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0.302066C9.55948 0.167276 9.37264 0.0839844 9.16634 0.0839844H0.833008C0.418794 0.0839844 0.0830078 0.419771 0.0830078 0.833984C0.0830078 1.2482 0.418794 1.58398 0.833008 1.58398H7.35568L0.302678 8.63699C0.0097845 8.92988 0.0097845 9.40475 0.302678 9.69765C0.595571 9.99054 1.07044 9.99054 1.36334 9.69765L8.41634 2.64464V9.16732C8.41634 9.58153 8.75213 9.91732 9.16634 9.91732C9.58055 9.91732 9.91634 9.58153 9.91634 9.16732V0.833984C9.91634 0.732292 9.8961 0.635327 9.85943 0.546897Z" fill="currentColor"></path></svg></div></div></a></div></div></div></div><section class="section_clinical-hero hide"><div class="padding-global"><div class="container-large"><div class="padding-bottom padding-section-xxlarge"></div><div class="padding-bottom padding-section-xxlarge"></div><div class="max-width-xlarge"><h1 class="heading-style-h1">Clinical Research</h1></div><div class="padding-bottom padding-large hide-mobile-landscape"></div><div class="padding-bottom padding-section-xxlarge"></div></div></div></section><section class="section_clinical-hero"><div class="padding-global"><div class="container-large"><div class="interior-hero_content"><div class="max-width-xlarge"><h1 class="heading-style-h1">Clinical Research</h1></div></div></div></div></section><div data-w-id="83507e6e-86e6-3e15-befe-2dd996e0bb97" class="sections-wrapper"><section id="technology" class="section_clinical-publications"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div class="clinical-publications_content"><div class="clinical-publications_header"><div><h2>Publications</h2></div><div><div class="padding-bottom padding-xxsmall"></div><p>Our publications showcase our innovative clinical research methods leveraging trial participants’ digital twins to deliver faster, more powerful clinical studies.</p></div></div><div class="padding-bottom padding-section-large"></div><div class="whitepaper-banner_wrapper"><h2 class="text-style-label">Whitepaper</h2><div class="padding-bottom padding-large"></div><div class="whitepaper-banner_layout"><div class="max-width-large"><h3 class="heading-style-h3">How to Position Clinical Trials with Digital Twins for Regulatory Success</h3></div><a data-w-id="44a9a226-66b0-de37-3a2c-0bf44f52fd7b" href="https://www.unlearn.ai/forms/how-to-position-clinical-trials-with-digital-twins-for-regulatory-success" target="_blank" class="button w-inline-block"><div class="button_text">Download</div><img src="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5845_button-blur.png" loading="lazy" width="290" style="-webkit-transform:translate3d(0%, 0%, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);-moz-transform:translate3d(0%, 0%, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);-ms-transform:translate3d(0%, 0%, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0);transform:translate3d(0%, 0%, 0) scale3d(1, 1, 1) rotateX(0) rotateY(0) rotateZ(0) skew(0, 0)" alt="" class="button-blur"/></a></div></div><div class="padding-bottom padding-section-large"></div><div class="clinical-publications_body"><div class="publications_list-wrapper w-dyn-list"><div role="list" class="publications_list w-dyn-items"><div role="listitem" class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2404.17576" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Enhancing Longitudinal Clinical Trial Efficiency with Digital Twins and Prognostic Covariate-Adjusted Mixed Models for Repeated Measures (PROCOVA-MMRM)</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">April 26, 2024</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2404.17576" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div><div role="listitem" class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://www.unlearn.ai/forms/how-to-position-clinical-trials-with-digital-twins-for-regulatory-success" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">How to position clinical trials with digital twins for regulatory success</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">Unlearn</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">February 6, 2024</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://www.unlearn.ai/forms/how-to-position-clinical-trials-with-digital-twins-for-regulatory-success" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div><div role="listitem" class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2310.18027" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Bayesian Prognostic Covariate Adjustment With Additive Mixture Priors</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">November 23, 2023</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2310.18027" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 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</svg></div></a></div></div></div></div><div role="listitem" class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2309.14256" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">A Weighted Prognostic Covariate Adjustment Method for Efficient and Powerful Treatment Effect Inferences in Randomized Controlled Trials</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">September 25, 2023</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2309.14256" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div><div role="listitem" class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.065386" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Evaluating Digital Twins for Alzheimer’s Disease using Data from a Completed Phase 2 Clinical Trial</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">Alzheimer’s Association</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">December 20, 2022</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.065386" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 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class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2212.09903" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Prognostic Covariate Adjustment for Binary Outcomes Using Stratification</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">December 19, 2022</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2212.09903" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div><div role="listitem" class="publications_list-item w-dyn-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2208.04495" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Restricted mean survival time estimate using covariate adjusted pseudovalue regression to improve precision</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">August 9, 2022</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2208.04495" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 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w-inline-block"><div class="heading-style-h5">Increasing the efficiency of randomized trial estimates via linear adjustment for a prognostic score</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">De Gruyter</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">December 22, 2021</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://pubmed.ncbi.nlm.nih.gov/34957728/" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 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padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f3-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f5-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f6-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f8-fb4d57c6" class="publications-card_meta-value">December 24, 2020</div></div><div id="w-node-_6315f24d-eca0-9fe4-6ab4-70026bfd14f9-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2012.13112" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 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19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div></div></div><div class="publications_list-wrapper hide"><ul role="list" class="publications_list"><li id="w-node-_523f00ea-02eb-1977-2e22-10e4fdb90508-fb4d57c6" class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2310.18027" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">How to position clinical trials with digital twins for regulatory success</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_523f00ea-02eb-1977-2e22-10e4fdb90511-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_523f00ea-02eb-1977-2e22-10e4fdb90513-fb4d57c6" class="publications-card_meta-value">Unlearn</div><div id="w-node-_523f00ea-02eb-1977-2e22-10e4fdb90515-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_523f00ea-02eb-1977-2e22-10e4fdb90517-fb4d57c6" class="publications-card_meta-value">February 6, 2024</div></div><div id="w-node-_523f00ea-02eb-1977-2e22-10e4fdb90519-fb4d57c6" class="publications-card_button-wrapper"><a href="http://www.unlearn.ai/forms/how-to-position-clinical-trials-with-digital-twins-for-regulatory-success" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 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18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2310.18027" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Bayesian Prognostic Covariate Adjustment With Additive Mixture Priors</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-a160e302-c335-a574-8d6d-e883b42cb2e8-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-a160e302-c335-a574-8d6d-e883b42cb2ea-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-a160e302-c335-a574-8d6d-e883b42cb2ec-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-a160e302-c335-a574-8d6d-e883b42cb2ee-fb4d57c6" class="publications-card_meta-value">November 23, 2023</div></div><div id="w-node-a160e302-c335-a574-8d6d-e883b42cb2f0-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2310.18027" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2309.14256" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">A Weighted Prognostic Covariate Adjustment Method for Efficient and Powerful Treatment Effect Inferences in Randomized Controlled Trials</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_48194fa3-a1c9-ba96-c262-2cd4a3f8633e-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_48194fa3-a1c9-ba96-c262-2cd4a3f86340-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_48194fa3-a1c9-ba96-c262-2cd4a3f86342-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_48194fa3-a1c9-ba96-c262-2cd4a3f86344-fb4d57c6" class="publications-card_meta-value">September 25, 2023</div></div><div id="w-node-_48194fa3-a1c9-ba96-c262-2cd4a3f86346-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2309.14256" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.065386" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Evaluating Digital Twins for Alzheimer’s Disease using Data from a Completed Phase 2 Clinical Trial</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-fd5438f1-1fdd-1dad-e88d-75dcf74bbb0a-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-fd5438f1-1fdd-1dad-e88d-75dcf74bbb0c-fb4d57c6" class="publications-card_meta-value">Alzheimer’s Association</div><div id="w-node-fd5438f1-1fdd-1dad-e88d-75dcf74bbb0e-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-fd5438f1-1fdd-1dad-e88d-75dcf74bbb10-fb4d57c6" class="publications-card_meta-value">December 20, 2022</div></div><div id="w-node-fd5438f1-1fdd-1dad-e88d-75dcf74bbb12-fb4d57c6" class="publications-card_button-wrapper"><a href="https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.065386" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2212.09903" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Prognostic Covariate Adjustment for Binary Outcomes Using Stratification</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_1a47e39e-a060-671f-8bd2-b05fe149225c-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_1a47e39e-a060-671f-8bd2-b05fe149225e-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_1a47e39e-a060-671f-8bd2-b05fe1492260-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_1a47e39e-a060-671f-8bd2-b05fe1492262-fb4d57c6" class="publications-card_meta-value">December 19, 2022</div></div><div id="w-node-_1a47e39e-a060-671f-8bd2-b05fe1492264-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2212.09903" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2208.04495" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Restricted mean survival time estimate using covariate adjusted pseudovalue regression to improve precision</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_77cb8db6-0b06-2ba9-d8d4-56b71d6a42db-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_77cb8db6-0b06-2ba9-d8d4-56b71d6a42dd-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_77cb8db6-0b06-2ba9-d8d4-56b71d6a42df-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_77cb8db6-0b06-2ba9-d8d4-56b71d6a42e1-fb4d57c6" class="publications-card_meta-value">August 9, 2022</div></div><div id="w-node-_77cb8db6-0b06-2ba9-d8d4-56b71d6a42e3-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2208.04495" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://pubmed.ncbi.nlm.nih.gov/34957728/" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Increasing the efficiency of randomized trial estimates via linear adjustment for a prognostic score</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_2e10974a-9f4f-1224-6c16-503c43b8b1be-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_2e10974a-9f4f-1224-6c16-503c43b8b1c0-fb4d57c6" class="publications-card_meta-value">De Gruyter</div><div id="w-node-_2e10974a-9f4f-1224-6c16-503c43b8b1c2-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_2e10974a-9f4f-1224-6c16-503c43b8b1c4-fb4d57c6" class="publications-card_meta-value">December 22, 2021</div></div><div id="w-node-_2e10974a-9f4f-1224-6c16-503c43b8b1c6-fb4d57c6" class="publications-card_button-wrapper"><a href="https://pubmed.ncbi.nlm.nih.gov/34957728/" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li><li class="publications_list-item"><div class="publications-card_component"><div class="publications-card_body"><a href="https://arxiv.org/abs/2012.13112" target="_blank" class="publications-card_heading-wrapper w-inline-block"><div class="heading-style-h5">Bayesian prognostic covariate adjustment</div></a></div><div class="padding-bottom padding-large"></div><div class="publications-card_footer"><div class="publications-card_meta"><div id="w-node-_7247e40b-f833-4584-a78f-9ad1b70c8f89-fb4d57c6" class="publications-card_meta-title">Publisher</div><div id="w-node-_7247e40b-f833-4584-a78f-9ad1b70c8f8b-fb4d57c6" class="publications-card_meta-value">arXiv</div><div id="w-node-_7247e40b-f833-4584-a78f-9ad1b70c8f8d-fb4d57c6" class="publications-card_meta-title">Date</div><div id="w-node-_7247e40b-f833-4584-a78f-9ad1b70c8f8f-fb4d57c6" class="publications-card_meta-value">December 24, 2020</div></div><div id="w-node-_7247e40b-f833-4584-a78f-9ad1b70c8f91-fb4d57c6" class="publications-card_button-wrapper"><a href="https://arxiv.org/abs/2012.13112" target="_blank" class="publications-card_button w-inline-block"><div class="publications-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></li></ul></div></div></div></div></div></div></section><section id="technology" class="section_clinical-blog"><div class="padding-global"><div class="container-large"><div class="padding-section-large"><div class="clinical-blog_content"><div class="clinical-blog_header"><h2 class="text-style-label">Blog</h2><div class="padding-bottom padding-medium"></div><h3 class="is-blue_background">Our perspectives</h3><div class="padding-bottom padding-large"></div><a href="/blog" class="text-size-large text-style-link">View all</a></div><div class="padding-bottom padding-section-large"></div><div class="clinical-blog_body"><ul id="w-node-b800d958-c5ab-4f30-1a33-6099874ace18-fb4d57c6" role="list" class="clinical-blog_list"><li class="clinical-blog_list-item"><div class="blog-card_component"><div class="blog-card_header"><div class="blog-card_image-wrapper"><img src="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d597c_blog-card-thumbnail_reducing-placebo-burden.webp" loading="lazy" sizes="(max-width: 767px) 92vw, (max-width: 991px) 45vw, (max-width: 1919px) 29vw, 410.6640625px" srcset="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d597c_blog-card-thumbnail_reducing-placebo-burden-p-500.webp 500w, https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d597c_blog-card-thumbnail_reducing-placebo-burden-p-800.webp 800w, https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d597c_blog-card-thumbnail_reducing-placebo-burden.webp 970w" alt="" class="blog-card_image"/></div></div><div class="blog-card_body is-blue-background_card"><a href="https://www.unlearn.ai/blog/reducing-placebo-burden-twinrcts-and-their-impact-on-clinical-trials" target="_blank" class="blog-card_heading-wrapper w-inline-block"><div class="heading-style-h6">Reducing Placebo Burden: TwinRCTs and Their Impact on Clinical Trials</div></a><div class="padding-bottom padding-xsmall"></div><div class="blog-card_footer"><div class="blog-card_meta"><div id="w-node-d689abe5-b8c6-e549-409b-e1e85be53be3-fb4d57c6" class="blog-card_meta-title">Date</div><div id="w-node-d689abe5-b8c6-e549-409b-e1e85be53be5-fb4d57c6" class="blog-card_meta-value">January 2, 2024</div></div><div class="blog-card_button-wrapper"><a href="https://www.unlearn.ai/blog/reducing-placebo-burden-twinrcts-and-their-impact-on-clinical-trials" class="card_button w-inline-block"><div class="blog-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div></li><li class="clinical-blog_list-item"><div class="blog-card_component"><div class="blog-card_header"><div class="blog-card_image-wrapper"><img src="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5989_blog-card-thumbnail_synthetic-control-groups.webp" loading="lazy" sizes="(max-width: 767px) 92vw, (max-width: 991px) 45vw, (max-width: 1919px) 29vw, 410.6640625px" srcset="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5989_blog-card-thumbnail_synthetic-control-groups-p-500.webp 500w, https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5989_blog-card-thumbnail_synthetic-control-groups-p-800.webp 800w, https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5989_blog-card-thumbnail_synthetic-control-groups.webp 972w" alt="" class="blog-card_image"/></div></div><div class="blog-card_body is-blue-background_card"><a href="https://www.unlearn.ai/blog/synthetic-control-groups-dont-work-or-how-i-learned-to-stop-worrying-and-love-randomized-trials" class="blog-card_heading-wrapper w-inline-block"><div class="heading-style-h6">Synthetic Control Groups Don’t Work, or: How I Learned to Stop Worrying and Love Randomized Trials</div></a><div class="padding-bottom padding-xsmall"></div><div class="blog-card_footer"><div class="blog-card_meta"><div id="w-node-d09b8675-ecfe-1491-2159-09a2fa875270-fb4d57c6" class="blog-card_meta-title">Date</div><div id="w-node-d09b8675-ecfe-1491-2159-09a2fa875272-fb4d57c6" class="blog-card_meta-value">May 30, 2023</div></div><div class="blog-card_button-wrapper"><a href="https://www.unlearn.ai/blog/synthetic-control-groups-dont-work-or-how-i-learned-to-stop-worrying-and-love-randomized-trials" class="card_button w-inline-block"><div class="blog-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 8.88831 19.5338 8.6575 19.321 8.46957L9.99541 0.271417C9.75452 0.0744488 9.44648 -0.0214162 9.13621 0.00402553C8.82594 0.0294672 8.53767 0.174228 8.33217 0.4078C8.12666 0.641373 8.01997 0.945512 8.03456 1.25612C8.04916 1.56673 8.18392 1.85955 8.41043 2.07286L15.6154 8.40541C15.647 8.43341 15.6694 8.47034 15.6795 8.5113C15.6896 8.55227 15.687 8.59534 15.6721 8.63481C15.6572 8.67428 15.6306 8.7083 15.5959 8.73236C15.5612 8.75641 15.52 8.76938 15.4778 8.76953H1.20125C0.88266 8.76953 0.577117 8.89595 0.351838 9.12096C0.12656 9.34598 0 9.65116 0 9.96938C0 10.2876 0.12656 10.5928 0.351838 10.8178C0.577117 11.0428 0.88266 11.1692 1.20125 11.1692H15.4753C15.5175 11.1696 15.5586 11.1828 15.5932 11.207C15.6278 11.2311 15.6543 11.2652 15.6692 11.3046C15.6841 11.3441 15.6867 11.3872 15.6766 11.4281C15.6666 11.4691 15.6444 11.5061 15.6129 11.5342L8.40792 17.8667C8.28192 17.9684 8.1778 18.0945 8.10182 18.2373C8.02584 18.3802 7.97958 18.537 7.96582 18.6982C7.95205 18.8594 7.97107 19.0217 8.02173 19.1754C8.07238 19.3291 8.15363 19.4709 8.26058 19.5924C8.36753 19.7139 8.49798 19.8126 8.64408 19.8824C8.79019 19.9523 8.94892 19.9919 9.11074 19.9989C9.27257 20.0059 9.43414 19.9801 9.58574 19.9231C9.73734 19.8662 9.87584 19.7792 9.99291 19.6674L19.3201 11.4692C19.5332 11.2814 19.7039 11.0506 19.8211 10.7921C19.9383 10.5336 19.9993 10.2532 20 9.96938Z" fill="currentColor"/> </svg></div></a></div></div></div></div></li><li class="clinical-blog_list-item"><div class="blog-card_component"><div class="blog-card_header"><div class="blog-card_image-wrapper"><img src="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5988_blog-card-thumbnail_digital-twins-in-clinical-trials.webp" loading="lazy" sizes="(max-width: 767px) 92vw, (max-width: 991px) 45vw, (max-width: 1919px) 29vw, 410.6640625px" srcset="https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5988_blog-card-thumbnail_digital-twins-in-clinical-trials-p-500.webp 500w, https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5988_blog-card-thumbnail_digital-twins-in-clinical-trials-p-800.webp 800w, https://cdn.prod.website-files.com/66fc2ff3074bb309fb4d56fc/66fc2ff3074bb309fb4d5988_blog-card-thumbnail_digital-twins-in-clinical-trials.webp 972w" alt="" class="blog-card_image"/></div></div><div class="blog-card_body is-blue-background_card"><a href="https://www.unlearn.ai/blog/digital-twins-in-clinical-trials-how-they-work-and-how-they-dont" class="blog-card_heading-wrapper w-inline-block"><div class="heading-style-h6">Digital twins in clinical trials: How they work, and how they don’t.</div></a><div class="padding-bottom padding-xsmall"></div><div class="blog-card_footer"><div class="blog-card_meta"><div id="w-node-_72babe8e-a709-09a1-8d84-c04518d6b943-fb4d57c6" class="blog-card_meta-title">Date</div><div id="w-node-_72babe8e-a709-09a1-8d84-c04518d6b945-fb4d57c6" class="blog-card_meta-value">March 31, 2022</div></div><div class="blog-card_button-wrapper"><a href="https://www.unlearn.ai/blog/digital-twins-in-clinical-trials-how-they-work-and-how-they-dont" class="card_button w-inline-block"><div class="blog-card_button-icon w-embed"><svg xmlns="http://www.w3.org/2000/svg" width="20" viewBox="0 0 20 20" fill="none"> <path d="M20 9.96938C19.9993 9.68567 19.9384 9.40533 19.8213 9.14682C19.7043 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