Immunology - Merck.com

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class="post-3637301 page type-page status-publish hentry"> <div class="entry-content"> <div id="mco-b2-hero-block-block_0e073a2c6982985ead58ae76a47da5f5" class="mco-b2-hero-block full corporateberg-block mb-2 mt-2"> <div class="mco-b2-hero-block-wrapper"> <div class="mco-b2-hero-block-image-section "> <div class="mco-b2-hero-block-image-container "> <picture> <source media="(max-width: 767px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/10/Immunology-T-Cells-Image-V2.jpg?resize=348,324"> <source media="(min-width: 768px) and (max-width: 1279px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/10/Immunology-T-Cells-Image-V2.jpg?resize=341,524"> <source media="(min-width: 1280px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/10/Immunology-T-Cells-Image-V2.jpg?resize=666,664"> <img data-src="https://www.merck.com/wp-content/uploads/sites/124/2024/10/Immunology-T-Cells-Image-V2.jpg?resize=666,664" alt="Hero Image" class="lazyload" loading="lazy" /> </picture> </div> <div class="mco-b2-hero-block-image-container-two"> <div class='mco-b2-hero-block-green-box'></div> </div> </div> <div class="mco-b2-hero-block-content-section"> <div class="breadcrumbs wrapper text-descriptive"><span><span><a href="https://www.merck.com/research/">Research</a></span> > <span class="breadcrumb_last" aria-current="page">Immunology</span></span></div> <h1>Immunology</h1> <div class="mco-b2-hero-block-description"><p>We’re at the forefront of research, seeking to translate scientific discoveries into treatments for people with immune-mediated inflammatory disorders.</p> <p> </p> </div> <a class="btn" href="https://www.merckclinicaltrials.com/" title="Find a clinical trial" target="_blank">Find a clinical trial</a> </div> </div> </div> <div class="mco-b2-hero-block-modal popup" style="display: none;"> <div class="popup-wrapper"> <div class="mco-b2-hero-block-modal-content popup-content"> </div> </div> </div> <script> let b2_hero_block_modal_triggers = document.getElementsByClassName('mco-b2-hero-block-toggle-btn'); let b2_hero_block_video_type = document.getElementsByClassName('mco-b2-hero-block-video-type'); let b2_hero_block_youtube_url = document.getElementsByClassName('mco-b2-hero-block-youtube-url'); let b2_hero_block_brightcove_info = document.getElementsByClassName('mco-b2-hero-block-brightcove-info'); let b2_hero_block_modals = document.getElementsByClassName('mco-b2-hero-block-modal'); for (let i = 0; i < b2_hero_block_modal_triggers.length; i++) { let trigger = b2_hero_block_modal_triggers[i]; let video_type = b2_hero_block_video_type[i].textContent; let youtube_url = b2_hero_block_youtube_url[i].textContent; let brightcove_info = b2_hero_block_brightcove_info[i].textContent; let modal = b2_hero_block_modals[i]; let modal_content_div = modal.getElementsByClassName('mco-b2-hero-block-modal-content')[0]; trigger.addEventListener('click', function() { if (modal.style.display == "none") { // Load Video Content if (video_type == 'youtube') { // Insert YouTube Iframe into Div let youtube_video_id = youtube_url.split('=')[1].split('&')[0] modal_content_div.innerHTML = `<iframe width='933' height='525' src='https://www.youtube.com/embed/${youtube_video_id}' frameborder='0' allow='accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture' allowfullscreen></iframe>`; } else { // Insert Brightcove Video Info Into Div let account_id = brightcove_info.split(":")[0]; let video_id = brightcove_info.split(":")[1]; modal_content_div.innerHTML = `<video class='video-js vjs-fluid mco-featured-stories-e1-video' data-account='${account_id}' data-player='default' data-embed='default' controls='' data-video-id='${video_id}' data-playlist-id='' data-application-id='' width='960' height='540'></video>`; let brightcove_videos = document.getElementsByClassName("mco-featured-stories-e1-video"); for (let i = 0; i < brightcove_videos.length; i++) { let video = brightcove_videos[i]; let 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"block" : "none"; }); modal.addEventListener('click', function(e) { if (e.target.classList.contains("mco-b2-hero-block-modal") || e.target.classList.contains('popup-wrapper')) { modal.setAttribute('style', 'display: none;'); } }); } </script> <a id="discoveryefforts"></a> <p class="has-text-align-center"><br> <a class="secondary btn" href="#discoveryefforts">Research</a> | <a class="secondary btn" href="#focus">Our focus</a> | <a class="secondary btn" href="#joinmerck">Careers</a> I <a class="secondary btn" href="#collaborations">Collaborations</a></p> <div id="mco-title-block-block_5a8a2b1fc47b5d99fe5a6f16d00ace7b" class="mco-title-block corporateberg-block mb-2 mt-2 aligncenter" > <div class="wrapper"> <div class="mco-title-block-content"> <h2 class="mco-title-block-title">Our immunology research efforts</h2> <p class="mco-title-block-description"><p>We have a proud legacy of developing novel therapeutics for people with immune-mediated inflammatory diseases and autoimmune-related disorders. Our deep knowledge of immuno-oncology and vaccines has laid the foundation for our scientists who are focused on drug discovery and development efforts for immune disorders.</p> </p> </div> </div> </div> <div id="mco-two-column-content-block-block_028a14b583697b57c7032f30ee23d912" class="mco-two-column-content-block corporateberg-block mt-2 mb-2"> <div class="mco-two-column-content-columns-container"> <div class="mco-two-column-content-column"> <div class="mco-two-column-content-col-img-container"> <div class="mco-two-column-content-col-img "> <picture> <source media="(max-width: 767px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/NewModalities.jpg?resize=321,196"> <source media="(min-width: 768px) and (max-width: 1279px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/NewModalities.jpg?resize=314,396"> <source media="(min-width: 1280px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/NewModalities.jpg?resize=628,269"> <img data-src="https://www.merck.com/wp-content/uploads/sites/124/2024/07/NewModalities.jpg?resize=628,269" alt="" class="lazyload" loading="lazy" /> </picture> </div> </div> <div class="mco-two-column-content-col-content-container"> <div class="mco-two-column-content-col-headline">Exploring new modalities</div> <p class="mco-two-column-content-col-description">With an advanced understanding of human biology, there's been an emergence of innovative medicines and new modalities that aim to change the way we approach treatment for immune disorders. We’re investigating targets that have been implicated in many autoimmune-related diseases, including tumor necrosis factor-like ligand 1A (TL1A), interleukin-2 (IL-2) protein and CD30L.</p> <div class="mco-two-column-content-col-cta-container"> </div> </div> </div> <div class="mco-two-column-content-column"> <div class="mco-two-column-content-col-img-container"> <div class="mco-two-column-content-col-img "> <picture> <source media="(max-width: 767px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/PrecisionMe.cine_v2.jpg?resize=321,196"> <source media="(min-width: 768px) and (max-width: 1279px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/PrecisionMe.cine_v2.jpg?resize=314,396"> <source media="(min-width: 1280px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/PrecisionMe.cine_v2.jpg?resize=628,269"> <img data-src="https://www.merck.com/wp-content/uploads/sites/124/2024/07/PrecisionMe.cine_v2.jpg?resize=628,269" alt="" class="lazyload" loading="lazy" /> </picture> </div> </div> <div class="mco-two-column-content-col-content-container"> <div class="mco-two-column-content-col-headline">Bringing precision medicine to immunology</div> <p class="mco-two-column-content-col-description">We’ve made significant investments over the past few years and hope to usher in a new era in immunology. We're pursuing biomarkers that could play a key role in identifying people who are more likely to respond to therapies. The ultimate goal is to be able to deliver the right medicine for the right patient at the right time.</p> <div class="mco-two-column-content-col-cta-container"> </div> </div> </div> </div> <div class="mco-two-column-content-modal-col-one popup" style="display: none;"> <div class="popup-wrapper"> <div id="mco-two-column-content-modal-content" class="mco-two-column-content-modal-content-col-one popup-content"> </div> </div> </div> <div class="mco-two-column-content-modal-col-two popup" style="display: none;"> <div class="popup-wrapper"> <div id="mco-two-column-content-modal-content" class="mco-two-column-content-modal-content popup-content"> </div> </div> </div> </div> <a id="focus"></a> <div id="mco-title-block-block_592447f0acfa6b1fddc15e94e6effa47" class="mco-title-block corporateberg-block mt-2 mb-2 aligncenter" > <div class="wrapper"> <div class="mco-title-block-content"> <h2 class="mco-title-block-title">Our focus on immunology research & treatments</h2> <p class="mco-title-block-description"><p>It’s estimated as many as one in 10 people are living with immune disorders around the world. We’re accelerating our growing capabilities in immunology and evaluating new treatment options for people with certain immune disorders.</p> </p> </div> </div> </div> <div tabindex="0" role=button id="accordion_list_block_e2ee1f65c8367234f29d75624f5e7248" class="b6-accordion-list corporateberg-block mt-1 mb-1"> <h2> <span></span> <button class="btn tertiary" onclick="expandAll_accordion_list_block_e2ee1f65c8367234f29d75624f5e7248()"> <span class="open-text">Expand all</span> <span class="close-text">Close all</span> </button> </h2> <div class="b6-accordion-list-item"> <details role=button tabindex="0" aria-expanded="false" aria-controls="mco-b6-sect0"id="mco-b6-btn0" class="b6-accordion-list-item-details"> <summary class="b6-accordion-list-item-summary"> <h5> Inflammatory bowel disease (IBD)</h5> </summary> <div class="b6-accordion-list-item-content"> <div id="mco-b6-sect0" role = "region" aria-labeledby="mco-b6-btn0" ><p>Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the digestive tract and impacting nearly three million people in the U.S. Crohn’s disease and ulcerative colitis are two of the most common forms of IBD. The unpredictable symptoms associated with IBD, which may include diarrhea, abdominal pain, unintended weight loss and fatigue, often create emotional and social challenges for those impacted.</p> </div> </div> </details> <hr /> </div> <div class="b6-accordion-list-item"> <details role=button tabindex="0" aria-expanded="false" aria-controls="mco-b6-sect1"id="mco-b6-btn1" class="b6-accordion-list-item-details"> <summary class="b6-accordion-list-item-summary"> <h5>Lupus</h5> </summary> <div class="b6-accordion-list-item-content"> <div id="mco-b6-sect1" role = "region" aria-labeledby="mco-b6-btn1" ><p>Systematic lupus erythematosus (SLE) is the most common form of lupus, a chronic multi-organ autoimmune disease primarily affecting women of childbearing age (15 to 44 years). It’s estimated that 1.5 million people in the U.S. have a form of the disease, with SLE accounting for approximately 70 percent of all cases of lupus. The cause of SLE is unknown, but symptoms occur throughout the body, depending on which organs or systems are impacted. People with SLE experience a different combination and severity of symptoms that may come and go and change over time, such as joint pains, skin rash, extreme fatigue or cognitive issues.</p> </div> </div> </details> <hr /> </div> <div class="b6-accordion-list-item"> <details role=button tabindex="0" aria-expanded="false" aria-controls="mco-b6-sect2"id="mco-b6-btn2" class="b6-accordion-list-item-details"> <summary class="b6-accordion-list-item-summary"> <h5>Atopic dermatitis</h5> </summary> <div class="b6-accordion-list-item-content"> <div id="mco-b6-sect2" role = "region" aria-labeledby="mco-b6-btn2" ><p>Atopic dermatitis, more commonly referred to as eczema, is a chronic condition that causes dryness, itchiness and inflammation of the skin. The condition can lead to sleep problems, stigmatization and lower quality of life and may worsen or improve over time, often in cycles of “flares” and “remissions.” Approximately 31.6 million people in the U.S. have atopic dermatitis.</p> </div> </div> </details> <hr /> </div> <div class="b6-accordion-list-item"> <details role=button tabindex="0" aria-expanded="false" aria-controls="mco-b6-sect3"id="mco-b6-btn3" class="b6-accordion-list-item-details"> <summary class="b6-accordion-list-item-summary"> <h5>Vitiligo</h5> </summary> <div class="b6-accordion-list-item-content"> <div id="mco-b6-sect3" role = "region" aria-labeledby="mco-b6-btn3" ><p>Vitiligo is a chronic autoimmune condition that occurs when melanocytes (skin cells that create pigment) are attacked by a person’s own immune system, causing a whitening of the skin or depigmentation in patches. Vitiligo often appears in a symmetrical pattern on both sides of the body, such as on both knees. It is frequently found on the hands, feet, arms and face, but body hair and mucous membranes, such as the inside of the mouth, may also be impacted. Up to 2.8 million people in the U.S. are impacted by vitiligo, which, outside of depigmentation, may lead to low self-esteem and inflammation in the eyes and ears.</p> </div> </div> </details> <hr /> </div> <div class="b6-accordion-list-item"> <details role=button tabindex="0" aria-expanded="false" aria-controls="mco-b6-sect4"id="mco-b6-btn4" class="b6-accordion-list-item-details"> <summary class="b6-accordion-list-item-summary"> <h5>Scleroderma-associated interstitial lung disease (SSc-ILD)</h5> </summary> <div class="b6-accordion-list-item-content"> <div id="mco-b6-sect4" role = "region" aria-labeledby="mco-b6-btn4" ><p>Systemic sclerosis is a rare autoimmune condition that affects connective tissue in the body, typically causing the skin to thicken and tighten. The disease can impact other organs and commonly manifests as interstitial lung disease, which affects the tissue and space around the air sacs of the lungs. Interstitial lung disease caused by systemic sclerosis is known as scleroderma-associated interstitial lung disease (SSc-ILD). Systemic sclerosis impacts approximately 100,000 people in the U.S., with interstitial lung disease occurring in more than half and often associated with a poor prognosis.</p> </div> </div> </details> <hr /> </div> <div class="b6-accordion-list-item"> <details role=button tabindex="0" aria-expanded="false" aria-controls="mco-b6-sect5"id="mco-b6-btn5" class="b6-accordion-list-item-details"> <summary class="b6-accordion-list-item-summary"> <h5>Hidradenitis suppurativa (HS)</h5> </summary> <div class="b6-accordion-list-item-content"> <div id="mco-b6-sect5" role = "region" aria-labeledby="mco-b6-btn5" ><p>Hidradenitis suppurativa, also known as acne inversa, is a condition that causes painful skin lumps, which are often mistaken for pimples and cysts. These lumps are typically found near hair follicles around sweat glands, including the groin, breasts and armpits. Without treatment, the condition can worsen and cause abscesses, or pockets of pus, that can break open and form scars, and may also lead to the formation of tunnels under the skin, called sinus tracts. Hidradenitis suppurativa can have long-term impacts, including decreased mobility due to scarring and chronic intense pain. An estimated 1% of the U.S. population is living with hidradenitis suppurativa and women are three times more likely than men to develop the condition.</p> </div> </div> </details> <hr /> </div> </div> <script> function expandAll_accordion_list_block_e2ee1f65c8367234f29d75624f5e7248() { let accordionList = document.getElementById('accordion_list_block_e2ee1f65c8367234f29d75624f5e7248'); let accordionListItems = accordionList.querySelectorAll('details'); if(!accordionList.classList.contains('all-expanded')) { accordionList.classList.add('all-expanded'); Array.prototype.forEach.call(accordionListItems, function(accordionListItem, i){ accordionListItem.setAttribute('open', 'open'); accordionListItem.setAttribute('aria-expanded', 'true'); }); } else { accordionList.classList.remove('all-expanded'); Array.prototype.forEach.call(accordionListItems, function(accordionListItem, i){ accordionListItem.removeAttribute('open'); accordionListItem.setAttribute('aria-expanded', 'false'); }); } } </script> <p></p> <a id="discoveryefforts"></a> <a id="joinmerck"></a> <div id="mco-b5-content-block-block_88db56fb23bf721cddf2904bb24129a7" class="mco-b5-content-block corporateberg-block mt-2 mb-2 left"> <div class="wrapper parallax-scroll"> <div class="mco-b5-content-block-image-section "> <picture> <source media="(max-width: 767px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/TwoScientistsInLabFinal.jpg?resize=696,425"> <source media="(min-width: 768px) and (max-width: 1279px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/TwoScientistsInLabFinal.jpg?resize=384,468"> <source media="(min-width: 1280px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2024/07/TwoScientistsInLabFinal.jpg?resize=650,544"> <img data-src="https://www.merck.com/wp-content/uploads/sites/124/2024/07/TwoScientistsInLabFinal.jpg?resize=650,544" alt="" class="lazyload mco-image-parallax-zoom-out" loading="lazy" /> </picture> </div> <div class="mco-b5-content-block-content-section parallax-scroll"> <h3>Careers at Merck</h3> <div class="mco-b5-content-block-description"><p>Motivated to advance new research in immunology, we rely on world-class expertise. Our team is always growing, so join us and start making your impact today.</p> </div> <div class="mco-b5-content-block-content-buttons-container"> <a class="btn secondary" href="https://jobs.merck.com/us/en" title="Search jobs" target="">Search jobs</a> </div> </div> </div> </div> <div class="mco-b5-content-block-modal popup" style="display: none;"> <div class="popup-wrapper"> <div class="mco-b5-content-block-modal-content popup-content"> </div> </div> </div> <a id="collaborations"></a> <div id="mco-title-block-block_be3c5a63e0f55aa40c5e352b0c1d84f7" class="mco-title-block corporateberg-block mt-2 mb-2 aligncenter" > <div class="wrapper"> <div class="mco-title-block-content"> <h2 class="mco-title-block-title">Business development & licensing</h2> <p class="mco-title-block-description"><p>We follow the science where we can make the greatest difference, now and in the future. We’ve made significant investments over the past few years in immunology through business development and licensing opportunities.</p> </p> </div> </div> </div> <p class="has-text-align-center"><a class="btn" href="https://www.merck.com/company-overview/business-development-licensing/" target="_blank" rel="noreferrer noopener">Learn more</a></p> <div id="mco-three-column-content-block-block_6a29d416bd30d8259c87d549e2fb5161" class="mco-three-column-content-block corporateberg-block mt-2 mb-1 aligncenter"> <div class="mco-three-column-content-columns-container"> <div class="mco-three-column-content-column"> <div class="mco-three-column-content-col-img-container"> <div class="mco-three-column-content-col-img"> <picture> <source media="(max-width: 767px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2023/12/Prometheus.png?resize=767,469"> <source media="(min-width: 768px) and (max-width: 1279px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2023/12/Prometheus.png?resize=314,280"> <source media="(min-width: 1280px)" data-srcset="https://www.merck.com/wp-content/uploads/sites/124/2023/12/Prometheus.png?resize=404,268"> <img data-src="https://www.merck.com/wp-content/uploads/sites/124/2023/12/Prometheus.png?resize=404,268" class="lazyload" loading="lazy" alt="" /> </picture> </div> </div> <div class="mco-three-column-content-col-content-container"> <p class="mco-three-column-content-col-description">Following our acquisition of Prometheus Biosciences, we hope to usher in a new era of care for immune disorders based on a precision medicine approach.</p> </div> </div> <div class="mco-three-column-content-column"> <div class="mco-three-column-content-col-img-container"> <div class="mco-three-column-content-col-img"> <picture> <source media="(max-width: 767px)" 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