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class="breadcrumb-current-title">Back to Basics – Protein Characterization in Research and Pharmaceutical Development</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-17812 post type-post status-publish format-standard has-post-thumbnail category-biopharmaceutical category-pharmaceutical category-proteomics tag-biopharmaceutical tag-lc-m-sms tag-protein-characterization entry" aria-label="Back to Basics – Protein Characterization in Research and Pharmaceutical Development"><header class="entry-header"><h1 class="entry-title">Back to Basics – Protein Characterization in Research and Pharmaceutical Development</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/analyteguru/tf-author/lizzie-gallagher/" title="Posts by Lizzie Gallagher" rel="author">Lizzie Gallagher, Market Development Manager, Pharma and BioPharma, Thermo Fisher Scientific</a> </span> <span class="post-info-date"> 05.16.2024 </span> </header><div class="entry-content"> <h3 class="wp-block-heading" id="h-protein-characterization-and-its-importance"><strong>Protein characterization and its importance</strong></h3> <p>Protein characterization is a critical aspect of modern biological research and pharmaceutical development. It involves the analysis of protein structures, their interactions, and the modifications they undergo, which are essential for understanding their function and mechanisms of action in biological systems. The <a href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/biopharma-finder-software.html?cid=E.24CMD.PB102.22240.01" target="_blank" rel="noreferrer noopener">Thermo Scientific BioPharma Finder software</a> is a powerful integrated software solution that automates the intact protein analysis of LC-MS data and peptide mapping analysis of LC-MS/MS data, providing in-depth characterization of proteins.</p> <h3 class="wp-block-heading" id="h-the-role-of-protein-characterization-in-drug-discovery"><strong>The role of protein characterization in drug discovery</strong></h3> <div class="wp-block-image"> <figure class="alignright size-large is-resized"><img decoding="async" width="1024" height="1024" src="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2-1024x1024.jpg" alt="" class="wp-image-17814" style="width:443px;height:auto" srcset="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2-1024x1024.jpg 1024w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2-300x300.jpg 300w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2-150x150.jpg 150w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2-768x768.jpg 768w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2-80x80.jpg 80w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/05/ba-002799-pb-protein-therapeutics-banners-social-1080x1080-2.jpg 1080w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure></div> <p>Protein characterization plays a pivotal role in drug discovery. It aids in the production and characterization of protein targets at various stages of drug development. This includes protein purification, binding quantification, and biotherapeutic analysis. The <a href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/biopharma-finder-software.html?cid=E.24CMD.PB102.22240.01" target="_blank" rel="noreferrer noopener">Thermo Scientific BioPharma Finder software</a>, for instance, can rapidly assess sequence integrity, glycan profile, and antigen binding activity in a single measurement using only picomoles of material.</p> <h3 class="wp-block-heading" id="h-modern-challenges-in-protein-characterization"><strong>Modern challenges in protein characterization</strong></h3> <p>Despite the advancements in protein characterization, several challenges persist. These include the complexity of proteoforms, the varied dynamic range of protein expression, and the loss of information due to “missed values” in MS experiments. Traditional techniques for studying protein structures, such as X-ray crystallography, cryo-electron microscopy, and nuclear magnetic resonance, have limitations, including the requirement of large amounts of highly purified proteins and the inability to analyze proteins in their native conditions.</p> <h3 class="wp-block-heading" id="h-overcoming-challenges-using-thermo-fisher-scientific-workflows"><strong>Overcoming challenges using Thermo Fisher Scientific workflows</strong></h3> <p>Thermo Fisher Scientific offers solutions to these challenges through its advanced workflows. The BioPharma Finder application, for instance, enables the identification and relative quantitation of disulfide bonds, post-translational modifications (PTMs), and sequence variants. It also provides top-down analysis for fast screening of site-specific modifications using complex workflows in an industrial setting.</p> <p>Moreover, the <a href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms.html?cid=E.24CMD.PB102.22240.01" target="_blank" rel="noreferrer noopener">Thermo Scientific Orbitrap technology</a>, when used with the BioPharma Finder application, allows for the most accurate and confident PTM profiles and identifications. For targeted protein quantitation, modern turnkey MS workflows have been developed to minimize biases during the MS analysis. You can learn more about our complete solutions for <a href="https://assets.thermofisher.com/TFS-Assets/CMD/brochures/br-002727-pb-biopharma-brand-campaign-br002727-na-en.pdf" target="_blank" rel="noreferrer noopener">biopharmaceutical analysis here.</a></p> <h3 class="wp-block-heading" id="h-the-future-of-protein-characterization-with-thermo-fisher-scientific"><strong>The future of protein characterization with Thermo Fisher Scientific</strong></h3> <p>Looking ahead, Thermo Fisher Scientific continues to innovate and develop new technologies to further enhance protein characterization. You can stay up to date with biopharmaceutical technology advancements by signing up to receive our dedicated <a href="https://www.thermofisher.com/us/en/home/global/forms/industrial/biopharmaceutical-resources-promotions-information-request.html?cid=E.24CMD.PB102.22240.01" target="_blank" rel="noreferrer noopener">Pharma & Biopharma News and Updates</a>. These advancements aim to provide researchers with more accurate, efficient, and comprehensive tools for protein analysis, accelerating the pace of biotherapeutic development and bringing life-changing biotherapeutics to the market faster than ever before.</p> <p>On LinkedIn? Visit our <a href="https://www.linkedin.com/showcase/chromatography-&-mass-spectrometry/posts/?feedView=all" target="_blank" rel="noreferrer noopener">LinkedIn page</a> #BioPharmaceutical #orbitrap #MassSpectrometry #ProteinCharacterization</p> </div></article><section class="author-box"><h4 class="author-box-title">Lizzie Gallagher</h4><div class="author-box-content" itemprop="description">Lizzie Gallagher is a market development manager for the pharma and biopharma market at Thermo Fisher Science, having spent a number of years in both industry, and sales and marketing. Lizzie has widespread experience with the challenges and trends of the biopharma and pharma market. </div></section><div class="adjacent-entry-pagination pagination"><div class="pagination-previous alignleft"><i class="fa fa-icon fa-chevron-left"></i> <a href="https://www.thermofisher.com/blog/analyteguru/using-isotope-analysis-to-understand-phosphorus-cycling-changes/" rel="prev">Using Isotope Analysis to Understand Phosphorus Cycling Changes</a></div><div class="pagination-next alignright"><a href="https://www.thermofisher.com/blog/analyteguru/exploring-lithium-ion-battery-anode-degradation-with-ic-ms-ms/" rel="next">Exploring Lithium-Ion Battery Anode Degradation Using IC-MS/MS</a> <i class="fa fa-icon fa-chevron-right"></i></div></div></main></div></div><footer class="site-footer"><div class="wrap"><div class="creds"><p class="footer-links"><a href="https://corporate.thermofisher.com/en/footer/privacy-statement.html" target="_blank" rel="noopener noreferrer">Privacy Statement</a><a href="https://corporate.thermofisher.com/en/footer/terms-and-conditions.html" target="_blank" rel="noopener noreferrer">Terms & Conditions</a><a href="/blog/locations/">Locations</a><a href="/blog/sitemap/">Sitemap</a></p><p>© 2024 <a href="https://www.thermofisher.com">Thermo Fisher Scientific</a>. 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