An Overview of Liquid Biopsy: Non-Invasive Approaches to Monitoring Tumour Condition

<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>An Overview of Liquid Biopsy: Non-Invasive Approaches to Monitoring Tumour Condition</title> <link rel="shortcut icon" href="https://oxfordglobal.com/hubfs/OXFORD_GLOBAL-LOGO_SYMBOL.jpg"> <meta name="description" content="Liquid biopsy methods are increasingly being used to non-invasively monitor tumour state by assessing the condition of ctDNA and cfDNA."> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:description" content="Liquid biopsy methods are increasingly being used to non-invasively monitor tumour state by assessing the condition of ctDNA and cfDNA."> <meta property="og:title" content="An Overview of Liquid Biopsy: Non-Invasive Approaches to Monitoring Tumour Condition"> <meta name="twitter:description" content="Liquid biopsy methods are increasingly being used to non-invasively monitor tumour state by assessing the condition of ctDNA and cfDNA."> <meta name="twitter:title" content="An Overview of Liquid Biopsy: Non-Invasive Approaches to Monitoring Tumour Condition"> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://oxfordglobal.com/hs-fs/hub/8696823/hub_generated/template_assets/135726131582/1732113079147/git/og-stage/css/main.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/fontawesome.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/brands.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/solid.min.css">  <style id="hs_editor_style" type="text/css"> #hs_cos_wrapper_module_17019620504109 { display: block !important; margin-bottom: 0px !important } </style>  <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; if (!window._hsGoogleConsentRunOnce) { window._hsGoogleConsentRunOnce = true; gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); if (useGoogleConsentModeV2) { _hsp.push(['useGoogleConsentModeV2']) } else { _hsp.push(['addPrivacyConsentListener', function(consent){ var hasAnalyticsConsent = consent && (consent.allowed || (consent.categories && consent.categories.analytics)); var hasAdsConsent = consent && (consent.allowed || (consent.categories && consent.categories.advertisement)); gtag('consent', 'update', { 'ad_storage': hasAdsConsent ? 'granted' : 'denied', 'analytics_storage': hasAnalyticsConsent ? 'granted' : 'denied', 'ad_user_data': hasAdsConsent ? 'granted' : 'denied', 'ad_personalization': hasAdsConsent ? 'granted' : 'denied' }); }]); } } gtag('js', new Date()); gtag('set', 'developer_id.dZTQ1Zm', true); gtag('config', 'G-43QK8SYTST'); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-43QK8SYTST"></script>  <link rel="canonical" href="https://oxfordglobal.com/precision-medicine/resources/an-overview-of-liquid-biopsy-non-invasive-approaches-to-monitoring-tumour-condition"> <meta property="og:image" content="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/Liquid-Biopsy-Alternative-Approaches-to-Monitoring-Tumour-Condition.jpg"> <meta name="twitter:image" content="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/Liquid-Biopsy-Alternative-Approaches-to-Monitoring-Tumour-Condition.jpg"> <meta property="og:url" content="https://oxfordglobal.com/precision-medicine/resources/an-overview-of-liquid-biopsy-non-invasive-approaches-to-monitoring-tumour-condition"> <meta name="twitter:card" content="summary"> <meta http-equiv="content-language" content="en"> <meta name="generator" content="HubSpot"></head> <body class="precision-medicine"> <div class="body-wrapper hs-content-id-177607188489 hs-site-page page "> <div data-global-resource-path="git/og-stage/templates/partials/header.html"> <header class="website-header "> <div class="navbar"> <div class="navbar-brands"> <a href="/precision-medicine" class="logo-link current-brand"> <img src="https://oxfordglobal.com/hubfs/Website/Logos/Brand%20Logos/Precision%20Medicine.svg" class="logo-image"> <i class="dropdown fa-solid fa-chevron-down"></i> </a> <div class="brands"> <div class="intro"> <h2> Explore our brands </h2> <div class="desc"> Our brands bring together the industry's most influential leaders and scientific experts, inspiring thought-provoking and insightful content that offers a unique perspective on R&D trends and challenges. </div> </div> <div class="items"> <div class="item primary-brand"> <a href="/" class="logo-link"><img src="https://oxfordglobal.com/hubfs/logo.jpg" class="logo-image"></a> </div> <div class="item active-item"> <a href="/precision-medicine" class="logo-link"><img src="https://oxfordglobal.com/hubfs/Website/Logos/Brand%20Logos/Precision%20Medicine.svg" class="logo-image"></a> </div> <div class="item"> <a href="/discovery-development" class="logo-link"><img src="https://oxfordglobal.com/hubfs/Website/Logos/Brand%20Logos/Discovery%20%26%20Development.svg" class="logo-image"></a> </div> <div class="item"> <a href="/nextgen-biomed" class="logo-link"><img src="https://oxfordglobal.com/hubfs/Website/Logos/Brand%20Logos/NextGen%20Biomed.svg" class="logo-image"></a> </div> </div> </div> </div> <div class="flex flex-align-center navbar-nav"> <a href="#" class="navbar-nav-toggle"> <div class="toggle-icons"> <i class="fa-solid fa-bars toggle-open"></i> <i class="fa-solid fa-xmark toggle-close"></i> </div> </a> <ul class="navbar-nav-items"> <li class="navbar-nav-item"> <a href="#" class="navbar-nav-item-link">Events <i class="fa-solid fa-chevron-down"></i></a> <div class="navbar-subnav"> <div class="subnav-graphics"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Header%20Events.jpg" class="subnav-image"> </div> <div class="subnav-items"> <div class="subnav-item flex-3 divider g-20"> <div class="subnav-item-content bottom-mp-fix"> <h3> In-Person & Online Events </h3> <p>Pivotal moments where high-level industry experts and thought leaders come together for focused knowledge sharing and unparalleled networking opportunities.</p> </div> <div class="subnav-item"> <div class="event-pills"> <a href="/precision-medicine/events/spatial-biology-us-west-coast-2024" class="pill center"> <div class="b">Spatial Biology West Coast 2024</div> <div class="heading-smallcaps"> 04 - 05 Dec 2024 | San Diego, CA </div> </a> <a href="/precision-medicine/events/nextgen-omics-us-2025" class="pill center"> <div class="b">NextGen Omics & Spatial Biology US 2025</div> <div class="heading-smallcaps"> 27 - 28 Mar 2025 | Boston, MA </div> </a> <a href="/precision-medicine/events/biomarkers-precision-medicine-2025" class="pill center"> <div class="b">Biomarkers & Precision Medicine 2025</div> <div class="heading-smallcaps"> 30 Sep - 01 Oct 2025 | London, UK </div> </a> <a href="/precision-medicine/events/biomarkers-precision-medicine-us-2025" class="pill center"> <div class="b">Biomarkers & Precision Medicine US 2025</div> <div class="heading-smallcaps"> Oct 2025 | San Francisco, CA </div> </a> <a href="/precision-medicine/events/nextgen-multi-omics-2025" class="pill center"> <div class="b">NextGen Multi-Omics 2025</div> <div class="heading-smallcaps"> 13 - 14 Nov 2025 | London, UK </div> </a> </div> </div> </div> <div class="subnav-item flex-2"> <div class="subnav-item-content bottom-mp-fix"> <h3> Online Activities </h3> <p>Our Monthly Science Exchanges and Webinars keep you connected to the conversation.</p> </div> <div class="online-activities-list flex flex-column g-10">  <div class="online-activity"> <a href="/precision-medicine/online#Regulatory%20developments%20for%20biomarker%20research" class="cta" target="_blank"> <h3 class="other-resources">13/01/25 - Regulatory developments for biomarker research</h3> </a> </div> <div class="top-divider"></div>  <div class="online-activity"> <a href="/precision-medicine/online#Quantum%20Si%20webinar" class="cta" target="_blank"> <h3 class="other-resources">17/01/25 - Quantum Si webinar</h3> </a> </div> <div class="top-divider"></div>  <div class="online-activity"> <a href="/precision-medicine/online#Sartorius%20Webinar" class="cta" target="_blank"> <h3 class="other-resources">10/04/25 - Sartorius Webinar</h3> </a> </div> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/online" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> All Online Activities</a> </div> </div> </div> </div> </li> <li class="navbar-nav-item"> <a href="#" class="navbar-nav-item-link">Community <i class="fa-solid fa-chevron-down"></i></a> <div class="navbar-subnav"> <div class="subnav-graphics"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Header%20Community.jpg" class="subnav-image"> </div> <div class="subnav-items"> <div class="subnav-item flex flex-1 divider"> <div class="subnav-item-content bottom-mp-fix"> <h3> About </h3> <p>We bring together pioneering minds from the biopharma and research communities, providing a platform for exchanging insights and accelerating the development of targeted therapies that transform patient outcomes</p> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/about" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> More Info</a> </div> </div> <div class="subnav-item flex flex-1 divider"> <div class="subnav-item-content bottom-mp-fix"> <h3> Community </h3> <p>Precision Medicine unites experts across the personalized healthcare landscape, including leaders in genomics, biomarker discovery, pathology, AI, targeted therapies, and data-driven diagnostics</p> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/community" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> More Info</a> </div> </div> <div class="subnav-item flex flex-1 "> <div class="subnav-item-content bottom-mp-fix"> <h3> Media Partners </h3> <p>We work with leading journal publications on reciprocal marketing arrangements.</p> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/media-partners" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> More Info</a> </div> </div> </div> </div> </li> <li class="navbar-nav-item"> <a href="#" class="navbar-nav-item-link">Services <i class="fa-solid fa-chevron-down"></i></a> <div class="navbar-subnav"> <div class="subnav-graphics"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Header%20Services.jpg" class="subnav-image"> </div> <div class="subnav-items"> <div class="subnav-item flex flex-1 divider"> <div class="subnav-item-content bottom-mp-fix"> <h3> In-Person Services </h3> <p>At Oxford Global, our events are designed to connect key life science figures and innovative solution providers, accelerating scientific advancement. Our goal is to create valuable connections and an impactful experience through innovative and collaborative formats.</p> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/in-person-services" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> More Info</a> </div> </div> <div class="subnav-item flex flex-1"> <div class="subnav-item-content bottom-mp-fix"> <h3> Digital Marketing Services </h3> <p>Oxford Global’s products offer a powerful channel to associate your brand with the latest advancements within the industry whilst educating and influencing the industry throughout their buying process.</p> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/digital-marketing-services" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> More Info</a> </div> </div> </div> </div> </li> <li class="navbar-nav-item"> <a href="#" class="navbar-nav-item-link">Resources <i class="fa-solid fa-chevron-down"></i></a> <div class="navbar-subnav"> <div class="subnav-graphics"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Header%20Resources.jpg" class="subnav-image"> </div> <div class="subnav-items"> <div class="subnav-item flex-2 divider"> <div class="subnav-item-content bottom-mp-fix"> <h3> Browse All Resources </h3> <p>The latest in multi-omics, biomarker & imaging research, spanning from discovery & development to diagnostics and precision medicine.</p> </div> <div class="subnav-item-content-more"> <a href="/precision-medicine/resources" class="subnav-item-content-more-link"><i class="fa-solid fa-circle-chevron-right"></i> All Precision Medicine Resources</a> </div> </div> <div class="subnav-item flex-4 divider"> <div class="subnav-item-content bottom-mp-fix"> <h3> Latest Resources </h3> <div class="resources"> <div class="resource"> <div class="resource-cover"> <a href="/precision-medicine/resources/alzheimers-society-continue-5m-blood-biomarker-challenge-for-dementia-blood-tests-on-nhs" class="resource-cover-link"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Precision%20Medicine/Alzheimers%20Society%20Continue%20%C2%A35m%20Blood%20Biomarker%20Challenge%20for%20Dementia%20Blood%20Tests%20on%20NHS.jpg" class="resource-cover-image"> </a> </div> <div class="resource-content"> <h3 class="resource-heading"> <a href="/precision-medicine/resources/alzheimers-society-continue-5m-blood-biomarker-challenge-for-dementia-blood-tests-on-nhs">Alzheimer's Society Continue £5m Blood Biomarker Challenge for Dementia Blood Tests on NHS</a> </h3> <div class="resource-abstract"> <span class="resource-date">14/11/24 - </span> The Blood Biomarker Challenge hopes to ‘revolutionize dementia diagnosis in the UK’ through a collaborative pilot of blood tests in the NHS. </div> </div> </div> <div class="top-divider"></div> <div class="resource"> <div class="other-resources"><a href="/precision-medicine/resources/keck-team-integrate-multi-omics-with-environmental-data-for-precision-environmental-health">13/11/24 - Keck Team Integrate Multi-Omics with Environmental Data for Precision Environmental Health</a></div> </div> <div class="top-divider"></div> <div class="resource"> <div class="other-resources"><a href="/precision-medicine/resources/syn-saa-biomarker-highly-correlated-with-dementia-with-lewy-bodies">31/10/24 - αSyn-SAA Biomarker Highly Correlated with Dementia with Lewy Bodies</a></div> </div> </div> </div> </div> <div class="subnav-item flex-3"> <div class="subnav-item-content bottom-mp-fix"> <h3> Featured Resource </h3> <div class="resources flex flex-column g-5"> <a href="https://oxfordglobal.com/precision-medicine/resources/sponsored/webinar/sapient/a-new-golden-age-for-target-identification"> <div class="sponsor-resource flex-column"> <div class="resource-cover img-fluid"> <div class="sponsor-resource-cover-link"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/Sapient%20Webinar%20Website%20Featured%20Image.jpg" class="sponsor-resource-cover-image"> </div> </div> <div class="resource-content p-15"> <h3 class="resource-heading"> A New Golden Age for Target Identification: Accessing the Novel Druggable Space with Discovery Proteomics </h3> <div class="resource-abstract"> On-demand webinar presented by Mo Jain, MD, PhD, Founder and CEO, Sapient and Jonathan Usuka, PhD, MBA Chief Business Officer, Sapient </div> </div> </div> </a> </div> </div> </div> </div> </div> </li> <li class="navbar-nav-item show-sm hide-md hide-lg hide-xl"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});" class="navbar-nav-item-link">Contact</a> </li> <li class="navbar-nav-item show-sm hide-md hide-lg hide-xl"> <a href="#" class="navbar-nav-item-link">Our Brands <i class="fa-solid fa-chevron-down"></i></a> <div class="navbar-subnav"> <div class="subnav-items"> <h2> Explore our brands </h2> <div class="desc"> Our brands bring together the industry's most influential leaders and scientific experts, inspiring thought-provoking and insightful content that offers a unique perspective on R&D trends and challenges. </div> <div class="subnav-item"> <div class="subnav-item-content"> <a href="/">Oxford Global</a> </div> </div> <div class="subnav-item"> <div class="subnav-item-content"> <a href="/precision-medicine">Precision Medicine</a> </div> </div> <div class="subnav-item"> <div class="subnav-item-content"> <a href="/discovery-development">Discovery & Development</a> </div> </div> <div class="subnav-item"> <div class="subnav-item-content"> <a href="/nextgen-biomed">NextGen Biomed</a> </div> </div> </div> </div> </li> </ul> </div> <div class="flex flex-align-center hide-sm show-md show-lg show-xl"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});" class="navbar-button">Contact</a> </div> </div> </header></div> <main id="main-content"> <div class="resource-single"> <div class="header bg-primary-light"> <div class="container-wrapper"> <div class="wide-container header-container"> <div class="header-content flex-1"> <div class="heading-smallcaps"> DPCR | Industry Spotlights & Insight Articles </div> <h1 class="heading"> An Overview of Liquid Biopsy: Non-Invasive Approaches to Monitoring Tumour Condition </h1> <div class="byline"> Edited by Ben Norris | 24 August 2023 </div> <div class="abstract"> Liquid biopsy allows for the analysis of blood samples for tumour-related materials such as ctDNA and CTCs, aiding in the non-invasive monitoring of tumour progression. </div> </div> <div class="header-graphic flex-1"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/Liquid-Biopsy-Alternative-Approaches-to-Monitoring-Tumour-Condition.jpg" class="header-graphic-image"> </div> </div> </div> </div> <div class="container-wrapper"> <div class="wide-container"> <div class="content"> <div class="content-body text-gap">  <p>Although the phrase ‘liquid biopsy’ has been around for many years, it was only introduced as a diagnostic concept in 2010 for the analysis of circulating tumour cells (CTCs) in the blood of cancer patients.</p>   <p>However, while most advances in understanding of liquid biopsy have come in the past 10-15 years, the first steps towards exploring the potential of cell-free DA for the genetic testing of cancer date back to 1948. </p>   <p>The present-day use of the term has now extended to the analysis of circulating tumour-derived vesicles. </p>   <p>In particular, it involves the analysis of circulating tumour DNA (ctDNA) and cell-free DNA (cfDNA), as well as extracellular vesicles (EVs), cell-free microRNAs (cfmiRNAs), and mRNA. </p>   <p>As single- or double-stranded DNA released by tumour cells into the blood, ctDNA harbours the mutations of its parent tumour, making it a good indicator of tumour progression in diseases such as non-small cell lung cancer.</p>   <figure class="wp-block-image size-full"><img src="https://oxfordglobal.com/wp-content/uploads/2023/08/Circulating-Tumour-DNA.jpg" alt="" class="wp-image-45569"><figcaption class="wp-element-caption"><strong>Figure 1.</strong> A diagram of a blood vessel. Here, ctDNA from a malignant tumour circulates alongside healthy DNA in the bloodstream. </figcaption></figure>   <p></p>   <p>One of the chief advantages of liquid biopsies is their value as a non-invasive alternative to surgical biopsy – they have the potential of revealing the molecular signatures of tumours to aid in the individualisation of treatments.</p>   <p>Although most studies to date have been performed on patients with carcinomas and melanomas, CTCs have also been detected in the peripheral blood of patients with primary brain tumours despite the presence of the blood-brain barrier (BBB).</p>   <p>Liquid biopsy assays are currently being validated for the early detection of cancer, with the aim of reducing cancer-related mortality. </p>   <p>However, the use of liquid biopsy-based detection of the early stages of solid cancers remains a challenge. </p>   <p>New blood-based biomarkers are currently being validated in clinical trials, including miRNAs, exosomes, and tumour-educated platelets.  </p>   <h2 id="h-technologies-for-the-detection-of-ctdna-and-cfdna"><strong>Technologies for the Detection of ctDNA and cfDNA </strong></h2>   <p>Several different approaches exist for the detection of ctDNA and cfDNA in liquid biopsy analysis. Each has their own advantages and disadvantages which may lend themselves to a particular use case. </p>   <p><strong>Droplet Digital Polymerase Chain Reaction (ddPCR)</strong></p>   <p>The detection rate of ddPCR for genomic material can be as low as 0.01 to 0.1%, and the approach is useful for identifying potentially rare mutations, as well as calculating copy number variants. However, it can only be used to evaluate the presence of characterised sequences. </p>   <p><strong>Beads, Emulsion, Amplification, and Magnetics (BEAMing)</strong></p>   <p>Similarly to ddPCR, BEAMing is a relatively sensitive and inexpensive method of screening for known mutations. It combines PCR with flow cytometry, and can detect alterations in genomic material at concentrations as low as 0.01%, with excellent concordance to tissue testing. </p>   <p><strong>Cancer Personalised Profiling by Deep Sequencing (CAPP-Seq) </strong></p>   <p>CAPP-Seq identifies alterations in ctDNA and cfDNA by utilising large genomic libraries and individual patient sample sequence signatures. It can identify major mutation types such as insertions and copy variants, but it cannot identify fusions. </p>   <p><strong>Tagged Amplicon Deep Sequencing (TAm-Seq)</strong></p>   <p>TAm-Seq allows for a very specific and sensitive analysis of approximately 97% and can detect DNA levels as low as 2% by using primers to tag and identify genomic sequences. It has a high sequencing flux, a reduced sequencing time and cost, and can simultaneously sequence millions of DNA molecules. </p>   <p><strong>Whole Exome Sequencing (WES)</strong></p>   <p>Whole exome sequencing provides characterisation and analysis of all present tumour mutations, meaning it can be used to identify potential oncogenes and tumour suppressor genes. However, its sensitivity may be lower than other methods as it includes exomic alterations.   </p>   <p><strong>Whole Genome Sequencing (WGS) </strong></p>   <p>Whole genome sequencing evaluates the entire tumour genome to determine characterised and deleterious alterations, along with variants of unknown significance. It has great potential for a comprehensive evaluation of all tumour mutations, but is limited by quality assurance, ethical issues, time, and cost. </p>   <p><strong>Whole Genome Bisulfite Sequencing (WGBS-Seq)</strong></p>   <p>WGBS-Seq is the gold standard in DNA methylation analysis: it provides a single cytosine measurement and has a high degree of accuracy. While it can discover partially methylated domains in cancer cells, DNA must exist in varying degrees of degradation. As such, this method may have reduced sensitivity. </p>   <h2><strong>How do Liquid Biopsies Supplement Diagnostic Approaches?</strong></h2>   <p>Solid biopsies are still the gold standard for tumour diagnosis, but they only represent a static and spatially constrained representation of tumour condition from the time of surgery. </p>   <p>Liquid biopsy approaches offer a more holistic assessment of tumour condition and state, allowing for continuous monitoring of cancer state and spread. </p>   <ul> <li><a href="https://oxfordglobal.com/resources/dpcr-market-trends-and-predictions-for-future-development/" target="_blank" rel="noreferrer noopener">dPCR Market Trends and Predictions for Future Development</a></li>   <li><a href="https://oxfordglobal.com/resources/ddpcr-exploring-the-progress-of-pcr-technology-and-novel-applications/" target="_blank" rel="noreferrer noopener">Exploring the Progress of PCR Technology and Novel Applications</a></li>   <li><a href="https://oxfordglobal.com/resources/microfluidic-droplet-based-pcr-a-tool-to-solve-challenges-in-personalised-medicine-and-cancer-detection/" target="_blank" rel="noreferrer noopener">Solving Challenges in Cancer Detection Using Droplet-Based PCR</a></li> </ul>   <p></p>   <p>Liquid biopsies also avoid significant clinical risks such as wounding or infection that accompany solid tumour biopsies, which can be a particular concern for immunosuppressed patients.</p>   <p>While liquid biopsy is unlikely to fully replace or directly compete with solid biopsy as a diagnostic approach in the near future, some predict that liquid biopsy will be fully integrated alongside solid biopsies in the clinic in the next five years. </p>   <p><em>Get your weekly dose of industry news and announcements </em><a href="https://oxfordglobal.com/omics/news/" target="_blank" rel="noreferrer noopener"><em>here</em></a><em>, or head over to our </em><a href="https://oxfordglobal.com/omics/" target="_blank" rel="noreferrer noopener"><em>Omics portal</em></a><em> to catch up with the latest advances in tumour analysis. To learn more about our upcoming NextGen Omics UK conference in London, </em><a href="https://oxfordglobal.com/nextgen-omics-series-uk/" target="_blank" rel="noreferrer noopener"><em>click here</em></a><em> to download an agenda or register your interest.</em> </p>  <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-event"> <h3 class="center">Related Events</h3> For more on this topic, you may be interested in our upcoming <a href="/precision-medicine/events/nextgen-multi-omics-2025">7th Annual Digital PCR Congress</a> </div> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/precision-medicine/resources/liquid-biopsy-solutions-for-circulating-tumor-cell-and-rare-cell-analysis"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/Welcome-to-the-RNAscope-Experience-1.jpg" class="cover-graphic-image"> </div> </a><div class="content"><a href="/precision-medicine/resources/liquid-biopsy-solutions-for-circulating-tumor-cell-and-rare-cell-analysis"> <h4> Liquid Biopsy Solutions for Circulating Tumor Cell and Rare Cell Analysis </h4> <div class="abstract"> </div> <div class="read-more"> <a href="/precision-medicine/resources/liquid-biopsy-solutions-for-circulating-tumor-cell-and-rare-cell-analysis" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/precision-medicine/resources/dpcr-market-trends-and-predictions-for-future-development"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/dPCR-Market-Trends-and-Predictions-for-2032.jpg" class="cover-graphic-image"> </div> </a><div class="content"><a href="/precision-medicine/resources/dpcr-market-trends-and-predictions-for-future-development"> <h4> dPCR Market Trends and Predictions for Future Development </h4> <div class="abstract"> The applications and opportunities offered by digital polymerase chain reaction (dPCR) technology have provided new techniques for molecular diagnostics. With an estimated global market value of USD $1bn by 2032, the future looks promising for dPCR approaches. </div> <div class="read-more"> <a href="/precision-medicine/resources/dpcr-market-trends-and-predictions-for-future-development" class="read-more-link">Read More</a> </div></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things Precision Medicine </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177053686110">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery & Development</a> </li> <li> <a href="/nextgen-biomed/">NextGen Biomed</a> </li> </ul> </div> <div class="footer-column"> <h3>Services</h3> <ul> <li> <a href="https://oxfordglobal.com/in-person-services/"> In-Person Services </a> </li> <li> <a href="https://oxfordglobal.com/digital-marketing-services/"> Digital Marketing Services </a> </li> </ul> <h3>Upcoming Events</h3> <ul> <li> <a href="https://oxfordglobal.com/calendar/"> Event Calendar </a> </li> </ul> </div> <div class="footer-column"> <h3>Company</h3> <ul> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/about-us/"> About </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/vacancies/"> Vacancies </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/csr-policy/"> CSR Policy </a> </li> <li class="elementor-icon-list-item"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});"> Contact </a> </li> </ul> </div> <div class="footer-column"> <p> <a href="tel:+441865248455">+44 1865 248 455</a><br> <a href="mailto:help@oxfordglobal.com">help@oxfordglobal.com</a> </p> <p> <strong>Our UK Address:</strong><br> Godstow Court<br> Minns Business Park<br> Botley<br> Oxford, OX2 0JB </p> <p> <strong>Our US Address:</strong><br> 100 Cambridge Street<br> 14th Floor<br> Boston<br> MA 02114 </p> </div> </div> <div class="footer-bottom grid g-20"> <div class="span8 span12-sm span12-md flex flex-column g-10"> <div class="copyright"> © Oxford Global Marketing Ltd. All rights reserved. </div> <ul class="legal-links flex flex-row g-30 flex-column-sm g-sm-10"> <li><a href="https://oxfordglobal.com/legal/">Terms & Conditions</a></li> <li><a href="https://oxfordglobal.com/legal/privacy-policy/">Privacy Policy</a></li> <li><a href="https://oxfordglobal.com/legal/website-terms/">Cookies</a></li> <li><a href="https://www.wishagency.co.uk/" target="_BLANK">Digital Agency Wish</a></li> </ul> </div> <div class="span4 span12-sm span12-md flex-align-end"> <ul class="social-links flex flex-row flex-justify-end flex-justify-center-sm flex-justify-center-md g-30"> <li><a href="https://www.facebook.com/OGConferences/" target="_BLANK"><i class="fa-brands fa-square-facebook"></i></a></li> <li><a href="https://www.linkedin.com/company/oxford-global/" target="_BLANK"><i class="fa-brands fa-linkedin"></i></a></li> <li><a href="https://twitter.com/OGConferences" target="_BLANK"><i class="fa-brands fa-square-x-twitter"></i></a></li> </ul> </div> </div> </footer></div> </div> <script src="/hs/hsstatic/jquery-libs/static-1.1/jquery/jquery-1.7.1.js"></script> <script>hsjQuery = window['jQuery'];</script>  <script defer src="/hs/hsstatic/content-cwv-embed/static-1.1293/embed.js"></script> <script src="https://oxfordglobal.com/hs-fs/hub/8696823/hub_generated/template_assets/182600797781/1731148644227/git/og-stage/js/inlineSVG.min.js"></script> <script src="https://oxfordglobal.com/hs-fs/hub/8696823/hub_generated/template_assets/135724366742/1725380923802/git/og-stage/js/main.min.js"></script> <script> function getVideoId(url) { var regExp = /^.*(youtu.be\/|v\/|u\/\w\/|embed\/|watch\?v=|\&v=)([^#\&\?]*).*/; var match = url.match(regExp); if (match && match[2].length == 11) { return match[2]; } else { return false; } } function getVideoEmbed(id) { return '<iframe src="https://www.youtube.com/embed/' + id + '" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen style="aspect-ratio: 16 / 9; width: 100%;"></iframe>'; } jQuery("div.content-body .wp-block-embed__wrapper:contains('youtu')").each(function() { var yt_url = $(this).html().trim(); var yt_id = getVideoId(yt_url); var yt_embed = getVideoEmbed(yt_id); $(this).html(yt_embed); }); </script>  <script type="text/javascript"> var _hsq = _hsq || []; _hsq.push(["setContentType", "standard-page"]); _hsq.push(["setCanonicalUrl", "https:\/\/oxfordglobal.com\/precision-medicine\/resources\/an-overview-of-liquid-biopsy-non-invasive-approaches-to-monitoring-tumour-condition"]); _hsq.push(["setPageId", "hubdb-177607188489-94056879-181737540741"]); _hsq.push(["setContentMetadata", { "contentPageId": "hubdb-177607188489-94056879-181737540741", "legacyPageId": "hubdb-177607188489-94056879-181737540741", "contentFolderId": null, "contentGroupId": null, "abTestId": null, "languageVariantId": 177607188489, "languageCode": "en", }]); </script> <script type="text/javascript" id="hs-script-loader" async defer src="/hs/scriptloader/8696823.js"></script>  <script type="text/javascript"> var hsVars = { render_id: "967e78ed-d57c-41d0-b2d7-409ebb9eeb50", ticks: 1732669153319, page_id: 177607188489, dynamic_page_id: "hubdb-177607188489-94056879-181737540741", content_group_id: 0, portal_id: 8696823, app_hs_base_url: "https://app.hubspot.com", cp_hs_base_url: "https://cp.hubspot.com", language: "en", analytics_page_type: "standard-page", scp_content_type: "", analytics_page_id: "hubdb-177607188489-94056879-181737540741", category_id: 1, folder_id: 0, is_hubspot_user: false } </script> <script defer src="/hs/hsstatic/HubspotToolsMenu/static-1.354/js/index.js"></script> </body></html>

CINXE.COM

An Overview of Liquid Biopsy: Non-Invasive Approaches to Monitoring Tumour Condition