{"title":"Analysis of OPG Gene Polymorphism T245G (rs3134069) in Slovak Postmenopausal Women","authors":"I. Boro\u0148ov\u00e1, J. Bernasovsk\u00e1, J. K\u013eoc, Z. Tomkov\u00e1, E. Petrej\u010d\u00edkov\u00e1, S. Ma\u010dekov\u00e1, J. Por\u00e1\u010dov\u00e1, M. M. Bla\u0161\u010d\u00e1kov\u00e1","volume":93,"journal":"International Journal of Bioengineering and Life Sciences","pagesStart":600,"pagesEnd":604,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/9999452","abstract":"<p>Osteoporosis is a common multifactorial disease with<br \/>\r\na strong genetic component characterized by reduced bone mass and<br \/>\r\nincreased risk of fractures. Genetic factors play an important role in<br \/>\r\nthe pathogenesis of osteoporosis. The aim of our study was to<br \/>\r\nidentify the genotype and allele distribution of T245G polymorphism<br \/>\r\nin OPG gene in Slovak postmenopausal women. A total of 200<br \/>\r\nunrelated Slovak postmenopausal women with diagnosed<br \/>\r\nosteoporosis and 200 normal controls were genotyped for T245G<br \/>\r\n(rs3134069) polymorphism of OPG gene. Genotyping was performed<br \/>\r\nusing the Custom Taqman&reg;SNP Genotyping assays. Genotypes and<br \/>\r\nalleles frequencies showed no significant differences (p=0.5551;<br \/>\r\np=0.6022). The results of the present study confirm the importance of<br \/>\r\nT245G polymorphism in OPG gene in the pathogenesis of<br \/>\r\nosteoporosis.<\/p>\r\n","references":"[1] B. Arko, J. Prezelj, R. Komel, A. Kocijancic, P. Hudler, J. Marc\r\n\"Sequence variations in the osteoprotegerin gene promoter in patients\r\nwith postmenopausal osteoporosis\". In J Clin Endocrinol Metab 2002,\r\n87(9): 4080\u20134084.\r\n[2] H. Brandstrom, P. Gerdhem, F. 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