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data-sb-field-path=".title">Decades of Leadership in Oncology</h2></div></div><a data-sb-field-path=".button" __metadata="[object Object]" type="Action" class="Action_root__5eDXn Action_secondary__bhUYe Action_large__0Lt9m BannerCTA_button__y1_Xu" role="button" href="/science/"><span class="Action_label__uURx3">Explore Our Approach</span></a></div></div><div class="BannerCTA_mediaContainer__gEYRx"><div class="BannerCTA_mediaFixedWrapper__wYSCW"><div class="BannerCTA_mediaScalingWrapper__dQTQQ"><div class="VideoBlock_root___2PCs BackgroundMedia_root__RH1BM BackgroundMedia_rootBackgroundVideoBlock__v62Ts VideoBlock_rootIsBackground__SmdrO VideoBlock_rootAspectRatio_16_9__zTaA9" data-sb-field-path=".media.0 .media.0.elementId#@id"><video class="VideoBlock_videoContainer__N_0ZZ NativeVideoEmbed_root__3xA9T" autoplay="" muted="" playsinline="" tabindex="-1" disablepictureinpicture=""><source src="https://assets-dam.takeda.com/video/upload/f_auto:video/q_auto/Takeda%20Oncology/Takeda_Oncology_Hero_Banner_Video-science-16x9-large_w7geah_uvhqpr" type="video/mp4" data-sb-field-path=".url#@src"/></video></div></div></div></div><div class="BannerCTA_overlay__2FkXI bg-black" style="opacity:50%"></div></section><section data-section-position="1" data-sb-field-path="sections.1" data-section-name="## Oncology News " data-exclude-from-nav="false" class="global-pt global-pb global-mt global-mb !pt-10 !pl-0 !pb-10 !pr-0 bg-white SectionWrapperWithTitle_root__CxgEB"><div class="Container_root__KEMgE SectionWrapperWithTitle_container__fUhBZ"><header class="SectionTitleContainer_root__FUs5_ text-dark-grey SectionWrapperWithTitle_sectionTitleContainer__c43Eh" data-testid="sectionTitleContainer"><div class="Markdown_root__yL_qp"><h2 id="Oncology News" class="SectionWrapperWithTitle_title__DOcx1" data-sb-field-path=".title">Oncology News</h2></div></header><div class="mt-[-36px] SectionWrapperWithTitle_titleLinkContainer__NGrFb"><a __metadata="[object Object]" type="Link" data-sb-field-path=".link" class="inline-flex items-center hover:text-primary-active SectionWrapperWithTitle_titleLink__nFvZT" role="link" aria-label="View All" href="/news/news-releases/"><span class="">View All</span></a></div><div class="Container_root__KEMgE NewsroomTextTopicsSection_container__2xx0I"><div class="NewsroomTextTopicsSection_topicWrapper__zerg9 border-medium-grey"><article class="NewsroomTextTopicsSection_topic__s9Bp6"><a class="NewsroomTextTopicsSection_topicLink__9JKlR" role="link" href="/news/news-releases/approval-for-fruzaqla-in-japan/"><h3 class="NewsroomTextTopicsSection_topicLinkTitle__LO_HM">Takeda Receives Approval for FRUZAQLA (fruquintinib) in Japan for the Treatment of Unresectable Advanced or Recurrent Colorectal Cancer</h3></a><div class="NewsroomTextTopicsSection_topicDate__YraFf"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" 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14.210526315789473 Z M 18.75 14.210526315789473 L 18.75 12.631578947368421 L 20.3125 12.631578947368421 L 20.3125 14.210526315789473 L 18.75 14.210526315789473 Z M 14.0625 14.210526315789473 L 14.0625 12.631578947368421 L 15.625 12.631578947368421 L 15.625 14.210526315789473 L 14.0625 14.210526315789473 Z M 9.375 17.36842105263158 L 9.375 15.789473684210527 L 10.9375 15.789473684210527 L 10.9375 17.36842105263158 L 9.375 17.36842105263158 Z M 4.6875 17.36842105263158 L 4.6875 15.789473684210527 L 6.25 15.789473684210527 L 6.25 17.36842105263158 L 4.6875 17.36842105263158 Z M 18.75 17.36842105263158 L 18.75 15.789473684210527 L 20.3125 15.789473684210527 L 20.3125 17.36842105263158 L 18.75 17.36842105263158 Z M 14.0625 17.36842105263158 L 14.0625 15.789473684210527 L 15.625 15.789473684210527 L 15.625 17.36842105263158 L 14.0625 17.36842105263158 Z M 9.375 20.526315789473685 L 9.375 18.94736842105263 L 10.9375 18.94736842105263 L 10.9375 20.526315789473685 L 9.375 20.526315789473685 Z M 4.6875 20.526315789473685 L 4.6875 18.94736842105263 L 6.25 18.94736842105263 L 6.25 20.526315789473685 L 4.6875 20.526315789473685 Z M 20.3125 1.5789473684210527 L 25 1.5789473684210527 L 25 23.684210526315788 L 0 23.684210526315788 L 0 1.5789473684210527 L 4.6875 1.5789473684210527 L 4.6875 0 L 6.25 0 L 6.25 2 L 18.75 2 L 18.75 0 L 20.3125 0 L 20.3125 1.5789473684210527 Z M 4.6875 3.1578947368421053 L 1.5625 3.1578947368421053 L 1.5625 6.315789473684211 L 23.4375 6.315789473684211 L 23.4375 3.1578947368421053 L 20.3125 3.1578947368421053 L 20.3125 4.7368421052631575 L 18.75 4.7368421052631575 L 18.75 3.1578947368421053 L 6.25 3.1578947368421053 L 6.25 4.7368421052631575 L 4.6875 4.7368421052631575 L 4.6875 3.1578947368421053 Z M 2 22 L 23 22 L 23 8 L 2 8 L 2 22 Z"></path></svg><span class="NewsroomTextTopicsSection_topicDateText__TfDx8">September 24, 2024</span></div></article></div><div class="NewsroomTextTopicsSection_topicWrapper__zerg9 border-medium-grey"><article class="NewsroomTextTopicsSection_topic__s9Bp6"><a class="NewsroomTextTopicsSection_topicLink__9JKlR" role="link" href="/news/news-releases/approval-from-european-commission-for-fruzaqla/"><h3 class="NewsroomTextTopicsSection_topicLinkTitle__LO_HM">Takeda Receives Approval from European Commission for FRUZAQLA in Previously Treated Metastatic Colorectal Cancer</h3></a><div class="NewsroomTextTopicsSection_topicDate__YraFf"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 25 24" class="NewsroomTextTopicsSection_topicDateIcon__y0w9w" role="img" aria-hidden="false" data-testid="icon-Calendar"><title>Calendar</title><path d="M 9.375 11.052631578947368 L 9.375 9.473684210526315 L 10.9375 9.473684210526315 L 10.9375 11.052631578947368 L 9.375 11.052631578947368 Z M 14.0625 20.526315789473685 L 14.0625 18.94736842105263 L 15.625 18.94736842105263 L 15.625 20.526315789473685 L 14.0625 20.526315789473685 Z M 18.75 11.052631578947368 L 18.75 9.473684210526315 L 20.3125 9.473684210526315 L 20.3125 11.052631578947368 L 18.75 11.052631578947368 Z M 14.0625 11.052631578947368 L 14.0625 9.473684210526315 L 15.625 9.473684210526315 L 15.625 11.052631578947368 L 14.0625 11.052631578947368 Z M 9.375 14.210526315789473 L 9.375 12.631578947368421 L 10.9375 12.631578947368421 L 10.9375 14.210526315789473 L 9.375 14.210526315789473 Z M 4.6875 14.210526315789473 L 4.6875 12.631578947368421 L 6.25 12.631578947368421 L 6.25 14.210526315789473 L 4.6875 14.210526315789473 Z M 18.75 14.210526315789473 L 18.75 12.631578947368421 L 20.3125 12.631578947368421 L 20.3125 14.210526315789473 L 18.75 14.210526315789473 Z M 14.0625 14.210526315789473 L 14.0625 12.631578947368421 L 15.625 12.631578947368421 L 15.625 14.210526315789473 L 14.0625 14.210526315789473 Z M 9.375 17.36842105263158 L 9.375 15.789473684210527 L 10.9375 15.789473684210527 L 10.9375 17.36842105263158 L 9.375 17.36842105263158 Z M 4.6875 17.36842105263158 L 4.6875 15.789473684210527 L 6.25 15.789473684210527 L 6.25 17.36842105263158 L 4.6875 17.36842105263158 Z M 18.75 17.36842105263158 L 18.75 15.789473684210527 L 20.3125 15.789473684210527 L 20.3125 17.36842105263158 L 18.75 17.36842105263158 Z M 14.0625 17.36842105263158 L 14.0625 15.789473684210527 L 15.625 15.789473684210527 L 15.625 17.36842105263158 L 14.0625 17.36842105263158 Z M 9.375 20.526315789473685 L 9.375 18.94736842105263 L 10.9375 18.94736842105263 L 10.9375 20.526315789473685 L 9.375 20.526315789473685 Z M 4.6875 20.526315789473685 L 4.6875 18.94736842105263 L 6.25 18.94736842105263 L 6.25 20.526315789473685 L 4.6875 20.526315789473685 Z M 20.3125 1.5789473684210527 L 25 1.5789473684210527 L 25 23.684210526315788 L 0 23.684210526315788 L 0 1.5789473684210527 L 4.6875 1.5789473684210527 L 4.6875 0 L 6.25 0 L 6.25 2 L 18.75 2 L 18.75 0 L 20.3125 0 L 20.3125 1.5789473684210527 Z M 4.6875 3.1578947368421053 L 1.5625 3.1578947368421053 L 1.5625 6.315789473684211 L 23.4375 6.315789473684211 L 23.4375 3.1578947368421053 L 20.3125 3.1578947368421053 L 20.3125 4.7368421052631575 L 18.75 4.7368421052631575 L 18.75 3.1578947368421053 L 6.25 3.1578947368421053 L 6.25 4.7368421052631575 L 4.6875 4.7368421052631575 L 4.6875 3.1578947368421053 Z M 2 22 L 23 22 L 23 8 L 2 8 L 2 22 Z"></path></svg><span class="NewsroomTextTopicsSection_topicDateText__TfDx8">June 21, 2024</span></div></article></div><div class="NewsroomTextTopicsSection_topicWrapper__zerg9 border-medium-grey"><article class="NewsroomTextTopicsSection_topic__s9Bp6"><a class="NewsroomTextTopicsSection_topicLink__9JKlR" role="link" href="/news/news-releases/takeda-signs-option-agreement-with-ascentage-pharma-to-enter-into-exclusive-global-license-for-olverembatinib/"><h3 class="NewsroomTextTopicsSection_topicLinkTitle__LO_HM">Takeda Signs Option Agreement with Ascentage Pharma to Enter into Exclusive Global License for Olverembatinib, a Third-Generation BCR-ABL Tyrosine Kinase Inhibitor (TKI)</h3></a><div class="NewsroomTextTopicsSection_topicDate__YraFf"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 25 24" class="NewsroomTextTopicsSection_topicDateIcon__y0w9w" role="img" aria-hidden="false" data-testid="icon-Calendar"><title>Calendar</title><path d="M 9.375 11.052631578947368 L 9.375 9.473684210526315 L 10.9375 9.473684210526315 L 10.9375 11.052631578947368 L 9.375 11.052631578947368 Z M 14.0625 20.526315789473685 L 14.0625 18.94736842105263 L 15.625 18.94736842105263 L 15.625 20.526315789473685 L 14.0625 20.526315789473685 Z M 18.75 11.052631578947368 L 18.75 9.473684210526315 L 20.3125 9.473684210526315 L 20.3125 11.052631578947368 L 18.75 11.052631578947368 Z M 14.0625 11.052631578947368 L 14.0625 9.473684210526315 L 15.625 9.473684210526315 L 15.625 11.052631578947368 L 14.0625 11.052631578947368 Z M 9.375 14.210526315789473 L 9.375 12.631578947368421 L 10.9375 12.631578947368421 L 10.9375 14.210526315789473 L 9.375 14.210526315789473 Z M 4.6875 14.210526315789473 L 4.6875 12.631578947368421 L 6.25 12.631578947368421 L 6.25 14.210526315789473 L 4.6875 14.210526315789473 Z M 18.75 14.210526315789473 L 18.75 12.631578947368421 L 20.3125 12.631578947368421 L 20.3125 14.210526315789473 L 18.75 14.210526315789473 Z M 14.0625 14.210526315789473 L 14.0625 12.631578947368421 L 15.625 12.631578947368421 L 15.625 14.210526315789473 L 14.0625 14.210526315789473 Z M 9.375 17.36842105263158 L 9.375 15.789473684210527 L 10.9375 15.789473684210527 L 10.9375 17.36842105263158 L 9.375 17.36842105263158 Z M 4.6875 17.36842105263158 L 4.6875 15.789473684210527 L 6.25 15.789473684210527 L 6.25 17.36842105263158 L 4.6875 17.36842105263158 Z M 18.75 17.36842105263158 L 18.75 15.789473684210527 L 20.3125 15.789473684210527 L 20.3125 17.36842105263158 L 18.75 17.36842105263158 Z M 14.0625 17.36842105263158 L 14.0625 15.789473684210527 L 15.625 15.789473684210527 L 15.625 17.36842105263158 L 14.0625 17.36842105263158 Z M 9.375 20.526315789473685 L 9.375 18.94736842105263 L 10.9375 18.94736842105263 L 10.9375 20.526315789473685 L 9.375 20.526315789473685 Z M 4.6875 20.526315789473685 L 4.6875 18.94736842105263 L 6.25 18.94736842105263 L 6.25 20.526315789473685 L 4.6875 20.526315789473685 Z M 20.3125 1.5789473684210527 L 25 1.5789473684210527 L 25 23.684210526315788 L 0 23.684210526315788 L 0 1.5789473684210527 L 4.6875 1.5789473684210527 L 4.6875 0 L 6.25 0 L 6.25 2 L 18.75 2 L 18.75 0 L 20.3125 0 L 20.3125 1.5789473684210527 Z M 4.6875 3.1578947368421053 L 1.5625 3.1578947368421053 L 1.5625 6.315789473684211 L 23.4375 6.315789473684211 L 23.4375 3.1578947368421053 L 20.3125 3.1578947368421053 L 20.3125 4.7368421052631575 L 18.75 4.7368421052631575 L 18.75 3.1578947368421053 L 6.25 3.1578947368421053 L 6.25 4.7368421052631575 L 4.6875 4.7368421052631575 L 4.6875 3.1578947368421053 Z M 2 22 L 23 22 L 23 8 L 2 8 L 2 22 Z"></path></svg><span class="NewsroomTextTopicsSection_topicDateText__TfDx8">June 14, 2024</span></div></article></div><div class="NewsroomTextTopicsSection_topicWrapper__zerg9 border-medium-grey"><article class="NewsroomTextTopicsSection_topic__s9Bp6"><a class="NewsroomTextTopicsSection_topicLink__9JKlR" role="link" href="/news/news-releases/four-year-results-from-positive-phase-3-hd21-trial/"><h3 class="NewsroomTextTopicsSection_topicLinkTitle__LO_HM">Takeda and Pfizer Announce Four-Year Results from Positive Phase 3 HD21 Trial of Additional ADCETRIS® (brentuximab vedotin) Combination in Frontline Hodgkin Lymphoma</h3></a><div class="NewsroomTextTopicsSection_topicDate__YraFf"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 25 24" class="NewsroomTextTopicsSection_topicDateIcon__y0w9w" role="img" aria-hidden="false" data-testid="icon-Calendar"><title>Calendar</title><path d="M 9.375 11.052631578947368 L 9.375 9.473684210526315 L 10.9375 9.473684210526315 L 10.9375 11.052631578947368 L 9.375 11.052631578947368 Z M 14.0625 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L 18.75 2 L 18.75 0 L 20.3125 0 L 20.3125 1.5789473684210527 Z M 4.6875 3.1578947368421053 L 1.5625 3.1578947368421053 L 1.5625 6.315789473684211 L 23.4375 6.315789473684211 L 23.4375 3.1578947368421053 L 20.3125 3.1578947368421053 L 20.3125 4.7368421052631575 L 18.75 4.7368421052631575 L 18.75 3.1578947368421053 L 6.25 3.1578947368421053 L 6.25 4.7368421052631575 L 4.6875 4.7368421052631575 L 4.6875 3.1578947368421053 Z M 2 22 L 23 22 L 23 8 L 2 8 L 2 22 Z"></path></svg><span class="NewsroomTextTopicsSection_topicDateText__TfDx8">June 1, 2024</span></div></article></div></div></div></section><section data-section-position="2" data-sb-field-path="sections.2" data-section-name="Pipeline" data-exclude-from-nav="false" class="BannerCTA_root__Y1b7h BannerCTA_rootM__Ao8DE text-white"><div class="BannerCTA_contentWrapper__k0vCs"><div class="Container_root__KEMgE BannerCTA_content__eJClf"><div class="BannerCTA_titleWrapper__I20w3"><div class="Markdown_root__yL_qp"><div class="BannerCTA_title__2tOVW" data-sb-field-path=".title"><h2 class="MarkdownTitle_root__u5rUW" id="Oncology Pipeline">Oncology Pipeline</h2><p>Discovering and developing innovative therapies to deliver potentially transformative treatments</p></div></div></div><a data-sb-field-path=".button" __metadata="[object Object]" type="Action" class="Action_root__5eDXn Action_secondary__bhUYe Action_large__0Lt9m BannerCTA_button__y1_Xu" role="button" href="/science/pipeline/"><span class="Action_label__uURx3">Explore Pipeline</span></a></div></div><div class="BannerCTA_mediaContainer__gEYRx"><div class="BannerCTA_mediaFixedWrapper__wYSCW"><div class="BannerCTA_mediaScalingWrapper__dQTQQ"><div class="ImageBlock_root__xPYXG BackgroundMedia_imageBlockContainer__8LQLr" style="aspect-ratio:16/9"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".media.0.url" alt="pipeline" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr BackgroundMedia_root__RH1BM BackgroundMedia_rootImageBlock__ohHlx" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover;background-size:cover;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAGCAMAAADNLv/0AAAAVFBMVEXtwsG1ICHktrOpaWjuxsXUmZXDami4X17Oh4Psv7/apqDSkIqyVlTps7Lgm5nLdHPGUVKlKymTYmGYVVStYFynXlzAeHStSkiSNjXmr62lEhKmKCfkFZDFAAAAPUlEQVQI1wXBhQHAMAzAMBeTcsf0/5+TgJRS02FeAFof0xjw/ukhzm/BY3PRWK8bm4OqyH5shHLGKuLc+gND3wI6pI8c8wAAAABJRU5ErkJggg==")"/><noscript><img data-sb-field-path=".media.0.url" alt="pipeline" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr BackgroundMedia_root__RH1BM BackgroundMedia_rootImageBlock__ohHlx" sizes="100vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Oncology-Pipeline-banner_mmkqcp 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Oncology-Pipeline-banner_mmkqcp 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Oncology-Pipeline-banner_mmkqcp 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Oncology-Pipeline-banner_mmkqcp 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Oncology-Pipeline-banner_mmkqcp 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Oncology-Pipeline-banner_mmkqcp"/></noscript></span></div></div></div></div><div class="BannerCTA_overlay__2FkXI bg-black" style="opacity:30%"></div></section><section data-section-position="3" data-sb-field-path="sections.3" data-section-name="Topics" data-exclude-from-nav="false" class="global-pt global-pb global-mt global-mb !pt-10 !pl-0 !pb-10 !pr-0 bg-white TopicsSection_root__rHf3W SectionWrapperWithTitle_root__CxgEB"><div class="Container_root__KEMgE SectionWrapperWithTitle_container__fUhBZ"><header class="SectionTitleContainer_root__FUs5_ text-dark-grey SectionWrapperWithTitle_sectionTitleContainer__c43Eh" data-testid="sectionTitleContainer"><div class="Markdown_root__yL_qp"><h2 id="About Takeda Oncology" class="SectionWrapperWithTitle_title__DOcx1" data-sb-field-path=".title">About Takeda Oncology</h2></div></header><div data-sb-field-path=".items" class="TopicsSection_grid__KcnCE"><div class="Grid_grid__AHEYI" style="grid-template-columns:repeat(auto-fill, minmax(max(250px, 30%), 1fr))"><div class="Grid_gridItemWrapper___t_uD"><div data-sb-field-path=".0" class="ImageWithLink_root__d2u2x"><div class="ImageWithLink_imageContainer__UU46L"><div class="ImageWithLink_imageOuterWrapper__GZhWp"><div class="ImageWithLink_imageInnerWrapper__hap2j"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1.7777777777777777"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".image.url" alt="science" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover;background-size:cover;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAGCAMAAADNLv/0AAAAeFBMVEWqVUbAnImqkHy6XUylhoF4W0jivJ+/oKDEcl+bbFbsv53DmHqTXk2XTD6bVUm+cV19Y1ORbmqSQjSfUEGrYlW5a1myg3LIrZazk4DDkYyvXkmhhm+Ba0/MloXXppbklIXTkHfPfHK8tpOmdm+lpHmlkpKlc2ypo475rG6/AAAAQklEQVQIHQXBAwLAMAAEsCtWc7bx/x8ugYuLMOvQtQ30LraD1baPSNSoEQg8Y6aEVUB4LhQTUaX39stIXErt3vNOP3pNA7GtpK9sAAAAAElFTkSuQmCC")"/><noscript><img data-sb-field-path=".image.url" alt="science" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" sizes="(max-width: 572px) 80vw, (max-width: 886px) 40vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/science_bwhhfk"/></noscript></span></div></div></div></div><a data-sb-field-path=".titleUrl#@href" class="" role="button" href="/science/"><div class="ImageWithLink_titleWrapper__LTIbY ImageWithLink_titleWrapperClickable__aAecS bg-light-grey"><div class="ImageWithLink_iconImageWrapper__vl6Y_"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".icon.url" alt="microscope icon" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;background-size:contain;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAMAAAC67D+PAAAANlBMVEVHcEzhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCqLmgCFAAAAEnRSTlMAX0VRjhknaX6HBp1yeAtwM1vgR6nAAAAAQklEQVQIHR3BhwHAIAwDMAcy2fz/bGkkJOXSkCSiKxLJnUhSZW+kwxTc8Fvk5guAVD3mhEdjOPeKp8wRxlEAuCXHB1TDAcUhxD/7AAAAAElFTkSuQmCC")"/><noscript><img data-sb-field-path=".icon.url" alt="microscope icon" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" sizes="10vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_48/v1/Takeda%20Oncology/microscope_2_kbr2ef 48w, https://assets-dam.takeda.com/image/upload/c_lfill,w_64/v1/Takeda%20Oncology/microscope_2_kbr2ef 64w, https://assets-dam.takeda.com/image/upload/c_lfill,w_96/v1/Takeda%20Oncology/microscope_2_kbr2ef 96w, https://assets-dam.takeda.com/image/upload/c_lfill,w_128/v1/Takeda%20Oncology/microscope_2_kbr2ef 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/v1/Takeda%20Oncology/microscope_2_kbr2ef 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/v1/Takeda%20Oncology/microscope_2_kbr2ef 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/v1/Takeda%20Oncology/microscope_2_kbr2ef 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/v1/Takeda%20Oncology/microscope_2_kbr2ef 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/v1/Takeda%20Oncology/microscope_2_kbr2ef 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/v1/Takeda%20Oncology/microscope_2_kbr2ef 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/microscope_2_kbr2ef 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/microscope_2_kbr2ef"/></noscript></span></div></div><h5 data-sb-field-path=".title" class="ImageWithLink_title__JNjTu">Science</h5></div></a></div></div><div class="Grid_gridItemWrapper___t_uD"><div data-sb-field-path=".1" class="ImageWithLink_root__d2u2x"><div class="ImageWithLink_imageContainer__UU46L"><div class="ImageWithLink_imageOuterWrapper__GZhWp"><div class="ImageWithLink_imageInnerWrapper__hap2j"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1.7777777777777777"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".image.url" alt="Oncology medicine" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover;background-size:cover;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAGCAMAAADNLv/0AAAAe1BMVEXGw8b18++9uoHa3bna2JS+q6fRw8Tq6ePd19W0nJ7UzcXX0K7u5JOurbTVtqrfoW3Fo6HJvL3RyZrJrpPfq6fCnInRz7rsysXYyYDIs7Pao53nu7PEzX/mz8HGqpTDsaW/m2zEuLShsra5sqHfx3Xp26Di0Kyov8fn1nmMvikoAAAAQklEQVQI1wXBhQHAIAADsOIOc3f//8IlgJS91Qi5AYQw+7rMMYNSDWN0SymiHWs6cWePF9VQdt5/1xlAiHIFvx+tf27KA7zeuU1FAAAAAElFTkSuQmCC")"/><noscript><img data-sb-field-path=".image.url" alt="Oncology medicine" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" sizes="(max-width: 572px) 80vw, (max-width: 886px) 40vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n"/></noscript></span></div></div></div></div><a data-sb-field-path=".titleUrl#@href" class="" role="button" href="/medicines/"><div class="ImageWithLink_titleWrapper__LTIbY ImageWithLink_titleWrapperClickable__aAecS bg-light-grey"><div class="ImageWithLink_iconImageWrapper__vl6Y_"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".icon.url" alt="altText of the image" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;background-size:contain;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKBAMAAAB/HNKOAAAAJ1BMVEVHcEzhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCqNwrDBAAAADXRSTlMAYjdnDH5KV3IeJj+Pn5i0WwAAAENJREFUCNdjYODqSGBgYHCV3AQkKxncGRg4BRiUGBiYxVwMGBi0uVrNVBgMuKJNcxgKmFoDZRhM2BQYmBkmihcKigEA+/oI1qJ/5zIAAAAASUVORK5CYII=")"/><noscript><img data-sb-field-path=".icon.url" alt="altText of the image" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" sizes="10vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_48/v1/Takeda%20Oncology/medicine_2_hnvdeo 48w, https://assets-dam.takeda.com/image/upload/c_lfill,w_64/v1/Takeda%20Oncology/medicine_2_hnvdeo 64w, https://assets-dam.takeda.com/image/upload/c_lfill,w_96/v1/Takeda%20Oncology/medicine_2_hnvdeo 96w, https://assets-dam.takeda.com/image/upload/c_lfill,w_128/v1/Takeda%20Oncology/medicine_2_hnvdeo 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/v1/Takeda%20Oncology/medicine_2_hnvdeo 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/v1/Takeda%20Oncology/medicine_2_hnvdeo 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/v1/Takeda%20Oncology/medicine_2_hnvdeo 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/v1/Takeda%20Oncology/medicine_2_hnvdeo 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/v1/Takeda%20Oncology/medicine_2_hnvdeo 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/v1/Takeda%20Oncology/medicine_2_hnvdeo 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/medicine_2_hnvdeo 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/medicine_2_hnvdeo"/></noscript></span></div></div><h5 data-sb-field-path=".title" class="ImageWithLink_title__JNjTu">Medicines</h5></div></a></div></div><div class="Grid_gridItemWrapper___t_uD"><div data-sb-field-path=".2" class="ImageWithLink_root__d2u2x"><div class="ImageWithLink_imageContainer__UU46L"><div class="ImageWithLink_imageOuterWrapper__GZhWp"><div class="ImageWithLink_imageInnerWrapper__hap2j"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1.5000866100814134"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".image.url" alt="altText of the image" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover;background-size:cover;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAHCAMAAAAGcixRAAAAV1BMVEX9+/bQrI1UODLNs5bn2cn69evctI/+/v79/frq1ryEal758OP8+O/47dnz4cjUvqSviHfozqq9trHZ0cr07+ju59vbt6XOpn+df2+TV0e6nH95VUlZPDerJqYSAAAARElEQVQIHQXBBQLAIAwAsUNbbDDX/79zCSoiqusCqIjEMOwGFdT4494DpUI3/sqJlKbJnT1/njm1EqPL1tMC1Tzjte4HXlAClCL2vE0AAAAASUVORK5CYII=")"/><noscript><img data-sb-field-path=".image.url" alt="altText of the image" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" sizes="(max-width: 572px) 80vw, (max-width: 886px) 40vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/patient_yi4vvo"/></noscript></span></div></div></div></div><a data-sb-field-path=".titleUrl#@href" class="" role="button" href="/patients/"><div class="ImageWithLink_titleWrapper__LTIbY ImageWithLink_titleWrapperClickable__aAecS bg-light-grey"><div class="ImageWithLink_iconImageWrapper__vl6Y_"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".icon.url" alt="patient" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain;background-size:contain;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKBAMAAAB/HNKOAAAAJFBMVEXhJCpHcEzhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrEQGB4AAAADHRSTlNLAC8EYFQUDGwie2dSOExpAAAARElEQVQI12MQVGU3NmYQY07wVGUQc/VgFGAQWqwVnsAgyNpWEs5QwOKgNJGBTUyNYSIDu/AKV0OGDsGiRYIMEQwsOwUBN48LkvcnkywAAAAASUVORK5CYII=")"/><noscript><img data-sb-field-path=".icon.url" alt="patient" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" sizes="10vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_48/v1/Takeda%20Oncology/examination_kzjiz6 48w, https://assets-dam.takeda.com/image/upload/c_lfill,w_64/v1/Takeda%20Oncology/examination_kzjiz6 64w, https://assets-dam.takeda.com/image/upload/c_lfill,w_96/v1/Takeda%20Oncology/examination_kzjiz6 96w, https://assets-dam.takeda.com/image/upload/c_lfill,w_128/v1/Takeda%20Oncology/examination_kzjiz6 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/v1/Takeda%20Oncology/examination_kzjiz6 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/v1/Takeda%20Oncology/examination_kzjiz6 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/v1/Takeda%20Oncology/examination_kzjiz6 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/v1/Takeda%20Oncology/examination_kzjiz6 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/v1/Takeda%20Oncology/examination_kzjiz6 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/v1/Takeda%20Oncology/examination_kzjiz6 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/examination_kzjiz6 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/examination_kzjiz6"/></noscript></span></div></div><h5 data-sb-field-path=".title" class="ImageWithLink_title__JNjTu">Patients</h5></div></a></div></div><div class="Grid_gridItemWrapper___t_uD"><div data-sb-field-path=".3" class="ImageWithLink_root__d2u2x"><div class="ImageWithLink_imageContainer__UU46L"><div class="ImageWithLink_imageOuterWrapper__GZhWp"><div class="ImageWithLink_imageInnerWrapper__hap2j"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1.7777777777777777"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img data-sb-field-path=".image.url" alt="Man in business suit" __metadata="[object Object]" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover;background-size:cover;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAGCAMAAADNLv/0AAAAdVBMVEVfUz/Hsaathnb59uzNysXg4trt2MFgX1fGurbT0cieloPEqpqMbnqypq6sopSSdV26w8E7MSpWW1ahpKKJgXSpqKBTT0qwc1bbxrqOkY9eWFPd4eTz7+Xl1s9/bU/Qv7GIa1OnqbKHd2LAmYbj3tCah3pjY1tEY2a7AAAAQUlEQVQI1wXBhQGAMAADsM7dcHf4/0QSCCI4mZmxgOzlQFeWNqBJsZ3G5bgsCkpXqdvtJz68StXUBY+c+RO10cH/bKUDhkRDHEYAAAAASUVORK5CYII=")"/><noscript><img data-sb-field-path=".image.url" alt="Man in business suit" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_image__Y_mUP" sizes="(max-width: 572px) 80vw, (max-width: 886px) 40vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/New%20Images%20from%20Simo/investor_eqnle9"/></noscript></span></div></div></div></div><a data-sb-field-path=".titleUrl#@href" class="" target="_blank" role="button" rel="noreferrer" href="https://www.takeda.com/investors/"><div class="ImageWithLink_titleWrapper__LTIbY ImageWithLink_titleWrapperClickable__aAecS bg-light-grey"><div class="ImageWithLink_iconImageWrapper__vl6Y_"><div class="ImageBlock_root__xPYXG" style="aspect-ratio:1"><span 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0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKBAMAAAB/HNKOAAAAIVBMVEXhJCpHcEzhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCrhJCoMImqYAAAAC3RSTlMvAE1VJ0JeOBkPaexQlEEAAAA6SURBVAjXYxAUFJR0ZACS0xaByElgUtiCQbBZXc2CQUK1nMmFYVKQWbILg0OqUrALQ+niNKtQBjAAAEHHCx2KQWOBAAAAAElFTkSuQmCC")"/><noscript><img data-sb-field-path=".icon.url" alt="bar chart" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr ImageWithLink_iconImage__TUGm3" sizes="10vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_48/v1/Takeda%20Oncology/bars_jdlvhq 48w, https://assets-dam.takeda.com/image/upload/c_lfill,w_64/v1/Takeda%20Oncology/bars_jdlvhq 64w, https://assets-dam.takeda.com/image/upload/c_lfill,w_96/v1/Takeda%20Oncology/bars_jdlvhq 96w, https://assets-dam.takeda.com/image/upload/c_lfill,w_128/v1/Takeda%20Oncology/bars_jdlvhq 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/v1/Takeda%20Oncology/bars_jdlvhq 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/v1/Takeda%20Oncology/bars_jdlvhq 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/v1/Takeda%20Oncology/bars_jdlvhq 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/v1/Takeda%20Oncology/bars_jdlvhq 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/v1/Takeda%20Oncology/bars_jdlvhq 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/v1/Takeda%20Oncology/bars_jdlvhq 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/bars_jdlvhq 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/v1/Takeda%20Oncology/bars_jdlvhq"/></noscript></span></div></div><h5 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover;background-size:cover;background-position:0% 0%;filter:blur(20px);background-image:url("data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAGCAMAAADNLv/0AAAAdVBMVEXa3MeSiHtugIdviKB2kZqJlpKqnJSsq6dvf5aSkoydp6lXP0Wwv8WqpqHJwsGgsbjs6NrEurZ0lqGPfXdheHrBs6fBr6hNTUhqXVK6p6Glr62TmJTq6s6Rh5jj48d+lKGhqbXTz8iysqXDw72FioqCdHS+vbtEmgfUAAAAQklEQVQIHQXBhQGAMAADsM5dcIeh/59IgkZOfRVzBkBkp75wX+uOkRilvA0ABmGWJyV/vmipmO1BS3TgNdeMab25H3dcA30EaLpFAAAAAElFTkSuQmCC")"/><noscript><img data-sb-field-path=".image.url" alt="altText of the image" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" 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class="SectionTitleContainer_root__FUs5_ text-dark-grey SectionWrapperWithTitle_sectionTitleContainer__c43Eh" data-testid="sectionTitleContainer"><div class="Markdown_root__yL_qp"><h2 class="MarkdownTitle_root__u5rUW SectionWrapperWithTitle_title__DOcx1" id="Our Viewpoints" data-sb-field-path=".title">Our Viewpoints</h2></div></header><div class="mt-[-36px] SectionWrapperWithTitle_titleLinkContainer__NGrFb"><a __metadata="[object Object]" type="Link" data-sb-field-path=".link" class="inline-flex items-center hover:text-primary-active SectionWrapperWithTitle_titleLink__nFvZT" role="link" aria-label="View all" href="/news/our-viewpoints/"><span class="">View all</span></a></div><div class="NewsroomHotNewsSection_articles__6fQdk"><div class="NewsroomHotNewsSection_mainColumn__ezKvS"><article class="NewsroomHotNewsItem_root__7OvIO NewsroomHotNewsItem_rootMainItem__4QTyJ NewsroomHotNewsSection_articleMainItem__yFLyr"><a class="NewsroomHotNewsItem_imageLink__uh1WK" role="link" href="/news/our-viewpoints/living-is-more-than-surviving/"><div class="ImageBlock_root__xPYXG NewsroomHotNewsItem_imageBlock__tQa2A" style="aspect-ratio:16/9"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="Living is More Than Surviving: Balancing Clinical Outcomes with Patient Impact" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr NewsroomHotNewsItem_image__MH0CV" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover"/><noscript><img alt="Living is More Than Surviving: Balancing Clinical Outcomes with Patient Impact" loading="lazy" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:cover" class="ImageBlock_image__2_PsU ImageBlock_imageGlobalBorderRadius__1CbDr NewsroomHotNewsItem_image__MH0CV" sizes="(max-width: 697px) 100vw, 60vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More"/></noscript></span></div></a><div class="NewsroomHotNewsItem_textInfo__D6T99"><div class="NewsroomHotNewsItem_meta__u8Gfr"><span class="NewsroomHotNewsItem_publishDate__5i6D4"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 25 24" class="NewsroomHotNewsItem_icon__chB49" role="img" aria-hidden="false" data-testid="icon-Calendar"><title>Calendar</title><path d="M 9.375 11.052631578947368 L 9.375 9.473684210526315 L 10.9375 9.473684210526315 L 10.9375 11.052631578947368 L 9.375 11.052631578947368 Z M 14.0625 20.526315789473685 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15.789473684210527 L 10.9375 15.789473684210527 L 10.9375 17.36842105263158 L 9.375 17.36842105263158 Z M 4.6875 17.36842105263158 L 4.6875 15.789473684210527 L 6.25 15.789473684210527 L 6.25 17.36842105263158 L 4.6875 17.36842105263158 Z M 18.75 17.36842105263158 L 18.75 15.789473684210527 L 20.3125 15.789473684210527 L 20.3125 17.36842105263158 L 18.75 17.36842105263158 Z M 14.0625 17.36842105263158 L 14.0625 15.789473684210527 L 15.625 15.789473684210527 L 15.625 17.36842105263158 L 14.0625 17.36842105263158 Z M 9.375 20.526315789473685 L 9.375 18.94736842105263 L 10.9375 18.94736842105263 L 10.9375 20.526315789473685 L 9.375 20.526315789473685 Z M 4.6875 20.526315789473685 L 4.6875 18.94736842105263 L 6.25 18.94736842105263 L 6.25 20.526315789473685 L 4.6875 20.526315789473685 Z M 20.3125 1.5789473684210527 L 25 1.5789473684210527 L 25 23.684210526315788 L 0 23.684210526315788 L 0 1.5789473684210527 L 4.6875 1.5789473684210527 L 4.6875 0 L 6.25 0 L 6.25 2 L 18.75 2 L 18.75 0 L 20.3125 0 L 20.3125 1.5789473684210527 Z M 4.6875 3.1578947368421053 L 1.5625 3.1578947368421053 L 1.5625 6.315789473684211 L 23.4375 6.315789473684211 L 23.4375 3.1578947368421053 L 20.3125 3.1578947368421053 L 20.3125 4.7368421052631575 L 18.75 4.7368421052631575 L 18.75 3.1578947368421053 L 6.25 3.1578947368421053 L 6.25 4.7368421052631575 L 4.6875 4.7368421052631575 L 4.6875 3.1578947368421053 Z M 2 22 L 23 22 L 23 8 L 2 8 L 2 22 Z"></path></svg>May 29, 2024</span><span class="NewsroomHotNewsItem_delimiter__8F4IG">|</span><span class="NewsroomHotNewsItem_taxonomy__ulMVk">Patients</span></div><h3 class="NewsroomHotNewsItem_title__kH_K0"><a tabindex="0" class="NewsroomHotNewsItem_titleLink__u_8ln" role="link" href="/news/our-viewpoints/living-is-more-than-surviving/">Living is More Than Surviving: Balancing Clinical Outcomes with Patient Impact</a></h3><p class="NewsroomHotNewsItem_description__RQ_Jf">Over the past several decades, the rapid pace of scientific advancement has catalyzed a revolution in the way we treat cancers. 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Explore their approach, latest news, pipeline, and innovative therapies.","headerPosition":"sticky","visibleInListings":true,"isBackToTopBtnEnabled":true,"addTitleSuffix":false,"socialImage":{"created_at":"2022-10-10T19:27:04Z","public_id":"Takeda Oncology/New Images from Simo/Medicine_cnlk3n","height":2700,"version":1665430024,"uploaded_by":{"id":"04d130f601569775b61d24b8dedb74","type":"user"},"width":4800,"metadata":{"epzciwdjuelllku8ngpo":["0001"]},"secure_url":"https://res.cloudinary.com/takeda/image/upload/v1665430024/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n.jpg","format":"jpg","created_by":{"id":"04d130f601569775b61d24b8dedb74","type":"user"},"resource_type":"image","access_mode":"public","bytes":2067345,"type":"cloudinary.asset","url":"http://res.cloudinary.com/takeda/image/upload/v1665430024/Takeda%20Oncology/New%20Images%20from%20Simo/Medicine_cnlk3n.jpg","__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}},"sections":[{"hideTitle":false,"media":[{"elementId":"","loop":false,"url":"https://assets-dam.takeda.com/video/upload/v1676668648/Takeda%20Oncology/Takeda_Oncology_Hero_Banner_Video-science-16x9-large_w7geah_uvhqpr.mp4","__metadata":{"modelName":"BackgroundVideoBlock","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"BackgroundVideoBlock"}],"titleColor":{"color":"white","__metadata":{"modelName":"ThemeColorPicker","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"ThemeColorPicker"},"excludeFromNavigation":true,"title":"# Decades of Leadership in Oncology\n\n","overlayColor":{"color":"black","__metadata":{"modelName":"ThemeColorPicker","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"ThemeColorPicker"},"displayName":"","button":{"size":"large","style":"secondary","label":"Explore Our Approach","url":"/science/","__metadata":{"modelName":"Action","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"Action"},"heightVariants":"50%","elementId":"","overlayOpacity":50,"__metadata":{"modelName":"BannerCTA","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"BannerCTA"},{"padding":{"top":"10","left":"0","bottom":"10","right":"0"},"backgroundColor":{"color":"white","__metadata":{"modelName":"ThemeColorPicker","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"ThemeColorPicker"},"title":"## Oncology News\n\n","titleColor":{"color":"dark-grey","__metadata":{"modelName":"ThemeColorPicker","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"ThemeColorPicker"},"excludeFromNavigation":false,"dividerColor":{"color":"medium-grey","__metadata":{"modelName":"ThemeColorPicker","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"ThemeColorPicker"},"elementId":"","displayName":"","count":4,"viewAllLink":{"label":"View All","url":"/news/news-releases/","__metadata":{"modelName":"Link","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"Link"},"hideTitle":false,"filterByTaxonomy":[{"displayName":"News Releases","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"77D45030-95BA-4467-B89F-3AE0BFEF908B","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:39Z"},"type":"Taxonomy"}],"__metadata":{"modelName":"NewsroomTextTopicsSection","projectId":"djvoabi3","source":"sourcebit-source-sanity"},"type":"NewsroomTextTopicsSection","articles":[{"content":"* ***Approval Based on Results from Positive, Global, Phase 3 FRESCO-2 Trial***\n* ***FRUZAQLA (fruquintinib) is the First Novel Targeted Therapy in Japan for Metastatic Colorectal Cancer (mCRC) Regardless of Biomarker Status in Over a Decade***\n\n**OSAKA, Japan and CAMBRIDGE, Massachusetts, September 24, 2024** – Takeda [(TSE:4502/NYSE:TAK)](https://www.takeda.com/investors/overview/) today announced that it has received approval from the Japanese Ministry of Health, Labour and Welfare to manufacture and market FRUZAQLA Capsules 1mg/5mg (generic name: fruquintinib), a selective oral inhibitor of vascular endothelial growth factor receptor (VEGFR) -1, -2 and -3, for the treatment of advanced or recurrent colorectal cancer (CRC) that is neither curable nor resectable and that has progressed after chemotherapy.\n\nThe approval is based primarily on the results of the FRESCO-2 trial, a global Phase 3 clinical trial conducted in the United States, Europe, Japan and Australia. The trial compared FRUZAQLA plus best supportive care (BSC) with placebo plus BSC in patients with previously treated metastatic colorectal cancer (mCRC). The FRESCO-2 trial met all primary and key secondary efficacy endpoints and demonstrated consistent benefits in patients who received FRUZAQLA, regardless of the types of therapy the patients had previously received. FRUZAQLA demonstrated a manageable safety profile in the FRESCO-2 trial, with the incidence of adverse events leading to discontinuation being 21% in the placebo plus BSC arm compared to 20% in the FRUZAQLA plus BSC arm.\u003csup\u003e1\u003c/sup\u003e The data from the FRESCO-2 trial were [published](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00772-9/abstract) in *The Lancet* in June 2023.\n\nDr. Takayuki Yoshino, deputy director of hospital, head, Division for the Promotion of Drug and Diagnostic Development, and chief, Department of Gastrointestinal Oncology at the National Cancer Center Hospital East, who served on the FRESCO-2 study Steering Committee, said, “Although the mortality rate of colorectal cancer has been going down in recent years due to early screening and advances in treatment, the 5-year survival rate for metastatic colorectal cancer remains low and new treatment options are much in need. The approval of FRUZAQLA in Japan offers new hope for patients and families of patients with metastatic colorectal cancer, as well as for healthcare personnel involved in colorectal cancer treatment. I feel that it is of great clinical significance.”\n\n“For more than a decade, Takeda has been a leader in advancing the treatment of metastatic colorectal cancer in Japan. With this approval of FRUZAQLA, we are able to further support patients living with this debilitating disease,” said Teresa Bitetti, president of the Global Oncology Business Unit at Takeda. “FRUZAQLA is now approved in the U.S., European Union, Japan and a number of other countries around the world, and we remain committed to bringing this treatment to additional patients with metastatic colorectal cancer around the world who urgently need new therapeutic options.”\n\n## About FRUZAQLA (fruquintinib)\n\nFRUZAQLA is a selective oral inhibitor of all three VEGF receptors (-1, -2 and -3). VEGFR inhibitors play a pivotal role in blocking tumor angiogenesis. FRUZAQLA was designed to have enhanced selectivity that limits off-target kinase activity, allowing for drug exposure achieving sustained target inhibition and flexibility for potential use as part of combination therapy.\n\nTakeda has the exclusive worldwide license to further develop, commercialize, and manufacture fruquintinib outside of mainland China, Hong Kong and Macau. FRUZAQLA was approved by the U.S. Food and Drug Administration (FDA) in November 2023 and by the European Commission (EC) in June 2024. Fruquintinib is developed and marketed in China by HUTCHMED. Fruquintinib was approved for marketing by the China National Medical Products Administration (NMPA) in September 2018 and commercially launched in China in November 2018 under the brand name ELUNATE®.\n\n### JAPAN IMPORTANT SAFETY INFORMATION\n\nPlease consult the FRUZAQLA (fruquintinib) Japan package insert (J-PI) before prescribing.\n\n**WARNING:** FRUZAQLA should be administered only to patients for whom the use of FRUZAQLA is considered appropriate under the supervision of a physician with sufficient knowledge of and experience in cancer chemotherapy at a medical institution where adequate emergency care can be provided. Prior to treatment initiation, the efficacy and risks should be fully explained to the patient and/or his/her family and informed consent should be obtained; Severe gastrointestinal hemorrhage, including fatal cases, has been reported. Patients should be carefully monitored, and if any abnormalities are observed, administration of FRUZAQLA should be withheld and appropriate measures should be taken. If severe hemorrhage occurs, FRUZAQLA should not be re-administered; Gastrointestinal perforation has been reported with some fatal cases. Patients should be carefully monitored, and if any abnormalities are observed, administration of FRUZAQLA should be withheld and appropriate measures should be taken. If gastrointestinal perforation occurs, FRUZAQLA should not be re-administered.\n\n**CONTRAINDICATIONS:** Patients with a history of hypersensitivity to any of the ingredients of FRUZAQLA.\n\n**IMPORTANT PRECAUTIONS:** Hypertension, including hypertensive crisis, may occur. Blood pressure should be measured prior to the initiation of FRUZAQLA treatment and periodically during this treatment; Proteinuria may occur. Urinary protein should be monitored prior to the initiation of FRUZAQLA treatment and periodically during this treatment; If a surgical procedure is to be performed, patients are recommended to withhold FRUZAQLA before the surgery because wound healing may be delayed. Treatment resumption after the surgical procedure should be determined depending on the patient's condition upon confirmation of adequate wound healing.\n\n**PRECAUTIONS CONCERNING PATIENTS WITH SPECIFIC BACKGROUNDS:** **Patients with hypertension:** Hypertension may worsen; **Patients with bleeding diathesis or abnormal coagulation system:** Hemorrhagic events may occur; **Patients with hemorrhage such as gastrointestinal hemorrhage:** Hemorrhage may be enhanced; **Patients with a complication of intra-abdominal inflammation in the gastrointestinal tract, etc.:** Gastrointestinal perforation may occur; **Patients with current or a history of thromboembolism:** Transient ischaemic attack, thrombotic microangiopathy, pulmonary embolism, portal vein thrombosis, deep vein thrombosis, etc. may occur; **Patients with severe hepatic impairment (Child-Pugh Class C):** Since FRUZAQLA is metabolized mainly in the liver, blood concentrations may be increased. There have been no clinical studies conducted in patients with severe hepatic impairment; **Patients with Reproductive Potential:** Women of childbearing potential should be advised to use adequate contraception during treatment with FRUZAQLA and for 2 weeks after the last dose; **Pregnant Women:** FRUZAQLA can be administered to women who are or may be pregnant only if the expected therapeutic benefits outweigh the possible risks associated with this treatment. In a rat embryo-fetal toxicity study, fetal abnormalities and teratogenic effects consisting of fetal external, visceral, and skeletal malformations and visceral and skeletal variations were observed at exposure levels approximately 0.05 times the exposure level (AUC) of FRUZAQLA at the maximum clinical dose (5 mg/day); **Breast-feeding Women:** It is advisable not to breastfeed. FRUZAQLA may pass into breast milk, and infants may experience serious adverse reactions if they are ingested through breast milk; **Pediatric Use:** There have been no clinical studies conducted in pediatric patients.\n\n### ADVERSE REACTIONS:\n\nAny of the adverse reactions listed below may occur. Patients should be closely monitored, and if any such abnormalities are observed, appropriate measures should be taken, including treatment discontinuation. Clinically Significant Adverse Reactions are follows.\n\n**Hypertension:** Hypertension or hypertensive crisis may occur. If an increase in blood pressure is observed, appropriate treatment such as antihypertensive drug administration should be given as necessary, and if necessary, the dose of fruquintinib should be reduced, or fruquintinib administration should be interrupted. If severe or persistent hypertension, or hypertension that cannot be controlled by routine antihypertensive therapy occurs or if a hypertensive crisis occurs, fruquintinib administration should be discontinued; **Skin disorder:** Skin disorder including palmar-plantar erythrodysesthesia syndrome and rash may occur; **Hemorrhage:** Hemorrhage including epistaxis, hematuria, gastrointestinal hemorrhage and hemoptysis may occur. Fatal outcomes have been reported; **Gastrointestinal perforation:** Fatal outcomes have been reported; **Arterial thromboembolic events:** Arterial thromboembolic events including transient ischemic attack and thrombotic microangiopathy may occur; **Venous thromboembolism events:** Venous thromboembolism such as pulmonary embolism, portal vein thrombosis, and deep vein thrombosis may occur; **Posterior reversible encephalopathy syndrome:** If headaches, convulsions, lethargy, confusion, changes in mental function, blindness or other visual disturbances, or neurological impairment are observed, fruquintinib administration should be discontinued, and appropriate measures should be taken, including blood pressure control; **Arterial dissection:** Arterial dissection including aortic dissection may occur.\n\n***For US Prescribing Information:*** https://www.fruzaqla.com/sites/default/files/resources/fruzaqla-prescribing-information.pdf\n\n***For European Union Summary of Product Characteristics:*** https://www.ema.europa.eu/en/medicines/human/EPAR/fruzaqla\n\n\n## About the Phase 3 FRESCO-2 Trial\n\nThe FRESCO-2 study is a multi-regional clinical trial conducted in the U.S., Europe, Japan and Australia investigating FRUZAQLA plus BSC vs placebo plus BSC in patients with previously treated mCRC ([NCT04322539](https://clinicaltrials.gov/study/NCT04322539)). The study met all of its primary and key secondary endpoints, demonstrating that treatment with FRUZAQLA resulted in statistically significant and clinically meaningful improvement in overall survival and progression-free survival. The safety profile of FRUZAQLA in FRESCO-2 was consistent with previously reported fruquintinib monotherapy studies. Results from the study were [presented](https://oncologypro.esmo.org/meeting-resources/esmo-congress-2022/fresco-2-a-global-phase-iii-multiregional-clinical-trial-mrct-evaluating-the-efficacy-and-safety-of-fruquintinib-in-patients-with-refractory-met) at ESMO in September 2022 and subsequently [published](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00772-9/abstract) in *The Lancet* in June 2023.\u003csup\u003e2,1\u003c/sup\u003e\n\n## Takeda’s Commitment to Colorectal Cancer in Japan\n\nCRC is the most prevalent type of cancer in Japan, with an estimated 161,000 new cases and 54,000 deaths in 2023, according to the National Cancer Center’s statistics.\u003csup\u003e3\u003c/sup\u003e While early-stage CRC can be surgically resected, mCRC remains an area of high unmet need with patients awaiting new treatment options, given its poor prognosis and limited treatment options.\u003csup\u003e4-8\u003c/sup\u003e For over a decade, we have contributed to the treatment of patients with late-stage CRC who have limited treatment options and to the advancement of personalized treatment through the provision of innovative medicines and the generation of relevant evidence. Moving forward, we will continue our work to treat patients with CRC and address their unmet needs.\n\n## About Takeda\n\nTakeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R\u0026D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com.\n\n### Media Contacts:\n\n#### Japanese Media\n\nAkiko Manome\n\n[akiko.manome@takeda.com](mailto:akiko.manome@takeda.com)\n\n#### U.S. and International Media\n\nEmma Nash\n\n[emma.nash@takeda.com](mailto:emma.nash@takeda.com)\n\n## Important Notice\n\nFor the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.\n\nThe companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.\n\n## Forward-Looking Statements\n\nThis press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: [https://www.takeda.com/investors/sec-filings-and-security-reports/](https://www.takeda.com/investors/sec-filings-and-security-reports/) or at [www.sec.gov](https://www.sec.gov/). Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.\n\n## Medical Information\n\nThis press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.\n\n## References: \n\n1. Dasari NA, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. Lancet. 2023;402(10395):41-53. doi:10.1016/S0140-6736(23)00772-9.\n2. Dasari NA, et al. LBA25 – FRESCO-2: A global phase 3 multiregional clinical trial (MRCT) evaluating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer. Ann Oncol. 2022 Sep;33(suppl_7): S808-S869. Doi:10.1016/annonc/annonc1089.\n3. Foundation for Promotion of Cancer Research. Cancer Statistics In Japan. Tokyo, Foundation for Promotion of Cancer Research; 2023.\n4. Bando H, et al. Therapeutic landscape and future direction of metastatic colorectal cancer. Nat Rev Gastroenterol Hepatol 2023; 20(5)306-322. doi:10.1038/s41575-022-00736-1.\n5. D'Haene N, et al. Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience. Oncotarget. 2018;9(29):20761-20768. Published 2018 Apr 17. doi:10.18632/oncotarget.25099.\n6. Venderbosch, et al. Mismatch repair status and braf mutation status in metastatic colorectal cancer patients: A pooled analysis of the Cairo, Cairo2, coin, and Focus Studies. Clinical Cancer Res.,2014; 20(20):5322–5330. doi:10.1158/1078-0432.ccr-14-0332.\n7. Koopman, M., et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer. 209;100(2), 266–273. doi:10.1038/sj.bjc.6604867.\n8. Ahcene Djaballah S, et al. HER2 in Colorectal Cancer: The Long and Winding Road From Negative Predictive Factor to Positive Actionable Target.Am Soc Clin Oncol Educ Book. 2022;42:1-14. doi:10.1200/EDBK_351354.\n","taxonomies":[{"displayName":"News Releases","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"77D45030-95BA-4467-B89F-3AE0BFEF908B","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:39Z"},"type":"Taxonomy"}],"slug":"/news/news-releases/approval-for-fruzaqla-in-japan","title":"Takeda Receives Approval for FRUZAQLA (fruquintinib) in Japan for the Treatment of Unresectable Advanced or Recurrent Colorectal Cancer","publishDate":"2024-09-24T18:32:00.000Z","description":"Takeda announces the approval of FRUZAQLA (fruquintinib) by Japan's Ministry of Health, Labour and Welfare for the treatment of unresectable advanced or recurrent colorectal cancer. The approval is based on the successful Phase 3 FRESCO-2 trial.","visibleInListings":true,"__metadata":{"modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"755726c3-ae1d-41f9-b624-24da46e9a41a","createdAt":"2024-09-09T18:31:49Z","updatedAt":"2024-09-24T06:56:40Z"},"type":"Article","featuredImg":{"created_at":"2023-01-31T18:17:13Z","_version":1,"url":"http://assets-dam.takeda.com/image/upload/v1675189033/legacy-dotcom/siteassets/ja-jp/home/takeda_logo.svg","format":"svg","resource_type":"image","created_by":{"id":"553579438111562","type":"accesskey"},"folder_id":"c190ec1e8b89091d82749269dcc568ea96","bytes":3685,"height":599,"metadata":{"epzciwdjuelllku8ngpo":["0001"]},"version":1675189033,"uploaded_by":{"id":"553579438111562","type":"accesskey"},"id":"b75fe16a3c7b8a0b4a272117d2e669af","type":"cloudinary.asset","width":1080,"secure_url":"https://assets-dam.takeda.com/image/upload/v1675189033/legacy-dotcom/siteassets/ja-jp/home/takeda_logo.svg","public_id":"legacy-dotcom/siteassets/ja-jp/home/takeda_logo","access_mode":"public","__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}},{"title":"Takeda Receives Approval from European Commission for FRUZAQLA in Previously Treated Metastatic Colorectal Cancer","content":"* ***Approval Based on Results from Positive, Global, Phase 3 FRESCO-2 Trial***\n* ***FRUZAQLA (fruquintinib) is the First Novel Targeted Therapy in the EU for Metastatic Colorectal Cancer (mCRC) Regardless of Biomarker Status in Over a Decade***\n\n**OSAKA, Japan and CAMBRIDGE, Massachusetts, June 21, 2024** – Takeda ([TSE:4502/NYSE:TAK](https://www.takeda.com/investors/overview/)) today announced that the European Commission (EC) approved FRUZAQLA (fruquintinib) as a monotherapy indicated for the treatment of adult patients with metastatic colorectal cancer (mCRC) who have been previously treated with available standard therapies, including fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapies, anti-VEGF agents, and anti-EGFR agents, and who have progressed on or are intolerant to treatment with either trifluridine-tipiracil or regorafenib. The decision follows a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) on April 25, 2024, and approval by the U.S. Food and Drug Administration (FDA) for adults with mCRC who have been previously treated with oxaliplatin- and irinotecan-based regimens on November 8, 2023.\u003csup\u003e1,2\u003c/sup\u003e\n\n\"People living with metastatic colorectal cancer face numerous difficulties, stemming both from their illness and the adverse effects of therapies. Given the complex nature of the disease, introducing innovative treatments such as fruquintinib – an oral, chemotherapy-free targeted agent – is essential. I am looking forward to having a new choice for appropriate patients,\" said Josep Tabernero, MD, PhD, director of Vall d´Hebron Institute of Oncology (VHIO).\n\nThe approval is based on results from the Phase 3 multi-regional FRESCO-2 trial. The trial investigated FRUZAQLA plus best supportive care (BSC) versus placebo plus BSC in patients with previously treated mCRC. FRESCO-2 met all its primary and key secondary efficacy endpoints and showed consistent benefit among patients treated with FRUZAQLA, regardless of the prior types of therapies they received. FRUZAQLA demonstrated a manageable safety profile in FRESCO-2. Adverse reactions leading to treatment discontinuation occurred in 20% of patients treated with FRUZAQLA plus BSC versus 21% of those treated with placebo plus BSC. Data from FRESCO-2 were [published](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00772-9/abstract) in *The Lancet* in June 2023.\u003csup\u003e3\u003c/sup\u003e\n\n\"Today's approval marks an important moment for the colorectal cancer community in the EU. For the first time in over a decade, patients with previously treated metastatic colorectal cancer have a new targeted treatment option that can be used irrespective of whether their tumors harbor actionable mutations,\" said Teresa Bitetti, president of the Global Oncology Business Unit at Takeda. “We look forward to offering patients a novel treatment option that has a manageable safety profile and can be effective regardless of the prior types of therapies they have received.”\n\n## About FRUZAQLA (fruquintinib)\n\nFRUZAQLA is a selective oral inhibitor of all three VEGF receptors (-1, -2 and -3). VEGFR inhibitors play a pivotal role in blocking tumor angiogenesis. FRUZAQLA was designed to have enhanced selectivity that limits off-target kinase activity, allowing for high drug exposure, sustained target inhibition, and flexibility for potential use as part of combination therapy. \n\nTakeda has the exclusive worldwide license to further develop, commercialize, and manufacture fruquintinib outside of mainland China, Hong Kong and Macau. FRUZAQLA was approved by the U.S. Food and Drug Administration (FDA) in November 2023. A submission to the Japan Pharmaceuticals and Medical Devices Agency (PMDA) took place in September 2023. Fruquintinib is developed and marketed in China by HUTCHMED. Fruquintinib was approved for marketing by the China National Medical Products Administration (NMPA) in September 2018 and commercially launched in China in November 2018 under the brand name ELUNATE®. \n\n## EUROPEAN UNION IMPORTANT SAFETY INFORMATION\n\nPlease consult the FRUZAQLA (fruquintinib) Summary of Product Characteristics (SmPC) before prescribing.\n\n**Guidance for use:** FRUZAQLA should be initiated by a physician experienced in the administration of anticancer therapy. Patients should be given the package leaflet.\n\n**CONTRAINDICATIONS:** Hypersensitivity to the active substance or to any of the excipients. \n\n**SPECIAL POPULATIONS:** **Renal impairment:** No dose adjustment is required for patients with mild, moderate, or severe renal impairment; **Hepatic impairment:** No dose adjustment is required for patients with mild or moderate hepatic impairment. FRUZAQLA is not recommended for use in patients with severe hepatic impairment as FRUZAQLA has not been studied in this population; **Elderly:** No dose adjustment is required in patients aged 65 years or above; **Paediatric population:** There is no relevant use of FRUZAQLA in the paediatric population for the indication of metastatic colorectal cancer; **Women of childbearing potential/Contraception in females:** Women of childbearing potential should be advised to use highly effective contraception during treatment and for at least 2 weeks following the last dose of FRUZAQLA; **Pregnancy:** There are no clinical data available on the use of FRUZAQLA in pregnant women. Based on its mechanism of action, FRUZAQLA has the potential to cause foetal harm. Animal studies have shown reproductive toxicity, including foetal malformations. FRUZAQLA should not be used during pregnancy unless the clinical condition of the woman requires treatment with FRUZAQLA. If FRUZAQLA is used during pregnancy or if the patient becomes pregnant while on treatment, the patient must be informed of the potential hazard to the foetus; **Breast-feeding:** The safe use of FRUZAQLA during breast-feeding has not been established. It is not known whether FRUZAQLA or its metabolites are excreted in human milk. There are no animal data on the excretion of FRUZAQLA in animal milk. A risk to the breastfeeding newborns/infants cannot be excluded. Breastfeeding should be discontinued during treatment and for 2 weeks after the last dose; **Fertility:** There are no data on the effects of FRUZAQLA on human fertility. Results from animal studies indicate that FRUZAQLA may impair male and female fertility. \n\n### SPECIAL WARNINGS AND PRECAUTIONS FOR USE\n\n**Hypertension:** Hypertension, including hypertensive crisis, has been reported in patients treated with FRUZAQLA. Pre-existing hypertension should be monitored and adequately controlled in accordance with standard medical practices before starting FRUZAQLA treatment.\n\nHypertension should be medically managed with antihypertensive medicinal products and adjustment of the FRUZAQLA dose, if necessary. FRUZAQLA should be permanently discontinued for hypertension that cannot be controlled with antihypertensive therapy or in patients with hypertensive crisis.\n\n**Haemorrhagic events:** Haemorrhagic events have been reported in patients treated with FRUZAQLA, including gastrointestinal (GI) tract events. Serious and sometimes fatal bleeding events have been reported in patients after treatment with FRUZAQLA.\n\nHaematologic and coagulation profiles should be monitored in accordance with standard medical practices in patients at risk for bleeding, including those treated with anticoagulants or other concomitant medicinal products that increase the risk of bleeding. In the event of severe bleeding requiring immediate medical intervention, FRUZAQLA should be permanently discontinued.\n\n**Gastrointestinal perforation:** GI perforation events, including fatal events, have been reported in patients treated with FRUZAQLA.\n\nSymptoms of GI perforation should be periodically monitored during treatment with FRUZAQLA.\n\nFRUZAQLA should be permanently discontinued in patients developing GI perforation.\n\n**Proteinuria:** Proteinuria events have occurred in patients treated with FRUZAQLA.\n\nProteinuria should be monitored before initiation and during treatment with FRUZAQLA in accordance with standard medical practices. If urine dipstick proteinuria ≥ 2 g / 24 hours is detected, dose interruptions, adjustments, or discontinuation may be necessary. FRUZAQLA should be permanently discontinued in patients developing nephrotic syndrome.\n\n**Palmar-plantar erythrodysaesthesia syndrome (PPES):** PPES is the most frequently reported dermatological adverse reaction.\n\nIf Grade ≥ 2 skin reactions are detected, dose interruptions, adjustments, or discontinuation may be necessary.\n\n**Posterior reversible encephalopathy syndrome (PRES):** PRES has been reported in 1 patient (0.1%) treated with FRUZAQLA in clinical studies. PRES is a rare neurologic disorder that can present with headache, seizure, lethargy, confusion, altered mental function, blindness, and other visual or neurological disturbances, with or without associated hypertension. A diagnosis of PRES requires confirmation by brain imaging, preferably magnetic resonance imaging (MRI). In patients developing PRES, discontinuation of FRUZAQLA, along with control of hypertension and supportive medical management of other symptoms, are recommended.\n\n**Impaired wound healing:** Impaired wound healing has been reported in 1 patient (0.1%) treated with FRUZAQLA in clinical studies\n\nPatients are recommended to withhold FRUZAQLA for at least 2 weeks prior to surgery. FRUZAQLA should not be resumed for at least 2 weeks after surgery, as clinically indicated when there is evidence of adequate wound healing.\n\n**Arterial and venous thromboembolic events:** It is recommended to avoid starting treatment with FRUZAQLA in patients with a history of thromboembolic events (including deep vein thrombosis and pulmonary embolism) within the past 6 months or if they have a history of stroke and/or transient ischemic attack within the last 12 months. If arterial thrombosis is suspected, FRUZAQLA should be discontinued immediately.\n\n## INTERACTIONS\n\nEffects of other medicinal products on the pharmacokinetics of FRUZAQLA\n\n*CYP3A inducers*\n\nCo-administration of FRUZAQLA with rifampicin (a strong CYP3A inducer) 600 mg once daily decreased FRUZAQLA AUCinf by 65% and decreased C\u003csub\u003emax\u003c/sub\u003e by 12%. The concomitant use of FRUZAQLA with strong and moderate CYP3A inducers should be avoided.\n\n*CYP3A inhibitors*\n\nCo-administration of FRUZAQLA with itraconazole (a strong CYP3A inhibitor) 200 mg twice daily did not result in clinically meaningful changes in the area under the concentration-time curve (AUC) and C\u003csub\u003emax\u003c/sub\u003e of FRUZAQLA. No dose adjustment of FRUZAQLA is needed during concomitant use with CYP3A inhibitors.\n\n*Gastric acid lowering agents*\n\nCo-administration of FRUZAQLA with rabeprazole (a proton pump inhibitor) 40 mg once daily did not result in clinically meaningful changes in the AUC of FRUZAQLA. No dose adjustment of FRUZAQLA is needed during concomitant use with gastric acid lowering agents.\n\nEffect of FRUZAQLA on the pharmacokinetics of other medicinal products\n\n*Medicinal products that are substrates of P-glycoprotein (P-gp)*\n\nCo-administration of a single dose of dabigatran etexilate 150 mg (a P-gp substrate) with a single dose of FRUZAQLA 5 mg decreased AUC of dabigatran by 9%. No dose adjustment is recommended for P-gp substrates during concomitant use with FRUZAQLA.\n\n*Medicinal products that are substrates of breast cancer resistance protein (BCRP)*\n\nCo-administration of a single 10 mg dose of rosuvastatin (a BCRP substrate) with a single 5 mg dose of FRUZAQLA decreased AUC of rosuvastatin by 19%. No dose adjustment is recommended for BCRP substrates during concomitant use with FRUZAQLA.\n\n**UNDESIRABLE EFFECTS:** The **most commonly reported adverse reactions** with FRUZAQLA are:\n\n* **Very common (frequency ≥1/10):** Thrombocytopenia, hypothyroidism, anorexia, hypertension, dysphonia, diarrhoea, stomatitis, aspartate aminotransferase increased, total bilirubin increased, alanine aminotransferase increased, palmar-plantar erythrodysaesthesia syndrome, musculoskeletal discomfort, arthralgia, proteinuria, asthenia, and fatigue\n* **Common (≥1/100 to \u003c1/10):** Pneumonia, upper respiratory tract infection, bacterial infections, leukopenia, neutropenia, hypokalemia, epistaxis, throat pain, gastrointestinal haemorrhage, gastrointestinal perforation, pancreatic enzymes increased, oral pain, rash, and mucosal inflammation\n\n## About CRC\n\nCRC is a cancer that starts in either the colon or rectum. According to the International Agency for Research on Cancer, CRC is the third most prevalent cancer worldwide and was associated with more than 1.9 million new cases and 900,000 deaths in 2022. In Europe, CRC was the second most common cancer in 2022, with approximately 538,000 new cases and 248,000 deaths.\u003csup\u003e4\u003c/sup\u003e In the U.S., it is estimated that 153,000 patients will be diagnosed with CRC and 53,000 deaths from the disease will occur in 2024.\u003csup\u003e5\u003c/sup\u003e In Japan, CRC was the most common cancer in 2022, with more than 145,000 new cases and 60,000 deaths.\u003csup\u003e4\u003c/sup\u003e Although early-stage CRC can be surgically resected, metastatic CRC remains an area of high unmet need with poor outcomes and limited treatment options. Some patients with metastatic CRC may benefit from personalized therapeutic strategies based on molecular characteristics; however, most patients have tumors that do not harbor actionable mutations.\u003csup\u003e6,7,8,9,10\u003c/sup\u003e\n\n## About the Phase 3 FRESCO-2 Trial\n\nThe FRESCO-2 study is a multi-regional clinical trial conducted in the U.S., Europe, Japan and Australia investigating FRUZAQLA plus BSC vs placebo plus BSC in patients with previously treated mCRC ([NCT04322539](https://clinicaltrials.gov/study/NCT04322539)). The study met all of its primary and key secondary endpoints, demonstrating that treatment with FRUZAQLA resulted in statistically significant and clinically meaningful improvement in OS and PFS. The safety profile of FRUZAQLA in FRESCO-2 was consistent with previously reported fruquintinib monotherapy studies. Results from the study were [presented](https://oncologypro.esmo.org/meeting-resources/esmo-congress-2022/fresco-2-a-global-phase-iii-multiregional-clinical-trial-mrct-evaluating-the-efficacy-and-safety-of-fruquintinib-in-patients-with-refractory-met) at ESMO in September 2022 and subsequently [published](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00772-9/abstract) in *The Lancet* in June 2023.\u003csup\u003e11,3\u003c/sup\u003e\n\n## About Takeda \n\nTakeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R\u0026D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit [www.takeda.com](https://www.takeda.com/). \n\n## Media Contacts:\n\n### Japanese Media\n\nJun Saito\n\n[jun.saito@takeda.com](mailto:jun.saito@takeda.com)\n\n### U.S. and International Media\n\nEmma Nash\n\n[emma.nash@takeda.com](mailto:emma.nash@takeda.com)\n\n## Important Notice\n\nFor the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.\n\nThe companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.\n\n## Forward-Looking Statements\n\nThis press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: [https://www.takeda.com/investors/sec-filings-and-security-reports/](https://www.takeda.com/investors/sec-filings-and-security-reports/) or at [www.sec.gov](https://www.sec.gov/). Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.\n\n## Medical Information\n\nThis press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.\n\n## References: \n\n1. Takeda Pharmaceuticals. (2024 April 26). Takeda Receives Positive CHMP Opinion for Fruquintinib in Previously Treated Metastatic Colorectal Cancer [Press Release]. Available [here](https://www.takeda.com/newsroom/newsreleases/2024/positive-chmp-opinion-for-fruquintinib/).\n2.\tTakeda Pharmaceuticals. (2023 November 8). Takeda Receives U.S. FDA Approval of FRUZAQLA™ (fruquintinib) for Previously Treated Metastatic Colorectal Cancer [Press Release]. Available [here](https://www.takeda.com/newsroom/newsreleases/2023/Takeda-Receives-US-FDA-Approval-of-FRUZAQLA-fruquintinib-for-Previously-Treated-Metastatic-Colorectal-Cancer/). \n3.\tDasari NA, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. Lancet. 2023;402(10395):41-53. doi:10.1016/S0140-6736(23)00772-9.\n4.\tBray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 [online ahead of print]. doi: 10.3322/caac.21834 \n5.\tAmerican Cancer Society. Cancer Facts \u0026 Figures 2024. Atlanta, American Cancer Society; 2024.\n6.\tBando H, et al. Therapeutic landscape and future direction of metastatic colorectal cancer. Nat Rev Gastroenterol Hepatol 2023; 20(5)306-322. doi:10.1038/s41575-022-00736-1.\n7.\tD'Haene N, et al. Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience. Oncotarget. 2018;9(29):20761-20768. Published 2018 Apr 17. doi:10.18632/oncotarget.25099.\n8.\tVenderbosch, et al. Mismatch repair status and braf mutation status in metastatic colorectal cancer patients: A pooled analysis of the Cairo, Cairo2, coin, and Focus Studies. Clinical Cancer Res.,2014; 20(20):5322–5330. doi:10.1158/1078-0432.ccr-14-0332.\n9.\tKoopman, M., et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer. 209;100(2), 266–273. doi:10.1038/sj.bjc.6604867.\n10.\tAhcene Djaballah S, et al. HER2 in Colorectal Cancer: The Long and Winding Road From Negative Predictive Factor to Positive Actionable Target.Am Soc Clin Oncol Educ Book. 2022;42:1-14. doi:10.1200/EDBK_351354.\n11.\tDasari NA, et al. LBA25 – FRESCO-2: A global phase 3 multiregional clinical trial (MRCT) evaluating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer. Ann Oncol. 2022 Sep;33(suppl_7): S808-S869. Doi:10.1016/annonc/annonc1089.\n","visibleInListings":true,"taxonomies":[{"displayName":"News Releases","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"77D45030-95BA-4467-B89F-3AE0BFEF908B","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:39Z"},"type":"Taxonomy"}],"description":"Takeda secures European Commission approval for FRUZAQLA (fruquintinib), a novel targeted therapy for previously treated metastatic colorectal cancer. Learn about the Phase 3 FRESCO-2 trial results. ","slug":"/news/news-releases/approval-from-european-commission-for-fruzaqla","publishDate":"2024-06-21T16:42:00.000Z","__metadata":{"modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"6ae42cd3-008d-4ed2-8e61-cb48d9f9d38e","createdAt":"2024-06-07T16:23:11Z","updatedAt":"2024-06-21T19:55:30Z"},"type":"Article","featuredImg":{"created_at":"2023-01-31T18:17:13Z","_version":1,"url":"http://assets-dam.takeda.com/image/upload/v1675189033/legacy-dotcom/siteassets/ja-jp/home/takeda_logo.svg","format":"svg","resource_type":"image","created_by":{"id":"553579438111562","type":"accesskey"},"folder_id":"c190ec1e8b89091d82749269dcc568ea96","bytes":3685,"height":599,"metadata":{"epzciwdjuelllku8ngpo":["0001"]},"version":1675189033,"uploaded_by":{"id":"553579438111562","type":"accesskey"},"id":"b75fe16a3c7b8a0b4a272117d2e669af","type":"cloudinary.asset","width":1080,"secure_url":"https://assets-dam.takeda.com/image/upload/v1675189033/legacy-dotcom/siteassets/ja-jp/home/takeda_logo.svg","public_id":"legacy-dotcom/siteassets/ja-jp/home/takeda_logo","access_mode":"public","__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}},{"publishDate":"2024-06-14T17:00:00.000Z","title":"Takeda Signs Option Agreement with Ascentage Pharma to Enter into Exclusive Global License for Olverembatinib, a Third-Generation BCR-ABL Tyrosine Kinase Inhibitor (TKI)","description":"Takeda signs option agreement with Ascentage Pharma to enter into exclusive license agreement for third-generation BCR-ABL TKI in development for CML.","taxonomies":[{"displayName":"News Releases","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"77D45030-95BA-4467-B89F-3AE0BFEF908B","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:39Z"},"type":"Taxonomy"}],"visibleInListings":true,"content":"* ***Takeda to Receive Exclusive Option to License Global Rights to Olverembatinib in All Territories Outside of Mainland China, Hong Kong, Macau, Taiwan and Russia***\n* ***Olverembatinib Has the Potential to Address Significant Unmet Need for Patients with Chronic Myeloid Leukemia Following Treatment with Currently Approved TKIs***\n* ***Ascentage Pharma to Advance Late-Stage Clinical Development of Olverembatinib Prior to Potential Exercise of the Option to License***\n\n**OSAKA, Japan and CAMBRIDGE, Massachusetts, June 14, 2024** – Takeda ([TSE:4502/NYSE:TAK](https://www.takeda.com/investors/overview/)) today announced the signing of an option agreement with Ascentage Pharma to enter into an exclusive license agreement for olverembatinib, an oral, potentially best-in-class, third-generation BCR-ABL tyrosine kinase inhibitor (TKI), which is currently in development for chronic myeloid leukemia (CML) and other hematological cancers. If exercised, the option would allow Takeda to license global rights to develop and commercialize olverembatinib in all territories outside of mainland China, Hong Kong, Macau, Taiwan and Russia. \n\nDespite the impact TKIs have had in the treatment of patients with CML, there remains significant unmet need for patients whose disease is resistant or refractory to these therapies or who develop hard-to-treat mutations following these treatments. \n\n“Takeda has a long history of driving important treatment advances for patients, particularly those with hematological cancers facing treatment gaps,” said Teresa Bitetti, president of the Global Oncology Business Unit at Takeda. “We are highly encouraged by the promising results olverembatinib has shown in the clinic to date and excited to have the opportunity to potentially further develop and deliver it to patients with chronic myeloid leukemia and other hematological cancers. This agreement aligns with our goal to support the advancement of both internal and external innovation to best serve patients.”\n\nAs part of the agreement, Ascentage Pharma will continue to be solely responsible for all clinical development of olverembatinib prior to potential exercise of the option to license. Olverembatinib is currently approved and marketed in China for the treatment of adult patients with TKI-resistant chronic-phase CML (CP-CML) or accelerated-phase CML (AP-CML) harboring the T315I mutation and in adult patients with CP-CML resistant to and/or intolerant of first- and second-generation TKIs. \n\n\"We are thrilled to enter into this agreement with Takeda, which would allow us to leverage the global commercial expertise of an organization with a proven track record and global oncology footprint to potentially broaden the impact olverembatinib could have on patients in need around the world,” said Dr. Dajun Yang, Chairman and CEO of Ascentage Pharma. “We have seen the impact olverembatinib has had on patients with CML in China and look forward to progressing development of olverembatinib in POLARIS-2, the global registrational Phase 3 study in previously treated adult patients with CP-CML with or without the T315I mutation.” \n\nUnder the terms of this agreement, Ascentage Pharma will receive an option payment of $100 million upon signing of the exclusive option to license agreement and will be eligible for an option exercise fee and additional potential milestone and royalty payments if Takeda exercises the option to license olverembatinib, with the exercise of the option being subject to customary regulatory approvals. Additionally, Ascentage Pharma will receive a minority equity investment from Takeda. \n\n## About Olverembatinib\n\nOlverembatinib is an oral, third-generation BCR-ABL tyrosine kinase inhibitor (TKI). Olverembatinib is currently approved and marketed in China for the treatment of adult patients with TKI-resistant chronic-phase chronic myeloid leukemia (CP-CML) or accelerated-phase CML (AP-CML) harboring the T315I mutation and in adult patients with CP-CML resistant to and/or intolerant of first- and second-generation TKIs. Ascentage Pharma is investigating olverembatinib in multiple clinical studies in several types of cancer. Olverembatinib has been granted orphan drug designation and Fast Track designation by the U.S. Food and Drug Administration (FDA) and orphan designation by the European Medicines Agency (EMA).\n\n## About Takeda \n\nTakeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R\u0026D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit [www.takeda.com](https://www.takeda.com/). \n\n\n## Media Contacts:\n\n### Japanese Media\n\nJun Saito\n\n[jun.saito@takeda.com](mailto:jun.saito@takeda.com) \n\n### U.S. and International Media\n\nJennifer Anderson\n\n[jennifer.anderson@takeda.com](mailto:jennifer.anderson@takeda.com)\n\n## Important Notice\n\nFor the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.\n\nThe companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.\n\n## Forward-Looking Statements\n\nThis press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: [https://www.takeda.com/investors/sec-filings-and-security-reports/](https://www.takeda.com/investors/sec-filings-and-security-reports/) or at [www.sec.gov](https://www.sec.gov/). Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.\n\n## Medical Information\n\nThis press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.","slug":"/news/news-releases/takeda-signs-option-agreement-with-ascentage-pharma-to-enter-into-exclusive-global-license-for-olverembatinib","__metadata":{"modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"62053b40-ee66-4367-8e03-532e74d9570c","createdAt":"2024-06-13T19:48:18Z","updatedAt":"2024-06-14T11:54:59Z"},"type":"Article","featuredImg":{"created_at":"2023-01-31T18:17:13Z","_version":1,"url":"http://assets-dam.takeda.com/image/upload/v1675189033/legacy-dotcom/siteassets/ja-jp/home/takeda_logo.svg","format":"svg","resource_type":"image","created_by":{"id":"553579438111562","type":"accesskey"},"folder_id":"c190ec1e8b89091d82749269dcc568ea96","bytes":3685,"height":599,"metadata":{"epzciwdjuelllku8ngpo":["0001"]},"version":1675189033,"uploaded_by":{"id":"553579438111562","type":"accesskey"},"id":"b75fe16a3c7b8a0b4a272117d2e669af","type":"cloudinary.asset","width":1080,"secure_url":"https://assets-dam.takeda.com/image/upload/v1675189033/legacy-dotcom/siteassets/ja-jp/home/takeda_logo.svg","public_id":"legacy-dotcom/siteassets/ja-jp/home/takeda_logo","access_mode":"public","__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}},{"description":"Takeda and Pfizer Announce Four-Year Results from Positive Phase 3 HD21 Trial of ADCETRIS Combination in Frontline Hodgkin Lymphoma. Presented at ASCO/EHA.","visibleInListings":true,"slug":"/news/news-releases/four-year-results-from-positive-phase-3-hd21-trial","publishDate":"2024-06-01T12:00:00.000Z","content":"* **Four-year Analysis Conducted by GHSG Reported ADCETRIS + ECADD Combination Improved Progression-Free Survival, Showing Superior Efficacy and Tolerable Safety Profile in Patients with Newly Diagnosed Stage IIb/III/IV Classical Hodgkin Lymphoma vs eBEACOPP, a Current Standard of Care in This Setting in Europe**\n* **The HD21 Study Adds to the Body of Evidence Supporting ADCETRIS as a Backbone Agent in the Treatment of Specific Lymphomas**\n* **Results To Be Featured as Oral Presentations at ASCO and EHA 2024**\n\n**OSAKA, Japan, CAMBRIDGE, Mass., and NEW YORK, June 1, 2024** – Takeda ([TSE:4502/NYSE:TAK](https://www.takeda.com/investors/)) and Pfizer ([NYSE: PFE](https://www.pfizer.com/)) today announced that the German Hodgkin Study Group (GHSG) will present positive results from the Phase 3 HD21 trial evaluating ADCETRIS\u003csup\u003e®\u003c/sup\u003e (brentuximab vedotin) in combination with chemotherapy as a late-breaking oral presentation at the 60\u003csup\u003eth\u003c/sup\u003e American Society of Clinical Oncology (ASCO) Annual Meeting (LBA7000) and at the 29\u003csup\u003eth\u003c/sup\u003e European Hematology Association (EHA) Annual Meeting (S225). The four-year analysis presented by the GHSG showed superior progression-free survival (PFS) and improved tolerability for patients compared to a current standard of care regimen used in Europe in this setting.\n\nThe HD21 study is a Phase 3, randomized, multi-country, prospective, open-label study sponsored by the GHSG and supported by Takeda, designed to evaluate ADCETRIS in combination with etoposide, cyclophosphamide, doxorubicin, dacarbazine and dexamethasone (BrECADD) in comparison to a standard of care treatment – escalated doses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone (eBEACOPP) – in patients with newly diagnosed Stage IIb/III/IV classical Hodgkin lymphoma. At a preplanned three-year analysis, the study met its co-primary endpoints, with the ADCETRIS combination regimen demonstrating significantly improved safety as assessed by treatment-related morbidity (TRMB) and non-inferior PFS.\n\nThe study found that the addition of ADCETRIS to this chemotherapy regimen improved the risk-to-benefit profile of the combination treatment, maintaining efficacy with significantly fewer acute and long-lasting treatment-related toxicities than the comparator arm.\n\n“We initiated the HD21 trial with the hope of improving outcomes currently being achieved by a standard of care, as many patients with newly diagnosed disease often experience a high treatment burden,” said Peter Borchmann, MD, PhD, University Hospital of Cologne, Germany, and trial chairman of the HD21 study. “The presented analysis, in which the ADCETRIS regimen demonstrates superior progression-free survival, as well as a tolerable safety profile, reveals the meaningful potential this ADCETRIS + ECADD regimen has to offer these patients.”\n\nThe ASCO presentation provides details of a four-year PFS analysis of the HD21 study conducted by GHSG. After 48 months, BrECADD showed superior efficacy to BEACOPP (94.3% PFS for BrECADD and 90.9% PFS for eBEACOPP; hazard ratio \"HR\": 0.66 [95% CI:88.7-93.1]; p\u003c0.035). As previously reported in the three-year analysis, treatment with BrECADD was also associated with a significant reduction in the incidence of treatment-related morbidity (TRMB) compared with BEACOPP (n=738; 42% vs 59%; p\u003c0.001), as well as clinically meaningful reductions in adverse events (AEs). The safety profile of ADCETRIS in patients receiving BrECADD remained consistent with other approved ADCETRIS combination regimens, and no new safety signals were identified.\n\n“In our ongoing effort to improve outcomes for patients with lymphoma, we’ve partnered with the GHSG on the HD21 study to deepen our understanding of how ADCETRIS could further benefit patients in need of new options,” said Awny Farajallah, chief medical officer, global oncology at Takeda. “We are excited about the impact these results could have on patients with newly diagnosed Hodgkin lymphoma, potentially bringing them an additional ADCETRIS-based combination regimen that may significantly reduce side effects, without compromising on efficacy.”\n\nTakeda will be responsible for submission of potential regulatory filings based on the HD21 study outside of the U.S. and Canada. Under the terms of the collaboration agreement, Pfizer has U.S. and Canadian commercialization rights and Takeda has rights to commercialize ADCETRIS in the rest of the world.\n\n## About the HD21 Trial\n\nThe HD21 study is a Phase 3, multi-country, prospective, open-label, randomized, multicenter trial sponsored by the German Hodgkin Study Group (GHSG) with a PET-response adapted designed to assess the feasibility, efficacy, safety and tolerability of BrECADD, a novel, rationally designed, CD-30 intensified frontline regimen for patients with advanced classical Hodgkin lymphoma.\n\nEnrolled patients with newly diagnosed, Stage IIb with large mediastinal mass and/or extranodal lesions, stage III or IV Hodgkin lymphoma were randomized to receive two cycles of either escalated BEACOPP or BrECADD, respectively, followed by interim PET staging. A decision is then made if patients received a further two or four cycles of escalated BEACOPP or BrECADD.\n\nThe HD21 trial aims to evaluate a modified treatment regimen to minimize side effects, while maintaining similar responses to treatment. The study has co-primary endpoints: safety is assessed by treatment-related morbidity (TRMB) (superiority), a novel endpoint focused on clinically relevant, acute toxicities of primary chemotherapy, and efficacy is assessed by PFS (non-inferiority). Secondary endpoints are tumor response (complete response [CR] rate), overall survival (OS), infertility rate at one year, second malignancies, frequency of adverse events, therapy adherence, and quality of life.\n\n## About Hodgkin Lymphoma\n\nLymphoma is a general term for a group of cancers that originate in the lymphatic system affecting a type of white blood cell called lymphocytes. There are two major categories of lymphoma: Hodgkin lymphoma (HL) and non-Hodgkin lymphoma. Hodgkin lymphoma is distinguished from other types of lymphoma by the presence of one characteristic type of cell, known as the Reed-Sternberg cell present in lymph nodes. Reed-Sternberg cells usually have a special protein on their surface called CD30, which is a key marker of HL. CD30 is present in approximately 95 percent of all cases of Hodgkin lymphoma.\n\nAccording to the International Agency for Research on Cancer, in 2020, over 83,000 people worldwide were diagnosed with Hodgkin lymphoma and approximately 23,000 people died from this cancer.\n\n## About ADCETRIS® (brentuximab vedotin)\n\nADCETRIS is an antibody-drug conjugate (ADC) comprising an anti-CD30 monoclonal antibody attached by a protease-cleavable linker to a microtubule disrupting agent, monomethyl auristatin E (MMAE), utilizing Pfizer’s proprietary technology. The ADC employs a linker system that is designed to be stable in the bloodstream but to release MMAE upon internalization into CD30-positive tumor cells.\n\nADCETRIS injection for intravenous infusion has received FDA approval for seven indications:\n\n* Adult patients with previously untreated Stage III/IV classical Hodgkin lymphoma (cHL) in combination with doxorubicin, vinblastine, and dacarbazine (2018)\n\n* Pediatric patients 2 years and older with previously untreated high risk cHL in combination with doxorubicin, vincristine, etoposide, prednisone and cyclophosphamide (2022)\n\n* Adult patients with cHL at high risk of relapse or progression as post-autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation (2015)\n\n* Adult patients with cHL after failure of auto-HSCT or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not auto-HSCT candidates (2011)\n\n* Adult patients with previously untreated systemic anaplastic large cell lymphoma (sALCL) or other CD30-expressing peripheral T-cell lymphomas (PTCL), including angioimmunoblastic T-cell lymphoma and PTCL not otherwise specified, in combination with cyclophosphamide, doxorubicin, and prednisone (2018)\n\n* Adult patients with sALCL after failure of at least one prior multi-agent chemotherapy regimen. (2011)\n\n* Adult patients with primary cutaneous anaplastic large cell lymphoma (pcALCL) or CD30-expressing mycosis fungoides (MF) after prior systemic therapy (2017)\n\nHealth Canada granted ADCETRIS approval with conditions for relapsed or refractory Hodgkin lymphoma and sALCL in 2013, and non-conditional approval for post-autologous stem cell transplantation (ASCT) consolidation treatment of Hodgkin lymphoma patients at increased risk of relapse or progression in 2017, adults with pcALCL or CD30-expressing MF who have had prior systemic therapy in 2018, for previously untreated Stage IV Hodgkin lymphoma in combination with doxorubicin, vinblastine, and dacarbazine in 2019, and for previously untreated adult patients with sALCL, peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS) or angioimmunoblastic T-cell lymphoma (AITL), whose tumors express CD30, in combination with cyclophosphamide, doxorubicin, prednisone in 2019.\n\nADCETRIS received conditional marketing authorization from the European Commission in October 2012, and the specific obligations of the conditional marketing authorization were fulfilled in May 2022. The approved indications in the European Union are: (1) for the treatment of adult patients with previously untreated CD30-positive Stage III \u0026 IV Hodgkin lymphoma in combination with doxorubicin, vinblastine and dacarbazine (AVD), (2) for the treatment of adult patients with CD30-positive Hodgkin lymphoma at increased risk of relapse or progression following ASCT, (3) for the treatment of adult patients with relapsed or refractory CD30-positive Hodgkin lymphoma following ASCT, or following at least two prior therapies when ASCT or multi-agent chemotherapy is not a treatment option, (4) for the treatment of adult patients with relapsed or refractory sALCL, (5) for the treatment of adult patients with previously untreated sALCL in combination with CHP and (6) for the treatment of adult patients with CD30-positive cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.\n\nADCETRIS has received marketing authorization by regulatory authorities in more than 70 countries for relapsed or refractory Hodgkin lymphoma and sALCL. See Important Safety Information below.\n\nADCETRIS is being evaluated broadly in more than 70 clinical trials, including a Phase 3 study in first-line Hodgkin lymphoma (ECHELON-1) and another Phase 3 study in first-line CD30-positive peripheral T-cell lymphomas (ECHELON-2), as well as trials in many additional types of CD30-positive malignancies.\n\nPfizer and Takeda fund joint development costs for ADCETRIS on a 50:50 basis, except in Japan where Takeda is solely responsible for development costs.\n\n### ADCETRIS (brentuximab vedotin) Important Safety Information (European Union)\n\nPlease refer to Summary of Product Characteristics (SmPC) before prescribing.\n\n#### Contraindications\n\nADCETRIS is contraindicated for patients with hypersensitivity to brentuximab vedotin and its excipients. In addition, combined use of ADCETRIS with bleomycin causes pulmonary toxicity.\n\n#### Special Warnings and Precautions\n\nProgressive multifocal leukoencephalopathy (PML): John Cunningham virus (JCV) reactivation resulting in progressive multifocal leukoencephalopathy (PML) and death can occur in patients treated with ADCETRIS. PML has been reported in patients who received ADCETRIS after receiving multiple prior chemotherapy regimens. PML is a rare demyelinating disease of the central nervous system that results from reactivation of latent JCV and is often fatal.\n\nClosely monitor patients for new or worsening neurological, cognitive, or behavioral signs or symptoms, which may be suggestive of PML. Suggested evaluation of PML includes neurology consultation, gadolinium-enhanced magnetic resonance imaging of the brain, and cerebrospinal fluid analysis for JCV DNA by polymerase chain reaction or a brain biopsy with evidence of JCV. A negative JCV PCR does not exclude PML. Additional follow-up and evaluation may be warranted if no alternative diagnosis can be established. Hold dosing for any suspected case of PML and permanently discontinue ADCETRIS if a diagnosis of PML is confirmed.\n\nBe alert to PML symptoms that the patient may not notice (e.g., cognitive, neurological, or psychiatric symptoms).\n\n**Pancreatitis:** Acute pancreatitis has been observed in patients treated with ADCETRIS. Fatal outcomes have been reported. Closely monitor patients for new or worsening abdominal pain, which may be suggestive of acute pancreatitis. Patient evaluation may include physical examination, laboratory evaluation for serum amylase and serum lipase, and abdominal imaging, such as ultrasound and other appropriate diagnostic measures. Hold ADCETRIS for any suspected case of acute pancreatitis. ADCETRIS should be discontinued if a diagnosis of acute pancreatitis is confirmed.\n\n**Pulmonary Toxicity:** Cases of pulmonary toxicity, some with fatal outcomes, including pneumonitis, interstitial lung disease, and acute respiratory distress syndrome (ARDS), have been reported in patients receiving ADCETRIS. Although a causal association with ADCETRIS has not been established, the risk of pulmonary toxicity cannot be ruled out. Promptly evaluate and treat new or worsening pulmonary symptoms (e.g., cough, dyspnea) appropriately. Consider holding dosing during evaluation and until symptomatic improvement.\n\n**Serious infections and opportunistic infections:** Serious infections such as pneumonia, staphylococcal bacteremia, sepsis/septic shock (including fatal outcomes), and herpes zoster, cytomegalovirus (CMV) (reactivation) and opportunistic infections such as Pneumocystis jiroveci pneumonia and oral candidiasis have been reported in patients treated with ADCETRIS. Patients should be carefully monitored during treatment for the emergence of possible serious and opportunistic infections.\n\n**Infusion-related reactions (IRR):** Immediate and delayed IRR, as well as anaphylaxis, have been reported with ADCETRIS. Carefully monitor patients during and after an infusion. If anaphylaxis occurs, immediately and permanently discontinue administration of ADCETRIS and administer appropriate medical therapy. If an IRR occurs, interrupt the infusion and institute appropriate medical management. The infusion may be restarted at a slower rate after symptom resolution. Patients who have experienced a prior IRR should be premedicated for subsequent infusions. IRRs are more frequent and more severe in patients with antibodies to ADCETRIS.\n\n**Tumor lysis syndrome (TLS):** TLS has been reported with ADCETRIS. Patients with rapidly proliferating tumor and high tumor burden are at risk of TLS. Monitor these patients closely and manage according to best medical practice.\n\n**Peripheral neuropathy (PN):** ADCETRIS treatment may cause PN, both sensory and motor. ADCETRIS-induced PN is typically an effect of cumulative exposure to ADCETRIS and is reversible in most cases. Monitor patients for symptoms of neuropathy, such as hypoesthesia, hyperesthesia, paresthesia, discomfort, a burning sensation, neuropathic pain, or weakness. Patients experiencing new or worsening PN may require a delay and a dose reduction or discontinuation of ADCETRIS.\n\n**Hematological toxicities:** Grade 3 or Grade 4 anemia, thrombocytopenia, and prolonged (equal to or greater than one week) Grade 3 or Grade 4 neutropenia can occur with ADCETRIS. Monitor complete blood counts prior to administration of each dose.\n\n**Febrile neutropenia:** Febrile neutropenia has been reported with ADCETRIS. Complete blood counts should be monitored prior to administration of each dose of treatment. Closely monitor patients for fever and manage according to best medical practice if febrile neutropenia develops.\n\nWhen ADCETRIS is administered in combination with AVD or CHP, primary prophylaxis with G-CSF is recommended for all patients beginning with the first dose.\n\n**Severe cutaneous adverse reactions (SCARs):** Cases of SCARs, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported with ADCETRIS. Fatal outcomes have been reported for SJS and TEN. If SJS, TEN or DRESS occur, ADCETRIS should be discontinued and appropriate medical therapy should be administered.\n\n**Gastrointestinal (GI) Complications:** GI complications, some with fatal outcomes, including intestinal obstruction, ileus, enterocolitis, neutropenic colitis, erosion, ulcer, perforation and haemorrhage, have been reported with ADCETRIS. Promptly evaluate and treat patients if new or worsening GI symptoms occur.\n\n**Hepatotoxicity:** Elevations in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) have been reported with ADCETRIS. Serious cases of hepatotoxicity, including fatal outcomes, have also occurred. Pre-existing liver disease, comorbidities, and concomitant medications may also increase the risk. Test liver function prior to treatment initiation and routinely monitor during treatment. Patients experiencing hepatotoxicity may require a delay, dose modification, or discontinuation of ADCETRIS.\n\n**Hyperglycemia:** Hyperglycemia has been reported during trials in patients with an elevated body mass index (BMI) with or without a history of diabetes mellitus. Closely monitor serum glucose for patients who experience an event of hyperglycemia. Administer anti-diabetic treatment as appropriate.\n\n**Infusion site extravasation:** Extravasation during intravenous infusion has occurred. Given the possibility of extravasation, it is recommended to closely monitor the infusion site for possible infiltration during drug administration.\n\n**Renal and Hepatic Impairment:** There is limited experience in patients with renal and hepatic impairment. Available data indicate that MMAE clearance might be affected by severe renal impairment, hepatic impairment, and by low serum albumin concentrations.\n\n**CD30+ CTCL:** The size of the treatment effect in CD30 + CTCL subtypes other than mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (pcALCL) is not clear due to lack of high level evidence. In two single arm phase II studies of ADCETRIS, disease activity has been shown in the subtypes Sézary syndrome (SS), lymphomatoid papulosis (LyP) and mixed CTCL histology. These data suggest that efficacy and safety can be extrapolated to other CTCL CD30+ subtypes. Carefully consider the benefit-risk per patient and use with caution in other CD30+ CTCL patient types.\n\n**Sodium content in excipients:** This medicinal product contains 13.2 mg sodium per vial, equivalent to 0.7% of the WHO recommended maximum daily intake of 2 g sodium for an adult.\n\n**Traceability:** In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded.\n\n#### INTERACTIONS\n\nPatients who are receiving a strong CYP3A4 and P-gp inhibitor, concomitantly with ADCETRIS may have an increased risk of neutropenia. If neutropenia develops, refer to dosing recommendations for neutropenia (see SmPC section 4.2). Co-administration of ADCETRIS with a CYP3A4 inducer did not alter the plasma exposure of ADCETRIS, but it appeared to reduce plasma concentrations of MMAE metabolites that could be assayed. ADCETRIS is not expected to alter the exposure to drugs that are metabolized by CYP3A4 enzymes.\n\n**PREGNANCY:** Advise women of childbearing potential to use two methods of effective contraception during treatment with ADCETRIS and until 6 months after treatment. There are no data from the use of ADCETRIS in pregnant women, although studies in animals have shown reproductive toxicity. Do not use ADCETRIS during pregnancy unless the benefit to the mother outweighs the potential risks to the fetus.\n\n**LACTATION (breast-feeding):** There are no data as to whether ADCETRIS or its metabolites are excreted in human milk, therefore a risk to the newborn/infant cannot be excluded. A decision should be made whether to discontinue breast-feeding or to discontinue/abstain from this therapy, taking into account a potential risk of breast-feeding for the child and the benefit of therapy for the woman.\n\n**FERTILITY:** In non-clinical studies, brentuximab vedotin treatment has resulted in testicular toxicity, and may alter\nmale fertility. MMAE has been shown to have anagenic properties. Therefore, men being treated with this medicine are advised to have sperm samples frozen and stored before treatment. Men being treated with this medicine are advised not to father a child during treatment and for up to 6 months following the last dose.\n\nEffects on ability to drive and use machines: ADCETRIS may have a moderate influence on the ability to drive and use machines.\n\n#### UNDESIRABLE EFFECTS\n\n**Monotherapy:** The most frequent adverse reactions (≥10%) were infections, peripheral sensory neuropathy, nausea, fatigue, diarrhea, pyrexia, upper respiratory tract infection, neutropenia, rash, cough, vomiting, arthralgia, peripheral motor neuropathy, infusion-related reactions, pruritus, constipation, dyspnea, weight decreased, myalgia and abdominal pain. Serious adverse drug reactions occurred in 12% of patients. The frequency of unique serious adverse drug reactions was ≤1%. Adverse events led to treatment discontinuation in 24% of patients.\n\n**Combination Therapy:** In the studies of ADCETRIS as combination therapy in 662 patients with previously untreated advanced HL (C25003) and 223 patients with previously untreated CD30+ PTCL, the most common adverse reactions (≥ 10%) were: infections, neutropenia, peripheral sensory neuropathy, nausea, constipation, vomiting, diarrhea, fatigue, pyrexia, alopecia, anemia, weight decreased, stomatitis, febrile neutropenia, abdominal pain, decreased appetite, insomnia, bone pain, rash, cough, dyspnea, arthralgia, myalgia, back pain, peripheral motor neuropathy, upper respiratory tract infection, and dizziness. In patients receiving ADCETRIS combination therapy, serious adverse reactions occurred in 34% of patients. Serious adverse reactions occurring in ≥ 3% of patients included febrile neutropenia (15%), pyrexia (5%), and neutropenia (3%). Adverse events led to treatment discontinuation in 10% of patients.\n\n### ADCETRIS® (brentuximab vedotin) for injection U.S. Important Safety Information\n\n#### BOXED WARNING\n\n**PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML): JC virus infection resulting in PML, and death can occur in ADCETRIS-treated patients.**\n\n#### CONTRAINDICATION\n\nContraindicated with concomitant bleomycin due to pulmonary toxicity (e.g., interstitial infiltration and/or inflammation).\n\n#### WARNINGS AND PRECAUTIONS\n\n**Peripheral neuropathy (PN):** ADCETRIS causes PN that is predominantly sensory. Cases of motor PN have also been reported. ADCETRIS-induced PN is cumulative. Monitor for symptoms such as hypoesthesia, hyperesthesia, paresthesia, discomfort, a burning sensation, neuropathic pain, or weakness. Patients experiencing new or worsening PN may require a delay, change in dose, or discontinuation of ADCETRIS.\n\n**Anaphylaxis and infusion reactions:** Infusion-related reactions (IRR), including anaphylaxis, have occurred with ADCETRIS. Monitor patients during infusion. If an IRR occurs, interrupt the infusion and institute appropriate medical management. If anaphylaxis occurs, immediately and permanently discontinue the infusion and administer appropriate medical therapy. Premedicate patients with a prior IRR before subsequent infusions. Premedication may include acetaminophen, an antihistamine, and a corticosteroid.\n\n**Hematologic toxicities:** Fatal and serious cases of febrile neutropenia have been reported with ADCETRIS. Prolonged (≥1 week) severe neutropenia and Grade 3 or 4 thrombocytopenia or anemia can occur with ADCETRIS.\n\nAdminister G-CSF primary prophylaxis beginning with Cycle 1 for adult patients who receive ADCETRIS in combination with chemotherapy for previously untreated Stage III/IV cHL or previously untreated PTCL, and pediatric patients who receive ADCETRIS in combination with chemotherapy for previously untreated high risk cHL.\n\nMonitor complete blood counts prior to each ADCETRIS dose. Monitor more frequently for patients with Grade 3 or 4 neutropenia. Monitor patients for fever. If Grade 3 or 4 neutropenia develops, consider dose delays, reductions, discontinuation, or G-CSF prophylaxis with subsequent doses.\n\n**Serious infections and opportunistic infections:** Infections such as pneumonia, bacteremia, and sepsis or septic shock (including fatal outcomes) have been reported in ADCETRIS-treated patients. Closely monitor patients during treatment for infections.\n\n**Tumor lysis syndrome:** Patients with rapidly proliferating tumor and high tumor burden may be at increased risk. Monitor closely and take appropriate measures.\n\n**Increased toxicity in the presence of severe renal impairment:** The frequency of ≥Grade 3 adverse reactions and deaths was greater in patients with severe renal impairment. Avoid use in patients with severe renal impairment.\n\n**Increased toxicity in the presence of moderate or severe hepatic impairment:** The frequency of ≥Grade 3 adverse reactions and deaths was greater in patients with moderate or severe hepatic impairment. Avoid use in patients with moderate or severe hepatic impairment.\n\n**Hepatotoxicity:** Fatal and serious cases have occurred in ADCETRIS-treated patients. Cases were consistent with hepatocellular injury, including elevations of transaminases and/or bilirubin, and occurred after the first ADCETRIS dose or rechallenge. Preexisting liver disease, elevated baseline liver enzymes, and concomitant medications may increase the risk. Monitor liver enzymes and bilirubin. Patients with new, worsening, or recurrent hepatotoxicity may require a delay, change in dose, or discontinuation of ADCETRIS.\n\n**PML:** Fatal cases of JC virus infection resulting in PML have been reported in ADCETRIS-treated patients. First onset of symptoms occurred at various times from initiation of ADCETRIS, with some cases occurring within 3 months of initial exposure. In addition to ADCETRIS therapy, other possible contributory factors include prior therapies and underlying disease that may cause immunosuppression. Consider PML diagnosis in patients with new-onset signs and symptoms of central nervous system abnormalities. Hold ADCETRIS if PML is suspected and discontinue ADCETRIS if PML is confirmed.\n\n**Pulmonary toxicity:** Fatal and serious events of noninfectious pulmonary toxicity, including pneumonitis, interstitial lung disease, and acute respiratory distress syndrome, have been reported. Monitor patients for signs and symptoms, including cough and dyspnea. In the event of new or worsening pulmonary symptoms, hold ADCETRIS dosing during evaluation and until symptomatic improvement.\n\n**Serious dermatologic reactions:** Fatal and serious cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported with ADCETRIS. If SJS or TEN occurs, discontinue ADCETRIS and administer appropriate medical therapy.\n\n**Gastrointestinal (GI) complications:** Fatal and serious cases of acute pancreatitis have been reported. Other fatal and serious GI complications include perforation, hemorrhage, erosion, ulcer, intestinal obstruction, enterocolitis, neutropenic colitis, and ileus. Lymphoma with pre-existing GI involvement may increase the risk of perforation. In the event of new or worsening GI symptoms, including severe abdominal pain, perform a prompt diagnostic evaluation and treat appropriately.\n\n**Hyperglycemia:** Serious cases, such as new-onset hyperglycemia, exacerbation of pre-existing diabetes mellitus, and ketoacidosis (including fatal outcomes) have been reported with ADCETRIS. Hyperglycemia occurred more frequently in patients with high body mass index or diabetes. Monitor serum glucose and if hyperglycemia develops, administer anti-hyperglycemic medications as clinically indicated.\n\n**Embryo-fetal toxicity:** Based on the mechanism of action and animal studies, ADCETRIS can cause fetal harm. Advise females of reproductive potential of this potential risk, and to use effective contraception during ADCETRIS treatment and for 2 months after the last dose of ADCETRIS. Advise male patients with female partners of reproductive potential to use effective contraception during ADCETRIS treatment and for 4 months after the last dose of ADCETRIS.\n\n#### ADVERSE REACTIONS\n\nThe most common adverse reactions (≥20% in any study) are peripheral neuropathy, fatigue, nausea, diarrhea, neutropenia, upper respiratory tract infection, pyrexia, constipation, vomiting, alopecia, decreased weight, abdominal pain, anemia, stomatitis, lymphopenia, mucositis, thrombocytopenia, and febrile neutropenia.\n\n#### DRUG INTERACTIONS\n\nConcomitant use of strong CYP3A4 inhibitors has the potential to affect the exposure to monomethyl auristatin E (MMAE). Closely monitor adverse reactions.\n\n#### USE IN SPECIAL POPULATIONS\n\n**Lactation:** Breastfeeding is not recommended during ADCETRIS treatment.\n\n\u003cbr\u003e\n\n**Please see the full Prescribing Information, including BOXED WARNING, for ADCETRIS** [**here**](https://seagendocs.com/Adcetris_Full_Ltr_Master.pdf)**.**\n\n\u003cbr\u003e\n\n## About Takeda\n\nTakeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R\u0026D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com.\n\n## About Pfizer: Breakthroughs That Change Patients’ Lives\n\nAt Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety, and value in the discovery, development, and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments, and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments, and local communities to support and expand access to reliable, affordable health care around the world. For 175 years, we have worked to make a difference for all who rely on us. We routinely post information that may be important to investors on our website at [www.pfizer.com](http://www.pfizer.com/). In addition, to learn more, please visit us on [www.pfizer.com](http://www.pfizer.com/) and follow us on X at [@Pfizer](https://twitter.com/pfizer) and [@Pfizer\\_News](https://twitter.com/pfizer_news), [LinkedIn](https://www.linkedin.com/company/pfizer), [YouTube](https://www.youtube.com/c/pfizer) and like us on Facebook at [Facebook.com/Pfizer](https://www.facebook.com/Pfizer/).\n\n### Takeda Media Contacts:\n\n#### Japanese Media\n\nJun Saito\n\n[jun.saito@takeda.com](mailto:jun.saito@takeda.com)\n\n+81 (0) 3-3278-2325\n\n#### U.S. and International Media\n\nEmy Gruppo\n\n[emy.gruppo@takeda.com](mailto:emy.gruppo@takeda.com)\n\n+1 667-444-2252\n\n#### Pfizer Contacts:\n\nMedia\n\n+1 (212) 733-1226\n\n[PfizerMediaRelations@pfizer.com](mailto:PfizerMediaRelations@pfizer.com)\n\nInvestor Relations\n\n+1 (212) 733-4848\n\n[IR@pfizer.com](mailto:IR@pfizer.com)\n\n## Important Notice\n\nFor the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws. The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.\n\n## Takeda Forward-Looking Statements\n\nThis press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could” “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings-and-security-reports/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.\n\n## Medical information\n\nThis press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.\n\n## Pfizer Disclosure Notice:\n\nThe information contained in this release is as of June 1, 2024. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.\n\nThis release contains forward-looking information about ADCETRIS (brentuximab vedotin), including its potential benefits, its potential in newly diagnosed Stage IIb/III/IV Hodgkin lymphoma, and potential regulatory filings, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, uncertainties regarding the commercial success of ADCETRIS; the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for our clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when drug applications may be filed in particular jurisdictions for ADCETRIS with eCADD or as a single agent for any potential indication; whether and when any applications that may be pending or filed for ADCETRIS, may be approved by regulatory authorities, which will depend on myriad factors, including making a determination as to whether the product's benefits outweigh its known risks and determination of the product's efficacy and, if approved, whether ADCETRIS with eCADD or as a single agent will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of ADCETRIS; uncertainties regarding the impact of COVID-19 on Pfizer’s business, operations and financial results; and competitive developments.\n\nA further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 and in its subsequent reports on Form 10-Q, including in the sections thereof captioned “Risk Factors” and “Forward-Looking Information and Factors That May Affect Future Results”, as well as in its subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission and available at[ www.sec.gov](https://cts.businesswire.com/ct/CT?id=smartlink\\\u0026url=http%3A%2F%2Fwww.sec.gov%2F\\\u0026esheet=53891413\\\u0026newsitemid=20240202234166\\\u0026lan=en-US\\\u0026anchor=www.sec.gov\\\u0026index=9\\\u0026md5=2944f07ea5b4c3ed3594656685fe5ef6) and [www.pfizer.com](https://cts.businesswire.com/ct/CT?id=smartlink\\\u0026url=http%3A%2F%2Fwww.pfizer.com%2F\\\u0026esheet=53891413\\\u0026newsitemid=20240202234166\\\u0026lan=en-US\\\u0026anchor=www.pfizer.com\\\u0026index=10\\\u0026md5=98d8d99a18306c2e5f2d33d9ffb5ca80).\n\n","title":"Takeda and Pfizer Announce Four-Year Results from Positive Phase 3 HD21 Trial of Additional ADCETRIS® (brentuximab vedotin) Combination in Frontline Hodgkin Lymphoma","taxonomies":[{"displayName":"News 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Awny Farajallah, M.D., Chief Medical Officer, Global Oncology Business Unit**\n\nOver the past several decades, the rapid pace of scientific advancement has catalyzed a revolution in the way we treat cancers. This has led to a stronger focus on survival outcomes, and, in some cancers, many patients are living longer on treatment than ever before thanks to therapeutic developments such as novel targeted therapies and immunotherapy. The improvement in survival rates has created an opportunity – and obligation – to consider factors beyond just survival rates when it comes to the management of the disease.\n\nAs we continue to advance treatment options, there has been a growing movement towards prioritizing patient-centered care – considering the individual health status, preferences, values, and goals of patients when making treatment decisions. Balancing clinical outcomes with the real-world experiences of patients can be complex but is necessary to provide the best possible care. \n\n## Redefining Survival: The Dramatic Impact of Targeted Therapy\n\nLet’s dive a little deeper into one of the reasons we’ve observed such notable improvements in the survival rates for certain cancer types – targeted therapies. Targeted therapies have revolutionized the way some cancers are treated by enabling us to target a genetic mutation that may be driving the cancer. This scientific achievement has dramatically changed the prognosis for certain types of cancers, such as breast and lung.\n\nFor example, breast cancer is the second-most common and lethal cancer type in women, and treatment options were previously limited to chemotherapies, radiation, and surgical procedures. For HER2-positive breast cancers specifically, which account for about 20% of all breast cancers, the disease is more aggressive and has a worse prognosis. The development of HER2-targeted drugs has forever changed the treatment approach and patient outcomes. In fact, some treatment combinations for this cancer extend survival to more than 4.5 years, compared to a life expectancy of 1.5 years achieved 14 years ago.\u003csup\u003e1\u003c/sup\u003e\n\nA similar transformation has occurred in the treatment of non-small cell lung cancer (NSCLC), another widespread cancer that has been historically difficult to treat and was previously treated with chemotherapy, radiotherapy or a combination of both. Over time, we’ve learned that about 70% of patients with NSCLC have a targetable mutation, such as EGFR, BRAF, ALK or KRAS. With improved diagnostic testing, these patients are being matched with treatments that target their cancer at its source. As a result, in recent years, population-level mortality from NSCLC has fallen sharply.\u003csup\u003e2\u003c/sup\u003e\n\nIn addition to longer survival durations, some targeted therapies have also improved upon the toxicity profiles and administration of standard chemotherapies. For example, in a study comparing neoadjuvant targeted therapy versus neoadjuvant chemotherapy in advanced-stage EGFR-mutant NSCLC, the incidence of grade 3/4 adverse events was found to be significantly less in the targeted therapy group compared to the chemotherapy group.\u003csup\u003e3\u003c/sup\u003e Many of these targeted therapies are administered orally, providing a more convenient dosing regimen for patients.\u003csup\u003e4-10\u003c/sup\u003e \n\nIn the 20+ years since the first targeted therapies for cancer were introduced, they have revolutionized the diagnosis and treatment of patients with breast cancer, lung cancer and many other types of cancer, and made the possibility of extending patients’ lives while improving convenience, adherence and safety, a reality.\u003csup\u003e11\u003c/sup\u003e \n\n## From Survival to Survivorship \n\nWhile the rise in survival rates is an incredible accomplishment that will continue to be built upon as science advances, it has also brought about a paradigm shift in cancer care. With more cancer survivors living longer and more therapeutic options than ever before, there is greater impetus to evolve how we evaluate factors to identify the best treatment for each patient. \n\nFor example, quality of life (QoL) and method of treatment administration are important real-world factors that should be considered in addition to clinical outcomes, as they play a crucial role in the everyday lives and experiences of patients. \n\nThat said, how they are viewed and prioritized can differ by patient. For example, some patients may prioritize convenience and flexibility in treatment administration, while others may be more concerned about potential side effects or the impact of treatment on their ability to work or socialize. Some patients may prefer oral therapies that can be taken at home, while others may be comfortable with intravenous therapies administered in a clinical setting.\n\nEvaluating these factors alongside traditional clinical standards when determining the best possible treatment ensures we are taking not only a patient’s survival into account – but also their quality of survivorship. Survivorship, in the context of cancer, refers to the journey and life experiences patients must navigate following their cancer diagnosis. Despite advancements in care over the past decade, there are still substantial gaps and challenges that need to be addressed to alleviate the short- and long-term effects of treatments – such as fatigue, cognitive problems, and pain – and their impact on an individual’s survivorship and long-term disease management. \n\nBecause real-world factors and their role in survivorship are often not measured in randomized clinical trials, it’s crucial we invest in real-world evidence research and partner with patients and advocacy groups to understand how patients experience and prioritize factors such as location, family type, socioeconomic status, mental health, support systems, and cultural background and how these considerations influence their decisions.\n\nUltimately, the goal is to provide patients with the best possible opportunity of achieving long-term survival while also maintaining a good quality of life. This requires a collaborative effort between patients, their healthcare providers, and the healthcare industry to ensure that the unique needs and preferences of each patient are considered to improve care. \n\n## Looking Ahead\n\nWhile clinical outcomes will continue to be paramount, as treatment options improve, it is imperative that additional factors are considered, and patients are actively involved in the decision-making process. Considering patient preferences on factors like quality of life, treatment feasibility and emotional well-being alongside considerations on clinical efficacy can help optimize outcomes and patient experience. \n\nBy prioritizing an environment of trust, shared decision-making, and open communication, we can empower individuals to actively participate in their treatment journeys and become informed partners in their own care, which has been shown to improve their perception of quality of care and conversations with physicians.\u003csup\u003e12\u003c/sup\u003e\n\nThe future of cancer treatment lies in embracing an approach that considers a complete picture of patient health, recognizing not only survival as a key outcome but also incorporating the patient's overall well-being, or survivorship. By integrating real-world factors into treatment decision-making, prioritizing patient-centered care, and fostering ongoing research, we can collectively transform the cancer survivorship landscape and, hopefully, empower individuals worldwide to lead fulfilling lives beyond their diagnosis.\n\n## References\n\n1. Mendes D, Alves C, Afonso N, et al. The benefit of HER2-targeted therapies on overall survival of patients with metastatic HER2-positive breast cancer – a systematic review. Breast Cancer Res 17, 140 (2015). https://doi.org/10.1186/s13058-015-0648-2\n2. Howlader H, Forjaz G, Mooradian M, et al. The Effect of Advances in Lung-Cancer Treatment on Population Mortality. N Engl J Med 2020;383:640-649. Published 2020 Aug 12. DOI: 10.1056/NEJMoa1916623\n3. Chen D, Jin Z, Zhang J, et al. Efficacy and Safety of Neoadjuvant Targeted Therapy vs. Neoadjuvant Chemotherapy for Stage IIIA EGFR-Mutant Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis. Front Surg. 2021;8:715318. Published 2021 Aug 19. doi:10.3389/fsurg.2021.715318\n4. Assoun S, Lemiale V, Azoulay E. Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases. Intensive Care Med. 2019;45(7):988-997. doi:10.1007/s00134-019-05650-w\n5. Atrium Health. Treating Stage IV Lung Cancer With a Pill. Available at: https://atriumhealth.org/dailydose/2018/01/10/treating-stage-iv-lung-cancer-with-a-pill\n6. XALKORI Prescribing Information. Pfizer. Available at: https://labeling.pfizer.com/ShowLabeling.aspx?id=676\n7. ZYKADIA Prescribing Information. Novartis. Available at: https://www.novartis.com/us-en/sites/novartis_us/files/zykadia.pdf\n8. ALECENSA Prescribing Information. Genentech. Available at: https://www.gene.com/download/pdf/alecensa_prescribing.pdf\n9. LORBRENA Prescribing Information. Pfizer. Available at: https://labeling.pfizer.com/ShowLabeling.aspx?id=11140\n10. ALUNBRIG Prescribinig Information. Takeda. Available at: https://www.alunbrig.com/sites/default/files/2022-10/prescribing-information.pdf\n11. American Cancer Society. History of Cancer Treatments: Targeted Therapy. Available at: https://www.cancer.org/cancer/understanding-cancer/history-of-cancer/cancer-treatment-targeted-therapy.html\n12. Kehl KL, Landrum MB, Arora NK, et al. Association of Actual and Preferred Decision Roles With Patient-Reported Quality of Care: Shared Decision Making in Cancer Care. JAMA Oncol. 2015;1(1):50–58. doi:10.1001/jamaoncol.2014.112\n","publishDate":"2024-05-29T15:26:00.000Z","title":"Living is More Than Surviving: Balancing Clinical Outcomes with Patient Impact","description":"Over the past several decades, the rapid pace of scientific advancement has catalyzed a revolution in the way we treat cancers. Takeda Oncology │ Leadership │ Article","slug":"/news/our-viewpoints/living-is-more-than-surviving","visibleInListings":true,"featuredImg":{"created_at":"2024-05-29T14:11:56Z","format":"png","version":1716991916,"url":"http://assets-dam.takeda.com/image/upload/v1716991916/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More.png","created_by":{"id":"553579438111562","type":"accesskey"},"width":1280,"type":"cloudinary.asset","folder":"Takeda Oncology/News/our-viewpoints","height":720,"folder_id":"c1e80517a809460d7004a5152963235b6c","bytes":76242,"uploaded_by":{"id":"553579438111562","type":"accesskey"},"metadata":{"epzciwdjuelllku8ngpo":["0001"]},"resource_type":"image","access_mode":"public","public_id":"Takeda Oncology/News/our-viewpoints/16x9_Living-Is-More","_version":1,"secure_url":"https://assets-dam.takeda.com/image/upload/v1716991916/Takeda%20Oncology/News/our-viewpoints/16x9_Living-Is-More.png","id":"b9e27c6a7a072900e001199adc6a191d","__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}},"__metadata":{"modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"3066293e-640b-498f-8a53-9e8c9d50ea81","createdAt":"2024-05-27T16:45:47Z","updatedAt":"2024-05-29T23:07:29Z"},"type":"Article"},{"slug":"/news/our-viewpoints/beyond-early-detection-bridging-the-gaps-in-metastatic-colorectal-cancer-support","description":"Beyond early detection, how do we bridge the gap in metastatic colorectal cancer care. Learn about Takeda’s partnerships for patient support.","title":"Beyond Early Detection: Bridging the Gaps in Metastatic Colorectal Cancer Support","visibleInListings":true,"publishDate":"2024-02-29T15:26:00.000Z","featuredImg":{"version":1709145929,"url":"http://assets-dam.takeda.com/image/upload/v1709145929/Takeda%20Oncology/News/our-viewpoints/Beyond%20Early%20Detection.png","height":1080,"created_at":"2024-02-28T18:45:29Z","public_id":"Takeda Oncology/News/our-viewpoints/Beyond Early Detection","format":"png","width":1920,"resource_type":"image","secure_url":"https://assets-dam.takeda.com/image/upload/v1709145929/Takeda%20Oncology/News/our-viewpoints/Beyond%20Early%20Detection.png","access_mode":"public","_version":1,"type":"cloudinary.asset","bytes":191085,"uploaded_by":{"id":"ec6a5b13a6920997f0770195fabdbb","type":"user"},"folder_id":"c1e80517a809460d7004a5152963235b6c","created_by":{"id":"ec6a5b13a6920997f0770195fabdbb","type":"user"},"id":"632cf2e2b734b8b7a06bbe65939ad58a","metadata":{"epzciwdjuelllku8ngpo":["0001"]},"__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}},"content":"In the United States, colorectal cancer (CRC) is the third leading cause of cancer-related deaths, with a projected toll of over 50,000 deaths in 2024. Overall, the lifetime risk of developing CRC is about 1 in 23 for men and 1 in 25 for women.\u003csup\u003e1\u003c/sup\u003e\n\nWhen people are diagnosed with later stage or more advanced CRC, it is known as metastatic CRC (mCRC).\u003csup\u003e2\u003c/sup\u003e When a cancer metastasizes, it means that cancer cells have spread to other parts of the body.\u003csup\u003e3\u003c/sup\u003e When caught early, CRC is often treatable and, in many cases, curable, speaking to the importance of screening and early detection. However, at least 20% of people are diagnosed with CRC in the metastatic stage, and about 50% of people diagnosed with localized CRC will develop metastases over the course of their disease.\u003csup\u003e4,5\u003c/sup\u003e After cancer metastasizes, treatment can become much more challenging and as a result, many people experience diminished survival outcomes and quality of life.\u003csup\u003e6\u003c/sup\u003e\n\n## A Prevalent Cancer, A Lack of Support\n\nWhile CRC ranks among the most prevalent types of cancers, there are still considerable gaps in care and resources for patients, particularly for those experiencing structural challenges and barriers that impact both treatment access and survival outcomes.\n\nThe distribution of CRC and mCRC is not even across U.S. subpopulations; there is a marked difference in incidence among different racial and ethnic groups. For example, Black Americans are about 20% more likely to get CRC and about 40% more likely to die from it than any other racial group in the U.S.\u003csup\u003e7\u003c/sup\u003e Additional factors that could impact disease experience with CRC are socioeconomic status, insurance access, geography and environmental exposure, among others.\n\n\u003e There is a wealth of information available around screening and prevention of CRC, but educational resources are sparse by comparison for patients with advanced CRC. While early detection of CRC is the hope, the unfortunate truth is that many people are either diagnosed with advanced CRC or will progress to it over time. Recognizing the challenges and diverse experience of those with mCRC is not widely documented. There is a critical need to develop comprehensive resources to assist the broader community in providing better support, particularly as new treatment options and combinations emerge, offering people more decisions to navigate.\n\u003e\n\u003e **ASHLEY CALABRESE**\n\u003e Associate Director, Policy and Advocacy, US Public Affairs\n\n## A United Purpose to Support Advanced CRC Patients\n\nJoined by a passion to make a difference for advanced CRC patients, Takeda and four leading advocacy organizations are launching a U.S. survey to identify the most pressing needs concerning disease and treatment navigation. Through this collaborative effort, we intend to uncover actionable insights that will help guide the collective development of resources and education to support patients. Our partners include:\n\n**Colorectal Cancer Alliance:** Founded 25 years ago by more than 40 CRC survivors, caregivers and friends, the Alliance advocates for screening, magnifies patient support and accelerates research. It exists to end CRC in our lifetime.\n\n**COLONTOWN:** Founded by a CRC survivor looking to create a disease-specific community, COLONTOWN empowers proactive colorectal cancer patients and caregivers with educational tools and relevant peer-to-peer support.\n\n**BLKHLTH:** BLKHLTH is an Atlanta-based non-profit with a mission to advance the health of Black communities through equity-centered education, advocacy, research and programs.\n\n**Family Reach:** Family Reach is a non-profit that provides non-medical financial support to people facing cancer. They work with patients, providers and community organizations to challenge the systems that force families to choose between their health and their home.\n\nWe will be unveiling findings for the survey throughout 2024. To learn more about our partners we are collaborating with, please visit their channels: [Colorectal Cancer Alliance](https://colorectalcancer.org/), [COLONTOWN](https://colontown.org/), [BLKHLTH](https://www.blkhlth.com/) and [Family Reach](https://familyreach.org/).\n\n## References\n\n1. American Cancer Society. Key Statistics for Colorectal Cancer. Available at: \u003chttps://www.cancer.org/cancer/types/colon-rectal-cancer/about/key-statistics.html\u003e\n\n2. Memorial Sloan Kettering Cancer Center. Treatment for Metastatic Colon Cancer. Available at: \u003chttps://www.mskcc.org/cancer-care/types/colon/treatment/metastases\u003e\n\n3. City of Hope Cancer Treatment Centers. Metastatic Colorectal Cancer (stage 4). Available at: \u003chttps://www.cancercenter.com/cancer-types/colorectal-cancer/types/metastatic-colorectal-cancer\u003e\n\n4. Biller LH, Schrag D. Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA. 2021;325(7):669-685. doi:10.1001/jama.2021.0106\n\n5. Atreya CE, Yaeger R, Chu E. Systemic therapy for metastatic colorectal cancer: from current standards to future molecular targeted approaches. Am Soc Clin Oncol Educ Book. 2017;37:246-256. doi:10.1200/EDBK_175679\n\n6. American Cancer Society. Treatment of colon cancer, by stage. Available at: \u003chttps://www.cancer.org/cancer/types/colon-rectal-cancer/treating/by-stage-colon.html\u003e\n\n7. American Cancer Society. Colorectal Cancer Rates Higher in African Americans, Rising in Younger People. Available at: \u003chttps://www.cancer.org/cancer/latest-news/colorectal-cancer-rates-higher-in-african-americans-rising-in-younger-people.html\u003e\n\n\n","taxonomies":[{"displayName":"Patients","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"5AQ1D5ZjReEmtg97GZdhmX","createdAt":"2022-10-26T16:28:23Z","updatedAt":"2023-06-08T11:31:34Z"},"type":"Taxonomy"},{"displayName":"our-viewpoints","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"E13B866B-3078-4828-ACC7-6843A32C1074","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:45Z"},"type":"Taxonomy"}],"__metadata":{"modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"acdf9dee-3ade-4000-b599-0028348e1d7f","createdAt":"2024-02-29T19:04:10Z","updatedAt":"2024-09-09T18:17:22Z"},"type":"Article"},{"taxonomies":[{"displayName":"Data and Digital","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"j1tWZCfjdAwUaXU7wUc134","createdAt":"2022-12-16T17:49:34Z","updatedAt":"2023-06-08T11:32:09Z"},"type":"Taxonomy"},{"displayName":"our-viewpoints","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"E13B866B-3078-4828-ACC7-6843A32C1074","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:45Z"},"type":"Taxonomy"}],"authors":[{"additionalInformation":"President, Global Oncology Business Unit","role":"President","fullName":"Teresa Bitetti","__metadata":{"modelName":"Person","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"E0EC499F0BCF","createdAt":"2022-12-12T06:39:01Z","updatedAt":"2023-06-08T11:31:45Z"},"type":"Person"}],"description":"Technological advances continue to push the boundaries of what's possible. Takeda's Teresa Bitetti discusses how we are leveraging these tools for cancer patients.","readTime":0,"title":" Embracing AI \u0026 Emerging Technologies to Advance Cancer Care","content":"Technological advances continue to push the boundaries of what's possible. Takeda's Teresa Bitetti discusses how we are leveraging these tools for cancer patients.\n","featuredImg":{"public_id":"Takeda Oncology/News/our-viewpoints/Teresa_DDT_Static_Article_Image","type":"cloudinary.asset","resource_type":"image","created_by":{"id":"ec6a5b13a6920997f0770195fabdbb","type":"user"},"id":"ec1b8a618de47e04047a01fa10a0f314","secure_url":"https://assets-dam.takeda.com/image/upload/v1705682493/Takeda%20Oncology/News/our-viewpoints/Teresa_DDT_Static_Article_Image.png","url":"http://assets-dam.takeda.com/image/upload/v1705682493/Takeda%20Oncology/News/our-viewpoints/Teresa_DDT_Static_Article_Image.png","folder_id":"c1e80517a809460d7004a5152963235b6c","bytes":883719,"format":"png","access_mode":"public","created_at":"2024-01-19T16:41:33Z","version":1705682493,"metadata":{"epzciwdjuelllku8ngpo":["0001"]},"uploaded_by":{"id":"ec6a5b13a6920997f0770195fabdbb","type":"user"},"height":1080,"width":1920,"__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}},"publishDate":"2024-01-30T20:00:00.000Z","visibleInListings":true,"slug":"/news/our-viewpoints/embracing-AI-emerging-technologies-to-advance-cancer-care","__metadata":{"modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"de9e3207-16b7-412f-8f24-5cc9b89f90b6","createdAt":"2024-01-29T15:53:29Z","updatedAt":"2024-05-30T19:14:55Z"},"type":"Article"},{"featuredImg":{"uploaded_by":{"id":"ec6a5b13a6920997f0770195fabdbb","type":"user"},"created_at":"2023-08-14T15:34:58Z","type":"cloudinary.asset","metadata":{"epzciwdjuelllku8ngpo":["0001"]},"width":1920,"access_mode":"public","secure_url":"https://assets-dam.takeda.com/image/upload/v1692027298/Takeda%20Oncology/News/our-viewpoints/Cancer-Treatment-is-More-Than-Medicine.png","bytes":489014,"created_by":{"id":"ec6a5b13a6920997f0770195fabdbb","type":"user"},"height":1080,"format":"png","resource_type":"image","version":1692027298,"url":"http://assets-dam.takeda.com/image/upload/v1692027298/Takeda%20Oncology/News/our-viewpoints/Cancer-Treatment-is-More-Than-Medicine.png","public_id":"Takeda Oncology/News/our-viewpoints/Cancer-Treatment-is-More-Than-Medicine","__metadata":{"modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}},"description":"Hear from Teresa Bitetti, President of the Global Oncology Business Unit, as she discusses how Takeda and its partners are providing cancer care beyond medicine by supporting other areas of patients' lives, such as finances and mental health.","taxonomies":[{"displayName":"Patients","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"5AQ1D5ZjReEmtg97GZdhmX","createdAt":"2022-10-26T16:28:23Z","updatedAt":"2023-06-08T11:31:34Z"},"type":"Taxonomy"},{"displayName":"our-viewpoints","__metadata":{"modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"E13B866B-3078-4828-ACC7-6843A32C1074","createdAt":"2022-12-12T06:39:00Z","updatedAt":"2023-06-08T11:31:45Z"},"type":"Taxonomy"}],"publishDate":"2023-08-15T15:26:00.000Z","authors":[{"fullName":"Teresa Bitetti","additionalInformation":"President, Global Oncology Business Unit","role":"President","__metadata":{"modelName":"Person","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"E0EC499F0BCF","createdAt":"2022-12-12T06:39:01Z","updatedAt":"2023-06-08T11:31:45Z"},"type":"Person"}],"slug":"/news/our-viewpoints/cancer-treatment-is-more-than-medicine","visibleInListings":true,"title":"Cancer Treatment is More Than Medicine","content":"**Author: Teresa Bitetti, President, Global Oncology Business Unit**\n\nMany of us have loved ones who have been affected by cancer and understand the immense difficulty of processing a diagnosis and beginning treatment, both for the patient and their support network. Through personal and professional conversations with patients, we also recognize that their challenges often extend far beyond the initial diagnosis.\n\nFrom financial and job insecurity, to depression and anxiety, to caregiving responsibilities – cancer treatment can be all-consuming. And while developing innovative medicines to treat cancer is at the heart of what we do as a pharmaceutical company, there is a lesser-known part as critical as the medicine – treating the whole patient. It’s this care beyond medicine where we have devoted more support in recent years.\n\n## Mental Health and Well-Being\n\nA cancer diagnosis can take an incredible toll on mental and emotional health, and recognizing changes in mood and behavior are critical during the journey according to the [American Cancer Society](https://www.cancer.org/cancer/managing-cancer/side-effects/emotional-mood-changes.html). Approximately 35% of patients diagnosed with cancer are impacted by a psychiatric disorder, and another 20% experience clinically relevant distressing psychosocial conditions such as demoralization and health anxiety.\u003csup\u003e1 \u003c/sup\u003eResearch has shown that cancer patients receiving mental health support have better outcomes.\u003csup\u003e2 \u003c/sup\u003eUnfortunately, while mental health support may be a key part of a patient’s treatment journey, it is not always incorporated.\u003csup\u003e3\u003c/sup\u003e\n\nFortunately, there are several ways patients can be supported as they navigate the physical and emotional aspects of cancer. I am impressed by the resources that many of our partner patient advocacy organizations such as [CancerCare](https://www.cancercare.org/) provide – including emotional, practical and financial support – to navigate resources and the underlying emotions associated with diagnosis and treatment.\n\n## Life Necessities and Obligations\n\nA cancer diagnosis does not put life on pause. Patients may still need to feed themselves (and also family members), keep a roof over their heads, continue working, among many other aspects of life. Cancer is stressful enough without the added component of determining how to afford life.\n\nFinancial hardship impacts one in three patients diagnosed with cancer. And the risks disproportionality affect those who are socioeconomically disadvantaged and working-aged patients.\u003csup\u003e4\u003c/sup\u003e The anxiety and stress of affording basic necessities can lead to poorer mental health, which can lead to poorer outcomes, perpetuating a vicious cycle. Fortunately, organizations such as [Family Reach](https://familyreach.org/) provide resources to help patients navigate non-medical expenses. No one should have to make the decision to put treatment on hold to keep food on their table or the lights on at home.\n\nIn addition, patients may also be caregivers – to children, to aging parents, to pets – a role that does not disappear at cancer diagnosis. Caregiving can be emotionally and physically taxing even without managing a cancer diagnosis and treatment. Organizations such as [Cancer Support Community](https://www.cancersupportcommunity.org/) offer resources to support dialogue between patient and those in their care as they navigate this journey together.\n\nCancer treatment is more than medicine. It’s the collaboration and commitment of many stakeholders to ensure that patients receive the care necessary to navigate their journey. At Takeda, I’m proud we partner with patient organizations around the globe – to raise awareness and provide support to help ensure the whole patient is being treated. This is the way we will truly reach our aspiration to cure cancer.\n\n## References:\n\n1. Caruso R, Breitbart W. Mental health care in oncology. Contemporary perspective on the psychosocial burden of cancer and evidence-based interventions. *Epidemiol Psychiatr Sci.* 2020;29:e86. doi:10.1017/S2045796019000866\n\n2. Berchuck JE, Meyer CS, Zhang N, et al. Association of Mental Health Treatment With Outcomes for US Veterans Diagnosed With Non-Small Cell Lung Cancer. *JAMA Oncol.* 2020;6(7):1055-1062. doi:10.1001/jamaoncol.2020.1466\n\n3. Oncology TL. Provision of mental health care for patients with cancer. *The Lancet Oncology*. 2021;22(9):1199. doi:10.1016/S1470-2045(21)00480-0\n\n4. Smith GL, Lopez-Olivo MA, Advani PG, et al. 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