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"><video loop="loop" autoplay playsinline muted width="1174" height="720"> <source type="video/mp4" src="https://sspc.ie/wp-content/uploads/2019/11/Header5.mp4" /></video> </span><section id="home-hero-header-module" class="et_pb_module et_pb_fullwidth_header et_pb_fullwidth_header_0 et_pb_section_video_on_hover et_pb_text_align_center et_pb_bg_layout_dark et_pb_fullscreen"><div class="et_pb_fullwidth_header_container center"><div class="header-content-container center"><div class="header-content"> <img fetchpriority="high" decoding="async" width="450" height="405" src="https://sspc.ie/wp-content/uploads/2019/11/Hero_Header_Logo_White.png" title="" alt="" srcset="https://sspc.ie/wp-content/uploads/2019/11/Hero_Header_Logo_White.png 450w, https://sspc.ie/wp-content/uploads/2019/11/Hero_Header_Logo_White-300x270.png 300w" sizes="(max-width: 450px) 100vw, 450px" class="header-logo wp-image-64" /> <span class="et_pb_fullwidth_header_subhead">SSPC, Taighde Éireann – Research Ireland Centre for Pharmaceuticals</span><div class="et_pb_header_content_wrapper"><div class="jet-slider__desc"></div><div class="jet-slider__desc"><p><strong>SSPC, an Ionad Taighde FEÉ do Chógaisíocht</strong></p><p><span style="font-size: 21px;"> </span></p><p> </p><p>SSPC is a world-leading hub of Irish research expertise developing innovative technologies to address key challenges facing the pharmaceutical and biopharmaceutical industry. Our in-depth scientific and engineering research expertise aids companies who need tailored solutions to their bespoke challenges.</p></div></div></div></div></div><div class="et_pb_fullwidth_header_overlay"></div><div class="et_pb_fullwidth_header_scroll"></div></section></div><div class="et_pb_section et_pb_section_1 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_0"><div class="et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_blurb et_pb_blurb_0 et_pb_text_align_center et_pb_blurb_position_top et_pb_bg_layout_dark"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap"><span class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone et-pb-icon"></span></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Discover Our Impacts - Faigh amach faoinár dtionchair</span></h4><div class="et_pb_blurb_description"><p>SSPC provides the life sciences sector with a nationally distributed, research performing community that enables high impact, collaborative research between industry and academic partners.</p><p>SSPC is committed to translating its excellent science into impact through five societal goals: Sustainability, Small Molecule, Biologics, Health, Education and Public Engagement.</p></div></div></div></div></div></div><div id="impact-areas-row" class="et_pb_row et_pb_row_1 et_pb_gutters2"><div class="et_pb_column et_pb_column_1_5 et_pb_column_1 et_clickable et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_blurb et_pb_blurb_1 et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_light"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap et_pb_only_image_mode_wrap"><img loading="lazy" decoding="async" width="123" height="123" src="https://sspc.ie/wp-content/uploads/2023/03/Impact-Sustainability-Icon.png" alt="" class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone wp-image-12150" /></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Sustainability</span></h4></div></div></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_2 et_clickable et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_blurb et_pb_blurb_2 et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_light"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap et_pb_only_image_mode_wrap"><img loading="lazy" decoding="async" width="123" height="123" src="https://sspc.ie/wp-content/uploads/2023/03/Impact-Small-Molecule-Icon.png" alt="" class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone wp-image-12151" /></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Small Molecule</span></h4></div></div></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_3 et_clickable et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_blurb et_pb_blurb_3 et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_light"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap et_pb_only_image_mode_wrap"><img loading="lazy" decoding="async" width="123" height="123" src="https://sspc.ie/wp-content/uploads/2023/03/Impact-Large-Molecule-Icon.png" alt="" class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone wp-image-12152" /></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Biologics</span></h4></div></div></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_4 et_clickable et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_blurb et_pb_blurb_4 et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_light"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap et_pb_only_image_mode_wrap"><img loading="lazy" decoding="async" width="123" height="123" src="https://sspc.ie/wp-content/uploads/2023/03/Impact-Health-Icon.png" alt="" class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone wp-image-12153" /></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Health</span></h4></div></div></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_5 et_clickable et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_blurb et_pb_blurb_5 et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_light"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap et_pb_only_image_mode_wrap"><img loading="lazy" decoding="async" width="123" height="123" src="https://sspc.ie/wp-content/uploads/2023/03/Impact-Education-Public-Engagement-Icon.png" alt="" class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone wp-image-12154" /></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Education & Public Engagement</span></h4></div></div></div></div></div><div class="et_pb_row et_pb_row_2"><div class="et_pb_column et_pb_column_4_4 et_pb_column_6 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_button_module_wrapper et_pb_button_0_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_0 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/sspc-research-discover-our-impacts/" data-icon="5">View all research projects </a></div></div></div></div><div class="et_pb_section et_pb_section_2 home-first-section et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_3 et_animated et_pb_equal_columns et_pb_gutters2"><div class="et_pb_column et_pb_column_1_2 et_pb_column_7 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_blurb et_pb_blurb_6 et_clickable et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_dark"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap"><span class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone et-pb-icon"></span></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Talent</span></h4><div class="et_pb_blurb_description"><p>SSPC nurtures a talent pipeline of high calibre scientists and engineers for the sector, through our internal PhD training programme and various CPD mechanisms available to our industry partners. SSPC offers a unique proposition through its industry placement programme and 63% of SSPC graduates go on to be employed in industry both nationally and globally.</p></div></div></div></div><div class="et_pb_button_module_wrapper et_pb_button_1_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_1 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/our-people/" data-icon="5">Learn More</a></div></div><div class="et_pb_column et_pb_column_1_2 et_pb_column_8 et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_blurb et_pb_blurb_7 et_clickable et_pb_text_align_left et_pb_blurb_position_top et_pb_bg_layout_dark"><div class="et_pb_blurb_content"><div class="et_pb_main_blurb_image"><span class="et_pb_image_wrap"><span class="et-waypoint et_pb_animation_top et_pb_animation_top_tablet et_pb_animation_top_phone et-pb-icon"></span></span></div><div class="et_pb_blurb_container"><h4 class="et_pb_module_header"><span>Industry</span></h4><div class="et_pb_blurb_description"><p>Since its inception, SSPC has successfully collaborated with over 50 industry partners, composed of indigenous and foreign operations, whose size range from small to multi-national. Collectively, this demonstrates a strong track-record in delivering applied research that enables industry to solve challenges leading to the development of better medicine. SSPC has supported 54 industry projects since 2019.</p></div></div></div></div><div class="et_pb_button_module_wrapper et_pb_button_2_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_2 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/industry/" data-icon="5">Learn More</a></div></div></div></div><div class="et_pb_section et_pb_section_3 et_section_regular" ><div class="et_pb_row et_pb_row_4"><div class="et_pb_column et_pb_column_1_4 et_pb_column_9 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_0 number-counter-plus container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="230" data-bar-bg-color="#B0216F" data-color="#B0216F" data-alpha="0.33"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">Researchers</h3></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_10 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_1 number-counter-millplus container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="450" data-bar-bg-color="#53A3BB" data-color="#53A3BB" data-alpha="0.33"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">Economic Impact since 2013</h3></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_11 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_2 number-counter-plus container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="50" data-bar-bg-color="#ca6742" data-color="#ca6742" data-alpha="1"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">Industry Partners</h3></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_12 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_3 container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="2400" data-bar-bg-color="#29275C" data-color="#29275C" data-alpha="1"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">Jobs created in industry following FDI</h3></div></div></div></div><div class="et_pb_row et_pb_row_5"><div class="et_pb_column et_pb_column_1_4 et_pb_column_13 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_4 number-counter-plus container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="1300" data-bar-bg-color="#29275C" data-color="#29275C" data-alpha="0.33"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">Peer-Reviewed Publications</h3></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_14 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_5 container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="1985" data-bar-bg-color="#CA6742" data-color="#CA6742" data-alpha="1"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">International Co-Authors in 48 countries across 6 continents</h3></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_15 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_6 container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="84" data-bar-bg-color="#53A3BB" data-color="#53A3BB" data-alpha="1"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign">%</span></p></div><h3 class="et_pb_module_header">Transition of Researchers to Industry</h3></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_16 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_circle_counter et_pb_circle_counter_7 container-width-change-notify et_pb_text_align_center et_pb_bg_layout_light et_pb_with_title"><div class="et_pb_circle_counter_inner" data-number-value="2000+" data-bar-bg-color="#B0216F" data-color="#B0216F" data-alpha="1"><div class="percent"><p><span class="percent-value"></span><span class="percent-sign"></span></p></div><h3 class="et_pb_module_header">Education & Public Engagement Activities</h3></div></div></div></div></div><div class="et_pb_section et_pb_section_4 et_section_regular" ><div class="et_pb_row et_pb_row_6"><div class="et_pb_column et_pb_column_4_4 et_pb_column_17 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_center et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Latest News</h1></div></div></div></div><div class="et_pb_row et_pb_row_7 et_animated"><div class="et_pb_column et_pb_column_4_4 et_pb_column_18 et_pb_css_mix_blend_mode_passthrough et-last-child"><div id="home-latest-news-module" class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><div class="wplp_outside wplp_widget_196" style="max-width:100%;"><div id="wplp_widget_196" class="wplp_widget_smooth-effect wplp_container vertical defaultflexslide smooth-effect pro cols3" data-post="196" style="" data-max-elts="12" data-per-page="10"><ul class="wplp_listposts slides defaultflexslide" id="smoothcontainer_196" style="" ><li id="wplp_li_196_14245" data-post="14245" class="postno_1 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2025/03/john-alexander.png')"><div class="insideframe"><div id="wplp_box_top_196_14245" class="wpcu-front-box top " ><a href="https://sspc.ie/sspc-appoints-john-alexander-as-new-governance-committee-chair/" ><span class="category">Business / Research</span><span class="date">March 7, 2025</span></a></div><div id="wplp_box_left_196_14245" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/sspc-appoints-john-alexander-as-new-governance-committee-chair/" ></a></div><div id="wplp_box_right_196_14245" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/sspc-appoints-john-alexander-as-new-governance-committee-chair/" ></a></div><div id="wplp_box_bottom_196_14245" class="wpcu-front-box bottom " ><a href="https://sspc.ie/sspc-appoints-john-alexander-as-new-governance-committee-chair/" ><span class="title"><span style="height:2.7em" class="line_limit">SSPC appoints John Alexander as new governance committee chair</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">SSPC, the Research Ireland Centre for Pharmaceuticals is pleased to announce the appointment of John Alexander, as the new Governance Committee chair. John brings a wealth of experience in management and governance, having previously enjoyed a diverse group of roles in Industry and has worked as Global Head of Novartis Country Quality as well as Novartis Quality Lead. He spent 5 years working for Sandoz (Germany) as Heads of Quality Assurance – Commercial Affiliates, Third Party QA and BioPharmaceuticals QA and 8 years as site head at Novartis in Ringaskiddy. John has a master’s degree in Bacteriology from Queen’s University Belfast and is currently supporting RCSI in Dublin regarding their Advanced Therapeutic Technologies undergraduate degree. Commenting on his appointment John said, “As the new Governance Chair of SSPC, I am incredibly proud to be part of an internationally recognised Centre of Excellence. SSPC is particularly committed to breaking down traditional boundaries across academia and promoting new research and I am looking forward to being a part of overseeing the centre’s governance framework and promoting best practices in research integrity.” The position marks the departure of previous chair Maeve Devlin, (ex Novartis), who brought over 40 years of experience in the pharmaceutical industry to the role. Professor Damien Thompson, added: “We are thrilled to welcome John to our team, he will be instrumental in guiding our governance efforts and supporting our researchers and SSPC in achieving excellence. We wish Maeve all the best and thank her for her outstanding support and dedication over the past six years, having upheld the highest standards of governance and contributed significantly to the centre’s ongoing success.” SSPC has unprecedented links with the biggest names in the pharma industry, collaborating with >50 partners, helping Ireland to punch well above its weight in attracting big players to our shores. SSPC supports a wide range of research projects, from molecule development to manufacturing processes. SSPC’s research impacts society by improving and advancing the sustainable production and the availability of medicines globally....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14226" data-post="14226" class="postno_2 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2025/02/bpci_impact_awards_launch.png')"><div class="insideframe"><div id="wplp_box_top_196_14226" class="wpcu-front-box top " ><a href="https://sspc.ie/biopharmachem-ireland-launches-2025-impact-awards/" ><span class="category">Business</span><span class="date">February 12, 2025</span></a></div><div id="wplp_box_left_196_14226" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/biopharmachem-ireland-launches-2025-impact-awards/" ></a></div><div id="wplp_box_right_196_14226" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/biopharmachem-ireland-launches-2025-impact-awards/" ></a></div><div id="wplp_box_bottom_196_14226" class="wpcu-front-box bottom " ><a href="https://sspc.ie/biopharmachem-ireland-launches-2025-impact-awards/" ><span class="title"><span style="height:2.7em" class="line_limit">BioPharmaChem Ireland Launches 2025 Impact Awards</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">BioPharmaChem Ireland (BPCI), the Ibec group that represents the biopharmaceutical and chemical sectors, today announced the launch of its inaugural Impact Awards 2025, which will be held as part of the BioPharmaChem Impact 2025 conference on 8 May at Kilashee House Hotel, Co. Kildare. The theme of this year’s conference is ‘Realising the Potential of the Ecosystem’. Sinead Keogh, Director of BioPharmaChem Ireland said: “The biopharmaceutical and chemical industries have had a huge impact on Ireland’s economic success in recent years. Almost 50,000 people are now employed directly in the sector in Ireland, including 25% of all PhDs in Ireland, across over 90 sites, producing over €100bn in exports annually. This rises to over 80,000 when indirect employment is factored in. “This year’s Impact conference is about exploring the incredible potential of the biopharmachem ecosystem and celebrating the people and organisations making this sector such a success. The inaugural Impact Awards 2025 will shine a spotlight on their achievements as well as provide a platform for leaders to share best practice at a time of increasing global competition for investment in the sector.” The Impact Awards will honour excellence across seven distinct categories: BioPharmaChem Company of the Year Award: Honouring the standout company that has made significant contributions to the sector. Best Process Innovation/Digitalisation of the Year Award: Recognising groundbreaking advancements in processes and digital technologies. Best Talent Strategy of the Year Award: Celebrating exceptional strategies in talent acquisition and development. BioPharmaChem Partner/Supplier of the Year Award: Acknowledging excellence in partnership and supply chain contributions. Collaboration in BioPharmaChem Award: Highlighting successful collaborations that have driven innovation and growth. Emerging BioPharmaChem Company of the Year Award: Recognising fledgling companies that show exceptional promise in the industry. Sustainable BioPharmaChem Company of the Year Award: Celebrating efforts towards sustainability and responsible practices in biopharmchem. Johanna McLoughlin, EY Ireland Consulting Partner and Life Sciences Lead said: “EY is proud to be a platinum sponsor for BioPharmaChem Impact 25. Collaboration is essential for the future success of the biopharma sector in Ireland and unlocking the industry’s full potential. Highlighting best practice and exemplary achievements in the industry in the areas of innovation, technology and talent allows us to learn from each other, and better position ourselves, collectively, to create the opportunities and manage the challenges that lie ahead. BioPharmaChem Ireland has done an outstanding job bringing together a brilliant event that fosters this spirit of collaboration.” Jamie Guidera, Chief Operations Officer, SSPC, the Research Ireland Centre for Pharmaceuticals, commented: “Ireland’s biopharma and chemical sectors are at the forefront of global innovation, consistently delivering breakthrough therapies and advanced manufacturing solutions. A testament to the power of collaboration between industry, academia, and government, this vibrant RD&I ecosystem generates significant economic growth and high-value employment opportunities for Ireland. The Impact 2025 Awards provide a vital platform to recognize the organizations and individuals who are driving this success, fostering further collaboration, and securing Ireland’s position as a leader in this critical global sector. We are proud to partner with BPCI on this awards programme.” BPCI are immensely grateful to our sponsors. They include platinum sponsors; EY and SSPC. Gold sponsors; Brightbeam, Camida, Chemco, DHL Supply Chain and Innopharma and silver sponsors, BioPharmaChem Skillnet, BioPharmaChem Ireland Apprenticeships, Enterprise Ireland, IDA Ireland, Indaver, Micro-Bio, Orion GXP Consulting and WuXi Biologics. More information about the awards and how to apply available here: bcpimpact.ie and the deadline to apply for the awards is 14 March. Pictured L-R are platinum sponsors Jamie Guidera, Chief Operations Officer, SSPC, the Research Ireland Centre for Pharmaceuticals, event host, Sinead Keogh, Director of BioPharmaChem Ireland, platinum sponsor Johanna McLoughlin, EY Ireland Consulting Partner and Life Sciences Lead....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14208" data-post="14208" class="postno_3 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2025/02/andrew_abstract_2025.png')"><div class="insideframe"><div id="wplp_box_top_196_14208" class="wpcu-front-box top " ><a href="https://sspc.ie/scientists-at-dcu-develop-novel-copper-based-dna-cleaving-agent-using-click-chemistry/" ><span class="category">Research</span><span class="date">February 4, 2025</span></a></div><div id="wplp_box_left_196_14208" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/scientists-at-dcu-develop-novel-copper-based-dna-cleaving-agent-using-click-chemistry/" ></a></div><div id="wplp_box_right_196_14208" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/scientists-at-dcu-develop-novel-copper-based-dna-cleaving-agent-using-click-chemistry/" ></a></div><div id="wplp_box_bottom_196_14208" class="wpcu-front-box bottom " ><a href="https://sspc.ie/scientists-at-dcu-develop-novel-copper-based-dna-cleaving-agent-using-click-chemistry/" ><span class="title"><span style="height:2.7em" class="line_limit">Scientists at DCU Develop Novel Copper-Based DNA-Cleaving Agent Using Click Chemistry</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">The Kellett Group at Dublin City University (DCU), have developed a new copper-based compound that can selectively bind to and damage DNA. This research contributes to the ongoing search for innovative approaches to targeting genetic material, which could have applications in cancer research. Using a versatile chemical method known as click chemistry, the team has created a highly efficient system for designing and optimising new DNA-interacting molecules. The compound, Cu₂-BPL-C6, belongs to a class of molecules known as artificial metallo-nucleases (AMNs). These are synthetic compounds designed to mimic the function of natural enzymes that cut DNA. In living organisms, enzymes called nucleases help repair, copy, or break down DNA. Artificial metallo-nucleases achieve similar effects using metal ions, which can generate highly reactive species capable of cleaving DNA strands. Scientists are exploring these compounds as potential tools for studying DNA, developing new therapies, and even targeting cancer cells. Click chemistry is a simple and highly reliable approach used by chemists to quickly and efficiently connect molecular building blocks, much like snapping pieces of a puzzle together. This method allows scientists to create complex molecules in a controlled and predictable way, making it a valuable tool for designing new drugs and biomolecules. Using click chemistry, the DCU researchers were able to precisely construct Cu₂-BPL-C6 to enhance its DNA-targeting properties. Cu₂-BPL-C6 is a dinuclear copper complex designed to induce oxidative DNA damage through two redox-active copper centres linked by a flexible aliphatic spacer. The research team has shown that the compound exhibits site-specific DNA recognition with low micromolar activity, preferentially binding to AT-rich DNA sequences. The binding properties of Cu₂-BPL-C6 were characterised using molecular and biophysical techniques, including circular dichroism spectroscopy, agarose gel electrophoresis, and fluorescence quenching assays. Its oxidative cleavage mechanism was further investigated through in vitro studies involving spin-trapping antioxidants and free radical scavengers, and was shown to damage DNA extracted from peripheral mononuclear blood cells. A copper-free version of the compound was tested in collaboration with the National Cancer Institute (NCI-60) screening programme against a panel of cancer cell lines. The results revealed selective activity against melanoma, breast, colon, and non-small cell lung cancers. In conjunction with this screening, a further study using cancer cell lines demonstrated that the presence of copper(II) ions sensitises lethality in MDA-MB-468, a triple-negative breast cancer cell line. The study highlights the potential of Cu₂-BPL-C6 as a DNA-targeting agent and demonstrates the advantages of click chemistry in the design and optimisation of new metallo-nucleases. The application of this approach in synthetic chemistry is expected to expand, providing new opportunities for the development of DNA-targeted therapeutics. “This latest work shows another leap forward for the SSPC in the development of advanced therapeutics. Here, the Kellett group demonstrated very elegant and efficient synthesis of copper-based drugs to target DNA in cancer cells. We keep pushing forward as a transdisciplinary Centre, co-developing drug synthesis, formulation and process engineering platforms to translate a broad range of advanced modalities including these promising copper-based drugs into sustainable patient-centred medicines.” Professor Damien Thompson Link to paper in Nucleic Acids Research: Design and in vitro anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease | Nucleic Acids Research | Oxford Academic Simon Poole, Obed Akwasi Aning, Vickie McKee, Thomas Catley, Aaraby Yoheswaran Nielsen, Helge Thisgaard, Pegah Johansson, Georgia Menounou, Joseph Hennessy, Creina Slator, Alex Gibney, Alice Pyne, Bríonna McGorman, Fredrik Westerlund, Andrew Kellett...</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14164" data-post="14164" class="postno_4 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2024/12/Prf-Pic.jpg')"><div class="insideframe"><div id="wplp_box_top_196_14164" class="wpcu-front-box top " ><a href="https://sspc.ie/md-kamruzzamans-industry-placement-at-sk-biotek/" ><span class="category">Research / Training</span><span class="date">December 20, 2024</span></a></div><div id="wplp_box_left_196_14164" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/md-kamruzzamans-industry-placement-at-sk-biotek/" ></a></div><div id="wplp_box_right_196_14164" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/md-kamruzzamans-industry-placement-at-sk-biotek/" ></a></div><div id="wplp_box_bottom_196_14164" class="wpcu-front-box bottom " ><a href="https://sspc.ie/md-kamruzzamans-industry-placement-at-sk-biotek/" ><span class="title"><span style="height:2.7em" class="line_limit">Md Kamruzzaman’s industry placement at SK Biotek</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">Read about Md Kamruzzaman experience on an SSPC placement at SK Biotek: I am Md Kamruzzaman, a fourth-year PhD researcher at the Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC) at South East Technological University (SETU), Waterford. One of the major challenges in pharmaceutical development is the poor aqueous solubility of many compounds, which reduces their dissolution and absorption in the body-a research challenge extensively investigated by the SSPC medicine theme. Under the supervision of Niall O’Reilly, Peter McLoughlin, and Helen Cathcart, my research focuses on formulating high drug-loading amorphous drug systems to improve the solubility of poorly water-soluble drugs. However, amorphous materials are not very stable on their own, which poses another challenge. My work involves developing formulation strategies to maintain their amorphous state until they reach the patient. I recently completed a three-month industry placement in the Research and Development at SK Biotek, Swords, Ireland. This experience provided me with a practical understanding of the operational procedures in the pharmaceutical industry in Ireland. It was a valuable experience that provided insights into the pharmaceutical industry’s research and development activities. This opportunity allowed me to enhance my technical skills in crystallization, material characterization, particle engineering, and the implementation of process analytical technology. The placement provided a valuable opportunity to explore work in the industry, particularly within a GMP facility. My activities were based in processes R&D, which is part of the Research and Development department. It was a great learning experience to observe these professionals and understand the process and instruments they used to synthesis of drug substance and intermediates. Beyond the technical knowledge, the placement also emphasized the significance of soft skills, such as team work, time management, communication and professional conduct. These skills are essential for success, whether in academia or industry, and the placement gave me the chance to further refine them. This placement was an excellent opportunity to gain practical experience in the pharmaceutical industry. It not only helped me understand how my skills fit into a professional career but also allowed me to develop and update skills that will be crucial when transitioning from academia. Overall, this experience provided me with a solid understanding of the work involved in the pharmaceutical industry, the potential roles for PhD graduates and the expectations they need to meet. It was particularly inspiring to connect with SSPC alumni and hear about their successful transitions from academia to industry. Their stories were full of valuable guidance and insights, which I found incredibly motivating. I am grateful to SSPC for the opportunity and support during my PhD, which has allowed me to take full advantage of career development opportunities and connect with industry professionals....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14139" data-post="14139" class="postno_5 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2024/12/Pic_MAB.png')"><div class="insideframe"><div id="wplp_box_top_196_14139" class="wpcu-front-box top " ><a href="https://sspc.ie/mohamad-baassiri-sspc-placement-at-apc-ltd/" ><span class="category">Research / Training</span><span class="date">December 16, 2024</span></a></div><div id="wplp_box_left_196_14139" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/mohamad-baassiri-sspc-placement-at-apc-ltd/" ></a></div><div id="wplp_box_right_196_14139" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/mohamad-baassiri-sspc-placement-at-apc-ltd/" ></a></div><div id="wplp_box_bottom_196_14139" class="wpcu-front-box bottom " ><a href="https://sspc.ie/mohamad-baassiri-sspc-placement-at-apc-ltd/" ><span class="title"><span style="height:2.7em" class="line_limit">Mohamad Baassiri SSPC placement at APC Ltd.</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">Mohamad Baassiri is a Mechanical Engineer and a PhD candidate at SSPC, Bernal Institute, University of Limerick, Ireland. Read about his SSPC industry placement experience: My background is on thermal and fluid sciences, and my research focuses on the digitization of the pharmaceutical manufacturing sector through state-of-the-art modelling techniques as well as experimentation. The purpose of my research is to develop effective computational fluid dynamics models to simulate the high-pressure atomization applications involved in pharmaceutical manufacturing, making the process more sustainable. By creating new efficient digital twins for the manufacturing systems, a significant part of the testing process can be carried out through modelling while minimizing on-site experimentation. This is believed to help bring down the cost of commercializing new drug products, which currently costs 1-2 billion USD per product and more than a decade of product development and testing. I did my placement at the Applied Process Company (APC) in Dublin, Ireland where I worked as a process development engineer in the digitization team. My duties included carrying out in-silico optimization studies for clients from the pharmaceutical manufacturing sector. I had the chance to work on 3 commercial projects for top pharmaceutical manufacturers in Ireland, in addition to 1 internal project that involved data analytics of the company’s carbon footprint data. Since the placement involved simulating applications different than the application I’m studying at UL, I was able to discover new potential of the modelling tools and apply this to simulations needed for my PhD studies. Additionally, the pace of the commercial projects I was involved in was faster than that of an academic PhD project. This was an eye-opener on skills I need to further develop in order to keep up with such a fast pace of deliverables. At APC, employees are normally involved in the strategic plans and are made aware of the business plan through meetings and communications. Exposure to this kind of business environment was essential to me as it satisfied my curiosity about the mechanisms of starting and running companies in a competitive market as that of Ireland. Overall, this experience was a valuable addition to my career, and it certainly encouraged me to consider a job in the industry. I highly recommend PhD candidates to engage themselves in this experience as it is an excellent opportunity to discover the market. That said, exerting the best of efforts while on placement will further strengthen your profile and boost your employability....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14102" data-post="14102" class="postno_6 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2024/11/rob_maynooth_bandages.jpg')"><div class="insideframe"><div id="wplp_box_top_196_14102" class="wpcu-front-box top " ><a href="https://sspc.ie/maynooth-university-leads-study-on-spray-on-wash-off-bandages-for-painful-eb-condition/" ><span class="category">Business / Research</span><span class="date">November 18, 2024</span></a></div><div id="wplp_box_left_196_14102" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/maynooth-university-leads-study-on-spray-on-wash-off-bandages-for-painful-eb-condition/" ></a></div><div id="wplp_box_right_196_14102" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/maynooth-university-leads-study-on-spray-on-wash-off-bandages-for-painful-eb-condition/" ></a></div><div id="wplp_box_bottom_196_14102" class="wpcu-front-box bottom " ><a href="https://sspc.ie/maynooth-university-leads-study-on-spray-on-wash-off-bandages-for-painful-eb-condition/" ><span class="title"><span style="height:2.7em" class="line_limit">Maynooth University leads study on ‘spray on, wash off’ bandages for painful EB condition</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">Irish research into new bandaging aims to ease the agony experienced by those living with genetic skin condition Epidermolysis Bullosa (EB). Scientists at Maynooth University, Co Kildare, are leading research into whether ‘spray on, wash off’ bandages will be a viable alternative to those currently used, which can cause severe pain when applied and removed. EB, endured by 300 people in Ireland, is caused by the absence of proteins between the skin layers, meaning the skin becomes ultra fragile and blisters at the mildest touch. In severe cases, such as Recessive Dystrophic EB, bandage changes to protect wounds and prevent blister infection are required every day and can last three to four hours at a time. The two-year study by Maynooth University, which began on October 1, received co-funding of almost €113,000 from Debra, the national charity supporting those living with EB, and the Irish Research Council (IRC). Its key aim will be to enable scientists to develop a prototype, with the hope of allowing non-abrasive bandages to be sprayed onto the skin. By placing them under cold water, it is hoped that they will then melt away and be removed painlessly. “Bandage changes are a particularly excruciating element of this condition and research of this nature has the potential to make a real difference for people living with EB,” said Jimmy Fearon, CEO of Debra. “We hope its outcome might contribute to improved quality of life for those living with EB in Ireland, and beyond.” “The aim, ultimately, is not to cause further damage to the skin,” said Dr Robert Elmes, Associate Professor at the Department of Chemistry at Maynooth University and a Funded Investigator at SSPC, Research Ireland Centre for Pharmaceuticals. “We use supramolecular chemistry as the basis to the research, studying how molecules interact with each other and how we can predict how they will separate from each other as they cool. “This is an excellent example of a fundamental area of chemical science having a potentially life-changing impact on the everyday lives of people with EB. Pricing for the bandages is not expected to be out of reach of those living with EB as the materials used are widely available and completely harmless to the skin. The work will be carried out by Dr Hilal Kirpik, of Maynooth University’s Department of Chemistry, who is passionate about the real world impact of chemical research. “By the end of the project, we hope to have a prototype that people can take home and administer themselves without the need for painful bandage removal,” said Dr Elmes, research project supervisor. EB was recently highlighted by Patient Ambassador for Debra, Emma Fogarty, who suffers from this painful condition, and Irish actor Colin Farrell who both participated in the Dublin City Marathon to highlight the condition. For more information on EB, see: debra.ie....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14094" data-post="14094" class="postno_7 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2024/11/group_pharma_awards-scaled.jpg')"><div class="insideframe"><div id="wplp_box_top_196_14094" class="wpcu-front-box top " ><a href="https://sspc.ie/sspc-celebrates-major-success-at-irish-pharma-industry-awards/" ><span class="category">Awards / Business / Research</span><span class="date">November 5, 2024</span></a></div><div id="wplp_box_left_196_14094" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/sspc-celebrates-major-success-at-irish-pharma-industry-awards/" ></a></div><div id="wplp_box_right_196_14094" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/sspc-celebrates-major-success-at-irish-pharma-industry-awards/" ></a></div><div id="wplp_box_bottom_196_14094" class="wpcu-front-box bottom " ><a href="https://sspc.ie/sspc-celebrates-major-success-at-irish-pharma-industry-awards/" ><span class="title"><span style="height:2.7em" class="line_limit">SSPC celebrates major success at Irish Pharma Industry Awards</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">The Irish Pharma Industry Awards: Celebrating Excellence in Ireland’s Thriving Pharmaceutical Sector SSPC Research Ireland Centre for Pharmaceuticals, hosted at the University of Limerick (UL), has once again demonstrated its unwavering commitment to excellence in the field of pharmaceutical research and development. This year, SSPC won big at the Irish Pharma Industry Awards, in the categories Research Centre of the Year and Partnership Alliance of the Year. SSPC’s collaboration incorporates end-to-end research capabilities in both small molecule and biologics drug substance and drug product development & manufacture, with 50+ industrial partners engaging from around the globe, driven by SSPC’s excellence in fundamental science, talent development and access to world-class research expertise & infrastructure. The pharmaceutical industry plays a pivotal role in Ireland’s economy, with a long-standing history of excellence and innovation. In recognition of this, the Irish Pharma Industry Awards serve as a platform to celebrate and honour the achievements and innovations within the Irish pharmaceutical sector. Prof. Damien Thompson, SSPC Scientific Director, who was at the event, said: “At the forefront of cutting-edge scientific breakthroughs and innovation in the biopharmaceutical industry, SSPC has proven itself as a leader in driving advancements that significantly impact this industry. The Centre’s dedication to pushing boundaries and exploring new frontiers have earned it well-deserved accolades at this prestigious event.” UL Vice President Research Professor Norelee Kennedy said: “These awards are not only a recognition of SSPC’s achievements, but a testament to the unwavering commitment to improving lives through science. We are delighted that University of Limerick is part of such a significant research centre, shining a spotlight on the remarkable accomplishments and innovations that shape the future of healthcare and pharmaceuticals, not only in Ireland but around the world.” Dr Sinead Keogh, Head of Sectors and Director, BioPharmaChem at Ibec, added: “The availability of a highly skilled workforce has been pivotal in Ireland’s ability to leverage the opportunities presented by the global growth of the biopharma sector. SSPC nurtures talent, driving innovation, whilst maintaining economic vitality. These awards are a testament to the exceptional work being done by SSPC and serve as a reminder of the industry’s importance and its dedication to improving the well-being of individuals worldwide.” SSPC has a strong commitment to collaborate with world-leading institutes to foster a culture of knowledge-sharing and accelerated progress in biopharmaceutical research. The Irish Pharma Industry awards provide a unique opportunity to commend outstanding contributions made by organisations that are transforming the landscape of pharmaceuticals. Being recognised among industry peers is a testament to SSPC’s unwavering commitment to excellence and its impact on shaping the future of medicines and health. Picture caption: This year, SSPC Research Ireland Centre for Pharmaceuticals won two awards at the recent Irish Pharma Industry Awards, in the categories Research Centre of the Year and the Partnership Alliance of the Year. Pictured receiving Pharma Research Centre of the Year award, from left to right, Louise O’Neill, SSPC Communications Manager, Professor Damien Thompson, SSPC Scientific Director, eurofins representative, Aisling Arthur, SSPC Industry Engagement, Associate Professor Finbarr O’Sullivan, and Associate Professor Paula Meleady, Dublin City University....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14086" data-post="14086" class="postno_8 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2024/10/sspc_nibrt_image_2.jpg')"><div class="insideframe"><div id="wplp_box_top_196_14086" class="wpcu-front-box top " ><a href="https://sspc.ie/nibrt-to-join-sspc-strengthening-collaborative-ties-to-drive-innovation-in-the-biopharma-sector/" ><span class="category">Business / Research</span><span class="date">October 25, 2024</span></a></div><div id="wplp_box_left_196_14086" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/nibrt-to-join-sspc-strengthening-collaborative-ties-to-drive-innovation-in-the-biopharma-sector/" ></a></div><div id="wplp_box_right_196_14086" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/nibrt-to-join-sspc-strengthening-collaborative-ties-to-drive-innovation-in-the-biopharma-sector/" ></a></div><div id="wplp_box_bottom_196_14086" class="wpcu-front-box bottom " ><a href="https://sspc.ie/nibrt-to-join-sspc-strengthening-collaborative-ties-to-drive-innovation-in-the-biopharma-sector/" ><span class="title"><span style="height:2.7em" class="line_limit">NIBRT to join SSPC strengthening collaborative ties to drive innovation in the biopharma sector</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">Ireland, October 25, 2024 – SSPC, the Research Ireland Centre for Pharmaceuticals, hosted at University of Limerick, has announced that it is to expand its research capabilities with the addition of The National Institute for Bioprocessing Research and Training (NIBRT) as a partner. This collaboration builds on a strong track record of successful joint initiatives between SSPC and NIBRT, aiming to further advance the development of innovative technologies that address critical industry challenges. SSPC has a strong commitment to collaborate with world-leading institutes to foster a culture of knowledge-sharing and accelerated progress in pharmaceutical and biopharmaceutical research. With over 80 investigators, SSPC has assembled scientists and engineers to work collaboratively to provide innovations that have the potential to benefit humanity for years to come. With this important step, SSPC and NIBRT are building on a long history of partnership to address ambitious research challenges. Notable examples of recent collaborations, which demonstrate the diversity of links between the two organisations and showcase the range of expertise being shared, include: The Research Ireland-funded Advanced Biopharmaceutical Technologies Spokes Project, in partnership with seven major biopharma companies and involving NIBRT Principal Investigators (PIs) Prof. Niall Barron and Assoc. Prof. Jonathan Bones. The topic, extractables and leachables, is of high relevance to the pharmaceutical industry today due to their potential impact on drug safety and efficacy. Prof. Steven Ferguson is both a NIBRT and SSPC Co-Principal Investigator, where his manufacturing theme is strongly aligned to industry with a focus on enabling a disruptive change in the manufacture of drug substances and drug products. NIBRT PIs Prof. Elizabeth Topp and Prof. Anne Moore are also funded Investigators in SSPC. Leveraging Prof Topp’s expertise and leadership position within the global consortium LyoHub, NIBRT and SSPC have been working together on a training collaboration in formulation and lyophilisation processes. Commenting on the announcement, Prof. Damien Thompson, SSPC Scientific Director, said: “This collaboration represents a key step forward to innovate and deliver life-changing therapies in the (bio)pharma space in Ireland. By combining our expertise and resources, we are poised to advance science and talent. Ensuring that Ireland remains at the forefront of global pharmaceutical research and development is essential, and we are delighted to see such a high calibre partner come on board.” “We are delighted to deepen our partnership with SSPC, a leading research centre that shares our commitment to advancing the pharmaceutical and biopharmaceutical sectors by pulling together excellent researchers and research groups from across Ireland’s research institutes towards a common objective”, commented Dr Darrin Morrissey, NIBRT CEO. “This alliance allows us to leverage each other’s strengths, accelerating innovation and providing even greater support to industry as we work together to address some of the sector’s most complex challenges.” The partnership marks an exciting step forward. Building on an already-established relationship, NIBRT’s membership of SSPC will significantly enhance both organisations’ ability to achieve their strategic goals. This alliance will unlock new opportunities by combining NIBRT’s deep expertise in biopharmaceutical manufacturing research, state-of-the-art research infrastructure and equipment, with SSPC’s cutting-edge pharmaceutical research, offering access to extensive specialist resources, infrastructure, and talent. Photo caption NIBRT to Join SSPC, Strengthening Collaborative Ties to Drive Innovation in the Biopharma Sector. This collaboration builds on a strong track record of successful joint initiatives between SSPC and NIBRT, aiming to further advance the development of innovative technologies that address critical industry challenges. Pictured at the recent announcement were (left-right): Dr Sinéad O’Doherty, SSPC COO (interim), Dr Darrin Morrissey, NIBRT CEO, Prof. Damien Thompson, SSPC Scientific Director, and Killian O’Driscoll. NIBRT CCO....</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14083" data-post="14083" class="postno_9 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/plugins/wp-latest-posts/img/default-image-fpnp.png')"><div class="insideframe"><div id="wplp_box_top_196_14083" class="wpcu-front-box top " ><a href="https://sspc.ie/focus-on-research-with-prof-michael-vynnycky/" ><span class="category">News</span><span class="date">October 24, 2024</span></a></div><div id="wplp_box_left_196_14083" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/focus-on-research-with-prof-michael-vynnycky/" ></a></div><div id="wplp_box_right_196_14083" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/focus-on-research-with-prof-michael-vynnycky/" ></a></div><div id="wplp_box_bottom_196_14083" class="wpcu-front-box bottom " ><a href="https://sspc.ie/focus-on-research-with-prof-michael-vynnycky/" ><span class="title"><span style="height:2.7em" class="line_limit">Focus on Research with Prof Michael Vynnycky</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">Prof Michael Vynnycky is a professor of applied mathematics in the Dept of Maths & Statistics at the University of Limerick’s Faculty of Science & Engineering. In this interview he discusses his role in a collaboration between SSPC, The Applications Consortium for Science and Industry (MACSI), and Varda Space Industries that could change our understanding of how pharmaceuticals can be manufactured in space. Focus on Research: Prof Michael Vynnycky...</span></span><span class="read-more">Read more...</span></a></div></div></li><li id="wplp_li_196_14078" data-post="14078" class="postno_10 smooth-effect li-item-id" style="background-image:url('https://sspc.ie/wp-content/uploads/2024/10/group_Boston_Scientific.jpg')"><div class="insideframe"><div id="wplp_box_top_196_14078" class="wpcu-front-box top " ><a href="https://sspc.ie/sspc-process-engineering-day-hosted-at-boston-scientific-cork/" ><span class="category">Business / Research</span><span class="date">October 24, 2024</span></a></div><div id="wplp_box_left_196_14078" class="wpcu-front-box left wpcu-custom-position" ><a href="https://sspc.ie/sspc-process-engineering-day-hosted-at-boston-scientific-cork/" ></a></div><div id="wplp_box_right_196_14078" class="wpcu-front-box right wpcu-custom-position" ><a href="https://sspc.ie/sspc-process-engineering-day-hosted-at-boston-scientific-cork/" ></a></div><div id="wplp_box_bottom_196_14078" class="wpcu-front-box bottom " ><a href="https://sspc.ie/sspc-process-engineering-day-hosted-at-boston-scientific-cork/" ><span class="title"><span style="height:2.7em" class="line_limit">SSPC Process Engineering Day hosted at Boston Scientific, Cork</span></span><span class="text"><span style="max-height:5.6em" class="line_limit">The SSPC Process Engineering Knowledge Day held on Wednesday, October 23rd, hosted by Boston Scientific, Cork, featuring an exciting mix of talks from our industry partners, Anthony Hannan, Operations Manager, Boston Scientific and Gearóid Markey, Senior Process Development Engineer, Selio Medical. A new Horizon for Intradermal Drug Delivery with Dr Waleed Faisel of Array Patch and academic presentations with Prof. Abina Crean, University College Cork (UCC) and Prof. Vivek, Ranade, University of Limerick (UL). The presentations touched on different aspects of Process Engineering such as Continuous Manufacturing, Process Intensification, Process Modelling and PAT Technologies. A big thank you to our hosts Boston Scientific, Cork, in particular, Phil Dorgan, Joe Devlin, Conor O’Sullivan, and Gary Bell. Also, our Thesis in 3 Minutes and presentations by our SSPC Early Career Researchers: Milton Assuncao, UL, Using gravity to control drug polymorphism in batch crystallization Nancy Moore, UCC, Point of Care Manufacture: Analytical Approaches to Assuring Product Quality Aaron McCormack, University of Galway, New applications of carbohydrates as chiral auxiliaries and novel compound generation via stereoselective azide-alkene cycloaddition, batch vs flow chemistry Ahmed Metawea, UL, Investigation of the capability of continuous Manufacturing techniques for the synthesis of metal organic framework (MOF) Saikat Bhowmick, UL, Experimental Study of Liquid Velocity Characteristics at the Wall Layer of the Limerick Bubble Rig Githin Zachariah, UL, Embedding DNS periodic boxes in Large Eddy Simulations Rese Nethraa Kannan, University College Dublin (UCD), Beyond First-Principles: Harnessing Time-Series Data for Improved Process Modelling and Control Vaishnavi Honovar, UL, Continuous Anti-solvent Crystallization with a crystallizer without moving parts Laura Foley, UL, Investigating the effects of spray dryer process parameters on the physiochemical properties of pharmaceuticals and biopharmaceuticals Innovative process engineering makes manufacturing cost-effective, sustainable and responsive. SSPC teams work to develop fundamental scientific understanding underpinning process engineering applications to enable advances beyond the current state of the art. Our key research focus is on process intensification and continuous manufacturing, including the development of modular manufacturing platforms. The advances in these areas are facilitated by multi-scale modelling of multiphase flows, materials and processes. Part 1 of our spotlight on process engineering shares some exciting recent breakthroughs. Link to SSPC Process Engineering Spotlight: https://sspc.ie/wp-content/uploads/2024/08/Process-Eng.-Spotlight.pdf...</span></span><span class="read-more">Read more...</span></a></div></div></li></ul></div></div></div></div></div></div><div class="et_pb_row et_pb_row_8"><div class="et_pb_column et_pb_column_4_4 et_pb_column_19 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_center et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>SSPC News Updates</h1></div></div><div id="#research-intro-text-module" class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_center et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>View or download our latest news and research outputs.</p></div></div></div></div><div class="et_pb_row et_pb_row_9"><div class="et_pb_column et_pb_column_1_3 et_pb_column_20 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module dsm_icon_list dsm_icon_list_0"><div class="et_pb_module_inner"><ul class="dsm_icon_list_items dsm_icon_list_ltr_direction dsm_icon_list_layout_vertical"><li class="dsm_icon_list_child dsm_icon_list_child_0 et_pb_section_video_on_hover"> <a href="https://sspc.ie/sspc-news-update-2023/"><span class="dsm_icon_list_wrapper"><span class="dsm_icon_list_icon"></span></span><span class="dsm_icon_list_text">SSPC 2023 Research Outputs</span></a></li><li class="dsm_icon_list_child dsm_icon_list_child_1 et_pb_section_video_on_hover"> <a href="https://sspc.ie/sspc-news-update-q3-2023/"><span class="dsm_icon_list_wrapper"><span class="dsm_icon_list_icon">i</span></span><span class="dsm_icon_list_text">SSPC News Update Q3 2023</span></a></li></ul></div></div></div><div class="et_pb_column et_pb_column_1_3 et_pb_column_21 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module dsm_icon_list dsm_icon_list_1"><div class="et_pb_module_inner"><ul class="dsm_icon_list_items dsm_icon_list_ltr_direction dsm_icon_list_layout_vertical"><li class="dsm_icon_list_child dsm_icon_list_child_2 et_pb_section_video_on_hover"> <a href="https://sspc.ie/sspc-news-update-q2-2023/"><span class="dsm_icon_list_wrapper"><span class="dsm_icon_list_icon">i</span></span><span class="dsm_icon_list_text">SSPC News Update Q2 2023</span></a></li><li class="dsm_icon_list_child dsm_icon_list_child_3 et_pb_section_video_on_hover"> <a href="https://sspc.ie/sspc-newsletter-march-2023/"><span class="dsm_icon_list_wrapper"><span class="dsm_icon_list_icon">i</span></span><span class="dsm_icon_list_text">SSPC News Update Q1 2023</span></a></li></ul></div></div></div><div class="et_pb_column et_pb_column_1_3 et_pb_column_22 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module dsm_icon_list dsm_icon_list_2"><div class="et_pb_module_inner"><ul class="dsm_icon_list_items dsm_icon_list_ltr_direction dsm_icon_list_layout_vertical"><li class="dsm_icon_list_child dsm_icon_list_child_4 et_pb_section_video_on_hover"> <a href="https://sspc.ie/sspc-2022-review/"><span class="dsm_icon_list_wrapper"><span class="dsm_icon_list_icon"></span></span><span class="dsm_icon_list_text">SSPC 2022 Research Outputs</span></a></li><li class="dsm_icon_list_child dsm_icon_list_child_5"> <a href="https://sspc.ie/sspc-news-update-q1-2024/"><span class="dsm_icon_list_wrapper"><span class="dsm_icon_list_icon">i</span></span><span class="dsm_icon_list_text">SSPC News Update Q1 2024</span></a></li></ul></div></div></div></div></div><div id="home-research-areas" class="et_pb_section et_pb_section_5 et_pb_with_background et_section_regular section_has_divider et_pb_top_divider" ><div class="et_pb_top_inside_divider et-no-transition"></div><div class="et_pb_row et_pb_row_10"><div class="et_pb_column et_pb_column_4_4 et_pb_column_23 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_4 et_pb_text_align_center et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>SSPC’s world-leading Research Programme</h1></div></div><div id="#research-intro-text-module" class="et_pb_module et_pb_text et_pb_text_5 et_pb_text_align_center et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Our unique and innovative culture of collaboration is helping the global pharmaceutical and biopharmaceutical industry to develop more environmentally sustainable methods for drug manufacturing; to increase the range of medicines available to the public and to reduce drug manufacturing costs. SSPC’s advanced research programme extends from <a href="https://sspc.ie/our-research/molecule/"><strong>Molecule</strong></a>, <a href="https://sspc.ie/our-research/materials/"><strong>Materials</strong></a> and <a href="https://sspc.ie/our-research/medicine/"><strong>Medicine</strong></a> into the <a href="https://sspc.ie/our-research/manufacturing/"><strong>Manufacturing</strong></a> and <a href="https://sspc.ie/our-research/modelling/"><strong>Modelling</strong></a> space.</p></div></div></div></div></div><div class="et_pb_section et_pb_section_6 et_section_regular section_has_divider et_pb_top_divider" ><div class="et_pb_top_inside_divider et-no-transition"></div><div class="et_pb_row et_pb_row_11 et_pb_equal_columns et_pb_gutters1"><div class="et_pb_column et_pb_column_1_5 et_pb_column_24 et_animated et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_0"> <a href="https://sspc.ie/our-research/molecule/"><span class="et_pb_image_wrap "><img loading="lazy" decoding="async" width="436" height="146" src="https://sspc.ie/wp-content/uploads/2019/11/Molecule_Home_Heading.png" alt="" title="" srcset="https://sspc.ie/wp-content/uploads/2019/11/Molecule_Home_Heading.png 436w, https://sspc.ie/wp-content/uploads/2019/11/Molecule_Home_Heading-300x100.png 300w" sizes="(max-width: 436px) 100vw, 436px" class="wp-image-107" /></span></a></div><div class="et_pb_module et_pb_text et_pb_text_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>These themes focus on developing new methodologies for the asymmetric synthesis of APIs, molecules & methods for automated & in-flow generation of targeted drug hybrids & new therapeutic agents.</p></div></div><div class="et_pb_button_module_wrapper et_pb_button_3_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_3 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/our-research/molecule/" data-icon="5">Learn More</a></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_25 et_animated et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_1"> <a href="https://sspc.ie/our-research/materials/"><span class="et_pb_image_wrap "><img loading="lazy" decoding="async" width="506" height="163" src="https://sspc.ie/wp-content/uploads/2019/11/Materials_Home_Heading.png" alt="" title="" srcset="https://sspc.ie/wp-content/uploads/2019/11/Materials_Home_Heading.png 506w, https://sspc.ie/wp-content/uploads/2019/11/Materials_Home_Heading-480x155.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 506px, 100vw" class="wp-image-106" /></span></a></div><div class="et_pb_module et_pb_text et_pb_text_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Advancing the understanding of single-component crystalline materials (SCCMs) and, especially, multi-component crystalline materials (MCCMs) in order to enable improved orally delivered drug products.</p></div></div><div class="et_pb_button_module_wrapper et_pb_button_4_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_4 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/our-research/materials/" data-icon="5">Learn More</a></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_26 et_animated et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_2"> <a href="https://sspc.ie/our-research/medicine/"><span class="et_pb_image_wrap "><img loading="lazy" decoding="async" width="400" height="120" src="https://sspc.ie/wp-content/uploads/2022/09/Medicines_Logo.png" alt="" title="Medicines_Logo" srcset="https://sspc.ie/wp-content/uploads/2022/09/Medicines_Logo.png 400w, https://sspc.ie/wp-content/uploads/2022/09/Medicines_Logo-300x90.png 300w" sizes="(max-width: 400px) 100vw, 400px" class="wp-image-11427" /></span></a></div><div class="et_pb_module et_pb_text et_pb_text_8 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Optimising the development, production & use of safe, effective medicines with focus on poorly soluble drugs, personalized, age appropriate medicines & rational formulation approaches with predictive performance.</p></div></div><div class="et_pb_button_module_wrapper et_pb_button_5_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_5 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/our-research/medicine/" data-icon="5">Learn More</a></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_27 et_animated et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_3"> <a href="https://sspc.ie/our-research/manufacturing/"><span class="et_pb_image_wrap "><img loading="lazy" decoding="async" width="626" height="147" src="https://sspc.ie/wp-content/uploads/2019/11/Manufacturing_Home_Heading.png" alt="" title="" srcset="https://sspc.ie/wp-content/uploads/2019/11/Manufacturing_Home_Heading.png 626w, https://sspc.ie/wp-content/uploads/2019/11/Manufacturing_Home_Heading-480x113.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 626px, 100vw" class="wp-image-104" /></span></a></div><div class="et_pb_module et_pb_text et_pb_text_9 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Enabling a disruptive change in manufacture of drug substances & drug products, through the development & implementation of continuous manufacturing, flow chemistry & end-to-end manufacturing methodologies.</p></div></div><div class="et_pb_button_module_wrapper et_pb_button_6_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_6 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/our-research/manufacturing/" data-icon="5">Learn More</a></div></div><div class="et_pb_column et_pb_column_1_5 et_pb_column_28 et_animated et_pb_section_video_on_hover et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_image et_pb_image_4"> <a href="https://sspc.ie/our-research/modelling/"><span class="et_pb_image_wrap "><img loading="lazy" decoding="async" width="526" height="163" src="https://sspc.ie/wp-content/uploads/2019/11/Modelling_Home_Heading.png" alt="" title="" srcset="https://sspc.ie/wp-content/uploads/2019/11/Modelling_Home_Heading.png 526w, https://sspc.ie/wp-content/uploads/2019/11/Modelling_Home_Heading-480x149.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 526px, 100vw" class="wp-image-103" /></span></a></div><div class="et_pb_module et_pb_text et_pb_text_10 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><span>This theme will develop new techniques to design and predict behaviour in silico in order to reduce trial-and-error experimentation. Developing new transformative physical models for broad uptake in drug manufacture.</span></p></div></div><div class="et_pb_button_module_wrapper et_pb_button_7_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_7 home-research-area-buttons et_pb_bg_layout_light" href="https://sspc.ie/our-research/modelling/" data-icon="5">Learn More</a></div></div></div></div></div></div></div></article></div><footer class="et-l et-l--footer"><div class="et_builder_inner_content et_pb_gutters3"><div class="et_pb_section et_pb_section_0_tb_footer global-footer-section et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_0_tb_footer global-footer-main et_pb_equal_columns et_pb_gutters3"><div class="et_pb_column et_pb_column_1_6 et_pb_column_0_tb_footer et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_0_tb_footer"> <span class="et_pb_image_wrap 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et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><a href="https://sspc.ie/privacy-policy/">Privacy Policy</a> | <a href="https://sspc.ie/about-us/cookie-policy/">Cookie Policy</a> | <a href="https://sspc.ie/disclaimer/">Disclaimer</a><a href="https://sspc.ie/disclaimer/"></a></p><p>This site is protected by reCAPTCHA and the Google <a href="https://policies.google.com/privacy">Privacy Policy</a> and <a href="https://policies.google.com/terms">Terms of Service</a> apply.</p></div></div></div><div class="et_pb_column et_pb_column_1_4 et_pb_column_8_tb_footer et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_8_tb_footer global-footer-menu et_pb_text_align_right et_pb_bg_layout_light"><div class="et_pb_text_inner">© Copyright SSPC</div></div></div></div><div class="et_pb_row et_pb_row_3_tb_footer global-footer-bottom et_pb_equal_columns et_pb_gutters3"><div class="et_pb_column et_pb_column_4_4 et_pb_column_9_tb_footer et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_9_tb_footer global-footer-menu et_pb_text_align_center et_pb_bg_layout_light"><div class="et_pb_text_inner"><a href="https://sspc.ie/privacy-policy/">Privacy Policy</a> | <a href="https://sspc.ie/about-us/cookie-policy/">Cookie Policy</a> | <a href="https://sspc.ie/disclaimer/">Disclaimer</a><a href="https://sspc.ie/disclaimer/"></a><br /> © All rights reserved © Copyright SSPC</p><p>This site is protected by reCAPTCHA and the Google <a href="https://policies.google.com/privacy">Privacy Policy</a> and <a href="https://policies.google.com/terms">Terms of Service</a> apply.</div></div></div></div></div></div></footer></div></div></div> <div id="divi-area-10262" class="divi-area-wrap divi-area-wrap-10262 divi-area-wrap-pfizer-conversion-of-chord-length-distribution-to-particle-size-distribution divi-area-type-popup divi-area-pfizer-conversion-of-chord-length-distribution-to-particle-size-distribution" style="display:none;"><div class="et_pb_section et_pb_section_dap_10262_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10262_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10262_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10262_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11484" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10262_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10262_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Conversion of Chord Length Distribution to Particle Size Distribution</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10262_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This project aims to develop systematic methodology to convert Chord Length Distribution data to Particle Size Distribution for enhancing the prediction of oral absorption of weakly basic drugs. The computational models used in this project will assist in the interpretation of data being collected.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10262_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Vivek Ranade, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10262",{position:"center_center",ids:"divi-area-pfizer-conversion-of-chord-length-distribution-to-particle-size-distribution"},"addTrigger",DiviArea)</script>  <div id="divi-area-10313" class="divi-area-wrap divi-area-wrap-10313 divi-area-wrap-clarochem-quantification-of-polymorphs-of-drug-substances divi-area-type-popup divi-area-clarochem-quantification-of-polymorphs-of-drug-substances" style="display:none;"><div class="et_pb_section et_pb_section_dap_10313_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10313_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10313_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10313_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Clarochem.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Clarochem.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Clarochem-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Clarochem-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10278" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10313_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10313_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Quantification of polymorphs of drug substances</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10313_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>The aim of this project was to perform analytical tests to determine the LOD and LOQ for two polymorphs, namely α and β, in an API which is comprised of a third polymorph - kappa (ĸ). This was achieved through experimental work to determine the solid concentration calibration curves using a number of analytical techniques including XRD, DSC and Raman Spectroscopy.</p><p><em>“The project was successful in determining which analytical method could provide effective quantitation of the two polymorphs, and delivered LOD and LOQ determinations for each technique evaluated.”</em></p><p><strong>Brian Keaveny, Plant Director - Clarochem</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10313",{position:"center_center",ids:"divi-area-clarochem-quantification-of-polymorphs-of-drug-substances"},"addTrigger",DiviArea)</script>  <div id="divi-area-10307" class="divi-area-wrap divi-area-wrap-10307 divi-area-wrap-scale-up-systems-cfd-study-on-lab-scale-reactor-systems divi-area-type-popup divi-area-scale-up-systems-cfd-study-on-lab-scale-reactor-systems" style="display:none;"><div class="et_pb_section et_pb_section_dap_10307_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10307_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10307_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10307_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Scale-upSystems.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Scale-upSystems.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Scale-upSystems-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Scale-upSystems-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10269" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10307_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10307_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>CFD study on lab-scale reactor systems</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10307_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Scale-up Systems initiated a CFD study by SSPC on the hydrodynamics of commonly used lab-scale reactor systems under typical operating conditions. Predictions of mixing using traditional chemical engineering relationships become more difficult as the scale of operation decreases below a few litres. This project completed a number of CFD simulations allowing more detailed process characterization and will enable users of Dynochem software to make more accurate predictions when scaling-up or down.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10307_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Harry Van den Akker, Bernal Institute, University of Limerick.</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10307",{position:"center_center",ids:"divi-area-scale-up-systems-cfd-study-on-lab-scale-reactor-systems"},"addTrigger",DiviArea)</script>  <div id="divi-area-10364" class="divi-area-wrap divi-area-wrap-10364 divi-area-wrap-alkermes-detection-and-quantification-of-polymorphs-of-drug-substances divi-area-type-popup divi-area-alkermes-detection-and-quantification-of-polymorphs-of-drug-substances" style="display:none;"><div class="et_pb_section et_pb_section_dap_10364_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10364_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10364_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10364_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Alkermes.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Alkermes.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Alkermes-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Alkermes-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10274" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10364_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10364_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Detection and quantification of polymorphs of drug substances</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10364_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This project addressed the limit of detection and quantification of polymorphs of drug substances (DS) in a fixed-dose combination(FDC) drug-product (DP) on Panalytical Empyrean Series 3. The project extended over a period of 4 months with the post-doctoral researcher working between the Alkermes site in Athlone and the University of Limerick.</p><p>This project also facilitated knowledge sharing and exchange of best practice approaches between the SSPC researcher and Alkermes staff located in both the Irish and US sites.</p><p><strong>Led by Prof. Michael Zaworotko and Dr Rana Sanii, Bernal Institute, University of Limerick.</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10364",{position:"center_center",ids:"divi-area-alkermes-detection-and-quantification-of-polymorphs-of-drug-substances"},"addTrigger",DiviArea)</script>  <div id="divi-area-10371" class="divi-area-wrap divi-area-wrap-10371 divi-area-wrap-apc-mechanistic-modelling-of-a-biologics-development-process divi-area-type-popup divi-area-apc-mechanistic-modelling-of-a-biologics-development-process" style="display:none;"><div class="et_pb_section et_pb_section_dap_10371_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10371_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10371_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10371_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_APC.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_APC.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_APC-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_APC-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11483" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10371_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10371_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Mechanistic Modelling of a biologics development process</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10371_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>APC and SSPC conducted a feasibility study to assess the optimal parameters for the Cation Exchange Chromatography step by Chromatography Mechanistic Modelling, using the GoSilico ChromX® software package. The integration of modelling tools into process development of biologics is an important part of the quality by design approach. Mechanistic modelling ensures time and cost‐efficient process optimization by minimizing experimental work. Consequently, the adoption of modelling tools has increased to support process development, process optimization, process characterization and scale-up phases across the pharmaceutical sector.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10371_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Dr. Ioscani Jimenez Del Val, University College Dublin</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10371",{position:"center_center",ids:"divi-area-apc-mechanistic-modelling-of-a-biologics-development-process"},"addTrigger",DiviArea)</script>  <div id="divi-area-10381" class="divi-area-wrap divi-area-wrap-10381 divi-area-wrap-glantreo-in-vitro-in-vivo-evaluation-of-toxicity-and-efficacy-of-cbd-formulation divi-area-type-popup divi-area-glantreo-in-vitro-in-vivo-evaluation-of-toxicity-and-efficacy-of-cbd-formulation" style="display:none;"><div class="et_pb_section et_pb_section_dap_10381_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10381_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10381_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10381_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Glantreo.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Glantreo.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Glantreo-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Glantreo-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10276" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10381_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10381_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>In Vitro In Vivo evaluation of toxicity and efficacy of CBD formulation</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10381_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This study investigated the impact of CBD formulations with respect to toxicity and bioavailability. The project was a collaboration between DCU and Maynooth University and benefited from the combined expertise and infrastructure to support both in-vitro testing on skin and intestinal cell models and in-vivo testing on larvae to measure the toxicity of compounds and in vivo efficacy.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10381_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>The use of in-vitro cell line allows the study of various molecular pathways. This study uses the established cell lines, Caco-2 and HT-29, as models of the intestinal epithelia.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10381_8 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>In Vivo testing was conducted using Larvae (caterpillars) of Galleria mellonella. The insect immune response is very similar to the innate immune response of mammals and so insects may be used in place of mammals for a wide range of applications and yield results equivalent to those from mammalian testing. Larvae can also be used to study the metabolism of compounds and show similar metabolic process as occur in mammals.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10381_9 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Dr Finbarr O’Sullivan, NICB, Dublin City University and Prof. Kevin Kavanagh, Maynooth University.</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10381",{position:"center_center",ids:"divi-area-glantreo-in-vitro-in-vivo-evaluation-of-toxicity-and-efficacy-of-cbd-formulation"},"addTrigger",DiviArea)</script>  <div id="divi-area-10389" class="divi-area-wrap divi-area-wrap-10389 divi-area-wrap-janssen-effect-of-mesoporous-silica-on-amorphous-solid-dispersions divi-area-type-popup divi-area-janssen-effect-of-mesoporous-silica-on-amorphous-solid-dispersions" style="display:none;"><div class="et_pb_section et_pb_section_dap_10389_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10389_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10389_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10389_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10273" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10389_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10389_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Effect of Mesoporous silica on Amorphous Solid Dispersions</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10389_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>The aim of this project is to determine if mesoporous silica can have a protective effect on Amorphous Solid Dispersions (ASD), and so enhance the physical stability and dissolution performance of such formulations.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10389_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>ASDs are highly useful but physically unstable drug-delivery platforms. Maintaining physical stability over the shelf-life of the product is especially challenging for high drug loaded<br />ASDs and for ASDs containing APIs that are prone to rapid crystallization. Mesoporous silica may be a useful formulation additive for de-risking the ASD platform. Silica materials can preferentially adsorb water and thus may promote physical stability of the ASD, stabilizing it by avoiding plasticization of the ASD.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10389_8 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Anne Marie Healy, Trinity College Dublin.</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10389",{position:"center_center",ids:"divi-area-janssen-effect-of-mesoporous-silica-on-amorphous-solid-dispersions"},"addTrigger",DiviArea)</script>  <div id="divi-area-10395" class="divi-area-wrap divi-area-wrap-10395 divi-area-wrap-zinc-ionophoric-activity divi-area-type-popup divi-area-zinc-ionophoric-activity" style="display:none;"><div class="et_pb_section et_pb_section_dap_10395_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10395_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10395_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10395_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10273" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10395_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10395_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Zinc Ionophoric activity</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10395_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Zinc has emerged as a potentially important factor in the treatment of COVID-19; it appears that increasing intracellular zinc with ionophores can inhibit the replication of the virus within in vitro models.</p><p>The overall goal for the study is to investigate how the putative zinc ionophores counterparts compare. The study focuses on ionophoric mechanisms of transport, cellular growth, cell death mechanisms, zinc uptake and expression of key proteins associated with cellular zinc physiology.</p><p>The study will form the basis for more advanced in-depth studies focusing on particular mechanisms and pathways identified during these initial experiments and to establish a set of ‘design rules’ for effective Zn2+ ionophoric activity.</p><p><strong>Led by Dr Rob Elmes Maynooth University, Dr Finbarr O’Sullivan DCU and Dr Oisin Kavanagh, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10395",{position:"center_center",ids:"divi-area-zinc-ionophoric-activity"},"addTrigger",DiviArea)</script>  <div id="divi-area-10409" class="divi-area-wrap divi-area-wrap-10409 divi-area-wrap-centrifuge-process-modelling divi-area-type-popup divi-area-centrifuge-process-modelling" style="display:none;"><div class="et_pb_section et_pb_section_dap_10409_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10409_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10409_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10409_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Janssen-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10273" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10409_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10409_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Centrifuge process modelling</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10409_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This project will develop a predictive model of the Centrifugation process using machine learning algorithms to process data in order to study the effects of centrifugation and drying on the particle size of the API product. The process will be modelled using a combination of auto-encoder and neuro-fuzzy or deep learning approaches.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10409_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Harry Van Den Akker and Dr. Javad Zeinali, Bernal Institute, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10409",{position:"center_center",ids:"divi-area-centrifuge-process-modelling"},"addTrigger",DiviArea)</script>  <div id="divi-area-10416" class="divi-area-wrap divi-area-wrap-10416 divi-area-wrap-lilly-alternate-catalyst-project divi-area-type-popup divi-area-lilly-alternate-catalyst-project" style="display:none;"><div class="et_pb_section et_pb_section_dap_10416_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10416_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10416_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10416_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Lilly.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Lilly.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Lilly-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_Lilly-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10272" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10416_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10416_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Alternate Catalyst Project</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10416_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This project has a high commercial potential for Lilly. The goal of the project is to determine if an alternate catalyst and/or ligand will lead to an increase in the yield of an isolated product.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10416_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Pat Guiry, University College Dublin</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10416",{position:"center_center",ids:"divi-area-lilly-alternate-catalyst-project"},"addTrigger",DiviArea)</script>  <div id="divi-area-10420" class="divi-area-wrap divi-area-wrap-10420 divi-area-wrap-msd-meso-and-micro-mixing-in-a-static-mixer divi-area-type-popup divi-area-msd-meso-and-micro-mixing-in-a-static-mixer" style="display:none;"><div class="et_pb_section et_pb_section_dap_10420_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10420_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10420_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10420_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10271" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10420_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10420_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Meso- and Micro-Mixing in a Static Mixer</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10420_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This international project team brings together expertise from Merck US, MSD Ballydine and SSPC/UL.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10420_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>The project uses Lattice Boltzmann techniques to study the effect of mixing on yield and selectivity. The goal of this project is to computationally simulate meso-mixing and micro-mixing in a static mixer reactor – where multiple related reactions take place with different reaction rates.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10420_8 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Harry Van Den Akker, Bernal Institute, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10420",{position:"center_center",ids:"divi-area-msd-meso-and-micro-mixing-in-a-static-mixer"},"addTrigger",DiviArea)</script>  <div id="divi-area-10425" class="divi-area-wrap divi-area-wrap-10425 divi-area-wrap-pfizer-continuous-anti-solvent-cavi-crystallization divi-area-type-popup divi-area-pfizer-continuous-anti-solvent-cavi-crystallization" style="display:none;"><div class="et_pb_section et_pb_section_dap_10425_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10425_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10425_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10425_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Pfizer22-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11484" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10425_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10425_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Continuous Anti-solvent Cavi-crystallization</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10425_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This project aims to develop a PhD candidate Continuous Anti-solvent Cavi-crystallisation in partnership with Pfizer and two UL based SFI research Centres namely: SSPC and CONFIRM.</p><p>The goal of the research is to develop a systematic methodology for design, optimisation and scale-up of continuous crystallisers working in combination with hydrodynamic cavitation for realising better control on particle size distribution. The developed insights and computational models will be useful to critically evaluate applications to industrially relevant crystallisations.</p><p>Led by Prof. Vivek Ranade and Prof. Gavin Walker, University of Limerick.</p><p><em>“We are delighted to be partnering with SSPC & Confirm on a Continuous Anti-solvent Cavi-crystallisation PhD project. It will have significant benefits for Pfizer, having applications in future manufacturing, enabling research and upskilling in new areas and engagement between our two centres.”</em></p><p><strong>Dr. Lorna Moynihan, Pfizer</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10425",{position:"center_center",ids:"divi-area-pfizer-continuous-anti-solvent-cavi-crystallization"},"addTrigger",DiviArea)</script>  <div id="divi-area-10431" class="divi-area-wrap divi-area-wrap-10431 divi-area-wrap-sanofi-non-invasive-characterisation-of-lyophilised-biopharmaceuticals divi-area-type-popup divi-area-sanofi-non-invasive-characterisation-of-lyophilised-biopharmaceuticals" style="display:none;"><div class="et_pb_section et_pb_section_dap_10431_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_10431_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_10431_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_10431_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sanofi22.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sanofi22.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sanofi22-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sanofi22-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11487" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_10431_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_10431_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Non-Invasive characterisation of Lyophilised Biopharmaceuticals</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10431_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>This 12 month post-doctoral project addresses commercial challenges for Fill Finish Manufacturing of Lyophilised Biopharmaceuticals by the development of an in situ analytical method compliant with the orange guide requirements for ID.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10431_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Many products have a frozen intermediate step for DS prior to Fill Finish Manufacturing, often DS is shipped in multiple containers from the DS site to the DP site and as per the orange guide for parenteral biopharmaceuticals, each container is required to be identified. This usually requires liquid state sampling and testing by HPLC or Dot Blot for example. Opportunities to ID the frozen bulk provides a significant improvement to the manufacturing process.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_10431_8 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Dr Sarah Hudson, University of Limerick.</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-10431",{position:"center_center",ids:"divi-area-sanofi-non-invasive-characterisation-of-lyophilised-biopharmaceuticals"},"addTrigger",DiviArea)</script>  <div id="divi-area-11489" class="divi-area-wrap divi-area-wrap-11489 divi-area-wrap-regeneron-a-cfd-approach-to-aerated-fed-batch-cell-culture-bioreactors divi-area-type-popup divi-area-regeneron-a-cfd-approach-to-aerated-fed-batch-cell-culture-bioreactors" style="display:none;"><div class="et_pb_section et_pb_section_dap_11489_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11489_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11489_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11489_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Regeneron.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Regeneron.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Regeneron-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Regeneron-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11492" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11489_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11489_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>A CFD Approach to Aerated Fed-Batch Cell Culture Bioreactors</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11489_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">The goal of this project is to develop a PhD student over a four-year period in the area of computational fluid dynamic modelling. The student will work closely with the Regeneron Process Sciences team and will divide her time between UL and Regeneron thus benefitting from the experience of working as part of an industry-based team. The objective of this study is to investigate Chinese Hamster Ovary (CHO) cell growth and how productivity is affected by aeration, stirring or mixing. The project aims to computationally model the kinetics of cell cultures at varying process scales and will study the effect of different spargers and various flow rates on oxygen mass transfer, CO2 production and cell growth in production bioreactors at various scale.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11489_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Harry Van Den Akker and PhD Roya Jamshidian, University of Limerick.</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11489",{position:"center_center",ids:"divi-area-regeneron-a-cfd-approach-to-aerated-fed-batch-cell-culture-bioreactors"},"addTrigger",DiviArea)</script>  <div id="divi-area-11527" class="divi-area-wrap divi-area-wrap-11527 divi-area-wrap-abbvie-continuous-anti-solvent-crystallisation-in-a-crystalliser-without-moving-parts divi-area-type-popup divi-area-abbvie-continuous-anti-solvent-crystallisation-in-a-crystalliser-without-moving-parts" style="display:none;"><div class="et_pb_section et_pb_section_dap_11527_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11527_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11527_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11527_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Abbvie.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Abbvie.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Abbvie-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Abbvie-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11534" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11527_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11527_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Continuous Anti-solvent Crystallisation in a Crystalliser without Moving Parts</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11527_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">The goal of this project is to develop a systematic methodology for design, optimisation and scale-up of continuous crystallisers without any moving parts. Fluidic oscillator designs will be developed for enhancing their performance as continuous anti-solvent crystallizers for industrially relevant systems. A base line fluidic oscillator will be configured based on prior studies. Appropriate methodology will be developed for in-line analysis of crystalliser performance. Systematic design of experiments will be developed and executed to generate new insights and useful data. Various attributes of produced crystals will be thoroughly characterised. Computational fluid dynamics models with population balance models will be developed to simulate complex solid – liquid flow during crystallisation in fluidic oscillator. Initially the models will be used for simulating shear, mixing, and residence time distribution. The models and the experimental data will be used to obtain key parameters of crystallisation kinetics. The computational models will be used to explore large parameter space. Influence of uncertainty associated with mixing, nucleation and growth kinetics (activation energy, rate coefficients), supersaturation etc. will be evaluated. Machine learning approaches will be developed and optimised. The obtained optimal neural network structures combined with the CFD+PBM models (hybrid models) will be used to obtain quantitative relationship between key design and operating parameters and crystalliser performance. Hybrid models will allow adequate capturing of complex non linear processes influencing performance. These will be used to guide development of optimal configuration as well as number scale-up options without compromising performance. The models and results will be used to develop key insights and specific recommendations for use of fluidic oscillator as continuous crystallisers. The project aims to computationally model the kinetics of cell cultures at varying process scales and will study the effect of different spargers and various flow rates on oxygen mass transfer, CO2 production and cell growth in production bioreactors at various scale.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11527_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Vivek Ranade and PhD Vaishnavi Honavar, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11527",{position:"center_center",ids:"divi-area-abbvie-continuous-anti-solvent-crystallisation-in-a-crystalliser-without-moving-parts"},"addTrigger",DiviArea)</script>  <div id="divi-area-11528" class="divi-area-wrap divi-area-wrap-11528 divi-area-wrap-syngenta-thermodynamic-solubility-of-biologically-active-molecules divi-area-type-popup divi-area-syngenta-thermodynamic-solubility-of-biologically-active-molecules" style="display:none;"><div class="et_pb_section et_pb_section_dap_11528_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11528_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11528_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11528_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sygenta.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sygenta.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sygenta-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Sygenta-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11538" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11528_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11528_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1> Thermodynamic Solubility of Biologically Active Molecules</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11528_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">The goal of the project is to develop a novel materials science approach to control the thermodynamic solubility of biologically active molecules such as active pharmaceutical ingredients (APIs) and agrichemical ingredients (AIs). A library of novel pharmaceutical materials which incorporate model compounds, APIs and AIs will be synthesised and structurally characterised. The aqueous solubility of the synthesised materials will then be determined by HPLC and thermal analysis will be used to characterise melting points and other phase transitions to investigate how the physiochemical properties of the API or model compounds are affected. In later stages of the project, the mechanisms of API/model compound dissolution will be investigated. The project also aims to develop modelling and measurement approaches to rapidly translate to broad solid-state discovery. The project aims to computationally model the kinetics of cell cultures at varying process scales and will study the effect of different spargers and various flow rates on oxygen mass transfer, CO2 production and cell growth in production bioreactors at various scale.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11528_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Michael Zaworotko, postdoctoral researchers Dr Rana Sanii and PhDs Daniel O’Hearn and Molly Haskins</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11528",{position:"center_center",ids:"divi-area-syngenta-thermodynamic-solubility-of-biologically-active-molecules"},"addTrigger",DiviArea)</script>  <div id="divi-area-11529" class="divi-area-wrap divi-area-wrap-11529 divi-area-wrap-msd-design-of-highly-specific-gene-knockout-agents divi-area-type-popup divi-area-msd-design-of-highly-specific-gene-knockout-agents" style="display:none;"><div class="et_pb_section et_pb_section_dap_11529_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11529_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11529_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11529_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD.jpg 480w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2021/04/CaseStudy_MSD-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-10271" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11529_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11529_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Design of Highly specific Gene Knockout Agents</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11529_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">This project aims to design highly specific gene knockout agents by using rational design and structure activity relationship (SAR) methodologies. The DNA damaging agents will initially be composed of copper-based artificial metallo-nucleases (AMNs) tethered to triplex forming oligonucleotides (TFOs) via click chemistry. These will be studied in-vitro for DNA binding, triplex stabilization, and oxidative damaging properties. To achieve this we have segregated the body of work into two parts. Part A aims to further develop stand-alone AMNs previously discovered in our group. Insights into the SAR of AMNs developed in part A will then be used to develop “Ready to Click” AMNs in part B that will then be used for gene-targeting through TFO conjugation.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11529_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Assoc. Prof. Andrew Kellett. Postdoctoral researchers: Dr Georgia Menounou and PhD Alex Gibney, Dublin City University</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11529",{position:"center_center",ids:"divi-area-msd-design-of-highly-specific-gene-knockout-agents"},"addTrigger",DiviArea)</script>  <div id="divi-area-11530" class="divi-area-wrap divi-area-wrap-11530 divi-area-wrap-lilly-pfizer-janssen-msd-bms-multi-product-resin-reuse-for-biopharmaceutical-manufacturing divi-area-type-popup divi-area-lilly-pfizer-janssen-msd-bms-multi-product-resin-reuse-for-biopharmaceutical-manufacturing" style="display:none;"><div class="et_pb_section et_pb_section_dap_11530_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11530_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11530_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11530_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_MultiLogos1.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_MultiLogos1.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_MultiLogos1-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_MultiLogos1-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11536" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11530_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11530_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Multi-Product Resin Reuse for Biopharmaceutical Manufacturing</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11530_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">This project investigates the multi-product use of a resin in downstream biopharmaceutical production. Currently resins are used repeatedly for batches of the same product with a predetermined column cleaning regime. The proposed project aims to investigate the feasibility of extending resin reuse to a second product. The proposed project will build on the White Paper ‘Multiproduct Resin Reuse for Clinical and Commercial Manufacturing—Methodology and Acceptance Criteria’ published in the PDA Journal of Science and Technology in 2018. This study concentrated on resin and column performance, product carryover and cleaning effectiveness following use with multiple products.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11530_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Sarah Hudson, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11530",{position:"center_center",ids:"divi-area-lilly-pfizer-janssen-msd-bms-multi-product-resin-reuse-for-biopharmaceutical-manufacturing"},"addTrigger",DiviArea)</script>  <div id="divi-area-11531" class="divi-area-wrap divi-area-wrap-11531 divi-area-wrap-hexafly-isolation-and-purification-of-hexameal-amp-and-characterisation-of-its-effect-on-mrsa divi-area-type-popup divi-area-hexafly-isolation-and-purification-of-hexameal-amp-and-characterisation-of-its-effect-on-mrsa" style="display:none;"><div class="et_pb_section et_pb_section_dap_11531_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11531_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11531_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11531_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Hexafly.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Hexafly.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Hexafly-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Hexafly-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11535" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11531_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11531_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Isolation and purification of Hexameal AMP and characterisation of its effect on MRSA</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11531_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">This project builds on work completed in a previous project with Hexafly titled “Isolation, identification and characterisation of an antimicrobial peptide from Hexameal”. Hexafly is an Irish Biotech company that have developed the use of insects as a novel food source. Previously a highly active antimicrobial peptide (AMP) was isolated from insect meal (Hexameal). This project characterised the mode of action of the AMP against a variety of drug resistant bacteria. When MRSA was exposed to the AMP there was a disruption of cell wall synthesis and cell death indicating the potential for the AMP to be used to treat drug resistant bacterial infections.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11531_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Kevin Kavanagh and postdoctoral researchers Dr Anatte Margalit, Maynooth University</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11531",{position:"center_center",ids:"divi-area-hexafly-isolation-and-purification-of-hexameal-amp-and-characterisation-of-its-effect-on-mrsa"},"addTrigger",DiviArea)</script>  <div id="divi-area-11532" class="divi-area-wrap divi-area-wrap-11532 divi-area-wrap-serosep-development-for-freeze-drying-cycle-for-large-volume-entericbio divi-area-type-popup divi-area-serosep-development-for-freeze-drying-cycle-for-large-volume-entericbio" style="display:none;"><div class="et_pb_section et_pb_section_dap_11532_0 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_dap_11532_1"><div class="et_pb_column et_pb_column_1_4 et_pb_column_dap_11532_2 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_dap_11532_3 et_pb_image_sticky_tablet"> <span class="et_pb_image_wrap has-box-shadow-overlay"><div class="box-shadow-overlay"></div><img src="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Serosep.jpg" alt="" title="Scale-Up_Systems_CaseStudy" srcset="https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Serosep.jpg 480w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Serosep-300x300.jpg 300w, https://sspc.ie/wp-content/uploads/2022/09/CaseStudy_Serosep-150x150.jpg 150w" sizes="(max-width: 480px) 100vw, 480px" class="wp-image-11537" /></span></div></div><div class="et_pb_column et_pb_column_3_4 et_pb_column_dap_11532_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_dap_11532_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h1>Development for freeze drying cycle for large volume EntericBio</h1></div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11532_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner">The overall aim of this project is to determine ways in which to optimize this process for higher volumes. This will be achieved by first defining the CQAs of the initial standard samples and then revisiting the FD process using DoE as an effective statistical tool for mapping the effect of process factors (temperature, heating and cooling rate at each of the loading, freezing, primary drying, secondary drying and unloading) on the CQAs.</div></div><div class="et_pb_module et_pb_text et_pb_text_dap_11532_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p><strong>Led by Prof. Gavin Walker, University of Limerick</strong></p></div></div></div></div></div></div> <script>(function(a,b,c,d){d.addAction("ready",function(){d.register(a,b,function(e){e[c]('on-hash','hash',{})})},2)})("divi-area-11532",{position:"center_center",ids:"divi-area-serosep-development-for-freeze-drying-cycle-for-large-volume-entericbio"},"addTrigger",DiviArea)</script>  <script type="application/javascript"> (function() { var file = ["https:\/\/sspc.ie\/wp-content\/et-cache\/12331\/et-divi-dynamic-tb-138-12331-late.css"]; var handle = document.getElementById('divi-style-inline-inline-css'); var location = handle.parentNode; if (0===document.querySelectorAll('link[href="' + file + '"]').length) { var link = document.createElement('link'); link.rel = 'stylesheet'; link.id = 'et-dynamic-late-css'; link.href = file; location.insertBefore(link, handle.nextSibling); } })(); </script> <script type="text/javascript"> var et_animation_data = [{"class":"et_pb_row_3","style":"flipBottom","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_row_7","style":"zoom","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_column_24","style":"foldTop","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_column_25","style":"foldTop","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_column_26","style":"foldTop","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_column_27","style":"foldTop","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_column_28","style":"foldTop","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_blurb_0_tb_footer","style":"bounce","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_image_1_tb_footer","style":"slideLeft","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"},{"class":"et_pb_image_2_tb_footer","style":"slideRight","repeat":"once","duration":"1000ms","delay":"0ms","intensity":"50%","starting_opacity":"0%","speed_curve":"ease-in-out"}]; var et_link_options_data = [{"class":"et_pb_column_1","url":"https:\/\/sspc.ie\/sspc-research-discover-our-impacts#research-impact-area-sustainability","target":"_self"},{"class":"et_pb_column_2","url":"https:\/\/sspc.ie\/sspc-research-discover-our-impacts#research-impact-area-small-molecule","target":"_self"},{"class":"et_pb_column_3","url":"https:\/\/sspc.ie\/sspc-research-discover-our-impacts#research-impact-area-biologics","target":"_self"},{"class":"et_pb_column_4","url":"https:\/\/sspc.ie\/sspc-research-discover-our-impacts#research-impact-area-health","target":"_self"},{"class":"et_pb_column_5","url":"https:\/\/sspc.ie\/sspc-research-discover-our-impacts#research-impact-area-education-public-engagement","target":"_self"},{"class":"et_pb_blurb_6","url":"https:\/\/sspc.ie\/sspc-awards-series-2022\/","target":"_self"},{"class":"et_pb_blurb_7","url":"https:\/\/sspc.ie\/industry\/","target":"_self"},{"class":"et_pb_blurb_0_tb_footer","url":"https:\/\/sspcireland.sharepoint.com\/sites\/SSPC_Main","target":"_blank"}]; </script><div class="wt-cli-cookie-bar-container" data-nosnippet="true"><div id="cookie-law-info-bar" role="dialog" aria-live="polite" aria-label="cookieconsent" aria-describedby="wt-cli-cookie-banner" data-cli-geo-loc="0" style="" class="wt-cli-cookie-bar"><div class="cli-wrapper"><span id="wt-cli-cookie-banner"><div class="cli-bar-container cli-style-v2"><div class="cli-bar-message">Cookies are small text files that we save on your device when you use our website. 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