dyskinesia</a></li><li><a href="https://www.psychiatrist.com/trauma/">Trauma</a></li><li><a href="https://www.psychiatrist.com/tbi/">Traumatic Brain Injury</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>V</h1><ul><li><a href="https://www.psychiatrist.com/veterans-health/">Veterans and Military Issues</a></li><li><a href="https://www.psychiatrist.com/violence/">Violence and Aggression</a></li></ul></div></div><div class="col-6 col-md-4"><div class="text-thumb"><h1>W</h1><ul><li><a href="https://www.psychiatrist.com/weight-management/">Weight</a></li><li><a href="https://www.psychiatrist.com/womens-health/">Women</a></li></ul></div></div></div>  </div>  <div class="r-sidebar col-12 col-md-5 col-lg-4 for_desktop" data-sidebar="home"> <div class="textwidget"><div class="widget-area"> <div class="g-ad-apart boder-x"><div class="gad-square addlong"> <div id="ad-Ros_Right_Sidebar_1"><p class="advertisement">Advertisement</p><script> googletag.cmd.push(function() { googletag.display('ad-Ros_Right_Sidebar_1'); }); </script></div> 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Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1 First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2). Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. 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