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Search results for: Ryszard Krzyminiewski
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</div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Ryszard Krzyminiewski</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> PEG-b-poly(4-vinylbenzyl phosphonate) Coated Magnetic Iron Oxide Nanoparticles as Drug Carrier System: Biological and Physicochemical Characterization </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Ha%C5%82upka-Bryl">Magdalena Hałupka-Bryl</a>, <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Bednarowicz"> Magdalena Bednarowicz</a>, <a href="https://publications.waset.org/abstracts/search?q=Ryszard%20Krzyminiewski"> Ryszard Krzyminiewski</a>, <a href="https://publications.waset.org/abstracts/search?q=Yukio%20Nagasaki"> Yukio Nagasaki </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to their unique physical properties, superparamagnetic iron oxide nanoparticles are increasingly used in medical applications. They are very useful carriers for delivering antitumor drugs in targeted cancer treatment. Magnetic nanoparticles (PEG-PIONs/DOX) with chemotherapeutic were synthesized by coprecipitation method followed by coating with biocompatible polymer PEG-derivative (poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate). Complete physicochemical characterization was carried out (ESR, HRTEM, X-ray diffraction, SQUID analysis) to evaluate the magnetic properties of obtained PEG-PIONs/DOX. Nanoparticles were investigated also in terms of their stability, drug loading efficiency, drug release and antiproliferative effect on cancer cells. PEG-PIONs/DOX have been successfully used for the efficient delivery of an anticancer drug into the tumor region. Fluorescent imaging showed the internalization of PEG-PIONs/DOX in the cytoplasm. Biodistribution studies demonstrated that PEG-PIONs/DOX preferentially accumulate in tumor region via the enhanced permeability and retention effect. The present findings show that synthesized nanosystem is promising tool for potential magnetic drug delivery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=targeted%20drug%20delivery" title="targeted drug delivery">targeted drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=magnetic%20properties" title=" magnetic properties"> magnetic properties</a>, <a href="https://publications.waset.org/abstracts/search?q=iron%20oxide%20nanoparticles" title=" iron oxide nanoparticles"> iron oxide nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=biodistribution" title=" biodistribution"> biodistribution</a> </p> <a href="https://publications.waset.org/abstracts/29050/peg-b-poly4-vinylbenzyl-phosphonate-coated-magnetic-iron-oxide-nanoparticles-as-drug-carrier-system-biological-and-physicochemical-characterization" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29050.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">463</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Microstructure of Ti – AlN Composite Produced by Selective Laser Melting </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jaroslaw%20Mizera">Jaroslaw Mizera</a>, <a href="https://publications.waset.org/abstracts/search?q=Pawel%20Wisniewski"> Pawel Wisniewski</a>, <a href="https://publications.waset.org/abstracts/search?q=Ryszard%20Sitek"> Ryszard Sitek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Selective Laser Melting (SLM) is an advanced additive manufacturing technique used for producing parts made of wide range of materials such as: austenitic steel, titanium, nickel etc. In the our experiment we produced a Ti-AlN composite from a mixture of titanium and aluminum nitride respectively 70% at. and 30% at. using SLM technique. In order to define the size of powder particles, laser diffraction tests were performed on HORIBA LA-950 device. The microstructure and chemical composition of the composite was examined by Scanning Electron Microscopy (SEM). The chemical composition in micro areas of the obtained samples was determined by of EDS. The phase composition was analyzed by X-ray phase analysis (XRD). Microhardness Vickers tests were performed using Zwick/Roell microhardness machine under the load of 0.2kG (HV0.2). Hardness measurements were made along the building (xy) and along the plane of the lateral side of the cuboid (xz). The powder used for manufacturing of the samples had a mean particle size of 41μm. It was homogenous with a spherical shape. The specimens were built chiefly from Ti, TiN and AlN. The dendritic microstructure was porous and fine-grained. Some of the aluminum nitride remained unmelted but no porosity was observed in the interface. The formed material was characterized by high hardness exceeding 700 HV0.2 over the entire cross-section. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Selective%20Laser%20Melting" title="Selective Laser Melting">Selective Laser Melting</a>, <a href="https://publications.waset.org/abstracts/search?q=Composite" title=" Composite"> Composite</a>, <a href="https://publications.waset.org/abstracts/search?q=SEM" title=" SEM"> SEM</a>, <a href="https://publications.waset.org/abstracts/search?q=microhardness" title=" microhardness"> microhardness</a> </p> <a href="https://publications.waset.org/abstracts/122336/microstructure-of-ti-aln-composite-produced-by-selective-laser-melting" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/122336.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Spatiotemporal Changes in Drought Sensitivity Captured by Multiple Tree-Ring Parameters of Central European Conifers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kre%C5%A1imir%20Begovi%C4%87">Krešimir Begović</a>, <a href="https://publications.waset.org/abstracts/search?q=Milo%C5%A1%20Rydval"> Miloš Rydval</a>, <a href="https://publications.waset.org/abstracts/search?q=Jan%20Tumajer"> Jan Tumajer</a>, <a href="https://publications.waset.org/abstracts/search?q=Kristyna%20Svobodov%C3%A1"> Kristyna Svobodová</a>, <a href="https://publications.waset.org/abstracts/search?q=Thomas%20Langbehn"> Thomas Langbehn</a>, <a href="https://publications.waset.org/abstracts/search?q=Yumei%20Jiang"> Yumei Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Vojtech%20%C4%8Cada"> Vojtech Čada</a>, <a href="https://publications.waset.org/abstracts/search?q=Vaclav%20Treml"> Vaclav Treml</a>, <a href="https://publications.waset.org/abstracts/search?q=Ryszard%20Kaczka"> Ryszard Kaczka</a>, <a href="https://publications.waset.org/abstracts/search?q=Miroslav%20Svoboda"> Miroslav Svoboda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Environmental changes have increased the frequency and intensity of climatic extremes, particularly hotter droughts, leading to altered tree growth patterns and multi-year lags in tree recovery. The effects of shifting climatic conditions on tree growth are inhomogeneous across species’ natural distribution ranges, with large spatial heterogeneity and inter-population variability, but generally have significant consequences for contemporary forest dynamics and future ecosystem functioning. Despite numerous studies on the impacts of regional drought effects, large uncertainties remain regarding the mechanistic basis of drought legacy effects on wood formation and the ability of individual species to cope with increasingly drier growing conditions and rising year-to-year climatic variability. To unravel the complexity of climate-growth interactions and assess species-specific responses to severe droughts, we combined forward modeling of tree growth (VS-lite model) with correlation analyses against climate (temperature, precipitation, and the SPEI-3 moisture index) and growth responses to extreme drought events from multiple tree-ring parameters (tree-width and blue intensity parameters). We used an extensive dataset with over 1000 tree-ring samples from 23 nature forest reserves across an altitudinal range in Czechia and Slovakia. Our results revealed substantial spatiotemporal variability in growth responses to summer season temperature and moisture availability across species and tree-ring parameters. However, a general trend of increasing spring moisture-growth sensitivity in recent decades was observed in the Scots pine mountain forests and lowland forests of both species. The VS-lite model effectively captured nonstationary climate-growth relationships and accurately estimated high-frequency growth variability, indicating a significant incidence of regional drought events and growth reductions. Notably, growth reductions during extreme drought years and discrete legacy effects identified in individual wood components were most pronounced in the lowland forests. Together with the observed growth declines in recent decades, these findings suggest an increasing vulnerability of Norway spruce and Scots pine in dry lowlands under intensifying climatic constraints. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dendroclimatology" title="dendroclimatology">dendroclimatology</a>, <a href="https://publications.waset.org/abstracts/search?q=Vaganova%E2%80%93Shashkin%20lite" title=" Vaganova–Shashkin lite"> Vaganova–Shashkin lite</a>, <a href="https://publications.waset.org/abstracts/search?q=conifers" title=" conifers"> conifers</a>, <a href="https://publications.waset.org/abstracts/search?q=central%20Europe" title=" central Europe"> central Europe</a>, <a href="https://publications.waset.org/abstracts/search?q=drought" title=" drought"> drought</a>, <a href="https://publications.waset.org/abstracts/search?q=blue%20intensity" title=" blue intensity"> blue intensity</a> </p> <a href="https://publications.waset.org/abstracts/178826/spatiotemporal-changes-in-drought-sensitivity-captured-by-multiple-tree-ring-parameters-of-central-european-conifers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/178826.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">58</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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