Ser456

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href="https://www.ncbi.nlm.nih.gov/blast/Blast.cgi?ALIGNMENTS=50&ALIGNMENT_VIEW=Pairwise&AUTO_FORMAT=Semiauto&CLIENT=web&DATABASE=nr&DESCRIPTIONS=100&ENTREZ_QUERY=(none)&EXPECT=20000&FORMAT_BLOCK_ON_RESPAGE=None&FORMAT_ENTREZ_QUERY=(none)&FORMAT_OBJECT=Alignment&FORMAT_TYPE=HTML&GAPCOSTS=9+1&I_THRESH=0.005&LAYOUT=TwoWindows&MATRIX_NAME=PAM30&NCBI_GI=on&PAGE=Proteins&PROGRAM=blastp&QUERY=DEIFYTLSPVNGKIT&SERVICE=plain&SET_DEFAULTS.x=14&SET_DEFAULTS.y=5&SHOW_LINKOUT=on&SHOW_OVERVIEW=on&WORD_SIZE=2&END_OF_HTTPGET=Yes" class="link12HoverRed" target="_blank">NCBI</a>  <a href="https://www.ncbi.nlm.nih.gov/blast/Blast.cgi?ALIGNMENTS=50&ALIGNMENT_VIEW=Pairwise&AUTO_FORMAT=Semiauto&CLIENT=web&DATABASE=swissprot&DESCRIPTIONS=100&ENTREZ_QUERY=(none)&EXPECT=20000&FORMAT_BLOCK_ON_RESPAGE=None&FORMAT_ENTREZ_QUERY=(none)&FORMAT_OBJECT=Alignment&FORMAT_TYPE=HTML&GAPCOSTS=9+1&I_THRESH=0.005&LAYOUT=TwoWindows&MATRIX_NAME=PAM30&NCBI_GI=on&PAGE=Proteins&PROGRAM=blastp&QUERY=DEIFYTLSPVNGKIT&SERVICE=plain&SET_DEFAULTS.x=14&SET_DEFAULTS.y=5&SHOW_LINKOUT=on&SHOW_OVERVIEW=on&WORD_SIZE=2&END_OF_HTTPGET=Yes" class="link12HoverRed" target="_blank">SwissProt</a>  <a href="https://www.ncbi.nlm.nih.gov/blast/Blast.cgi?ALIGNMENTS=50&ALIGNMENT_VIEW=Pairwise&AUTO_FORMAT=Semiauto&CLIENT=web&DATABASE=pdb&DESCRIPTIONS=100&ENTREZ_QUERY=(none)&EXPECT=20000&FORMAT_BLOCK_ON_RESPAGE=None&FORMAT_ENTREZ_QUERY=(none)&FORMAT_OBJECT=Alignment&FORMAT_TYPE=HTML&GAPCOSTS=9+1&I_THRESH=0.005&LAYOUT=TwoWindows&MATRIX_NAME=PAM30&NCBI_GI=on&PAGE=Proteins&PROGRAM=blastp&QUERY=DEIFYTLSPVNGKITn&SERVICE=plain&SET_DEFAULTS.x=14&SET_DEFAULTS.y=5&SHOW_LINKOUT=on&SHOW_OVERVIEW=on&WORD_SIZE=2&END_OF_HTTPGET=Yes" class="link12HoverRed" target="_blank">PDB</a>  </td> </tr> <tr> <td> <span class="bold02">Site Group ID:</span> <a href="/../siteGroupAction.action?id=3212460&protOrg=4448&showAllSites=true" class="link12HoverRed">3212460</a> </td> </tr> </tbody> </table> <br> <table width="980px" border="0" class="tableOuterBorderColor"> <thead><tr><th colspan="2"><i>In vivo</i> Characterization</th></tr></thead> <tbody> <tr> <td nowrap="nowrap" valign="top" width="35%" class="bold02">Methods used to characterize site <i>in vivo</i>:</td> <td> <div class="viewMoreContent hideViewMorecontent"> <span class="bold02">mass spectrometry</span> ( <a href="#2" class="link12HoverRed">2</a> ,  <a href="#3" class="link12HoverRed">3</a> ,  <a href="#4" class="link12HoverRed">4</a> ,  <a href="#5" class="link12HoverRed">5</a> ,  <a href="#6" class="link12HoverRed">6</a> ,  <a href="#7" class="link12HoverRed">7</a> ,  <a href="#8" class="link12HoverRed">8</a> ,  <a href="#9" class="link12HoverRed">9</a> ,  <a href="#10" class="link12HoverRed">10</a> ,  <a href="#11" class="link12HoverRed">11</a> ,  <a href="#12" class="link12HoverRed">12</a> ,  <a href="#13" class="link12HoverRed">13</a> ,  <a href="#14" class="link12HoverRed">14</a> ,  <a href="#15" class="link12HoverRed">15</a> ,  <a href="#16" class="link12HoverRed">16</a> ,  <a href="#17" class="link12HoverRed">17</a> ,  <a href="#18" class="link12HoverRed">18</a> ) </div> </td> </tr> <tr> <td nowrap="nowrap" valign="top" width="35%" class="bold02">Disease tissue studied:</td> <td> <div class="viewMoreContent hideViewMorecontent"> <span class="bold02">anthrax infection</span> ( <a href="#12" class="link12HoverRed">12</a> ) ,  <span class="bold02">melanoma skin cancer</span> ( <a href="#17" class="link12HoverRed">17</a> ) </div> </td> </tr> <tr> <td nowrap="nowrap" valign="top" width="35%" class="bold02">Relevant cell line - cell type - tissue:</td> <td> <div class="viewMoreContent hideViewMorecontent"> <span class="bold02"> '3T3-L1, differentiated' (adipocyte) </span> ( <a href="#2" class="link12HoverRed">2</a> ,  <a href="#4" class="link12HoverRed">4</a> ) ,  <span class="bold02"> 'fat, brown' </span> ( <a href="#13" class="link12HoverRed">13</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/aa 525-695 ETILLNS...IFEYCC)]~CVCL_0119" class="Link12UnderBlue"> 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 </a> </span> ( <a href="#16" class="link12HoverRed">16</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/CVCL_0119" class="Link12UnderBlue"> 32Dcl3 (myeloid) </a> </span> ( <a href="#16" class="link12HoverRed">16</a> ) ,  <span class="bold02"> brain </span> ( <a href="#8" class="link12HoverRed">8</a> ,  <a href="#9" class="link12HoverRed">9</a> ,  <a href="#13" class="link12HoverRed">13</a> ,  <a href="#15" class="link12HoverRed">15</a> ) ,  <span class="bold02"> heart </span> ( <a href="#5" class="link12HoverRed">5</a> ,  <a href="#13" class="link12HoverRed">13</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/CVCL_0327" class="Link12UnderBlue"> Hepa 1-6 (epithelial) </a> </span> ( <a href="#18" class="link12HoverRed">18</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/CVCL_0303" class="Link12UnderBlue"> HL-1 (myocyte) </a> </span> ( <a href="#3" class="link12HoverRed">3</a> ) ,  <span class="bold02"> kidney </span> ( <a href="#13" class="link12HoverRed">13</a> ) ,  <span class="bold02"> liver </span> ( <a href="#7" class="link12HoverRed">7</a> ) ,  <span class="bold02"> lung </span> ( <a href="#13" class="link12HoverRed">13</a> ) ,  <span class="bold02"> macrophage-bone marrow </span> ( <a href="#14" class="link12HoverRed">14</a> ) ,  <span class="bold02"> macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] </span> ( <a href="#14" class="link12HoverRed">14</a> ) ,  <span class="bold02"> macrophage-peritoneum </span> ( <a href="#6" class="link12HoverRed">6</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/CVCL_4240" class="Link12UnderBlue"> MEF (fibroblast) [p53 (mouse), homozygous knockout] </a> </span> ( <a href="#10" class="link12HoverRed">10</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/CVCL_4240" class="Link12UnderBlue"> MEF (fibroblast) [TSC2 (mouse), homozygous knockout] </a> </span> ( <a href="#11" class="link12HoverRed">11</a> ) ,  <span class="bold02"> <a target="_blank" href="https://web.expasy.org/cellosaurus/CVCL_4240" class="Link12UnderBlue"> MEF (fibroblast) </a> </span> ( <a href="#11" class="link12HoverRed">11</a> ) ,  <span class="bold02"> skin [mGluR1 (mouse), transgenic, TG mutant mice] </span> ( <a href="#17" class="link12HoverRed">17</a> ) ,  <span class="bold02"> spleen </span> ( <a href="#12" class="link12HoverRed">12</a> ,  <a href="#13" class="link12HoverRed">13</a> ) ,  <span class="bold02"> testis </span> ( <a href="#13" class="link12HoverRed">13</a> ) </div> </td> </tr> </tbody> </table> <br> <table width="980px" border="0" class="tableOuterBorderColor"> <thead><tr><th colspan="2">Upstream Regulation</th></tr></thead> <tbody> <tr> <td valign="top" width="35%" class="bold02">Treatments:</td> <td> <div class="viewMoreContent hideViewMorecontent"> <span class="bold02">insulin</span> ( <a href="#4" class="link12HoverRed">4</a> ) ,  <span class="bold02">LPS</span> ( <a href="#14" class="link12HoverRed">14</a> ) ,  <span class="bold02">LY294002</span> ( <a href="#4" class="link12HoverRed">4</a> ) ,  <span class="bold02">MK-2206</span> ( <a href="#4" class="link12HoverRed">4</a> ) </div> </td> </tr> </tbody> </table> <br> <table width="980px" border="0" class="tableCurvedCorners"> <thead><tr><th>References</th><th> </th></tr></thead> <tbody> <tr> <td bgcolor="white" width="5%" valign="top"> <p> <a title="Go to top of page" href="#top" name='1' class="anchor">1</a> </p> </td> <td bgcolor="white"> Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. <i>Nat Commun</i> <b>7</b>, 13250 <br> <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27841257&dopt=Abstract" class="link12HoverRed" target="_blank">27841257</a>   <a href="/../curatedInfoAction.action?record=60078700" styleClass="link12HoverRed">Curated Info</a> </td> </tr> <tr> <td bgcolor="white" width="5%" valign="top"> <p> <a title="Go to top of page" href="#top" name='2' class="anchor">2</a> </p> </td> <td bgcolor="white"> Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. <i>Sci Signal</i> <b>8</b>, rs6 <br> <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26060331&dopt=Abstract" class="link12HoverRed" target="_blank">26060331</a>   <a href="/../curatedInfoAction.action?record=53525010" styleClass="link12HoverRed">Curated Info</a> </td> </tr> <tr> <td bgcolor="white" width="5%" valign="top"> <p> <a title="Go to top of page" href="#top" name='3' class="anchor">3</a> </p> </td> <td bgcolor="white"> Reinartz M, Raupach A, Kaisers W, G枚decke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. <i>J Proteome Res</i> <b>13</b>, 4232-45 <br> <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25162660&dopt=Abstract" class="link12HoverRed" target="_blank">25162660</a>   <a href="/../curatedInfoAction.action?record=59178606" styleClass="link12HoverRed">Curated Info</a> </td> </tr> <tr> <td bgcolor="white" width="5%" valign="top"> <p> <a title="Go to top of page" href="#top" name='4' class="anchor">4</a> </p> </td> <td bgcolor="white"> Humphrey SJ, et al. 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(2013) In vivo phosphoproteomics analysis reveals the cardiac targets of 尾-adrenergic receptor signaling. <i>Sci Signal</i> <b>6</b>, rs11 <br> <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23737553&dopt=Abstract" class="link12HoverRed" target="_blank">23737553</a>   <a href="/../curatedInfoAction.action?record=34484100" styleClass="link12HoverRed">Curated Info</a> </td> </tr> <tr> <td bgcolor="white" width="5%" valign="top"> <p> <a title="Go to top of page" href="#top" name='6' class="anchor">6</a> </p> </td> <td bgcolor="white"> Wu X, et al. 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