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class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-14122 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="14122"><div class="fl-row fl-row-full-width fl-row-bg-photo fl-node-ratmclz3v451 fl-row-default-height fl-row-align-center" data-node="ratmclz3v451"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-trdfl563yqko" data-node="trdfl563yqko"> <div class="fl-col fl-node-0a7ho8b61rxz fl-col-bg-color" data-node="0a7ho8b61rxz"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-1gkzs46px8oe fl-animation fl-fade-up" data-node="1gkzs46px8oe" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">CONFERENCE DAY TWO</span> </h2> </div> </div> <div class="fl-module fl-module-rich-text fl-node-s3nkp7rjh9mw fl-animation fl-fade-up" data-node="s3nkp7rjh9mw" data-animation-delay="0.2" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><strong>Thursday, December 12, 2024</strong></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-l0rhyn1fdepo fl-row-default-height fl-row-align-center" data-node="l0rhyn1fdepo"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-xm3waiblufyq" data-node="xm3waiblufyq"> <div class="fl-col fl-node-6pk0xg7zrd5c fl-col-bg-color" data-node="6pk0xg7zrd5c"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-t7i6aqxzdfb2" data-node="t7i6aqxzdfb2"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:00 am </span> <span style="color: #BB4E95;">Check-In & Morning Coffee</span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:40 am </span> Chair’s Opening Remarks </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Debunking & Addressing Idiosyncratic Toxicity Amongst Current Covalency Programs to Improve Safety Profiles & Accelerate IND-Filing</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> Profiling Approved Covalent Drugs to Guide Multiparameter Optimization of Covalent Drug Candidates </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23991" class="view-speaker" speaker-id="23991"><span>Micah Niphakis</span></a></em> Director - Chemical Biology, Lundbeck </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Evaluating intrinsic reactivity and <em>in vitro</em> metabolism for representative approved covalent drugs</li> <li>Chemoproteomic profiling to gain insights into covalent binding burden and proteome-wide selectivity</li> <li>Considerations for optimization of covalent drug candidates based on approved covalent drug profiles </li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Chemoproteomic Profiling of Covalent Inhibitors in Multiple Cell Types to Assess Pharmacological Targets & Off-Target Safety Risks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23995" class="view-speaker" speaker-id="23995"><span>Doug Johnson</span></a></em> Senior Director, Biogen </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Chemoproteomic profiling using clickable probes of covalent inhibitors in multiple cell types is a crucial technique for evaluating their proteome-wide selectivity to assess target engagement and off-targets</li> <li>Importance of selecting appropriate cell lines and organ systems for screening covalent inhibitors to comprehensively assess potential off-target toxicities </li> <li>While no single method can definitively determine a compound’s propensity for causing DILI, broadening the scope of chemoproteomic profiling to encompass liver systems in the evaluation of covalent inhibitors could pinpoint off-targets to avoid, thereby helping to mitigate the risk of DILI</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> Accelerating “Speed to Answer” for the Discovery of Covalent Therapeutics </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24443" class="view-speaker" speaker-id="24443"><span>William LaMarr</span></a></em> Senior Vice President of Research & Development, Momentum Biotechnologies </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p></p> <ul> <li><span style="font-family: Aptos, sans-serif;">Integrated workflows that utilize standardized plate maps, automated robotics and high-throughput MS instrumentation to maximize the productivity of the already powerful mass spec based technology</span></li> <li><span style="font-family: Aptos, sans-serif;">High-throughput MS platform enabling covalent library screening at < 15 seconds per sample enabling collections of >10,000 compounds to be screened in ~ 2 days</span></li> <li><span style="font-family: Aptos, sans-serif;">Standardized SOPs using commercially available hardware/software packages producing dozens of potency (Kinact/Ki) and selectivity (peptide mapping) measurements a day</span></li> <li><span style="font-family: Aptos, sans-serif;">Activity based protein profiling (ABPP) workflows elucidating both on-target and off[1]target engagement in a cellular setting</span></li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Fueling the Covalency Renaissance to Increase Investment & Partnership to Expand the Paradigm of Treatable Diseases</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:15 am </span> <span style="color: #BB4E95;">Panel Discussion:</span> : Examining Funding & Investor Perspectives to Fulfil the Future Opportunities of Covalent Drug Discovery & Development </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24003" class="view-speaker" speaker-id="24003"><span>Adam Cotton</span></a></em> Associate, Novartis AG </li> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23977" class="view-speaker" speaker-id="23977"><span>Rhamy Zeid</span></a></em> Vice President, Head of Biology, Nexo Therapeutics </li> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24005" class="view-speaker" speaker-id="24005"><span>Mark Springel</span></a></em> Senior Associate, Vida Ventures LLC </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li><span style="font-family: Helvetica, sans-serif;">What is investible in the current market?</span></li> <li><span style="font-family: Helvetica, sans-serif;">What do investors look for when investing in covalent pipelines? Is a particular target or indication of interest?</span></li> <li><span style="font-family: Helvetica, sans-serif;">How to spark interest from funding and collaboration partners and discussing how assets are considered versus platforms?</span></li> <li><span style="font-family: Helvetica, sans-serif;">What are the challenges of the covalency modality and bringing these to the clinic?</span></li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:00 am </span> <span style="color: #BB4E95;">Morning Break & Scientific Poster Session</span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="color: rgb(187, 78, 149);">As the research, discovery, and development into covalent therapies continues to progress from strength to strength, it is more important than ever to collaborate and learn with your peers, as we continue to advance these therapies to patients in need. Join your colleagues to share your latest data and have the first look into what your peers are working on!</span></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Igniting Covalent Modalities Beyond Inhibition to Harness Diverse Mechanisms of Action for First-in-Class Covalent Drugs</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:00 pm </span> Innovating the Development of Covalent Molecular Glues Displaying Improved Efficacy through Specific & Durable Interactions </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24014" class="view-speaker" speaker-id="24014"><span>Stefan Harry</span></a></em> Postdoctoral Fellow, Harvard Medical School </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Defining the ligandable space of the Cysteinome</li> <li>Utilizing dual-covalent “superglues” to expand the targetable proteome</li> <li>What are the consequences of supergluing proteins?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:30 pm </span> Lessons Learned from Developing Covalent Inhibitors & Covalent PROTACs </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24018" class="view-speaker" speaker-id="24018"><span>Jin Wang</span></a></em> professor, Baylor College of Medicine </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Applying chemoproteomics to characterize covalent inhibitor reactivity in the proteome</li> <li>Developing a covalent BTK PROTAC with single digit nM DC50 </li> <li>Elucidating the ternary complex structure of the covalent BTK PROTAC</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:00 pm </span> A Covalent, Allele-Specific Monovalent Degrader for the Treatment of NASH </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24022" class="view-speaker" speaker-id="24022"><span>Jaimeen Majmudar</span></a></em> Senior Principal Scientist, Pfizer </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Phenotypic screen points to a degrader; MoA determination and target deconvolution</li> <li>Chembio and covalency leveraged to identify a clinical candidate</li> <li>Carrying and de-risking covalency from discovery to clinical development of asset in FIH</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:30 pm </span> <span style="color: #BB4E95;">Lunch Break & Networking </span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Examining Pre-Clinical & Translational Cases to Inform & De-Risk the Strategy for Progressing Emerging Covalent Compounds Towards a Quicker Approval </span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:30 pm </span> Covalent Strategies for Targeting the Kinome </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24030" class="view-speaker" speaker-id="24030"><span>Ken Hsu</span></a></em> Associate Professor - Chemistry, University of Texas at Austin </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Describing the synthesis of sulfonyl-triazoles as a new phenol-reactive group for covalent modification of tyrosine and lysine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry</li> <li>The reactivity of SuTEx chemistry is highly tunable, which can facilitate optimization of potent and selective binders to orthosteric and allosteric sites on kinases</li> <li>Showcasing efforts to use lead SuTEx inhibitors for modulating kinase function in cells</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:00 pm </span> Discovery of the First Approved Covalent FGFR Inhibitor, Futibatinib, by Cysteinomix Drug Discovery Approach </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24034" class="view-speaker" speaker-id="24034"><span>Takeshi Sagara</span></a></em> Managing Director, Clinical Development and Medical Affairs, Discovery & Preclinical Research, Taiho Pharmaceuticals Co.,Ltd. </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>What is the optimal profile of a covalent drug targeting FGFRs, considering target engagement, PKPD, safety and tolerability?</li> <li>How to design covalent binding drugs to capture Cys on highly flexible loop structures</li> <li>What is the desirable platform to continuously deliver covalent binding drug candidates into clinical space?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:30 pm </span> Clinical Development of RSO-021, a Novel Covalent Inhibitor Targeting Mitochondrial PRX3 </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24038" class="view-speaker" speaker-id="24038"><span>George Naumov</span></a></em> COO, RS Oncology Ltd </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>What is the optimal profile of a covalent drug targeting PRX3, considering target engagement, PKPD, safety and tolerability?</li> <li>How to design and implement clinical trials to validate the safety, efficacy, and specificity of covalent modification strategies and with what biomarkers?</li> <li>How to predict and mitigate the long-term effects and potential for cumulative toxicity of covalent drugs in patients?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:00 pm </span> Chairs Closing Remarks </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:05 pm </span> End of 2nd Covalent Drug Discovery & Development Summit </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row 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else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} 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if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var 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$href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba1fe150af69',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else 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menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} 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-'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var 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