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class="vector-toc-numb">5</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span 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lang="es" hreflang="es" data-title="CTBP1" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/CTBP1" title="CTBP1 – Persian" lang="fa" hreflang="fa" data-title="CTBP1" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/CTBP1" title="CTBP1 – Russian" lang="ru" hreflang="ru" data-title="CTBP1" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/CTBP1" title="CTBP1 – Tatar" lang="tt" hreflang="tt" data-title="CTBP1" data-language-autonym="Татарча / tatarça" 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class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CTBP1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:6cdf.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fc/6cdf.jpg/250px-6cdf.jpg" decoding="async" width="250" height="199" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fc/6cdf.jpg/375px-6cdf.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fc/6cdf.jpg/500px-6cdf.jpg 2x" data-file-width="1000" data-file-height="797" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=O88712%20or%20Q13363%20or%20D6RAX2">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:O88712,Q13363,D6RAX2">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1MX3">1MX3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4LCE">4LCE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4U6Q">4U6Q</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/2494">CTBP1</a></span>, C-terminal binding protein 1, BARS, HADDTS</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/602618">602618</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1201685">1201685</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1015">1015</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CTBP1">CTBP1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000159692">CTBP1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_4.svg" class="mw-file-description" title="Chromosome 4 (human)"><img alt="Chromosome 4 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_human_chromosome_4.svg/300px-Ideogram_human_chromosome_4.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_human_chromosome_4.svg/450px-Ideogram_human_chromosome_4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_human_chromosome_4.svg/600px-Ideogram_human_chromosome_4.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_4_(human)" class="mw-redirect" title="Chromosome 4 (human)">Chromosome 4 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_4_ideogram.svg" class="mw-file-description" title="Chromosome 4 (human)"><img alt="Chromosome 4 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Human_chromosome_4_ideogram.svg/300px-Human_chromosome_4_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Human_chromosome_4_ideogram.svg/450px-Human_chromosome_4_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Human_chromosome_4_ideogram.svg/600px-Human_chromosome_4_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: -3.4969414506329px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CTBP1"><img alt="Genomic location for CTBP1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 2.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CTBP1"><img alt="Genomic location for CTBP1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">4p16.3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">1,211,445 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">1,249,953 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (mouse)"><img alt="Chromosome 5 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/390px-Ideogram_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/520px-Ideogram_house_mouse_chromosome_5.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 5 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (mouse)"><img alt="Chromosome 5 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/300px-Ideogram_of_house_mouse_chromosome_5.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/450px-Ideogram_of_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/600px-Ideogram_of_house_mouse_chromosome_5.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 59.338501422857px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CTBP1"><img alt="Genomic location for CTBP1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 65.3px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CTBP1"><img alt="Genomic location for CTBP1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">5 B1|5 17.52 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">33,405,067 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">33,432,338 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000159692">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tendon of biceps brachii</li><br /><li style="line-height: 137%;">right hemisphere of cerebellum</li><br /><li style="line-height: 137%;">internal globus pallidus</li><br /><li style="line-height: 137%;">anterior pituitary</li><br /><li style="line-height: 137%;">postcentral gyrus</li><br /><li style="line-height: 137%;">buccal mucosa cell</li><br /><li style="line-height: 137%;">body of pancreas</li><br /><li style="line-height: 137%;">Region I of hippocampus proper</li><br /><li style="line-height: 137%;">stromal cell of endometrium</li><br /><li style="line-height: 137%;">prefrontal cortex</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000037373">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">renal corpuscle</li><br /><li style="line-height: 137%;">medullary collecting duct</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">fetal liver hematopoietic progenitor cell</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">Rostral migratory stream</li><br /><li style="line-height: 137%;">Paneth cell</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li><br /><li style="line-height: 137%;">medial ganglionic eminence</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000159692">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CTBP1_213980_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PBB_GE_CTBP1_213980_s_at_fs.png/250px-PBB_GE_CTBP1_213980_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PBB_GE_CTBP1_213980_s_at_fs.png/375px-PBB_GE_CTBP1_213980_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/34/PBB_GE_CTBP1_213980_s_at_fs.png/500px-PBB_GE_CTBP1_213980_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CTBP1_212863_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6b/PBB_GE_CTBP1_212863_x_at_fs.png/250px-PBB_GE_CTBP1_212863_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6b/PBB_GE_CTBP1_212863_x_at_fs.png/375px-PBB_GE_CTBP1_212863_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6b/PBB_GE_CTBP1_212863_x_at_fs.png/500px-PBB_GE_CTBP1_212863_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CTBP1_203392_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PBB_GE_CTBP1_203392_s_at_fs.png/250px-PBB_GE_CTBP1_203392_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PBB_GE_CTBP1_203392_s_at_fs.png/375px-PBB_GE_CTBP1_203392_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PBB_GE_CTBP1_203392_s_at_fs.png/500px-PBB_GE_CTBP1_203392_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/1487/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016616">oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003714">transcription corepressor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019904">protein domain specific binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051287">NAD binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008134">transcription factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008022">protein C-terminus binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016491">oxidoreductase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016618">hydroxypyruvate reductase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030267">glyoxylate reductase (NADP+) activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005667">transcription regulator complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017053">transcription repressor complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098831">presynaptic active zone cytoplasmic component</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098978">glutamatergic synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098982">GABA-ergic synapse</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031065">positive regulation of histone deacetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019079">viral genome replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051726">regulation of cell cycle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090241">negative regulation of histone H4 acetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006468">protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050872">white fat cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008152">metabolism</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016032">viral process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045892">negative regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035067">negative regulation of histone acetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008285">negative regulation of cell population proliferation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1487&rn=1">1487</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13016&rn=1">13016</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000159692;db=core">ENSG00000159692</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000037373;db=core">ENSMUSG00000037373</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q13363">Q13363</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O88712">O88712</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001012614">NM_001012614</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001328">NM_001328</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377186">NM_001377186</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377187">NM_001377187</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377188">NM_001377188</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377189">NM_001377189</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377190">NM_001377190</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377191">NM_001377191</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377192">NM_001377192</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001377193">NM_001377193</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001198859">NM_001198859</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001198860">NM_001198860</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001198861">NM_001198861</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_013502">NM_013502</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001310535">NM_001310535</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001012632">NP_001012632</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001319">NP_001319</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364115">NP_001364115</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364116">NP_001364116</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364117">NP_001364117</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364118">NP_001364118</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364119">NP_001364119</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364120">NP_001364120</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364121">NP_001364121</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001364122">NP_001364122</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001185788">NP_001185788</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001185789">NP_001185789</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001185790">NP_001185790</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001297464">NP_001297464</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_038530">NP_038530</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr4:1211445-1249953">Chr 4: 1.21 – 1.25 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr5:33405067-33432338">Chr 5: 33.41 – 33.43 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q5014533" class="extiw" title="d:Q5014533">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18248572" class="extiw" title="d:Q18248572">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>C-terminal-binding protein 1</b> also known as <b>CtBP1</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>CTBP1</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid9535825_5-0" class="reference"><a href="#cite_note-pmid9535825-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> CtBP1 is one of two CtBP proteins, the other protein being CtBP2.<sup id="cite_ref-pmid32332713_6-0" class="reference"><a href="#cite_note-pmid32332713-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CTBP1&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the <a href="/wiki/C-terminus" title="C-terminus">C-terminus</a> of adenovirus E1A proteins. It and the related protein <a href="/wiki/CTBP2" title="CTBP2">CTBP2</a> were later shown to function as transcriptional <a href="/wiki/Corepressor" title="Corepressor">corepressors</a>.<sup id="cite_ref-pmid9724649_7-0" class="reference"><a href="#cite_note-pmid9724649-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> That is, regulatory proteins that bind to sequence-specific DNA-binding proteins and help turn genes off. CtBPs do this by recruiting histone modifying enzymes that add repressive histone marks and remove activating marks. CtBP proteins can also self-associate and presumably bring together gene regulatory complexes.<sup id="cite_ref-pmid11864595_8-0" class="reference"><a href="#cite_note-pmid11864595-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>CtBP1 is broadly expressed from embryo to adult, while CtBP2 has a somewhat more restricted pattern of expression. CtBPs have multiple biological roles and appear to be most important in regulating the epithelial to mesenchymal transition, as well as influencing metabolism. They do the latter by binding NADH in preference to NAD+, thereby sensing the <a href="/wiki/Nicotinamide_adenine_dinucleotide#Concentration_and_state_in_cells" title="Nicotinamide adenine dinucleotide">NADH/NAD+ ratio</a>. When bound, it undergoes a conformational change that allows it to dimerize and associate with its partner proteins and silence specific genes. </p><p>During skeletal and T cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1-induced transcriptional silencing. CtBP also binds the <a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Kruppel-like factors</a> family of zinc finger proteins <a href="/wiki/KLF3" title="KLF3">KLF3</a>, <a href="/wiki/KLF8" title="KLF8">KLF8</a> and <a href="/wiki/KLF12" title="KLF12">KLF12</a>. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>C-terminal-binding protein interacting protein (CtIP) is a binding partner with CtBP, which contribute to <a href="/wiki/Transcription_(biology)" title="Transcription (biology)">transcription</a> repression and <a href="/wiki/Cell_cycle" title="Cell cycle">cell cycle</a> regulation, and which have a role in the cellular response to <a href="/wiki/DNA_damage" class="mw-redirect" title="DNA damage">DNA damage</a>.<sup id="cite_ref-pmid17546052_10-0" class="reference"><a href="#cite_note-pmid17546052-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CTBP1&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CTBP1 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/ACTL6B" title="ACTL6B">ACTL6B</a>,<sup id="cite_ref-pmid12565893_11-0" class="reference"><a href="#cite_note-pmid12565893-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ADP_ribosylation_factor" title="ADP ribosylation factor">ARF</a>,<sup id="cite_ref-pmid16508011_12-0" class="reference"><a href="#cite_note-pmid16508011-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/EVI1" class="mw-redirect" title="EVI1">EVI1</a><sup id="cite_ref-pmid11568182_13-0" class="reference"><a href="#cite_note-pmid11568182-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11313276_14-0" class="reference"><a href="#cite_note-pmid11313276-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/FOXP2" title="FOXP2">FOXP2</a>,<sup id="cite_ref-pmid14701752_15-0" class="reference"><a href="#cite_note-pmid14701752-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/HDAC1" title="HDAC1">HDAC1</a>,<sup id="cite_ref-pmid11022042_16-0" class="reference"><a href="#cite_note-pmid11022042-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10995736_17-0" class="reference"><a href="#cite_note-pmid10995736-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9650586_18-0" class="reference"><a href="#cite_note-pmid9650586-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/IKZF1" title="IKZF1">IKZF1</a>,<sup id="cite_ref-pmid10766745_19-0" class="reference"><a href="#cite_note-pmid10766745-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/IKZF4" title="IKZF4">IKZF4</a>,<sup id="cite_ref-pmid12444977_20-0" class="reference"><a href="#cite_note-pmid12444977-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/KLF3" title="KLF3">KLF3</a>,<sup id="cite_ref-pmid9724649_7-1" class="reference"><a href="#cite_note-pmid9724649-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/KLF8" title="KLF8">KLF8</a>,<sup id="cite_ref-pmid10756197_21-0" class="reference"><a href="#cite_note-pmid10756197-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Mdm2" title="Mdm2">Mdm2</a>,<sup id="cite_ref-pmid12867035_22-0" class="reference"><a href="#cite_note-pmid12867035-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a>,<sup id="cite_ref-pmid12829790_23-0" class="reference"><a href="#cite_note-pmid12829790-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/NRIP1" title="NRIP1">NRIP1</a>,<sup id="cite_ref-pmid15060175_24-0" class="reference"><a href="#cite_note-pmid15060175-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18374649_25-0" class="reference"><a href="#cite_note-pmid18374649-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Pinin" title="Pinin">Pinin</a>,<sup id="cite_ref-pmid15542832_26-0" class="reference"><a href="#cite_note-pmid15542832-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RBBP8" title="RBBP8">RBBP8</a>,<sup id="cite_ref-pmid9535825_5-1" class="reference"><a href="#cite_note-pmid9535825-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10196224_27-0" class="reference"><a href="#cite_note-pmid10196224-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/Homeobox_protein_TGIF1" title="Homeobox protein TGIF1">TGIF1</a>.<sup id="cite_ref-pmid10995736_17-1" class="reference"><a href="#cite_note-pmid10995736-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GATA1" title="GATA1">GATA1</a>.<sup id="cite_ref-pmid20587419_28-0" class="reference"><a href="#cite_note-pmid20587419-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28179282_29-0" class="reference"><a href="#cite_note-pmid28179282-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CTBP1&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div 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<span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000037373">GRCm38: Ensembl release 89: ENSMUSG00000037373</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration 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id="CITEREFSnowKimCurrieXu2010" class="citation journal cs1">Snow JW, Kim J, Currie CR, Xu J, Orkin SH (September 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934671">"Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP)"</a>. <i>The Journal of Biological Chemistry</i>. <b>285</b> (36): <span class="nowrap">28064–</span>75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M109.096909">10.1074/jbc.M109.096909</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934671">2934671</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20587419">20587419</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Sumoylation+regulates+interaction+of+FOG1+with+C-terminal-binding+protein+%28CTBP%29&rft.volume=285&rft.issue=36&rft.pages=%3Cspan+class%3D%22nowrap%22%3E28064-%3C%2Fspan%3E75&rft.date=2010-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2934671%23id-name%3DPMC&rft_id=info%3Apmid%2F20587419&rft_id=info%3Adoi%2F10.1074%2Fjbc.M109.096909&rft.aulast=Snow&rft.aufirst=JW&rft.au=Kim%2C+J&rft.au=Currie%2C+CR&rft.au=Xu%2C+J&rft.au=Orkin%2C+SH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2934671&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid28179282-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid28179282_29-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKatsumuraBresnick2017" class="citation journal cs1">Katsumura KR, Bresnick EH (April 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391619">"The GATA factor revolution in hematology"</a>. <i>Blood</i>. <b>129</b> (15): <span class="nowrap">2092–</span>2102. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2016-09-687871">10.1182/blood-2016-09-687871</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391619">5391619</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28179282">28179282</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=The+GATA+factor+revolution+in+hematology&rft.volume=129&rft.issue=15&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2092-%3C%2Fspan%3E2102&rft.date=2017-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5391619%23id-name%3DPMC&rft_id=info%3Apmid%2F28179282&rft_id=info%3Adoi%2F10.1182%2Fblood-2016-09-687871&rft.aulast=Katsumura&rft.aufirst=KR&rft.au=Bresnick%2C+EH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5391619&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CTBP1&action=edit&section=4" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 35em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFChinnadurai_G2002" class="citation journal cs1">Chinnadurai G (2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1097-2765%2802%2900443-4">"CtBP, an unconventional transcriptional corepressor in development and oncogenesis"</a>. <i>Mol. Cell</i>. <b>9</b> (2): <span class="nowrap">213–</span>24. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1097-2765%2802%2900443-4">10.1016/S1097-2765(02)00443-4</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11864595">11864595</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol.+Cell&rft.atitle=CtBP%2C+an+unconventional+transcriptional+corepressor+in+development+and+oncogenesis&rft.volume=9&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E213-%3C%2Fspan%3E24&rft.date=2002&rft_id=info%3Adoi%2F10.1016%2FS1097-2765%2802%2900443-4&rft_id=info%3Apmid%2F11864595&rft.au=Chinnadurai+G&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1097-2765%252802%252900443-4&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSchaeper_UBoyd_JMVerma_SUhlmann1995" class="citation journal cs1">Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G (1995). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40632">"Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. <b>92</b> (23): <span class="nowrap">10467–</span>71. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1995PNAS...9210467S">1995PNAS...9210467S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.92.23.10467">10.1073/pnas.92.23.10467</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40632">40632</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7479821">7479821</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.atitle=Molecular+cloning+and+characterization+of+a+cellular+phosphoprotein+that+interacts+with+a+conserved+C-terminal+domain+of+adenovirus+E1A+involved+in+negative+modulation+of+oncogenic+transformation&rft.volume=92&rft.issue=23&rft.pages=%3Cspan+class%3D%22nowrap%22%3E10467-%3C%2Fspan%3E71&rft.date=1995&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC40632%23id-name%3DPMC&rft_id=info%3Apmid%2F7479821&rft_id=info%3Adoi%2F10.1073%2Fpnas.92.23.10467&rft_id=info%3Abibcode%2F1995PNAS...9210467S&rft.au=Schaeper+U&rft.au=Boyd+JM&rft.au=Verma+S&rft.au=Uhlmann%2C+E&rft.au=Subramanian%2C+T&rft.au=Chinnadurai%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC40632&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBoyd_JMSubramanian_TSchaeper_ULa_Regina1993" class="citation journal cs1">Boyd JM, Subramanian T, Schaeper U, La Regina M, Bayley S, Chinnadurai G (1993). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC413230">"A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis"</a>. <i>EMBO J</i>. <b>12</b> (2): <span class="nowrap">469–</span>78. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1460-2075.1993.tb05679.x">10.1002/j.1460-2075.1993.tb05679.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC413230">413230</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8440238">8440238</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=EMBO+J.&rft.atitle=A+region+in+the+C-terminus+of+adenovirus+2%2F5+E1a+protein+is+required+for+association+with+a+cellular+phosphoprotein+and+important+for+the+negative+modulation+of+T24-ras+mediated+transformation%2C+tumorigenesis+and+metastasis&rft.volume=12&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E469-%3C%2Fspan%3E78&rft.date=1993&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC413230%23id-name%3DPMC&rft_id=info%3Apmid%2F8440238&rft_id=info%3Adoi%2F10.1002%2Fj.1460-2075.1993.tb05679.x&rft.au=Boyd+JM&rft.au=Subramanian+T&rft.au=Schaeper+U&rft.au=La+Regina%2C+M&rft.au=Bayley%2C+S&rft.au=Chinnadurai%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC413230&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSchaeper_USubramanian_TLim_LBoyd1998" class="citation journal cs1">Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.15.8549">"Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif"</a>. <i>J. 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Chem</i>. <b>273</b> (15): <span class="nowrap">8549–</span>52. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.15.8549">10.1074/jbc.273.15.8549</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9535825">9535825</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Interaction+between+a+cellular+protein+that+binds+to+the+C-terminal+region+of+adenovirus+E1A+%28CtBP%29+and+a+novel+cellular+protein+is+disrupted+by+E1A+through+a+conserved+PLDLS+motif&rft.volume=273&rft.issue=15&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8549-%3C%2Fspan%3E52&rft.date=1998&rft_id=info%3Adoi%2F10.1074%2Fjbc.273.15.8549&rft_id=info%3Apmid%2F9535825&rft.au=Schaeper+U&rft.au=Subramanian+T&rft.au=Lim+L&rft.au=Boyd%2C+JM&rft.au=Chinnadurai%2C+G&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.273.15.8549&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSundqvistSollerbrantSvensson1998" class="citation journal cs1">Sundqvist A, Sollerbrant K, Svensson C (1998). 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Biol. Chem</i>. <b>276</b> (28): <span class="nowrap">25834–</span>40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M102343200">10.1074/jbc.M102343200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11328817">11328817</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Evi-1+transforming+and+repressor+activities+are+mediated+by+CtBP+co-repressor+proteins&rft.volume=276&rft.issue=28&rft.pages=%3Cspan+class%3D%22nowrap%22%3E25834-%3C%2Fspan%3E40&rft.date=2001&rft_id=info%3Adoi%2F10.1074%2Fjbc.M102343200&rft_id=info%3Apmid%2F11328817&rft.au=Palmer+S&rft.au=Brouillet+JP&rft.au=Kilbey+A&rft.au=Fulton%2C+R&rft.au=Walker%2C+M&rft.au=Crossley%2C+M&rft.au=Bartholomew%2C+C&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M102343200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSchuierer_MHilger-Eversheim_KDobner_TBosserhoff2001" class="citation journal cs1">Schuierer M, Hilger-Eversheim K, Dobner T, Bosserhoff AK, Moser M, Turner J, Crossley M, Buettner R (2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M100070200">"Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1"</a>. <i>J. Biol. Chem</i>. <b>276</b> (30): <span class="nowrap">27944–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M100070200">10.1074/jbc.M100070200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11373277">11373277</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Induction+of+AP-2alpha+expression+by+adenoviral+infection+involves+inactivation+of+the+AP-2rep+transcriptional+corepressor+CtBP1&rft.volume=276&rft.issue=30&rft.pages=%3Cspan+class%3D%22nowrap%22%3E27944-%3C%2Fspan%3E9&rft.date=2001&rft_id=info%3Adoi%2F10.1074%2Fjbc.M100070200&rft_id=info%3Apmid%2F11373277&rft.au=Schuierer+M&rft.au=Hilger-Eversheim+K&rft.au=Dobner+T&rft.au=Bosserhoff%2C+AK&rft.au=Moser%2C+M&rft.au=Turner%2C+J&rft.au=Crossley%2C+M&rft.au=Buettner%2C+R&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M100070200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACTBP1" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CTBP1&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CTBP1"><i>CTBP1</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CTBP1"><i>CTBP1</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q13363">Q13363</a></i> (C-terminal-binding protein 1) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><style 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style="width:100%;padding:0"><div style="padding:0 0.25em"><ul class="gallery mw-gallery-traditional nochecker" style="line-height:130%"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1hku_EBI.jpg" class="mw-file-description" title="1hku: CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION"><img alt="1hku: CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/PDB_1hku_EBI.jpg/180px-PDB_1hku_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/PDB_1hku_EBI.jpg/270px-PDB_1hku_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/43/PDB_1hku_EBI.jpg/360px-PDB_1hku_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1hku</b>: CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1hl3_EBI.jpg" class="mw-file-description" title="1hl3: CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE"><img alt="1hl3: CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_1hl3_EBI.jpg/180px-PDB_1hl3_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_1hl3_EBI.jpg/270px-PDB_1hl3_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_1hl3_EBI.jpg/360px-PDB_1hl3_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1hl3</b>: CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1mx3_EBI.jpg" class="mw-file-description" title="1mx3: Crystal structure of CtBP dehydrogenase core holo form"><img alt="1mx3: Crystal structure of CtBP dehydrogenase core holo form" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PDB_1mx3_EBI.jpg/180px-PDB_1mx3_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PDB_1mx3_EBI.jpg/270px-PDB_1mx3_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PDB_1mx3_EBI.jpg/360px-PDB_1mx3_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1mx3</b>: Crystal structure of CtBP dehydrogenase core holo form</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2hu2_EBI.png" class="mw-file-description" title="2hu2: CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide"><img alt="2hu2: CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f8/PDB_2hu2_EBI.png/180px-PDB_2hu2_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f8/PDB_2hu2_EBI.png/270px-PDB_2hu2_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f8/PDB_2hu2_EBI.png/360px-PDB_2hu2_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2hu2</b>: CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" 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href="/wiki/Special:EditPage/Template:Transcription_coregulators" title="Special:EditPage/Template:Transcription coregulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transcription_coregulators117" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_coregulator" title="Transcription coregulator">Transcription coregulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Coactivator_(genetics)" title="Coactivator (genetics)">Coactivators</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>ARA</i> (<a href="/wiki/RNF14" title="RNF14">54</a>, <a href="/wiki/TGFB1I1" title="TGFB1I1">55</a>, <a href="/wiki/NCOA4" title="NCOA4">70</a>)</li> <li><a href="/wiki/BCAS3" title="BCAS3">BCAS3</a></li> <li><a href="/wiki/CARM1" title="CARM1">CARM1</a></li> <li><a href="/wiki/P300-CBP_coactivator_family" title="P300-CBP coactivator family">p300-CBP</a> (<a href="/wiki/EP300" title="EP300">EP300</a>, <a href="/wiki/CREB-binding_protein" title="CREB-binding protein">CREBBP</a>)</li> <li><i>CRTC</i> (<a href="/wiki/CRTC1" title="CRTC1">1</a>, <a href="/wiki/CRTC2" title="CRTC2">2</a>, <a href="/wiki/CRTC3" title="CRTC3">3</a>)</li> <li><a href="/wiki/Mediator_(coactivator)" title="Mediator (coactivator)">DRIP/TRAP</a> (<a href="/wiki/MED1" title="MED1">MED1</a> Drip205/Trap220)</li> <li><a href="/wiki/MN1_(gene)" title="MN1 (gene)">MN1</a></li> <li><a href="/wiki/PCAF" title="PCAF">PCAF</a></li> <li><i>PNRC</i> (<a href="/wiki/PNRC1" title="PNRC1">1</a>, <a href="/wiki/PNRC2" title="PNRC2">2</a>)</li> <li><i>PPARGC</i> (<a href="/wiki/PPARGC1A" class="mw-redirect" title="PPARGC1A">1A</a>, <a href="/wiki/PPARGC1B" title="PPARGC1B">1B</a>)</li> <li><a href="/wiki/TGFB1I1" title="TGFB1I1">TGFB1I1</a><br /><a href="/wiki/Nuclear_receptor_coactivator_1" title="Nuclear receptor coactivator 1">NCOA1</a> (<i>SRC-1</i>)</li> <li><a href="/wiki/Nuclear_receptor_coactivator_2" title="Nuclear receptor coactivator 2">NCOA2</a> (<i>GRIP1/SRC-2/TIF2</i>)</li> <li><a href="/wiki/Nuclear_receptor_coactivator_3" title="Nuclear receptor coactivator 3">NCOA3</a> (<i>AIB/SRC-3/TRAM-1</i>)</li> <li><a href="/wiki/NCOA4" title="NCOA4">NCOA4</a> (<i>ARA70</i>)</li> <li><a href="/wiki/NCOA5" title="NCOA5">NCOA5</a> (<i>CIA</i>)</li> <li><a href="/wiki/NCOA6" title="NCOA6">NCOA6</a> (<i>RAP250</i>)</li> <li><a href="/wiki/NCOA7" title="NCOA7">NCOA7</a> (<i>ERAP140</i>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Corepressor" title="Corepressor">Corepressors</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CTBP</i> (<a class="mw-selflink selflink">1</a>, <a href="/wiki/CTBP2" title="CTBP2">2</a>)</li> <li><a href="/wiki/HR_(gene)" title="HR (gene)">Hairless homolog</a></li> <li><a href="/wiki/LCOR" title="LCOR">LCOR</a></li> <li><a href="/wiki/NRIP1" title="NRIP1">NRIP1</a> (<i>RIP140</i>)</li> <li><a href="/wiki/PELP-1" title="PELP-1">PELP-1</a></li> <li><a href="/wiki/RCOR1" title="RCOR1">RCOR1</a></li> <li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/SIN3A" title="SIN3A">SIN3A</a></li> <li><a href="/wiki/SIN3B" title="SIN3B">SIN3B</a></li> <li><a href="/wiki/Tripartite_motif_family" title="Tripartite motif family">Tripartite motif family</a> <i>TRIM</i> (<a href="/wiki/TRIM24" title="TRIM24">24</a>, <a href="/wiki/TRIM28" title="TRIM28">28</a>, <a href="/wiki/TRIM33" title="TRIM33">33</a>)<br /><a href="/wiki/Nuclear_receptor_co-repressor_1" title="Nuclear receptor co-repressor 1">NCOR1</a></li> <li><a href="/wiki/Nuclear_receptor_co-repressor_2" title="Nuclear receptor co-repressor 2">NCOR2</a> (<i>SMRT</i>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">ATP-dependent remodeling factors</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chromatin_Structure_Remodeling_(RSC)_Complex" class="mw-redirect" title="Chromatin Structure Remodeling (RSC) Complex">Chromatin Structure Remodeling (RSC) Complex</a></li> <li><a href="/wiki/SWI/SNF" title="SWI/SNF">SWI/SNF</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://auth.wikimedia.org/loginwiki/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=CTBP1&oldid=1233783319">https://en.wikipedia.org/w/index.php?title=CTBP1&oldid=1233783319</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div 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