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EHD1 (human)
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float:left; width:1000px" class="bold01"> EH domain-containing protein 1 </div> <param id="PTMsites" name="PTMsites" value="[{"ID":"K7","REF":1,"LTP":0,"HTP":1,"POS":7,"NMER":"_MFSWVS<font color=#993333>k</font>DARRKkE","PUBMED":1147572453,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"K13","REF":1,"LTP":0,"HTP":1,"POS":13,"NMER":"SkDARRK<font color=#993333>k</font>EPELFQT","PUBMED":1929024653,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"Y29","REF":1,"LTP":0,"HTP":1,"POS":29,"NMER":"AEGLRQL<font color=#993333>y</font>AQkLLPL","PUBMED":76395,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"K32","REF":3,"LTP":0,"HTP":3,"POS":32,"NMER":"LRQLyAQ<font color=#993333>k</font>LLPLEEH","PUBMED":44487593,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"Y40","REF":1,"LTP":0,"HTP":1,"POS":40,"NMER":"LLPLEEH<font 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color=#993333>k</font>PKLLDTV","PUBMED":1929024665,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"K377","REF":1,"LTP":0,"HTP":1,"POS":377,"NMER":"kFQALkP<font color=#993333>k</font>LLDTVDD","PUBMED":66702375,"MODIFICATION":"ACETYLATION","MODCOLOR":"ACETYLATION","allNum":0},{"ID":"T417","REF":1,"LTP":0,"HTP":1,"POS":417,"NMER":"KGGAFDG<font color=#993333>t</font>MNGPFGH","PUBMED":46204051,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"Y426","REF":3,"LTP":0,"HTP":3,"POS":426,"NMER":"NGPFGHG<font color=#993333>y</font>GEGAGEG","PUBMED":68854001,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"T447","REF":1,"LTP":0,"HTP":1,"POS":447,"NMER":"VVGKDKP<font color=#993333>t</font>yDEIFyt","PUBMED":30458893,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"Y448","REF":3,"LTP":0,"HTP":3,"POS":448,"NMER":"VGKDKPt<font color=#993333>y</font>DEIFytL","PUBMED":76399,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"Y453","REF":88,"LTP":0,"HTP":88,"POS":453,"NMER":"PtyDEIF<font color=#993333>y</font>tLsPVNG","PUBMED":23205,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"T454","REF":7,"LTP":0,"HTP":7,"POS":454,"NMER":"tyDEIFy<font color=#993333>t</font>LsPVNGK","PUBMED":8540787,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"S456","REF":45,"LTP":0,"HTP":45,"POS":456,"NMER":"DEIFytL<font color=#993333>s</font>PVNGKIT","PUBMED":6424921,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"K475","REF":14,"LTP":0,"HTP":14,"POS":475,"NMER":"KKEMVKS<font color=#993333>k</font>LPNtVLG","PUBMED":24613447,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"T479","REF":4,"LTP":0,"HTP":4,"POS":479,"NMER":"VKSkLPN<font color=#993333>t</font>VLGKIWK","PUBMED":63749137,"MODIFICATION":"PHOSPHORYLATION","MODCOLOR":"PHOSPHORYLATION","allNum":0},{"ID":"K483","REF":1,"LTP":0,"HTP":1,"POS":483,"NMER":"LPNtVLG<font color=#993333>k</font>IWKLADV","PUBMED":72624375,"MODIFICATION":"ACETYLATION","MODCOLOR":"ACETYLATION","allNum":0},{"ID":"K486","REF":1,"LTP":0,"HTP":1,"POS":486,"NMER":"tVLGKIW<font color=#993333>k</font>LADVDkD","PUBMED":72629527,"MODIFICATION":"ACETYLATION","MODCOLOR":"ACETYLATION","allNum":0},{"ID":"K492","REF":1,"LTP":0,"HTP":1,"POS":492,"NMER":"WKLADVD<font color=#993333>k</font>DGLLDDE","PUBMED":72602439,"MODIFICATION":"ACETYLATION","MODCOLOR":"ACETYLATION","allNum":0},{"ID":"K492","REF":1,"LTP":0,"HTP":1,"POS":492,"NMER":"WKLADVD<font color=#993333>k</font>DGLLDDE","PUBMED":1929024669,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"K509","REF":2,"LTP":0,"HTP":2,"POS":509,"NMER":"ALANHLI<font color=#993333>k</font>VKLEGHE","PUBMED":54375699,"MODIFICATION":"UBIQUITYLATION","MODCOLOR":"UBIQUITYLATION","allNum":0},{"ID":"K511","REF":1,"LTP":0,"HTP":1,"POS":511,"NMER":"ANHLIkV<font color=#993333>k</font>LEGHELP","PUBMED":72604435,"MODIFICATION":"ACETYLATION","MODCOLOR":"ACETYLATION","allNum":0}]" /> <param id="Domains" name="Domains" value="[{"ID":"","PFAM":"","START":1,"END":534},{"ID":"EHD_N","PFAM":"PF16880","START":24,"END":56},{"ID":"EF-hand_4","PFAM":"PF12763","START":439,"END":533},{"ID":"Dynamin_N","PFAM":"PF00350","START":61,"END":221},{"ID":"DUF5600","PFAM":"PF18150","START":288,"END":394}]" /> <param id="ProteinSequence" value="MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE" /> <param id="Mutations" value="[]" /> <param id="ProteinName" value="EHD1" /> <param id="SNPs" value="[]" /> <param id="ProteinMutationFrequencies" value="[{"cancertype":"Kidney (Clear Cell)","prop":0.24},{"cancertype":"Kidney (Chromophobe)","prop":0.0},{"cancertype":"Endometrial","prop":1.21},{"cancertype":"Glioblastoma","prop":0.0},{"cancertype":"Prostate","prop":0.0},{"cancertype":"Colorectal","prop":0.89},{"cancertype":"Thyroid","prop":0.24},{"cancertype":"Head/Neck","prop":1.43},{"cancertype":"Stomach","prop":1.38},{"cancertype":"Bladder","prop":0.0},{"cancertype":"Lung (Squamous)","prop":0.0},{"cancertype":"Leukemia","prop":0.0},{"cancertype":"Lung adenocarcinoma","prop":0.43},{"cancertype":"Ovarian","prop":0.32},{"cancertype":"Breast","prop":0.61}]" /> <div id="proteincartoon" style="width:800px;height:400px;float:left;"></div> <div id="controlpanel" style="width:200px;height:400px;float:left;"> <div style="font:12px Verdana;font-weight:bold;">Show on y-axis <a href="#plot" id="minimizePlot" title="Minimize Lollipop Plot" class="doubleCircleButton" style="float:right;">-</a> </div> <div style="font:12px Verdana;"> <form id="form"> <input type="radio" name="d3yaxis" value="REF" checked="checked">References (<abbr title="HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.">HTP</abbr> + <abbr title="LTP (Low Throughput Papers): The number of records in which this modification site was determined using methods other than discovery mass spectrometry.">LTP</abbr>)</input></br> <input type="radio" name="d3yaxis" value="LTP">References (<abbr title="LTP (Low Throughput Papers): The number of records in which this modification site was determined using methods other than discovery mass spectrometry.">LTP</abbr>)</input><br> <input type="radio" name="d3yaxis" value="HTP">References (<abbr title="HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.">HTP</abbr>)</input><br> </form> </div> <div style="font:12px Verdana;"> <input type="checkbox" id="logTransformation"> log2 Transformation<br/> </div> <br/> <div style="font:12px Verdana;font-weight:bold;">Filter PTM sites</div> <div style="font:12px Verdana;"> <input type="checkbox" id="refFilter"> Minimum 5 References </div> <br/> <div style="font:12px Verdana;font-weight:bold;">Add Disease Variants</div> <div style="font:12px Verdana;"> <input type="checkbox" id="showmutations"> <highlightred>Somatic Cancer Mutations</highlightred><br/> <input type="checkbox" id="showSNPs"> <highlightpurple>Germline Disease SNPs</highlightpurple><br/> </div> <br/> <div style="font:12px Verdana;font-weight:bold;">Legend: PTM sites</div> <div id="legend" width="200" heigt="100"></div> </div> <div style="width:1000px;"> <span style="width:950px; height:2px;float:left"> </span> <a href="#plot" id="maximizePlot" title="Maximize Lollipop Plot" class="doubleCircleButton" style="float:right;display: none;">+</a> </div> <script language="JavaScript" type="text/javascript" src="/dist/6.7.5_1/js/lollipop.js"></script> <br/> <div id="tabs1" style="margin-left:10px; margin-bottom:10px; width: 990px; overflow: hidden;"> <ul> <li> <a href='../overviewExecuteAction?id=4599&showAllSites=true'>Protein Information</a> </li> <li> <a href='../siteTableNewAction?id=4599&showAllSites=true'>Site Table</a> </li> <li> <a href='../upstreamActionExecute?id=4599'>Upstream</a> </li> <li> <a href='../downstreamActionExecute?id=4599'>Downstream</a> </li> <li><a href="#disease">Cancer</a></li> <li> <a href="../showMsaAction?protGroup=301942&showAllSites=true">Conservation</a> </li> <li style="float: right; padding-right: 10px; padding-top:5px"> <span id="showModSitesPopUp" onclick="return false;" style="display:none" onmouseover="showDivById('Show_Modification_Legend')" onmouseout="hideDivById('Show_Modification_Legend')" class="link12Red">Show Modification Abbreviations</span> <div id='Show_Modification_Legend' class="popupInfo" style="display:none; visibility: visible"> <table> <tr> <td><span class="popupInfoItem">p</span></td> <td><span class="popupInfoItem">Phosphorylation</span></td> </tr> <tr> <td><span class="popupInfoItem">ac</span></td> <td><span class="popupInfoItem">Acetylation</span></td> </tr> <tr> <td><span class="popupInfoItem">me</span></td> <td><span class="popupInfoItem">Methylation</span></td> </tr> <tr> <td><span class="popupInfoItem">m1</span></td> <td><span class="popupInfoItem">Mono-methylation</span></td> </tr> <tr> <td><span class="popupInfoItem">m2</span></td> <td><span class="popupInfoItem">Di-methylation</span></td> </tr> <tr> <td><span class="popupInfoItem">m3</span></td> <td><span class="popupInfoItem">Tri-methylation</span></td> </tr> <tr> <td><span class="popupInfoItem">ub</span></td> <td><span class="popupInfoItem">Ubiquitylation</span></td> </tr> <tr> <td><span class="popupInfoItem">sm</span></td> <td><span class="popupInfoItem">Sumoylation</span></td> </tr> <tr> <td><span class="popupInfoItem">ne</span></td> <td><span class="popupInfoItem">Neddylation</span></td> </tr> <tr> <td><span class="popupInfoItem">gl</span></td> <td><span class="popupInfoItem">O-GlcNAc</span></td> </tr> <tr> <td><span class="popupInfoItem">ga</span></td> <td><span class="popupInfoItem">O-GalNAc</span></td> </tr> <tr> <td><span class="popupInfoItem">pa</span></td> <td><span class="popupInfoItem">Palmitoylation</span></td> </tr> <tr> <td><span class="popupInfoItem">ad</span></td> <td><span class="popupInfoItem">Adenylation</span></td> </tr> <tr> <td><span class="popupInfoItem">sn</span></td> <td><span class="popupInfoItem">S-Nitrosylation</span></td> </tr> <tr> <td><span class="popupInfoItem">ca</span></td> <td><span class="popupInfoItem">Caspase cleavage</span></td> </tr> <tr> <td><span class="popupInfoItem">sc</span></td> <td><span class="popupInfoItem">Succinylation</span></td> </tr> <tr> <td><span class="popupInfoItem">ng</span></td> <td><span class="popupInfoItem">N-Glycosylation</span></td> </tr> <tr> <td><span class="popupInfoItem">n-ub</span></td> <td><span class="popupInfoItem">N-terminal Ubiquitylation</span></td> </tr> <tr> <td><span class="popupInfoItem">og</span></td> <td><span class="popupInfoItem">O-Glycosylation</span></td> </tr> <tr> <td><span class="popupInfoItem">Cit</span></td> <td><span class="popupInfoItem">Citrullination</span></td> </tr> <tr> <td><span class="popupInfoItem">hy</span></td> <td><span class="popupInfoItem">Hydroxylation</span></td> </tr> <tr> <td><span class="popupInfoItem">cro</span></td> <td><span class="popupInfoItem">Crotonylation</span></td> </tr> </table> </div> </li> </ul> <div id="disease"> <h3>Protein Mutation Frequency in Cancer</h3> <p> The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on 'Show Cancer Mutations'). The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. </p> </br> <p> <div id="diseaseBarplot" style="width:900px;height:400px;float:none;"></div> <script language="JavaScript" type="text/javascript" src="/dist/6.7.5_1/js/disease.js"></script> </p> <p> <span class="showMoreText"> Learn more about the integration of cancer data in PhosphoSitePlus: <br> We integrated 4440 tumor samples from 15 cancer types from TCGA (<a href="https://cancergenome.nih.gov/" target="_blank">The Cancer Genome Atlas</a>). To retrieve more detailed mutation information, we recommend <a href="http://www.cbioportal.org" target="_blank">cBioPortal</a>.<br> </br>We integrated the following cancer types: <br> <table style="padding-left:10px"> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/23634996" target="_blank">Acute Myeloid Leukemia (TCGA, NEJM 2013)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/24476821" target="_blank">Bladder Urothelial Carcinoma (TCGA, Nature 2014)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/26451490" target="_blank">Breast Invasive Carcinoma (TCGA, Cell 2015)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/22810696" target="_blank">Colorectal Adenocarcinoma (TCGA, Nature 2012)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/24120142" target="_blank">Glioblastoma (TCGA, Cell 2013)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/25631445" target="_blank">Head and Neck Squamous Cell Carcinoma (TCGA, Nature 2015)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/25155756" target="_blank">Kidney Chromophobe (TCGA, Cancer Cell 2014)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/23792563" target="_blank">Kidney Renal Clear Cell Carcinoma (TCGA, Nature 2013)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/25079552" target="_blank">Lung Adenocarcinoma (TCGA, Nature 2014)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/22960745" target="_blank">Lung Squamous Cell Carcinoma (TCGA, Nature 2012)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/21720365" target="_blank">Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/25417114" target="_blank">Papillary Thyroid Carcinoma (TCGA, Cell 2014)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/26544944" target="_blank">Prostate Adenocarcinoma (TCGA, Cell 2015)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/25079317" target="_blank">Stomach Adenocarcinoma (TCGA, Nature 2014)</a></td></tr> <tr><td>• <a href="https://www.ncbi.nlm.nih.gov/pubmed/23636398" target="_blank">Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013)</a></td></tr> </table> </span> </p> </div> </div> </div> <style type="text/css"> .footer { display: none; 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