CINXE.COM
Inxight Drugs
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NCATS Inxight incorporates and unifies a wealth of data, including marketing and regulatory status, rigorous drug ingredient definitions, biological activity, clinical use and more." /> <meta name="twitter:description" value="The National Center for Advancing Translational Sciences has developed Inxight Drugs — a comprehensive portal for drug development information.NCATS Inxight incorporates and unifies a wealth of data, including marketing and regulatory status, rigorous drug ingredient definitions, biological activity, clinical use and more." /> <meta property="og:image" content='https://drugs.ncats.io/assets/ginas/images/inxight_main.jpg?w=500' /> <meta name="twitter:image" content='https://drugs.ncats.io/assets/ginas/images/inxight_main.jpg?w=500' /> <meta name="twitter:label1" value="US Approved Drugs" /> <meta name="twitter:data1" value="2638" /> <meta name="twitter:label2" value="Total Substances" /> <meta name="twitter:data2" value="167131" /> <!--[if lte IE 9]> <style 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id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search" id="main-menu-search"> <div class="input-group" id = "search-bar"> <input type="text" class="form-control" id="search" aria-label="Search Substances" title="Search Substances in Inxight Drugs" placeholder= "Search Substances..." ng-model = "query" typeahead-popup-template-url='/assets/templates/elements/suggest-popup.html' uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" typeahead-on-select="onSelect($item, $model, $label)" typeahead-loading="loadingSuggest" typeahead-focus-first ="false" autocomplete="off"> <span class="input-group-btn"> <div class="btn-group search-btn" uib-dropdown> <button id="split-button-main" class="btn btn-default" type="search" aria-label="Search Substances" ng-click = "submitq(query,'/principals')"> <span class="sr-only">Search Substances</span> <span class="fa fa-search"></span> </button> </div> </span> </div> </form> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="loupe" ng-click="showsearch=!showsearch; showclose=!showclose" ng-class="(!showclose)?'':'hidden-sm hidden-xs'"> <i class="fa fa-search" aria-hidden="true"></i> </a> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="close-loupe" ng-class="(showclose)?'':'hidden-sm hidden-xs'" ng-click="showclose=!showclose; showsearch=!showsearch"> <i class="fa fa-times-circle" aria-hidden="true"></i> </a> </li> </ul> </div> </div> <div class="container" id="h-menu"> <div ng-class="(!showsearchHMenu)?'':'hidden-sm hidden-xs'" class="col-xs-10 col-sm-11 col-md-9 col-lg-7 nopadding" id="hmenu-butt-wrap"> <ul class="nav navbar-nav"> <li class="active"> <a href="/" title="Return Home" target="_self" alt ="Home" aria-label="Return Home"> <span class="hidden-xs hidden-sm">Home</span> <i class="fa fa-lg fa-home hidden-md hidden-lg hidden-xl"></i> </a> </li> <li class="dropdown"> <a href="" data-toggle="dropdown" class="dropdown-toggle" aria-expanded="false" title="Drugs by Development Status..."> <span class="hidden-xs hidden-sm">Browse Drugs</span> <i class="fa fa-lg fa-list-ol hidden-md hidden-lg hidden-xl"></i> <i class="fa fa-caret-down"></i> </a> <ul class="dropdown-menu"> <li> <a target="_self" href="/drugs" title="US Approved Drugs"> <span>US Approved Drugs</span> </a> </li> <li> <a target="_self" href="/marketeds" title="Drugs Marketed Somewhere in the World"> <span>Marketed Drugs</span> </a> </li> <li> <a target="_self" href="/clinicals" title="Investigational Drugs"> <span>Investigational Drugs</span> </a> </li> <li> <a target="_self" href="/substances" title="All Substances"> <span>All Substances</span> </a> </li> </ul> </li> <li class="dropdown"> <a href="" data-toggle="dropdown" class="dropdown-toggle" aria-expanded="false" title="Advanced Search..."> <span class="hidden-xs hidden-sm">Search <i class="fa fa-plus-circle"></i></span> <i class="fa fa-lg fa-search-plus hidden-md hidden-lg hidden-xl"></i> <i class="fa fa-caret-down"></i> </a> <ul class="dropdown-menu"> <li> <a ng-href="/structure" ng-click="clearStructure()" target="_self" title="Search by Structure"> <span>Structure Search</span> </a> </li> <li> <a ng-href="/sequence" ng-click="clearStructure()" target="_self" title="Search by Sequence"> <span>Sequence Search</span> </a> </li> </ul> </li> <li> <a ng-href="/downloads-public" target="_self" title="Public Downloads"> <span class="hidden-xs hidden-sm">Downloads</span> <i class="fa fa-lg fa-download hidden-md hidden-lg hidden-xl"></i> </a> </li> <li> <a ng-href="/about" target="_self" title="About NCATS Inxight Drugs"> <span class="hidden-xs hidden-sm">About</span> <i class="fa fa-lg fa-question-circle hidden-md hidden-lg hidden-xl"></i> </a> </li> </ul> </div> <div class="col-md-3 col-lg-5 nopadding" id="menubar"> <ul class="nav navbar-nav pull-right"> <li ng-class="(showsearchHMenu)?'':'hidden-sm hidden-xs'" ng-controller="TypeAheadController" id="hmenu-li-search-wrap"> <div ng-cloak ="" ng-show="loadingSuggestHMenu" id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search" id="main-menu-search"> <div class="input-group" id = "search-bar"> <input type="text" class="form-control" id="search" aria-label="Search Substances" title="Search Substances in Inxight Drugs" placeholder= "Search Substances..." ng-model = "query" typeahead-popup-template-url='/assets/templates/elements/suggest-popup.html' uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" typeahead-on-select="onSelect($item, $model, $label)" typeahead-loading="loadingSuggestHMenu" typeahead-focus-first ="false" autocomplete="off"> <span class="input-group-btn"> <div class="btn-group search-btn" uib-dropdown> <button id="split-button-main" class="btn btn-default" type="search" aria-label="Search Substances" ng-click = "submitq(query,'/substances')"> <span class="sr-only">Search Substances</span> <span class="fa fa-search"></span> </button> </div> </span> </div> </form> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="loupe" ng-click="showsearchHMenu=!showsearchHMenu; showcloseHMenu=!showcloseHMenu" ng-class="(!showcloseHMenu)?'':'hidden-sm hidden-xs'"> <i class="fa fa-search" aria-hidden="true"></i> </a> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="close-loupe" ng-class="(showcloseHMenu)?'':'hidden-sm hidden-xs'" ng-click="showcloseHMenu=!showcloseHMenu; showsearchHMenu=!showsearchHMenu"> <i class="fa fa-times-circle" aria-hidden="true"></i> </a> </li> </ul> </div> </div> </nav> </div> <div class="container" id="content" > <div ng-cloak ="" class="row"> <div ng-hide="hideall" class="col-md-3" id="facet-col"> <div class="btn btn-primary hidden-md hidden-lg filtertoggle" ng-hide="forceFilters" ng-click ='forceFilters = !forceFilters'> <i class="fa fa-filter"></i> Show Filters </div> <div class="btn btn-primary hidden-md hidden-lg filtertoggle" id="hide-filters" ng-show="forceFilters" ng-click ='forceFilters = !forceFilters'> <i class="fa fa-filter"></i> Hide Filters </div> <div ng-class="(forceFilters)?'':'hidden-sm hidden-xs'" class="panel-group"> <div class="panel-group"> <div ng-cloak class="fade-ng-cloak ng-cloak" ng-controller="FiltersController"> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Development+Status&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Development Status","values":[{"label":"Other","count":130534},{"label":"Clinical","count":13501},{"label":"Possibly Marketed Outside US","count":13362},{"label":"US Approved Rx","count":4602},{"label":"US Previously Marketed","count":2936},{"label":"US Approved Allergenic Extract","count":772},{"label":"US Approved OTC","count":752},{"label":"Designated","count":434},{"label":"Discontinued","count":138},{"label":"Excipient","count":52},{"label":"Withdrawn","count":41},{"label":"US Animal Drug","count":5}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Development+Status&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=false;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 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id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Primary+Target&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Primary Target","values":[{"label":"Histamine H1 receptor","count":316},{"label":"Dopamine D2 receptor","count":311},{"label":"DNA","count":282},{"label":"Serotonin 2a (5-HT2a) receptor","count":237},{"label":"Bacterial penicillin-binding protein","count":234},{"label":"Mu opioid receptor","count":231},{"label":"Acetylcholinesterase","count":209},{"label":"Beta-2 adrenergic receptor","count":209},{"label":"GABA-A receptor; anion channel","count":203},{"label":"Cyclooxygenase-2","count":201},{"label":"Norepinephrine transporter","count":197},{"label":"Dopamine transporter","count":183},{"label":"Serotonin transporter","count":183},{"label":"Bacterial 70S ribosome","count":180},{"label":"Serotonin 1a (5-HT1a) receptor","count":177},{"label":"Glucocorticoid receptor","count":173},{"label":"Adrenergic receptor alpha-1","count":171},{"label":"Androgen Receptor","count":169},{"label":"Muscarinic acetylcholine receptor M1","count":168},{"label":"Beta-1 adrenergic receptor","count":163}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Primary+Target&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=false;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Highest+Phase&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Highest Phase","values":[{"label":"Approved","count":8583},{"label":"Phase II","count":1147},{"label":"Phase III","count":665},{"label":"Not Provided","count":511},{"label":"Phase I","count":438},{"label":"Phase IV","count":63}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Highest+Phase&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=false;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Approval+Year&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Approval Year","values":[{"label":"Unknown","count":149123},{"label":"1921","count":1468},{"label":"2024","count":711},{"label":"2020","count":691},{"label":"2012","count":608},{"label":"2013","count":589},{"label":"2011","count":587},{"label":"2014","count":503},{"label":"2016","count":494},{"label":"2010","count":474},{"label":"2015","count":472},{"label":"2021","count":460},{"label":"2023","count":446},{"label":"2018","count":425},{"label":"2017","count":411},{"label":"2009","count":364},{"label":"2019","count":334},{"label":"2022","count":324},{"label":"2007","count":239},{"label":"1996","count":224}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Approval+Year&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Condition&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Condition","values":[{"label":"Unknown","count":2596},{"label":"Pain","count":619},{"label":"Cancer","count":609},{"label":"Hypertension","count":575},{"label":"Breast cancer","count":432},{"label":"Rheumatoid arthritis","count":320},{"label":"Schizophrenia","count":305},{"label":"Alzheimer’s disease","count":278},{"label":"Anxiety","count":275},{"label":"Type 2 diabetes mellitus","count":262},{"label":"Asthma","count":244},{"label":"Depression","count":240},{"label":"Bacterial infections","count":235},{"label":"Parkinson's disease","count":232},{"label":"Non-small cell lung cancer","count":211},{"label":"Urinary tract infections","count":207},{"label":"Obesity","count":206},{"label":"Prostate cancer","count":186},{"label":"Major depressive disorder","count":179},{"label":"Chronic obstructive pulmonary disease","count":175}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Condition&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Treatment+Modality&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Treatment Modality","values":[{"label":"Primary","count":9756},{"label":"Curative","count":2071},{"label":"Palliative","count":1815},{"label":"Preventing","count":1432},{"label":"Diagnostic","count":815},{"label":"Inactive ingredient","count":315},{"label":"Secondary","count":282},{"label":"Preventive","count":11},{"label":"Inactive Ingredient","count":2}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Treatment+Modality&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=CNS+Activity&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"CNS Activity","values":[{"label":"CNS Active","count":4002},{"label":"CNS Penetrant","count":2588},{"label":"CNS Non-penetrant","count":1040}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=CNS+Activity&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Originator&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Originator","values":[{"label":"Pfizer","count":420},{"label":"Eli Lilly","count":239},{"label":"Merck","count":238},{"label":"GlaxoSmithKline","count":197},{"label":"Novartis","count":177},{"label":"Bayer","count":150},{"label":"Bristol-Myers Squibb","count":144},{"label":"Hoffman-La Roche","count":135},{"label":"AstraZeneca","count":131},{"label":"Boehringer Ingelheim","count":130},{"label":"Wyeth","count":117},{"label":"Abbott","count":94},{"label":"Roche","count":93},{"label":"Ciba-Geigy","count":87},{"label":"Imperial Chemical Industries","count":80},{"label":"Takeda Pharmaceutical","count":69},{"label":"Ulex, G.L.","count":66},{"label":"Moissan, H.","count":65},{"label":"Sanofi-Aventis","count":63},{"label":"Parke Davis","count":58}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Originator&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Class&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Substance Class","values":[{"label":"chemical","count":120801},{"label":"structurallyDiverse","count":27755},{"label":"protein","count":7339},{"label":"concept","count":4869},{"label":"mixture","count":2999},{"label":"polymer","count":2556},{"label":"nucleicAcid","count":645},{"label":"specifiedSubstanceG1","count":165}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Class&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=INN+Stem&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"INN Stem","values":[{"label":"Chemical substance(-ine)","count":351},{"label":"Monoclonal antibodies(-mab)","count":199},{"label":"Tyrosine-kinase inhibitors(-tinib)","count":105},{"label":"Peptides and glycopeptides(-tide)","count":95},{"label":"Gene Therapy vectors(-vec)","count":85},{"label":"Antiviral drug(-vir)","count":37},{"label":"Prostaglandin analogue(-prost-)","count":17},{"label":"PARP inhibitor(-parib)","count":7},{"label":"Barbiturates(-barb-)","count":6},{"label":"Chimeric antibody that responds to more than one antigen(-ximab)","count":6},{"label":"Humanized antibody(-zumab)","count":6},{"label":"Platelet aggregation inhibitor(-grel-)","count":4},{"label":"Beta-blockers(-olol)","count":3},{"label":"Angiotensin converting enzyme inhibitor(-pril)","count":1},{"label":"Cephem-type antibiotics(cef-)","count":1},{"label":"Direct Xa inhibitor(-xaban)","count":1},{"label":"HMG-CoA reductase inhibitor(-vastatin)","count":1},{"label":"Inhibitor of PDE5 with vasodilator action(-afil)","count":1},{"label":"Proton-pump inhibitor(-prazole)","count":1}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=INN+Stem&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=GInAS+Tag&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"GInAS Tag","values":[{"label":"KEW","count":3295},{"label":"84371-57-3","count":1},{"label":"ATN-3","count":1},{"label":"PUBLIC DOMAIN RELEASE","count":1},{"label":"test","count":1}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=GInAS+Tag&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Code+System&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Code System","values":[{"label":"FDA UNII","count":161647},{"label":"CAS","count":123190},{"label":"PUBCHEM","count":117144},{"label":"EPA CompTox","count":83349},{"label":"ECHA (EC/EINECS)","count":34343},{"label":"WIKIPEDIA","count":27309},{"label":"NSC","count":26077},{"label":"SMS_ID","count":25232},{"label":"NCI_THESAURUS","count":20449},{"label":"EVMPD","count":16674},{"label":"MERCK INDEX","count":16658},{"label":"DAILYMED","count":14687},{"label":"RXCUI","count":13895},{"label":"ChEMBL","count":12698},{"label":"NCBI TAXONOMY","count":12587},{"label":"Catalogue of Life","count":12470},{"label":"INN","count":12173},{"label":"DRUG BANK","count":11880},{"label":"CHEBI","count":11186},{"label":"MESH","count":10892}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Code+System&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Protein+Type&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Protein Type","values":[{"label":"MONOCLONAL ANTIBODY","count":1031},{"label":"PEPTIDE","count":992},{"label":"ENZYME","count":546},{"label":"RECEPTOR","count":400},{"label":"MONOCLONAL ANTIBODY CONJUGATE","count":168},{"label":"BISPECIFIC ANTIBODY","count":132},{"label":"REGULATOR PROTEIN","count":105},{"label":"CYTOKINE","count":91},{"label":"GROWTH FACTOR","count":78},{"label":"HORMONE","count":78},{"label":"VACCINE ANTIGEN","count":76},{"label":"TRANSPORTER","count":67},{"label":"FUSION PROTEIN","count":58},{"label":"STRUCTURAL PROTEIN","count":46},{"label":"VIRAL STRUCTURAL PROTEIN","count":45},{"label":"FUSION PROTEINS","count":38},{"label":"TRANSCRIPTION FACTOR","count":34},{"label":"PREPROTEIN","count":33},{"label":"VIRAL NON-STRUCTURAL PROTEIN","count":27},{"label":"TOXIN","count":24}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Protein+Type&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+1&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 1","values":[{"label":"NERVOUS SYSTEM","count":525},{"label":"ALIMENTARY TRACT AND METABOLISM","count":511},{"label":"CARDIOVASCULAR SYSTEM","count":416},{"label":"ANTIINFECTIVES FOR SYSTEMIC USE","count":405},{"label":"ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS","count":353},{"label":"DERMATOLOGICALS","count":295},{"label":"RESPIRATORY SYSTEM","count":284},{"label":"VARIOUS","count":257},{"label":"BLOOD AND BLOOD FORMING ORGANS","count":221},{"label":"SENSORY ORGANS","count":207},{"label":"GENITO URINARY SYSTEM AND SEX HORMONES","count":194},{"label":"MUSCULO-SKELETAL 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class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+2&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 2","values":[{"label":"ANTIBACTERIALS FOR SYSTEMIC USE","count":250},{"label":"ANTINEOPLASTIC AGENTS","count":217},{"label":"OPHTHALMOLOGICALS","count":198},{"label":"PSYCHOLEPTICS","count":171},{"label":"CARDIAC THERAPY","count":124},{"label":"PSYCHOANALEPTICS","count":106},{"label":"ANTIVIRALS FOR SYSTEMIC USE","count":88},{"label":"DIAGNOSTIC RADIOPHARMACEUTICALS","count":87},{"label":"ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS","count":86},{"label":"ANALGESICS","count":85},{"label":"DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS","count":79},{"label":"DRUGS FOR OBSTRUCTIVE AIRWAY 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ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any 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ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+4&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 4","values":[{"label":"Antibiotics","count":52},{"label":"Other antineoplastic agents","count":48},{"label":"Protein kinase inhibitors","count":47},{"label":"Enzymes","count":39},{"label":"Benzodiazepine derivatives","count":38},{"label":"Antidotes","count":35},{"label":"Monoclonal antibodies","count":31},{"label":"Antiinflammatory preparations, non-steroids for topical use","count":29},{"label":"Selective immunosuppressants","count":28},{"label":"Other antihistamines for systemic use","count":27},{"label":"Adrenergic and dopaminergic agents","count":26},{"label":"Fluoroquinolones","count":26},{"label":"Other antidepressants","count":25},{"label":"Other cough suppressants","count":25},{"label":"Platelet aggregation inhibitors excl. heparin","count":25},{"label":"Progestogens and estrogens, fixed combinations","count":25},{"label":"Antiinfectives","count":24},{"label":"Antiinfectives and antiseptics for local oral treatment","count":24},{"label":"Glucocorticoids","count":24},{"label":"Other ophthalmologicals","count":24}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+4&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Form&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Substance Form","values":[{"label":"Principal Form","count":141793},{"label":"Salts, Hydrates, Esters, etc.","count":19853}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Form&top=167131&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> </div> </div> </div> </div> <div ng-class="(hideall)?'col-md-12':'col-md-9'"> <div class="fade-in unloaded" ng-hide="hideall" class="panel panel-default" id="allResults"> <div class="panel-heading"> <div class="row"> <div class = "col-md-18" id="showingnumber-pagination-sort"> <div class="col-md-12 col-sm-12 col-xs-12" id="showingnumber-export"> <h4>Showing <span id="record-count" class="label label-default"> 1 - 10 </span> of <span id="record-count" class="label label-default"> 167129 </span> results </h4> <div ng-controller="TypeAheadController" class="pull-right" id="search-within"> <div ng-cloak ="" ng-show="loadingSuggest" id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search"> <div class="input-group"> <input type="text" class="form-control" id="search" aria-label="Search in Current Subset" title="Search in Current Subset" placeholder= "Search in Current Subset..." ng-model = "query" typeahead-popup-template-url="app/assets/templates/elements/suggest-popup.html" uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" typeahead-on-select="onSelect($item, $model, $label)" typeahead-loading="loadingSuggest" typeahead-focus-first ="false" autocomplete="off"> <span class="input-group-btn" style="width:1px"> <div class="btn-group search-btn" uib-dropdown> <button id="split-button-within" class="btn btn-default" type="search" aria-label="Search Substances" ng-click = "searchWithin(query)"> <span class="sr-only">Search within data set</span> <span class="fa fa-search"></span> </button> </div> </span> </div> </form> </div> </div> <div class="btn-group col-xs-9 col-sm-9 col-md-9 nopadding" role="group"> <ul class="pagination"> <li class="disabled"> <a href='/substances?page=1' uib-tooltip="First Page" aria-label="First Page" target="_self"> <span class="sr-only">First page disabled</span> <span aria-hidden="true" class="fa fa-angle-double-left"></span> </a> </li> <li class="disabled"> <a href='/substances?page=1' uib-tooltip="Previous Page" aria-label="Previous Page" target="_self"> <span class="sr-only">Previous page disabled</span> <span aria-hidden="true" class="fa fa-angle-left"></span> </a> </li> <li class="active"> <a href='/substances?page=1' target="_self">1</a> </li> <li> <a href="/substances?page=2" target="_self"> <span aria-hidden="true">2</span> </a> </li> <li> <a href="/substances?page=3" target="_self"> <span aria-hidden="true">3</span> </a> </li> <li> <a href="/substances?page=4" target="_self"> <span aria-hidden="true">4</span> </a> </li> <li class="disabled"> <a href="#" target="_self"> <span><i class="fa fa-ellipsis-h"></i></span> </a> </li> <li> <a href="/substances?page=16712" target="_self"> <span aria-hidden="true">16712</span> </a> </li> <li> <a href="/substances?page=16713" target="_self"> <span aria-hidden="true">16713</span> </a> </li> <li> <a href='/substances?page=2' uib-tooltip="Next Page" aria-label="Next Page" target="_self"> <span class="sr-only">Next page</span> <span aria-hidden="true" class="fa fa-angle-right"></span> </a> </li> <li> <a href='/substances?page=16713' uib-tooltip="Last Page" aria-label="Last Page" target="_self"> <span class="sr-only">Next page</span> <span aria-hidden="true" class="fa fa-angle-double-right"></span> </a> </li> </ul> </div> <div class="btn-group pagination col-xs-3 col-sm-3 col-md-3 nopadding" role="group" id="sortByControl"> <select class="form-control" ng-model= selectedSort ng-change="sortSubstances();" ng-options="r.display for r in sortValues track by r.display" placeholder ="Sort By" title="Sort By" name="SortBy" id ="SortBy" aria-label="Sort By"> <option class= "text-capitalize" value="" selected>Sort By</option> </select> </div> </div> </div> </div> <div class="placeholder-content"> <div class= "panel-body record-container"> <div class = "row in" ng-show="!gridView" id ="list"> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/LOG73M21H5 " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> Suzetrigine </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/LOG73M21H5 " uib-tooltip="view record details" target="_self"> <span class="font-monospace">LOG73M21H5</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('d0464224-403c-c8ae-8522-6080ba57710a', 'aee33bca-8219-4c16-89ed-c73f65afe9a9')" > <rendered id = 'd0464224-403c-c8ae-8522-6080ba57710a' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'aee33bca-8219-4c16-89ed-c73f65afe9a9'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=d0464224-403c-c8ae-8522-6080ba57710a" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2025) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA219209 </div> (2025) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219209">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219209</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2025 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA219209 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219209">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219209</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/PX9FTM69BF " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> VIMSELTINIB </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/PX9FTM69BF " uib-tooltip="view record details" target="_self"> <span class="font-monospace">PX9FTM69BF</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('bf80a4a4-410c-46db-b393-e7b4cf1bb97a', '240b2af4-7691-48b8-b535-0c74fc0bfd5c')" > <rendered id = 'bf80a4a4-410c-46db-b393-e7b4cf1bb97a' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'240b2af4-7691-48b8-b535-0c74fc0bfd5c'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=bf80a4a4-410c-46db-b393-e7b4cf1bb97a" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2025) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA219304 </div> (2025) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219304">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219304</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2025 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA219304 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219304">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219304</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/86K0J5AK6M " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> Mirdametinib </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> <a href=" /drug/86K0J5AK6M " uib-tooltip="view record details" target="_self"> <span class="font-monospace">86K0J5AK6M</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('440138b0-b06f-4a6d-af61-0874a71613aa', '3bea8ff1-c7b3-48b6-8be7-232cb86b0cf0')" > <rendered id = '440138b0-b06f-4a6d-af61-0874a71613aa' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'3bea8ff1-c7b3-48b6-8be7-232cb86b0cf0'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=440138b0-b06f-4a6d-af61-0874a71613aa" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2025) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA219389 </div> (2025) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219389">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219389</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2025 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA219389 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219389">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=219389</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Dual specificity mitogen-activated protein kinase kinase 1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FDual specificity mitogen-activated protein kinase kinase 1"><div class='facet-val-text'>Dual specificity mitogen-activated protein kinase kinase 1</div><span class="badge badge-light">20</span></a></div></div><div class='fval'><div class='facet-val'><a title='Dual specificity mitogen-activated protein kinase kinase 2' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FDual specificity mitogen-activated protein kinase kinase 2"><div class='facet-val-text'>Dual specificity mitogen-activated protein kinase kinase 2</div><span class="badge badge-light">10</span></a></div></div></div></div><hr id='additional-details-separator'> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Conditions:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Non-small cell lung cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FNon-small cell lung cancer"><div class='facet-val-text'>Non-small cell lung cancer</div><span class="badge badge-light">211</span></a></div></div><div class='fval'><div class='facet-val'><a title='Colorectal cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FColorectal cancer"><div class='facet-val-text'>Colorectal cancer</div><span class="badge badge-light">102</span></a></div></div><div class='fval'><div class='facet-val'><a title='Neurofibromatosis' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FNeurofibromatosis"><div class='facet-val-text'>Neurofibromatosis</div><span class="badge badge-light">1</span></a></div></div><div class='fval'><div class='facet-val'><a title='Melanoma' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FMelanoma"><div class='facet-val-text'>Melanoma</div><span class="badge badge-light">88</span></a></div></div><div class='fval'><div class='facet-val'><a title='Breast cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FBreast cancer"><div class='facet-val-text'>Breast cancer</div><span class="badge badge-light">432</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>PD-0325901 is an orally bioavailable inhibitor of mitogen-activated protein kinase kinases (MAPK/ERK kinases or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. PD-0325901 is tested in clinical trials against non-small cell lung cancer, neurofibromatosis, melanoma and breast cancer.</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/CO61ER3EPI " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> TREOSULFAN </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> <a href=" /drug/CO61ER3EPI " uib-tooltip="view record details" target="_self"> <span class="font-monospace">CO61ER3EPI</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('2c1a9c49-e438-4e31-933e-8b5abf3ec951', '345a8a4b-e087-4418-99e8-cf14503b691b')" > <rendered id = '2c1a9c49-e438-4e31-933e-8b5abf3ec951' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'345a8a4b-e087-4418-99e8-cf14503b691b'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=2c1a9c49-e438-4e31-933e-8b5abf3ec951" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2025) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA214759 </div> (2025) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214759">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214759</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2025 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA214759 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214759">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214759</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Apoptosis' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FApoptosis"><div class='facet-val-text'>Apoptosis</div><span class="badge badge-light">156</span></a></div></div><div class='fval'><div class='facet-val'><a title='cell growth' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2Fcell growth"><div class='facet-val-text'>cell growth</div><span class="badge badge-light">21</span></a></div></div><div class='fval'><div class='facet-val'><a title='cell growth' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2Fcell growth"><div class='facet-val-text'>cell growth</div><span class="badge badge-light">21</span></a></div></div></div></div><hr id='additional-details-separator'> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Conditions:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Ewing’s sarcoma' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FEwing’s sarcoma"><div class='facet-val-text'>Ewing’s sarcoma</div><span class="badge badge-light">8</span></a></div></div><div class='fval'><div class='facet-val'><a title='Melanoma' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FMelanoma"><div class='facet-val-text'>Melanoma</div><span class="badge badge-light">88</span></a></div></div><div class='fval'><div class='facet-val'><a title='Multiple myeloma' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FMultiple myeloma"><div class='facet-val-text'>Multiple myeloma</div><span class="badge badge-light">159</span></a></div></div><div class='fval'><div class='facet-val'><a title='Acute myeloid leukemia' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FAcute myeloid leukemia"><div class='facet-val-text'>Acute myeloid leukemia</div><span class="badge badge-light">141</span></a></div></div><div class='fval'><div class='facet-val'><a title='Ovarian cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FOvarian cancer"><div class='facet-val-text'>Ovarian cancer</div><span class="badge badge-light">160</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Treosulfan (l-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan) is a prodrug of a bifunctional alkylating cytotoxic agent that is approved for the treatment of ovarian carcinomas in a number of European countries. The antitumor activity of treosulfan has been shown in a variety of solid tumors. It is used for the treatment of all types of ovarian cancer, either supplementary to surgery or palliatively. Treosulfan is a prodrug that is converted nonenzymatically first to a mono-epoxide – (2S,3S)- 1,2-epoxy-3,4-butanediol-4-methanesulfonate – and then to a diepoxide – l-diepoxybutane, which is also a metabolite of butadiene – under physiological conditions. Such conversions are assumed to account for the alkylating and therapeutic activities of treosulfan.</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/LZ0M43NNF2 " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> Revumenib </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/LZ0M43NNF2 " uib-tooltip="view record details" target="_self"> <span class="font-monospace">LZ0M43NNF2</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = 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"row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA218944 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218944">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218944</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA218944 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218944">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218944</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/T12B44A1OE " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> ACORAMIDIS </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/T12B44A1OE " uib-tooltip="view record details" target="_self"> <span class="font-monospace">T12B44A1OE</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('f59fd15a-080b-a706-4ab7-042c20de0f29', '8d8c99cf-b926-40bd-9fcd-194fc1549ca1')" > <rendered id = 'f59fd15a-080b-a706-4ab7-042c20de0f29' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'8d8c99cf-b926-40bd-9fcd-194fc1549ca1'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=f59fd15a-080b-a706-4ab7-042c20de0f29" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216540 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216540">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216540</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216540 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216540">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216540</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/SHA6U5FJZL " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> DEUTIVACAFTOR </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> <a href=" /drug/SHA6U5FJZL " uib-tooltip="view record details" target="_self"> <span class="font-monospace">SHA6U5FJZL</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('0bda67a0-2620-4fd4-80c7-c04f20cb5dec', 'd4ef3b27-36bb-4e17-a8db-75a626950f79')" > <rendered id = '0bda67a0-2620-4fd4-80c7-c04f20cb5dec' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'d4ef3b27-36bb-4e17-a8db-75a626950f79'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=0bda67a0-2620-4fd4-80c7-c04f20cb5dec" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA218730 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218730">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218730</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA218730 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218730">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218730</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> <div> <div class='text-block'>CTP-656 is a deuterium-modified form of ivacaftor, an FDA-approved drug for the treatment of cystic fibrosis. CTP-656 is jointly developed by Concert Pharmaceuticals and Vertex Pharmaceuticals, and is believed to have higher metabolic stability, lower toxic byproducts and increased half-life compared to the original. CTP-656 acts as a potentiator of is a cystic fibrosis transmembrane conductance regulator (CFTR) protein. CTP-656 is investigated in phase 2 clinical trials for the treatment of cystic fibrosis.</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/9ORI6L73CJ " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> XANOMELINE </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> <a href=" /drug/9ORI6L73CJ " uib-tooltip="view record details" target="_self"> <span class="font-monospace">9ORI6L73CJ</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('b6c4dc87-4999-431a-a551-e73858997751', 'e7537bc5-8a3a-4f78-93ac-34b8da7fd3bf')" > <rendered id = 'b6c4dc87-4999-431a-a551-e73858997751' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'e7537bc5-8a3a-4f78-93ac-34b8da7fd3bf'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=b6c4dc87-4999-431a-a551-e73858997751" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216158 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216158">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216158</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216158 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216158">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216158</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Muscarinic acetylcholine receptor M5' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FMuscarinic acetylcholine receptor M5"><div class='facet-val-text'>Muscarinic acetylcholine receptor M5</div><span class="badge badge-light">63</span></a></div></div><div class='fval'><div class='facet-val'><a title='Muscarinic acetylcholine receptor M1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FMuscarinic acetylcholine receptor M1"><div class='facet-val-text'>Muscarinic acetylcholine receptor M1</div><span class="badge badge-light">168</span></a></div></div><div class='fval'><div class='facet-val'><a title='Muscarinic acetylcholine receptor M4' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FMuscarinic acetylcholine receptor M4"><div class='facet-val-text'>Muscarinic acetylcholine receptor M4</div><span class="badge badge-light">87</span></a></div></div></div></div><hr id='additional-details-separator'> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Conditions:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Alzheimer’s disease' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FAlzheimer’s disease"><div class='facet-val-text'>Alzheimer’s disease</div><span class="badge badge-light">278</span></a></div></div><div class='fval'><div class='facet-val'><a title='Schizophrenia' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FSchizophrenia"><div class='facet-val-text'>Schizophrenia</div><span class="badge badge-light">305</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Xanomeline (LY-246,708) is an orthosteric muscarinic acetylcholine receptor (mAChR) agonist, often referred to as M1/M4-preferring. It is also known to act as a M5 receptor antagonist. Xanomeline was studied in clinical trials phase I in schizophrenia. In Phase II clinical trials in Alzheimer’s patients, xanomeline significantly improved several measures of cognitive function, yet produced unwanted side effects that limited patient compliance. The side effects seem to be associated with rapid metabolism of the alkyloxy side chain following oral administration, resulting in a nonselective, yet active compound with limited therapeutic utility. Despite a second Phase II clinical trial with a patch formulation, the liabilities of xanomeline still outweigh its benefits.</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/5P60F84FBH " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> Givinostat </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> <a href=" /drug/5P60F84FBH " uib-tooltip="view record details" target="_self"> <span class="font-monospace">5P60F84FBH</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('f1fde6b1-14af-4d1f-9db3-24bff92ee5d7', '470daf35-b331-4d22-a088-14eb686b8655')" > <rendered id = 'f1fde6b1-14af-4d1f-9db3-24bff92ee5d7' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'470daf35-b331-4d22-a088-14eb686b8655'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=f1fde6b1-14af-4d1f-9db3-24bff92ee5d7" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA217865 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=217865">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=217865</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA217865 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=217865">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=217865</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Histone deacetylase 2' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHistone deacetylase 2"><div class='facet-val-text'>Histone deacetylase 2</div><span class="badge badge-light">37</span></a></div></div><div class='fval'><div class='facet-val'><a title='Histone deacetylase 3' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHistone deacetylase 3"><div class='facet-val-text'>Histone deacetylase 3</div><span class="badge badge-light">35</span></a></div></div><div class='fval'><div class='facet-val'><a title='Histone deacetylase 6' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHistone deacetylase 6"><div class='facet-val-text'>Histone deacetylase 6</div><span class="badge badge-light">28</span></a></div></div><div class='fval'><div class='facet-val'><a title='Histone deacetylase 7' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHistone deacetylase 7"><div class='facet-val-text'>Histone deacetylase 7</div><span class="badge badge-light">4</span></a></div></div><div class='fval'><div class='facet-val'><a title='Histone deacetylase 1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHistone deacetylase 1"><div class='facet-val-text'>Histone deacetylase 1</div><span class="badge badge-light">51</span></a></div></div><div class='fval'><div class='facet-val'><a title='Histone deacetylase 4' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHistone deacetylase 4"><div class='facet-val-text'>Histone deacetylase 4</div><span class="badge badge-light">11</span></a></div></div></div></div><hr id='additional-details-separator'> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Conditions:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Systemic onset juvenile idiopathic arthritis' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FSystemic onset juvenile idiopathic arthritis"><div class='facet-val-text'>Systemic onset juvenile idiopathic arthritis</div><span class="badge badge-light">3</span></a></div></div><div class='fval'><div class='facet-val'><a title='Polycythemia vera' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FPolycythemia vera"><div class='facet-val-text'>Polycythemia vera</div><span class="badge badge-light">18</span></a></div></div><div class='fval'><div class='facet-val'><a title='Duchenne muscular dystrophy' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FDuchenne muscular dystrophy"><div class='facet-val-text'>Duchenne muscular dystrophy</div><span class="badge badge-light">18</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Gavinostat is an orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Gavinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. It is currently in phase 2 trials for Myeloproliferative disorders, Polycythaemia vera and Phase III for Duchenne muscular dystrophy announced. In clinical trials of givinostat as a salvage therapy for advanced Hodgkin's lymphoma, the most common adverse reactions were fatigue, mild diarrhea or abdominal pain, moderate thrombocytopenia, and mild leukopenia.</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/XX514BJ1XW " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> SULOPENEM </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> <a href=" /drug/XX514BJ1XW " uib-tooltip="view record details" target="_self"> <span class="font-monospace">XX514BJ1XW</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('3aa3a737-44c9-4a10-94b1-be6aef1ae973', '0bc9eb67-4b40-4e5b-b43c-609d5562563b')" > <rendered id = '3aa3a737-44c9-4a10-94b1-be6aef1ae973' ctx='kcpemehzdq'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'0bc9eb67-4b40-4e5b-b43c-609d5562563b'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=3aa3a737-44c9-4a10-94b1-be6aef1ae973" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA213972 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=213972">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=213972</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA213972 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=213972">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=213972</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Penicillin-binding protein 2' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FPenicillin-binding protein 2"><div class='facet-val-text'>Penicillin-binding protein 2</div><span class="badge badge-light">24</span></a></div></div><div class='fval'><div class='facet-val'><a title='Penicillin-binding protein 1A' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FPenicillin-binding protein 1A"><div class='facet-val-text'>Penicillin-binding protein 1A</div><span class="badge badge-light">45</span></a></div></div><div class='fval'><div class='facet-val'><a title='Penicillin-binding protein 1B' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FPenicillin-binding protein 1B"><div class='facet-val-text'>Penicillin-binding protein 1B</div><span class="badge badge-light">22</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Sulopenem is a thiolanylthiopenem derivative patented by American multinational pharmaceutical corporation Pfizer Inc as an antibiotic with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria. Sulopenem showed concentration-dependent bactericidal activities against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter calcoaceticus. Morphological observation using a phase-contrast microscope revealed that sulopenem induced spherical cell formation with E. coli and K. pneumoniae at lower concentrations and bacteriolysis at higher concentrations. Therapeutic efficacies of sulopenem against systemic infections in mice were almost equal to those of imipenem against Streptococcus pneumoniae.</div> </div> </div> </div> </div> <div class = "row hidden-xs" ng-if="gridView" id ="grid"> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/LOG73M21H5" uib-tooltip="view record details" target="_self"> <code>LOG73M21H5</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/LOG73M21H5" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of Suzetrigine" src='/img/d0464224-403c-c8ae-8522-6080ba57710a.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="Suzetrigine"> <a href="/substance/LOG73M21H5" target="_self"> Suzetrigine </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'d0464224-403c-c8ae-8522-6080ba57710a'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=d0464224-403c-c8ae-8522-6080ba57710a" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/PX9FTM69BF" uib-tooltip="view record details" target="_self"> <code>PX9FTM69BF</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/PX9FTM69BF" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of VIMSELTINIB" src='/img/bf80a4a4-410c-46db-b393-e7b4cf1bb97a.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="VIMSELTINIB"> <a href="/substance/PX9FTM69BF" target="_self"> VIMSELTINIB </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'bf80a4a4-410c-46db-b393-e7b4cf1bb97a'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=bf80a4a4-410c-46db-b393-e7b4cf1bb97a" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/86K0J5AK6M" uib-tooltip="view record details" target="_self"> <code>86K0J5AK6M</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/86K0J5AK6M" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of Mirdametinib" src='/img/440138b0-b06f-4a6d-af61-0874a71613aa.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="Mirdametinib"> <a href="/substance/86K0J5AK6M" target="_self"> Mirdametinib </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'440138b0-b06f-4a6d-af61-0874a71613aa'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=440138b0-b06f-4a6d-af61-0874a71613aa" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/CO61ER3EPI" uib-tooltip="view record details" target="_self"> <code>CO61ER3EPI</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/CO61ER3EPI" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of TREOSULFAN" src='/img/2c1a9c49-e438-4e31-933e-8b5abf3ec951.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="TREOSULFAN"> <a href="/substance/CO61ER3EPI" target="_self"> TREOSULFAN </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'2c1a9c49-e438-4e31-933e-8b5abf3ec951'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=2c1a9c49-e438-4e31-933e-8b5abf3ec951" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/LZ0M43NNF2" uib-tooltip="view record details" target="_self"> <code>LZ0M43NNF2</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/LZ0M43NNF2" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of Revumenib" src='/img/0a6b518f-46a2-64ad-d9af-5f4ddd54cae3.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="Revumenib"> <a href="/substance/LZ0M43NNF2" target="_self"> Revumenib </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'0a6b518f-46a2-64ad-d9af-5f4ddd54cae3'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=0a6b518f-46a2-64ad-d9af-5f4ddd54cae3" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/T12B44A1OE" uib-tooltip="view record details" target="_self"> <code>T12B44A1OE</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/T12B44A1OE" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of ACORAMIDIS" src='/img/f59fd15a-080b-a706-4ab7-042c20de0f29.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="ACORAMIDIS"> <a href="/substance/T12B44A1OE" target="_self"> ACORAMIDIS </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'f59fd15a-080b-a706-4ab7-042c20de0f29'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=f59fd15a-080b-a706-4ab7-042c20de0f29" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/SHA6U5FJZL" uib-tooltip="view record details" target="_self"> <code>SHA6U5FJZL</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/SHA6U5FJZL" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of DEUTIVACAFTOR" src='/img/0bda67a0-2620-4fd4-80c7-c04f20cb5dec.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="DEUTIVACAFTOR"> <a href="/substance/SHA6U5FJZL" target="_self"> DEUTIVACAFTOR </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'0bda67a0-2620-4fd4-80c7-c04f20cb5dec'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=0bda67a0-2620-4fd4-80c7-c04f20cb5dec" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/9ORI6L73CJ" uib-tooltip="view record details" target="_self"> <code>9ORI6L73CJ</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/9ORI6L73CJ" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of XANOMELINE" src='/img/b6c4dc87-4999-431a-a551-e73858997751.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="XANOMELINE"> <a href="/substance/9ORI6L73CJ" target="_self"> XANOMELINE </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'b6c4dc87-4999-431a-a551-e73858997751'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=b6c4dc87-4999-431a-a551-e73858997751" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/5P60F84FBH" uib-tooltip="view record details" target="_self"> <code>5P60F84FBH</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/5P60F84FBH" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of Givinostat" src='/img/f1fde6b1-14af-4d1f-9db3-24bff92ee5d7.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="Givinostat"> <a href="/substance/5P60F84FBH" target="_self"> Givinostat </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'f1fde6b1-14af-4d1f-9db3-24bff92ee5d7'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=f1fde6b1-14af-4d1f-9db3-24bff92ee5d7" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/XX514BJ1XW" uib-tooltip="view record details" target="_self"> <code>XX514BJ1XW</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/XX514BJ1XW" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of SULOPENEM" src='/img/3aa3a737-44c9-4a10-94b1-be6aef1ae973.svg?size=200&context=kcpemehzdq'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="SULOPENEM"> <a href="/substance/XX514BJ1XW" target="_self"> SULOPENEM </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'3aa3a737-44c9-4a10-94b1-be6aef1ae973'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=3aa3a737-44c9-4a10-94b1-be6aef1ae973" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> <!-- show pagination at the bottom of the page --> <div class = "col-md-18" id="showingnumber-pagination-sort"> <div class="col-md-12 col-sm-12 col-xs-12" id="showingnumber-export"> <h4>Showing <span id="record-count" class="label label-default"> 1 - 10 </span> of <span id="record-count" class="label label-default"> 167129 </span> results </h4> <div ng-controller="TypeAheadController" class="pull-right" id="search-within"> <div ng-cloak ="" ng-show="loadingSuggest" id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search"> <div class="input-group"> <input type="text" class="form-control" id="search" aria-label="Search in Current Subset" title="Search in Current Subset" placeholder= "Search in Current Subset..." ng-model = "query" typeahead-popup-template-url="app/assets/templates/elements/suggest-popup.html" uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" typeahead-on-select="onSelect($item, $model, $label)" typeahead-loading="loadingSuggest" typeahead-focus-first ="false" autocomplete="off"> <span class="input-group-btn" style="width:1px"> <div class="btn-group search-btn" uib-dropdown> <button id="split-button-within" class="btn btn-default" type="search" aria-label="Search Substances" ng-click = "searchWithin(query)"> <span class="sr-only">Search within data set</span> <span class="fa fa-search"></span> </button> </div> </span> </div> </form> </div> </div> <div class="btn-group col-xs-9 col-sm-9 col-md-9 nopadding" role="group"> <ul class="pagination"> <li class="disabled"> <a href='/substances?page=1' uib-tooltip="First Page" aria-label="First Page" target="_self"> <span class="sr-only">First page disabled</span> <span aria-hidden="true" class="fa fa-angle-double-left"></span> </a> </li> <li class="disabled"> <a href='/substances?page=1' uib-tooltip="Previous Page" aria-label="Previous Page" target="_self"> <span class="sr-only">Previous page disabled</span> <span aria-hidden="true" class="fa fa-angle-left"></span> </a> </li> <li class="active"> <a href='/substances?page=1' target="_self">1</a> </li> <li> <a href="/substances?page=2" target="_self"> <span aria-hidden="true">2</span> </a> </li> <li> <a href="/substances?page=3" target="_self"> <span aria-hidden="true">3</span> </a> </li> <li> <a href="/substances?page=4" target="_self"> <span aria-hidden="true">4</span> </a> </li> <li class="disabled"> <a href="#" target="_self"> <span><i class="fa fa-ellipsis-h"></i></span> </a> </li> <li> <a href="/substances?page=16712" target="_self"> <span aria-hidden="true">16712</span> </a> </li> <li> <a href="/substances?page=16713" target="_self"> <span aria-hidden="true">16713</span> </a> </li> <li> <a href='/substances?page=2' uib-tooltip="Next Page" aria-label="Next Page" target="_self"> <span class="sr-only">Next page</span> <span aria-hidden="true" class="fa fa-angle-right"></span> </a> </li> <li> <a href='/substances?page=16713' uib-tooltip="Last Page" aria-label="Last Page" target="_self"> <span class="sr-only">Next page</span> <span aria-hidden="true" class="fa fa-angle-double-right"></span> </a> </li> </ul> </div> </div> </div> </div> </div> <script> function dismissQuery() { location.assign('/substances'); } $(document).ready(function () { $(function () { $('[data-toggle="popover"]').popover(); }); var firststatus ={"start":1743971625793,"stop":1743971629833,"id":"kcpemehzdq","total":167129,"key":"ae7e8580bcc79d7bbd4e686ac9f7892c9baf83bb","count":167129,"message":null,"status":"Done","determined":true,"finished":true,"results":"https://drugs.ncats.io/api/v1/status(ae7e8580bcc79d7bbd4e686ac9f7892c9baf83bb)/results","generatingUrl":"https://drugs.ncats.io/substances","url":"https://drugs.ncats.io/api/v1/status(ae7e8580bcc79d7bbd4e686ac9f7892c9baf83bb)"}; firststatus.thisPage =10; firststatus.rowsPerPage =10; firststatus.pageTotal =167129; if (!firststatus.finished) { //Only reload if this page isn't ready yet, //OR total isn't determined at this time if (firststatus.count < firststatus.thisPage || !firststatus.total || (firststatus.total != firststatus.pageTotal)) { firststatus.needsReload = true; if (firststatus.count < firststatus.thisPage) { $('.placeholder-content').html('<div>Loading ... </div>' + '<div class="progress multi-progress">' + '<div id="loading-bar1" class="progress-bar progress-bar-striped active" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100">' + '</div>' + +'</div>'); } $('#searching').html('<i class="fa fa-spinner fa-spin"></i> searching...'); //var delay = 0; var checkStatus; var timer; $('#loading').on('hidden.bs.modal', function (e) { window.clearInterval(timer); }); var onDetermined = function () { //window.clearInterval(timer); $('#searching').html(''); //$('#loading').modal('hide'); if (firststatus.needsReload) { $('#searching').html('Reloading search ...'); location.reload(true); } }; var onLoadedMore = function (data) { // loading vs searching.. if (data.total) { if (data.count > firststatus.thisPage || data.finished) { if (firststatus.needsReload) { location.reload(true); } } var pct = Math.floor(100.0 * data.count / firststatus.thisPage + 0.0); pct = Math.min(pct, 100); var loadedPage = Math.floor(data.count / firststatus.rowsPerPage); var 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' + data.count + ' matches'); } }; checkStatus = function () { /* if (delay == 0) { window.clearInterval(timer); delay = 500; timer = window.setInterval(checkStatus, delay); }*/ $.ajax(firststatus.url, { dataType: 'json', }).done(function (status) { if (!firststatus.determined && status.determined) { onDetermined(status); } else { onLoadedMore(status); //console.log(status); checkStatus(); } }).error(function () { //window.clearInterval(timer); }); }; //timer = window.setInterval(checkStatus, delay); checkStatus(); } } }); $(document).ready( function() { var chartJsonUrl = '/chart?searchId=ae7e8580bcc79d7bbd4e686ac9f7892c9baf83bb&facetField=Treatment+Modality'; $.getJSON(chartJsonUrl, function (data) { //'Drugs' or 'Substances' section name //actually, deprecated at the moment, but the code'll stay just in case var sectionName = 'Substances' //console.log(data.labels); data.title = { text: "Number of " + sectionName + " by Treatment Modality" }; //console.log(data.title) data.chart = { type: 'bar' }; data.credits = { enabled: false }; data.navigation = { buttonOptions: { theme: { useHTML: true } } }; data.lang = { printChart: 'Print Chart', saveChart: 'Save Chart...' }; data.exporting = { allowHTML: true, buttons: { contextButton: { enabled: false }, exportButton: { text: '<i class="fa fa-download" aria-hidden="true"></i>', _titleKey: 'saveChart', // Use only the download related menu items from the default context button menuItems: Highcharts.getOptions().exporting.buttons.contextButton.menuItems.splice(2) }, printButton: { text: '<i class="fa fa-print" aria-hidden="true"></i>', _titleKey: 'printChart', onclick: function () { this.print(); } } } }; data.plotOptions = { bar: { datalabels: { enabled: true }, pointWidth: 30, tooltip: { pointFormat: '<b>{point.y}</b>' } } }; data.xAxis = { categories: data.labels, lineWidth: 0, labels: { style: {"fontSize": "14px"} } }; data.yAxis = { title: { text: null }, labels: { style: {"fontSize": "14px"} }, allowDecimals: false }; data.series = [{ data: data.values, name: "Count", showInLegend: false }]; //console.log(data); $(function (data) { //if no labels -- hide chart container if (data.labels.length < 1) { $('#treatment-modality-chart').hide(); //remove flickity carousel cell as well $('.carousel').flickity().flickity( 'remove', $('#treatment-modality-chart').parent(".carousel-cell")); //also check if there are any other cells left - if not, remove carousel if($(".carousel-cell").length === 0){ $(".carousel").remove(); }; } (function (H, data) { //this function renders a chart with fa-icons H.wrap(H.Renderer.prototype, 'label', function (proceed, str, x, y, shape, anchorX, anchorY, useHTML) { if (/class="fa/.test(str)) useHTML = true; //run original proceed method return proceed.apply(this, [].slice.call(arguments, 1)); }); }(Highcharts, data)); $('#treatment-modality-chart').highcharts(data); }(data)); }) }); $(document).ready( function(){ $.getJSON('/chart?searchId=ae7e8580bcc79d7bbd4e686ac9f7892c9baf83bb&facetField=Approval+Year' , function(data){ //Drugs or Substances section name var sectionName = 'Substances' //console.log(sectionName) //console.log(data); var mergedLabels = []; var mergedData = []; var arrayLength = data.labels.length; var kvs = []; for (var i = 0; i < data.labels.length; i++){ var kv={k:data.labels[i], v:data.values[i]}; kvs.push(kv); } var mergedData=_.chain(kvs) .map(function(kv){ kv.k=Math.trunc((kv.k-0)/10)*10; //console.log(kv); return kv; }) .groupBy("k") .toPairs() .map(function(grp){ //console.log(grp); var decade=grp[0]; var count=_.sumBy(grp[1], "v"); return {k:decade, v: count}; }) .value() .sort(function(a,b){return b.k-a.k;}); var values=_.chain(mergedData) .map(function(kv){return kv.v;}) .value(); var keys=_.chain(mergedData) .map(function(kv){return kv.k;}) .value(); //console.log(mergedData); data.title = { text : "Number of " + sectionName + " by Approval Decade" }; //console.log(data.title) data.chart = { type : 'bar' }; data.credits = { enabled: false }; data.navigation = { buttonOptions: { theme: { useHTML: true } } }; data.lang = { printChart: 'Print Chart', saveChart: 'Save Chart...' }; data.exporting = { allowHTML: true, buttons: { contextButton: { enabled: false }, exportButton: { text: '<i class="fa fa-download" aria-hidden="true"></i>', _titleKey: 'saveChart', // Use only the download related menu items from the default context button menuItems: Highcharts.getOptions().exporting.buttons.contextButton.menuItems.splice(2) }, printButton: { text: '<i class="fa fa-print" aria-hidden="true"></i>', _titleKey: 'printChart', onclick: function() { this.print(); } } } }; data.plotOptions = { bar:{datalabels:{ enabled: true }, pointWidth: 30, tooltip: { pointFormat: '<b>{point.y}</b>' } }, columnrange: { dataGrouping : { forced : true } } }; data.xAxis = { categories: keys, lineWidth: 0, labels: { style: {"fontSize":"14px"} }, }; data.yAxis = { title: { text: null }, labels: { style: {"fontSize":"14px"} }, allowDecimals : false }; data.series = [{ data: values, name: "Count", showInLegend: false, }]; //console.log(data.labels); //console.log(data.values); $(function(data) { //if no labels -- remove chart container if(data.labels.length < 1){ $('#approval-date-chart').hide(); //remove flickity carousel cell as well $('.carousel').flickity().flickity( 'remove', $('#approval-date-chart').parent(".carousel-cell")); //also check if there are any other cells left - if not, remove carousel if($(".carousel-cell").length === 0){ $(".carousel").remove(); }; } (function (H,data) { //this function renders a chart with fa-icons H.wrap(H.Renderer.prototype, 'label', function (proceed, str, x, y, shape, anchorX, anchorY, useHTML) { if(/class="fa/.test(str)) useHTML = true; 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