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Small Molecules & TPD World Series - Covalent Drug Discovery & Development Summit

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itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-24144 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="24144"><div class="fl-row fl-row-full-width fl-row-bg-photo fl-node-p1o4qkxvnibg fl-row-default-height fl-row-align-center" data-node="p1o4qkxvnibg"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-d3zt718lwy0s" data-node="d3zt718lwy0s"> <div class="fl-col fl-node-esibmd6npljg fl-col-bg-color" data-node="esibmd6npljg"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-681mwki9qtz5" data-node="681mwki9qtz5"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">Small Molecules & TPD World Series</span> </h2> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-dxekbcgm8uy0 fl-row-default-height fl-row-align-center" data-node="dxekbcgm8uy0"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-384pe1dqtinc" data-node="384pe1dqtinc"> <div class="fl-col fl-node-rpk0w65q9svc fl-col-bg-color fl-col-has-cols" data-node="rpk0w65q9svc"> <div class="fl-col-content fl-node-content"> <div class="fl-col-group fl-node-rya40wplj5t7 fl-col-group-nested" data-node="rya40wplj5t7"> <div class="fl-col fl-node-b0v3yltqpdsf fl-col-bg-color" data-node="b0v3yltqpdsf"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-rich-text fl-node-j5tncdm6rklh" data-node="j5tncdm6rklh"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><span style="font-size: 16px;">The <strong>Small Molecules and TPD World Series</strong> is committed to delivering the most comprehensive collection of industry-dedicated forums, exclusively focusing on the specific challenges faced for each community of small molecules and protein degradation drug developers.</span></p> <p><span style="font-size: 16px;">The goal for this event series is to provide your team with the platform to connect, learn and fast-track first-in-class or next generation of selective, orally bioavailable and clinically efficacious small molecules for undrugged or hard-to-drug targets to meet the needs of patients globally.</span></p> <p><span style="font-size: 16px;">View the<strong> Small Molecules &amp; TPD World Series</strong> conference calendar below. If you have any questions, get in touch at <a href="mailto:info@hansonwade.com?subject=Small%20Molecules%20%26%20TPD%20World%20Series%20-%20Enquiry">info@hansonwade.com</a>.</span></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-zb0qgfp9my3t" data-node="zb0qgfp9my3t"> <div class="fl-col fl-node-keibyl6jv7cn fl-col-bg-color" data-node="keibyl6jv7cn"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-separator fl-node-ohl0eq9ywb6x" data-node="ohl0eq9ywb6x"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-mo8sckbd57n9 fl-row-default-height fl-row-align-center" data-node="mo8sckbd57n9"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-tvew76q8ulfg" data-node="tvew76q8ulfg"> <div class="fl-col fl-node-rpz3gfd02tcx fl-col-bg-color fl-col-has-cols" data-node="rpz3gfd02tcx"> <div class="fl-col-content fl-node-content"> <div class="fl-col-group fl-node-ofdg0xvc58hz fl-col-group-nested fl-col-group-equal-height fl-col-group-align-top" data-node="ofdg0xvc58hz"> <div class="fl-col fl-node-i28cfjxsqyho fl-col-bg-color fl-col-small" data-node="i28cfjxsqyho"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-p0y9n87xuvad fl-animation fl-fade-up" data-node="p0y9n87xuvad" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img fetchpriority="high" decoding="async" class="fl-photo-img wp-image-22584 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/Induced-Proximity-1.png" alt="Induced Proximity" itemprop="image" height="440" width="2048" title="Induced Proximity" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-w3b74lfuig1e" data-node="w3b74lfuig1e"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Successfully Screen &amp; Validate Novel Protein-Protein Inducing Mechanisms &amp; Chemical Matters to Improve the Selectivity &amp; Off-Target Effect of Your Degrader &amp; Non-Degrader Proximity-Based Drugs from Discovery to Clinic</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-maf2j6471pwu" data-node="maf2j6471pwu"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-glt73u4oxipk" data-node="glt73u4oxipk"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>July 23-25, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://induced-proximity-summit.com/?utm_source=internal&amp;utm_medium=event&amp;utm_campaign=conference&amp;utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #1945b1;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-2tqosugw4ep5 fl-col-bg-color fl-col-small" data-node="2tqosugw4ep5"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-qex2915sb0g3 fl-animation fl-fade-up" data-node="qex2915sb0g3" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-21863 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2023/12/21516-6th-RAS-Targeted-Drug-Discovery-Summit-logo.png" alt="21516 6th RAS Targeted Drug Discovery Summit logo" itemprop="image" height="1928" width="7576" title="21516 6th RAS Targeted Drug Discovery Summit logo" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-ce8ga0z1nhvo" data-node="ce8ga0z1nhvo"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Overcome Diverse Clinical Resistance Mechanisms with Emerging First- &amp; Best-In-Class Combination &amp; Monotherapies to Effectively Treat Patients with RAS-Driven Lung, Colorectal &amp; Pancreatic Cancers</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-0zlhey8s9ruo" data-node="0zlhey8s9ruo"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-1q7d4g5if8bp" data-node="1q7d4g5if8bp"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>September 24-26, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://ras-drugdevelopment.com/?utm_source=internal&amp;utm_medium=event&amp;utm_campaign=conference&amp;utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #d82763;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-5g43cnluyivf fl-col-group-nested fl-col-group-equal-height fl-col-group-align-top" data-node="5g43cnluyivf"> <div class="fl-col fl-node-0thel3fwkano fl-col-bg-color fl-col-small" data-node="0thel3fwkano"> <div class="fl-col-content fl-node-content"><div id="europe" class="fl-module fl-module-photo fl-node-it9jxb7los3g fl-animation fl-fade-up" data-node="it9jxb7los3g" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22586 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/TPD-US.png" alt="TPD US" itemprop="image" height="515" width="2048" title="TPD US" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-5b16mys7jp2h" data-node="5b16mys7jp2h"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Fast-Track Discovery, Development &amp; Approval of Selective, Safe &amp; Clinically Relevant TACs &amp; Glues for Degradation, Stabilization, &amp; Phosphorylation to Successfully Address Unmet Need in Oncology &amp; Beyond</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-xboyv13tns5z" data-node="xboyv13tns5z"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-dhx67bwak8y4" data-node="dhx67bwak8y4"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>October 29-31, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://proteindegradation.com/?utm_source=internal&amp;utm_medium=event&amp;utm_campaign=conference&amp;utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #1278ab;"><strong><span style="color: #019745;">LEARN MORE</span></strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-0ukpniv3j1w6 fl-col-bg-color fl-col-small" data-node="0ukpniv3j1w6"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-oq7ax3g6jivk fl-animation fl-fade-up" data-node="oq7ax3g6jivk" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22585 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/HW240707-49702-GPCRs-Targeted-Drug-Discovery-Summit-Europe-l.png" alt="GPCRs Targeted Drug Discovery Summit Europe" itemprop="image" height="1589" width="7036" title="HW240707 49702 GPCRs-Targeted Drug Discovery Summit Europe l" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-b4ga2qsf3vo7" data-node="b4ga2qsf3vo7"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Leverage Advances in Structural Biology, Screening &amp; Target Validation Whilst Overcoming Pharmacology Challenges to Successfully Translate Your Small Molecules &amp; Biologics from Novel Discoveries to Clinically Relevant &amp; Effective GPCR Drugs</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-xmrbytiw796a" data-node="xmrbytiw796a"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-251x70cve83u" data-node="251x70cve83u"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>26-28 November, 2024 | London, UK</strong></p> <p style="text-align: center;"><span style="color: #0f4c8e;"><a style="color: #0f4c8e;" href="https://ter.li/1pk8z4" target="_blank" rel="noopener"><strong>LEARN MORE</strong></a></span></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-dn7g4f1bch8m fl-col-group-nested fl-col-group-equal-height fl-col-group-align-top" data-node="dn7g4f1bch8m"> <div class="fl-col fl-node-8pg1hj2v6s09 fl-col-bg-color fl-col-small" data-node="8pg1hj2v6s09"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-zqd015hfe3ol fl-animation fl-fade-up" data-node="zqd015hfe3ol" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22582 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/Hippo-Pathway-Targeted-Drug-Development-Summit-Strapline.png" alt="Hippo-Pathway-Targeted-Drug-Development-Summit" itemprop="image" height="683" width="3366" title="Hippo Pathway Targeted Drug Development Summit Strapline" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-avjszro59m0n" data-node="avjszro59m0n"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p class="fl-heading" style="text-align: center;">Improve Selectivity, Reduce Toxicity &amp; Overcome Limitations of Preclinical Models &amp; Clinical Biomarkers to Accelerate Translation &amp; Development of Hippo Pathway Targeted Therapeutics for Patients</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-myivk3o69a7b" data-node="myivk3o69a7b"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-csrz3u2y7l5t" data-node="csrz3u2y7l5t"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong><span class="fl-heading-text">November, 2024 | Virtual</span></strong></p> <p>&nbsp;</p> <p style="text-align: center;"><a href="https://hippo-pathway.com/?utm_source=internal&amp;utm_medium=event&amp;utm_campaign=conference&amp;utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #0b5d7a;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-gqop1mtluje5 fl-col-bg-color fl-col-small" data-node="gqop1mtluje5"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-ktpujqzc6ewd fl-animation fl-fade-up" data-node="ktpujqzc6ewd" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22580 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/Molecular-Glue-Drug-Development-Summit-.png" alt="Molecular Glue Drug Development Summit" itemprop="image" height="767" width="3294" title="Molecular Glue Drug Development Summit" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-mk62vh8fl0ye" data-node="mk62vh8fl0ye"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Accelerate the Discovery, Validation and Clinical Translation of Novel and Rationally Designed Molecular Glues through Systematic Screening, Expanding Ligase Toolbox and Optimizing Pharmacological Properties</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-v7hjfizoywlq" data-node="v7hjfizoywlq"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-sbzxn1ugjemy" data-node="sbzxn1ugjemy"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>Returning January, 2025 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://molecular-glue-summit.com/?utm_source=internal&amp;utm_medium=event&amp;utm_campaign=conference&amp;utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #53bac1;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-you6ckl3gpz9 fl-col-group-nested" data-node="you6ckl3gpz9"> <div class="fl-col fl-node-126xkuaej049 fl-col-bg-color fl-col-small" data-node="126xkuaej049"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-bkeijxam5yl6 fl-animation fl-fade-up" data-node="bkeijxam5yl6" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-23650 size-full" 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else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba1fe150af69',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} 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-'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} 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