Raw materials for mRNA therapeutics and vaccines

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class="spacer-p-lr x-component-spacing c-title"> <div class="roche-pageType">Product Portfolio</div> <h1 class="roche-title x-h1">Raw materials for mRNA therapeutics and vaccines</h1> </div> </section> <section class="t-prod-listing__banner"> <div><div class="heroMedia section"> <div class="clearfix heroBannerContainer x-component-spacing x-component-spacing-top" data-assettype="image"> <div class="c-heromedia "> <div class="x-hero-banner js-hero-banner "> <div class="layer-cnt ">  <picture> <source media="(max-width: 767px)" srcset="https://roche.scene7.com/is/image/RocheDiaProd/cb-hero-mrna-1440x328?hei=197&fmt=png-alpha&fit=crop,1"/> <source media="(min-width: 1025px)" srcset="https://roche.scene7.com/is/image/RocheDiaProd/cb-hero-mrna-1440x328?hei=328&fmt=png-alpha&fit=crop,1"/> <img data-hotspottarget="10b3f266-e62c-40dd-9aa8-a2e3ec138090" src="https://roche.scene7.com/is/image/RocheDiaProd/cb-hero-mrna-1440x328?hei=328&fmt=png-alpha&fit=crop,1" class=" version-image" 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From vaccines and immunotherapies to protein replacement and cell reprogramming, interest in mRNA manufacturing has surged. Today, therapeutic developers have the room and attention to bring innovations to market. Competition is growing. Regulations are crystalizing.<br /> </p> <p><br /> Remaining at the front of this fast-paced therapeutic space hinges not only on ideas and implementation, but also on development speed and product safety. As a manufacturer, the first are your expertise. As a long-standing global supplier of raw materials, we help make the latter happen. We help you strengthen your supply chain, ease transfers to manufacturing, secure continuous production, and create consistently high-quality products.<br /> <b><br /> This is the “why” of CustomBiotech: GMP Grade and fit-for-purpose raw materials to seize opportunities that improve healthcare.</b><br /> </p> <p><a href="#products" class="noanimation js-rte-analytics" style="background-color: rgb(255,255,255);"><span class="x-arrowlink"><b>View product listing</b></span></a><br /> </p> </div> </div> </div> </div> </div> <div class="faqWithParsys section"> <fieldset> <legend class="x-empty-legend">The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance</legend> <section class="c-faqWithParsys c-faq spacer-p-lr js-expandVar x-component-spacing-top x-component-spacing" data-expand-attr="false" data-module="faqWithParsys"> <h3 class="c-faq__heading x-h3">The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance</h3> <div class="c-faq__row js-faq-row"> <div class="c-faq__row__col js-faq-col" tabindex="0"> <input id="tab-0" type="checkbox" name="tabs2" data-fn-click="true" data-da-satelliteTrackEvent="generic-link-tracking" data-da-link_link-Page-Name="" data-da-link_link-Category="" data-da-link_link-Section="faqWithParsys" data-da-link_link-Header="The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance" data-da-link_link-Text="<p>Template Linearization</p> " data-da-link_link-Interaction-Method=""/> <label for="tab-0" class="c-faq__question" data-fn-click="true" data-da-satelliteTrackEvent="generic-link-tracking" data-da-link_link-Page-Name="" data-da-link_link-Category="" data-da-link_link-Section="faqWithParsys" data-da-link_link-Header="The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance" data-da-link_link-Text="<p>Template Linearization</p> " data-da-link_link-Interaction-Method=""> <div class="c-faq__title"><p>Template Linearization</p> </div> </label> <div class="tab-content "> <div class="c-faq__description"> <div class="clearfix"> <div><div class="columncontrol section"> <div class="x-columncontrol " style="background-color: inherit; padding-top: 0px; padding-bottom: 0px"> <div class="container "> <div> <div class="row"> <div class="col-sm-6 clearfix"> <div class="x-content-wrapper"><div class="generictext section"> <div class="clearfix x-vertical-center-aligned"> <div class=" x-outer-margins x-rte-wrapper title support-alignment x-component-spacing x-component-spacing-top " style="padding-top: 0px"> <div class="x-text "> <p><span class="x-custom-h5"><br /> Restriction endonuclease Xba I</span><br /> from<i> Xanthomonas campestris pv. Badrii</i>, expressed in <i>E. coli</i>, solution</p> </div> </div> </div> </div> </div></div> <div class="col-sm-6 clearfix"> <div class="x-content-wrapper"><div class="ctaButton section"> <div class="x-text-center x-component-spacing"> <a href="/global/en/products/cb/restriction-endonuclease-xba-i-recombinant-aof-pid00000122.html" class="c-cta__link x-submit-button x-sub-hover" target="_self" data-skip-link="true" data-fn-click="true" data-da-satellitetrackevent="generic-link-tracking" data-da-link_link-page-name="" data-da-link_link-category="" data-da-link_link-section="ctaButton" data-da-link_link-text="See product page" data-da-link_link-interaction-method="" role="button"> See product page </a> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="c-faq__row__col js-faq-col" tabindex="0"> <input id="tab-1" type="checkbox" name="tabs2" data-fn-click="true" data-da-satelliteTrackEvent="generic-link-tracking" 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class="x-outer-margins c-feature-table x-component-spacing x-component-spacing-top js-feature-table" data-module="featureTable"> <div class="c-feature-table__btn"> <a href="javascript:void(0)" data-action="featuretable" class="view-btn">View Full Table</a> </div> <div class="row"> <div class="c-feature-table__wrapper js-table featuretable"> <div class="c-feature-table__wrapper__header clearfix"> <div class="left-col"> <a href="javascript:void(0)" class="close js-close" role="button">close </a> </div> </div> <div class="c-feature-table__wrapper__body"> <div class="c-feature-table__wrapper__body__inner js-table-height"> <table cellpadding="-3" cellspacing="0" border="1" width="0" height="0"> <tbody><tr><td><p>Product</p> </td> <td><p>GMP Grade</p> </td> <td>Animal-origin-free<br /> AOF<sup>1</sup></td> <td>Antibiotic-free</td> <td>Tested for RNase/<br /> DNase activity</td> <td><p>Extended impurity testing<sup>2</sup></p> </td> </tr><tr><td valign="middle"><a href="/global/en/products/cb/t7-rna-polymerase-recombinant-gmp-grade-expressed-in-e-coli-36144424.html">T7 RNA Polymerase, rec</a>.</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/pyrophosphatase-recombinant-gmp-grade-315452.html">Pyrophosphatase, rec.</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/rnase-inhibitor-rec-gmp-grade-aof-pid00000124.html">RNase Inhibitor, rec.</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/sp6-rna-polymerase-rec-gmp-grade-pid00000520.html">SP6 RNA Polymerase, rec</a>.</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td colspan="6" height="5"><b>Nucleotides:</b></td> </tr><tr><td><a href="/global/en/products/cb/atp-100-mm-ph-8-3-gmp-gradeaof-pid00000717.html">ATP, 100mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/ctp-100-mm-ph-8-3-gmp-gradeaof-pid00000719.html">CTP, </a><a href="/global/en/products/cb/ctp-100-mm-ph-8-3-gmp-gradeaof-pid00000719.html">100mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/gtp-100-mm-ph-8-3-gmp-gradeaof-pid00000723.html">GTP,</a><a href="/global/en/products/cb/gtp-100-mm-ph-8-3-gmp-gradeaof-pid00000723.html"> </a><a href="/global/en/products/cb/gtp-100-mm-ph-8-3-gmp-gradeaof-pid00000723.html">100mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/utp-100-mm-ph-8-3-gmp-gradeaof-pid00000726.html">UTP,</a><a href="/global/en/products/cb/utp-100-mm-ph-8-3-gmp-gradeaof-pid00000726.html"> </a><a href="/global/en/products/cb/utp-100-mm-ph-8-3-gmp-gradeaof-pid00000726.html">100mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/atp-325-mm-ph-8-3-gmp-gradeaof-pid00000718.html">ATP, 325 mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/ctp-325-mm-ph-8-3-gmp-gradeaof-pid00000720.html">CTP, 325 mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/gtp-325-mm-ph-8-3-gmp-gradeaof-pid00000724.html">GTP, 325 mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/utp-325-mm-ph-8-3-gmp-gradeaof-pid00000727.html">UTP, 325 mM, pH 8.3</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/n1-methyl-pseudo-utp-365548.html">N<sup>1</sup>-Methyl-Pseudo-UTP, AOF</a></td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr><tr><td><a href="/global/en/products/cb/pseudo-utp-aof-pid00000322.html">Pseudo-UTP, AOF</a></td> <td>-</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> <td>Yes</td> </tr></tbody></table> </div> </div> <span class="disclaimer">1 For details see certificates of origin. 2 Includes e.g. testing for bioburden, endotoxin, heavy metals, host-cell DNA, host-cell protein, if applicable </span> </div> </div> </section> </div> </div> </div> </div> </div> </div> <div class="c-faq__row__col js-faq-col" tabindex="0"> <input id="tab-2" type="checkbox" name="tabs2" data-fn-click="true" data-da-satelliteTrackEvent="generic-link-tracking" data-da-link_link-Page-Name="" data-da-link_link-Category="" data-da-link_link-Section="faqWithParsys" data-da-link_link-Header="The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance" data-da-link_link-Text="<p>mRNA Clean-Up</p> " data-da-link_link-Interaction-Method=""/> <label for="tab-2" class="c-faq__question" 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