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fl-row-full-width fl-row-bg-photo fl-node-oycusdnf1v54 fl-row-custom-height fl-row-align-center" data-node="oycusdnf1v54"> <div class="fl-row-content-wrap"> <div class="uabb-row-separator uabb-top-row-separator" > </div> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-zsi102vtr93x" data-node="zsi102vtr93x"> <div class="fl-col fl-node-pc1w2ifmvahs" data-node="pc1w2ifmvahs"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-suxy7p8249qa" data-node="suxy7p8249qa"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img fetchpriority="high" decoding="async" class="fl-photo-img wp-image-2517 size-full" src="https://alspstudy.com/wp-content/uploads/2022/03/illuminate_logo_large-tagline-white-01.png" alt="illuminate_logo_large tagline white-01" itemprop="image" height="301" width="970" title="illuminate_logo_large tagline white-01" srcset="https://alspstudy.com/wp-content/uploads/2022/03/illuminate_logo_large-tagline-white-01.png 970w, https://alspstudy.com/wp-content/uploads/2022/03/illuminate_logo_large-tagline-white-01-300x93.png 300w, https://alspstudy.com/wp-content/uploads/2022/03/illuminate_logo_large-tagline-white-01-768x238.png 768w" sizes="(max-width: 970px) 100vw, 970px" /> </div> </div> </div> </div> </div> </div> <div class="fl-col fl-node-2uijmyenz3xa fl-col-small" data-node="2uijmyenz3xa"> <div class="fl-col-content fl-node-content"></div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-photo fl-node-bj9f2ykw85gm fl-row-custom-height fl-row-align-center" data-node="bj9f2ykw85gm"> <div class="fl-row-content-wrap"> <div class="uabb-row-separator uabb-top-row-separator" > </div> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-j5autxq4kc3p" data-node="j5autxq4kc3p"> <div class="fl-col fl-node-qby74rsalnmv" data-node="qby74rsalnmv"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-rich-text fl-node-kny6h4i5w2z9" data-node="kny6h4i5w2z9"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><span style="font-weight: 400;">The main purpose of the study is to learn more about how ALSP occurs and how the disease affects </span><span style="font-weight: 400;">people</span><span style="font-weight: 400;"> over time.聽 Study participants will not receive any investigational drugs as part of this study and will continue their standard of care treatment during the study.</span></p> <p><span style="font-weight: 400;">Vigil Neuroscience is developing an investigational drug, iluzanebart (VGL101), for the treatment of people with ALSP. Our goal is that this natural history study will provide information that may help with the development of future treatments for ALSP, including iluzanebart.聽</span></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="whocanparticipate" class="fl-row fl-row-full-width fl-row-bg-color fl-node-kf42n98uby60 fl-row-default-height fl-row-align-center" data-node="kf42n98uby60"> <div class="fl-row-content-wrap"> <div class="uabb-row-separator uabb-top-row-separator" > </div> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-t7f012rz5ny9" data-node="t7f012rz5ny9"> <div class="fl-col fl-node-l3r8sncotdu5 fl-col-small" data-node="l3r8sncotdu5"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-42oz6rsqun9t" data-node="42oz6rsqun9t"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2592 size-full" src="https://alspstudy.com/wp-content/uploads/2022/12/Illuminate_people.png" alt="Illuminate_people" itemprop="image" height="351" width="381" title="Illuminate_people" srcset="https://alspstudy.com/wp-content/uploads/2022/12/Illuminate_people.png 381w, https://alspstudy.com/wp-content/uploads/2022/12/Illuminate_people-300x276.png 300w" sizes="(max-width: 381px) 100vw, 381px" /> </div> </div> </div> </div> </div> </div> <div class="fl-col fl-node-byrfgeu7txv4 fl-col-small" data-node="byrfgeu7txv4"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-7jtcgvoxkepq" data-node="7jtcgvoxkepq"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">Who can participate?</span> </h2> </div> </div> <div class="fl-module fl-module-rich-text fl-node-0j2sm5gi4nvw" data-node="0j2sm5gi4nvw"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>To participate in this study, individuals will need to meet the following main criteria*</p> <ul> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">18 years of age or older</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">Documentation of a gene variant in the </span><i><span style="font-weight: 400;">CSF1R</span></i><span style="font-weight: 400;"> gene</span></li> <li style="font-weight: 400;" aria-level="1">Diagnosed with ALSP and have MRI findings consistent with ALSP</li> <li aria-level="1">Having clinical symptoms of ALSP</li> </ul> <p> </p> <p><span style="font-size: 12px; line-height: 5px;"><em>*There are additional inclusion and exclusion criteria for this study.</em></span></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-nh7r0fwubacv fl-row-default-height fl-row-align-center" data-node="nh7r0fwubacv"> <div class="fl-row-content-wrap"> <div class="uabb-row-separator uabb-top-row-separator" > </div> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-vs89euh3461g" data-node="vs89euh3461g"> <div class="fl-col fl-node-aui1gvwy8t56 fl-col-has-cols" data-node="aui1gvwy8t56"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-1bagnmx3s6k5" data-node="1bagnmx3s6k5"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">About the Illuminate Study</span> </h2> </div> </div> <div class="fl-col-group fl-node-1te4rwx8bykz fl-col-group-nested" data-node="1te4rwx8bykz"> <div class="fl-col fl-node-1mc8xq0f9trb fl-col-small" data-node="1mc8xq0f9trb"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-gakyx8q51uc4" data-node="gakyx8q51uc4"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2588 size-thumbnail" src="https://alspstudy.com/wp-content/uploads/2022/12/illuminate-icon-3-150x150.png" alt="illuminate icon 3" itemprop="image" height="150" width="150" title="illuminate icon 3" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-ye0s2xd86g5m" data-node="ye0s2xd86g5m"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>Study participation will last approximately 37 months and will include approximately 7 study visits to the study site.</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-sknc2y9tigbw fl-col-small" data-node="sknc2y9tigbw"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-02doh8qpbsx1" data-node="02doh8qpbsx1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2590 size-thumbnail" src="https://alspstudy.com/wp-content/uploads/2022/12/ill-vial-150x150.png" alt="ill vial" itemprop="image" height="150" width="150" title="ill vial" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-8ji4nhm97bwr" data-node="8ji4nhm97bwr"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>During the study, blood samples will be collected along with MRI images, and performance and cognitive assessments and questionnaires.</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-ngz1ovcd53p2 fl-col-small" data-node="ngz1ovcd53p2"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-4czhv2ef3awq" data-node="4czhv2ef3awq"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2591 size-thumbnail" src="https://alspstudy.com/wp-content/uploads/2022/12/ill-car-150x150.png" alt="ill car" itemprop="image" height="150" width="150" title="ill car" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-w7me5c4digra" data-node="w7me5c4digra"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>Travel assistance and stipends for participation are available to participants and caregivers.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-color fl-node-lonh0e2pc7xr fl-row-default-height fl-row-align-center" data-node="lonh0e2pc7xr"> <div class="fl-row-content-wrap"> <div class="uabb-row-separator uabb-top-row-separator" > </div> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-br7wnxv2u4lk" data-node="br7wnxv2u4lk"> <div class="fl-col fl-node-eqx6s2vyluaf" data-node="eqx6s2vyluaf"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-rejga3h5tvox" data-node="rejga3h5tvox"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">Where will the study take place?</span> </h2> </div> </div> <div class="fl-module fl-module-rich-text fl-node-c30wqyjlufn4" data-node="c30wqyjlufn4"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><span style="font-weight: 400;">The study will have sites in the following countries. Travel assistance and stipends for participation are available to participants and caregivers.</span></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-hd7jni9oq048 fl-col-group-equal-height fl-col-group-align-center" data-node="hd7jni9oq048"> <div class="fl-col fl-node-vnbr5iwup1t7 fl-col-small" data-node="vnbr5iwup1t7"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-giposrtxl5k2" data-node="giposrtxl5k2"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2555 size-full" src="https://alspstudy.com/wp-content/uploads/2022/11/Flags_usa.png" alt="Flags_usa" itemprop="image" height="86" width="130" title="Flags_usa" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-pjyef4uhx75g" data-node="pjyef4uhx75g"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>United States</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-a57ngeti2491 fl-col-small" data-node="a57ngeti2491"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-wiz7u1s2890f" data-node="wiz7u1s2890f"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-webp"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2675 size-medium" src="https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Brazil.svg-300x210.webp" alt="Flag_of_Brazil.svg" itemprop="image" height="210" width="300" title="Flag_of_Brazil.svg" srcset="https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Brazil.svg-300x210.webp 300w, https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Brazil.svg.webp 640w" sizes="(max-width: 300px) 100vw, 300px" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-83dszvhg04uf" data-node="83dszvhg04uf"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>Brazil</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-3e56juign7o0 fl-col-small" data-node="3e56juign7o0"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-vreidlsmxho1" data-node="vreidlsmxho1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-webp"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2676 size-large" src="https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Canada_Pantone.svg-1024x512.webp" alt="Flag_of_Canada_(Pantone).svg" itemprop="image" height="512" width="1024" title="Flag_of_Canada_(Pantone).svg" srcset="https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Canada_Pantone.svg-1024x512.webp 1024w, https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Canada_Pantone.svg-300x150.webp 300w, https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Canada_Pantone.svg-768x384.webp 768w, https://alspstudy.com/wp-content/uploads/2024/09/Flag_of_Canada_Pantone.svg.webp 1200w" sizes="(max-width: 1024px) 100vw, 1024px" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-2uqzormkasf1" data-node="2uqzormkasf1"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>Canada</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-q1jirabo8yn4 fl-col-small" data-node="q1jirabo8yn4"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-41zs6ce8oxrd" data-node="41zs6ce8oxrd"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2556 size-full" src="https://alspstudy.com/wp-content/uploads/2022/11/Flags_germany.png" alt="Flags_germany" itemprop="image" height="86" width="130" title="Flags_germany" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-tpj98cmbrde6" data-node="tpj98cmbrde6"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>Germany</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-dqc1tznam58p fl-col-small" data-node="dqc1tznam58p"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-0gpwzk2h97fr" data-node="0gpwzk2h97fr"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2557 size-full" src="https://alspstudy.com/wp-content/uploads/2022/11/Flags_netherlands.png" alt="Flags_netherlands" itemprop="image" height="86" width="130" title="Flags_netherlands" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-m0sqz4e3y98k" data-node="m0sqz4e3y98k"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>Netherlands</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-05z4toi72j8m fl-col-small" data-node="05z4toi72j8m"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-31a6kncvuxge" data-node="31a6kncvuxge"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-2558 size-full" src="https://alspstudy.com/wp-content/uploads/2022/11/Flags_uk.png" alt="Flags_uk" itemprop="image" height="86" width="130" title="Flags_uk" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-ec9lxpn6s475" data-node="ec9lxpn6s475"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>United Kingdom</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-j0qahnw8xumo fl-row-default-height fl-row-align-center" data-node="j0qahnw8xumo"> <div class="fl-row-content-wrap"> <div class="uabb-row-separator uabb-top-row-separator" > </div> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-xzqkj9tb02an" data-node="xzqkj9tb02an"> <div class="fl-col fl-node-a8pt026mzndy" data-node="a8pt026mzndy"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-ybrh4s5eq80c" data-node="ybrh4s5eq80c"> 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