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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications | Chemical Papers</title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications"/> <meta name="twitter:description" content="Chemical Papers - Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their..."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig1_HTML.png"/> <meta name="journal_id" content="11696"/> <meta name="dc.title" content="Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications"/> <meta name="dc.source" content="Chemical Papers 2023 78:1"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2023-10-07"/> <meta name="dc.type" content="OriginalPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2023 The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences"/> <meta name="dc.rights" content="2023 The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60&nbsp;mV) nanogels of small sizes (dh = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100&nbsp;μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications."/> <meta name="prism.issn" content="2585-7290"/> <meta name="prism.publicationName" content="Chemical Papers"/> <meta name="prism.publicationDate" content="2023-10-07"/> <meta name="prism.volume" content="78"/> <meta name="prism.number" content="1"/> <meta name="prism.section" content="OriginalPaper"/> <meta name="prism.startingPage" content="533"/> <meta name="prism.endingPage" content="546"/> <meta name="prism.copyright" content="2023 The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1007/s11696-023-03108-4"/> <meta name="prism.doi" content="doi:10.1007/s11696-023-03108-4"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1007/s11696-023-03108-4.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1007/s11696-023-03108-4"/> <meta name="citation_journal_title" content="Chemical Papers"/> <meta name="citation_journal_abbrev" content="Chem. Pap."/> <meta name="citation_publisher" content="Springer International Publishing"/> <meta name="citation_issn" content="2585-7290"/> <meta name="citation_title" content="Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications"/> <meta name="citation_volume" content="78"/> <meta name="citation_issue" content="1"/> <meta name="citation_publication_date" content="2024/01"/> <meta name="citation_online_date" content="2023/10/07"/> <meta name="citation_firstpage" content="533"/> <meta name="citation_lastpage" content="546"/> <meta name="citation_article_type" content="Original Paper"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1007/s11696-023-03108-4"/> <meta name="DOI" content="10.1007/s11696-023-03108-4"/> <meta name="size" content="289471"/> <meta name="citation_doi" content="10.1007/s11696-023-03108-4"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1007/s11696-023-03108-4&api_key="/> <meta name="description" content="Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in rec"/> <meta name="dc.creator" content="Abdelmonem, Abuelmagd M."/> <meta name="dc.creator" content="Lavrentieva, Antonina"/> <meta name="dc.creator" content="Bigall, Nadja C."/> <meta name="dc.subject" content="Chemistry/Food Science, general"/> <meta name="dc.subject" content="Industrial Chemistry/Chemical Engineering"/> <meta name="dc.subject" content="Biochemistry, general"/> <meta name="dc.subject" content="Medicinal Chemistry"/> <meta name="dc.subject" content="Materials Science, general"/> <meta name="dc.subject" content="Biotechnology"/> <meta name="citation_reference" content="citation_journal_title=J Inorg Biochem; 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citation_volume=20; citation_issue=4; citation_publication_date=2019; citation_pages=935; citation_doi=10.3390/ijms20040935.PMID:30795518;PMCID:PMC6412445; citation_id=CR87"/> <meta name="citation_author" content="Abdelmonem, Abuelmagd M."/> <meta name="citation_author_email" content="a_almagd@yahoo.com"/> <meta name="citation_author_institution" content="Food Technology Research Institute, Agricultural Research Center, Giza, Egypt"/> <meta name="citation_author_institution" content="Institute of Physical Chemistry and Electrochemistry, Leibniz Universität Hannover, Hannover, Germany"/> <meta name="citation_author" content="Lavrentieva, Antonina"/> <meta name="citation_author_institution" content="Institute of Technical Chemistry, Leibniz Universität Hannover, Hannover, Germany"/> <meta name="citation_author" content="Bigall, Nadja C."/> <meta name="citation_author_institution" content="Food Technology Research Institute, Agricultural Research Center, Giza, Egypt"/> <meta name="citation_author_institution" content="Cluster of Excellence PhoenixD (Photonics, Optics, and Engineering – Innovation Across Disciplines), Hannover, Germany"/> <meta name="format-detection" content="telephone=no"/> <meta name="citation_cover_date" content="2024/01/01"/> <meta property="og:url" content="https://link.springer.com/article/10.1007/s11696-023-03108-4"/> <meta property="og:type" content="article"/> <meta property="og:site_name" content="SpringerLink"/> <meta property="og:title" content="Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications - Chemical Papers"/> <meta property="og:description" content="Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (dh = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications."/> <meta property="og:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig1_HTML.png"/> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/oscar-static/img/favicons/darwin/apple-touch-icon-92e819bf8a.png> <link rel="icon" type="image/png" sizes="192x192" href=/oscar-static/img/favicons/darwin/android-chrome-192x192-6f081ca7e5.png> <link rel="icon" type="image/png" sizes="32x32" href=/oscar-static/img/favicons/darwin/favicon-32x32-1435da3e82.png> <link rel="icon" type="image/png" sizes="16x16" href=/oscar-static/img/favicons/darwin/favicon-16x16-ed57f42bd2.png> <link rel="shortcut icon" data-test="shortcut-icon" 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Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (dh = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications.","datePublished":"2023-10-07T00:00:00Z","dateModified":"2023-10-07T00:00:00Z","pageStart":"533","pageEnd":"546","sameAs":"https://doi.org/10.1007/s11696-023-03108-4","keywords":["Nanogels","Curcumin","Amphiphilic polymer","Surface functionalizable","Biocompatible","Sensing and biomedical","Chemistry/Food Science","general","Industrial Chemistry/Chemical Engineering","Biochemistry","Medicinal Chemistry","Materials Science","Biotechnology"],"image":["https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig1_HTML.png","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig2_HTML.png","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig3_HTML.png","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig4_HTML.png","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig5_HTML.png","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11696-023-03108-4/MediaObjects/11696_2023_3108_Fig6_HTML.png"],"isPartOf":{"name":"Chemical Papers","issn":["2585-7290","0366-6352"],"volumeNumber":"78","@type":["Periodical","PublicationVolume"]},"publisher":{"name":"Springer International Publishing","logo":{"url":"https://www.springernature.com/app-sn/public/images/logo-springernature.png","@type":"ImageObject"},"@type":"Organization"},"author":[{"name":"Abuelmagd M. Abdelmonem","url":"http://orcid.org/0000-0001-8172-2256","affiliation":[{"name":"Food Technology Research Institute, Agricultural Research Center","address":{"name":"Food Technology Research Institute, Agricultural Research Center, Giza, Egypt","@type":"PostalAddress"},"@type":"Organization"},{"name":"Leibniz Universität Hannover","address":{"name":"Institute of Physical Chemistry and Electrochemistry, Leibniz Universität Hannover, Hannover, Germany","@type":"PostalAddress"},"@type":"Organization"}],"email":"a_almagd@yahoo.com","@type":"Person"},{"name":"Antonina Lavrentieva","affiliation":[{"name":"Leibniz Universität Hannover","address":{"name":"Institute of Technical Chemistry, Leibniz Universität Hannover, Hannover, Germany","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"},{"name":"Nadja C. Bigall","affiliation":[{"name":"Food Technology Research Institute, Agricultural Research Center","address":{"name":"Food Technology Research Institute, Agricultural Research Center, Giza, Egypt","@type":"PostalAddress"},"@type":"Organization"},{"name":"Cluster of Excellence PhoenixD (Photonics, Optics, and Engineering – Innovation Across Disciplines)","address":{"name":"Cluster of Excellence PhoenixD (Photonics, Optics, and Engineering – Innovation Across Disciplines), Hannover, Germany","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"}],"isAccessibleForFree":false,"hasPart":{"isAccessibleForFree":false,"cssSelector":".main-content","@type":"WebPageElement"},"@type":"ScholarlyArticle"},"@context":"https://schema.org","@type":"WebPage"}</script> </head> <body class="" >  <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MRVXSHQ" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript>   <noscript data-test="gtm-body"> 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srcset="https://media.springernature.com/w144/springer-static/cover-hires/journal/11696?as=webp 2x" alt=""> </picture> <span class="app-article-masthead__journal-title">Chemical Papers</span> </a> <a href="https://link.springer.com/journal/11696/aims-and-scope" class="app-article-masthead__submission-link" data-track="click_aims_and_scope" data-track-action="aims and scope" data-track-context="article page" data-track-label="link"> Aims and scope <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> <a href="https://www.editorialmanager.com/CHPA/default.aspx" class="app-article-masthead__submission-link" data-track="click_submit_manuscript" data-track-context="article masthead on springerlink article page" data-track-action="submit manuscript" data-track-label="link"> Submit manuscript <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> </div> </div> </div> </section> <div class="c-article-main u-container u-mt-24 u-mb-32 l-with-sidebar" id="main-content" data-component="article-container"> <main class="u-serif js-main-column" data-track-component="article body"> <div class="c-article-header"> <header> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Abuelmagd_M_-Abdelmonem-Aff1-Aff2" data-author-popup="auth-Abuelmagd_M_-Abdelmonem-Aff1-Aff2" data-author-search="Abdelmonem, Abuelmagd M." data-corresp-id="c1">Abuelmagd M. Abdelmonem<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><span class="u-js-hide"> <a class="js-orcid" href="http://orcid.org/0000-0001-8172-2256"><span class="u-visually-hidden">ORCID: </span>orcid.org/0000-0001-8172-2256</a></span><sup class="u-js-hide"><a href="#Aff2">2</a></sup><sup class="u-js-hide"> <a href="#nAff1">nAff1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Antonina-Lavrentieva-Aff3" data-author-popup="auth-Antonina-Lavrentieva-Aff3" data-author-search="Lavrentieva, Antonina">Antonina Lavrentieva</a><sup class="u-js-hide"><a href="#Aff3">3</a></sup> & </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Nadja_C_-Bigall-Aff1-Aff4" data-author-popup="auth-Nadja_C_-Bigall-Aff1-Aff4" data-author-search="Bigall, Nadja C.">Nadja C. Bigall</a><sup class="u-js-hide"><a href="#Aff1">1</a>,<a href="#Aff4">4</a></sup> </li></ul> <div data-test="article-metrics"> <ul class="app-article-metrics-bar u-list-reset"> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-accesses-medium"></use> </svg>198 <span class="app-article-metrics-bar__label">Accesses</span></p> </li> <li class="app-article-metrics-bar__item app-article-metrics-bar__item--metrics"> <p class="app-article-metrics-bar__details"><a href="/article/10.1007/s11696-023-03108-4/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Explore all metrics <svg class="u-icon app-article-metrics-bar__arrow-icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a></p> </li> </ul> </div> <div class="u-mt-32"> </div> </header> </div> <div data-article-body="true" data-track-component="article body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p>Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (<i>d</i><sub><i>h</i></sub> = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications.</p></div></div></section> <div class="c-notes"> <p class="c-notes__text c-status-message--info"> <svg width="24" height="24" focusable="false" role="img" aria-hidden="true" class="c-status-message__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-info-filled-medium"></use> </svg> This is a preview of subscription content, <a id="test-login-banner-link" href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs11696-023-03108-4%3Ferror%3Dcookies_not_supported%26code%3D4b93e1ee-18ea-4b69-902a-d6963d1114fd" data-track="click" data-track-action="login" data-track-label="link" class="c-preview-message__link">log in via an institution</a> <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon c-external-link__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-external-link-small"></use> </svg> to check access. </p> </div> <div data-test="access-article" class="app-article-access"> <h2 class="app-article-access__heading">Access this article</h2> <div class="u-ma-16 u-clear-both"> <a href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs11696-023-03108-4%3Ferror%3Dcookies_not_supported%26code%3D4b93e1ee-18ea-4b69-902a-d6963d1114fd" class="u-button u-button--full-width u-button--primary u-justify-content-space-between c-pdf-download__link" data-track="click" data-track-action="institution access" data-track-label="button"> <span data-test="access-via-institution">Log in via an institution</span> <svg aria-hidden="true" focusable="false" width="24" height="24" class="u-icon"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg> </a> </div> <div data-test="buy-box-mobile" class="c-article-buy-box"> <div class="sprcom-buybox-articleDarwin" id="sprcom-buybox-articleDarwin">  <div class="buying-option" data-test-id="buy-article-darwin"> <div> <div class="c-springer-plus"> <h2 class="springer-plus-heading">Subscribe and save</h2> <div class="springer-plus"> <div class="springer-plus-headline"> <div class="springer-plus-title"> <svg aria-hidden="true" focusable="false" width="16" height="16" class="u-icon"> <use xlink:href="#icon-eds-i-check-filled-medium"></use> </svg><span>Springer+ Basic</span> </div> <div class="dd price-amount-springer-plus"> €32.70 /Month </div> </div> <ul class="buying-option-usps"> <li>Get 10 units per month</li> <li>Download Article/Chapter or eBook</li> <li>1 Unit = 1 Article or 1 Chapter</li> <li>Cancel anytime</li> </ul><a href="https://link.springer.com/product/springer-plus" id="btn-subscribe-springerPlus" class="u-button u-button--full-width u-button--secondary" data-track="click||click_springer_subscribe" data-track-context="buy box"><span>Subscribe now </span> <svg aria-hidden="true" focusable="false" width="16" height="16" class="u-icon"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a> </div> <h2 class="springer-plus-heading">Buy Now</h2> </div> <div class="buybox__buy"> <form action="https://order.springer.com/public/cart" method="post"> <input type="hidden" name="type" value="article"><input type="hidden" name="doi" value="10.1007/s11696-023-03108-4"><input type="hidden" name="isxn" value="2585-7290"><input type="hidden" name="contenttitle" value="Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications"><input type="hidden" name="copyrightyear" value="2023"><input type="hidden" name="year" value="2023"><input type="hidden" name="authors" value="Abuelmagd M. 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The authors would like to acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant agreement 714429), the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) under Germany’s excellence strategy within the cluster of excellence PhoenixD (EXC 2122, project ID 390833453 and the grant BI 1708/4-1) and Hannover School for Nanotechnology (hsn).</p></div></div></section><section aria-labelledby="author-information" data-title="Author information"><div class="c-article-section" id="author-information-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="author-information">Author information</h2><div class="c-article-section__content" id="author-information-content"><span class="c-article-author-information__subtitle u-visually-hidden" id="author-notes">Author notes</span><ol class="c-article-author-information__list"><li class="c-article-author-information__item" id="nAff1"><p class="c-article-author-information__authors-list">Abuelmagd M. Abdelmonem</p><p class="js-present-address">Present address: Food Technology Research Institute, Agricultural Research Center, 9 Cairo University St., Giza, 12619, Egypt</p></li></ol><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Food Technology Research Institute, Agricultural Research Center, 9 Cairo University St., Giza, 12619, Egypt</p><p class="c-article-author-affiliation__authors-list">Nadja C. Bigall</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">Institute of Physical Chemistry and Electrochemistry, Leibniz Universität Hannover, Callinstr. 3a, 30167, Hannover, Germany</p><p class="c-article-author-affiliation__authors-list">Abuelmagd M. Abdelmonem</p></li><li id="Aff3"><p class="c-article-author-affiliation__address">Institute of Technical Chemistry, Leibniz Universität Hannover, Callinstr. 3a, 30167, Hannover, Germany</p><p class="c-article-author-affiliation__authors-list">Antonina Lavrentieva</p></li><li id="Aff4"><p class="c-article-author-affiliation__address">Cluster of Excellence PhoenixD (Photonics, Optics, and Engineering – Innovation Across Disciplines), Hannover, Germany</p><p class="c-article-author-affiliation__authors-list">Nadja C. Bigall</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-Abuelmagd_M_-Abdelmonem-Aff1-Aff2"><span class="c-article-authors-search__title u-h3 js-search-name">Abuelmagd M. 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Bigall</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=Nadja%20C.%20Bigall" class="c-article-button" data-track="click" data-track-action="author link - publication" data-track-label="link" rel="nofollow">View author publications</a></div><div class="c-article-authors-search__item c-article-authors-search__list-item--right"><p class="search-in-title-js c-article-authors-search__text">You can also search for this author in <span class="c-article-identifiers"><a class="c-article-identifiers__item" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nadja%20C.%20Bigall" data-track="click" data-track-action="author link - pubmed" data-track-label="link" rel="nofollow">PubMed</a><span class="u-hide"> </span><a class="c-article-identifiers__item" href="http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nadja%20C.%20Bigall%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en" data-track="click" data-track-action="author link - scholar" data-track-label="link" rel="nofollow">Google Scholar</a></span></p></div></div></li></ol></div><h3 class="c-article__sub-heading" id="corresponding-author">Corresponding author</h3><p id="corresponding-author-list">Correspondence to <a id="corresp-c1" href="mailto:a_almagd@yahoo.com">Abuelmagd M. 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Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications. <i>Chem. Pap.</i> <b>78</b>, 533–546 (2024). https://doi.org/10.1007/s11696-023-03108-4</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1007/s11696-023-03108-4?format=refman&flavour=citation">Download citation<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p><ul class="c-bibliographic-information__list" data-test="publication-history"><li class="c-bibliographic-information__list-item"><p>Received<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2023-01-21">21 January 2023</time></span></p></li><li class="c-bibliographic-information__list-item"><p>Accepted<span 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class="c-article-subject-list__subject"><span><a href="/search?query=Surface%20functionalizable&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">Surface functionalizable</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=Biocompatible&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">Biocompatible</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=Sensing%20and%20biomedical&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">Sensing and biomedical</a></span></li></ul><div data-component="article-info-list"></div></div></div></div></div></section> </div> </main> <div class="c-article-sidebar u-text-sm u-hide-print l-with-sidebar__sidebar" id="sidebar" data-container-type="reading-companion" data-track-component="reading companion"> <aside> <div 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