Recombinant Human IL-15 GMP Protein, CF (BT-015-GMP) by R&D Systems, Part of Bio-Techne

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Reproducible results in bioactivity assays." /> <script type="application/ld+json" id="json-ld">[{"@context":"http://schema.org","@type":"Product","additionalProperty":[{"additionalProperty":{"@type":"PropertyValue","name":"Applications","value":"Bioactivity"}},{"additionalProperty":{"@type":"PropertyValue","name":"Accession #","value":"P40933.1"}},{"additionalProperty":{"@type":"PropertyValue","name":"Source","value":"E. coli"}}],"aggregateRating":[],"alternateName":"","brand":{"@type":"Brand","name":"R&D Systems"},"description":"Recombinant Human IL-15 GMP Protein, CF","image":[{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-bioactivity-1912022161323.jpg","description":"GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED50for this effect is 0.300-2.60 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-15."},{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg","description":"2 \u03bcg/lane of GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a single band at 9 kDa."},{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg","description":"Two samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the human IL-15 Quantikine ELISA (D1500) standard curve (black circles) using 4PL regression analysis. The human IL-15 Quantikine ELISA has an assay range of 3.9-250 pg/mL."},{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg","description":"Thirteen samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the Simple Plex Human IL-15 cartridge (SPCKB-PS-000500) standard curve (black circles) using 4PL logistic regression analysis. The Simple Plex IL-15 cartridge has an assay range of 0.2-1,950 pg/mL."},{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-248202392734..jpg","description":"Charge consistency of GMP Human IL-15 Protein"},{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-24820239328..jpg","description":"Purity consistency of GMP Human IL-15 Protein"}],"isRelatedTo":[{"@type":"Product","brand":{"@type":"Brand","name":"R&D Systems"},"description":"Recombinant Human IL-15 Protein, Animal-Free","image":[{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-afl_recombinant-human-il-15-protein-animal-free-cell-proliferation-1692021135243.jpg","description":"Animal-FreeTM Recombinant Human IL-15 (Catalog # BT-015-AFL) stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED50for this effect is 0.300-2.60 ng/mL. Two independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of Animal-Free IL-15."},{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/bt-015-afl_recombinant-human-il-15-protein-animal-free-sds-page-810202112312.jpg","description":"2 \u03bcg/lane of Recombinant Human IL-15 Protein, Animal-Free (Catalog # BT-015-AFL) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 9 kDa."}],"mpn":"BT-015-AFL","name":"Recombinant Human IL-15 Protein, Animal-Free","sku":"BT-015-AFL","url":"https://www.bio-techne.com/p/proteins-enzymes/recombinant-human-il-15-protein-animal-free_bt-015-afl"}],"itemcondition":"new","mpn":"BT-015-GMP","name":"Recombinant Human IL-15 GMP Protein, 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class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/applications/immuno-oncology-clinical" class="dropdown-item text-wrap" 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Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/custom-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1891">All Custom Services</a> <a href="/services/custom-antibody-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/906">Custom Antibody Services</a> <a href="/services/custom-cell-and-gene-therapy-services" class="dropdown-item text-wrap" 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href="/services/instrument-services/simple-western-service-plans" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3181">Simple Western Service Plans</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Licensing<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/biotechnology-licensing-partnering" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1101">Biotechnology Licensing and Partnering</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup 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data-time_datapoints="-0.40004897117615" data-time_template="0.40004897117615" data-time_post_epcc="0.92723393440247" data-time_epcc="-0.40004897117615" data-render_time="Wednesday 20th of November 2024 07:40:20 AM" data-fallback="FALSE" data-time_to_process_data="0.11111402511597" class="px-4 container" class="container"> <div id="above-fold-section"> <div class="mb-2 o__product-summary"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Recombinant Human IL-15 GMP Protein, CF <span id="gmp-icon"> <span class="a___badge-gmp badge text-white align-middle p-1" title="GMP Product">GMP</span> </span> <span class="rounded align-middle p-1 badge best-seller" title="Best Seller">Best Seller</span> </h1> <h2 class="font-weight-normal h4"> R&D Systems, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">BT-015-GMP</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div id="submit_review_wrapper" class="col-auto d-flex align-self-center"> <div id="submit_review"> <a href="/reviews/BT-015-GMP" class="submit_review" rel="nofollow"> <span class="icon-plus-circle d-none d-lg-inline pr-1"></span> Submit a review </a> </div> </div> <div class="col-auto d-flex align-self-center"> <div> <div class="px-0 my-1" id="datasheet-summary-wrapper" data-section="section-base--top-jumplink"> <article class="top-jumplink-wrapper"> <span class="icon-icon-pdf text-error-red"></span> <a href="#product-documents" class="product-documents-top-link" rel="nofollow">Product Datasheet / COA / SDS</a> </article> </div> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Animal-Free </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" alt="R&D Systems, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> <div class="row border-top mb-2" id="images-orderdetail-wrapper"> <div class="col-xl-6 mt-2" id="images-wrapper" data-section="image_summary"> <div id="image-tree" data-section="component-product-image-tree" class="vertical lightbox" data-mdb-zoom-effect="true"> <div id="product-image-gallery" class="row"> <div class="col-md-2 d-none d-md-block"> <ul class="list-inline m-0"> <li data-id="1" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg" alt="" title="Recombinant Human IL-15 GMP Protein SDS-PAGE" data-caption="2 μg/lane of GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a single band at 9 kDa." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg" data-id="0" data-application="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg" class="lazy" /> </div> </li> <li data-id="2" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg" alt="" title="Recombinant Human IL-15 GMP Protein Measured by Quantikine ELISA." data-caption="Two samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the human IL-15 Quantikine ELISA (<a href="/p/elisa-kits/human-il-15-quantikine-elisa-kit_d1500" target="_self">D1500</a>) standard curve (black circles) using 4PL regression analysis. The human IL-15 Quantikine ELISA has an assay range of 3.9-250 pg/mL." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg" data-id="1" data-application="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg" class="lazy" /> </div> </li> <li data-id="3" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg" alt="" title="Recombinant Human IL-15 GMP Protein Measured by ELLA." data-caption="Thirteen samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the Simple Plex Human IL-15 cartridge (<a href="/p/simple-plex/simple-plex-human-il-15-cartridge_spckb-ps-000500" target="_self">SPCKB-PS-000500</a>) standard curve (black circles) using 4PL logistic regression analysis. The Simple Plex IL-15 cartridge has an assay range of 0.2-1,950 pg/mL." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg" data-id="2" data-application="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg" class="lazy" /> </div> </li> <li data-id="4" class="none"> <i data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-248202392734..jpg" data-alt="Charge consistency of GMP Human IL-15 Protein" title="Recombinant Human IL-15 GMP Protein Purity Analysis by Charge Variation." data-caption="Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice icIEF using native fluorescence detection (Mkr 5.85 and 9.99 are pI Markers). Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges="" data-application="Data" class="none"></i> </li> <li data-id="5" class="none"> <i data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-24820239328..jpg" data-alt="Purity consistency of GMP Human IL-15 Protein" title="Recombinant Human IL-15 GMP Protein Purity Analysis by Size Separation." data-caption="Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges="" data-application="Data" class="none"></i> </li> <li class="list-inline-item"> <div class="image-slider-container"> <div class="lightbox product-image-lightbox"> <div class="lightbox border text-bt-dark-blue text-center search_result_thumbnail_image bg-light-gray rounded" style="padding: 20px 10px" title="Recombinant Human IL-15 GMP Protein Purity Analysis by Size Separation." data-caption="Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-24820239328..jpg" data-id="3" data-application="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-24820239328..jpg"> +2 <br>images </div> </div> </div> </li> </ul> </div> <div class="col-md-10 border rounded d-flex align-items-center justify-content-center product-image-lightbox"> <div class="text-center my-2" data-brand="rnd"> <img src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-bioactivity-1912022161323.jpg" alt="" title="Recombinant Human IL-15 Protein GMP Bioactivity." data-caption="GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED<sub>50</sub>for this effect is 0.300-2.60 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-15." data-badges='' data-id="0" width="250" height="250" fetchpriority="high" as="image" class="search_result_thumbnail_image active" /> </div> </div> </div> </div> </div> <div class="col-xl-6 mt-2" id="orderdetails-wrapper" data-section="order_detail_block"> <div class="alert_content" class=".alert .alert-success" > <div class="alert alert-success p-2" role="alert"> <div class="d-inline-flex p-1"> <div class="pr-2"> <span class="icon-note-important"></span> </div> <div> <p>New! Bypass reconstitution steps by using a liquid formulation of GMP-grade Recombinant Human IL-15. Find out more <a href="https://www.bio-techne.com/reagents/proteins/liquid-cytokines-workflow">here</a>.</p> </div> </div> </div> </div> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" data-lq="1" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="BT-015-GMP"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-3 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div class="atc-show-hide"> <div class="atc-show-hide"> <div class="col-12 py-2 font-weight-bold px-0"> Single Use Lyophilized Vial <a href="#" data-toggle="tooltip" title="Our single use 10 µg fill process size vials optimized for a 1L T Cell culture process."> <span class="icon-information-outline2 ml-1"></span> </a> </div> <div id="ProductCart-sample" class="atc-lines type-sample"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="BT-015-GMP-010" data-hidden="false"> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">BT-015-GMP-010</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> </div> <hr/> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-3 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="atc-show-hide"> <div class="col-12 py-2 font-weight-bold px-0"> Lyophilized <a href="#" data-toggle="tooltip" title="See below for reconstitution information"> <span class="icon-information-outline2 ml-1"></span> </a> </div> <div id="ProductCart-cf" class="atc-lines type-cf"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="BT-015-GMP-01M" data-hidden="false"> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">BT-015-GMP-01M</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="BT-015-GMP-025" data-hidden="false"> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">BT-015-GMP-025</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> </div> <hr/> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-3 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-4 col-md-3 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Product Details</h3> <div class="row mt-5"> <div class="col-sm-12"> <ul> <li>Single use vials supplement 1L of T Cell Media (Cat # <a href="https://www.bio-techne.com/p/cell-culture/gmp-human-t-cell-media_ccm038-gmp">CCM038-GMP</a>) to support T Cell Cultures in a  G-Rex 100M bioreactor</li> <li>Liquid formulation minimizes reconstitution steps</li> <li>Lot-to-lot consistency</li> <li>Stringent guidelines for patient safety</li> <li>Scalability necessary to support successful therapeutics</li> <li>Learn more about manufacturing in <a href="https://www.bio-techne.com/gmp-manufacturing-facility" target="_blank">our new GMP facility</a></li> <li>Test it in your process! <a href="https://www.bio-techne.com/gmp-products/gmp-proteins/sample-gmp-proteins">Request a sample of GMP IL-15</a></li> </ul> </div> </div> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> E. coli </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Accession #</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <a href="https://www.ncbi.nlm.nih.gov/protein/P40933.1" class="a___link-external" target="_blank" rel="nofollow">P40933.1</a> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Conjugate</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Unconjugated </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Applications</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Bioactivity </div> </div> </div> <div class="container"> <div class="row product-data"> <div class="col-lg-6 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4><a href="/t/il-15/proteins-enzymes">View all IL-15 Proteins and Enzymes »</a></h4> </div> </div> </div> </div> <div class="border-top border-bottom recommended-products-section" id="recommendation-viewed" data-product_code="BT-015-GMP" data-type=viewed></div> <div id="product-specifications" class="bt-pp-border-bottom py-5" data-section="section-base--product-specifications"> <h3>Product Specifications</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <em>E. coli</em>-derived human IL-15 protein<br>Asn49-Ser162<br>Produced using non-animal reagents in an animal-free laboratory. <br>Manufactured and tested under cGMP guidelines. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Purity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> >97%, by SDS-PAGE with quantitative densitometry by Coomassie® Blue Staining. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Endotoxin Level</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.10 EU per 1 μg of the protein by the LAL method. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>N-terminal Sequence Analysis</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Asn49-Trp-Val-Asn-Val-Ile-Ser-Asp-Leu-Lys </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Predicted Molecular Mass</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 13 kDa </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>SDS-PAGE</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 9 kDa, under reducing conditions </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Activity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.<br />The ED<sub>50</sub> for this effect is 0.300-2.60 ng/mL. The specific activity of recombinant human IL-15 is >2.00 x 10<sup>8</sup> units/mg, which is calibrated against the human IL-15 reference standard (NIBSC code: 95/554). </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host Cell Protein</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <1.00 ng per μg of protein when tested by ELISA. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Mycoplasma</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Negative for Mycoplasma. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host Cell DNA</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.0100 ng per µg of protein when tested by PCR. </div> </div> </div> </div> <div id="scientific-data" class="bt-pp-border-bottom py-5" data-anchor-label="Scientific Data" data-section="section-base--scientific-data"> <div> <h3>Scientific Data Images for Recombinant Human IL-15 GMP Protein, CF </h3> </div> <div class="product-data-wrapper mt-5" id="scientific-data-table" data-scientific-count="3"> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-bioactivity-1912022161323.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-bioactivity-1912022161323.jpg" alt="" title="Recombinant Human IL-15 Protein GMP Bioactivity." data-caption="GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED<sub>50</sub>for this effect is 0.300-2.60 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-15." data-badges="" data-application="Bioactivity" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-15 Protein GMP Bioactivity.</h4> GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED<sub>50</sub>for this effect is 0.300-2.60 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-15. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-sds-page-7102021122222.jpg" alt="" title="Recombinant Human IL-15 GMP Protein SDS-PAGE" data-caption="2 μg/lane of GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a single band at 9 kDa." data-badges="" data-application="SDS-Page" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-15 GMP Protein SDS-PAGE</h4> 2 μg/lane of GMP-grade Recombinant Human IL-15 (Catalog # BT-015-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a single band at 9 kDa. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023155817.jpg" alt="" title="Recombinant Human IL-15 GMP Protein Measured by Quantikine ELISA." data-caption="Two samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the human IL-15 Quantikine ELISA (<a href="/p/elisa-kits/human-il-15-quantikine-elisa-kit_d1500" target="_self">D1500</a>) standard curve (black circles) using 4PL regression analysis. The human IL-15 Quantikine ELISA has an assay range of 3.9-250 pg/mL." data-badges="" data-application="ELISA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-15 GMP Protein Measured by Quantikine ELISA.</h4> Two samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the human IL-15 Quantikine ELISA (<a href="/p/elisa-kits/human-il-15-quantikine-elisa-kit_d1500" target="_self">D1500</a>) standard curve (black circles) using 4PL regression analysis. The human IL-15 Quantikine ELISA has an assay range of 3.9-250 pg/mL. </div> </div> </div> <span class="product-data-wrapper table" id="more-scientific-data" style="display:none"> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-elisa-1442023161029.jpg" alt="" title="Recombinant Human IL-15 GMP Protein Measured by ELLA." data-caption="Thirteen samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the Simple Plex Human IL-15 cartridge (<a href="/p/simple-plex/simple-plex-human-il-15-cartridge_spckb-ps-000500" target="_self">SPCKB-PS-000500</a>) standard curve (black circles) using 4PL logistic regression analysis. The Simple Plex IL-15 cartridge has an assay range of 0.2-1,950 pg/mL." data-badges="" data-application="ELISA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-15 GMP Protein Measured by ELLA.</h4> Thirteen samples of GMP-grade human IL-15 (Catalog number BT-015-GMP, green circles) were interpolated with the Simple Plex Human IL-15 cartridge (<a href="/p/simple-plex/simple-plex-human-il-15-cartridge_spckb-ps-000500" target="_self">SPCKB-PS-000500</a>) standard curve (black circles) using 4PL logistic regression analysis. The Simple Plex IL-15 cartridge has an assay range of 0.2-1,950 pg/mL. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-248202392734..jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-248202392734..jpg" alt="Charge consistency of GMP Human IL-15 Protein" title="Recombinant Human IL-15 GMP Protein Purity Analysis by Charge Variation." data-caption="Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice icIEF using native fluorescence detection (Mkr 5.85 and 9.99 are pI Markers). Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges="" data-application="Data" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-15 GMP Protein Purity Analysis by Charge Variation.</h4> Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice icIEF using native fluorescence detection (Mkr 5.85 and 9.99 are pI Markers). Profiles from the three runs were superimposed, showing excellent manufacturing consistency. </div> </div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-24820239328..jpg" data-srcset="https://resources.bio-techne.com/images/products/bt-015-gmp_recombinant-human-il-15-gmp-protein-cf-data-24820239328..jpg" alt="Purity consistency of GMP Human IL-15 Protein" title="Recombinant Human IL-15 GMP Protein Purity Analysis by Size Separation." data-caption="Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges="" data-application="Data" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-15 GMP Protein Purity Analysis by Size Separation.</h4> Three independent lots of Recombinant Human IL-15 GMP Protein (Catalog # BT-015-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency. </div> </div> </span> <div class="row"> <div class="col-md-2"> <a id="scientific-view-more" class="more"> View 3 more images </a> </div> </div> </div> </div> <div id="preparation--storage" class="bt-pp-border-bottom py-5" data-section="section-protein--preparation-storage"> <h3>Formulation, Preparation and Storage</h3> <div class="datasheet_section"> <div class="row "> <div class="col-xs-12 col-md-6 "> <div class="border-left border-right border-top text-center"> <h5 class="m-0 p-3 bg-dark-bt-blue text-white"> Lyophilized: BT-015-GMP </h5> </div> <table class="ds_table_html table-bordered tablesaw tablesaw-stack"> <tbody> <tr> <td class="font-weight-bold">Formulation</td> <td class="w-50">Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.</td> </tr> <tr> <td class="font-weight-bold">Reconstitution</td> <td class="w-50">Reconstitute at 100-500 μg/mL in PBS.</td> </tr> <tr> <td class="font-weight-bold">Shipping</td> <td class="w-50">The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="font-weight-bold">Stability & Storage</td> <td class="w-50"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>A minimum of 12 months when stored at ≤ -20 °C as supplied. Refer to lot specific COA for the Use by Date. </LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>3 months, ≤ -20 °C under sterile conditions after reconstitution.</LI></UL></td> </tr> </tbody> </table> </div> <div class="col-xs-12 col-md-6"> <div class="border-left border-right border-top text-center"> <h5 class="m-0 p-3 bg-dark-bt-blue text-white">Liquid: BT-015-GMP/LQ</h5> </div> <table class="ds_table_html table-bordered tablesaw tablesaw-stack"> <tbody> <tr> <td class="font-weight-bold">Formulation</td> <td class="w-50">Supplied as a 0.2 μm filtered solution in PBS.</td> </tr> <tr> <td class="font-weight-bold">Shipping</td> <td class="w-50">The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="font-weight-bold">Stability & Storage</td> <td class="w-50"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>A minimum of 6 months when stored at ≤ -65 °C as supplied. Refer to lot specific COA for the Use by Date. </LI><LI>1 month, 2 to 8 °C under sterile conditions after opening.</LI><LI>3 months, ≤ -20 °C under sterile conditions after opening.</LI></UL></td> </tr> </tbody> </table> </div> </div> </div> </div> <div id="background" class="py-5 bt-pp-border-bottom" data-section="section-base--background-info"> <h3>Background: IL-15</h3> <article class="product-data-wrapper"> Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases (1, 2). Mature human IL-15 shares 70% amino acid sequence identity with mouse and rat IL-15. Alternative splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (3). IL-15 binds with high affinity to IL-15 R alpha (4). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gammac) which are also subunits of the IL-2 receptor complex (5). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (6). <div><br></div><div>The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta/ gammac on adjacent cells (7). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (6). In human and mouse, soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding and bind up nearly all the IL-15 in circulation (8-10). Soluble IL-15 R alpha functions as an inhibitor that limits IL-15 action (4, 9). Ligation of membrane-associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells (11). IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells (12 - 16). An important component of these functions is the ability of IL‑15 to induce dendritic cell differentiation and inflammatory activation (11, 14). IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8+ T cells (17). It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity (18). </div><div><br></div><div>Immunotherapy treatment with recombinant IL-15 has the advantage of not stimulating Treg cells like IL-2 does but has the drawback of associated toxicity at higher doses. This has led to increased investigation on mitigating IL-15 toxicity and combination immunotherapy approaches using immune checkpoint inhibitors (19, 20). Preclinical and early clinical studies have shown the potential of also using IL-15 in combination with cancer vaccines to improve their anti-tumor response (20). </div><div><br></div><div>IL-15 can also be used for the preconditioning of CAR T cells or for engineering cells to express IL-15 in vivo. Adoptive cell transfer of NK cells engineered to express CD19 and IL-15 were well tolerated in patients with CD19-positive cancers (20). IL-15 can be used in combination with other cytokines like IL-21 to increase the efficiency of NK cell expansion and maturation in stem cell culture protocols (21). The combination of IL-15 with IL-7 also promotes expansion of early-differentiated CD8+ T cells in culture with the added benefit of decreasing Treg cell generation, unlike IL-2, for adoptive cell transfer in cancer immunotherapy (22). GMP IL-7 and GMP IL-15 are commonly used in combination for ex vivo expansion of T cells for cellular therapies.</div> </article> <div id="background_wrapper" class="px-3 mt-2"> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>References</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <ol> <li>De Sabatino, A. <em>et al.</em> (2011) Cytokine Growth Factor Rev. <b>22</b>:19.</li> <li>Grabstein, K. <em>et al.</em> (1994) Science <b>264</b>:965.</li> <li>Tagaya, Y. <em>et al.</em> (1997) Proc. Natl. Acad. Sci. USA <b>94</b>:14444.</li> <li>Giri, J.G. <em>et al.</em> (1995) EMBO J. <b>14</b>:3654.</li> <li>Giri, J. <em>et al.</em> (1994) EMBO J. <b>13</b>:2822.</li> <li>Dubois, S. <em>et al.</em> (2002) Immunity <b>17</b>:537.</li> <li>Castillo, E.F. and K.S. Schluns (2012) Cytokine <b>59</b>:479.</li> <li>Budagian, V. <em>et al.</em> (2004) J. Biol. Chem. <b>279</b>:40368.</li> <li>Mortier, E. <em>et al.</em> (2004) J. Immunol. <b>173</b>:1681.</li> <li>Bergamaschi, C. <em>et al.</em> (2012) Blood <b>120</b>:e1.</li> <li>Budagian, V. <em>et al.</em> (2004) J. Biol. Chem. <b>279</b>:42192.</li> <li>Mortier, E. <em>et al.</em> (2003) J. Exp. Med. <b>205</b>:1213.</li> <li>Gordy, L.E. <em>et al.</em> (2011) J. Immunol. <b>187</b>:6335.</li> <li>Harris, K.M. (2011) J. Leukoc. Biol. <b>90</b>:727.</li> <li>Xia, J. <em>et al.</em> (2010) Clin. Immunol. <b>134</b>:130.</li> <li>Schluns, K.S. <em>et al.</em> (2002) J. Immunol. <b>168</b>:4827.</li> <li>Davies, E. <em>et al.</em> (2010) J. Leukoc. Biol. <b>88</b>:529.</li> <li>Barra, N.G. <em>et al.</em> (2010) Obesity <b>18</b>:1601.</li><li>Xue, D. <em>et al.</em> (2021) Antib Ther. <b>4</b>:123.</li><li>Wolfarth, A.A. <em>et al.</em> (2022) Immune Netw. <b>22</b>:e5.</li><li>Oberoi, P. <em>et al.</em> (2020) Cells. <b>9</b>:811.</li><li>Chamucero-Millares, J.A. <em>et al.</em> (2021) Cellular Immunol. <b>360</b>:104257.</li></ol> </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Long Name</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> Interleukin 15 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Alternate Names</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> IL15 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Entrez Gene IDs</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.ncbi.nlm.nih.gov/gene?term=3600" class="a___link-external" target="_blank" rel="nofollow">3600</a> (Human); <a href="https://www.ncbi.nlm.nih.gov/gene?term=16168" class="a___link-external" target="_blank" rel="nofollow">16168</a> (Mouse); <a href="https://www.ncbi.nlm.nih.gov/gene?term=25670" class="a___link-external" target="_blank" rel="nofollow">25670</a> (Rat); <a href="https://www.ncbi.nlm.nih.gov/gene?term=102119613" class="a___link-external" target="_blank" rel="nofollow">102119613</a> (Cynomolgus Monkey); <a href="https://www.ncbi.nlm.nih.gov/gene?term=493682" class="a___link-external" target="_blank" rel="nofollow">493682</a> (Feline) </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Gene Symbol</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> IL15 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>UniProt</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.uniprot.org/uniprot/?query=P40933.1" class="a___link-external" target="_blank" rel="nofollow">P40933.1</a> </div> </div> </div> <h4 class="mt-3">Additional IL-15 Products</h4> <ul class="list-unstyled"> <li><a href="/t/il-15" data-product="IL-15">All Products for IL-15 </a></li> <li><a href="/t/il-15/cdna-clones" data-application="IL-15 cDNA Clones">IL-15 cDNA Clones </a></li> <li><a href="/t/il-15/elisa-kits" data-application="IL-15 ELISA Kits">IL-15 ELISA Kits </a></li> <li><a href="/t/il-15/luminex-assays" data-application="IL-15 Luminex Assays">IL-15 Luminex Assays </a></li> <li><a href="/t/il-15/lysates" data-application="IL-15 Lysates">IL-15 Lysates </a></li> <li><a href="/t/il-15/antibodies" data-application="IL-15 Primary Antibodies">IL-15 Primary Antibodies </a></li> <li><a href="/t/il-15/proteins-enzymes" data-application="IL-15 Proteins and Enzymes">IL-15 Proteins and Enzymes </a></li> <li><a href="/t/il-15/simple-plex" data-application="IL-15 Simple Plex">IL-15 Simple Plex </a></li> </ul> </div> <div id="product-documents" data-section="section-base--product-documents"> <div id="accordion" class="border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3"> Product Documents for Recombinant Human IL-15 GMP Protein, CF </h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#accordion"> <div class="card-body"> <div class="row mt-2"> <div class="col-md-6"> <a href="https:/datasheet-pdf/?src=rnd&pdf=bt-015-gmp_lq.pdf" class="datasheet_link" target="_blank" rel="nofollow">Download Product Datasheets: BT-015-GMP/LQ (liquid)</a> </div> </div> </div> </div> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#accordion"> <div class="card-body"> <form novalidate="novalidate" data-drupal-selector="product-coa-form" action="#coa-form" method="post" id="product-coa-form" accept-charset="UTF-8"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please enter a lot number in the search box below.</p> <p><strong>Note:</strong> Certificate of Analysis not available for kit components.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form 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Ph. 5.2.12, Raw Materials of Biological Origin for the Production of Cell-based and Gene Therapy Medicinal Products. <br><br><br>R&D Systems' quality focus includes:<br><br><ul><li>Manufactured and tested under an ISO 9001:2015 and ISO 13485:2016 certified quality system</li><li>Documented processes and QA control of documentation and process changes</li><li>Personnel training programs</li><li>Raw material testing and vendor qualification/monitoring</li><li>Fully validated equipment, processes and test methods</li><li>Equipment calibration schedules using a computerized calibration program</li><li>Facility maintenance, safety programs and pest control</li><li>Material review process for variances</li><li>Monitoring of stability over product shelf-life</li></ul><br><br>R&D Systems strives to provide our customers with the analytical characteristics of each product so that customers may determine whether our products are appropriate for their research. The Certificate of Analysis provided contains the following lot specific information: <br><br><ul><li>N-terminal amino acid analysis, SDS-PAGE analysis, and endotoxin level (as determined by LAL assay) performed on each bulk QC lot, not on individual bottlings of each QC lot</li><li>Post-bottling lot-specific bioassay results (compliance with an established range) and results of microbial testing according to USP <71></li><li>Host Cell Protein testing performed by ELISA</li><li>Mycoplasma testing by ribosomal RNA hybridization assay</li></ul><br><br>Additional testing and documentation requested by the customer can be arranged at an additional cost.<br><br> Production records and facilities are available for examination by appropriate personnel on-site at R&D Systems. <br><br> R&D Systems sells GMP grade products for preclinical or clinical <em>ex vivo</em> cell therapy applications. They are not for <em>in vivo</em> use. Please read the following End User Terms prior to using this product.<br><br>Animal-Free Manufacturing Conditions<br> Our dedicated controlled-access animal-free laboratories ensure that at no point in production are the products exposed to potential contamination by animal components or byproducts. Every stage of manufacturing is conducted in compliance with R&D Systems' stringent Standard Operating Procedures (SOPs). Production and purification procedures use equipment and media that are confirmed animal-free.<br><br> Production<br><br><ul><li>All molecular biology procedures use animal-free media and dedicated labware.</li><li>Dedicated fermentors are utilized in committed animal-free areas.<br><br></li></ul> Purification<br><br><ul><li>Protein purification columns are animal-free.</li><li>Bulk proteins are filtered using animal-free filters.</li><li>Purified proteins are stored in animal-free containers in a dedicated cold storage room.</li></ul><br>Quality Assurance <br><br><ul><li>Low Endotoxin Level.</li><li>No impairment of biological activity. </li><li>High quality product obtained under stringent conditions. <br><br></li></ul><a target="_blank" href="https://www.rndsystems.com/products/animal-free-statement">Please read our complete Animal-Free Statement.</a> </div> <div id="specific-notices" class="py-5" data-section="section-base--specific-notices"> <h3>Product Specific Notices for Recombinant Human IL-15 GMP Protein, CF </h3> <p></p><p><b>END USER TERMS OF USE OF PRODUCT</b></p> <p>The following terms are offered to you upon your acceptance of these End User Terms of Use of Product. By using this product, you indicate your acknowledgment and agreement to these End User Terms of Use of Product. If you do not agree to be bound by and comply with all of the provisions of these End User Terms of Use of Product, you should contact your supplier of the product and make arrangements to return the product.</p> <p>We suggest you print and retain a copy of these End User Terms of Use of Product for your records.</p> <p>The End User is aware that R&D Systems, Inc. sells GMP products for preclinical or clinical <em>ex vivo</em> use and not for <em>in vivo</em> use. The End User further agrees, as a condition of the sale of R&D Systems' GMP products that: a) the End User will not use this GMP Product in any procedure wherein the product may be directly or indirectly administered to humans, unless the End User has obtained, or prior to their use will have obtained, an Investigational New Drug (IND) exemption from the FDA and will use the product only in accordance with the protocols of such IND and of the Institutional Review Board overseeing the proposed research, or b) the End User will use the products outside of the United States in accordance with the protocols of research approved by the Institutional Review Board or authorized ethics committee and regulatory agencies to which the End User is subject to in their territory.</p> <p>R&D Systems, Inc. has the right, at its sole discretion, to modify, add or remove any terms or conditions of these End User Terms of Use without notice or liability to you. Any changes to these End User Terms of Use are effective immediately following the printing of such changes on this product insert. The most recent version of these End User Terms of Use of Product may be found at: RnDSystems.com/Legal.</p> <p>You agree to review these End User Terms of Use of Product to ensure any subsequent use by you of R&D Systems' GMP Products following changes to these End User Terms of Use of Product constitutes your acceptance of all such changes.</p> <p> </p> <p><b>TERMS AND CONDITIONS</b></p> <p>The following limitation applies to R&D Systems' warranty and liability for damages: All products are warranted to meet R&D Systems' published specifications when used under normal laboratory conditions.</p> <p>R&D SYSTEMS DOES NOT MAKE ANY OTHER WARRANTY OR REPRESENTATION WHATSOEVER, WHETHER EXPRESS OR IMPLIED, WITH RESPECT TO ITS PRODUCTS. IN PARTICULAR, R&D SYSTEMS DOES NOT MAKE ANY WARRANTY OF SUITABILITY, NONINFRINGEMENT, MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE.</p> <p>NOTWITHSTANDING ANY OTHER PROVISIONS OF THESE TERMS AND/OR ANY OTHER AGREEMENT BETWEEN R&D SYSTEMS AND PURCHASER FOR THE PURCHASE OF THE PRODUCTS, R&D SYSTEMS' TOTAL LIABILITY TO PURCHASER ARISING FROM OR IN RELATION TO THESE TERMS, AN AGREEMENT BETWEEN THE PARTIES OR THE PRODUCTS, WHETHER ARISING IN CONTRACT, TORT OR OTHERWISE SHALL BE LIMITED TO THE TOTAL AMOUNT PAID BY PURCHASER TO R&D SYSTEMS FOR THE APPLICABLE PRODUCTS. IN NO EVENT WILL R&D SYSTEMS BE LIABLE FOR THE COST OF PROCUREMENT OF SUBSTITUTE GOODS. </p> <p>Full details of R&D Systems' Terms and Conditions of Sale can be found online at: RnDSystems.com/Legal.</p><p>For preclinical, or clinical <i>ex vivo</i> use</p> </div> </div> <div class="tab-pane fade" id="citations_reviews" role="tabpanel" aria-labelledby="citations_reviews-tab"> <div data-section="section-base--technical-anchors"> <ul class="product-pages-anchors nav mt-2"> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor active" href="#citations"> Citations</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#reviews"> Reviews</a> </li> </ul> </div> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="BT-015-GMP"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> <section 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