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October 2021 - Lexaria Bioscience

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(NASDAQ:LEXX)(NASDAQ:LEXXW) (the "Company" or "Lexaria"), a global innovator in drug delivery platforms is pleased to announce that its recent oral tetrahydrocannabinol ("THC") absorption study THC-A21-1 revealed that DehydraTECH<sup>TM</sup>-THC delivered via oral ingestion required only 15 minutes to deliver THC levels in blood plasma comparable to levels achieved at 45 minutes with concentration-matched controls.</p><p>During the study DehydraTECH-THC delivered more THC into bloodstream than the industry standard medium chain triglyceride ("MCT" or "coconut oil") based control formulation from the 2-minute mark onwards, then dropped rapidly to the same level as the MCT control by the 6-hour mark.</p><figure class="image image_resized" style="width:599px"><img src="https://www.accesswire.com/users/newswire/images/667925/Graph-1.png"></figure><p>According to Harvard Medical School, the most common use for medical cannabis in the US is for <a href="https://pr.report/Vp-AF57o">the control of pain</a>. Chronic pain is associated with nerve disorders and multiple sclerosis, and users are frequently cited as responding to a cannabis treatment program, without the highly addictive or sedating effects of opiates. Lexaria's investigation of enhanced delivery characteristics of THC utilizing DehydraTECH technology is focused on medical applications.</p><p>Key pharmacokinetic ("PK") findings from the study are tabulated below demonstrating statistically significant improvements in peak and total THC delivery (i.e., maximum concentration or <a href="https://pr.report/dUm1-eLZ">Cmax</a> and total area under the curve up to the point of the last measurement or <a href="https://pr.report/Wnmh02g1">AUClast</a> respectively):</p><div align="center"><figure class="table" style="width:418.2pt"><table style="border-bottom:none;border-left:none;border-right:none;border-top:none"><tbody><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:120.25pt"><p style="margin-left:0cm;text-align:center"><strong>DehydraTECH-THC Cmax* % Improvement</strong></p><p style="margin-left:0cm;text-align:center">(ng/mL)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:93.4pt"><p style="margin-left:0cm;text-align:center"><strong>MCT Control THC</strong></p><p style="margin-left:0cm;text-align:center">(ng/mL)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:97.95pt"><p style="margin-left:0cm;text-align:center"><strong>DehydraTECH-THCAUClast** % Improvement</strong></p><p style="margin-left:0cm;text-align:center">(hr ng/mL)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:106.6pt"><p style="margin-left:0cm;text-align:center"><strong>MCT (Coconut Oil) Control THC</strong></p><p style="margin-left:0cm;text-align:center">(hr ng/mL)</p></td></tr><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt none windowtext;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:120.25pt"><p style="margin-left:0cm;text-align:center">178.6 &plusmn; 81.1</p><p style="margin-left:0cm;text-align:center"><strong>110.9%</strong></p><p style="margin-left:0cm;text-align:center">(p=0.026)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:93.4pt"><p style="margin-left:0cm;text-align:center">84.7 &plusmn; 43.9</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:97.95pt"><p style="margin-left:0cm;text-align:center">539.2 &plusmn; 190.9</p><p style="margin-left:0cm;text-align:center"><strong>96.5%</strong></p><p style="margin-left:0cm;text-align:center">(p=0.013)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:106.6pt"><p style="margin-left:0cm;text-align:center">274.4 &plusmn; 106.9</p></td></tr></tbody></table></figure></div><p>"The cannabis industry continues to use outdated formulations and processes that ignore the needs of modern THC users," said Chris Bunka, CEO of Lexaria Bioscience Corp. "THC users today include recreational, medicinal and pharmaceutical users, all of whom need technology that doesn't rely on harmful delivery methods such as smoking but still provides rapid onset and high bioavailability which common oral formats do not offer. Our study findings demonstrated rapid delivery, increased overall THC delivery, and higher brain tissue delivery; all of which is consistent with the wants and needs of THC customers."</p><p>DehydraTECH processing continues to prove its ability to deliver drugs more effectively not just into the bloodstream, but also into brain tissue. Only two time-points were selected to collect brain tissue absorption samples, meaning blood concentration levels likely had peaked much earlier, but DehydraTECH-THC brain tissue levels were effectively twice as high as the MCT controls, mirroring what was seen with the blood level readings achieved during the study:</p><div align="center"><figure class="table" style="width:311.35pt"><table style="border-bottom:none;border-left:none;border-right:none;border-top:none"><tbody><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:102.6pt"><p style="margin-left:0cm;text-align:center"><strong>Brain Absorption</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:98.1pt"><p style="margin-left:0cm;text-align:center"><strong>DehydraTECH THC Improvement %</strong></p><p style="margin-left:0cm;text-align:center">(ng/g)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;vertical-align:top;width:110.65pt"><p style="margin-left:0cm;text-align:center"><strong>Coconut-Oil Control THC</strong></p><p style="margin-left:0cm;text-align:center">(ng/g)</p></td></tr><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt none windowtext;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:102.6pt"><p style="margin-left:0cm;text-align:justify"><strong>8-Hours</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:98.1pt"><p style="margin-left:0cm;text-align:center">121.0 &plusmn; 92.6</p><p style="margin-left:0cm;text-align:center"><strong>103.0%</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:110.65pt"><p style="margin-left:0cm;text-align:center">59.6 &plusmn; 20.5</p></td></tr><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt none windowtext;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:102.6pt"><p style="margin-left:0cm;text-align:justify"><strong>24-Hours</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:98.1pt"><p style="margin-left:0cm;text-align:center">14.4 &plusmn; 10.3</p><p style="margin-left:0cm;text-align:center"><strong>108.7%</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;vertical-align:top;width:110.65pt"><p style="margin-left:0cm;text-align:center">6.9 &plusmn; 5.2</p></td></tr></tbody></table></figure></div><p><strong>About Study THC-A21-1</strong></p><p>Study THC-A21-1 was performed by a leading, independent testing laboratory. Blood samples for 20 male Sprague Dawley rats (two groups of 10) are represented in the graph above taken at intervals of 2, 4, 6, 8, 12, 15, 30, 45, and 60 minutes, and at 2, 4 and 6 hours. Brain tissues were collected at 8 and 24 hours.</p><p><strong>About Lexaria Bioscience Corp.</strong></p><p>Lexaria Bioscience Corp.'s patented drug delivery technology, DehydraTECH&#8482;, improves the way active pharmaceutical ingredients (APIs) enter the bloodstream by promoting more effective oral delivery. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids and nicotine by up to 5-10x, reduce time of onset from 1 - 2 hours to minutes, and mask unwanted tastes; and is also being evaluated for orally administered anti-viral drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and more. DehydraTECH has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 21 patents granted and over 50 patents pending worldwide. For more information, please visit <a href="https://pr.report/iorIHyQn">www.lexariabioscience.com</a>.</p><p><strong>CAUTION REGARDING FORWARD-LOOKING STATEMENTS</strong></p><p>This press release includes forward-looking statements. Statements as such term is defined under applicable securities laws. These statements may be identified by words such as "anticipate," "if," "believe," "plan," "estimate," "expect," "intend," "may," "could," "should," "will," and other similar expressions. Such forward-looking statements in this press release include, but are not limited to, statements by the company relating the Company's ability to carry out research initiatives, receive regulatory approvals or grants or experience positive effects or results from any research or study. Such forward-looking statements are estimates reflecting the Company's best judgment based upon current information and involve a number of risks and uncertainties, and there can be no assurance that the Company will actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements. As such, you should not place undue reliance on these forward-looking statements. Factors which could cause actual results to differ materially from those estimated by the Company include, but are not limited to, government regulation and regulatory approvals, managing and maintaining growth, the effect of adverse publicity, litigation, competition, scientific discovery, the patent application and approval process, potential adverse effects arising from the testing or use of products utilizing the DehydraTECH technology, the Company's ability to maintain existing collaborations and realize the benefits thereof, delays or cancellations of planned R&amp;D that could occur related to pandemics or for other reasons, and other factors which may be identified from time to time in the Company's public announcements and periodic filings with the US Securities and Exchange Commission on EDGAR. There is no assurance that any of Lexaria's postulated uses, benefits, or advantages for the patented and patent-pending technology will in fact be realized in any manner or in any part. No statement herein has been evaluated by the Food and Drug Administration (FDA). Lexaria-associated products are not intended to diagnose, treat, cure or prevent any disease. Any forward-looking statements contained in this release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.</p><p><strong>INVESTOR CONTACT:</strong></p><p><a href="/cdn-cgi/l/email-protection#234a51634f465b42514a42414a4c50404a464d40460d404c4e"><span class="__cf_email__" data-cfemail="0b62794b676e736a79626a6962647868626e65686e25686466">[email&#160;protected]</span></a><br>Phone: 250-765-6424, ext 202</p><p><strong>SOURCE:</strong> Lexaria Bioscience Corp.</p><br><br>View source version on accesswire.com: <br><a href='https://www.accesswire.com/667925/Lexarias-Technology-Proven-to-Deliver-Oral-THC-More-Effectively'>https://www.accesswire.com/667925/Lexarias-Technology-Proven-to-Deliver-Oral-THC-More-Effectively</a><br><br><img src='https://www.accesswire.com/img.ashx?id=667925' /></div></div> <div class="themestek-blog-classic-footer-readmore"> <div class="themestek-blogbox-footer-left"><a href="https://lexariabioscience.com/2021/10/13/lexarias-technology-proven-to-deliver-oral-thc-more-effectively/">Read More</a></div> </div> <div class="ts-footer-meta-wrapper"> <span class="ts-footer-meta-line-w ts-footer-meta-line-comments"> <a href="https://lexariabioscience.com/2021/10/13/lexarias-technology-proven-to-deliver-oral-thc-more-effectively/"> <i class="ts-labtechco-icon-comment-1"></i> <span class="comments"> 0 Comments </span> </a> </span> <span class="ts-footer-meta-line-w ts-footer-meta-line-author"> <span class="author vcard"> <span class="screen-reader-text ts-hide">Author </span> <a class="url fn n" href="https://lexariabioscience.com/author/mmcdonald/"><i class="ts-labtechco-icon-user"></i> mmcdonald</a> </span> </span> </div> </div><!-- .entry-content --> </div><!-- .ts-blog-classic-box-content --> </article><!-- #post-## --> <article id="post-8924" class="ts-no-featured-content themestek-box-blog-classic post-8924 post type-post status-publish format-standard hentry category-press-releases" > <div class="ts-blog-classic-featured-wrapper"> <div class="ts-blog-classic-datebox-overlay"> <div class="ts-blog-classic-dbox-date">05</div> <div class="ts-blog-classic-dbox-month">Oct</div> </div> </div> <div class="ts-blog-classic-box-content "> <!-- Blog classic meta Start --> <div class="ts-featured-meta-wrapper ts-featured-overlay"> <div class="ts-blog-post-date"> <span class="ts-meta-line"><span class="screen-reader-text ts-hide">Date </span> <i class="ts-labtechco-icon-clock"></i> <a href="https://lexariabioscience.com/2021/10/05/lexaria-oral-nicotine-study-nic-a21-1-delivers-outstanding-results/">October 5, 2021</a></span> </div> <div class="ts-blog-post-cat ts-blog-post-cat-above-title"> <span class="ts-meta-line cat-links"><span class="screen-reader-text ts-hide">Categories </span> <i class="ts-labtechco-icon-category"></i> <a href="https://lexariabioscience.com/category/press-releases/">Press Releases</a></span> </div> <div class="themestek-box-title"><h4><a href="https://lexariabioscience.com/2021/10/05/lexaria-oral-nicotine-study-nic-a21-1-delivers-outstanding-results/">Lexaria Oral Nicotine Study NIC-A21-1 Delivers Outstanding Results</a></h4></div> </div> <!-- Blog classic meta End --> <div class="entry-content"> <div class="themestek-box-desc-text"><div class="b2iNewsItemBodyDiv"><ul><li><i><strong>DehydraTECH-oral nicotine delivery peaked in bloodstream 10x to 20x faster than controls</strong></i></li><li><i><strong>Peak levels achieved were up to 10x higher than controls</strong></i></li></ul><p><strong>KELOWNA, BC / October 5, 2021 /</strong> Lexaria Bioscience Corp. (NASDAQ:LEXX)(NASDAQ:LEXXW) (the "Company" or "Lexaria"), a global innovator in drug delivery platforms is pleased to announce that its recent oral nicotine absorption study NIC-A21-1 revealed that DehydraTECH<sup>TM</sup>-nicotine delivered via the oral pouch product format required only 2 to 4 minutes to deliver nicotine levels in blood plasma comparable to levels achieved at 45 minutes with concentration-matched controls.</p><p>DehydraTECH-nicotine also reached statistically significant peak blood plasma levels up to 10-fold higher overall than controls (p=0.004) while still clearing from blood virtually as quickly as the controls. Lexaria believes that these findings support the world's fastest-acting nicotine oral mucosal absorption, offering a safer nicotine alternative for the world's 1.1 billion smokers to kick the antiquated habit. The study utilized Lexaria's recently developed, advanced "DehydraTECH 2.0" nicotine formulations and was conducted by a leading, independent testing laboratory in the United States.</p><p>Lexaria's DehydraTECH technology does not function with cigarettes or with vape devices, two outdated nicotine delivery methods that cause unnecessary harm. DehydraTECH is instead focused on assisting the world's smokers and vapers to select less harmful nicotine dosing methods via the oral mucosal absorption route, thereby reducing the carnage caused by smoking.</p><p>In the study, the generic <a href="https://pr.report/1cre6ExQ">nicotine benzoate</a> pouch required approximately 45 minutes to reach its peak delivery rate whereas the DehydraTECH nicotine benzoate pouch reached peak delivery rates at both 8 minutes and again at 30 minutes. In fact, just 4 minutes after the pouch was placed in the mouth, the DehydraTECH-nicotine had reached a higher delivery level than the generic achieved at any point during the study.</p><figure class="image image_resized" style="width:500px"><img src="https://www.accesswire.com/users/newswire/images/666759/Table-1.png"></figure><p style="text-align:center"><strong>DehydraTECH vs. Control NICBZ Formulations Nicotine Plasma Levels (ng/mL)</strong></p><p>Similarly, the generic <a href="https://pr.report/uQYWvpsN">nicotine polacrilex</a> pouch also required approximately 45 minutes to reach its very subdued peak delivery rate while the DehydraTECH nicotine polacrilex pouch achieved a comparable level in just 2 minutes. The DehydraTECH nicotine polacrilex pouch delivered over 10 times the nicotine level in blood plasma at peak than the generic version.</p><figure class="image image_resized" style="width:502px"><img src="https://www.accesswire.com/users/newswire/images/666759/Table-2.png"></figure><p style="text-align:center"><strong>DehydraTECH vs. Control NICPX Formulations Nicotine Plasma Levels (ng/mL)</strong></p><p>Key pharmacokinetic findings from the study are tabulated below demonstrating statistically significant improvements in peak and total nicotine delivery (i.e., maximum concentration or Cmax* and total area under the curve up to the point of the last measurement or AUClast** respectively):</p><div align="center"><figure class="table" style="width:500pt"><table style="border-bottom:none;border-left:none;border-right:none;border-top:none"><tbody><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;text-align:center;width:60.9pt"><p style="margin-left:0cm;text-align:center"><strong>Nicotine Type</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;text-align:center;width:87.7pt"><p style="margin-left:0cm;text-align:center"><strong>DehydraTECH Cmax* % Improvement</strong></p><p style="margin-left:0cm;text-align:center">(ng/mL)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;text-align:center;width:63.15pt"><p style="margin-left:0cm;text-align:center"><strong>Control</strong></p><p style="margin-left:0cm;text-align:center">(ng/mL)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;text-align:center;width:87.7pt"><p style="margin-left:0cm;text-align:center"><strong>DehydraTECH</strong></p><p style="margin-left:0cm;text-align:center"><strong>AUClast** % Improvement</strong></p><p style="margin-left:0cm;text-align:center">(hr ng/mL)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt none windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt solid windowtext;height:59.85pt;padding:0cm 5.4pt;text-align:center;width:69.05pt"><p style="margin-left:0cm;text-align:center"><strong>Control</strong></p><p style="margin-left:0cm;text-align:center">(hr ng/mL)</p></td></tr><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt none windowtext;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:60.9pt"><p style="margin-left:0cm;text-align:center"><strong>Nicotine Benzoate</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:87.7pt"><p style="margin-left:0cm;text-align:center">367.3 &plusmn; 220.2</p><p style="margin-left:0cm;text-align:center"><strong>263%</strong></p><p style="margin-left:0cm;text-align:center">(p=0.002)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:63.15pt"><p style="margin-left:0cm;text-align:center">101.1 &plusmn; 39.0</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:87.7pt"><p style="margin-left:0cm;text-align:center">227.6 &plusmn; 86.2</p><p style="margin-left:0cm;text-align:center"><strong>169%</strong></p><p style="margin-left:0cm;text-align:center">(p=0.0003)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:69.05pt"><p style="margin-left:0cm;text-align:center">84.7 &plusmn; 13.5</p></td></tr><tr><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:1.0pt solid windowtext;border-right:1.0pt solid windowtext;border-top:1.0pt none windowtext;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:60.9pt"><p style="margin-left:0cm;text-align:center"><strong>Nicotine Polacrilex</strong></p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:87.7pt"><p style="margin-left:0cm;text-align:center">344.6 &plusmn; 286.7</p><p style="margin-left:0cm;text-align:center"><strong>1052%</strong></p><p style="margin-left:0cm;text-align:center">(p=0.004)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:63.15pt"><p style="margin-left:0cm;text-align:center">29.9 &plusmn; 15.8</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:87.7pt"><p style="margin-left:0cm;text-align:center">179.3 &plusmn; 73.6</p><p style="margin-left:0cm;text-align:center"><strong>664%</strong></p><p style="margin-left:0cm;text-align:center">(p=0.00004)</p></td><td style="background-color:white;border-bottom:1.0pt solid windowtext;border-left:none;border-right:1.0pt solid windowtext;border-top:none;height:51.15pt;padding:0cm 5.4pt;text-align:center;width:69.05pt"><p style="margin-left:0cm;text-align:center">23.5 &plusmn; 8.7</p></td></tr></tbody></table></figure></div><p>"We are extremely pleased with the performance of our latest DehydraTECH-2.0 nicotine oral pouch formulations in this study," said Chris Bunka, CEO of Lexaria. "Our technology was ten to twenty times faster in delivering comparable levels of nicotine into bloodstream than the peak of the concentration-matched controls and went on to far exceed their total delivery, which should provide much greater consumer satisfaction. Performance gains of this magnitude could be of great significance in enabling the oral pouch product category to offer improved nicotine satiety and effectiveness, with a goal of one day rendering pulmonary administration practices like smoking and vaping as obsolete."</p><p>As a result of the outstanding performance in this nicotine oral mucosal absorption study in animals, Lexaria plans to progress to a larger investigation in human volunteers to compare its DehydraTECH-nicotine pouch performance to that of existing leading brands such as products including Zyn (Swedish Match) and ON! (Altria). Lexaria is currently in the design phase of this proposed human clinical study, which will be independently funded with existing capital. The Company will announce further details as they become available. Lexaria is optimistic that this larger human study will produce positive findings pursuant to those evidenced in its previous 2021 subjective human testing that utilized DehydraTECH-nicotine formulations demonstrating onset of initial nicotine effectiveness in as little as 1.5 to 4 minutes after an oral dose. These results are aligned with the current dog study and compared to an average of 8 to 10 minutes for onset of initial nicotine effectiveness with selected industry products Lexaria previously evaluated.</p><p>The global nicotine oral pouch market is among the fastest growing nicotine sectors in the world, with revenues estimated at $2.3 billion in 2020, <a href="https://pr.report/Oc9LAszt">forecasted to grow to $21.8 billion</a> by 2027. Lexaria believes DehydraTECH is ideally suited for the oral nicotine pouch sector, and that this product format, if empowered with DehydraTECH for rapid and more complete nicotine delivery, could revolutionize the nicotine industry as the first practical, reduced risk category to successfully challenge smoking tobacco. In October 2019, the Food and Drug Administration for the first time ever, authorized reduced risk claims for certain nicotine oral pouches stating that these products "<a href="https://pr.report/m6JNRZpz">put you at lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema, and chronic bronchitis</a>," compared to cigarettes.</p><p>The global tobacco market represents the total revenue generated by all smokers, vapers, and users of all forms of tobacco and nicotine in commercial use today, and <a href="https://pr.report/mr-VDnU4">is an $818 billion market</a>. Historically, alternative nicotine products have failed to deliver consumer satisfaction to a sufficient degree to replace smoking, in part because of the slowness with which the nicotine enters the bloodstream. In a nicotine industry traditionally slow to innovate, Lexaria believes that its fast-acting DehydraTECH oral nicotine could enable development of the best non-combusted oral nicotine product format to deliver that satisfaction.</p><p>Cigarette smoking is one of the world's biggest preventable health hazards, <a href="https://pr.report/Mk4sCzi5">killing 8 million people per year</a>. Lexaria is focused on oral nicotine products that do not contain tobacco in its leaf form. By comparison, Lexaria regards so-called "heat-not-burn" products and vape devices to be inferior intermediate nicotine formats from the perspective of achieving less harmful outcomes.</p><p><strong>About DehydraTECH-Nicotine</strong><br>DehydraTECH-nicotine is a unique nicotine formulation Lexaria has developed and is optimizing, using tobacco-derived nicotine benzoate or nicotine polacrilex raw materials, based on its patented and proprietary DehydraTECH drug delivery technology. Fast-acting DehydraTECH is designed to improve the way active molecules enter the bloodstream upon oral administration. DehydraTECH has also previously demonstrated enhanced delivery of nicotine into brain tissue, which is of particular importance for improved effectiveness and satisfaction.</p><p>The DehydraTECH-nicotine formulations used in the study described herein were based upon Lexaria's latest "DehydraTECH-2.0" advancements and were tested with average potencies of 3.1 mg to 3.3 mg mg of nicotine per pouch for the DehydraTECH nicotine benzoate pouches, and between 3.5 mg to 3.8 mg of nicotine per pouch for the DehydraTECH nicotine polacrilex pouches. The concentration-matched non-DehydraTECH control pouches used in the study were tested with average potencies of 3.1 mg and 3.5 mg of nicotine per pouch respectively.</p><p><strong>About Study NIC-A21-1</strong><br>Study NIC-A21-1 was performed by a leading, independent testing laboratory in 40 anesthetized male beagle dogs weighing roughly 8-14 Kg each. The dogs were divided into four groups of ten, and each had one of the four study test article nicotine pouches placed in their buccal space while laying on their side for a 30-minute duration. The pouches were uniformly squeezed gently every five minutes over this period and care was taken to ensure that saliva did not escape their mouths through the entire two-hour duration of the study observation period. Blood samples were taken at intervals of 0, 2, 4, 6, 8, 10, 15, 30, 45, 60 and 120 minutes. All dogs were well treated, tolerated the pouches well and returned to full health following conclusion of the study.</p><p><strong>About Lexaria Bioscience Corp.</strong><br>Lexaria Bioscience Corp.'s patented drug delivery technology, DehydraTECH&#8482;, improves the way active pharmaceutical ingredients (APIs) enter the bloodstream by promoting more effective oral delivery. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids and nicotine by up to 5-10x, reduce time of onset from 1 - 2 hours to minutes, and mask unwanted tastes; and is also being evaluated for orally administered anti-viral drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and more. DehydraTECH has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 21 patents granted and over 50 patents pending worldwide. For more information, please visit <a href="https://pr.report/QdMuSnHs">www.lexariabioscience.com</a>.</p><p><strong>CAUTION REGARDING FORWARD-LOOKING STATEMENTS</strong><br>This press release includes forward-looking statements. Statements as such term is defined under applicable securities laws. These statements may be identified by words such as "anticipate," "if," "believe," "plan," "estimate," "expect," "intend," "may," "could," "should," "will," and other similar expressions. Such forward-looking statements in this press release include, but are not limited to, statements by the company relating the Company's ability to carry out research initiatives, receive regulatory approvals or grants or experience positive effects or results from any research or study. Such forward-looking statements are estimates reflecting the Company's best judgment based upon current information and involve a number of risks and uncertainties, and there can be no assurance that the Company will actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements. All recreational nicotine products pose risks to users and should be avoided if possible. As such, you should not place undue reliance on these forward-looking statements. Factors which could cause actual results to differ materially from those estimated by the Company include, but are not limited to, government regulation and regulatory approvals, managing and maintaining growth, the effect of adverse publicity, litigation, competition, scientific discovery, the patent application and approval process, potential adverse effects arising from the testing or use of products utilizing the DehydraTECH technology, the Company's ability to maintain existing collaborations and realize the benefits thereof, delays or cancellations of planned R&amp;D that could occur related to pandemics or for other reasons, and other factors which may be identified from time to time in the Company's public announcements and periodic filings with the US Securities and Exchange Commission on EDGAR. There is no assurance that any of Lexaria's postulated uses, benefits, or advantages for the patented and patent-pending technology will in fact be realized in any manner or in any part. No statement herein has been evaluated by the Food and Drug Administration (FDA). Lexaria-associated products are not intended to diagnose, treat, cure or prevent any disease. Any forward-looking statements contained in this release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.</p><p><strong>INVESTOR CONTACT:</strong><br><a href="/cdn-cgi/l/email-protection#09607b49656c71687b60686b60667a6a606c676a6c276a6664"><span class="__cf_email__" data-cfemail="610813210d04190013080003080e120208040f02044f020e0c">[email&#160;protected]</span></a><br>Phone: 250-765-6424, ext 202</p><p><strong>SOURCE:</strong> Lexaria Bioscience Corp.</p><br><br>View source version on accesswire.com: <br><a href='https://www.accesswire.com/666759/Lexaria-Oral-Nicotine-Study-NIC-A21-1-Delivers-Outstanding-Results'>https://www.accesswire.com/666759/Lexaria-Oral-Nicotine-Study-NIC-A21-1-Delivers-Outstanding-Results</a><br><br><img src='https://www.accesswire.com/img.ashx?id=666759' /></div></div> <div class="themestek-blog-classic-footer-readmore"> <div class="themestek-blogbox-footer-left"><a href="https://lexariabioscience.com/2021/10/05/lexaria-oral-nicotine-study-nic-a21-1-delivers-outstanding-results/">Read More</a></div> </div> <div class="ts-footer-meta-wrapper"> <span class="ts-footer-meta-line-w ts-footer-meta-line-comments"> <a href="https://lexariabioscience.com/2021/10/05/lexaria-oral-nicotine-study-nic-a21-1-delivers-outstanding-results/"> <i class="ts-labtechco-icon-comment-1"></i> <span class="comments"> 0 Comments </span> </a> </span> <span class="ts-footer-meta-line-w ts-footer-meta-line-author"> <span class="author vcard"> <span class="screen-reader-text ts-hide">Author </span> <a class="url fn n" href="https://lexariabioscience.com/author/mmcdonald/"><i class="ts-labtechco-icon-user"></i> mmcdonald</a> </span> </span> </div> </div><!-- .entry-content --> </div><!-- .ts-blog-classic-box-content 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(NASDAQ:LEXX) has developed and out-licenses its disruptive and cost-effective DehydraTECH™ technology that promotes healthier administration methods, lower overall dosing and higher effectiveness of ingestible drugs and other beneficial molecules.</p> </aside> </div><!-- .widget-area --> <div class="widget-area col-xs-12 col-sm-4 col-md-4 col-lg-4 first-widget-area"> <aside id="block-35" class="widget-odd widget-5 widget widget_block widget_text"> <p><a href="tel:+12507656424">250.765.6424</a><br><a href="/cdn-cgi/l/email-protection#dfb6b1b9b09fb3baa7beadb6bebdb6b0acbcb6bab1bcbaf1bcb0b2"><span class="__cf_email__" data-cfemail="94fdfaf2fbd4f8f1ecf5e6fdf5f6fdfbe7f7fdf1faf7f1baf7fbf9">[email&#160;protected]</span></a></p> </aside><aside id="block-37" class="widget-even widget-6 widget widget_block widget_text"> <p><b>Canadian Operations</b><br>#100-740 McCurdy Road<br>Kelowna, BC, V1X2P7<br><br><strong>US Operations</strong><br>105 Peach State Court, Suite A<br>Tyrone, GA 30290</p> </aside><aside id="block-31" class="widget-odd widget-7 widget widget_block widget_text"> <p><a href="https://lexariabioscience.com/privacy-policy/">Privacy Policy</a></p> </aside><aside id="block-13" class="widget-even widget-8 widget widget_block"><p><ul id="" class="cnss-social-icon " style="text-align:left;"><li class="cn-fa-facebook cn-fa-icon " style="display:inline-block;"><a class="" target="_blank" href="https://www.facebook.com/lexariabioscience" title="facebook" style="width:28px;height:28px;padding:5px 0;margin:6px;color: #ffffff;border-radius: 0%;"><i title="facebook" style="font-size:18px;" class="fab fa-facebook"></i></a></li><li class="cn-fa-twitter cn-fa-icon " style="display:inline-block;"><a class="" target="_blank" href="https://twitter.com/lexariabiocorp" title="twitter" style="width:28px;height:28px;padding:5px 0;margin:6px;color: #ffffff;border-radius: 0%;"><i title="twitter" style="font-size:18px;" class="fab fa-twitter"></i></a></li><li class="cn-fa-linkedin cn-fa-icon " style="display:inline-block;"><a class="" target="_blank" href="https://www.linkedin.com/company/lexaria-bioscience/" title="linkedin" style="width:28px;height:28px;padding:5px 0;margin:6px;color: #ffffff;border-radius: 0%;"><i title="linkedin" style="font-size:18px;" class="fab fa-linkedin"></i></a></li></ul></p> </aside> </div><!-- .widget-area --> <div class="widget-area col-xs-12 col-sm-4 col-md-4 col-lg-4 first-widget-area"> <aside id="block-10" class="widget-even widget-2 widget widget_block widget_text"> <p><strong>General Disclaimer:</strong><br>No statement in this web site has been evaluated by the Food and Drug Administration (FDA). 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