CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "onlinelibrary.wiley.com",cType: 'managed',cRay: '9271743e1e9b6027',cH: 'c3SLdUQN5Pvozl8GG2W5GQEtCTQjCRM2tDi0CvEADKM-1743105417-1.2.1.1-zUmTmn4iu29BZekiTr0k9nMY362JrJz.rVHtQ3E8gbPxK8MTmKy5zzUf5xLi38O0',cUPMDTk: "\/doi\/10.1002\/neu.20241?__cf_chl_tk=F_s4ZeiggFhJ8C6Jjf2zQOWkxA8SGNscLa6OT2pohog-1743105417-1.0.1.1-JybUTowz0cNZ_pVj.b8SD8UKc1gtzzI0T9gRGGlzHmA",cFPWv: 'b',cITimeS: '1743105417',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1002\/neu.20241?__cf_chl_f_tk=F_s4ZeiggFhJ8C6Jjf2zQOWkxA8SGNscLa6OT2pohog-1743105417-1.0.1.1-JybUTowz0cNZ_pVj.b8SD8UKc1gtzzI0T9gRGGlzHmA",md: "SmtwLPLItf2mW89xJahda3i6W.K4zGOj2luaPzHR24Y-1743105417-1.2.1.1-QpvXvVH42oZqvyZJoj_CUwym7jSbT.lg4bcVsjpB2eWXfkMfAjIYHWWUBohb250xu6_9qVhxWld74odRHRAeiJ43hhmUde7IViZ0ZU9WA.z2KwFrBo39uV6mZldV9NOJWBnZIwBflXvbce1bJEhwKz9ZOLjgsfFx7e3425O.DMW5f7Z8is2LmtR_vtCDFwa2BMSQvaSD81SdfarAyULI4gPJYPb1e7VzPC9nodfZpc2S8GVoBn3Qh50EOWkMgO5PqQOJNuc1n7TLfmK9bi.9oXFKWgzc0ggpHBLJ82NnqftJRveR2zIPwNDE1gSVSeujQqXIWkCDkyPhOzh8rwKe.g5ppSJo_tIAQRMuEHGcHJcWZx15uaHLKvn8kydZ5.9EznytIumThuCaoKa2bclJjqrRJJL1mT2f6CRaQ8oVPfW78Ml2LuGdCLB0ZSA0mgzTmlnv02_NA64jPdR2oovweahISD6E2OBNsUx4myFlmec_hYxXHMCEwjkXcFZH9dyHnxeYne4Gv84F3dJCsLj0RZ1HXsDefDU9TobjkheOr_fGK5y.pPCjVGHni42gcDMMo_T_ChBMJNAHqBF3_xmY8K7nfWEZDdREpwpH9JA7ET1ZcPROkKPCAZmt.maUnBCM9BWzgcXDJNMjRuk1Peaj3bke3h9ukWu.ZQMA3dxfuRv5AvgAIpGKua6qx8fVrlfZUPt67Szn.2SfmvPLUM15zNUzNAShe7TBltO..qo9mfCdp2uRKkS42hCK8YHa0ShrNTpgaTJqSmwZXGacKTgNkF8pGnLaJ6haffpd_pLFnbI4gzjgHpeO5b7igk98mnoqb9GYrMXichN2W.SzrIftjofw6Ptvz_OpgUaSXf3Vj0XxOmWEsh7WzmaLQT49E1GgB5.4Y4xwJaMouCkgY5TsMFjEkE2GqbxJzRf8XtYOZ.ai4BS7p63jSsHBE_SDP7YNyWPXooy77mtsqcEgOwxt5OrLDLbfemfHiiRtN5p4XzBlEj_86Vt3U.ADGSI7VhoubkUvHFACaHcnT98h8vu0Hcex02Kjk1ZhCyP9nCDGmkWNdY5uRfSlKSOikaSvSxb_vc4dY_wFOCMTjl0h9ZfsRK0esSsHI6uyz7LLctu6XzRV5VT1rGNCNG8IH03LqQETnPyYacKj_QcMrfhERmsmaZ.ldRXdNYVr7IDJCkZc2ucsTPXVr_OC4o3mhOyLkFtuQR63sOCTZmX0FJVXA33xfDAG6Z44yo4r4K9EQuMVODT5kC7j5RA4UZ_mRgOFq6RlwKSG_Y2Ggfjfb7bj2.6jEw",mdrd: "opUbTHIBb2hMp9aEyCAaSnJFAItR_8LZNaJzR4BRZMk-1743105417-1.2.1.1-IgTtgwm4nEqW6z1DHBjIfMw2WUt573rSp_src8ol28qnNqJTdK.C5LCvzuxEH2kuGjAnO8mEEeT.ftR5v.1g_igYaQuW.1QJ9oGg_qnjS.6l8yWt1bf_WgerH6.bQIymiQQ5iIbTGEKBSmLGk.YN1P5bsYQYACc0UrOMVtclgsPqbLxtox23d9gGtQtogW1Ubp72_Mex40wnzyoRzqPr4VnANkLXnAmLd7siiQ5hkTXVnSbdMWgjpwa.w0pResbrHTIzXJIfjMSvZFHKzwuvwbecy81Tm3qYOwWPZMhhd.tY2kWU9iQxk5QI6qyRuOgwi_VgC1wBMoSxDMfjOz5bJeEiRwNlrnyrGF9lGRFRsXezkqPC6k5xT6vfK2ggFo_vQWI3w50m6LKvxinCLOuo6IHZjB8zD.y8PYPX.VELDbNE3qmeNzbSDp76XF.sYVh4hI0oSFJWGCUJpx65ndWGgdX5W_tBKD9hS6m7dWnkEo4g0VN85xYH4NLDgcCCNX7tuNGcc32uU0Z2PlTrwM_5gD3bGsnTj_Jkg4kp38T.KV4jIHePb0O7dH4bmGFCzYYKI6pI33OwcEJwtbLO7lPtRUztByfPS5hG9QGFaqHilC1OcODTtKGltblfiLojC26yyG.iAam838R4RUvQkj5GLcrYgxJBTlvEjwKN4JTVF__WxXpAh14ssKumyLcOHHuBsJCyBVoB_6XOcE87UJL7YHXNVG707wGcDIlCgWWgHY_LAI2zmZclnpc7FqAzEeMrdlr7EzDCHoMPuwA4WudDi_jjbCmrnl3KwNtqomgtiT.txXimUMDDLHYt3Qdnka3wPEvUY7lJtrUo6IKn9vyScCG69P1Rz0PDZ4qlSKGUKIdbGePaNUZKnklEzgQ0MRCc9RO79w20OuxJNbwy5bxU0jOKxu0tQ2bH7pbJg9zNYu5x95m4AV00FzLhr7tr8AkBtcIYMkiSbgsTmhvG2PCBrbULVFIDjUH4pmOc_aoWNZtV.otZPtHGh9RT.lSLsvVyIgmXVHmiZr8SwagHgZHw3tntOSWHr.QLAwAq2YprsW8w_c.enRRaVCSfObekNS.AyiY5wProoj9sIEUFar2OD5H_JbiHHVVpscf45.OMpHfrZEvLUrymnTR4dkUqj9dxZzjQyCJiiDsGNfyxhvNeLe7ND9QlhOXB8cFcqP_XzpHhZx2zHU4q21bf6r8WkmQVIVDdbWKqS_jPoBew6RxAvwtbUGs1p.tTpqo8epxILkKcQnX1wv.JSUuDoeuKsHtbqxTXUspKpD_gsCdCU2y.nk8mii6O2ub0i9vrif0EoVPkmJN6RxcrXC_4ClexqgH8qAy.Hk7Px8cKOSojFLqrY6qDxC_UMjW2mK4R.zfm3shqnN4kNZdz_YuHaVlL5UKhu.xzSYS12As0u5R8x8g2Tq3QuWD98BEnxeBVFNMNiSfmv_SOppC80VjoSfjMGkDyzG6SDSIGuLAFBdWiVZI2ayGfeMmzg9Oip348N41S1.vM6fT6RZBuMx3HJMLv0MpkPr7CY2Sbq3Hp5mQ3TW_hZQO9cVCoe7L_PYiKdJLoWeu7PfUtQ0iMDKuf57wZKkwMOFOB0zJXoWcmC8vafdb.TOWTXqoa8WiFoHzM5OkjaxL1K81vWf9gHi6Tv_fz2j_1qIxK7lSohcakU9lx9grYXClzFJbJ4glGRqdgiVJZ.uox.wasV7VCjl51ApmImEc0Vhet_dQZynWbnJCMRq1_CAzv381UeZpH7Hjo8E.ICNo3.JI__PyQuWic6Lo9cl.rBh0Do_6aB2c5DrZ3UYbRHirFLBc1LRgnmWVrTl3RZNp2VfGi2_F7EkUHDgqgg4VP7t0J9I9aRx4n92ySB54V4Aw1WgsZDrKATy2dHfpOFLsVfm9XCS5bQ9HGl4rID45qwPPQ1uePzS4NAwTw_JamPzDnMEKLrP4Wp3qnV_RVaRMQdpFTfJwHOQro01Scwwy1EDd2FJmZlXKQrljRBOkn8ORV.hnq5rz2NHVOu215rIx53VfIIv1CX3Lz3n_EcOpz9FnKLGGlYbHjuDieOyQwr5L7AIxz5d3YO6NICrjEQwc"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9271743e1e9b6027';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1002\/neu.20241?__cf_chl_rt_tk=F_s4ZeiggFhJ8C6Jjf2zQOWkxA8SGNscLa6OT2pohog-1743105417-1.0.1.1-JybUTowz0cNZ_pVj.b8SD8UKc1gtzzI0T9gRGGlzHmA" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>