CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '92e952722c2bfd06',cH: 'WCEBXr2Po2rG_r4aK1v.HJu4axbbLUjaiQ.qONhvYls-1744362324-1.2.1.1-Qr1M5sgzQy3.bkwo8Le2xoXxjVYOw7M..O_ReYNCIGDcqjoYtXjYu6FzRzbTfyEv',cUPMDTk: "\/doi\/abs\/10.1021\/ed085p1482?__cf_chl_tk=g1gMqsoNjfqtCrLGNw6Nf9D_6gPxu6yyR3WfIojxY9g-1744362324-1.0.1.1-QdiyrHFZO.c2ICOPzFIksPeLhMTRelcoi5DEUOuzp2k",cFPWv: 'b',cITimeS: '1744362324',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "unsupported_browser_beacon",fa: "\/doi\/abs\/10.1021\/ed085p1482?__cf_chl_f_tk=g1gMqsoNjfqtCrLGNw6Nf9D_6gPxu6yyR3WfIojxY9g-1744362324-1.0.1.1-QdiyrHFZO.c2ICOPzFIksPeLhMTRelcoi5DEUOuzp2k",md: "BtHOgf.9RBizZx_DQoz9S0EjXjVfD4BAx_SKiLW9ck8-1744362324-1.2.1.1-Z8M8oLkUbdPMf3XaJ1zmjyviPhQpGlhD.03QyRxEkluEH934vQVANibVKinBB1K2tJXyuX_nYKBA08Zfc3wMgE8Lsf_DjbCX4Yd8FhFrla7VVzIpNZIZaRba3dIJhTeizOfS61hz0t6PKBKP5SamPg_D8zthsUUOmv7kJoeW88_BvvX.qhs_Fv.0elIJJAN2nu1xJgbhokAV3LZmliAgeEezWcijXz.5_DVjE8M26oAu30r75674q1thz6LwOTpyjPMRGQjSGVncTm3W9m792sV8ZzXaku4ywYYhK3roREZqkW.kq77.E1LxzoDI9BYQxa8FFETSPJs8RGMvM9a4GHw45FDFbvTR4xlHQwz9Th5.2oiq96Ant3vAow6ucFFuC0y.zDTqbA9Oat5tjmpBqLiPpqr3Fe819zqMehh8MCi6nSE3.NYeJXRX.e9JN4M2VU7loIV0UZgmLL_YQtHZfbCdc3TyCHDJH_bCx.J5qJX4SWTxm_EQgFRRH78ID6HNpCOaZSJdLa5uo9w4UW7AGgYkiF9rzSbmxt7tR6qq5AyeVepM.JumOY4bjIUJU2htKlurbOcCDiBJbYoVcIIPk.mtIWS7uiLGnoFnqfOgqwKYt8JTT5wGkJc053iVbNjtWIQewC0fpSTbBD0TI9aihtthin49ePwYhe7ScYJgsLUPIzY4mU85I.0wkKkekL8u2sWj3Dt7Zsrr6ItMaZEV19VG2NtkWV68B_WnmuyFhBGhGUjPnu_tdktn0XJ8nU9EaYuf78XjZHSXMQpK8EQUP8ZMteWkJqYwe9bvg4emnCowmoH0RlWr6t.aXsRge20w6M4EnzgLluUB1jT.r.gpyZb8H_GxcxHYZt6_CusyivuBxTMdhXrt5nPsmd3Tth8LlaETFyDZ_AFPKGgbq_8DlUCaGHYf22V.4nx9XWJGvG0WDVfiUv9x3AHiw8eFOU.jBlWqQsi99Rle3X.K3wy3FiLxays7vHydH0utLrvI4OfRprnMD_CuNR4uOHdtK4hvQSiGdJ2.QJ86YO9JN03fi16Z_Ot7em0RgSptw5WK6IN7v8AlMnOeTgLo_h0j7bPofYgNWQ.zNWvwdCY.w70A5LensedbccyD3LTtYPWJnSnxymSYFAwgc2SExeheHriQ0pA7B4xUT4ThVlQbt1hf8XEe1bFTb3ibZ48h01VyHBMcBQR9NLKafn5uPFjKkSRM_kP83GXSpHPMhyKWi.Mi20ZHdgSArkAcPq.M4jl5YL8DWqeb5IvQ4jRVREB.RgKh8l0Fmo.tLrAiSeTR_0HJ.w",mdrd: "AzGhY6J65BTzp12ZTFPwpBihUOUC_XibKQIIWgMczZY-1744362324-1.2.1.1-qwsZ7m8GhGj3TmlKiCmZZyuQbvWMcWFEMqSLuj4fWSdUHiR6F0yaEuVCeSi_2ejc2TI5XgHkxt2jGBDWBdVxt_bGLsrM8EkjD6a4nt7YEF2YCnYIaasvlgKnACL5CUZvBgJgqP8wxaJGxZUtExubBZX8OzAAXs3YY0UmC2nTMq3SBPPzqBeopMYhkUdNjLG1FmpsIHfhgL1Ez3Hf9OcB3KiNWlyia6sc9T1mkkyfB_i2A5yLLF6caX5kVY0P7q6Ou..tnOSfNHVxAXnHkLpcgDq3NQma5iL09gHVSxeHMIfVqcqOtJt08wbivEW9PH.q.9n9kN81EsXrthfXc9Ssiz7Xdcan813GDYh2qldHnqIj2bvGTgLUnyO71UyjJOQQjlwGksTASx2Mz3v.uNaPFYUGGJWwwEjsgkvzqrB1aVem4awJ.3ft6gDjDkTW.UCwU1vvKi1fgva7VYOUDpnscpHBoSd8JAERHy6w_NlcbPBiNaA.9DmM92eMKpwkudgobqvgFmDvb1Rv5rSXGLIYpQUX6hp2zhJd.gAn43SS13XgBZhkf.PkA5g49Fv2WuvDBnvUebkbhdWcivfrrA6Q.BIOUWvSGrHeFqkdi78SGeS_28049orv6__rSpNGgoJLsHePJ80Ce9oykuFCgTAdkXdeN91tAq1mfPh7EKDdnY8TWcjT.7Ofj4ECmplSE2ehHm2BD3YqAyFBNeTG0ycqUSrMq4DYIBllj1rUHKdviSjVpoCq5xOFqlc_ksRTOaZDg_Z4alvg0WNAMJpbCq516q0cFYAVDQPNAwzcD81JYU957Rc4d_o11NOckHDQ1UZSmblVKY50U13XcIOr0fP.jBApcJ3ypL2FilJOI.u3agDa1WRuF3rqKhr0Ja0w55nEQchiqunRfLIEZKBCKilhfgdJwthtpFJ8gqSq_tdWjQheeDRaZkqrAAjZsFWAs9VrzrO4vIjTYl4RsZmkGuNXHCzIvbsIrjyiodyYy45z2huU1VNx1dbieTIt.YuynUmi8l.EloXth8vJIhZZIMifbOSrWsqBqWe5ZYPI9qBopI504bdVdbQlPTAt2yWFUWkIcAfxWyPq19L2FnQIciYQUHfOigNY6bO.0kbSqulkO7bS4fO9vct80VUL4s7PcTNSI7_68IfdW69oDlhEeXp.4Zf8c2RpVl1dcfBjXEsVB6.c7zUnabDLPfPh1xNpxPx7pd7I4ZXFfjsFCXabGYaFYwukPw8zNj7O41UcO14w5EKrGRMO2LNY5.iOJFGT8BPXTsp.pIH1jVIiP7r6WAN8xktR3oDTyQbRna0ByaXlG5mGyGjiZcakSdoN..BxlxSCMlE6oIKJF3BGpU4CqbOOv4lMSbmPY7LzT7esNUyKf97_BOsqmBBXB7q0rsclGpH307V.vtuQdAAk1eEidNVB8u7usTRKB0CrEkQc7vAQ3bBVMDBUKXgmpXXHYNE498ln_6XAAyznQyqDYrdETC3fOAB0ecdkUkWkL0BsFRyD91jTTxpH3l.1BXgfkylixe14qt7CcHAIvfioD6As8jezgtjgIzhQCZBfb3qKv2QcZDJOpHvp984My.VqszNpekCM1Anfjj_mY.6Xr8Kxa6TxK3TosknCHSIHMkhHmEsOM9DKTp7jE8UVhvpz0fRcUaMUjny_Y1952YzLHLy9MpkDfpfhEy0aPeTwpHn_zySbVT6S0QasE1Dm_vhiyFtUKRTFSgt5OPkHzhkHxLV5Yk2Kam699JsrSGpOcY8REwCZb3hqrXUXyi1AwQeg6FwuWHI4eyxWDJgfdUgAMRu4E2waLtZ6qhxzw6Uz95fKJjepWQe4lySpDCjxEH8BcBk.UUGJbuD8wGLeFKy883HsAkQpKN4_9AFqzr.4UTO.o3iVMWNTwC.soeupa3FWP037x2yne8mtxpvdBrfnefF5d4oBvwmZm6Nsd2Ler6D43trQf_E5mBTu59zzxgeOWwvJVEEwCDDQ1ISdNUAxB0siNQTS4v0V1c1c.VcH_FvpIoqkFyHaCdVgQgHTgcZU2JjoXEOJeN63OLBObzKgHgC1fPBN7A"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=92e952722c2bfd06';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1021\/ed085p1482?__cf_chl_rt_tk=g1gMqsoNjfqtCrLGNw6Nf9D_6gPxu6yyR3WfIojxY9g-1744362324-1.0.1.1-QdiyrHFZO.c2ICOPzFIksPeLhMTRelcoi5DEUOuzp2k" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>