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<span>rigor</span></h1> </header> <article id="post-26006" class="post-26006 post type-post status-publish format-standard hentry category-blog category-open-mike tag-common-fund tag-reproducibility tag-rigor Issue-late-october-2024"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2024/10/29/a-pilot-approach-to-replicating-research-the-nih-common-funds-replication-to-enhance-research-impact-initiative-provides-funding-to-support-research-replication-activities/" rel="bookmark">A Pilot Approach To Replicating Research: The NIH Common Fund鈥檚 Replication to Enhance Research Impact Initiative Provides Funding To Support Research Replication Activities</a></h2> <div class="date-field">October 29, 2024</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/douglas-m-sheeley/" title="Posts by Douglas M. Sheeley" class="author url fn" rel="author">Douglas M. Sheeley</a></span></div></span> </div> <div><p>This summer, the NIH Office of Strategic Coordination launched the new Replication to Enhance Research Impact Initiative, a pilot approach to advance rigor and transparency in biomedical research by supporting the direct third-party replication of NIH-funded studies. Through the new Replication Initiative, we aim to test whether direct replication of selected research studies is a fruitful approach to enhancing research reproducibility, and if yes, for what types of studies, and under what circumstances.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/common-fund/" rel="tag">Common fund</a>, <a href="https://nexus.od.nih.gov/all/tag/reproducibility/" rel="tag">reproducibility</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2024/10/29/a-pilot-approach-to-replicating-research-the-nih-common-funds-replication-to-enhance-research-impact-initiative-provides-funding-to-support-research-replication-activities/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-25184" class="post-25184 post type-post status-publish format-standard hentry category-blog category-open-mike tag-alternatives-to-animals tag-animal-welfare tag-rigor Issue-february-2024"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2024/02/09/nih-director-statement-on-catalyzing-the-development-of-novel-alternative-methods/" rel="bookmark">NIH Director Statement on Catalyzing the Development of Novel Alternative Methods</a></h2> <div class="date-field">February 9, 2024</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/lauerm/" title="Posts by Mike Lauer" class="author url fn" rel="author">Mike Lauer</a></span></div></span> </div> <div><p>Last week, Dr. Monica Bertagnolli accepted recommendations from the Advisory Committee to the NIH Director on considering approaches that use novel alternative methods in biomedical and behavioral research. This is an exciting step in our ongoing efforts to support research that complements traditional models when scientifically feasible.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/alternatives-to-animals/" rel="tag">Alternatives to Animals</a>, <a href="https://nexus.od.nih.gov/all/tag/animal-welfare/" rel="tag">Animal Welfare</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">3</span> <a href="https://nexus.od.nih.gov/all/2024/02/09/nih-director-statement-on-catalyzing-the-development-of-novel-alternative-methods/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-25160" class="post-25160 post type-post status-publish format-standard hentry category-you-ask-we-answer tag-grants-policy tag-rigor Issue-february-2024"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2024/01/31/do-i-need-to-authenticate-key-biological-and-or-chemical-resources-if-so-how/" rel="bookmark">Do I Need to Authenticate Key Biological and/or Chemical Resources? If So, How?</a></h2> <div class="date-field">January 31, 2024</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/deansa/" title="Posts by NIH Staff" class="author url fn" rel="author">NIH Staff</a></span></div></span> </div> <div><p>NIH鈥檚 Rigor and Reproducibility FAQs have been updated with new questions and answers about authenticating key biological/chemical resources.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/grants-policy/" rel="tag">Grants policy</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2024/01/31/do-i-need-to-authenticate-key-biological-and-or-chemical-resources-if-so-how/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-24858" class="post-24858 post type-post status-publish format-standard hentry category-new-resources tag-animal-welfare tag-rigor Issue-october-2023"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2023/10/11/webinar-available-to-help-improve-animal-experimental-design/" rel="bookmark">Webinar Available to Help Improve Animal Experimental Design</a></h2> <div class="date-field">October 11, 2023</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/deansa/" title="Posts by NIH Staff" class="author url fn" rel="author">NIH Staff</a></span></div></span> </div> <div><p>The NIH office of Laboratory Animal Welfare (OLAW) released a webinar recording on how the NC3Rs Experimental Design Assistant (EDA) can assist researchers plan for their studies involving animals.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/animal-welfare/" rel="tag">Animal Welfare</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2023/10/11/webinar-available-to-help-improve-animal-experimental-design/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-24818" class="post-24818 post type-post status-publish format-standard hentry category-blog category-open-mike tag-animal-welfare tag-request-for-information tag-rigor Issue-late-september-2023"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2023/09/20/feedback-sought-on-cephalopod-care-and-use/" rel="bookmark">Feedback Sought on Cephalopod Care and Use</a></h2> <div class="date-field">September 20, 2023</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/lauerm/" title="Posts by Mike Lauer" class="author url fn" rel="author">Mike Lauer</a></span></div></span> </div> <div><p>Earlier this month, we released a Request for Information seeking public input on the humane care and use of laboratory cephalopods at Assured institutions. The proposed guidance acknowledges the evidence suggesting these animals would benefit from oversight, but also that there are not yet specific care and use standards to allow them to be regulated under the Public Health Service Policy for the Humane Care and Use of Laboratory Animals.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/animal-welfare/" rel="tag">Animal Welfare</a>, <a href="https://nexus.od.nih.gov/all/tag/request-for-information/" rel="tag">Request For Information (RFI)</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2023/09/20/feedback-sought-on-cephalopod-care-and-use/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-24653" class="post-24653 post type-post status-publish format-standard hentry category-blog category-open-mike tag-grants-policy tag-rigor Issue-august-2023"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2023/08/14/addressing-rigor-in-scientific-studies/" rel="bookmark">Addressing Rigor in Scientific Studies</a></h2> <div class="date-field">August 14, 2023</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/devon-c-crawford/" title="Posts by Devon C. Crawford" class="author url fn" rel="author">Devon C. Crawford</a></span></div></span> </div> <div><p>As聽NIH has been emphasizing聽for聽more than a decade, the聽rigor and transparency聽of a study are key for gleaning the robustness of its results. This includes the design, implementation, analysis, and interpretation of experiments.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/grants-policy/" rel="tag">Grants policy</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">2</span> <a href="https://nexus.od.nih.gov/all/2023/08/14/addressing-rigor-in-scientific-studies/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-24168" class="post-24168 post type-post status-publish format-standard hentry category-tips-before-you-submit tag-authentication tag-rigor Issue-late-march-2023"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2023/03/16/the-abcs-of-authentication-plans/" rel="bookmark">The ABCs of Authentication Plans</a></h2> <div class="date-field">March 16, 2023</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/deansa/" title="Posts by NIH Staff" class="author url fn" rel="author">NIH Staff</a></span></div></span> </div> <div><p>Are you proposing to use key biological and/or chemical resources like cell lines, specialty chemicals, antibodies, or other biologics in your application? Learn more about authentication plans.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/authentication/" rel="tag">authentication</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2023/03/16/the-abcs-of-authentication-plans/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-23803" class="post-23803 post type-post status-publish format-standard hentry category-blog category-open-mike tag-alternatives-to-animals tag-rigor Issue-february-2023"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2023/02/10/take-advantage-of-our-many-resources-for-enhancing-the-rigor-of-animal-research/" rel="bookmark">Take Advantage of Our Many Resources for Enhancing the Rigor of Animal Research</a></h2> <div class="date-field">February 10, 2023</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/lauerm/" title="Posts by Mike Lauer" class="author url fn" rel="author">Mike Lauer</a></span></div></span> </div> <div><p>The Advisory Committee to the NIH Director recommended ways for NIH to improve the rigor, reproducibility, and translatability of the research we support involving animal models. I updated the ACD this past June on our implementation of their recommendations. Here, in lieu of going through each of the report鈥檚 five themes, I will highlight some approaches raised during the meeting in response to their recommendations.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/alternatives-to-animals/" rel="tag">Alternatives to Animals</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">2</span> <a href="https://nexus.od.nih.gov/all/2023/02/10/take-advantage-of-our-many-resources-for-enhancing-the-rigor-of-animal-research/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-23350" class="post-23350 post type-post status-publish format-standard hentry category-new-resources tag-biological-variables tag-podcast tag-rigor tag-sabv Issue-july-2022"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2022/07/21/nih-all-about-grants-podcast-sex-as-a-biological-variable/" rel="bookmark">NIH All About Grants Podcast – Sex As a Biological Variable</a></h2> <div class="date-field">July 21, 2022</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/kosubd/" title="Posts by NIH Staff" class="author url fn" rel="author">NIH Staff</a></span></div></span> </div> <div><p>NIH expects that sex as a biological variable (SABV) will be factored into research designs, analyses, and reporting in pre-clinical and clinical studies. But, how exactly do you account for SABV? Dr. Chyren Hunter with the NIH Office of Research on Women鈥檚 Health explains more in this NIH All About Grants podcast episode.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/biological-variables/" rel="tag">biological variables</a>, <a href="https://nexus.od.nih.gov/all/tag/podcast/" rel="tag">podcast</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a>, <a href="https://nexus.od.nih.gov/all/tag/sabv/" rel="tag">SABV</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2022/07/21/nih-all-about-grants-podcast-sex-as-a-biological-variable/#comments">Comments</a></p> </div> </div> </div> </article> <article id="post-22580" class="post-22580 post type-post status-publish format-standard hentry category-blog category-open-mike tag-clinical-trials tag-rigor Issue-april-2022"> <div class="entry-list-content"> <div class="list-block"> <h2 class="entry-title"><a href="https://nexus.od.nih.gov/all/2022/03/14/whats-new-with-research-methods-resources-stepped-wedge-group-randomized-trials-and-more/" rel="bookmark">What鈥檚 New with Research Methods Resources: Stepped-Wedge Group Randomized Trials and More</a></h2> <div class="date-field">March 14, 2022</div> <div class="author-field"> <span><div class="author-meta">By <span><a href="https://nexus.od.nih.gov/all/author/dmurray/" title="Posts by David Murray" class="author url fn" rel="author">David Murray</a></span></div></span> </div> <div><p>We have been busy over the past several months and are happy to announce you can now find helpful resources for stepped wedge group-or cluster-randomized trials (SWGRTs) and more than 15 other study designs and methodological issues on the RMR website.</p> </div> <div class="tags-field"><a href="https://nexus.od.nih.gov/all/tag/clinical-trials/" rel="tag">Clinical Trials</a>, <a href="https://nexus.od.nih.gov/all/tag/rigor/" rel="tag">rigor</a></div> <div class="comments-bubble"> <p><span class="bubble number">0</span> <a href="https://nexus.od.nih.gov/all/2022/03/14/whats-new-with-research-methods-resources-stepped-wedge-group-randomized-trials-and-more/#comments">Comments</a></p> </div> </div> </div> </article> <nav class="navigation pagination" aria-label="Posts"> <h2 class="screen-reader-text">Posts navigation</h2> <div class="nav-links"><span aria-current="page" class="page-numbers current"><span class="meta-nav screen-reader-text">Page </span>1</span> <a class="page-numbers" href="https://nexus.od.nih.gov/all/tag/rigor/page/2/"><span class="meta-nav screen-reader-text">Page </span>2</a> <a class="page-numbers" href="https://nexus.od.nih.gov/all/tag/rigor/page/3/"><span class="meta-nav screen-reader-text">Page </span>3</a> <a class="next page-numbers" href="https://nexus.od.nih.gov/all/tag/rigor/page/2/">Next page</a></div> </nav> </main> </div> <aside id="secondary" class="sidebar widget-area" role="complementary"> <section id="nexus_widget-2" class="widget widget_nexus_widget"><div class="top-tags-wrapper"><a href="https://nexus.od.nih.gov/all/tag/grants-policy/" class="tag-cloud-link tag-link-43 tag-link-position-1" style="font-size: 13px;">Grants policy</a> <a href="https://nexus.od.nih.gov/all/tag/funding-data/" class="tag-cloud-link tag-link-40 tag-link-position-2" style="font-size: 13px;">Funding data</a> <a href="https://nexus.od.nih.gov/all/tag/general/" class="tag-cloud-link tag-link-41 tag-link-position-3" style="font-size: 13px;">General</a> <a href="https://nexus.od.nih.gov/all/tag/biomedical-research-workforce/" class="tag-cloud-link tag-link-217 tag-link-position-4" style="font-size: 13px;">Biomedical Research Workforce</a> <a href="https://nexus.od.nih.gov/all/tag/applications/" class="tag-cloud-link tag-link-32 tag-link-position-5" style="font-size: 13px;">applications</a> <a href="https://nexus.od.nih.gov/all/tag/peer-review/" class="tag-cloud-link tag-link-49 tag-link-position-6" style="font-size: 13px;">Peer review</a> <a href="https://nexus.od.nih.gov/all/tag/covid-19/" class="tag-cloud-link tag-link-450 tag-link-position-7" style="font-size: 13px;">COVID-19</a> <a href="https://nexus.od.nih.gov/all/tag/era-commons/" class="tag-cloud-link tag-link-67 tag-link-position-8" style="font-size: 13px;">eRA Commons</a> <a href="https://nexus.od.nih.gov/all/tag/human-subjects/" class="tag-cloud-link tag-link-93 tag-link-position-9" style="font-size: 13px;">human subjects</a> <a href="https://nexus.od.nih.gov/all/tag/podcast/" class="tag-cloud-link tag-link-50 tag-link-position-10" style="font-size: 13px;">podcast</a></div></section><section id="custom_html-3" class="widget_text widget widget_custom_html"><h2 class="widget-title">Suggestions?</h2><div class="textwidget custom-html-widget"><p> Is there a topic you'd like to see us address in the Extramural Nexus? 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