Search results for: forskolin

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forskolin</title> <meta name="description" content="Search results for: forskolin"> <meta name="keywords" content="forskolin"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="forskolin"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: forskolin</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Simultaneous Production of Forskolin and Rosmarinic Acid in vitro Cultures of Coleus Forskohlii Briq</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ennus%20Tajuddin%20Tamboli">Ennus Tajuddin Tamboli</a>, <a href="https://publications.waset.org/abstracts/search?q=Madhukar%20Garg"> Madhukar Garg</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohd.%20Mujeeb"> Mohd. Mujeeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Sayeed%20Ahmad"> Sayeed Ahmad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An efficient protocol for simultaneous production of forskolin and rosmarinic acid in in vitro callus derived from the leaves of Coleus forskohlii Briq. has been developed. MS media was used for the establishment of cultures and NAA + 6-BA (1.0 ppm) was found best for callus growth. The callus was further subjected to treatment with various elicitor/precursors viz. chitosan, thidiazuron and methyl jasmonate to observe their effect on production of biomass and accumulation of secondary metabolites. The content of forskolin and rosmarinic acid were estimated by HPTLC, in comparison to natural explant which showed 2 fold and 10 fold rise in forskolin and rosmarinic acid content, respectively. Methy1 jasmonate 50 µM was found best for production of forskolin, whereas thidiazuron showed best results in the yield of rosmarinic acid, separately in static culture. However, combined treatment in suspension culture showed moderated effect for increase in secondary metabolites but the biomass increased significantly as compared to static culture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=plant%20tissue%20culture" title="plant tissue culture">plant tissue culture</a>, <a href="https://publications.waset.org/abstracts/search?q=secondary%20metabolites" title=" secondary metabolites"> secondary metabolites</a>, <a href="https://publications.waset.org/abstracts/search?q=coleus" title=" coleus"> coleus</a>, <a href="https://publications.waset.org/abstracts/search?q=forskolin" title=" forskolin"> forskolin</a>, <a href="https://publications.waset.org/abstracts/search?q=rosmarinic%20acid" title=" rosmarinic acid"> rosmarinic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=HPTLC" title=" HPTLC"> HPTLC</a> </p> <a href="https://publications.waset.org/abstracts/1357/simultaneous-production-of-forskolin-and-rosmarinic-acid-in-vitro-cultures-of-coleus-forskohlii-briq" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1357.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">343</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Chronic Hypertension, Aquaporin and Hydraulic Conductivity: A Perspective on Pathological Connections</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chirag%20Raval">Chirag Raval</a>, <a href="https://publications.waset.org/abstracts/search?q=Jimmy%20Toussaint"> Jimmy Toussaint</a>, <a href="https://publications.waset.org/abstracts/search?q=Tieuvi%20Nguyen"> Tieuvi Nguyen</a>, <a href="https://publications.waset.org/abstracts/search?q=Hadi%20Fadaifard"> Hadi Fadaifard</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Wolberg"> George Wolberg</a>, <a href="https://publications.waset.org/abstracts/search?q=Steven%20Quarfordt"> Steven Quarfordt</a>, <a href="https://publications.waset.org/abstracts/search?q=Kung-ming%20Jan"> Kung-ming Jan</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20S.%20Rumschitzki"> David S. Rumschitzki</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Numerous studies examine aquaporins’ role in osmotic water transport in various systems but virtually none focus on aquaporins’ role in hydrostatically-driven water transport involving mammalian cells save for our laboratory’s recent study of aortic endothelial cells. Here we investigate aquaporin-1 expression and function in the aortic endothelium in two high-renin rat models of hypertension, the spontaneously hypertensive genomically altered Wystar-Kyoto rat variant and Sprague-Dawley rats made hypertensive by two kidney, one clip Goldblatt surgery. We measured aquaporin-1 expression in aortic endothelial cells from whole rat aortas by quantitative immunohistochemistry, and function by measuring the pressure driven hydraulic conductivities of excised rat aortas with both intact and denuded endothelia on the same vessel. We use them to calculate the effective intimal hydraulic conductivity, which is a combination of endothelial and subendothelial components. We observed well-correlated enhancements in aquaporin-1 expression and function in both hypertensive rat models as well as in aortas from normotensive rats whose expression was upregulated by 2h forskolin treatment. Upregulated aquaporin-1 expression and function may be a response to hypertension that critically determines conduit artery vessel wall viability and long-term susceptibility to atherosclerosis. Numerous studies examine aquaporins’ role in osmotic water transport in various systems but virtually none focus on aquaporins’ role in hydrostatically-driven water transport involving mammalian cells save for our laboratory’s recent study of aortic endothelial cells. Here we investigate aquaporin-1 expression and function in the aortic endothelium in two high-renin rat models of hypertension, the spontaneously hypertensive genomically altered Wystar-Kyoto rat variant and Sprague-Dawley rats made hypertensive by two kidney, one clip Goldblatt surgery. We measured aquaporin-1 expression in aortic endothelial cells from whole rat aortas by quantitative immunohistochemistry, and function by measuring the pressure driven hydraulic conductivities of excised rat aortas with both intact and denuded endothelia on the same vessel. We use them to calculate the effective intimal hydraulic conductivity, which is a combination of endothelial and subendothelial components. We observed well-correlated enhancements in aquaporin-1 expression and function in both hypertensive rat models as well as in aortas from normotensive rats whose expression was upregulated by 2h forskolin treatment. Upregulated aquaporin-1 expression and function may be a response to hypertension that critically determines conduit artery vessel wall viability and long-term susceptibility to atherosclerosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20hypertension" title="acute hypertension">acute hypertension</a>, <a href="https://publications.waset.org/abstracts/search?q=aquaporin-1" title=" aquaporin-1"> aquaporin-1</a>, <a href="https://publications.waset.org/abstracts/search?q=hydraulic%20conductivity" title=" hydraulic conductivity"> hydraulic conductivity</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrostatic%20pressure" title=" hydrostatic pressure"> hydrostatic pressure</a>, <a href="https://publications.waset.org/abstracts/search?q=aortic%20endothelial%20cells" title=" aortic endothelial cells"> aortic endothelial cells</a>, <a href="https://publications.waset.org/abstracts/search?q=transcellular%20flow" title=" transcellular flow"> transcellular flow</a> </p> <a href="https://publications.waset.org/abstracts/39927/chronic-hypertension-aquaporin-and-hydraulic-conductivity-a-perspective-on-pathological-connections" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39927.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">232</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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Search results for: forskolin