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class="vector-toc-list"> </ul> </li> <li id="toc-Farmaci" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmaci"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Farmaci</span> </div> </a> <ul id="toc-Farmaci-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bibliografia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Bibliografia"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Bibliografia</span> </div> </a> <ul id="toc-Bibliografia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voci_correlate" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voci_correlate"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Voci correlate</span> </div> </a> <ul id="toc-Voci_correlate-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Altri_progetti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Altri_progetti"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Altri progetti</span> </div> </a> <ul id="toc-Altri_progetti-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Collegamenti_esterni" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Collegamenti_esterni"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Collegamenti esterni</span> </div> </a> <ul id="toc-Collegamenti_esterni-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Indice" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l'indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Mostra/Nascondi l'indice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Alcol deidrogenasi</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 30 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-30" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">30 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%86%D8%A7%D8%B2%D8%B9%D8%A9_%D9%87%D9%8A%D8%AF%D8%B1%D9%88%D8%AC%D9%8A%D9%86_%D8%A7%D9%84%D9%83%D8%AD%D9%88%D9%84" title="نازعة هيدروجين الكحول - arabo" lang="ar" hreflang="ar" data-title="نازعة هيدروجين الكحول" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%90%D0%BB%D0%BA%D0%BE%D1%85%D0%BE%D0%BB%D0%B4%D0%B5%D1%85%D0%B8%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%B0%D0%B7%D0%B0" title="Алкохолдехидрогеназа - bulgaro" lang="bg" hreflang="bg" data-title="Алкохолдехидрогеназа" data-language-autonym="Български" data-language-local-name="bulgaro" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Alkoholna_dehidrogenaza" title="Alkoholna dehidrogenaza - bosniaco" lang="bs" hreflang="bs" data-title="Alkoholna dehidrogenaza" data-language-autonym="Bosanski" data-language-local-name="bosniaco" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Alcohol_deshidrogenasa" title="Alcohol deshidrogenasa - catalano" lang="ca" hreflang="ca" data-title="Alcohol deshidrogenasa" data-language-autonym="Català" data-language-local-name="catalano" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Alkoholdehydrogen%C3%A1za" title="Alkoholdehydrogenáza - ceco" lang="cs" hreflang="cs" data-title="Alkoholdehydrogenáza" data-language-autonym="Čeština" data-language-local-name="ceco" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Alkoholdehydrogenase" title="Alkoholdehydrogenase - danese" lang="da" hreflang="da" data-title="Alkoholdehydrogenase" data-language-autonym="Dansk" data-language-local-name="danese" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Alkoholdehydrogenase" title="Alkoholdehydrogenase - tedesco" lang="de" hreflang="de" data-title="Alkoholdehydrogenase" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Alcohol_dehydrogenase" title="Alcohol dehydrogenase - inglese" lang="en" hreflang="en" data-title="Alcohol dehydrogenase" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Alcohol-deshidrogenasa" title="Alcohol-deshidrogenasa - spagnolo" lang="es" hreflang="es" data-title="Alcohol-deshidrogenasa" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%D9%84%DA%A9%D9%84_%D8%AF%D9%87%DB%8C%D8%AF%D8%B1%D9%88%DA%98%D9%86%D8%A7%D8%B2" title="الکل دهیدروژناز - persiano" lang="fa" hreflang="fa" data-title="الکل دهیدروژناز" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Alkoholidehydrogenaasi" title="Alkoholidehydrogenaasi - finlandese" lang="fi" hreflang="fi" data-title="Alkoholidehydrogenaasi" data-language-autonym="Suomi" data-language-local-name="finlandese" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Alcool_d%C3%A9shydrog%C3%A9nase" title="Alcool déshydrogénase - francese" lang="fr" hreflang="fr" data-title="Alcool déshydrogénase" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Alcohol_deshidroxenase" title="Alcohol deshidroxenase - galiziano" lang="gl" hreflang="gl" data-title="Alcohol deshidroxenase" data-language-autonym="Galego" data-language-local-name="galiziano" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Alkohol-dehidrogen%C3%A1z" title="Alkohol-dehidrogenáz - ungherese" lang="hu" hreflang="hu" data-title="Alkohol-dehidrogenáz" data-language-autonym="Magyar" data-language-local-name="ungherese" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Alkohol_dehidrogenase" title="Alkohol dehidrogenase - indonesiano" lang="id" hreflang="id" data-title="Alkohol dehidrogenase" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesiano" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB%E3%83%87%E3%83%92%E3%83%89%E3%83%AD%E3%82%B2%E3%83%8A%E3%83%BC%E3%82%BC" title="アルコールデヒドロゲナーゼ - giapponese" lang="ja" hreflang="ja" data-title="アルコールデヒドロゲナーゼ" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%95%8C%EC%BD%94%EC%98%AC_%ED%83%88%EC%88%98%EC%86%8C%ED%9A%A8%EC%86%8C" title="알코올 탈수소효소 - coreano" lang="ko" hreflang="ko" data-title="알코올 탈수소효소" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%90%D0%BB%D0%BA%D0%BE%D1%85%D0%BE%D0%BB_%D0%B4%D0%B5%D1%85%D0%B8%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%B0%D0%B7%D0%B0" title="Алкохол дехидрогеназа - macedone" lang="mk" hreflang="mk" data-title="Алкохол дехидрогеназа" data-language-autonym="Македонски" data-language-local-name="macedone" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Alcoholdehydrogenase" title="Alcoholdehydrogenase - olandese" lang="nl" hreflang="nl" data-title="Alcoholdehydrogenase" data-language-autonym="Nederlands" data-language-local-name="olandese" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Dehydrogenaza_alkoholowa" title="Dehydrogenaza alkoholowa - polacco" lang="pl" hreflang="pl" data-title="Dehydrogenaza alkoholowa" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/%C3%81lcool_desidrogenase" title="Álcool desidrogenase - portoghese" lang="pt" hreflang="pt" data-title="Álcool desidrogenase" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Alcool_dehidrogenaz%C4%83" title="Alcool dehidrogenază - rumeno" lang="ro" hreflang="ro" data-title="Alcool dehidrogenază" data-language-autonym="Română" data-language-local-name="rumeno" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D0%BB%D0%BA%D0%BE%D0%B3%D0%BE%D0%BB%D1%8C%D0%B4%D0%B5%D0%B3%D0%B8%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%B0%D0%B7%D0%B0" title="Алкогольдегидрогеназа - russo" lang="ru" hreflang="ru" data-title="Алкогольдегидрогеназа" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Alkohol_dehidrogenaza_(NADP%2B)" title="Alkohol dehidrogenaza (NADP+) - serbo-croato" lang="sh" hreflang="sh" data-title="Alkohol dehidrogenaza (NADP+)" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Alkoholdehydrogen%C3%A1za" title="Alkoholdehydrogenáza - slovacco" lang="sk" hreflang="sk" data-title="Alkoholdehydrogenáza" data-language-autonym="Slovenčina" data-language-local-name="slovacco" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Alkohol-dehidrogenaza" title="Alkohol-dehidrogenaza - sloveno" lang="sl" hreflang="sl" data-title="Alkohol-dehidrogenaza" data-language-autonym="Slovenščina" data-language-local-name="sloveno" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Alkohol_dehidrogenaza_(NADP%2B)" title="Alkohol dehidrogenaza (NADP+) - serbo" lang="sr" hreflang="sr" data-title="Alkohol dehidrogenaza (NADP+)" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Alkoholdehydrogenas" title="Alkoholdehydrogenas - svedese" lang="sv" hreflang="sv" data-title="Alkoholdehydrogenas" data-language-autonym="Svenska" data-language-local-name="svedese" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%BB%D0%BA%D0%BE%D0%B3%D0%BE%D0%BB%D1%8C%D0%B4%D0%B5%D0%B3%D1%96%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%B0%D0%B7%D0%B0" title="Алкогольдегідрогеназа - ucraino" lang="uk" hreflang="uk" data-title="Алкогольдегідрогеназа" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%86%87%E8%84%AB%E6%B0%AB%E9%85%B6" title="醇脫氫酶 - cinese" lang="zh" hreflang="zh" data-title="醇脫氫酶" data-language-autonym="中文" data-language-local-name="cinese" 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summary="Tabella sinottica che riassume i principali dati del soggetto"><tbody><tr class="sinottico_testata"><th colspan="2" style="background: #C2C3FF; color:#000;">alcol deidrogenasi</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><span typeof="mw:File"><a href="/wiki/File:1a4u.jpg" class="mw-file-description" title="Modello tridimensionale dell'enzima"><img alt="Modello tridimensionale dell'enzima" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/1a4u.jpg/220px-1a4u.jpg" decoding="async" width="220" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/e/e0/1a4u.jpg 1.5x" data-file-width="240" data-file-height="240" /></a></span><br /><small>Alcol deidrogenasi umana</small></td></tr><tr><th><a href="/wiki/Classificazione_EC" title="Classificazione EC">Numero EC</a></th><td>1.1.1.1 </td></tr><tr><th>Classe</th><td><a href="/wiki/Ossidoreduttasi" title="Ossidoreduttasi">Ossidoreduttasi</a> </td></tr><tr class="sinottico_divisione"><th colspan="2">Nome sistematico</th></tr><tr><td class="sinottico_testo_centrale" colspan="2">alcol:NAD+ ossidoreduttasi </td></tr><tr class="sinottico_divisione"><th colspan="2">Altri nomi</th></tr><tr><td class="sinottico_testo_centrale" colspan="2">aldeide reduttasi; ADH </td></tr><tr><th>Banche dati</th><td><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1">BRENDA</a>, <a rel="nofollow" class="external text" href="http://enzyme.expasy.org/EC/1.1.1.1">EXPASY</a>, <a rel="nofollow" class="external text" href="http://xpdb.nist.gov/enzyme_thermodynamics/enzyme_compose_query.pl?EC=1.1.1.1">GTD</a>, PDB (<a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:1.1.1.1">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:1.1.1.1">PDBe</a> <a rel="nofollow" class="external text" href="https://pdbj.org/mine/sql?query=SELECT+DISTINCT+pdbid+FROM+entity+WHERE+entity.pdbx_ec%3D%271.1.1.1%27">PDBj</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=1.1.1.1">PDBsum</a>) </td></tr><tr><td colspan="2" class="sinottico_piede" style="background:#FFC253; color:#000;">Fonte: <a rel="nofollow" class="external text" href="http://www.enzyme-database.org/query.php?ec=1.1.1.1">IUBMB</a> </td></tr><tr><td class="sinottico_piede2 noprint nomobile metadata" colspan="2"><a href="https://www.wikidata.org/wiki/Q410754" class="extiw" title="d:Q410754"><span title="Modifica i dati della voce Alcol deidrogenasi su Wikidata">Modifica dati su Wikidata</span></a><b> ·</b> <a href="/wiki/Template:Enzima/man" title="Template:Enzima/man"><span title="Manuale del template Enzima">Manuale</span></a></td></tr></tbody></table> <p>La <b>alcol deidrogenasi</b> (<b>ADH</b>) è un <a href="/wiki/Enzima" title="Enzima">enzima</a> appartenente alla classe delle <a href="/wiki/Ossidoreduttasi" title="Ossidoreduttasi">ossidoreduttasi</a>, che catalizza la seguente <a href="/wiki/Reazione_chimica" title="Reazione chimica">reazione</a>. Si tratta di una reazione reversibile che avviene nel citosol. </p> <dl><dd>alcol + NAD<sup>+</sup> <style data-mw-deduplicate="TemplateStyles:r107150125">.mw-parser-output .Unicode{font-family:TITUS Cyberbit Basic,Code2000,Doulos SIL,Chrysanthi Unicode,Bitstream Cyberbit,Bitstream CyberBase,Bitstream Vera,Thryomanes,Gentium,GentiumAlt,Visual Geez Unicode,Lucida Grande,Arial Unicode MS,Microsoft Sans Serif,Lucida Sans Unicode;font-family:inherit}</style><span class="Unicode" style="font-family:Antinoou, Code2000, Code2001, TITUS Cyberbit Basic, Doulos SIL, Chrysanthi Unicode, Arial Unicode MS, Bitstream Cyberbit, Bitstream Vera, Gentium, GentiumAlt, Lucida Sans Unicode, Noto Sans Mandaic, Penuturesu, Segoe UI Symbol; font-family :inherit;">⇄</span> aldeide o chetone + NADH + H<sup>+</sup></dd></dl> <p>Si tratta di una proteina con un <a href="/wiki/Dito_di_zinco" title="Dito di zinco">dito di zinco</a> (per funzionare, ADH richiede la presenza di zinco), che agisce su <a href="/wiki/Alcoli" title="Alcoli">alcoli</a> primari e secondari. Negli <a href="/wiki/Animali" class="mw-redirect" title="Animali">animali</a>, ma non nei <a href="/wiki/Lieviti" class="mw-redirect" title="Lieviti">lieviti</a>, agisce anche su alcoli secondari ciclici. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Ruolo_metabolico">Ruolo metabolico</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=1" title="Modifica la sezione Ruolo metabolico" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=1" title="Edit section's source code: Ruolo metabolico"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nell'uomo e in molti altri animali il ruolo <a href="/wiki/Metabolismo" title="Metabolismo">metabolico</a> è quello di <a href="/wiki/Catabolismo" title="Catabolismo">catabolizzare</a> alcoli che altrimenti sarebbero tossici. Nel <a href="/wiki/Lievito" title="Lievito">lievito</a> e in molti <a href="/wiki/Batteri" class="mw-redirect" title="Batteri">batteri</a> essi catalizzano la reazione opposta (formazione di alcoli a partire da aldeidi) come parte della <a href="/wiki/Fermentazione" title="Fermentazione">fermentazione</a> alcolica. </p><p>Questo enzima è quindi il responsabile della catalisi dell'<a href="/wiki/Etanolo" title="Etanolo">etanolo</a> e del <a href="/wiki/Metanolo" title="Metanolo">metanolo</a>. L'etanolo viene convertito in <a href="/wiki/Acetaldeide" title="Acetaldeide">acetaldeide</a>, mentre il metanolo in <a href="/wiki/Formaldeide" title="Formaldeide">formaldeide</a>, composto notoriamente tossico in grado di ledere la vista e in grandi quantità condurre alla morte: ciò significa che il pericolo conseguente all'ingestione di metanolo non deriva dal composto in sé, ma dall'azione catalitica dell'alcol deidrogenasi. Un buon modo per risolvere casi clinici di questo tipo è quello di somministrare quantità maggiori di etanolo che viene convertito in <a href="/wiki/Acetaldeide" title="Acetaldeide">acetaldeide</a>: l'alcol deidrogenasi infatti presenta un'affinità maggiore per l'etanolo, che funge da inibitore competitivo nei confronti del metanolo, e dunque in uguali concentrazioni l'alcol deidrogenasi si lega al primo ignorando il secondo che viene eliminato tramite i reni. Nei bambini al di sotto dei 5 anni la tossicità di alcol è più elevata a causa della fisiologica carenza di alcol-deidrogenasi epatica. Nel bambino 5ml/kg di alcol assoluto possono essere letali; per un bambino di 15 kg è già pericolosa la dose di 25 ml. </p> <div class="mw-heading mw-heading2"><h2 id="Altre_alcol_deidrogenasi">Altre alcol deidrogenasi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=2" title="Modifica la sezione Altre alcol deidrogenasi" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=2" title="Edit section's source code: Altre alcol deidrogenasi"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Esistono diversi altri tipi di alcol deidrogenasi, tutte appartenenti alla sotto-sottoclasse <a href="/wiki/EC_1.1.1" title="EC 1.1.1">EC 1.1.1</a>, come: </p> <ul><li><a href="/wiki/Alcol_deidrogenasi_(NADP%2B)" title="Alcol deidrogenasi (NADP+)">alcol deidrogenasi (NADP+)</a>, che utilizza <a href="/wiki/NADP" class="mw-redirect" title="NADP">NADP</a><sup>+</sup> come coenzima;</li> <li><a href="/wiki/Allil-alcol_deidrogenasi" title="Allil-alcol deidrogenasi">allil-alcol deidrogenasi</a>;</li> <li><a href="/wiki/Alcol_deidrogenasi_(NAD(P)%2B)" title="Alcol deidrogenasi (NAD(P)+)">alcol deidrogenasi (NAD(P)+)</a>;</li> <li><a href="/wiki/Aril-alcol_deidrogenasi" title="Aril-alcol deidrogenasi">aril-alcol deidrogenasi</a>;</li> <li><a href="/wiki/Aril-alcol_deidrogenasi_(NADP%2B)" title="Aril-alcol deidrogenasi (NADP+)">aril-alcol deidrogenasi (NADP+)</a>;</li> <li><a href="/wiki/3-idrossibenzil-alcol_deidrogenasi" title="3-idrossibenzil-alcol deidrogenasi">3-idrossibenzil-alcol deidrogenasi</a>;</li> <li><a href="/wiki/Perillil-alcol_deidrogenasi" title="Perillil-alcol deidrogenasi">perillil-alcol deidrogenasi</a>;</li> <li><a href="/wiki/(alcol_a_lunga_catena)_deidrogenasi" title="(alcol a lunga catena) deidrogenasi">(alcol a lunga catena) deidrogenasi</a>;</li> <li><a href="/wiki/Coniferil-alcol_deidrogenasi" title="Coniferil-alcol deidrogenasi">coniferil-alcol deidrogenasi</a>;</li> <li><a href="/wiki/Cinnamil-alcol_deidrogenasi" title="Cinnamil-alcol deidrogenasi">cinnamil-alcol deidrogenasi</a>;</li> <li><a href="/wiki/Alcol_deidrogenasi_(accettore)" title="Alcol deidrogenasi (accettore)">alcol deidrogenasi (accettore)</a> (appartenente alla sotto-sottoclasse <a href="/wiki/EC_1.1.99" title="EC 1.1.99">EC 1.1.99</a>).</li></ul> <p>L'alcol deidrogenasi classe I metabolizza la maggior parte dell'alcol, in quanto presenta il maggior grado di affinità. Nonostante alcol deidrogenasi classe II e classe II abbiano bassa affinità con il substrato, svolgono un ruolo fondamentale nel metabolismo dell'etanolo quando quest'ultimo è presente in alta concentrazione; in questo caso, questi enzimi lo metabolizzano velocemente aiutando nella reazione. </p> <div class="mw-heading mw-heading2"><h2 id="Farmaci">Farmaci</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=3" title="Modifica la sezione Farmaci" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=3" title="Edit section's source code: Farmaci"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'alcol deidrogenasi viene inibita dal farmaco <a href="/wiki/Fomepizolo" title="Fomepizolo">fomepizolo</a>, utilizzato per trattare il glicole etilenico o overdose da metanolo. </p> <div class="mw-heading mw-heading2"><h2 id="Bibliografia">Bibliografia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=4" title="Modifica la sezione Bibliografia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=4" title="Edit section's source code: Bibliografia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Brändén, G.-I., Jörnvall, H., Eklund, H. e Furugren, B. <i>Alcohol dehydrogenase</i>. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 11, Academic Press, New York, 1975, pp. 103–190.</li> <li>Jörnvall, H. <i>Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects</i>. Eur. J. Biochem. 72 (1977) 443–452. <a href="/wiki/Entrez" title="Entrez">Entrez PubMed</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=320001">320001</a></li> <li>Negelein, E. e Wulff, H.-J. <i>Diphosphopyridinproteid ackohol, acetaldehyd</i>. Biochem. Z. 293 (1937) 351–389.</li> <li>Sund, H. e Theorell, H. <i>Alcohol dehydrogenase</i>. In: Boyer, P.D., Lardy, H. e Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 7, Academic Press, New York, 1963, pp. 25–83.</li> <li>Theorell, H. <i>Kinetics and equilibria in the liver alcohol dehydrogenase system</i>. Adv. Enzymol. Relat. Subj. Biochem. 20 (1958) 31–49. <a href="/wiki/Entrez" title="Entrez">Entrez PubMed</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13605979">13605979</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Voci_correlate">Voci correlate</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=5" title="Modifica la sezione Voci correlate" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=5" title="Edit section's source code: Voci correlate"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Sistema_microsomiale_di_ossidazione_dell%27etanolo" title="Sistema microsomiale di ossidazione dell'etanolo">Sistema microsomiale di ossidazione dell'etanolo</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=6" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=6" title="Edit section's source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><span class="plainlinks" title="commons:Category:Alcohol dehydrogenase"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Alcohol_dehydrogenase?uselang=it">Wikimedia Commons</a></span></li></ul></div> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/?uselang=it" title="Collabora a Wikimedia Commons"><img alt="Collabora a Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png" decoding="async" width="18" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/27px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/36px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/?uselang=it">Wikimedia Commons</a></span> contiene immagini o altri file su <b><span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Alcohol_dehydrogenase?uselang=it">alcol deidrogenasi</a></span></b></li></ul> <div class="mw-heading mw-heading2"><h2 id="Collegamenti_esterni">Collegamenti esterni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Alcol_deidrogenasi&veaction=edit&section=7" title="Modifica la sezione Collegamenti esterni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Alcol_deidrogenasi&action=edit&section=7" title="Edit section's source code: Collegamenti esterni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li class="mw-empty-elt"></li> <li><cite id="CITEREFBritannica.com" class="citation web" style="font-style:normal">(<span style="font-weight:bolder; font-size:80%"><abbr title="inglese">EN</abbr></span>) <a rel="nofollow" class="external text" href="https://www.britannica.com/science/alcohol-dehydrogenase"><span style="font-style:italic;">alcohol dehydrogenase</span></a>, su <span style="font-style:italic;"><a href="/wiki/Enciclopedia_Britannica" title="Enciclopedia Britannica">Enciclopedia Britannica</a></span>, Encyclopædia Britannica, Inc.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q410754#P1417" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li></ul> <div class="noprint" style="width:100%; 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