Publications - Hypoxia Lab

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src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/search-icon.svg" width="20" height="20" alt="search-icon" class="svg"/></a> <button aria-label="Display mobile menu" id="hamburger" class="right__hamburger"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#fff" stroke-linecap="round" stroke-width="1.5" d="M3 4.25h14m-14 6h14m-14 6h14"/></svg></button> </div> </div> </div> </header> <main class="DefaultTemplate"> <section class="TitleDescriptionImage TitleDescriptionImage__description--center" data-jsmodule="TitleDescriptionImage"> <div class="row"> <div class="TitleDescriptionImage__content"> <h1 class="content__heading">Publications</h1> <div class="content__description"><p>The Hypoxia Lab investigators have published more than 400 peer reviewed manuscripts. Below are some of these studies which include seminal work on blood gas analysis, pulse oximetry, human response to hypoxemia and high altitude.</p> </div> </div> <div class="image-wrapper image-wrapper--svg TitleDescriptionImage__image"> <div class="asset"> <picture class="lazy-load-item asset-loaded" data-alt="publication-heading-image-qcfxw2" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/publication-heading-image-qcfxw2.svg" data-loaded="true" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/publication-heading-image-qcfxw2.svg" sizes="100vw"> <img alt="publication-heading-image-qcfxw2"> </picture> </div> </div> </div> </section> <section class="PublicationsSection" data-jsmodule="PublicationsSection"> <div class="row"> <div class="PublicationsSection__content"> <div class="content__items"> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/38458110" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Leeb G</span>, <span>Auchus I</span>, <span>Law T</span>, <span>Bickler P</span>, <span>Feiner J</span>, <span>Hashi S</span>, <span>Monk E</span>, <span>Igaga E</span>, <span>Bernstein M</span>, <span>Chou YC</span>, <span>Hughes C</span>, <span>Schornack D</span>, <span>Lester J</span>, <span>Moore K Jr</span>, <span>Okunlola O</span>, <span>Fernandez J</span>, <span>Shmuylovich L</span>, <span>Lipnick M</span></p> <div class="PublicationTile__description"><p><em>EBioMedicine</em><br />PubDate: 2024 Apr<br /><span>PUBMED: 38458110</span> ; <span>PMC: PMC10943300</span> ; <span>DOI: 10.1016/j.ebiom.2024.105051</span> ; <span>PII: S2352-3964(24)00086-0</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgba(175,0,5,0.15);color: #af002e">Laboratory Desaturation Studies</li> <li class="terms__single" style="background-color: rgb(30,115,190);color: #ffffff">Open Oximetry Project</li> <li class="terms__single" style="background-color: rgba(0,42,196,0.15);color: #0004f2">Pulse Ox & Equity</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Background</h3> <p>Fingertip pulse oximeters are widely available, inexpensive, and commonly used to make clinical decisions in many settings. Device performance is largely unregulated and poorly characterised, especially in people with dark skin pigmentation.</p> <h3>Methods</h3> <p>Eleven popular fingertip pulse oximeters were evaluated using the US Food and Drug Administration (FDA) Guidance (2013) and International Organization for Standardization Standards (ISO, 2017) in 34 healthy humans with diverse skin pigmentation utilising a controlled desaturation study with arterial oxygen saturation (SaO 2) plateaus between 70% and 100%. Skin pigmentation was assessed subjectively using a perceived Fitzpatrick Scale (pFP) and objectively using the individual typology angle (ITA) via spectrophotometry at nine anatomical sites.</p> <h3>Findings</h3> <p>Five of 11 devices had a root mean square error (ARMS) > 3%, falling outside the acceptable FDA performance range. Nine devices demonstrated worse performance in participants in the darkest skin pigmentation category compared with those in the lightest category. A commonly used subjective skin colour scale frequently miscategorised participants as being darkly pigmented when compared to objective quantification of skin pigment by ITA.</p> <h3>Interpretation</h3> <p>Fingertip pulse oximeters have variable performance, frequently not meeting regulatory requirements for clinical use, and occasionally contradicting claims made by manufacturers. Most devices showed a trend toward worse performance in participants with darker skin pigment. Regulatory standards do not adequately account for the impact of skin pigmentation on device performance. We recommend that the pFP and other non-standardised subjective skin colour scales should no longer be used for defining diversity of skin pigmentation. Reliable methods for characterising skin pigmentation to improve diversity and equitable performance of pulse oximeters are needed.</p> <h3>Funding</h3> <p>This study was conducted as part of the Open Oximetry Project funded by the Gordon and Betty Moore Foundation, Patrick J McGovern Foundation, and Robert Wood Johnson Foundation. The UCSF Hypoxia Research Laboratory receives funding from multiple industry sponsors to test the sponsors’ devices for the purposes of product development and regulatory performance testing. Data in this paper do not include sponsor’s study devices. All data were collected from devices procured by the Hypoxia Research Laboratory for the purposes of independent research. No company provided any direct funding for this study, participated in study design or analysis, or was involved in analysing data or writing the manuscript. None of the authors own stock or equity interests in any pulse oximeter companies. Dr Ellis Monk’s time utilised for data analysis, reviewing and editing was funded by grant number: DP2MH132941.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin: A Prospective Study.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/38109495" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Gudelunas MK</span>, <span>Lipnick M</span>, <span>Hendrickson C</span>, <span>Vanderburg S</span>, <span>Okunlola B</span>, <span>Auchus I</span>, <span>Feiner JR</span>, <span>Bickler PE</span></p> <div class="PublicationTile__description"><p><em>Anesthesia and analgesia</em><br />PubDate: 2023 Dec 19<br /><span>PUBMED: 38109495</span> ; <span>DOI: 10.1213/ANE.0000000000006755</span> ; <span>PII: 00000539-990000000-00686</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgba(175,0,5,0.15);color: #af002e">Laboratory Desaturation Studies</li> <li class="terms__single" style="background-color: rgba(0,42,196,0.15);color: #0004f2">Pulse Ox & Equity</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Background</h3> <p>Retrospective clinical trials of pulse oximeter accuracy report more frequent missed diagnoses of hypoxemia in hospitalized Black patients than White patients, differences that may contribute to racial disparities in health and health care. Retrospective studies have limitations including mistiming of blood samples and oximeter readings, inconsistent use of functional versus fractional saturation, and self-reported race used as a surrogate for skin color. Our objective was to prospectively measure the contributions of skin pigmentation, perfusion index (PI), sex, and age on pulse oximeter errors in a laboratory setting.</p> <h3>Methods</h3> <p>We enrolled 146 healthy subjects, including 25 with light skin (Fitzpatrick class I and II), 78 with medium (class III and IV), and 43 with dark (class V and VI) skin. We studied 2 pulse oximeters (Nellcor N-595 and Masimo Radical 7) in prevalent clinical use. We analyzed 9763 matched pulse oximeter readings (pulse oximeter measured functional saturation [Spo2]) and arterial oxygen saturation (hemoximetry arterial functional oxygen saturation [Sao2]) during stable hypoxemia (Sao2 68%-100%). PI was measured as percent infrared light modulation by the pulse detected by the pulse oximeter probe, with low perfusion categorized as PI < 1%. The primary analysis was to assess the relationship between pulse oximeter bias (difference between Sao2 and Spo2) by skin pigment category in a multivariable mixed-effects model incorporating repeated-measures and different levels of Sao2 and perfusion.</p> <h3>Results</h3> <p>Skin pigment, PI, and degree of hypoxemia significantly contributed to errors (bias) in both pulse oximeters. For PI values of 1.0% to 1.5%, 0.5% to 1.0%, and <0.5%, the P value of the relationship to mean bias or median absolute bias was <.00001. In lightly pigmented subjects, only PI was associated with positive bias, whereas in medium and dark subjects bias increased with both low perfusion and degree of hypoxemia. Sex and age was not related to pulse oximeter bias. The combined frequency of missed diagnosis of hypoxemia (pulse oximeter readings 92%-96% when arterial oxygen saturation was <88%) in low perfusion conditions was 1.1% for light, 8.2% for medium, and 21.1% for dark skin.</p> <h3>Conclusions</h3> <p>Low peripheral perfusion combined with darker skin pigmentation leads to clinically significant high-reading pulse oximeter errors and missed diagnoses of hypoxemia. Darkly pigmented skin and low perfusion states are likely the cause of racial differences in pulse oximeter performance in retrospective studies.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Quantifying pulse oximeter accuracy during hypoxemia and severe anemia using an in vitro circulation system.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/37266710" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Gylys R</span>, <span>Feiner J</span>, <span>Pologe J</span>, <span>Delianides T</span>, <span>Sutter S</span>, <span>Bickler P</span>, <span>Lipnick MS</span></p> <div class="PublicationTile__description"><p><em>Journal of clinical monitoring and computing</em><br />PubDate: 2023 Dec<br /><span>PUBMED: 37266710</span> ; <span>PMC: PMC10651532</span> ; <span>DOI: 10.1007/s10877-023-01031-3</span> ; <span>PII: 10.1007/s10877-023-01031-3</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgb(221,153,51);color: #ffffff">In Vitro Studies</li> <li class="terms__single" style="background-color: rgb(30,115,190);color: #ffffff">Open Oximetry Project</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>Anemia and hypoxemia are common clinical conditions that are difficult to study and may impact pulse oximeter performance. Utilizing an in vitro circulation system, we studied performance of three pulse oximeters during hypoxemia and severe anemia. Three oximeters including one benchtop, one handheld, and one fingertip device were selected to reflect a range of cost and device types. Human blood was diluted to generate four hematocrit levels (40%, 30%, 20%, and 10%). Oxygen and nitrogen were bubbled through the blood to generate a range of oxygen saturations (OHb) and the blood was cycled through the in vitro circulation system. Pulse oximeter saturations (SpO) were paired with simultaneously-measured OHb readings from a reference CO-oximeter. Data for each hematocrit level and each device were least-squares fit to a 2nd-order equation with quality of each curve fit evaluated using standard error of the estimate. Bias and average root mean square error were calculated after correcting for the calibration difference between human and in vitro circulation system calibration. The benchtop oximeter maintained good accuracy at all but the most extreme level of anemia. The handheld device was not as accurate as the benchtop, and inaccuracies increased at lower hematocrit levels. The fingertip device was the least accurate of the three oximeters. Pulse oximeter performance is impacted by severe anemia in vitro. The use of in vitro calibration systems may play an important role in augmenting in vivo performance studies evaluating pulse oximeter performance in challenging conditions.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Pulse Oximeter Performance, Racial Inequity, and the Work Ahead.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/34772785" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Okunlola OE</span>, <span>Lipnick MS</span>, <span>Batchelder PB</span>, <span>Bernstein M</span>, <span>Feiner JR</span>, <span>Bickler PE</span></p> <div class="PublicationTile__description"><p><em>Respiratory care</em><br />PubDate: 2022 Feb<br /><span>PUBMED: 34772785</span> ; <span>DOI: 10.4187/respcare.09795</span> ; <span>PII: respcare.09795</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgba(0,42,196,0.15);color: #0004f2">Pulse Ox & Equity</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>It has long been known that many pulse oximeters function less accurately in patients with darker skin. Reasons for this observation are incompletely characterized and potentially enabled by limitations in existing regulatory oversight. Based on decades of experience and unpublished data, we believe it is feasible to fully characterize, in the public domain, the factors that contribute to missing clinically important hypoxemia in patients with darkly pigmented skin. Here we propose 5 priority areas of inquiry for the research community and actionable changes to current regulations that will help improve oximeter accuracy. We propose that leading regulatory agencies should immediately modify standards for measuring accuracy and precision of oximeter performance, analyzing and reporting performance outliers, diversifying study subject pools, thoughtfully defining skin pigmentation, reporting data transparently, and accounting for performance during low-perfusion states. These changes will help reduce bias in pulse oximeter performance and improve access to safe oximeters.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/29189269" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Lipnick MS</span>, <span>Cahill EA</span>, <span>Feiner JR</span>, <span>Bickler PE</span></p> <div class="PublicationTile__description"><p><em>Anesthesia and analgesia</em><br />PubDate: 2018 Feb<br /><span>PUBMED: 29189269</span> ; <span>DOI: 10.1213/ANE.0000000000002590</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgba(0,42,196,0.15);color: #0004f2">Pulse Ox & Equity</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Background</h3> <p>Currently, no reliable method exists for continuous, noninvasive measurements of absolute cerebral blood flow (CBF). We sought to determine how changes measured by ultrasound-tagged near-infrared spectroscopy (UT-NIRS) compare with changes in CBF as measured by transcranial Doppler (TCD) in healthy volunteers during profound hypocapnia and hypercapnia.</p> <h3>Methods</h3> <p>Ten healthy volunteers were monitored with a combination of TCD, UT-NIRS (c-FLOW, Ornim Medical), as well as heart rate, blood pressure, end-tidal PCO2 (PEtCO2), end-tidal O2, and inspired O2. Inspired CO2 and minute ventilation were controlled to achieve 5 stable plateau goals of EtCO2 at 15-20, 25-30, 35-40, 45-50, and 55-60 mm Hg, for a total of 7 measurements per subject. CBF was assessed at a steady state, with the TCD designated as the reference standard. The primary analysis was a linear mixed-effect model of TCD and UT-NIRS flow with PEtCO2, which accounts for repeated measures. Receiver operating characteristic curves were determined for detection of changes in CBF.</p> <h3>Results</h3> <p>Hyperventilation (nadir PEtCO2 17.1 ± 2.4) resulted in significantly decreased mean flow velocity of the middle cerebral artery from baseline (to 79% ± 22%), but not a consistent decrease in UT-NIRS cerebral flow velocity index (n = 10; 101% ± 6% of baseline). Hypercapnia (peak PEtCO2 59.3 ± 3.3) resulted in a significant increase from baseline in both mean flow velocity of the middle cerebral artery (153% ± 25%) and UT-NIRS (119% ± 11%). Comparing slopes versus PEtCO2 as a percent of baseline for the TCD (1.7% [1.5%-2%]) and UT-NIRS (0.4% [0.3%-0.5%]) shows that the UT-NIRS slope is significantly flatter, P < .0001. Area under the receiver operating characteristic curve was significantly higher for the TCD than for UT-NIRS, 0.97 (95% confidence interval, 0.92-0.99) versus 0.75 (95% confidence interval, 0.66-0.82).</p> <h3>Conclusions</h3> <p>Our data indicate that UT-NIRS cerebral flow velocity index detects changes in CBF only during hypercarbia but not hypocarbia in healthy subjects and with much less sensitivity than TCD. Additional refinement and validation are needed before widespread clinical utilization of UT-NIRS.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Pulse Oximeter Bias and Inequities in Retrospective Studies–Now What?</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/36442988" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Moore KL Jr</span>, <span>Gudelunas K</span>, <span>Lipnick MS</span>, <span>Bickler PE</span>, <span>Hendrickson CM</span></p> <div class="PublicationTile__description"><p><em>Respiratory care</em><br />PubDate: 2022 Dec<br /><span>PUBMED: 36442988</span> ; <span>DOI: 10.4187/respcare.10654</span> ; <span>PII: 67/12/1633</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Comment</li> <li class="terms__single">Editorial</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgb(30,115,190);color: #ffffff">Open Oximetry Project</li> <li class="terms__single" style="background-color: rgba(0,42,196,0.15);color: #0004f2">Pulse Ox & Equity</li> </ul> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">The Pulse Oximeter Is Amazing, but Not Perfect.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/35303063" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler P</span>, <span>Tremper KK</span></p> <div class="PublicationTile__description"><p><em>Anesthesiology</em><br />PubDate: 2022 May 1<br /><span>PUBMED: 35303063</span> ; <span>DOI: 10.1097/ALN.0000000000004171</span> ; <span>PII: 135875</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Comment</li> <li class="terms__single">Editorial</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgb(30,115,190);color: #ffffff">Open Oximetry Project</li> <li class="terms__single" style="background-color: rgba(0,42,196,0.15);color: #0004f2">Pulse Ox & Equity</li> </ul> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">John W. Severinghaus, M.D., 1922 to 2021.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/34499145" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler PE</span>, <span>Hornbein T</span>, <span>Saidman LJ</span></p> <div class="PublicationTile__description"><p><em>Anesthesiology</em><br />PubDate: 2021 Oct 1<br /><span>PUBMED: 34499145</span> ; <span>DOI: 10.1097/ALN.0000000000003927</span> ; <span>PII: 117106</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Biography</li> <li class="terms__single">Editorial</li> <li class="terms__single">Historical Article</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgba(97,0,150,0.89);color: #ffffff">High Altitude</li> </ul> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Association between tissue oxygenation and myocardial injury in patients undergoing major spine surgery: a prospective cohort study.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/34535471" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bernholm KF</span>, <span>Meyhoff CS</span>, <span>Bickler P</span></p> <div class="PublicationTile__description"><p><em>BMJ open</em><br />PubDate: 2021 Sep 17<br /><span>PUBMED: 34535471</span> ; <span>PMC: PMC8451303</span> ; <span>DOI: 10.1136/bmjopen-2020-044342</span> ; <span>PII: bmjopen-2020-044342</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgba(97,0,150,0.89);color: #ffffff">High Altitude</li> <li class="terms__single" style="background-color: rgba(198,125,0,0.15);color: #ba8e00">Tissue Oximetry</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Objective</h3> <p>To describe the association between intraoperative tissue oxygenation and postoperative troponin elevation in patients undergoing major spine surgery. We hypothesised that a decrease in intraoperative skeletal muscle tissue oxygenation (SmO) was associated with the peak postoperative cardiac troponin value.</p> <h3>Design</h3> <p>This is a prospective cohort study.</p> <h3>Setting</h3> <p>Single-centre, University of California San Francisco Medical Center.</p> <h3>Participants</h3> <p>Seventy adult patients undergoing major elective spine surgery.</p> <h3>Primary and secondary outcome measures</h3> <p>High-sensitivity troponin T (hsTnT) was measured in plasma preoperatively and on the first and second day after surgery to assess the primary outcome of peak postoperative hsTnT. Secondary outcomes included MINS and intensive care unit (ICU) admission within 30 days. Skeletal cerebral tissue oxygenation and SmO was measured continuously with near-infrared spectroscopy during surgery. The primary exposure variable was time-weighted area under the curve (TW AUC) for SmO.</p> <h3>Results</h3> <p>Mean age was 65 (33-85) years and 59% were female. No significant association was found between TW AUC for SmO and peak hsTnT (Spearman’s correlation, r=0.17, p=0.16). A total of 28 (40%) patients had MINS. ICU admission occurred in 14 (40%) in lower vs 25 (71%) in upper half of patients based on TW AUC for SmO, p=0.008.</p> <h3>Conclusions</h3> <p>Decrease in SmO was not a statistically significant predictor for peak troponin value following major spine surgery but is a potential predictor for other postoperative complications.</p> <h3>Trial registration number</h3> <p>NCT03518372.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Accuracy of Samsung Smartphone Integrated Pulse Oximetry Meets Full FDA Clearance Standards for Clinical Use.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/33619504" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Browne SH</span>, <span>Bernstein M</span>, <span>Bickler PE</span></p> <div class="PublicationTile__description"><p><em>medRxiv : the preprint server for health sciences</em><br />PubDate: 2021 Feb 18<br /><span>PUBMED: 33619504</span> ; <span>PMC: PMC7899474</span> ; <span>DOI: 10.1101/2021.02.17.21249755</span> ; <span>PII: 2021.02.17.21249755</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgba(175,0,5,0.15);color: #af002e">Laboratory Desaturation Studies</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Background</h3> <p>Pulse oximetry is used as an assessment tool to gauge the severity of COVID-19 infection and identify patients at risk of poor outcomes. The pandemic highlights the need for accurate pulse oximetry, particularly at home, as infection rates increase in multiple global regions including the UK, USA and South Africa. Over 100 million Samsung smartphones containing dedicated biosensors (Maxim Integrated Inc, San Jose, CA) and preloaded Apps to perform pulse oximetry, are in use globally. We performed detailed in human hypoxia testing on the Samsung S9 smartphone to determine if this integrated hardware meets full FDA/ISO requirements for clinical pulse oximetry.</p> <h3>Methods</h3> <p>The accuracy of integrated pulse oximetry in the Samsung 9 smartphone during stable arterial oxygen saturations (SaO) between 70% and 100% was evaluated in 12 healthy subjects. Inspired oxygen, nitrogen, and carbon dioxide partial pressures were monitored and adjusted via a partial rebreathing circuit to achieve stable target SaO plateaus between 70% and 100%. Arterial blood samples were taken at each plateau and saturation measured on each blood sample using ABL-90FLEX blood gas analyzer. Bias, calculated from smartphone readings minus the corresponding arterial blood sample, was reported as root mean square deviation (RMSD).</p> <h3>Findings</h3> <p>The RMSD of the over 257 data points based on blood sample analysis obtained from 12 human volunteers tested was 2.6%.</p> <h3>Interpretation</h3> <p>Evaluation of the smartphone pulse oximeter performance is within requirements of <3.5% RMSD blood oxygen saturation (SpO) value for FDA/ISO clearance for clinical pulse oximetry. This is the first report of smartphone derived pulse oximetry measurements that meet full FDA/ISO accuracy certification requirements. Both Samsung S9 and S10 contain the same integrated pulse oximeter, thus over 100 million smartphones in current global circulation could be used to obtain clinically accurate spot SpO measurements to support at home assessment of COVID-19 patients.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">“Silent” Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/32970134" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler PE</span>, <span>Feiner JR</span>, <span>Lipnick MS</span>, <span>McKleroy W</span></p> <div class="PublicationTile__description"><p><em>Anesthesiology</em><br />PubDate: 2021 Feb 1<br /><span>PUBMED: 32970134</span> ; <span>PMC: PMC7523476</span> ; <span>DOI: 10.1097/ALN.0000000000003578</span> ; <span>PII: 110734</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single">Review</li> <li class="terms__single" style="background-color: rgba(0,181,3,0.15);color: #22ba00">Hypoxia Tolerance</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>Severe hypoxemia presents variably, and sometimes silently, without subjective complaints of dyspnea. The adequacy of cardiovascular compensation for oxygen delivery to tissues should be a focus in all hypoxemic patients.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Response to Burtscher re: “Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels”.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/30239230" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler P</span>, <span>Feiner JR</span>, <span>Lundeberg J</span></p> <div class="PublicationTile__description"><p><em>High altitude medicine & biology</em><br />PubDate: 2018 Sep<br /><span>PUBMED: 30239230</span> ; <span>DOI: 10.1089/ham.2018.0092</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Comment</li> <li class="terms__single">Letter</li> <li class="terms__single" style="background-color: rgba(97,0,150,0.89);color: #ffffff">High Altitude</li> <li class="terms__single" style="background-color: rgba(0,181,3,0.15);color: #22ba00">Hypoxia Tolerance</li> </ul> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/29924642" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Lundeberg J</span>, <span>Feiner JR</span>, <span>Schober A</span>, <span>Sall JW</span>, <span>Eilers H</span>, <span>Bickler PE</span></p> <div class="PublicationTile__description"><p><em>High altitude medicine & biology</em><br />PubDate: 2018 Sep<br /><span>PUBMED: 29924642</span> ; <span>DOI: 10.1089/ham.2017.0144</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single">Randomized Controlled Trial</li> <li class="terms__single" style="background-color: rgba(97,0,150,0.89);color: #ffffff">High Altitude</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Unlabelled</h3> <p>Lundeberg, Jenny, John R. Feiner, Andrew Schober, Jeffrey W. Sall, Helge Eilers, and Philip E. Bickler. Increased cytokines at high altitude: lack of effect of ibuprofen on acute mountain sickness, physiological variables or cytokine levels. High Alt Med Biol. 19:249-258, 2018.</p> <h3>Introduction</h3> <p>There is no consensus on the role of inflammation in high-altitude acclimatization.</p> <h3>Aims</h3> <p>To determine the effects of a nonsteroidal anti-inflammatory drug (ibuprofen 400 mg every 8 hours) on blood cytokines, acclimatization, acute mountain sickness (AMS, Lake Louise Score), and noninvasive oxygenation in brain and muscle in healthy volunteers.</p> <h3>Materials and methods</h3> <p>In this double-blind study, 20 volunteers were randomized to receive ibuprofen or placebo at sea level and for 48 hours at 3800 m altitude. Arterial, brain, and leg muscle saturation with near infrared spectroscopy, pulse oximetry, and heart rate were measured. Blood samples were collected for cytokine levels and cytokine gene expression.</p> <h3>Results</h3> <p>All of the placebo subjects and 8 of 11 ibuprofen subjects developed AMS at altitude (p = 0.22, comparing placebo and ibuprofen). On arrival at altitude, the oxygen saturation as measured by pulse oximetry (SO) was 84.5% ± 5.4% (mean ± standard deviation). Increase in blood interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF) levels occurred comparably in the placebo and ibuprofen groups (all not significant, univariate test by Wilcoxon rank sum). Increased IL-6 was associated with higher AMS scores (p = 0.002 by Spearman rank correlation). However, we found no difference or association in AMS score and blood or tissue oxygenation between the ibuprofen and placebo groups.</p> <h3>Conclusions</h3> <p>We found that ibuprofen, at the package-recommended adult dose, did not have a significant effect on altitude-related increases in cytokines, AMS scores, blood, or tissue oxygenation in a population of healthy subjects with a high incidence of AMS.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Accuracy of detection of carboxyhemoglobin and methemoglobin in human and bovine blood with an inexpensive, pocket-size infrared scanner.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/29513738" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler MP</span>, <span>Rhodes LJ</span></p> <div class="PublicationTile__description"><p><em>PloS one</em><br />PubDate: 2018<br /><span>PUBMED: 29513738</span> ; <span>PMC: PMC5841812</span> ; <span>DOI: 10.1371/journal.pone.0193891</span> ; <span>PII: PONE-D-17-37457</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>Detecting life-threatening common dyshemoglobins such as carboxyhemoglobin (COHb, resulting from carbon monoxide poisoning) or methemoglobin (MetHb, caused by exposure to nitrates) typically requires a laboratory CO-oximeter. Because of cost, these spectrophotometer-based instrument are often inaccessible in resource-poor settings. The aim of this study was to determine if an inexpensive pocket infrared spectrometer and smartphone (SCiO®Pocket Molecular Sensor, Consumer Physics Ltd., Israel) accurately detects COHb and MetHb in single drops of blood. COHb was created by adding carbon monoxide gas to syringes of heparinized blood human or cow blood. In separate syringes, MetHb was produced by addition of sodium nitrite solution. After incubation and mixing, fractional concentrations of COHb or MetHb were measured using a Radiometer ABL-90 Flex® CO-oximeter. Fifty microliters of the sample were then placed on a microscope slide, a cover slip applied and scanned with the SCiO spectrometer. The spectrograms were used to create simple linear models predicting [COHb] or [MetHb] based on spectrogram maxima, minima and isobestic wavelengths. Our model predicted clinically significant carbon monoxide poisoning (COHb ≥15%) with a sensitivity of 93% and specificity of 88% (regression r2 = 0.63, slope P<0.0001), with a mean bias of 0.11% and an RMS error of 21%. Methemoglobinemia severe enough to cause symptoms (>20% MetHb) was detected with a sensitivity of 100% and specificity of 71% (regression r2 = 0.92, slope P<0.001) mean bias 2.7% and RMS error 21%. Although not as precise as a laboratory CO-oximeter, an inexpensive pocket-sized infrared scanner/smartphone detects >15% COHb or >20% MetHb on a single drop of blood with enough accuracy to be useful as an initial clinical screening. The SCiO and similar relatively low cost spectrometers could be developed as inexpensive diagnostic tools for developing countries.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/29200008" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Louie A</span>, <span>Feiner JR</span>, <span>Bickler PE</span>, <span>Rhodes L</span>, <span>Bernstein M</span>, <span>Lucero J</span></p> <div class="PublicationTile__description"><p><em>Anesthesiology</em><br />PubDate: 2018 Mar<br /><span>PUBMED: 29200008</span> ; <span>DOI: 10.1097/ALN.0000000000002002</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgba(175,0,5,0.15);color: #af002e">Laboratory Desaturation Studies</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Background</h3> <p>Pulse oximeter performance is degraded by motion artifacts and low perfusion. Manufacturers developed algorithms to improve instrument performance during these challenges. There have been no independent comparisons of these devices.</p> <h3>Methods</h3> <p>We evaluated the performance of four pulse oximeters (Masimo Radical-7, USA; Nihon Kohden OxyPal Neo, Japan; Nellcor N-600, USA; and Philips Intellivue MP5, USA) in 10 healthy adult volunteers. Three motions were evaluated: tapping, pseudorandom, and volunteer-generated rubbing, adjusted to produce photoplethsmogram disturbance similar to arterial pulsation amplitude. During motion, inspired gases were adjusted to achieve stable target plateaus of arterial oxygen saturation (SaO2) at 75%, 88%, and 100%. Pulse oximeter readings were compared with simultaneous arterial blood samples to calculate bias (oxygen saturation measured by pulse oximetry [SpO2] – SaO2), mean, SD, 95% limits of agreement, and root mean square error. Receiver operating characteristic curves were determined to detect mild (SaO2 < 90%) and severe (SaO2 < 80%) hypoxemia.</p> <h3>Results</h3> <p>Pulse oximeter readings corresponding to 190 blood samples were analyzed. All oximeters detected hypoxia but motion and low perfusion degraded performance. Three of four oximeters (Masimo, Nellcor, and Philips) had root mean square error greater than 3% for SaO2 70 to 100% during any motion, compared to a root mean square error of 1.8% for the stationary control. A low perfusion index increased error.</p> <h3>Conclusions</h3> <p>All oximeters detected hypoxemia during motion and low-perfusion conditions, but motion impaired performance at all ranges, with less accuracy at lower SaO2. Lower perfusion degraded performance in all but the Nihon Kohden instrument. We conclude that different types of pulse oximeters can be similarly effective in preserving sensitivity to clinically relevant hypoxia.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/29084012" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Schober A</span>, <span>Feiner JR</span>, <span>Bickler PE</span>, <span>Rollins MD</span></p> <div class="PublicationTile__description"><p><em>Anesthesiology</em><br />PubDate: 2018 Jan<br /><span>PUBMED: 29084012</span> ; <span>DOI: 10.1097/ALN.0000000000001898</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgba(175,0,5,0.15);color: #af002e">Laboratory Desaturation Studies</li> <li class="terms__single" style="background-color: rgba(198,125,0,0.15);color: #ba8e00">Tissue Oximetry</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><h3>Background</h3> <p>Cerebral oximetry (cerebral oxygen saturation; ScO2) is used to noninvasively monitor cerebral oxygenation. ScO2 readings are based on the fraction of reduced and oxidized hemoglobin as an indirect estimate of brain tissue oxygenation and assume a static ratio of arterial to venous intracranial blood. Conditions that alter cerebral blood flow, such as acute changes in PaCO2, may decrease accuracy. We assessed the performance of two commercial cerebral oximeters across a range of oxygen concentrations during normocapnia and hypocapnia.</p> <h3>Methods</h3> <p>Casmed FORE-SIGHT Elite (CAS Medical Systems, Inc., USA) and Covidien INVOS 5100C (Covidien, USA) oximeter sensors were placed on 12 healthy volunteers. The fractional inspired oxygen tension was varied to achieve seven steady-state levels including hypoxic and hyperoxic PaO2 values. ScO2 and simultaneous arterial and jugular venous blood gas measurements were obtained with both normocapnia and hypocapnia. Oximeter bias was calculated as the difference between the ScO2 and reference saturation using manufacturer-specified weighting ratios from the arterial and venous samples.</p> <h3>Results</h3> <p>FORE-SIGHT Elite bias was greater during hypocapnia as compared with normocapnia (4 ± 9% vs. 0 ± 6%; P < 0.001). The INVOS 5100C bias was also lower during normocapnia (5 ± 15% vs. 3 ± 12%; P = 0.01). Hypocapnia resulted in a significant decrease in mixed venous oxygen saturation and mixed venous oxygen tension, as well as increased oxygen extraction across fractional inspired oxygen tension levels (P < 0.0001). Bias increased significantly with increasing oxygen extraction (P < 0.0001).</p> <h3>Conclusions</h3> <p>Changes in PaCO2 affect cerebral oximeter accuracy, and increased bias occurs with hypocapnia. Decreased accuracy may represent an incorrect assumption of a static arterial-venous blood fraction. Understanding cerebral oximetry limitations is especially important in patients at risk for hypoxia-induced brain injury, where PaCO2 may be purposefully altered.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Trends and Challenges in Clinical Monitoring: Papers From the 2015 IAMPOV Symposium.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/27551739" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler PE</span>, <span>Cannesson M</span>, <span>Shelley KH</span></p> <div class="PublicationTile__description"><p><em>Anesthesia and analgesia</em><br />PubDate: 2017 Jan<br /><span>PUBMED: 27551739</span> ; <span>DOI: 10.1213/ANE.0000000000001495</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Editorial</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> </ul> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Tissue Oximetry and Clinical Outcomes.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/27308951" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler P</span>, <span>Feiner J</span>, <span>Rollins M</span>, <span>Meng L</span></p> <div class="PublicationTile__description"><p><em>Anesthesia and analgesia</em><br />PubDate: 2017 Jan<br /><span>PUBMED: 27308951</span> ; <span>DOI: 10.1213/ANE.0000000000001348</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single">Review</li> <li class="terms__single" style="background-color: rgba(198,125,0,0.15);color: #ba8e00">Tissue Oximetry</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>A number of different technologies have been developed to measure tissue oxygenation, with the goal of identifying tissue hypoxia and guiding therapy to prevent patient harm. In specific cases, tissue oximetry may provide clear indications of decreases in tissue oxygenation such as that occurring during acute brain ischemia. However, the causation between tissue hemoglobin-oxygen desaturation in one organ (eg, brain or muscle) and global outcomes such as mortality, intensive care unit length of stay, and remote organ dysfunction remains more speculative. In this review, we describe the current state of evidence for predicting clinical outcomes from tissue oximetry and identify several issues that need to be addressed to clarify the link between tissue oxygenation and outcomes. We focus primarily on the expanding use of near-infrared spectroscopy to assess a venous-weighted mixture of venous and arterial hemoglobin-oxygen saturation deep in tissues such as brain and muscle. Our analysis finds that more work is needed in several areas: establishing threshold prediction values for tissue desaturation-related injury in specific organs, defining the types of interventions required to correct changes in tissue oxygenation, and defining the effect of interventions on outcomes. Furthermore, well-designed prospective studies that test the hypothesis that monitoring oxygenation status in one organ predicts outcomes related to other organs need to be done. Finally, we call for more work that defines regional variations in tissue oxygenation and improves technology for measuring and even imaging oxygenation status in critical organs. Such studies will contribute to establishing that monitoring and imaging of tissue oxygenation will become routine in the care of high-risk patients because the monitors will provide outputs that direct therapy to improve clinical outcomes.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/27529318" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Bickler PE</span>, <span>Feiner JR</span>, <span>Lipnick MS</span>, <span>Batchelder P</span>, <span>MacLeod DB</span>, <span>Severinghaus JW</span></p> <div class="PublicationTile__description"><p><em>Anesthesia and analgesia</em><br />PubDate: 2017 Jan<br /><span>PUBMED: 27529318</span> ; <span>DOI: 10.1213/ANE.0000000000001421</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Journal Article</li> <li class="terms__single">Review</li> <li class="terms__single" style="background-color: ;color: ">General Pulse Ox</li> <li class="terms__single" style="background-color: rgba(0,181,3,0.15);color: #22ba00">Hypoxia Tolerance</li> <li class="terms__single" style="background-color: rgba(175,0,5,0.15);color: #af002e">Laboratory Desaturation Studies</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>Extended periods of oxygen deprivation can produce acidosis, inflammation, energy failure, cell stress, or cell death. However, brief profound hypoxia (here defined as SaO2 50%-70% for approximately 10 minutes) is not associated with cardiovascular compromise and is tolerated by healthy humans without apparent ill effects. In contrast, chronic hypoxia induces a suite of adaptations and stresses that can result in either increased tolerance of hypoxia or disease, as in adaptation to altitude or in the syndrome of chronic mountain sickness. In healthy humans, brief profound hypoxia produces increased minute ventilation and increased cardiac output, but little or no alteration in blood chemistry. Central nervous system effects of acute profound hypoxia include transiently decreased cognitive performance, based on alterations in attention brought about by interruptions of frontal/central cerebral connectivity. However, provided there is no decrease in cardiac output or ischemia, brief profound hypoxemia in healthy humans is well tolerated without evidence of acidosis or lasting cognitive impairment.</p> </div> </div> </div> <div class="PublicationTile" data-jsmodule="PublicationTile"> <div class="PublicationTile__header"> <h2 class="header__title">Eight sages over five centuries share oxygen’s discovery.</h2> <a href="https://pubmed.ncbi.nlm.nih.gov/27458241" title="Open publication - link open in the new tab" target="_blank" class="header__link"> <span>Open publication</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-target-blank-blue.svg" width="20" height="20" alt="icon-target-blank-blue" class="svg"/> </a> </div> <p class="PublicationTile__authors"><span>Severinghaus JW</span></p> <div class="PublicationTile__description"><p><em>Advances in physiology education</em><br />PubDate: 2016 Sep<br /><span>PUBMED: 27458241</span> ; <span>DOI: 10.1152/advan.00076.2016</span> ; <span>PII: 40/3/370</span></p> </div> <div class="PublicationTile__row"> <ul class="row__terms"> <li class="terms__single">Historical Article</li> <li class="terms__single">Journal Article</li> <li class="terms__single" style="background-color: rgba(48,0,221,0.15);color: #0022e5">History</li> <li class="terms__single" style="background-color: ;color: ">Oxygen</li> <li class="terms__single" style="background-color: rgba(0,124,190,0.15);color: #bc51aa">Pulmonary</li> </ul> <button class="row__button" aria-label="Show abstract"> <span>Show abstract</span> <span>Hide abstract</span> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/chevron-down-black.svg" width="20" height="20" alt="chevron-down-black" class="svg"/> </button> </div> <div class="PublicationTile__wrapper"> <div class="wrapper__abstract"><p>During the last century, historians have discovered that between the 13th and 18th centuries, at least six sages discovered that the air we breathe contains something that we need and use. Ibn al-Nafis (1213-1288) in Cairo and Michael Servetus (1511-1553) in France accurately described the pulmonary circulation and its effect on blood color. Michael Sendivogius (1566-1636) in Poland called a part of air “the food of life” and identified it as the gas made by heating saltpetre. John Mayow (1641-1679) in Oxford found that one-fifth of air was a special gas he called “spiritus nitro aereus.” Carl Wilhelm Scheele (1742-1786) in Uppsala generated a gas he named “fire air” by heating several metal calcs. He asked Lavoisier how it fit the phlogiston theory. Lavoisier never answered. In 1744, Joseph Priestley (1733-1804) in England discovered how to make part of air by heating red calc of mercury. He found it brightened a flame and supported life in a mouse in a sealed bottle. He called it “dephlogisticated air.” He published and personally told Lavoisier and other chemists about it. Lavoisier never thanked him. After 9 years of generating and studying its chemistry, he couldn’t understand whether it was a new element. He still named it “principe oxigene.” He was still not able to disprove phlogiston. Henry Cavendish (1731-1810) made an inflammable gas in 1766. He and Priestley noted that its flame made a dew. Cavendish proved the dew was pure water and published this in 1778, but all scientists called it impossible to make water, an element. In 1783, on June 24th, Lavoisier was urged to try it, and, when water appeared, he realized that water was not an element but a compound of two gases, proving that oxygen was an element. He then demolished phlogiston and began the new chemistry revolution.</p> </div> </div> </div> <ul class="Pagination"> <li class="Pagination__item "> <div class="item__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m13 16-6-6 6-6"/></svg> </div> </li> <li class="Pagination__current">1</li> <li class="Pagination__item "> <button class="item__number" data-paged="2" aria-label="Go to next page"> 2 </button> </li> <li class="Pagination__item Pagination__item--last"> <button class="item__number" data-paged="8" aria-label="Go to last page"> 8 </button> </li> <li class="Pagination__item "> <button class="item__icon" data-paged="2" aria-label="Go to last page"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </button> </li> </ul> </div> <div 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