A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="6C6DzAoKocCL7BRxSzVXcL9fy2CGWRsOi9XQ3u51Cy5mjxTf13cndfd8HecjccRw"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="6C6DzAoKocCL7BRxSzVXcL9fy2CGWRsOi9XQ3u51Cy5mjxTf13cndfd8HecjccRw"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="6C6DzAoKocCL7BRxSzVXcL9fy2CGWRsOi9XQ3u51Cy5mjxTf13cndfd8HecjccRw"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="6C6DzAoKocCL7BRxSzVXcL9fy2CGWRsOi9XQ3u51Cy5mjxTf13cndfd8HecjccRw"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="19549889"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Cancer research" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Cancer research" data-pinger-ignore> Cancer Res </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Cancer research"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Cancer Res" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Cancer Res"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Res%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Cancer Res"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Cancer Res"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Cancer Res"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2009 Jul 1;69(13):5296-300.</span> </div> <span class="citation-doi"> doi: 10.1158/0008-5472.CAN-09-0814. </span> <span class="secondary-date"> Epub 2009 Jun 23. </span> </div> <h1 class="heading-title"> A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Sorensen+AG&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="A Gregory Sorensen">A Gregory Sorensen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA. sorensen@nmr.mgh.harvard.edu" href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Batchelor+TT&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tracy T Batchelor">Tracy T Batchelor</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+WT&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wei-Ting Zhang">Wei-Ting Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chen+PJ&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Poe-Jou Chen">Poe-Jou Chen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yeo+P&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Priscilla Yeo">Priscilla Yeo</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+M&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Meiyun Wang">Meiyun Wang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jennings+D&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dominique Jennings">Dominique Jennings</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wen+PY&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patrick Y Wen">Patrick Y Wen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lahdenranta+J&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Johanna Lahdenranta">Johanna Lahdenranta</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ancukiewicz+M&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Marek Ancukiewicz">Marek Ancukiewicz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=di+Tomaso+E&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Emmanuelle di Tomaso">Emmanuelle di Tomaso</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Duda+DG&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dan G Duda">Dan G Duda</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jain+RK&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rakesh K Jain">Rakesh K Jain</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/19549889/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA. sorensen@nmr.mgh.harvard.edu</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">19549889</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC2824172&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2824172/" data-ga-category="full_text" data-ga-action="PMCID" > PMC2824172 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1158/0008-5472.CAN-09-0814&id_type=DOI" href="https://doi.org/10.1158/0008-5472.can-09-0814" data-ga-category="full_text" data-ga-action="DOI" > 10.1158/0008-5472.CAN-09-0814 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">A Gregory Sorensen</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Cancer Res<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2009">2009</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" 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id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Cancer research" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Cancer research" data-pinger-ignore> Cancer Res </button><div id="short-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Cancer research"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Cancer Res" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Cancer Res"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Res%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Cancer Res"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Cancer Res"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Cancer Res"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2009 Jul 1;69(13):5296-300.</span> </div> <span class="citation-doi"> doi: 10.1158/0008-5472.CAN-09-0814. </span> <span class="secondary-date"> Epub 2009 Jun 23. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Sorensen+AG&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="A Gregory Sorensen">A Gregory Sorensen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA. sorensen@nmr.mgh.harvard.edu" href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Batchelor+TT&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tracy T Batchelor">Tracy T Batchelor</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+WT&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wei-Ting Zhang">Wei-Ting Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chen+PJ&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Poe-Jou Chen">Poe-Jou Chen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yeo+P&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Priscilla Yeo">Priscilla Yeo</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+M&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Meiyun Wang">Meiyun Wang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jennings+D&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dominique Jennings">Dominique Jennings</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wen+PY&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patrick Y Wen">Patrick Y Wen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lahdenranta+J&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Johanna Lahdenranta">Johanna Lahdenranta</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ancukiewicz+M&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Marek Ancukiewicz">Marek Ancukiewicz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=di+Tomaso+E&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Emmanuelle di Tomaso">Emmanuelle di Tomaso</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Duda+DG&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dan G Duda">Dan G Duda</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jain+RK&cauthor_id=19549889" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rakesh K Jain">Rakesh K Jain</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02114, USA. sorensen@nmr.mgh.harvard.edu</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">19549889</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC2824172&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2824172/" data-ga-category="full_text" data-ga-action="PMCID" > PMC2824172 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1158/0008-5472.CAN-09-0814&id_type=DOI" href="https://doi.org/10.1158/0008-5472.can-09-0814" data-ga-category="full_text" data-ga-action="DOI" > 10.1158/0008-5472.CAN-09-0814 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/19549889/citations/" data-citation-style="nlm" data-pubmed-format-link="/19549889/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Early imaging or blood biomarkers of tumor response are desperately needed to customize antiangiogenic therapy for cancer patients. Anti-vascular endothelial growth factor (VEGF) therapy can "normalize" brain tumor vasculature by decreasing vessel diameter and permeability, and thinning the abnormally thick basement membrane. We hypothesized that the extent of vascular normalization will be predictive of outcome of anti-VEGF therapy in glioblastoma. We used advanced magnetic resonance imaging methods to monitor vascular parameters and treatment response in 31 recurrent glioblastoma patients enrolled in a phase II trial of cediranib, an oral pan-VEGF receptor tyrosine kinase inhibitor. We evaluated the correlation between clinical outcome and magnetic resonance imaging-measured changes in vascular permeability/flow (i.e., K(trans)) and in microvessel volume, and the change of circulating collagen IV levels, all after a single dose of cediranib. Here, we show that evaluation of biomarkers as early as after one day of anti-VEGF therapy with cediranib is predictive of response in patients with recurrent glioblastoma. Changes in K(trans), microvessel volume, and circulating collagen IV correlated with duration of overall survival and/or progression-free survival (P < 0.05). When we combined these three parameters into a "vascular normalization index," we found that it closely associated with overall survival (rho = 0.54; P = 0.004) and progression-free survival (rho = 0.6; P = 0.001). The vascular normalization index described here should be validated in randomized clinical trials. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one"><bold>Disclosure of Potential Conflicts of Interest</bold></p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">A.G. Sorensen: Commercial research grants, AstraZeneca, Exelixis, Genentech, Novartis, Schering-Plough, Siemens, and Takeda-Millennium; consultant/advisory board, EPIX Pharmaceuticals, AstraZeneca, Genentech, Takeda-Millennium, Bayer/Schering, Olea Medical, Mitsubishi, Novartis, and Siemens. T.T. Batchelor: Honoraria from speakers bureau, Vertex, Schering-Plough, and Enzon; consultant/advisory board, AstraZeneca, Genentech, and Takeda-Millennium. R.K. Jain: Commercial research grant, AstraZeneca and Dyax; consultant/advisory board, AstraZeneca, Dyax, Millennium, and SynDevRx. The other authors disclosed no potential conflicts of interest.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/afe6570ab0c9/nihms175391f1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="602" data-image-height="446" data-image-alt="Figure 1" data-pmc-id="PMC2824172" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/a92aa89ea864/nihms175391f1.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="602"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="446"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Best responses after cediranib monotherapy… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Best responses after cediranib monotherapy in recurrent glioblastoma. Initial ( <i> left </i> ) and… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1 </strong> <div class="figure-caption-contents">Best responses after cediranib monotherapy in recurrent glioblastoma. Initial (<i>left</i>) and best-response (<i>right</i>; in each pair) postgadolinium axial T1-weighted MRI scans from 30 patients. <i>Red outlines,</i> the tumor borders as determined by expert neuroradiologists blinded to patient identity and scan date.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/8a3c4f900c51/nihms175391f2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="601" data-image-height="384" data-image-alt="Figure 2" data-pmc-id="PMC2824172" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/da1a92571978/nihms175391f2.gif" alt="Figure 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="601"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="384"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Association between changes in K… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Association between changes in K <sup> trans </sup> , CBV, and collagen IV and survival… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2 </strong> <div class="figure-caption-contents">Association between changes in K<sup>trans</sup>, CBV, and collagen IV and survival outcomes. <i>A,</i> correlations with PFS at 6 mo. <i>B,</i> correlations with OS at 1 y. <i>C</i> and <i>D,</i> scatter plots: VNI versus time-to-progression (<i>C</i>) and time-to-death (<i>D</i>).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/167398b81a7d/nihms175391f3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="602" data-image-height="668" data-image-alt="Figure 3" data-pmc-id="PMC2824172" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/b8a28de62c2e/nihms175391f3.gif" alt="Figure 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="602"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="668"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Multivariate analyses for correlation between… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Multivariate analyses for correlation between parameters related to vascular normalization and survival outcomes.… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3 </strong> <div class="figure-caption-contents">Multivariate analyses for correlation between parameters related to vascular normalization and survival outcomes. <i>A,</i> the ratio of K<sup>trans</sup> and of collagen IV measured at day 1 and baseline and VNI values are significantly correlated with PFS at 3, 4.5, and 6 mo. <i>B,</i> the ratio of K<sup>trans</sup> and of microvessel CBV measured at day 1 and baseline and VNI values are significantly correlated with OS at 6, 9, and 12 mo. Strikingly, all 17 patients with K<sup>trans</sup> values at day 1 higher than 25% of baseline value died within 1 y, whereas 5 (42%) of the 12 patients with a K<sup>trans</sup> drop below 25% of baseline value survived >1 y.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="figure-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/2f83f15626f6/nihms175391f4.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="800" data-image-height="654" data-image-alt="Figure 4" data-pmc-id="PMC2824172" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42a/2824172/86ee636d1864/nihms175391f4.gif" alt="Figure 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="800"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="654"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 4 </p> </strong> <div class="figure-caption-contents"><p> Potential predictive value of immediate… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 4 </p> </strong> <div class="figure-caption-contents"><p> Potential predictive value of immediate changes in parameters related to vascular normalization after… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 4 </strong> <div class="figure-caption-contents">Potential predictive value of immediate changes in parameters related to vascular normalization after cediranib. <i>A</i> and <i>B,</i> representative patient examples: a patient with a high VNI and 566-d survival (<i>A</i>), versus a patient with a low VNI and 58-d survival (<i>B</i>); note especially the dramatic change in K<sup>trans</sup>, which decreased in both patients, albeit to differing degrees. <i>Pre-Tx,</i> pretreatment; <i>post-Tx,</i> postreatment. <i>C</i> and <i>D,</i> Kaplan-Meier PFS (<i>C</i>) and OS (<i>D</i>) distributions for index quartiles.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/20458050/" ref="article_id=20458050&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="20458050" data-ga-label=""> Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK.</span> <span class="docsum-authors short-authors">Batchelor TT, et al.</span> <span class="docsum-journal-citation full-journal-citation">J Clin Oncol. 2010 Jun 10;28(17):2817-23. doi: 10.1200/JCO.2009.26.3988. 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short-authors">Al-Gizawiy MM, et al.</span> <span class="docsum-journal-citation full-journal-citation">Front Oncol. 2024 Jan 15;13:1278157. doi: 10.3389/fonc.2023.1278157. eCollection 2023.</span> <span class="docsum-journal-citation short-journal-citation">Front Oncol. 2024.</span> <span class="citation-part">PMID: <span class="docsum-pmid">38288102</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> </ul> <div class="actions-bar"> <a class="show-all-linked-articles" data-href="/?linkname=pubmed_pubmed_citedin&from_uid=19549889" data-ga-category="cited_by" data-ga-action="show_all" > See all "Cited by" articles </a> </div> </div> <div class="references" id="references"> <h2 class="title"> References </h2> <div id='top-references-list' class="references-lists-container"> <div class="refs-list"> <ol id="top-references-list-1" class="references-list"> <li> <ol class="references-and-notes-list"> <li 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Cancer Cell. 2007;11:83–95. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2748664/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC2748664" > PMC </a> - <a class="reference-link" href="/17222792/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="17222792" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/19549889/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 20 references </button> </div> </div> </div> </div> <div id="publication-types" class="publication-types keywords-section"> <h2 class="title"> Publication types </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Research 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Blood Volume" tabindex="0" aria-controls="keyword-actions-mesh-terms-2" aria-expanded="false" data-pinger-ignore> Blood Volume </button><div id="keyword-actions-mesh-terms-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Blood Volume"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Blood+Volume%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Blood+Volume%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Blood Volume"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Blood Volume"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Blood+Volume" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Blood Volume"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Blood Volume"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Blood Volume"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Brain Neoplasms / blood" tabindex="0" aria-controls="keyword-actions-mesh-terms-3" aria-expanded="false" data-pinger-ignore> Brain Neoplasms / blood </button><div id="keyword-actions-mesh-terms-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Brain Neoplasms / blood"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" 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keyword-link" aria-label="Toggle dropdown menu for keyword Collagen / blood" tabindex="0" aria-controls="keyword-actions-mesh-terms-7" aria-expanded="false" data-pinger-ignore> Collagen / blood </button><div id="keyword-actions-mesh-terms-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Collagen / blood"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Collagen%2Fblood%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Collagen%2Fblood%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Collagen/blood"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Collagen / blood"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Collagen" 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Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Glioblastoma / blood" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Glioblastoma / blood </button><div id="keyword-actions-mesh-terms-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Glioblastoma / blood"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Glioblastoma%2Fblood%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Glioblastoma%2Fblood%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Glioblastoma/blood"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Glioblastoma / blood"> Search in 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class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Glioblastoma / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Glioblastoma%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Glioblastoma%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Glioblastoma/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Glioblastoma / drug therapy*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Glioblastoma" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Glioblastoma / drug therapy*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Glioblastoma/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Glioblastoma/drug therapy"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Glioblastoma / mortality" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Glioblastoma / mortality </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Glioblastoma / mortality"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Glioblastoma%2Fmortality%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Glioblastoma%2Fmortality%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Glioblastoma/mortality"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Glioblastoma / mortality"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Glioblastoma" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Glioblastoma / mortality"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Glioblastoma/mortality"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Glioblastoma/mortality"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Glioblastoma / pathology" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Glioblastoma / pathology </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Glioblastoma / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Glioblastoma%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Glioblastoma%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Glioblastoma/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Glioblastoma / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" 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</a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Hematologic Tests/statistics and numerical data"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Hematologic Tests/statistics and numerical data"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-14" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Magnetic Resonance Imaging / methods" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Magnetic Resonance Imaging / methods </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Magnetic Resonance Imaging / methods"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Magnetic+Resonance+Imaging%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Magnetic+Resonance+Imaging%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Magnetic Resonance Imaging/methods"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Magnetic Resonance Imaging / methods"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Magnetic+Resonance+Imaging" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Magnetic Resonance Imaging / methods"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Magnetic Resonance Imaging/methods"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Magnetic Resonance Imaging/methods"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Neoplasm Recurrence, Local / blood" tabindex="0" aria-controls="keyword-actions-mesh-terms-16" aria-expanded="false" data-pinger-ignore> Neoplasm Recurrence, Local / blood </button><div id="keyword-actions-mesh-terms-16" class="keyword-actions-dropdown 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class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Neoplasm Recurrence, Local/blood"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Neoplasm Recurrence, Local/blood"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Neoplasm Recurrence, Local / drug therapy*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-17" aria-expanded="false" data-pinger-ignore> Neoplasm Recurrence, Local / drug therapy* </button><div id="keyword-actions-mesh-terms-major-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Neoplasm Recurrence, Local / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neoplasm+Recurrence%2C+Local%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Neoplasm+Recurrence%2C+Local%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neoplasm Recurrence, Local/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neoplasm Recurrence, Local / drug therapy*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neoplasm+Recurrence%2C+Local" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Neoplasm Recurrence, Local / drug therapy*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Neoplasm Recurrence, Local/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Neoplasm Recurrence, Local/drug therapy"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Neoplasm Recurrence, Local / mortality" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Neoplasm Recurrence, Local / mortality </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Neoplasm Recurrence, Local / mortality"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neoplasm+Recurrence%2C+Local%2Fmortality%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Neoplasm+Recurrence%2C+Local%2Fmortality%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neoplasm Recurrence, Local/mortality"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neoplasm Recurrence, Local / mortality"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neoplasm+Recurrence%2C+Local" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Neoplasm Recurrence, Local / mortality"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Neoplasm Recurrence, Local/mortality"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Neoplasm Recurrence, Local/mortality"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Neoplasm Recurrence, Local / pathology" tabindex="0" aria-controls="keyword-actions-mesh-terms-19" aria-expanded="false" data-pinger-ignore> Neoplasm Recurrence, Local / pathology </button><div id="keyword-actions-mesh-terms-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Neoplasm Recurrence, Local / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neoplasm+Recurrence%2C+Local%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Neoplasm+Recurrence%2C+Local%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neoplasm Recurrence, Local/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neoplasm Recurrence, Local / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neoplasm+Recurrence%2C+Local" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Neoplasm Recurrence, Local / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Neoplasm Recurrence, Local/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Neoplasm Recurrence, Local/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Predictive Value of Tests" tabindex="0" aria-controls="keyword-actions-mesh-terms-20" aria-expanded="false" data-pinger-ignore> Predictive Value of Tests </button><div id="keyword-actions-mesh-terms-20" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Predictive Value of Tests"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Predictive+Value+of+Tests%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Predictive+Value+of+Tests%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Predictive Value of Tests"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Predictive Value of Tests"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Predictive+Value+of+Tests" data-ga-category="search_mesh" data-ga-action="mesh_term_link" 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class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Quinazolines%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Quinazolines%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Quinazolines/therapeutic use"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Quinazolines / therapeutic use*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Quinazolines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Quinazolines / therapeutic use*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Quinazolines/therapeutic use"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Quinazolines/therapeutic use"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Survival Rate" tabindex="0" aria-controls="keyword-actions-mesh-terms-22" aria-expanded="false" data-pinger-ignore> Survival Rate </button><div id="keyword-actions-mesh-terms-22" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Survival Rate"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Survival+Rate%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Survival+Rate%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Survival Rate"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Survival Rate"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Survival+Rate" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Survival Rate"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Survival Rate"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Survival Rate"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antineoplastic Agents" tabindex="0" aria-controls="keyword-actions-substances-0" 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A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients - PubMed