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<!DOCTYPE html> <html lang="en-US"> <head> <meta charset="UTF-8" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <link rel="pingback" href="https://www.progeriaresearch.org/xmlrpc.php" /> <script type="text/javascript"> document.documentElement.className = 'js'; </script> <link rel="preconnect" href="https://fonts.gstatic.com" crossorigin /><style id="et-builder-googlefonts-cached-inline">/* Original: https://fonts.googleapis.com/css?family=Nunito+Sans:200,200italic,300,300italic,regular,italic,600,600italic,700,700italic,800,800italic,900,900italic|Lato:100,100italic,300,300italic,regular,italic,700,700italic,900,900italic&subset=latin,latin-ext&display=swap *//* User Agent: Mozilla/5.0 (Unknown; Linux x86_64) AppleWebKit/538.1 (KHTML, like Gecko) Safari/538.1 Daum/4.1 */@font-face {font-family: 'Lato';font-style: italic;font-weight: 100;font-display: swap;src: url(https://fonts.gstatic.com/s/lato/v24/S6u-w4BMUTPHjxsIPx-mPCc.ttf) format('truetype');}@font-face {font-family: 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</header>  <div id="et-main-area"> <div id="main-content"> <article id="post-1012" class="post-1012 page type-page status-publish hentry"> <div class="entry-content"> <div class="et-l et-l--post"> <div class="et_builder_inner_content et_pb_gutters3"> <div class="et_pb_with_border et_pb_section et_pb_section_0 et_pb_fullwidth_section et_section_regular" > <section class="et_pb_module et_pb_fullwidth_header et_pb_fullwidth_header_0 et_pb_text_align_left et_pb_bg_layout_dark"> <div class="et_pb_fullwidth_header_container left"> <div class="header-content-container center"> <div class="header-content"> <div class="et_pb_header_content_wrapper"><h1 class="vc_custom_heading" data-fontsize="34" data-lineheight="48">PRF Cell and Tissue</h1> <h1 class="vc_custom_heading" data-fontsize="34" data-lineheight="48">Bank Publications</h1> <p> </p></div> </div> </div> </div> <div class="et_pb_fullwidth_header_overlay"></div> <div class="et_pb_fullwidth_header_scroll"></div> </section> </div><div class="et_pb_with_border et_pb_section et_pb_section_1 handprint-bg et_pb_section_parallax et_pb_with_background et_section_specialty" > <span class="et_parallax_bg_wrap"><span class="et_parallax_bg et_pb_parallax_css" style="background-image: url(https://www.progeriaresearch.org/wp-content/uploads/2019/04/blue-handprint-only.png);" ></span></span> <div class="et_pb_row et_pb_gutters1"> <div class="et_pb_column et_pb_column_1_4 et_pb_column_0 sidebar-secondary-nav et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_with_border et_pb_module et_pb_sidebar_0 subpage-sidebars et_animated et_pb_widget_area clearfix et_pb_widget_area_left et_pb_bg_layout_light"> <div id="nav_menu-12" class="et_pb_widget widget_nav_menu"><div class="menu-cell-bank-menu-container"><ul id="menu-cell-bank-menu" class="menu"><li id="menu-item-6526" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6526"><a href="https://www.progeriaresearch.org/cell-and-tissue-bank/">Cell and Tissue Bank</a></li> <li id="menu-item-6527" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6527"><a href="https://www.progeriaresearch.org/available-cell-lines/">Available Cell Lines</a></li> <li id="menu-item-6528" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6528"><a href="https://www.progeriaresearch.org/ordering-information/">Ordering Information</a></li> <li id="menu-item-6529" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6529"><a href="https://www.progeriaresearch.org/lymphoblast-cell-culture-protocols/">Lymphoblast Cell Culture Protocols</a></li> <li id="menu-item-6530" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6530"><a href="https://www.progeriaresearch.org/fibroblast-cell-culture-protocols/">Fibroblast Cell Culture Protocols</a></li> <li id="menu-item-6531" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6531"><a href="https://www.progeriaresearch.org/immortalized-cell-culture-protocols/">Immortalized Cell Culture Protocols</a></li> <li id="menu-item-6532" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-6532"><a href="https://www.progeriaresearch.org/induced-pluripotent-stem-cells/">Induced Pluripotent Stem Cells</a></li> <li id="menu-item-9416" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-9416"><a href="https://www.progeriaresearch.org/lonafarnib-pre-clinical-drug-supply-program/">Lonafarnib Pre-clinical Drug Supply Program</a></li> <li id="menu-item-6533" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page current-menu-item page_item page-item-1012 current_page_item menu-item-6533"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/" aria-current="page">PRF Cell and Tissue Bank Publications</a></li> <li id="menu-item-15907" class="subpage-sidebar-menu menu-item menu-item-type-post_type menu-item-object-page menu-item-15907"><a href="https://www.progeriaresearch.org/cell-and-tissue-bank-recipients/">Cell and Tissue Bank Recipients</a></li> </ul></div></div> </div> </div><div class="et_pb_column et_pb_column_3_4 et_pb_column_1 et_pb_specialty_column et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_row_inner et_pb_row_inner_0"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_inner et_pb_column_inner_0 et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>Publications Stemming From<br /></strong></h4> <h5>The Progeria Research Foundation Cell and Tissue Bank</h5> <p><a name="top"></a>The Progeria Research Foundation Cell and Tissue Bank has contributed to the following medical publications, categorized by cell line and other biological sample types for researcher convenience.</p> <p></p></div> </div><div class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4> <table id="tablepress-2" class="tablepress tablepress-id-2 publications-table"> <tbody> <tr class="row-1"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN001">HGADFN001</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN003">HGADFN003</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN005">HGADFN005</a></td> </tr> <tr class="row-2"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN008">HGADFN008</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN014">HGADFN014</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN090">HGMDFN090</a></td> </tr> <tr class="row-3"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN122">HGADFN122</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN127">HGADFN127</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN136">HGADFN136</a></td> </tr> <tr class="row-4"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN143">HGADFN143</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN155">HGADFN155</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN164">HGADFN164</a></td> </tr> <tr class="row-5"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN167">HGADFN167</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFDFN168">HGFDFN168</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN169"> HGADFN169</a></td> </tr> <tr class="row-6"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN178">HGADFN178</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN188">HGADFN188</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN271">HGADFN271</a></td> </tr> <tr class="row-7"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN367">HGADFN367</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN368">HGMDFN368</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFDFN369">HGFDFN369</a></td> </tr> <tr class="row-8"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN370">HGADFN370</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN371">HGMDFN371</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN496">HGADFN496</a></td> </tr> <tr class="row-9"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN717">HGMDFN717</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN718">HGMDFN718</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN086">PSADFN086</a></td> </tr> <tr class="row-10"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN004">PSADFN004</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN257">PSADFN257</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN317">PSADFN317</a></td> </tr> <tr class="row-11"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN318">PSADFN318</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSFDFN319">PSFDFN319</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSMDFN320">PSMDFN320</a></td> </tr> <tr class="row-12"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSMDFN326">PSMDFN326</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSFDFN327">PSFDFN327</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSMDFN346"> PSMDFN346</a></td> </tr> <tr class="row-13"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN363">PSADFN363</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN373">PSADFN373</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN423">PSADFN423 </a></td> </tr> <tr class="row-14"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN485">PSADFN485 </a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN542">PSADFN542 </a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN386">PSADFN386</a></td> </tr> <tr class="row-15"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSMDFN371">PSMDFN371</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSMDFN387">PSMDFN387</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSFDFN388">PSFDFN388</a></td> </tr> <tr class="row-16"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN392">PSADFN392</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSMDFN393">PSMDFN393</a></td><td class="column-3"></td> </tr> <tr class="row-17"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSFDFN394">PSFDFN394</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN414">PSADFN414</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#PSADFN425">PSADFN425</a></td> </tr> <tr class="row-18"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGALBV009">HGALBV009</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMLBV010">HGMLBV010</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGALBV011">HGALBV011</a></td> </tr> <tr class="row-19"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMLBV013">HGMLBV013</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFLBV021">HGFLBV021</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMLBV023">HGMLBV023</a></td> </tr> <tr class="row-20"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFLBV031">HGFLBV031</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFLBV050">HGFLBV050</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGALBV057">HGALBV057</a></td> </tr> <tr class="row-21"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMLBV058">HGMLBV058</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGSLBV059">HGSLBV059</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMLBV066">HGMLBV066</a></td> </tr> <tr class="row-22"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFLBV067">HGFLBV067</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGALBV071">HGALBV071</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMLBV081">HGMLBV081</a></td> </tr> <tr class="row-23"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFLBV082">HGFLBV082</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN003 iPS1B">HGADFN003 iPS1B</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN003 iPS1C">HGADFN003 iPS1C</a></td> </tr> <tr class="row-24"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN003 iPS1D">HGADFN003 iPS1D</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN090 iPS1B">HGMDFN090 iPS1B</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGMDFN090 iPS1C">HGMDFN090 iPS1C</a></td> </tr> <tr class="row-25"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN167 iPS1J">HGADFN167 iPS1J</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGADFN167 iPS1Q">HGADFN167 iPS1Q</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFDFN168 iPS1D2">HGFDFN168 iPS1D2</a></td> </tr> <tr class="row-26"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#HGFDFN168 iPS1P">HGFDFN168 iPS1P</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#DNA">DNA</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#Autopsy tissue">Autopsy tissue</a></td> </tr> <tr class="row-27"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#Plasma">Plasma</a></td><td class="column-2"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#Serum">Serum</a></td><td class="column-3"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#Zokinvy">Zokinvy (lonafarnib)</a></td> </tr> <tr class="row-28"> <td class="column-1"><a href="https://www.progeriaresearch.org/prf-cell-and-tissue-bank-publications/#buffycoats">Buffy Coats</a></td><td class="column-2"></td><td class="column-3"></td> </tr> </tbody> </table> </h4> <p><strong>For publications listed by cell line inclusion, <a href="https://www.progeriaresearch.org/wp-content/uploads/2024/11/CTB-Publications-for-Website-11-25-24.pdf" target="_blank" rel="attachment noopener wp-att-15475">Click here.</a></strong></p> <p><strong>For publications listed by biological sample inclusion, <a href="https://www.progeriaresearch.org/wp-content/uploads/2024/04/Biological-materials-publications-4-10-24.pdf" target="_blank" rel="attachment noopener noreferrer wp-att-11278">Click here.</a></strong></p> <p><strong>For publications listed by Zokinvy (lonafarnib) inclusion, <a href="https://www.progeriaresearch.org/wp-content/uploads/2023/12/Lonafarnib-publications-12-12-23.pdf" target="_blank" rel="attachment noopener wp-att-12561">Click here.</a></strong></p></div> </div><div id="HGADFN001" class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN001</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21852285" target="_blank" rel="noopener noreferrer">Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.</a><br />Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. <em>J Gerontol A Biol Sci Med Sci</em>. 2011 Nov;66(11):1201-7.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18060063">The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.</a><br />McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. <em>PLoS One</em>. 2007 Dec 5;2(12):e1269.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16461887">Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.</a><br />McClintock D, Gordon LB, Djabali K. <em>Proc Natl Acad Sci U S A.</em> 2006 Feb 14;103(7):2154-9.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16650460">Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.</a><br />Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. <em>Mech Ageing Dev.</em> 2006 Aug;127(8):660-9.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16261260">Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.</a><br />Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. <em>Cell Mol Life Sci.</em> 2005 Nov;62(22):2669-78.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature.</em> 2003 May 15;423(6937):293-8.</p></div> </div><div id="HGADFN003" class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN003</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39456243/">Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts</a><br />Hartinger R, Singh K, Leverett J, Djabali K. <em>Biomolecules</em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390/biom14101310</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37858983/">Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome</a><br />Ferreira-Marques M, Carvalho A, Franco AC, et al. Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome [published online ahead of print, 2023 Oct 19]. <em>Aging Cell</em>. 2023;e13983. doi:10.1111/acel.13983</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37408186/">Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies</a><br />Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390/cells12101350</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37118121/" target="_blank" rel="noopener">Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.</a><br />Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36382717/" target="_blank" rel="noopener">Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice</a><br />Hu Q, Zhang N, Sui T, et al. [published online ahead of print, 2022 Nov 16]. <em>EMBO J</em>. 2022;e110937. doi:10.15252/embj.2022110937</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36139359/" target="_blank" rel="noopener">Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines</a><br />Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390/cells11182784</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36015093/">Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts</a><br />Vehns E, Arnold R, Djabali K. Pharmaceuticals (Basel). 2022;15(8):945. Published 2022 Jul 29. doi:10.3390/ph15080945</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36028501/">SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome</a><br />Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038/s41419-022-05168-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/35293271/">Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate</a><br />Pfeifer CR, Tobin MP, Cho S, et al. Nucleus. 2022;13(1):129-143. doi:10.1080/19491034.2022.2045726</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34471675/">Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome</a><br />Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, et al. <em>ACS Cent Sci</em>. 2021;7(8):1300-1310. doi:10.1021/acscentsci.0c01698</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34389865/">Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice</a><br />Mojiri A, Walther BK, Jiang C, et al. [published online ahead of print, 2021 Aug 14]. <em>Eur Heart J</em>. 2021;ehab547. doi:10.1093/eurheartj/ehab547</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34299092/">Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells</a><br />Arnold R, Vehns E, Randl H, Djabali K. <em>Int J Mol Sci</em>. 2021;22(14):7474. Published 2021 Jul 12. doi:10.3390/ijms22147474</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34202258/">Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells</a><br />Najdi F, Krüger P, Djabali K. <em>Cells</em>. 2021;10(7):1598. Published 2021 Jun 25. doi:10.3390/cells10071598</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33619770/">Self-assembly of multi-component mitochondrial nucleoids via phase separation.<br /></a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33466669/">Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.<br /></a>Röhrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390/cells10010153. PMID: 33466669; PMCID: PMC7828780.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31635416" target="_blank" rel="noopener noreferrer">Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells</a><br />Liu C, Arnold R, Henriques G, Djabali K. <em>Cells</em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390/cells8101276</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31385397" target="_blank" rel="noopener noreferrer">Analysis of Somatic Mutations Identifies Signs of Selection During in Vitro Aging of Primary Dermal Fibroblasts</a><br />Narisu N, Rothwell R, Vrtačnik P, et al. <em>Aging Cell</em> 2019;18(6):e13010. doi:10.1111/acel.13010</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em>. 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29690642" target="_blank" rel="noopener noreferrer">Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides</a><br />Lu X, Djabali K. <em>Cells</em> 2018;7(4):33. Published 2018 Apr 23. doi:10.3390/cells7040033</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30216637" target="_blank" rel="noopener noreferrer">Targeting the Phospholipase A2 Receptor Ameliorates Premature Aging Phenotypes</a><br />Griveau A, Wiel C, Le Calvé B, et al. <em>Aging Cell</em> 2018;17(6):e12835. doi:10.1111/acel.12835</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29466729" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29466729&source=gmail&ust=1521141690793000&usg=AFQjCNEm0UJMv9xcj0MeHXwuv16yQ3OkgA">A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.<br /></a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S. <em>Cell Rep</em>. 2018 Feb 20;22(8):2006-2015.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29361532" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29361532&source=gmail&ust=1517531320398000&usg=AFQjCNFid-5y_ASgPVuuRroqkATM6dg2eg">Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells.</a> Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242/jcs.208462. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29029393" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29029393&source=gmail&ust=1517531320399000&usg=AFQjCNHsEhIaQM5HyeO6zFC-zrw2VDhUNA">Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts. </a>Gabriel D, Shafry DD, Gordon LB, Djabali K. <em>Oncotarget</em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632/oncotarget.19363. eCollection 2017 Sep 12.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28033363/" target="_blank" rel="noopener noreferrer">Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.</a><br />Gabriel D, Gordon LB, Djabali K. <em>PLoS One</em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371/journal.pone.0168988</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27015553/" target="_blank" rel="noopener noreferrer">Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts </a><br />Eisch V, Lu X, Gabriel D, Djabali K. <em>Oncotarget</em> 2016;7(17):24700-24718. doi:10.18632/oncotarget.8267</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/28597562" target="_blank" rel="noopener noreferrer">Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.</a> Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Doré C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .<i>Aging Cell</i>. 2017 Jun 8. [Epub ahead of print]<a href="https://www.ncbi.nlm.nih.gov/pubmed/26922519">Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.</a> Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. <i>Aging</i> . 2016 Feb;8(2):366-81.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26922519" target="_blank" rel="noopener noreferrer">Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at</a> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26922519">serine 22 during interphase.</a><br />Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. <em>Aging</em> 2016 Feb;8(2):366-81.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27145372/" target="_blank" rel="noopener noreferrer">Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes</a><br />Kreienkamp R, Croke M, Neumann MA, et al. <em>Oncotarget</em> 2016;7(21):30018-30031. doi:10.18632/oncotarget.9065</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26549451" target="_blank" rel="noopener noreferrer">Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.</a> Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <i>Cell Rep</i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26443848">Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins.<br /></a>Vidak S, Kubben N, Dechat T, Foisner R. <i>Genes & Development.</i> 2015 Oct 1;29(19):2022-36.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/25510262">Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.<br /></a>Gabriel D, Roedl D, Gordon LB, Djabali K. <i>Aging Cell</i>. 2014 Dec 16: 1-14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.<i>Nat Commun</i>. 2013;4:1868.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23213444">Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.<br /></a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.<br /><em>Biol Open</em>. 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21852285">Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<br /></a>Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. <em>J Gerontol A Biol Sci Med Sci</em>. 2011 Nov;66(11):1201-7.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21670498">Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.</a><br />Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. <em>J Clin Invest.</em> 2011 Jul 1;121(7):2833-44</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/20559568">Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.</a><br />Marji J, O’Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. <em>PLoS One</em>. 2010 Jun 15;5(6):e11132.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/19958786">Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.</a><br />Viteri G, Chung YW, Stadtman ER. <em>Mech Ageing Dev</em>. 2010 Jan;131(1):2-8.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/19734887">Ageing-related chromatin defects through loss of the NURD complex.</a><br />Pegoraro G, Kubben N, Wickert U, Göhler H, Hoffmann K, Misteli T. <em>Nat Cell Biol.</em> 2009 Oct;11(10):1261-7.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18311132">Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.</a><br />Scaffidi P, Misteli T. <em>Nat Cell Biol. </em>2008 Apr;10(4):452-9.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18363904">Perturbation of wild-type lamin A metabolism results in a progeroid phenotype.</a><br />Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. <em>Aging Cell</em>. 2008 Jun;7(3):355-67</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/17360326">Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.</a><br />Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD.<em> Proc Natl Acad Sci USA</em>. 2007 Mar 20;104(12):4955-60.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18060063">The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.</a><br />McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. <em>PLoS One</em>. 2007 Dec 5;2(12):e1269.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/17360355">A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.</a><br />Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. <em>Proc Natl Acad Sci USA</em>. 2007 Mar 20;104(12):4949-54.</p> <p><a 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laminopathy-based premature aging.</a><br />Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. <em>Nat Med.</em> 2005 Jul;11(7):780-5.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16126733">Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.</a><br />Glynn MW, Glover TW. <em>Hum Mol Genet. </em>2005 Oct 15;14(20):2959-69.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/15184648">Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.</a><br />Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. <em>Proc Natl Acad Sci U S A</em><a title="Proceedings of the National Academy of Sciences of the 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PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32351002/" target="_blank" rel="noopener noreferrer">PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome</a><br />Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. <em>Aging Cell<br /></em><strong>Correction acknowledging PRF for cell lines is pending</strong></p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/28192606" target="_blank" rel="noopener noreferrer">Metformin Alleviates Aging Cellular Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.</a> Park SK, Shin OS. <i>Exp Dermatol</i>. 2017 Feb 13. [Epub ahead of print]<a href="https://www.ncbi.nlm.nih.gov/pubmed/26549451" target="_blank" rel="noopener noreferrer">Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.</a> Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <i>Cell Rep</i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26473290">Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.<br /></a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. <i>Oncotarget</i>. 2015 Oct 14. [Epub ahead of print]<a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. <i>Nat Commun</i>. 2013;4:1868.</p></div> </div><div id="HGADFN127" class="et_pb_module et_pb_text et_pb_text_10 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN127</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39456243/">Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts</a><br />Hartinger R, Singh K, Leverett J, Djabali K. <em>Biomolecules</em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390/biom14101310</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39096606/" target="_blank" rel="noopener">Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool</a><br />Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. <em>Comput Biol Med</em>. Published online August 2, 2024. doi:10.1016/j.compbiomed.2024.108970</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37210724/" target="_blank" rel="noopener">Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2</a><br />Vidak S, Serebryannyy LA, Pegoraro G, Misteli T. <em>Cell Rep</em>. 2023;42(5):112534. doi:10.1016/j.celrep.2023.112534</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37858983/">Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome</a><br />Ferreira-Marques M, Carvalho A, Franco AC, et al. Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome [published online ahead of print, 2023 Oct 19]. <em>Aging Cell</em>. 2023;e13983. doi:10.1111/acel.13983</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36743412/" target="_blank" rel="noopener">Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients</a><br />Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36139359/" target="_blank" rel="noopener">Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines</a><br />Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390/cells11182784</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36015093/">Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts</a><br />Vehns E, Arnold R, Djabali K. Pharmaceuticals (Basel). 2022;15(8):945. Published 2022 Jul 29. doi:10.3390/ph15080945</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36028501/">SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome</a><br />Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038/s41419-022-05168-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34299092/">Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells</a><br />Arnold R, Vehns E, Randl H, Djabali K. <em>Int J Mol Sci</em>. 2021;22(14):7474. Published 2021 Jul 12. doi:10.3390/ijms22147474</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34202258/">Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells</a><br />Najdi F, Krüger P, Djabali K. <em>Cells</em>. 2021;10(7):1598. Published 2021 Jun 25. doi:10.3390/cells10071598</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33619770/">Self-assembly of multi-component mitochondrial nucleoids via phase separation.<br /></a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33466669/">Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.<br /></a>Röhrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390/cells10010153. PMID: 33466669; PMCID: PMC7828780.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31635416" target="_blank" rel="noopener noreferrer">Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells</a><br />Liu C, Arnold R, Henriques G, Djabali K. <em>Cells</em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390/cells8101276</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29690642" target="_blank" rel="noopener noreferrer">Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides</a><br />Lu X, Djabali K. <em>Cells</em> 2018;7(4):33. Published 2018 Apr 23. doi:10.3390/cells7040033</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Al</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29029393" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29029393&source=gmail&ust=1517531320399000&usg=AFQjCNHsEhIaQM5HyeO6zFC-zrw2VDhUNA">Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts. </a>Gabriel D, Shafry DD, Gordon LB, Djabali K. <em>Oncotarget</em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632/oncotarget.19363. eCollection 2017 Sep 12.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28033363/" target="_blank" rel="noopener noreferrer">Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.</a><br />Gabriel D, Gordon LB, Djabali K. <em>PLoS One</em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371/journal.pone.0168988</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27015553/" target="_blank" rel="noopener noreferrer">Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts</a><br />Eisch V, Lu X, Gabriel D, Djabali K. <em>Oncotarget</em> 2016;7(17):24700-24718. doi:10.18632/oncotarget.8267</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/28192606" target="_blank" rel="noopener noreferrer">Metformin Alleviates Aging Cellular Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.</a> Park SK, Shin OS. <i>Exp Dermatol</i>. 2017 Feb 13. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26473290" target="_blank" rel="noopener noreferrer">Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.<br /></a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. <i>Oncotarget</i>. 2015 Oct 14. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/25510262" target="_blank" rel="noopener noreferrer">Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.<br /></a>Gabriel D, Roedl D, Gordon LB, Djabali K. <i>Aging Cell</i>. 2014 Dec 16: 1-14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22210539">A proteomic study of Hutchinson-Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease.<br /></a>Wang L, Yang W, Ju W, Wang P, Zhao X, Jenkins EC, Brown WT, Zhong N. <i>Biochem Biophys Res Commun.</i> 2012 Jan 27;417(4):1119-26. Epub 2011 Dec 24.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21852285">Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.</a><br />Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. <em>J Gerontol A Biol Sci Med Sci</em>. 2011 Nov;66(11):1201-7.<strong><br /></strong></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21504799">CTP:phosphocholine cytidylyltransferase α (CCTα) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.</a><br />Gehrig K, Ridgway ND. <em>Biochim Biophys Acta</em>. 2011 Jun;1811(6):377-85.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/20559568">Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.</a><br />Marji J, O’Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. <em>PLoS One</em>. 2010 Jun 15;5(6):e11132.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18331619">Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.</a><br />Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. <em>Aging Cell.</em> 2008 Jun;7(3):383-93.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/17360326">Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.</a><br />Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD.<em> Proc Natl Acad Sci USA</em>. 2007 Mar 20;104(12):4955-60.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18060063">The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.</a><br />McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. <em>PLoS One</em>. 2007 Dec 5;2(12):e1269.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16650460">Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.</a><br />Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. <em>Mech Ageing Dev</em><a title="Mechanisms of ageing and development." href="https://www.ncbi.nlm.nih.gov/pubmed/16650460"><em>.</em></a> 2006 Aug;127(8):660-9</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16461887">Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.</a><br />McClintock D, Gordon LB, Djabali K. <em>Proc Natl Acad Sci U S A.</em> 2006 Feb 14;103(7):2154-9.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16261260">Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.</a><br />Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. <em>Cell Mol Life Sci.</em> 2005 Nov;62(22):2669-78.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/15980864">Genomic instability in laminopathy-based premature aging.</a><br />Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. <em>Nat Med.</em> 2005 Jul;11(7):780-5.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16248985">Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C.</a><br />Zhong N, Radu G, Ju W, Brown WT<em>. Biochem Biophys Res Commun. </em>2005 Dec 16;338(2):855-61.</p></div> </div><div id="HGADFN136" class="et_pb_module et_pb_text et_pb_text_11 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN136</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16126733">Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.</a><br />Glynn MW, Glover TW. <em>Hum Mol Genet. </em>2005 Oct 15;14(20):2959-69.</p></div> </div><div id="HGADFN143" class="et_pb_module et_pb_text et_pb_text_12 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN143</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34471675/">Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome</a><br />Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, et al. <em>ACS Cent Sci</em>. 2021;7(8):1300-1310. doi:10.1021/acscentsci.0c01698</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32351002/" target="_blank" rel="noopener noreferrer">PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome</a><br />Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. <em>Aging Cell</em>.<br /><strong>Correction acknowledging PRF for cell lines is pending</strong></p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662" target="_blank" rel="noopener noreferrer">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.<i> Nat Commun</i>. 2013;4:1868.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21504799">CTP:phosphocholine cytidylyltransferase α (CCTα) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.</a><br />Gehrig K, Ridgway ND. <em>Biochim Biophys Acta.</em> 2011 Jun;1811(6):377-85.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18331619">Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.</a><br />Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. <em>Aging Cell.</em> 2008 Jun;7(3):383-93.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18060063">The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.</a><br />McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. <em>PLoS One</em>. 2007 Dec 5;2(12):e1269.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16461887">Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.</a><br />McClintock D, Gordon LB, Djabali K. <em>Proc Natl Acad Sci U S A.</em> 2006 Feb 14;103(7):2154-9.</p></div> </div><div id="HGADFN155" class="et_pb_module et_pb_text et_pb_text_13 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN155</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39422121/">Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature</a><br />Vakili S, Izydore EK, Losert L, et al. <em>Aging Cell</em>. Published online October 18, 2024. doi:10.1111/acel.14375</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39192596/">The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice</a><br />Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. <em>Aging Cell</em>. Published online August 27, 2024. doi:10.1111/acel.14272</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34448355/">Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria</a><br />González-Dominguez A, Montañez R, Castejón-Vega B, et al. [published online ahead of print, 2021 Aug 27]. <em>EMBO Mol Med</em>. 2021;e14012. doi:10.15252/emmm.202114012</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med.</em> 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32351002/" target="_blank" rel="noopener noreferrer">PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome</a><br />Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. <em>Aging Cell</em>.<br /><strong>Correction acknowledging PRF for cell lines is pending</strong></p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29690642" target="_blank" rel="noopener noreferrer">Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides</a><br />Lu X, Djabali K. <em>Cells</em> 2018;7(4):33. Published 2018 Apr 23. doi:10.3390/cells7040033</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29361532" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29361532&source=gmail&ust=1517531320399000&usg=AFQjCNHUha14x9DBN6rJU7Cq1hwU6vaT_w">Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells.</a> Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242/jcs.208462. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29029393" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29029393&source=gmail&ust=1517531320399000&usg=AFQjCNHsEhIaQM5HyeO6zFC-zrw2VDhUNA">Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts. </a>Gabriel D, Shafry DD, Gordon LB, Djabali K. <em>Oncotarget</em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632/oncotarget.19363. eCollection 2017 Sep 12.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28033363/" target="_blank" rel="noopener noreferrer">Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.</a><br />Gabriel D, Gordon LB, Djabali K. <em>PLoS One</em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371/journal.pone.0168988</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27015553/" target="_blank" rel="noopener noreferrer">Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts</a><br />Eisch V, Lu X, Gabriel D, Djabali K. <em>Oncotarget</em> 2016;7(17):24700-24718. doi:10.18632/oncotarget.8267</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26549451" target="_blank" rel="noopener noreferrer">Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.</a> Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <i>Cell Rep</i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26549451">Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<br /></a>Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <i>Cell Rep</i>. 2015 Nov 4. [Epub ahead of print]<a href="https://www.ncbi.nlm.nih.gov/pubmed/26443848">Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins.<br /></a>Vidak S, Kubben N, Dechat T, Foisner R. <i>Genes & Development.</i> 2015 Oct 1;29(19):2022-36.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/25510262">Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.<br /></a>Gabriel D, Roedl D, Gordon LB, Djabali K. <i>Aging Cell</i>. 2014 Dec 16: 1-14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/24344186">Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence.<br /></a>Swanson EC, Manning B, Zhang H, Lawrence JB. <i>J Cell Biol</i>. 2013 Dec 23;203(6):929-42.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23152449">Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.<br /></a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. <i>Genome</i> <i>Res</i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23596277">An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells.<br /></a>Xiong ZM, LaDana C, Wu D, Cao K. <i>Aging</i> (Albany NY). 2013 Apr;5(4):288-303.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.<i> Nat Commun</i>. 2013;4:1868.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22354768">Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell?<br /></a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. <i>Aging</i> (Albany NY). 2012 Feb;4(2):119-32.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21715679">Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.</a><br />Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. <em>Sci Transl Med.</em> 2011 Jun 29;3(89):89ra58.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/20559568">Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.</a><br />Marji J, O’Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. <em>PLoS One</em>. 2010 Jun 15;5(6):e11132.</p></div> </div><div id="HGADFN164" class="et_pb_module et_pb_text et_pb_text_14 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN164</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39456243/">Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts</a><br />Hartinger R, Singh K, Leverett J, Djabali K. <em>Biomolecules</em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390/biom14101310</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37408186/">Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies</a><br />Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390/cells12101350</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36139359/" target="_blank" rel="noopener">Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines</a><br />Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390/cells11182784</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33293552/">SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat </a><br />Sebestyén E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31635416" target="_blank" rel="noopener noreferrer">Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells</a><br />Liu C, Arnold R, Henriques G, Djabali K. <em>Cells</em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390/cells8101276</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31385397" target="_blank" rel="noopener noreferrer">Analysis of Somatic Mutations Identifies Signs of Selection During in Vitro Aging of Primary Dermal Fibroblasts</a><br />Narisu N, Rothwell R, Vrtačnik P, et al. <em>Aging Cell</em>. 2019;18(6):e13010. doi:10.1111/acel.13010</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30001457/" target="_blank" rel="noopener noreferrer">Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria</a><br />Choi JY, Lai JK, Xiong ZM, et al. <em>J Bone Miner Res</em> 2018;33(11):2059-2070. doi:10.1002/jbmr.3549</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29690642" target="_blank" rel="noopener noreferrer">Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides</a><br />Lu X, Djabali K. <em>Cells</em>. 2018;7(4):33. Published 2018 Apr 23. doi:10.3390/cells7040033</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29029393" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29029393&source=gmail&ust=1517531320399000&usg=AFQjCNHsEhIaQM5HyeO6zFC-zrw2VDhUNA">Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.</a>Gabriel D, Shafry DD, Gordon LB, Djabali K. <em>Oncotarget</em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632/oncotarget.19363. eCollection 2017 Sep 12.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28033363/" target="_blank" rel="noopener noreferrer">Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.</a><br />Gabriel D, Gordon LB, Djabali K. <em>PLoS One</em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371/journal.pone.0168988</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26549451" target="_blank" rel="noopener noreferrer">Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.</a> Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <i>Cell Rep</i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID: 26549451</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/25510262">Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.<br /></a>Gabriel D, Roedl D, Gordon LB, Djabali K. <i>Aging Cell</i>. 2014 Dec 16: 1-14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/24843141">Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.<br /></a>Zhang H, Xiong ZM, Cao K. <i>Proc Natl Acad Sci</i> U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23152449">Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.<br /></a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. <i>Genome</i> <i>Res</i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23596277">An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells.<br /></a>Xiong ZM, LaDana C, Wu D, Cao K. <i>Aging</i> (Albany NY). 2013 Apr;5(4):288-303.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.<i> Nat Commun</i>. 2013;4:1868.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23213444">Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.<br /></a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.<br /><i>Biol Open.</i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.</p> <p class="title1"><a href="https://www.ncbi.nlm.nih.gov/pubmed/20559568">Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.</a>Marji J, O’Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. <i>PLoS One</i>. 2010 Jun 15;5(6):e11132.</p></div> </div><div id="HGADFN167" class="et_pb_module et_pb_text et_pb_text_15 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN167</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39422121/">Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature</a><br />Vakili S, Izydore EK, Losert L, et al. <em>Aging Cell</em>. Published online October 18, 2024. doi:10.1111/acel.14375</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39211333/">Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms</a><br />Yu R, Xue H, Lin W, Collins FS, Mount SM, Cao K. <em>NAR Genom Bioinform</em>. 2024;6(3):lqae115. Published 2024 Aug 29. doi:10.1093/nargab/lqae115</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38948754/" target="_blank" rel="noopener">Coaching ribosome biogenesis from the nuclear periphery</a><br />Zhuang Y, Guo X, Razorenova OV, Miles CE, Zhao W, Shi X. bioRxiv [Preprint]. 2024 Jun 22:2024.06.21.597078. doi: 10.1101/2024.06.21.597078. PMID: 38948754; PMCID: PMC11212990.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37210724/" target="_blank" rel="noopener">Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2</a><br />Vidak S, Serebryannyy LA, Pegoraro G, Misteli T. <em>Cell Rep</em>. 2023;42(5):112534. doi:10.1016/j.celrep.2023.112534</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37572165/">Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T</a><br />Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. <em>Cell Tissue Res</em>. 2023;10.1007/s00441-023-03813-2. doi:10.1007/s00441-023-03813-2</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37118121/" target="_blank" rel="noopener">Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.</a><br />Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36977745/" target="_blank" rel="noopener">Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.</a><br />Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038/s41598-023-32035-3. PMID: 36977745; PMCID: PMC10050176.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36579892/" target="_blank" rel="noopener">Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification</a><br />San Martin R, Das P, Sanders JT, Hill AM, McCord RP. [published online ahead of print, 2022 Dec 29]. <em>Elife</em>. 2022;11:e81290. doi:10.7554/eLife.81290</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36522352/" target="_blank" rel="noopener">Achieving single nucleotide sensitivity in direct hybridization genome imaging</a><br />Wang Y, Cottle WT, Wang H, et al. <em>Nat Commun</em>. 2022;13(1):7776. Published 2022 Dec 15. doi:10.1038/s41467-022-35476-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36382717/" target="_blank" rel="noopener">Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice</a><br />Hu Q, Zhang N, Sui T, et al. [published online ahead of print, 2022 Nov 16]. <em>EMBO J</em>. 2022;e110937. doi:10.15252/embj.2022110937</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36233036/" target="_blank" rel="noopener">Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry</a><br />Camafeita E, Jorge I, Rivera-Torres J, Andrés V, Vázquez J. Int J Mol Sci. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390/ijms231911733</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36096808/">Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP</a><br />La Torre M, Merigliano C, Maccaroni K, et al. <em>J Exp Clin Cancer Res</em>. 2022;41(1):273. Published 2022 Sep 13. doi:10.1186/s13046-022-02480-5</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36028501/">SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome</a><br />Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038/s41419-022-05168-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/35628310/" target="_blank" rel="noopener">Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome</a><br />Mao X, Xiong ZM, Xue H, et al. Int J Mol Sci. 2022;23(10):5499. Published 2022 May 14. doi:10.3390/ijms23105499</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34471675/">Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome</a><br />Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, et al. <em>ACS Cent Sci</em>. 2021;7(8):1300-1310. doi:10.1021/acscentsci.0c01698</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34389865/">Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice</a><br />Mojiri A, Walther BK, Jiang C, et al. [published online ahead of print, 2021 Aug 14]. <em>Eur Heart J</em>. 2021;ehab547. doi:10.1093/eurheartj/ehab547</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34086398/">Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.</a><br />Gete YG, Koblan LW, Mao X, Trappio M, Mahadik B, Fisher JP, Liu DR, Cao K. Aging Cell. 2021 Jun 4:e13388. doi: 10.1111/acel.13388. Epub ahead of print. PMID: 34086398.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33707773/">A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<br /></a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33408413/">In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.<br /></a>Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR. Nature. 2021 Jan;589(7843):608-614. doi: 10.1038/s41586-020-03086-7. Epub 2021 Jan 6. PMID: 33408413; PMCID: PMC7872200.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33619770/">Self-assembly of multi-component mitochondrial nucleoids via phase separation.<br /></a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33293552/">SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat </a><br />Sebestyén E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038/s41467-020-20048-9. 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Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32032552" target="_blank" rel="noopener noreferrer">iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome</a><br />Atchison L, Abutaleb NO, Snyder-Mounts E, et al. <em>Stem Cell Reports</em> 2020;14(2):325‐337. doi:10.1016/j.stemcr.2020.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32320674/" target="_blank" rel="noopener noreferrer">Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells</a><br />Lionetti MC, Bonfanti S, Fumagalli MR, Budrikis Z, Font-Clos F, Costantini G, Chepizhko O, Zapperi S, La Porta CAM. <em>Biophysical Journal</em> 2020 May 5;118(9):2319-2332.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32208162" target="_blank" rel="noopener noreferrer">Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria</a><br />Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. <em>Dev Cell</em> 2020;52(6):699‐713.e11. doi:10.1016/j.devcel.2020.02.011</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32186522" target="_blank" rel="noopener noreferrer">Peroxisomal Abnormalities and Catalase Deficiency in Hutchinson-Gilford Progeria Syndrome</a><br />Mao X, Bharti P, Thaivalappil A, Cao K. <em>Aging</em> (Albany NY) 2020;12(6):5195‐5208. doi:10.18632/aging.102941</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31287964" target="_blank" rel="noopener noreferrer">Restoring Extracellular Matrix Synthesis in Senescent Stem Cells</a><br />Rong N, Mistriotis P, Wang X, et al. <em>FASEB J</em>. 2019;33(10):10954‐10965. doi:10.1096/fj.201900377R</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30808750" target="_blank" rel="noopener noreferrer">Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging</a><br />Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG. <em>Proc Natl Acad Sci U S A</em> 2019;116(9):3578‐3583. doi:10.1073/pnas.1809683116</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. 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Published online October 18, 2024. doi:10.1111/acel.14375</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39211333/">Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms</a><br />Yu R, Xue H, Lin W, Collins FS, Mount SM, Cao K. <em>NAR Genom Bioinform</em>. 2024;6(3):lqae115. Published 2024 Aug 29. doi:10.1093/nargab/lqae115</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37210724/" target="_blank" rel="noopener">Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2</a><br />Vidak S, Serebryannyy LA, Pegoraro G, Misteli T. <em>Cell Rep</em>. 2023;42(5):112534. doi:10.1016/j.celrep.2023.112534</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37572165/">Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T</a><br />Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. <em>Cell Tissue Res</em>. 2023;10.1007/s00441-023-03813-2. doi:10.1007/s00441-023-03813-2</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37118121/" target="_blank" rel="noopener">Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.</a><br />Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36977745/" target="_blank" rel="noopener">Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.</a><br />Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038/s41598-023-32035-3. 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Published 2022 Oct 3. doi:10.3390/ijms231911733</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/35628310/" target="_blank" rel="noopener">Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome</a><br />Mao X, Xiong ZM, Xue H, et al. Int J Mol Sci. 2022;23(10):5499. Published 2022 May 14. doi:10.3390/ijms23105499</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34471675/">Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome</a><br />Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, et al. <em>ACS Cent Sci</em>. 2021;7(8):1300-1310. doi:10.1021/acscentsci.0c01698</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34389865/">Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice</a><br />Mojiri A, Walther BK, Jiang C, et al. [published online ahead of print, 2021 Aug 14]. <em>Eur Heart J</em>. 2021;ehab547. doi:10.1093/eurheartj/ehab547</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34086398/">Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.</a><br />Gete YG, Koblan LW, Mao X, Trappio M, Mahadik B, Fisher JP, Liu DR, Cao K. Aging Cell. 2021 Jun 4:e13388. doi: 10.1111/acel.13388. Epub ahead of print. PMID: 34086398.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33707773/">A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<br /></a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33408413/">In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.<br /></a>Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR. Nature. 2021 Jan;589(7843):608-614. doi: 10.1038/s41586-020-03086-7. Epub 2021 Jan 6. PMID: 33408413; PMCID: PMC7872200.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33619770/">Self-assembly of multi-component mitochondrial nucleoids via phase separation.<br /></a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23. 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Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32186522" target="_blank" rel="noopener noreferrer">Peroxisomal Abnormalities and Catalase Deficiency in Hutchinson-Gilford Progeria Syndrome</a><br />Mao X, Bharti P, Thaivalappil A, Cao K. <em>Aging</em> (Albany NY) 2020;12(6):5195‐5208. doi:10.18632/aging.102941</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32032552" target="_blank" rel="noopener noreferrer">iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome</a>Atchison L, Abutaleb NO, Snyder-Mounts E, et al. <em>Stem Cell Reports</em> 2020;14(2):325‐337. doi:10.1016/j.stemcr.2020.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31287964" target="_blank" rel="noopener noreferrer">Restoring Extracellular Matrix Synthesis in Senescent Stem Cells</a><br />Rong N, Mistriotis P, Wang X, et al. <em>FASEB J</em>. 2019;33(10):10954‐10965. doi:10.1096/fj.201900377R</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30808750" target="_blank" rel="noopener noreferrer">Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging</a><br />Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG. <em>Proc Natl Acad Sci U S A</em> 2019;116(9):3578‐3583. doi:10.1073/pnas.1809683116</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30001457/" target="_blank" rel="noopener noreferrer">Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria</a><br />Choi JY, Lai JK, Xiong ZM, et al. <em>J Bone Miner Res</em> 2018;33(11):2059-2070. doi:10.1002/jbmr.3549</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29581305" target="_blank" rel="noopener noreferrer">Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts</a><br />DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A 2018 Apr 16;:]. <em>Proc Natl Acad Sci U S A</em>. 2018;115(16):4206‐4211. doi:10.1073/pnas.1802811115</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29405587" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29405587&source=gmail&ust=1521141690793000&usg=AFQjCNHpgREghY1BQk-aP_SQhyw8YR1GWg">Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.<br /></a>Borroni AP, Emanuelli A, Shah PA, Ilić N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M. <em>Aging Cell</em>. 2018 Feb 5. doi: 10.1111/acel.12732. [Epub ahead of print].</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29361532" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29361532&source=gmail&ust=1517531320400000&usg=AFQjCNGoYbmkMeurGAPE_yfCAUSex6Sg_A">Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells.</a> Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242/jcs.208462. [Epub ahead of print]<a href="https://www.ncbi.nlm.nih.gov/pubmed/28855503" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/28855503&source=gmail&ust=1517531320400000&usg=AFQjCNGgE7vflWBAHswb_MZKkFd0I5gfWQ">Nucleolar expansion and elevated protein translation in premature aging.</a> Buchwalter A, Hetzer MW. Nat Commun. 2017 Aug 30;8(1):328. doi: 10.1038/s41467-017-00322-z.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/28597562" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/28597562&source=gmail&ust=1517531320400000&usg=AFQjCNEQEuB2ZzRJ8EQiUgrjiVi2otzOAg">Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape. </a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Doré C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .<em>Aging Cell</em>. 2017 Jun 8. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27907109" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/27907109&source=gmail&ust=1517531320400000&usg=AFQjCNGC7AjWVW1mCKlG-pAT-AUqoU-e-w">Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.</a> Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, Cao K. <em>PLoS One</em>. 2016 Dec 1;11(12):e0167454. doi: 10.1371/journal.pone.0167454.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27350449" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/27350449&source=gmail&ust=1517531320400000&usg=AFQjCNFzFqP9zLIU0d_qFN_oc-DDb3rKgw">NANOG reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.</a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST. <em>Stem Cells</em>. 2016 Jun 28. doi: 10.1002/stem.2452. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26663466" target="_blank" rel="noopener noreferrer">Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.<br /></a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. <a title="Aging cell." href="https://www.ncbi.nlm.nih.gov/pubmed/26663466"><i>Aging Cell.</i></a> 2015 Dec 14. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26443848" target="_blank" rel="noopener noreferrer">Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins.<br /></a>Vidak S, Kubben N, Dechat T, Foisner R. <i>Genes & Development.</i> 2015 Oct 1;29(19):2022-36.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26171741">Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force.<br /></a>Booth EA, Spagnol ST, Alcoser TA, Dahl KN. <i>Soft Matter</i>. 2015 Aug 28;11(32):6412-8. Epub 2015 Jul 14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26357076">Phenotype-Dependent Coexpression Gene Clusters: Application to Normal and Premature Ageing.<br /></a>Wang K, Das A, Xiong Z, Cao K, Hannenhalli S. <i>IEEE/ACM Trans Comput Biol Bioinform</i> 2015 Jan-Feb;12(1):30-9.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/24843141">Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.<br /></a>Zhang H, Xiong ZM, Cao K. <i>Proc Natl Acad Sci</i> U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23152449">Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.<br /></a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. <i>Genome</i> <i>Res</i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22354768">Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell?<br /></a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. <i>Aging</i> (Albany NY). 2012 Feb;4(2):119-32.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22127259">Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.<br /></a>Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. <i>Nucleus</i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21715679">Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.</a><br />Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. <em>Sci Transl Med.</em> 2011 Jun 29;3(89):89ra58.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21670498">Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.</a><br />Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. <em>J Clin Invest</em><em>.</em> 2011 Jul 1;121(7):2833-44</p> <p class="title10"><a href="https://www.ncbi.nlm.nih.gov/pubmed/19958786">Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.</a><br />Viteri G, Chung YW, Stadtman ER. <em>Mech Ageing Dev</em>. 2010 Jan;131(1):2-8.</p> <p class="title10"><a href="https://www.ncbi.nlm.nih.gov/pubmed/17360355">A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.</a><br />Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. <em>Proc Natl Acad Sci USA</em>. 2007 Mar 20;104(12):4949-54.</p></div> </div><div id="HGADFN169" class="et_pb_module et_pb_text et_pb_text_17 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN169</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39096606/" target="_blank" rel="noopener">Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool</a><br />Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. <em>Comput Biol Med</em>. Published online August 2, 2024. doi:10.1016/j.compbiomed.2024.108970</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36743412/" target="_blank" rel="noopener">Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients</a><br />Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36028501/">SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome</a><br />Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038/s41419-022-05168-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33293552/">SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat </a><br />Sebestyén E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32351002/" target="_blank" rel="noopener noreferrer">PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome</a><br />Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. <em>Aging Cell</em>.<br /><strong>Correction acknowledging PRF for cell lines is pending</strong></p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26663466" target="_blank" rel="noopener noreferrer">Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.<br /></a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. <a title="Aging cell." href="https://www.ncbi.nlm.nih.gov/pubmed/26663466"><i>Aging Cell.</i></a> 2015 Dec 14. [Epub ahead of print]</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/26549451" target="_blank" rel="noopener noreferrer">Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.</a> Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <i>Cell Rep</i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23152449">Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.<br /></a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. <i>Genome</i> <i>Res</i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.<i> Nat Commun</i>. 2013;4:1868.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21715679">Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<br /></a>[sta_anchor id=”fn178″ unsan=”FN178″]Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. <i>Sci Transl Med.</i> 2011 Jun 29;3(89):89ra58.</p></div> </div><div id="HGADFN178" class="et_pb_module et_pb_text et_pb_text_18 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><b>HGADFN178</b></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37217561/" target="_blank" rel="noopener">Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models</a><br />Zonari A, Brace LE, Al-Katib K, et al. 2024 Feb 15;10(1):14]. <em>NPJ Aging</em>. 2023;9(1):10. Published 2023 May 22. doi:10.1038/s41514-023-00109-1</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37210724/" target="_blank" rel="noopener">Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2</a><br />Vidak S, Serebryannyy LA, Pegoraro G, Misteli T. <em>Cell Rep</em>. 2023;42(5):112534. doi:10.1016/j.celrep.2023.112534</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37408186/">Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies</a><br />Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390/cells12101350</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36139359/" target="_blank" rel="noopener">Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines</a><br />Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390/cells11182784</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36233036/" target="_blank" rel="noopener">Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry</a><br />Camafeita E, Jorge I, Rivera-Torres J, Andrés V, Vázquez J. Int J Mol Sci. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390/ijms231911733</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33619770/">Self-assembly of multi-component mitochondrial nucleoids via phase separation.<br /></a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33466669/">Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.<br /></a>Röhrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390/cells10010153. PMID: 33466669; PMCID: PMC7828780.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28515154/" target="_blank" rel="noopener noreferrer">Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes</a><br />Hilton BA, Liu J, Cartwright BM</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23213444">Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.<br /></a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.<br /><i>Biol Open.</i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.</p></div> </div><div id="HGADFN188" class="et_pb_module et_pb_text et_pb_text_19 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN188</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39096606/" target="_blank" rel="noopener">Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool</a><br />Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. <em>Comput Biol Med</em>. Published online August 2, 2024. doi:10.1016/j.compbiomed.2024.108970</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36743412/" target="_blank" rel="noopener">Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients</a><br />Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36139359/" target="_blank" rel="noopener">Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines</a><br />Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390/cells11182784</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36028501/">SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome</a><br />Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038/s41419-022-05168-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33466669/">Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.<br /></a>Röhrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390/cells10010153. PMID: 33466669; PMCID: PMC7828780.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33293552/">SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat </a><br />Sebestyén E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em> 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31635416" target="_blank" rel="noopener noreferrer">Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells</a><br />Liu C, Arnold R, Henriques G, Djabali K. <em>Cells</em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390/cells8101276</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31385397" target="_blank" rel="noopener noreferrer">Analysis of Somatic Mutations Identifies Signs of Selection During in Vitro Aging of Primary Dermal Fibroblasts</a><br />Narisu N, Rothwell R, Vrtačnik P, et al. <em>Aging Cell</em> 2019;18(6):e13010. doi:10.1111/acel.13010</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29429991" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29429991&source=gmail&ust=1521141690793000&usg=AFQjCNF8BKf4JqEBkbNldIYDkATIv5FVvQ">p53 isoforms regulate premature aging in human cells.<br /></a>von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC.<br /><em>Oncogene</em>. 2018 Feb 12. doi: 10.1038/s41388-017-0101-3. [Epub ahead of print]</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28033363/" target="_blank" rel="noopener noreferrer">Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.</a><br />Gabriel D, Gordon LB, Djabali K. <em>PLoS One</em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371/journal.pone.0168988</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27015553/" target="_blank" rel="noopener noreferrer">Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts</a><br />Eisch V, Lu X, Gabriel D, Djabali K. <em>Oncotarget</em> 2016;7(17):24700-24718. doi:10.18632/oncotarget.8267</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/25510262" target="_blank" rel="noopener noreferrer">Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.<br /></a>Gabriel D, Roedl D, Gordon LB, Djabali K. <i>Aging Cell</i>. 2014 Dec 16: 1-14.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695662">Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.<br /></a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.<i> Nat Commun</i>. 2013;4:1868.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/23213444">Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.<br /></a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.<br /><i>Biol Open.</i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.</p> <p class="title10"><a href="https://www.ncbi.nlm.nih.gov/pubmed/20559568">Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.</a><br />Marji J, O’Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. <em>PLoS One</em>. 2010 Jun 15;5(6):e11132.</p></div> </div><div id="HGADFN271" class="et_pb_module et_pb_text et_pb_text_20 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN271</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39456243/">Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts</a><br />Hartinger R, Singh K, Leverett J, Djabali K. <em>Biomolecules</em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390/biom14101310</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39096606/" target="_blank" rel="noopener">Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool</a><br />Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. <em>Comput Biol Med</em>. Published online August 2, 2024. doi:10.1016/j.compbiomed.2024.108970</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36743412/" target="_blank" rel="noopener">Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients</a><br />Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33293552/">SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat </a><br />Sebestyén E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32450911/" target="_blank" rel="noopener noreferrer">Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome</a><br />Köhler F, Bormann F, Raddatz G, et al. <em>Genome Med</em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186/s13073-020-00749-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="HGADFN367" class="et_pb_module et_pb_text et_pb_text_21 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN367</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39192596/">The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice</a><br />Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. <em>Aging Cell</em>. Published online August 27, 2024. doi:10.1111/acel.14272</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39096606/" target="_blank" rel="noopener">Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool</a><br />Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. <em>Comput Biol Med</em>. Published online August 2, 2024. doi:10.1016/j.compbiomed.2024.108970</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37572165/">Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T</a><br />Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. <em>Cell Tissue Res</em>. 2023;10.1007/s00441-023-03813-2. doi:10.1007/s00441-023-03813-2</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36743412/" target="_blank" rel="noopener">Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients</a><br />Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36028501/">SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome</a><br />Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038/s41419-022-05168-y</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34448355/">Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria</a><br />González-Dominguez A, Montañez R, Castejón-Vega B, et al. [published online ahead of print, 2021 Aug 27]. <em>EMBO Mol Med</em>. 2021;e14012. doi:10.15252/emmm.202114012</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33707773/">A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<br /></a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30567591/" target="_blank" rel="noopener noreferrer">Predicting Age From the Transcriptome of Human Dermal Fibroblasts</a><br />Fleischer JG, Schulte R, Tsai HH, et al. <em>Genome Biol</em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186/s13059-018-1599-6</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="HGMDFN368" class="et_pb_module et_pb_text et_pb_text_22 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGMDFN368</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39456243/">Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts</a><br />Hartinger R, Singh K, Leverett J, Djabali K. <em>Biomolecules</em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390/biom14101310</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39192596/">The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice</a><br />Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. <em>Aging Cell</em>. Published online August 27, 2024. doi:10.1111/acel.14272</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37572165/">Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T</a><br />Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. <em>Cell Tissue Res</em>. 2023;10.1007/s00441-023-03813-2. doi:10.1007/s00441-023-03813-2</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34448355/">Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria</a><br />González-Dominguez A, Montañez R, Castejón-Vega B, et al. [published online ahead of print, 2021 Aug 27]. <em>EMBO Mol Med</em>. 2021;e14012. doi:10.15252/emmm.202114012</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33707773/">A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<br /></a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494" target="_blank" rel="noopener noreferrer">Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="HGFDFN369" class="et_pb_module et_pb_text et_pb_text_23 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGFDFN369</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/39456243/">Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts</a><br />Hartinger R, Singh K, Leverett J, Djabali K. <em>Biomolecules</em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390/biom14101310</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37572165/">Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T</a>Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. <em>Cell Tissue Res</em>. 2023;10.1007/s00441-023-03813-2. doi:10.1007/s00441-023-03813-2</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Agi</em></p></div> </div><div id="HGADFN370" class="et_pb_module et_pb_text et_pb_text_24 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN370</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30808750" target="_blank" rel="noopener noreferrer">Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging</a><br />Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG. <em>Proc Natl Acad Sci U S A</em>. 2019;116(9):3578‐3583. doi:10.1073/pnas.1809683116</p></div> </div><div id="HGMDFN371" class="et_pb_module et_pb_text et_pb_text_25 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGMDFN371</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30808750" target="_blank" rel="noopener noreferrer">Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging</a><br />Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG. <em>Proc Natl Acad Sci U S A</em>. 2019;116(9):3578‐3583. doi:10.1073/pnas.1809683116</p></div> </div><div id="HGADFN496" class="et_pb_module et_pb_text et_pb_text_26 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN496</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33707773/">A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<br /></a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.</p></div> </div><div id="HGMDFN717" class="et_pb_module et_pb_text et_pb_text_27 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGMDFN717</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37572165/">Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T</a><br />Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. <em>Cell Tissue Res</em>. 2023;10.1007/s00441-023-03813-2. doi:10.1007/s00441-023-03813-2</p></div> </div><div id="HGMDFN718" class="et_pb_module et_pb_text et_pb_text_28 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGMDFN718</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/33707773/">A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<br /></a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.</p></div> </div><div id="PSADFN086" class="et_pb_module et_pb_text et_pb_text_29 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN086<br /></strong><u>(formally HGADFN086)</u></h4> <p><strong> </strong><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY).</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/17469202" target="_blank" rel="noopener noreferrer">Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.</a><br />Moulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH. <em>Hum Mutat.</em> 2007 Sep;28(9):882-9.</p></div> </div><div id="PSADFN257" class="et_pb_module et_pb_text et_pb_text_30 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN257</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29466729" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29466729&source=gmail&ust=1521207589179000&usg=AFQjCNEZOPxztHCOyegfZx6eLyqAAgdZhA">A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.<br /></a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S. <em>Cell Rep</em>. 2018 Feb 20;22(8):2006-2015.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27145372/" target="_blank" rel="noopener noreferrer">Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes</a><br />Kreienkamp R, Croke M, Neumann MA, et al. <em>Oncotarget</em> 2016;7(21):30018-30031. doi:10.18632/oncotarget.9065</p></div> </div><div id="PSADFN317" class="et_pb_module et_pb_text et_pb_text_31 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN317</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37408186/">Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies</a><br />Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390/cells12101350</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="PSADFN318" class="et_pb_module et_pb_text et_pb_text_32 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN318</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37408186/">Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies</a><br />Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390/cells12101350</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="PSFDFN319" class="et_pb_module et_pb_text et_pb_text_33 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSFDFN319</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21715679">Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.</a><br />Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. <em>Sci Transl Med.</em> 2011 Jun 29;3(89):89ra58.</p></div> </div><div id="PSMDFN320" class="et_pb_module et_pb_text et_pb_text_34 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSMDFN320</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM,</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21715679" target="_blank" rel="noopener noreferrer">Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.</a><br />Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. <em>Sci Transl Med.</em> 2011 Jun 29;3(89):89ra58.</p></div> </div><div id="PSMDFN326" class="et_pb_module et_pb_text et_pb_text_35 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSMDFN326</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="PSFDFN327" class="et_pb_module et_pb_text et_pb_text_36 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSFDFN327</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29466729" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29466729&source=gmail&ust=1521207589179000&usg=AFQjCNEZOPxztHCOyegfZx6eLyqAAgdZhA">A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.<br /></a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S. <em>Cell Rep</em>. 2018 Feb 20;22(8):2006-2015.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27145372/" target="_blank" rel="noopener noreferrer">Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes</a><br />Kreienkamp R, Croke M, Neumann MA, et al. <em>Oncotarget</em> 2016;7(21):30018-30031. doi:10.18632/oncotarget.9065</p></div> </div><div id="PSMDFN346" class="et_pb_module et_pb_text et_pb_text_37 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSMDFN346</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29466729" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29466729&source=gmail&ust=1521207589179000&usg=AFQjCNEZOPxztHCOyegfZx6eLyqAAgdZhA">A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.<br /></a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S. <em>Cell Rep</em>. 2018 Feb 20;22(8):2006-2015.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27145372/" target="_blank" rel="noopener noreferrer">Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes</a><br />Kreienkamp R, Croke M, Neumann MA, et al. <em>Oncotarget</em> 2016;7(21):30018-30031. doi:10.18632/oncotarget.9065</p></div> </div><div id="PSADFN363" class="et_pb_module et_pb_text et_pb_text_38 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN363</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38050983/">The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B</a><br />Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. <em>Nucleus</em>. 2023;14(1):2288476. doi:10.1080/19491034.2023.2288476</p></div> </div><div id="PSADFN373" class="et_pb_module et_pb_text et_pb_text_39 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN373</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32910507/">Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency</a><br />Yao H, Chen X, Kashif M, Wang T, Ibrahim MX, Tüksammel E, Revêchon G, Eriksson M, Wiel C, Bergo MO. Aging Cell. 2020 Aug;19(8):e13200. doi: 10.1111/acel.13200. Epub 2020 Jul 24. PMID: 32910507; PMCID: PMC7431821.</p></div> </div><div id="PSADFN392" class="et_pb_module et_pb_text et_pb_text_40 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN392</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a><br />Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29466729" target="_blank" rel="noopener noreferrer" data-saferedirecturl="https://www.google.com/url?hl=en&q=https://www.ncbi.nlm.nih.gov/pubmed/29466729&source=gmail&ust=1521207589179000&usg=AFQjCNEZOPxztHCOyegfZx6eLyqAAgdZhA">A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.<br /></a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S. <em>Cell Rep</em>. 2018 Feb 20;22(8):2006-2015.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27145372/" target="_blank" rel="noopener noreferrer">Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes</a><br />Kreienkamp R, Croke M, Neumann MA, et al. <em>Oncotarget</em> 2016;7(21):30018-30031. doi:10.18632/oncotarget.9065</p></div> </div><div id="PSADFN423" class="et_pb_module et_pb_text et_pb_text_41 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN423</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a><br />Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p></div> </div><div id="PSADFN485" class="et_pb_module et_pb_text et_pb_text_42 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center">PSADFN485</h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38050983/">The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B</a><br />Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. <em>Nucleus</em>. 2023;14(1):2288476. doi:10.1080/19491034.2023.2288476</p></div> </div><div id="PSADFN542" class="et_pb_module et_pb_text et_pb_text_43 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center">PSADFN542</h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38050983/">The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B</a><br />Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. <em>Nucleus</em>. 2023;14(1):2288476. doi:10.1080/19491034.2023.2288476</p></div> </div><div id="PSADFN386" class="et_pb_module et_pb_text et_pb_text_44 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN386</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a><br />Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/35203262/" target="_blank" rel="noopener">MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells</a><br />Harhouri K, Cau P, Casey F, et al. <em>Cells</em>. 2022;11(4):610. Published 2022 Feb 10. doi:10.3390/cells11040610</p></div> </div><div id="PSMDFN371" class="et_pb_module et_pb_text et_pb_text_45 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSMDFN371</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a>Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p></div> </div><div id="PSMDFN387" class="et_pb_module et_pb_text et_pb_text_46 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSMDFN387</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a>Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p></div> </div><div id="PSFDFN388" class="et_pb_module et_pb_text et_pb_text_47 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSFDFN388</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a>Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p></div> </div><div id="PSMDFN393" class="et_pb_module et_pb_text et_pb_text_48 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSMDFN393</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a>Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="PSFDFN394" class="et_pb_module et_pb_text et_pb_text_49 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSFDFN394</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener">A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome</a><br />Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em>. 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="PSADFN414" class="et_pb_module et_pb_text et_pb_text_50 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN414</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29581305" target="_blank" rel="noopener noreferrer">Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts</a><br />DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A. 2018 Apr 16;:]. <em>Proc Natl Acad Sci U S A</em>. 2018;115(16):4206‐4211. doi:10.1073/pnas.1802811115</p></div> </div><div id="PSADFN425" class="et_pb_module et_pb_text et_pb_text_51 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>PSADFN425</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29581305" target="_blank" rel="noopener noreferrer">Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts</a><br />DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A. 2018 Apr 16;:].</p></div> </div><div id="HGADFN003 iPS1B" class="et_pb_module et_pb_text et_pb_text_52 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN003 iPS1B</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32032552" target="_blank" rel="noopener noreferrer">iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome</a><br />Atchison L, Abutaleb NO, Snyder-Mounts E, et al. <em>Stem Cell Reports</em> 2020;14(2):325‐337. doi:10.1016/j.stemcr.2020.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/29619860" target="_blank" rel="noopener noreferrer">Progerin Phosphorylation in Interphase Is Lower and Less Mechanosensitive Than lamin-A,C in iPS-derived Mesenchymal Stem Cells</a><br />Cho S, Abbas A, Irianto J, et al.. <em>Nucleus</em> 2018;9(1):230-245. doi:10.1080/19491034.2018.1460185</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a>Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em> 2017;16(4):870‐887. doi:10.1111/acel.12621</p></div> </div><div id="HGADFN003 iPS1C" class="et_pb_module et_pb_text et_pb_text_53 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN003 iPS1C</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38576084/">Progeria-based vascular model identifies networks associated with cardiovascular aging and disease</a><br />Ngubo M, Chen Z, McDonald D, et al. <em>Aging Cell</em>. Published online April 4, 2024. doi:10.1111/acel.14150</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32032552" target="_blank" rel="noopener noreferrer">iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome </a><br />Atchison L, Abutaleb NO, Snyder-Mounts E, et al. <em>Stem Cell Reports</em> 2020;14(2):325‐337. doi:10.1016/j.stemcr.2020.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em>. 2017;16(4):870‐887. doi:10.1111/acel.12621</p></div> </div><div id="HGADFN003 iPS1D" class="et_pb_module et_pb_text et_pb_text_54 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 class="title10" style="text-align: left;" align="center"><strong>HGADFN003 iPS1D</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36977745/" target="_blank" rel="noopener">Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.</a><br />Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038/s41598-023-32035-3. PMID: 36977745; PMCID: PMC10050176.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32032552" target="_blank" rel="noopener noreferrer">iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome</a><br />Atchison L, Abutaleb NO, Snyder-Mounts E, et al. <em>Stem Cell Reports</em> 2020;14(2):325‐337. doi:10.1016/j.stemcr.2020.01.005</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31411525" target="_blank" rel="noopener noreferrer">Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome</a><br />Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. <em>Cell Cycle </em>2019;18(19):2495‐2508. doi:10.1080/15384101.2019.1651587</p></div> </div><div id="HGMDFN090 iPS1B" class="et_pb_module et_pb_text et_pb_text_55 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGMDFN090 iPS1B</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31411525" target="_blank" rel="noopener noreferrer">Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome</a><br />Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. <em>Cell Cycle</em> 2019;18(19):2495‐2508. doi:10.1080/15384101.2019.1651587</p> <p><strong> </strong><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em>. 2017;16(4):870‐887. doi:10.1111/acel.12621</p></div> </div><div id="HGMDFN090 iPS1C" class="et_pb_module et_pb_text et_pb_text_56 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGMDFN090 iPS1C</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38576084/">Progeria-based vascular model identifies networks associated with cardiovascular aging and disease</a><br />Ngubo M, Chen Z, McDonald D, et al. <em>Aging Cell</em>. Published online April 4, 2024. doi:10.1111/acel.14150</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37569335/">Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells</a><br />Daily N, Elson J, Wakatsuki T. <em>Int J Mol Sci</em>. 2023;24(15):11959. Published 2023 Jul 26. doi:10.3390/ijms241511959</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em>. 2017;16(4):870‐887. doi:10.1111/acel.12621</p></div> </div><div id="HGADFN167 iPS1J" class="et_pb_module et_pb_text et_pb_text_57 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN167 iPS1J</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37569335/">Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells</a><br />Daily N, Elson J, Wakatsuki T. <em>Int J Mol Sci</em>. 2023;24(15):11959. Published 2023 Jul 26. doi:10.3390/ijms241511959</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36505085/" target="_blank" rel="noopener">Modelling premature cardiac aging with induced pluripotent stem cells from a Hutchinson-Gilford Progeria Syndrome patient</a><br />Monnerat G, Kasai-Brunswick TH, Asensi KD, et al. Modelling premature cardiac aging with induced pluripotent stem cells from a hutchinson-gilford Progeria Syndrome patient. <em>Front Physiol</em>. 2022;13:1007418. Published 2022 Nov 23. doi:10.3389/fphys.2022.1007418</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em>. 2017;16(4):870‐887. doi:10.1111/acel.12621</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/24843141/" target="_blank" rel="noopener noreferrer">Mechanisms Controlling the Smooth Muscle Cell Death in Progeria via Down-Regulation of poly(ADP-ribose) Polymerase 1</a><br />Zhang H, Xiong ZM, Cao K. <em>Proc Natl Acad Sci U S A.</em> 2014;111(22):E2261‐E2270. doi:10.1073/pnas.1320843111</p></div> </div><div id="HGADFN167 iPS1Q" class="et_pb_module et_pb_text et_pb_text_58 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGADFN167 iPS1Q</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36117952/" target="_blank" rel="noopener">Vascular senescence in progeria: role of endothelial dysfunction</a><br />Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP. Eur Heart J Open. 2022;2(4):oeac047. Published 2022 Jul 28. doi:10.1093/ehjopen/oeac047</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31411525" target="_blank" rel="noopener noreferrer">Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome</a><br />Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. <em>Cell Cycle</em> 2019;18(19):2495‐2508. doi:10.1080/15384101.2019.1651587</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em> 2017;16(4):870‐887. doi:10.1111/acel.12621</p></div> </div><div id="HGFDFN168 iPS1D2" class="et_pb_module et_pb_text et_pb_text_59 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGFDFN168 iPS1D2</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em>. 2017;16(4):870‐887. doi:10.1111/acel.12621</p> <p><strong> </strong><a href="https://pubmed.ncbi.nlm.nih.gov/24843141/" target="_blank" rel="noopener noreferrer">Mechanisms Controlling the Smooth Muscle Cell Death in Progeria via Down-Regulation of poly(ADP-ribose) Polymerase 1</a><br />Zhang H, Xiong ZM, Cao K. <em>Proc Natl Acad Sci U S A</em> 2014;111(22):E2261‐E2270. doi:10.1073/pnas.1320843111</p></div> </div><div id="HGFDFN168 iPS1P" class="et_pb_module et_pb_text et_pb_text_60 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGFDFN168 iPS1P</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36117952/" target="_blank" rel="noopener">Vascular senescence in progeria: role of endothelial dysfunction</a><br />Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP. Eur Heart J Open. 2022;2(4):oeac047. Published 2022 Jul 28. doi:10.1093/ehjopen/oeac047</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31411525" target="_blank" rel="noopener noreferrer">Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome</a><br />Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. <em>Cell Cycle</em> 2019;18(19):2495‐2508. doi:10.1080/15384101.2019.1651587</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/28597562" target="_blank" rel="noopener noreferrer">Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape</a><br />Chen Z, Chang WY, Etheridge A, et al. <em>Aging Cell</em> 2017;16(4):870‐887. doi:10.1111/acel.12621</p></div> </div><div id="HGALBV009" class="et_pb_module et_pb_text et_pb_text_61 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>HGALBV009</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34448355/">Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria</a><br />González-Dominguez A, Montañez R, Castejón-Vega B, et al. [published online ahead of print, 2021 Aug 27]. <em>EMBO Mol Med</em>. 2021;e14012. doi:10.15252/emmm.202114012</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21980471">Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.</a><br />Rodríguez S, Eriksson M. <em>PLoS One.</em> 2011;6(9):e25472. Epub 2011 Sep 29.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGMLBV010" class="et_pb_module et_pb_text et_pb_text_62 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGMLBV010</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGALBV011" class="et_pb_module et_pb_text et_pb_text_63 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGALBV011</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21980471">Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.</a><br />Rodríguez S, Eriksson M. <em>PL</em><em>oS One.</em> 2011;6(9):e25472. Epub 2011 Sep 29.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGMLBV013" class="et_pb_module et_pb_text et_pb_text_64 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGMLBV013</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGFLBV021" class="et_pb_module et_pb_text et_pb_text_65 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGFLBV021</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34448355/">Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria</a><br />González-Dominguez A, Montañez R, Castejón-Vega B, et al. [published online ahead of print, 2021 Aug 27]. <em>EMBO Mol Med</em>. 2021;e14012. doi:10.15252/emmm.202114012</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGMLBV023" class="et_pb_module et_pb_text et_pb_text_66 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGMLBV023</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGFLBV031" class="et_pb_module et_pb_text et_pb_text_67 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGFLBV031</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGFLBV050" class="et_pb_module et_pb_text et_pb_text_68 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGFLBV050</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGALBV057" class="et_pb_module et_pb_text et_pb_text_69 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGALBV057</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGMLBV058" class="et_pb_module et_pb_text et_pb_text_70 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGMLBV058</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGMLBV058" class="et_pb_module et_pb_text et_pb_text_71 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;"><strong>HGSLBV059</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<strong> </strong></p></div> </div><div id="HGMLBV066" class="et_pb_module et_pb_text et_pb_text_72 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGMLBV066</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGFLBV067" class="et_pb_module et_pb_text et_pb_text_73 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGFLBV067</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21902803">Stem cell depletion in Hutchinson-Gilford progeria syndrome.</a><br />Rosengardten Y, McKenna T, Grochová D, Eriksson M. <em>Aging Cell.</em> 2011 Dec;10(6):1011-20. doi: 10.1111/j.1474-9726.2011.00743.x. Epub 2011 Oct 11.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGALBV071" class="et_pb_module et_pb_text et_pb_text_74 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGALBV071</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGMLBV081" class="et_pb_module et_pb_text et_pb_text_75 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGMLBV081</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="HGFLBV082" class="et_pb_module et_pb_text et_pb_text_76 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4 style="text-align: left;" align="center"><strong>HGFLBV082</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/12714972">Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.</a><br />Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. <em>Nature</em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.</p></div> </div><div id="DNA" class="et_pb_module et_pb_text et_pb_text_77 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>DNA</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/35752705/" target="_blank" rel="noopener">Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome</a><br />Díez-Díez M, Amorós-Pérez M, de la Barrera J, et al. [published online ahead of print, 2022 Jun 25]. Geroscience. 2022;10.1007/s11357-022-00607-2. doi:10.1007/s11357-022-00607-2</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/27920058/" target="_blank" rel="noopener noreferrer">A Novel Somatic Mutation Achieves Partial Rescue in a Child With Hutchinson-Gilford Progeria Syndrome</a><br />Bar DZ, Arlt MF, Brazier JF, et al. <em>J Med Genet</em> 2017;54(3):212-216. doi:10.1136/jmedgenet-2016-104295</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31152494/" target="_blank" rel="noopener noreferrer">Transient introduction of human telomerase mRNA improves hallmarks of progeria cells</a><br />Li Y, Zhou G, Bruno IG, et al. <em>Aging Cell</em> 2019;18(4):e12979. doi:10.1111/acel.12979</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/30048243/" target="_blank" rel="noopener noreferrer">Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies</a><br />Horvath S, Oshima J, Martin GM, et al. <em>Aging</em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632/aging.101508</p></div> </div><div id="Autopsy tissue" class="et_pb_module et_pb_text et_pb_text_78 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>Autopsy tissue</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38141925/">Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging</a><br />Santinha D, Vilaça A, Estronca L, et al. <em>Mol Cell Proteomics</em>. 2024;23(1):100706. doi:10.1016/j.mcpro.2023.100706</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/25667091/" target="_blank" rel="noopener noreferrer">Atherosclerosis in ancient humans, accelerated aging syndromes and normal aging: is lamin a protein a common link?</a><br />Miyamoto MI, Djabali K, Gordon LB. <em>Glob Heart</em>. 2014;9(2):211-218. doi:10.1016/j.gheart.2014.04.001</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/20798379/" target="_blank" rel="noopener noreferrer">Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging</a><br />Olive M, Harten I, Mitchell R, et al. <em>Arterioscler Thromb Vasc Biol</em> 2010;30(11):2301-2309. doi:10.1161/ATVBAHA.110.209460</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/16461887/" target="_blank" rel="noopener noreferrer">Hutchinson-Gilford Progeria Mutant Lamin A Primarily Targets Human Vascular Cells as Detected by an anti-Lamin A G608G Antibody</a><br />McClintock D, Gordon LB, Djabali K. <em>Proc Natl Acad Sci U S A.</em> 2006;103(7):2154-2159. doi:10.1073/pnas.0511133103</p></div> </div><div id="Plasma" class="et_pb_module et_pb_text et_pb_text_79 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>Plasma</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/38578073/">Aged-vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt-axis</a><br />Fleischhacker V, Milosic F, Bricelj M, et al. <em>Aging Cell</em>. Published online April 5, 2024. doi:10.1111/acel.14139</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/31254107/" target="_blank" rel="noopener noreferrer">Metabolomic Profiling Suggests Systemic Signatures of Premature Aging Induced by Hutchinson-Gilford Progeria Syndrome</a><br />Monnerat G, Evaristo GPC, Evaristo JAM, et al. <em>Metabolomics</em> 2019;15(7):100. Published 2019 Jun 28. doi:10.1007/s11306-019-1558-6</p> <p style="font-weight: 400;"><a href="https://pubmed.ncbi.nlm.nih.gov/36919608/">Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation</a><br />Gordon LB, Norris W, Hamren S, et al. <em>Circulation</em>. 2023;147(23):1734-1744. doi:10.1161/CIRCULATIONAHA.122.060002</p></div> </div><div id="Serum" class="et_pb_module et_pb_text et_pb_text_80 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>Serum</strong></h4> <p><a href="https://pubmed.ncbi.nlm.nih.gov/32896271/" target="_blank" rel="noopener noreferrer">Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome</a><br />Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. <em>Elife</em>. 2020 Sep 8;9:e54383. doi: 10.7554/eLife.54383. PMID: 32896271; PMCID: PMC7478891.</p></div> </div><div id="buffycoats" class="et_pb_module et_pb_text et_pb_text_81 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h4><strong>Buffy Coats</strong></h4> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569443/" target="_blank" rel="noopener">Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry</a><br />Camafeita E, Jorge I, Rivera-Torres J, Andrés V, Vázquez J. <em>Int J Mol Sci</em>. 2022;23(19):11733. 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