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href="https://www.academia.edu/116868498/Risk_for_Thyroid_Cancer_Recurrence_Is_Higher_in_Men_Than_in_Women_Independent_of_Disease_Stage_at_Presentation"><img alt="Research paper thumbnail of Risk for Thyroid Cancer Recurrence Is Higher in Men Than in Women Independent of Disease Stage at Presentation" class="work-thumbnail" src="https://attachments.academia-assets.com/112878865/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116868498/Risk_for_Thyroid_Cancer_Recurrence_Is_Higher_in_Men_Than_in_Women_Independent_of_Disease_Stage_at_Presentation">Risk for Thyroid Cancer Recurrence Is Higher in Men Than in Women Independent of Disease Stage at Presentation</a></div><div class="wp-workCard_item"><span>Thyroid</span><span>, Jun 1, 2020</span></div><div class="wp-workCard_item 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116868493/Extraocular_Muscle_Enlargement_in_Acromegaly"><img alt="Research paper thumbnail of Extraocular Muscle Enlargement in Acromegaly" class="work-thumbnail" src="https://attachments.academia-assets.com/112878862/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116868493/Extraocular_Muscle_Enlargement_in_Acromegaly">Extraocular Muscle Enlargement in Acromegaly</a></div><div class="wp-workCard_item"><span>Journal of Neuro-ophthalmology</span><span>, May 11, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e6112ebf3da05fc0fac2b51183ebd64c" 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655898/Factor_V_Leiden_mutation_prothrombin_gene_mutation_and_deficiencies_in_coagulation_inhibitors_associated_with_Budd_Chiari_syndrome_and_portal_vein_thrombosis_results_of_a_case_control_study"><img alt="Research paper thumbnail of Factor V Leiden mutation, prothrombin gene mutation and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis : results of a case-control study" class="work-thumbnail" src="https://attachments.academia-assets.com/110560246/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655898/Factor_V_Leiden_mutation_prothrombin_gene_mutation_and_deficiencies_in_coagulation_inhibitors_associated_with_Budd_Chiari_syndrome_and_portal_vein_thrombosis_results_of_a_case_control_study">Factor V Leiden mutation, prothrombin gene mutation and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis : results of a case-control study</a></div><div class="wp-workCard_item"><span>Blood</span><span>, Oct 1, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c18eb0828d770ebf0341bbe218fb9fc6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560246,"asset_id":113655898,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560246/download_file?st=MTczMjUyMTcwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We compared 43 BCS patients and 92 PVT patients with 474 population-based controls. The relative risk of BCS was 11.3 (95% CI 4.8-26.5) for individuals with factor V Leiden mutation, 2.1(95% CI 0.4-9.6) for those with prothrombin gene mutation, and 6.8 (95% CI 1.9-24.4) for those with protein C deficiency. The relative risk of PVT was 2.7 (95% CI 1.1-6.9) for individuals with factor V Leiden mutation, 1.4 (95% CI 0.4-5.2) for those with prothrombin gene mutation, and 4.6 (95% CI 1.5-14.1) for those with protein C deficiency. The relative risk of BCS or PVT was not increased in the presence of inherited protein S or antithrombin deficiency. Concurrence of either acquired or inherited thrombotic risk factors was observed in 26% of the BCS patients and 37% of the PVT patients. We conclude that factor V Leiden mutation and hereditary protein C deficiency appear to be important risk factors for BCS and PVT. Although the prevalence of the prothrombin gene mutation was increased, it was not found to be a significant risk factor for BCS and PVT. The coexistence of thrombogenic risk factors in many patients indicates that BCS and PVT can be the result of a combined effect of different pathogenetic 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655894/Management_of_Hypoparathyroidism">Management of Hypoparathyroidism</a></div><div class="wp-workCard_item"><span>Journal of Bone and Mineral Research</span><span>, Oct 31, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the prese...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the presence of a low or inappropriately normal parathyroid hormone level. HypoPT is most commonly seen after neck surgery, which accounts for approximately 75% of cases, whereas approximately 25% have HypoPT due to nonsurgical causes. In both groups of patients, conventional therapy includes calcium and active vitamin D analogue therapy aiming to maintain serum calcium concentration in the low normal or just below the normal reference range and normalize serum phosphorus, magnesium concentrations, and urine calcium levels. The limitations of conventional therapy include wide fluctuations in serum calcium, high pill burden, poor quality of life, and renal complications. Parathyroid hormone (PTH) replacement therapy may improve the biochemical profile in those in whom conventional therapy proves unsatisfactory. Based on a systematic review and meta‐analysis of the literature, the panel made a graded recommendation suggesting conventional therapy as first line therapy rather than administration of PTH (weak recommendation, low quality evidence). 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Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655894"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655894"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655894; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655894]").text(description); $(".js-view-count[data-work-id=113655894]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655894; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655894']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655894, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113655894]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655894,"title":"Management of Hypoparathyroidism","translated_title":"","metadata":{"abstract":"ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the presence of a low or inappropriately normal parathyroid hormone level. 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The limitations of conventional therapy include wide fluctuations in serum calcium, high pill burden, poor quality of life, and renal complications. Parathyroid hormone (PTH) replacement therapy may improve the biochemical profile in those in whom conventional therapy proves unsatisfactory. Based on a systematic review and meta‐analysis of the literature, the panel made a graded recommendation suggesting conventional therapy as first line therapy rather than administration of PTH (weak recommendation, low quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers use of PTH. Because pregnancy and lactation are associated with changes in calcium homeostasis, close monitoring is required during these periods with appropriate adjustment of calcium and active vitamin D analogue therapy to ensure that serum calcium remains in the mid to low normal reference range in order to avoid maternal and fetal complications. Emerging therapies include molecules with prolonged PTH action as well as different mechanisms of action that may significantly enhance drug efficacy and safety. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","internal_url":"https://www.academia.edu/113655894/Management_of_Hypoparathyroidism","translated_internal_url":"","created_at":"2024-01-17T13:11:58.249-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Management_of_Hypoparathyroidism","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":203383,"name":"Parathyroid Hormone","url":"https://www.academia.edu/Documents/in/Parathyroid_Hormone"},{"id":438516,"name":"Bone Mineral Density","url":"https://www.academia.edu/Documents/in/Bone_Mineral_Density"},{"id":2343787,"name":"Hypoparathyroidism","url":"https://www.academia.edu/Documents/in/Hypoparathyroidism"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":38675445,"url":"https://doi.org/10.1002/jbmr.4716"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655893"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655893/Retinotopic_organization_of_the_primary_visual_cortex_before_and_after_pharmacological_treatment_for_a_large_prolactinoma_with_compression_of_the_optic_chiasm"><img alt="Research paper thumbnail of Retinotopic organization of the primary visual cortex before and after pharmacological treatment for a large prolactinoma with compression of the optic chiasm" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655893/Retinotopic_organization_of_the_primary_visual_cortex_before_and_after_pharmacological_treatment_for_a_large_prolactinoma_with_compression_of_the_optic_chiasm">Retinotopic organization of the primary visual cortex before and after pharmacological treatment for a large prolactinoma with compression of the optic chiasm</a></div><div class="wp-workCard_item"><span>Journal of Vision</span><span>, Sep 1, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have visual deficits, typically bilateral hemianopsia, because of chiasmal compression. Treatment of macroadenomas is usually successful, and thus such patients provide a unique opportunity for studying neuroplasticity in the human visual system and its consequences for vision. This case study focuses on patient BS, a 48-year-old man, who had a large prolactinoma, a common pituitary tumor, and, as a consequence, a severe visual field loss. We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of primary visual cortex (V1) of patient BS before and after successful treatment of his prolactinoma with cabergoline over the course of 13 months. In addition, we used the same fMRI protocol to examine the organization of V1 in a healthy age- and gender-matched control participant with normal vision. Humphrey&#39;s perimetry was used to assess the integrity of the visual fields, before and after the completion of treatment for patient BS, and over two successive scans in the healthy control. The Humphrey field exam revealed significant visual improvement after treatment and this recovery was accompanied by substantial changes in V1 activation. Before the start of treatment, the amount of cortical tissue in V1 which was activated by the retinotopic stimuli was only 21% that of the healthy control participant. After treatment, the amount of activation normalized to approximately 90% of that of the control participant. The organization of retinotopic representations in V1 also normalized after treatment. These results illustrate that the visual system is capable of repair following conservative medical treatment, opening the door for assessing the effects of compression on different components of the optic nerve and tract. Meeting abstract presented at VSS 2015.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655893"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655893"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655893; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655893]").text(description); $(".js-view-count[data-work-id=113655893]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655893; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655893']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655893, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113655893]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655893,"title":"Retinotopic organization of the primary visual cortex before and after pharmacological treatment for a large prolactinoma with compression of the optic chiasm","translated_title":"","metadata":{"abstract":"Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have visual deficits, typically bilateral hemianopsia, because of chiasmal compression. Treatment of macroadenomas is usually successful, and thus such patients provide a unique opportunity for studying neuroplasticity in the human visual system and its consequences for vision. This case study focuses on patient BS, a 48-year-old man, who had a large prolactinoma, a common pituitary tumor, and, as a consequence, a severe visual field loss. We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of primary visual cortex (V1) of patient BS before and after successful treatment of his prolactinoma with cabergoline over the course of 13 months. In addition, we used the same fMRI protocol to examine the organization of V1 in a healthy age- and gender-matched control participant with normal vision. Humphrey\u0026#39;s perimetry was used to assess the integrity of the visual fields, before and after the completion of treatment for patient BS, and over two successive scans in the healthy control. The Humphrey field exam revealed significant visual improvement after treatment and this recovery was accompanied by substantial changes in V1 activation. Before the start of treatment, the amount of cortical tissue in V1 which was activated by the retinotopic stimuli was only 21% that of the healthy control participant. After treatment, the amount of activation normalized to approximately 90% of that of the control participant. The organization of retinotopic representations in V1 also normalized after treatment. These results illustrate that the visual system is capable of repair following conservative medical treatment, opening the door for assessing the effects of compression on different components of the optic nerve and tract. Meeting abstract presented at VSS 2015.","publisher":"Association for Research in Vision and Ophthalmology","publication_date":{"day":1,"month":9,"year":2015,"errors":{}},"publication_name":"Journal of Vision"},"translated_abstract":"Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have visual deficits, typically bilateral hemianopsia, because of chiasmal compression. Treatment of macroadenomas is usually successful, and thus such patients provide a unique opportunity for studying neuroplasticity in the human visual system and its consequences for vision. This case study focuses on patient BS, a 48-year-old man, who had a large prolactinoma, a common pituitary tumor, and, as a consequence, a severe visual field loss. We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of primary visual cortex (V1) of patient BS before and after successful treatment of his prolactinoma with cabergoline over the course of 13 months. In addition, we used the same fMRI protocol to examine the organization of V1 in a healthy age- and gender-matched control participant with normal vision. Humphrey\u0026#39;s perimetry was used to assess the integrity of the visual fields, before and after the completion of treatment for patient BS, and over two successive scans in the healthy control. The Humphrey field exam revealed significant visual improvement after treatment and this recovery was accompanied by substantial changes in V1 activation. Before the start of treatment, the amount of cortical tissue in V1 which was activated by the retinotopic stimuli was only 21% that of the healthy control participant. After treatment, the amount of activation normalized to approximately 90% of that of the control participant. The organization of retinotopic representations in V1 also normalized after treatment. These results illustrate that the visual system is capable of repair following conservative medical treatment, opening the door for assessing the effects of compression on different components of the optic nerve and tract. Meeting abstract presented at VSS 2015.","internal_url":"https://www.academia.edu/113655893/Retinotopic_organization_of_the_primary_visual_cortex_before_and_after_pharmacological_treatment_for_a_large_prolactinoma_with_compression_of_the_optic_chiasm","translated_internal_url":"","created_at":"2024-01-17T13:11:57.993-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Retinotopic_organization_of_the_primary_visual_cortex_before_and_after_pharmacological_treatment_for_a_large_prolactinoma_with_compression_of_the_optic_chiasm","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49962,"name":"Visual Cortex","url":"https://www.academia.edu/Documents/in/Visual_Cortex"},{"id":59692,"name":"Vision","url":"https://www.academia.edu/Documents/in/Vision"},{"id":777648,"name":"Hemianopsia","url":"https://www.academia.edu/Documents/in/Hemianopsia"},{"id":914074,"name":"Visual Field","url":"https://www.academia.edu/Documents/in/Visual_Field"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3827606,"name":"prolactinoma","url":"https://www.academia.edu/Documents/in/prolactinoma"}],"urls":[{"id":38675444,"url":"https://doi.org/10.1167/15.12.587"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655892"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655892/Central_hypothyroidism"><img alt="Research paper thumbnail of Central hypothyroidism" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655892/Central_hypothyroidism">Central hypothyroidism</a></div><div class="wp-workCard_item"><span>PubMed</span><span>, Jun 1, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655892"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655892"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655892; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655891"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655891/_Generalized_histoplasmosis_due_to_endogenous_reactivation_of_a_latent_infection_in_an_HIV_seronegative_man_"><img alt="Research paper thumbnail of [Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man]" class="work-thumbnail" src="https://attachments.academia-assets.com/110560288/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655891/_Generalized_histoplasmosis_due_to_endogenous_reactivation_of_a_latent_infection_in_an_HIV_seronegative_man_">[Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man]</a></div><div class="wp-workCard_item"><span>PubMed</span><span>, Jul 15, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duratio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. This case report illustrates that disseminated histoplasmosis may mimic Crohn's disease leading to a delay in the diagnosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a55634cf05f36524fad1635ef7e5927" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560288,"asset_id":113655891,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560288/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655891"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655891"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655891; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655891]").text(description); $(".js-view-count[data-work-id=113655891]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655891; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655891']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655891, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1a55634cf05f36524fad1635ef7e5927" } } $('.js-work-strip[data-work-id=113655891]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655891,"title":"[Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man]","translated_title":"","metadata":{"abstract":"A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. This case report illustrates that disseminated histoplasmosis may mimic Crohn's disease leading to a delay in the diagnosis.","publication_date":{"day":15,"month":7,"year":1995,"errors":{}},"publication_name":"PubMed"},"translated_abstract":"A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655890"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655890/Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey"><img alt="Research paper thumbnail of Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655890/Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey">Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey</a></div><div class="wp-workCard_item"><span>Journal of Bone and Mineral Research</span><span>, Nov 14, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired quality of life (QoL). The goals of management for chronic HypoPT include improvement in QoL and the prevention of both hypo‐ and hypercalcemia symptoms and long‐term complications. Several groups have provided consensus statements and guidelines on the management of HypoPT; however, due to limited evidence, these recommendations have largely been based on literature reviews, expert opinion, and consensus statements. The objective of this study was to use a systematic approach to describe current practice for the initial assessment and follow‐up of patients with chronic HypoPT. We developed a survey asking experts in the field to select the responses that best reflect their current practice. The survey found no differences in responses between nonsurgical and postsurgical patient assessment. For new patients, respondents usually performed an assessment of serum lab profile (calcium [either albumin‐adjusted or ionized], magnesium, creatinine, phosphate, 25‐hydroxyvitamin D), 24‐hour urine (creatinine, calcium), and a renal ultrasound to evaluate for the presence of nephrocalcinosis or nephrolithiasis. For follow‐up patients, most respondents perform blood tests and urine tests every 6 months or less frequently. The reported clinical practice patterns for monitoring for complications of chronic HypoPT vary considerably among respondents. Based on the responses in this systematic expert practice survey, we provide practice suggestions for initial assessment and follow‐up of patients with chronic HypoPT. In addition, we highlight areas with significant variation in practice and identify important areas for future research. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655890"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655890"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655890; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655890]").text(description); $(".js-view-count[data-work-id=113655890]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655890; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655890']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655890, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113655890]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655890,"title":"Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey","translated_title":"","metadata":{"abstract":"ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired quality of life (QoL). The goals of management for chronic HypoPT include improvement in QoL and the prevention of both hypo‐ and hypercalcemia symptoms and long‐term complications. Several groups have provided consensus statements and guidelines on the management of HypoPT; however, due to limited evidence, these recommendations have largely been based on literature reviews, expert opinion, and consensus statements. The objective of this study was to use a systematic approach to describe current practice for the initial assessment and follow‐up of patients with chronic HypoPT. We developed a survey asking experts in the field to select the responses that best reflect their current practice. The survey found no differences in responses between nonsurgical and postsurgical patient assessment. For new patients, respondents usually performed an assessment of serum lab profile (calcium [either albumin‐adjusted or ionized], magnesium, creatinine, phosphate, 25‐hydroxyvitamin D), 24‐hour urine (creatinine, calcium), and a renal ultrasound to evaluate for the presence of nephrocalcinosis or nephrolithiasis. For follow‐up patients, most respondents perform blood tests and urine tests every 6 months or less frequently. The reported clinical practice patterns for monitoring for complications of chronic HypoPT vary considerably among respondents. Based on the responses in this systematic expert practice survey, we provide practice suggestions for initial assessment and follow‐up of patients with chronic HypoPT. In addition, we highlight areas with significant variation in practice and identify important areas for future research. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","publisher":"Wiley-Blackwell","publication_date":{"day":14,"month":11,"year":2022,"errors":{}},"publication_name":"Journal of Bone and Mineral Research"},"translated_abstract":"ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired quality of life (QoL). The goals of management for chronic HypoPT include improvement in QoL and the prevention of both hypo‐ and hypercalcemia symptoms and long‐term complications. Several groups have provided consensus statements and guidelines on the management of HypoPT; however, due to limited evidence, these recommendations have largely been based on literature reviews, expert opinion, and consensus statements. The objective of this study was to use a systematic approach to describe current practice for the initial assessment and follow‐up of patients with chronic HypoPT. We developed a survey asking experts in the field to select the responses that best reflect their current practice. The survey found no differences in responses between nonsurgical and postsurgical patient assessment. For new patients, respondents usually performed an assessment of serum lab profile (calcium [either albumin‐adjusted or ionized], magnesium, creatinine, phosphate, 25‐hydroxyvitamin D), 24‐hour urine (creatinine, calcium), and a renal ultrasound to evaluate for the presence of nephrocalcinosis or nephrolithiasis. For follow‐up patients, most respondents perform blood tests and urine tests every 6 months or less frequently. The reported clinical practice patterns for monitoring for complications of chronic HypoPT vary considerably among respondents. Based on the responses in this systematic expert practice survey, we provide practice suggestions for initial assessment and follow‐up of patients with chronic HypoPT. In addition, we highlight areas with significant variation in practice and identify important areas for future research. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","internal_url":"https://www.academia.edu/113655890/Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey","translated_internal_url":"","created_at":"2024-01-17T13:11:57.425-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":52836,"name":"Clinical Practice","url":"https://www.academia.edu/Documents/in/Clinical_Practice"},{"id":221411,"name":"Systematic review","url":"https://www.academia.edu/Documents/in/Systematic_review"},{"id":438516,"name":"Bone Mineral Density","url":"https://www.academia.edu/Documents/in/Bone_Mineral_Density"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":38675441,"url":"https://doi.org/10.1002/jbmr.4698"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655889"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655889/Consensus_Recommendations_for_the_Diagnosis_and_Management_of_Well_Differentiated_Gastroenterohepatic_Neuroendocrine_Tumours_A_Revised_Statement_from_a_Canadian_National_Expert_Group"><img alt="Research paper thumbnail of Consensus Recommendations for the Diagnosis and Management of Well-Differentiated Gastroenterohepatic Neuroendocrine Tumours: A Revised Statement from a Canadian National Expert Group" class="work-thumbnail" src="https://attachments.academia-assets.com/110560243/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655889/Consensus_Recommendations_for_the_Diagnosis_and_Management_of_Well_Differentiated_Gastroenterohepatic_Neuroendocrine_Tumours_A_Revised_Statement_from_a_Canadian_National_Expert_Group">Consensus Recommendations for the Diagnosis and Management of Well-Differentiated Gastroenterohepatic Neuroendocrine Tumours: A Revised Statement from a Canadian National Expert Group</a></div><div class="wp-workCard_item"><span>Current Oncology</span><span>, Jun 1, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9aacdd13aeeb600ae2dddca354e4abef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560243,"asset_id":113655889,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560243/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655889"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655889"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655889; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655888"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655888/Stress_Pathways_to_Spontaneous_Preterm_Birth_The_Role_of_Stressors_Psychological_Distress_and_Stress_Hormones"><img alt="Research paper thumbnail of Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones" class="work-thumbnail" src="https://attachments.academia-assets.com/110560241/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655888/Stress_Pathways_to_Spontaneous_Preterm_Birth_The_Role_of_Stressors_Psychological_Distress_and_Stress_Hormones">Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones</a></div><div class="wp-workCard_item"><span>American Journal of Epidemiology</span><span>, Apr 10, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0ccc056f0e8fc5b79b8b28420dad28d5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560241,"asset_id":113655888,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560241/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655888"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655888"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655888; 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In addition, a nested case-control analysis (207 cases, 444 controls) was used to explore potential biologic pathways by analyzing maternal plasma corticotrophin-releasing hormone (CRH), placental histopathology, and (in a subset) maternal hair cortisol. Among the large number of stress and distress measures studied, only pregnancy-related anxiety was consistently and independently associated with spontaneous preterm birth (for values above the median, adjusted odds ratio ¼ 1.8 (95% confidence interval: 1.3, 2.4)), with a dose-response relation across quartiles. The maternal plasma CRH concentration was significantly higher in cases than in controls in crude analyses but not after adjustment (for concentrations above the median, adjusted odds ratio ¼ 1.1 (95% confidence interval: 0.8, 1.6)). In the subgroup (n ¼ 117) of participants with a sufficient maternal hair sample, hair cortisol was positively associated with gestational age. 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}); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655887"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655887/Opioid_induced_endocrinopathies"><img alt="Research paper thumbnail of Opioid-induced endocrinopathies" class="work-thumbnail" src="https://attachments.academia-assets.com/110560239/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655887/Opioid_induced_endocrinopathies">Opioid-induced endocrinopathies</a></div><div class="wp-workCard_item"><span>The Lancet Diabetes & Endocrinology</span><span>, 2020</span></div><div class="wp-workCard_item 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endocrinopathies","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"ΤAs the use of opioids is becoming a global epidemic and has led to a rise in expanding, so has the occurrence and recognition of their impact consequences on the endocrine system. Nonetheless, opioid-induced endocrinopathies still remain under-diagnosed, mainly due to symptom under-reporting by patients and lack of awareness in clinicians. Hypogonadism is the most well recognised consequence but These include hypogonadism, inhibitory effects on the hypothalamo-pituitary-adrenal axis and negative impact on bone health also require attention.. Hyperprolactinaemia may also be detected, whereas, clinically relevant thyroid dysfunction has not been identified. EThe effects on other hormones have not been as yet clearly defined. At present, consensus or evidence-based guidelines on how to diagnose and manage these endocrinopathies are lacking. ANonetheless, assessment of gonadal and adrenal function (particularly if in the presence of high index of clinical suspicion), and, as well as evaluation of bone health are advised in these patients. Discontinuation or reduction of the opioid dose and appropriate hormone replacement are management approaches for hypogonadism and hypoadrenalism. Further research is needed to fully elucidate the impact of opioids at all levels of the endocrine system and the optimal management of their consequences.Further research facilitating the development of evidence-based guidelines on the diagnosis and optimal management of opioid-induced endocrinopathies is eagerly awaited.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"The Lancet Diabetes \u0026 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System","url":"https://www.academia.edu/Documents/in/Endocrine_System"},{"id":3331893,"name":"discontinuation","url":"https://www.academia.edu/Documents/in/discontinuation"}],"urls":[{"id":38675437,"url":"http://pure-oai.bham.ac.uk/ws/files/68274341/Opioid_induced_endocrinopathies_revised_final.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655886"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655886/Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease"><img alt="Research paper thumbnail of Recombinant Human Thyroid Stimulating Hormone versus Thyroid Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/110560285/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655886/Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease">Recombinant Human Thyroid Stimulating Hormone versus Thyroid Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease</a></div><div class="wp-workCard_item"><span>Journal of Oncology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease","translated_title":"","metadata":{"publisher":"Hindawi Publishing Corporation","grobid_abstract":"Introduction. Recombinant human thyroid stimulating hormone (rhTSH) is approved for preparation of thyroid remnant ablation with radioactive iodine (RAI) in low risk patients with well differentiated thyroid cancer (DTC). We studied the safety and efficacy of rhTSH preparation for RAI treatment of thyroid cancer patients with nodal metastatic disease. Methods. A retrospective analysis was performed on 108 patients with histopathologically confirmed nodal metastatic DTC, treated with initial RAI between January 1, 2000, and December 31, 2007. Within this selected group, 31 and 42 patients were prepared for initial and all subsequent RAI treatments by either thyroid hormone withdrawal (THW) or rhTSH protocols and were followed up for at least 3 years. Results. The response to initial treatment, classified as excellent, acceptable, or incomplete, was not different between the rhTSH group (57%, 21%, and 21%, resp.) and the THW group (39%, 13%, and 48%, resp.; = 0.052). There was no significant difference in the final clinical outcome between the groups. The rhTSH group received significantly fewer additional doses of RAI than the THW group (= 0.03). Conclusion. In patients with nodal-positive DTC, preparation for RAI with rhTSH is a safe and efficacious alternative to THW protocol.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Journal of Oncology","grobid_abstract_attachment_id":110560285},"translated_abstract":null,"internal_url":"https://www.academia.edu/113655886/Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease","translated_internal_url":"","created_at":"2024-01-17T13:11:56.547-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110560285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560285/thumbnails/1.jpg","file_name":"6496750.pdf","download_url":"https://www.academia.edu/attachments/110560285/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recombinant_Human_Thyroid_Stimulating_Ho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560285/6496750-libre.pdf?1705527034=\u0026response-content-disposition=attachment%3B+filename%3DRecombinant_Human_Thyroid_Stimulating_Ho.pdf\u0026Expires=1732525309\u0026Signature=ARYbGVxNVKC1PWCY0N1HohOZNR549jMb7DLlrVjNm5LTtCvg6sNpFtYEiLbPus1TgWkvMWKgJjV5lWTd8hUMd5cPlzglGoGDoc71iyXYzL~9L5RyVh883mF2JhC9J7s73wFU5LWnw0rk9FJbJuJCGitFYvEZ7E2ln~zLtDMVC0nqktm5nxTTM34aUcRgy~Gj7XBm95BEtA3Ewll8LTNZ6sZJd~mg7hj5pESMkQxXvQG6yjGXYvHP6cWIfdjjWZNmwG-W~HFUWIsDHsboFBLKtISTWt7Ff9QURjwULDz35cT117VU~RGNsAWj5VqXzMTPO0QdcXDEwxQckwHgS3iblg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[{"id":110560285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560285/thumbnails/1.jpg","file_name":"6496750.pdf","download_url":"https://www.academia.edu/attachments/110560285/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recombinant_Human_Thyroid_Stimulating_Ho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560285/6496750-libre.pdf?1705527034=\u0026response-content-disposition=attachment%3B+filename%3DRecombinant_Human_Thyroid_Stimulating_Ho.pdf\u0026Expires=1732525309\u0026Signature=ARYbGVxNVKC1PWCY0N1HohOZNR549jMb7DLlrVjNm5LTtCvg6sNpFtYEiLbPus1TgWkvMWKgJjV5lWTd8hUMd5cPlzglGoGDoc71iyXYzL~9L5RyVh883mF2JhC9J7s73wFU5LWnw0rk9FJbJuJCGitFYvEZ7E2ln~zLtDMVC0nqktm5nxTTM34aUcRgy~Gj7XBm95BEtA3Ewll8LTNZ6sZJd~mg7hj5pESMkQxXvQG6yjGXYvHP6cWIfdjjWZNmwG-W~HFUWIsDHsboFBLKtISTWt7Ff9QURjwULDz35cT117VU~RGNsAWj5VqXzMTPO0QdcXDEwxQckwHgS3iblg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":30649,"name":"Thyroid","url":"https://www.academia.edu/Documents/in/Thyroid"},{"id":51943,"name":"Thyroid Cancer","url":"https://www.academia.edu/Documents/in/Thyroid_Cancer"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":445233,"name":"Hormone","url":"https://www.academia.edu/Documents/in/Hormone"}],"urls":[{"id":38675436,"url":"https://doi.org/10.1155/2016/6496750"}]}, dispatcherData: dispatcherData }); 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Herein, we investigated the use of diffuse correlation spectroscopy (DCS) to monitor the dynamics of CBF during insulin-induced hypoglycemia in adults. Plasma glucose concentrations, cortisol levels, and changes in CBF were measured before and during hypoglycemia in 8 healthy subjects. Cerebral blood flow increased by 42% following insulin injection with a delay of 17 ± 10 min, while the onset of hypoglycemia symptoms was delayed by 24 ± 11 min. The findings suggest that the onset of CBF increments precedes the appearance of hypoglycemia symptoms in nondiabetic subjects with normal awareness to hypoglycemia, and DCS could be a valuable tool for investigating the role of CBF in hypoglycemia unawareness.","publication_date":{"day":4,"month":12,"year":2020,"errors":{}},"publication_name":"Scientific Reports","grobid_abstract_attachment_id":110560236},"translated_abstract":null,"internal_url":"https://www.academia.edu/113655885/Dynamic_response_of_cerebral_blood_flow_to_insulin_induced_hypoglycemia","translated_internal_url":"","created_at":"2024-01-17T13:11:56.155-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110560236,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560236/thumbnails/1.jpg","file_name":"s41598-020-77626-6.pdf","download_url":"https://www.academia.edu/attachments/110560236/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamic_response_of_cerebral_blood_flow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560236/s41598-020-77626-6-libre.pdf?1705527050=\u0026response-content-disposition=attachment%3B+filename%3DDynamic_response_of_cerebral_blood_flow.pdf\u0026Expires=1732525309\u0026Signature=WyumuxKtd2J4WxJzkB0iT77phZvkrERxhAF-mUN-EJOzd9MUoUAPrFjM5SknwLCQrHLnArEovbfIodaD72PUddtwS5RK4w9XfJ4xfMFOoyI8taakyK6UNu8lh2q1TtjkmXMQ7po3ow6o~oYVAUUqr3t6PSMOpiBknLMI3lPrrrJ1Kcen4mjlCaXjH4ekE3e-IE44st0SXVuwIdVQ4TLN0SWYgZSL6jkwXdpNFEh6yrN7fWiwKMUFAl4tbmfOEjbsmHY4tqbh8TGoFs5cFbJKM9laaeJ7mIBCr-ORUs7~qpE-NHMQbZsQLdIWEEWLA5-hBUOFIcYh-Bd3q-b60ewlwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dynamic_response_of_cerebral_blood_flow_to_insulin_induced_hypoglycemia","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[{"id":110560236,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560236/thumbnails/1.jpg","file_name":"s41598-020-77626-6.pdf","download_url":"https://www.academia.edu/attachments/110560236/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamic_response_of_cerebral_blood_flow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560236/s41598-020-77626-6-libre.pdf?1705527050=\u0026response-content-disposition=attachment%3B+filename%3DDynamic_response_of_cerebral_blood_flow.pdf\u0026Expires=1732525309\u0026Signature=WyumuxKtd2J4WxJzkB0iT77phZvkrERxhAF-mUN-EJOzd9MUoUAPrFjM5SknwLCQrHLnArEovbfIodaD72PUddtwS5RK4w9XfJ4xfMFOoyI8taakyK6UNu8lh2q1TtjkmXMQ7po3ow6o~oYVAUUqr3t6PSMOpiBknLMI3lPrrrJ1Kcen4mjlCaXjH4ekE3e-IE44st0SXVuwIdVQ4TLN0SWYgZSL6jkwXdpNFEh6yrN7fWiwKMUFAl4tbmfOEjbsmHY4tqbh8TGoFs5cFbJKM9laaeJ7mIBCr-ORUs7~qpE-NHMQbZsQLdIWEEWLA5-hBUOFIcYh-Bd3q-b60ewlwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":110560235,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560235/thumbnails/1.jpg","file_name":"s41598-020-77626-6.pdf","download_url":"https://www.academia.edu/attachments/110560235/download_file","bulk_download_file_name":"Dynamic_response_of_cerebral_blood_flow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560235/s41598-020-77626-6-libre.pdf?1705527038=\u0026response-content-disposition=attachment%3B+filename%3DDynamic_response_of_cerebral_blood_flow.pdf\u0026Expires=1732525309\u0026Signature=W4C24HAEUxjtnXb9WGHUXCemwFKVBlwM9q666x67BIaDovXuJgyke3cvus0tzeuw~1rdJrFUwBoL0X6umJiZJ5X3gLBu1NXHnGa4Q9wYG6FNKdIFoKjxePQK8UXRKCd3l6vpbrjYu9KYApx2c3kGqWhXN98A6uyNgkWA0ex77Eks0GwTLfOxcG8~QsZ5pGO~IUB1aEwjfFVOqAcXG6kgqgCExArR1BXsrm~B5AsOxu6TYrfeLaQhtxKb75z9p-1VfkQ3Go~O-dNwh7XeknaHFNPqoUFxx03ALNFAU~9AwCaPCcE2c-Tvzt4DO-Q5aQoNECw5~AJJmLRtCqvKH1h6Eg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":116895,"name":"Hypoglycemia","url":"https://www.academia.edu/Documents/in/Hypoglycemia"},{"id":970066,"name":"Cerebral Blood Flow","url":"https://www.academia.edu/Documents/in/Cerebral_Blood_Flow"}],"urls":[{"id":38675435,"url":"https://www.nature.com/articles/s41598-020-77626-6.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655883/ACTH_Dependent_Cushing_Syndrome_in_Metastatic_Acinic_Cell_Carcinoma_A_Poor_Prognostic_Factor"><img alt="Research paper thumbnail of ACTH-Dependent Cushing Syndrome in Metastatic Acinic Cell Carcinoma: A Poor Prognostic Factor" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655883/ACTH_Dependent_Cushing_Syndrome_in_Metastatic_Acinic_Cell_Carcinoma_A_Poor_Prognostic_Factor">ACTH-Dependent Cushing Syndrome in Metastatic Acinic Cell Carcinoma: A Poor Prognostic Factor</a></div><div class="wp-workCard_item"><span>Annals of Internal Medicine: Clinical Cases</span><span>, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655883; 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The phe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. The phenotypic effect of a recently discovered hyper-functional ADCY6 S674 variant is unclear. 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655898/Factor_V_Leiden_mutation_prothrombin_gene_mutation_and_deficiencies_in_coagulation_inhibitors_associated_with_Budd_Chiari_syndrome_and_portal_vein_thrombosis_results_of_a_case_control_study"><img alt="Research paper thumbnail of Factor V Leiden mutation, prothrombin gene mutation and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis : results of a case-control study" class="work-thumbnail" src="https://attachments.academia-assets.com/110560246/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c18eb0828d770ebf0341bbe218fb9fc6" } } $('.js-work-strip[data-work-id=113655898]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655898,"title":"Factor V Leiden mutation, prothrombin gene mutation and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis : results of a case-control study","translated_title":"","metadata":{"publisher":"American Society of Hematology","grobid_abstract":"In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We compared 43 BCS patients and 92 PVT patients with 474 population-based controls. The relative risk of BCS was 11.3 (95% CI 4.8-26.5) for individuals with factor V Leiden mutation, 2.1(95% CI 0.4-9.6) for those with prothrombin gene mutation, and 6.8 (95% CI 1.9-24.4) for those with protein C deficiency. The relative risk of PVT was 2.7 (95% CI 1.1-6.9) for individuals with factor V Leiden mutation, 1.4 (95% CI 0.4-5.2) for those with prothrombin gene mutation, and 4.6 (95% CI 1.5-14.1) for those with protein C deficiency. The relative risk of BCS or PVT was not increased in the presence of inherited protein S or antithrombin deficiency. Concurrence of either acquired or inherited thrombotic risk factors was observed in 26% of the BCS patients and 37% of the PVT patients. We conclude that factor V Leiden mutation and hereditary protein C deficiency appear to be important risk factors for BCS and PVT. Although the prevalence of the prothrombin gene mutation was increased, it was not found to be a significant risk factor for BCS and PVT. 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class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655895/D_dimeer_en_de_diagnostiek_van_diep_veneuze_trombose_vergelijkend_onderzoek_van_13_D_dimeer_bepalingen_bij_99_pati%C3%ABnten_met_klinische_verdenking_op_diepe_veneuze_trombose">D-dimeer en de diagnostiek van diep veneuze trombose: vergelijkend onderzoek van 13 D-dimeer bepalingen bij 99 patiënten met klinische verdenking op diepe veneuze trombose</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Item does not contain fulltex</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655895"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655895"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655895; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655895]").text(description); $(".js-view-count[data-work-id=113655895]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x 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Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[],"research_interests":[{"id":1236,"name":"Art","url":"https://www.academia.edu/Documents/in/Art"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":38675446,"url":"https://repository.ubn.ru.nl/handle/2066/157359"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655894"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655894/Management_of_Hypoparathyroidism"><img alt="Research paper thumbnail of Management of Hypoparathyroidism" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655894/Management_of_Hypoparathyroidism">Management of Hypoparathyroidism</a></div><div class="wp-workCard_item"><span>Journal of Bone and Mineral Research</span><span>, Oct 31, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the prese...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the presence of a low or inappropriately normal parathyroid hormone level. HypoPT is most commonly seen after neck surgery, which accounts for approximately 75% of cases, whereas approximately 25% have HypoPT due to nonsurgical causes. In both groups of patients, conventional therapy includes calcium and active vitamin D analogue therapy aiming to maintain serum calcium concentration in the low normal or just below the normal reference range and normalize serum phosphorus, magnesium concentrations, and urine calcium levels. The limitations of conventional therapy include wide fluctuations in serum calcium, high pill burden, poor quality of life, and renal complications. Parathyroid hormone (PTH) replacement therapy may improve the biochemical profile in those in whom conventional therapy proves unsatisfactory. Based on a systematic review and meta‐analysis of the literature, the panel made a graded recommendation suggesting conventional therapy as first line therapy rather than administration of PTH (weak recommendation, low quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers use of PTH. Because pregnancy and lactation are associated with changes in calcium homeostasis, close monitoring is required during these periods with appropriate adjustment of calcium and active vitamin D analogue therapy to ensure that serum calcium remains in the mid to low normal reference range in order to avoid maternal and fetal complications. Emerging therapies include molecules with prolonged PTH action as well as different mechanisms of action that may significantly enhance drug efficacy and safety. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655894"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655894"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655894; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655894]").text(description); $(".js-view-count[data-work-id=113655894]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655894; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655894']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655894, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113655894]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655894,"title":"Management of Hypoparathyroidism","translated_title":"","metadata":{"abstract":"ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the presence of a low or inappropriately normal parathyroid hormone level. HypoPT is most commonly seen after neck surgery, which accounts for approximately 75% of cases, whereas approximately 25% have HypoPT due to nonsurgical causes. In both groups of patients, conventional therapy includes calcium and active vitamin D analogue therapy aiming to maintain serum calcium concentration in the low normal or just below the normal reference range and normalize serum phosphorus, magnesium concentrations, and urine calcium levels. The limitations of conventional therapy include wide fluctuations in serum calcium, high pill burden, poor quality of life, and renal complications. Parathyroid hormone (PTH) replacement therapy may improve the biochemical profile in those in whom conventional therapy proves unsatisfactory. Based on a systematic review and meta‐analysis of the literature, the panel made a graded recommendation suggesting conventional therapy as first line therapy rather than administration of PTH (weak recommendation, low quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers use of PTH. Because pregnancy and lactation are associated with changes in calcium homeostasis, close monitoring is required during these periods with appropriate adjustment of calcium and active vitamin D analogue therapy to ensure that serum calcium remains in the mid to low normal reference range in order to avoid maternal and fetal complications. Emerging therapies include molecules with prolonged PTH action as well as different mechanisms of action that may significantly enhance drug efficacy and safety. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","publisher":"Wiley-Blackwell","publication_date":{"day":31,"month":10,"year":2022,"errors":{}},"publication_name":"Journal of Bone and Mineral Research"},"translated_abstract":"ABSTRACTHypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia in the presence of a low or inappropriately normal parathyroid hormone level. HypoPT is most commonly seen after neck surgery, which accounts for approximately 75% of cases, whereas approximately 25% have HypoPT due to nonsurgical causes. In both groups of patients, conventional therapy includes calcium and active vitamin D analogue therapy aiming to maintain serum calcium concentration in the low normal or just below the normal reference range and normalize serum phosphorus, magnesium concentrations, and urine calcium levels. The limitations of conventional therapy include wide fluctuations in serum calcium, high pill burden, poor quality of life, and renal complications. Parathyroid hormone (PTH) replacement therapy may improve the biochemical profile in those in whom conventional therapy proves unsatisfactory. Based on a systematic review and meta‐analysis of the literature, the panel made a graded recommendation suggesting conventional therapy as first line therapy rather than administration of PTH (weak recommendation, low quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers use of PTH. Because pregnancy and lactation are associated with changes in calcium homeostasis, close monitoring is required during these periods with appropriate adjustment of calcium and active vitamin D analogue therapy to ensure that serum calcium remains in the mid to low normal reference range in order to avoid maternal and fetal complications. Emerging therapies include molecules with prolonged PTH action as well as different mechanisms of action that may significantly enhance drug efficacy and safety. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","internal_url":"https://www.academia.edu/113655894/Management_of_Hypoparathyroidism","translated_internal_url":"","created_at":"2024-01-17T13:11:58.249-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Management_of_Hypoparathyroidism","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":203383,"name":"Parathyroid Hormone","url":"https://www.academia.edu/Documents/in/Parathyroid_Hormone"},{"id":438516,"name":"Bone Mineral Density","url":"https://www.academia.edu/Documents/in/Bone_Mineral_Density"},{"id":2343787,"name":"Hypoparathyroidism","url":"https://www.academia.edu/Documents/in/Hypoparathyroidism"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":38675445,"url":"https://doi.org/10.1002/jbmr.4716"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655893"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655893/Retinotopic_organization_of_the_primary_visual_cortex_before_and_after_pharmacological_treatment_for_a_large_prolactinoma_with_compression_of_the_optic_chiasm"><img alt="Research paper thumbnail of Retinotopic organization of the primary visual cortex before and after pharmacological treatment for a large prolactinoma with compression of the optic chiasm" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655893/Retinotopic_organization_of_the_primary_visual_cortex_before_and_after_pharmacological_treatment_for_a_large_prolactinoma_with_compression_of_the_optic_chiasm">Retinotopic organization of the primary visual cortex before and after pharmacological treatment for a large prolactinoma with compression of the optic chiasm</a></div><div class="wp-workCard_item"><span>Journal of Vision</span><span>, Sep 1, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have visual deficits, typically bilateral hemianopsia, because of chiasmal compression. Treatment of macroadenomas is usually successful, and thus such patients provide a unique opportunity for studying neuroplasticity in the human visual system and its consequences for vision. This case study focuses on patient BS, a 48-year-old man, who had a large prolactinoma, a common pituitary tumor, and, as a consequence, a severe visual field loss. We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of primary visual cortex (V1) of patient BS before and after successful treatment of his prolactinoma with cabergoline over the course of 13 months. In addition, we used the same fMRI protocol to examine the organization of V1 in a healthy age- and gender-matched control participant with normal vision. Humphrey&#39;s perimetry was used to assess the integrity of the visual fields, before and after the completion of treatment for patient BS, and over two successive scans in the healthy control. The Humphrey field exam revealed significant visual improvement after treatment and this recovery was accompanied by substantial changes in V1 activation. Before the start of treatment, the amount of cortical tissue in V1 which was activated by the retinotopic stimuli was only 21% that of the healthy control participant. After treatment, the amount of activation normalized to approximately 90% of that of the control participant. The organization of retinotopic representations in V1 also normalized after treatment. These results illustrate that the visual system is capable of repair following conservative medical treatment, opening the door for assessing the effects of compression on different components of the optic nerve and tract. Meeting abstract presented at VSS 2015.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655893"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655893"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655893; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655893]").text(description); $(".js-view-count[data-work-id=113655893]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655893; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655893']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655893, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113655893]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655893,"title":"Retinotopic organization of the primary visual cortex before and after pharmacological treatment for a large prolactinoma with compression of the optic chiasm","translated_title":"","metadata":{"abstract":"Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have visual deficits, typically bilateral hemianopsia, because of chiasmal compression. Treatment of macroadenomas is usually successful, and thus such patients provide a unique opportunity for studying neuroplasticity in the human visual system and its consequences for vision. This case study focuses on patient BS, a 48-year-old man, who had a large prolactinoma, a common pituitary tumor, and, as a consequence, a severe visual field loss. We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of primary visual cortex (V1) of patient BS before and after successful treatment of his prolactinoma with cabergoline over the course of 13 months. In addition, we used the same fMRI protocol to examine the organization of V1 in a healthy age- and gender-matched control participant with normal vision. Humphrey\u0026#39;s perimetry was used to assess the integrity of the visual fields, before and after the completion of treatment for patient BS, and over two successive scans in the healthy control. 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Meeting abstract presented at VSS 2015.","publisher":"Association for Research in Vision and Ophthalmology","publication_date":{"day":1,"month":9,"year":2015,"errors":{}},"publication_name":"Journal of Vision"},"translated_abstract":"Patients suffering from pituitary macroadenomas - pituitary tumors larger than 10mm - often have visual deficits, typically bilateral hemianopsia, because of chiasmal compression. Treatment of macroadenomas is usually successful, and thus such patients provide a unique opportunity for studying neuroplasticity in the human visual system and its consequences for vision. This case study focuses on patient BS, a 48-year-old man, who had a large prolactinoma, a common pituitary tumor, and, as a consequence, a severe visual field loss. We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of primary visual cortex (V1) of patient BS before and after successful treatment of his prolactinoma with cabergoline over the course of 13 months. In addition, we used the same fMRI protocol to examine the organization of V1 in a healthy age- and gender-matched control participant with normal vision. Humphrey\u0026#39;s perimetry was used to assess the integrity of the visual fields, before and after the completion of treatment for patient BS, and over two successive scans in the healthy control. The Humphrey field exam revealed significant visual improvement after treatment and this recovery was accompanied by substantial changes in V1 activation. Before the start of treatment, the amount of cortical tissue in V1 which was activated by the retinotopic stimuli was only 21% that of the healthy control participant. After treatment, the amount of activation normalized to approximately 90% of that of the control participant. The organization of retinotopic representations in V1 also normalized after treatment. These results illustrate that the visual system is capable of repair following conservative medical treatment, opening the door for assessing the effects of compression on different components of the optic nerve and tract. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655892"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655892/Central_hypothyroidism"><img alt="Research paper thumbnail of Central hypothyroidism" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655892/Central_hypothyroidism">Central hypothyroidism</a></div><div class="wp-workCard_item"><span>PubMed</span><span>, Jun 1, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655892"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655892"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655892; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655891"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655891/_Generalized_histoplasmosis_due_to_endogenous_reactivation_of_a_latent_infection_in_an_HIV_seronegative_man_"><img alt="Research paper thumbnail of [Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man]" class="work-thumbnail" src="https://attachments.academia-assets.com/110560288/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655891/_Generalized_histoplasmosis_due_to_endogenous_reactivation_of_a_latent_infection_in_an_HIV_seronegative_man_">[Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man]</a></div><div class="wp-workCard_item"><span>PubMed</span><span>, Jul 15, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duratio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. This case report illustrates that disseminated histoplasmosis may mimic Crohn's disease leading to a delay in the diagnosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a55634cf05f36524fad1635ef7e5927" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560288,"asset_id":113655891,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560288/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655891"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655891"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655891; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655891]").text(description); $(".js-view-count[data-work-id=113655891]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655891; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655891']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655891, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1a55634cf05f36524fad1635ef7e5927" } } $('.js-work-strip[data-work-id=113655891]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655891,"title":"[Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man]","translated_title":"","metadata":{"abstract":"A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. This case report illustrates that disseminated histoplasmosis may mimic Crohn's disease leading to a delay in the diagnosis.","publication_date":{"day":15,"month":7,"year":1995,"errors":{}},"publication_name":"PubMed"},"translated_abstract":"A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655890"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655890/Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey"><img alt="Research paper thumbnail of Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655890/Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey">Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey</a></div><div class="wp-workCard_item"><span>Journal of Bone and Mineral Research</span><span>, Nov 14, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired quality of life (QoL). The goals of management for chronic HypoPT include improvement in QoL and the prevention of both hypo‐ and hypercalcemia symptoms and long‐term complications. Several groups have provided consensus statements and guidelines on the management of HypoPT; however, due to limited evidence, these recommendations have largely been based on literature reviews, expert opinion, and consensus statements. The objective of this study was to use a systematic approach to describe current practice for the initial assessment and follow‐up of patients with chronic HypoPT. We developed a survey asking experts in the field to select the responses that best reflect their current practice. The survey found no differences in responses between nonsurgical and postsurgical patient assessment. For new patients, respondents usually performed an assessment of serum lab profile (calcium [either albumin‐adjusted or ionized], magnesium, creatinine, phosphate, 25‐hydroxyvitamin D), 24‐hour urine (creatinine, calcium), and a renal ultrasound to evaluate for the presence of nephrocalcinosis or nephrolithiasis. For follow‐up patients, most respondents perform blood tests and urine tests every 6 months or less frequently. The reported clinical practice patterns for monitoring for complications of chronic HypoPT vary considerably among respondents. Based on the responses in this systematic expert practice survey, we provide practice suggestions for initial assessment and follow‐up of patients with chronic HypoPT. In addition, we highlight areas with significant variation in practice and identify important areas for future research. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655890"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655890"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655890; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113655890]").text(description); $(".js-view-count[data-work-id=113655890]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113655890; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113655890']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113655890, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113655890]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113655890,"title":"Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey","translated_title":"","metadata":{"abstract":"ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired quality of life (QoL). The goals of management for chronic HypoPT include improvement in QoL and the prevention of both hypo‐ and hypercalcemia symptoms and long‐term complications. Several groups have provided consensus statements and guidelines on the management of HypoPT; however, due to limited evidence, these recommendations have largely been based on literature reviews, expert opinion, and consensus statements. The objective of this study was to use a systematic approach to describe current practice for the initial assessment and follow‐up of patients with chronic HypoPT. We developed a survey asking experts in the field to select the responses that best reflect their current practice. The survey found no differences in responses between nonsurgical and postsurgical patient assessment. For new patients, respondents usually performed an assessment of serum lab profile (calcium [either albumin‐adjusted or ionized], magnesium, creatinine, phosphate, 25‐hydroxyvitamin D), 24‐hour urine (creatinine, calcium), and a renal ultrasound to evaluate for the presence of nephrocalcinosis or nephrolithiasis. For follow‐up patients, most respondents perform blood tests and urine tests every 6 months or less frequently. The reported clinical practice patterns for monitoring for complications of chronic HypoPT vary considerably among respondents. Based on the responses in this systematic expert practice survey, we provide practice suggestions for initial assessment and follow‐up of patients with chronic HypoPT. In addition, we highlight areas with significant variation in practice and identify important areas for future research. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","publisher":"Wiley-Blackwell","publication_date":{"day":14,"month":11,"year":2022,"errors":{}},"publication_name":"Journal of Bone and Mineral Research"},"translated_abstract":"ABSTRACTChronic hypoparathyroidism (HypoPT) is associated with significant morbidity and impaired quality of life (QoL). The goals of management for chronic HypoPT include improvement in QoL and the prevention of both hypo‐ and hypercalcemia symptoms and long‐term complications. Several groups have provided consensus statements and guidelines on the management of HypoPT; however, due to limited evidence, these recommendations have largely been based on literature reviews, expert opinion, and consensus statements. The objective of this study was to use a systematic approach to describe current practice for the initial assessment and follow‐up of patients with chronic HypoPT. We developed a survey asking experts in the field to select the responses that best reflect their current practice. The survey found no differences in responses between nonsurgical and postsurgical patient assessment. For new patients, respondents usually performed an assessment of serum lab profile (calcium [either albumin‐adjusted or ionized], magnesium, creatinine, phosphate, 25‐hydroxyvitamin D), 24‐hour urine (creatinine, calcium), and a renal ultrasound to evaluate for the presence of nephrocalcinosis or nephrolithiasis. For follow‐up patients, most respondents perform blood tests and urine tests every 6 months or less frequently. The reported clinical practice patterns for monitoring for complications of chronic HypoPT vary considerably among respondents. Based on the responses in this systematic expert practice survey, we provide practice suggestions for initial assessment and follow‐up of patients with chronic HypoPT. In addition, we highlight areas with significant variation in practice and identify important areas for future research. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","internal_url":"https://www.academia.edu/113655890/Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey","translated_internal_url":"","created_at":"2024-01-17T13:11:57.425-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Initial_Assessment_and_Monitoring_of_Patients_with_Chronic_Hypoparathyroidism_A_Systematic_Current_Practice_Survey","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":52836,"name":"Clinical Practice","url":"https://www.academia.edu/Documents/in/Clinical_Practice"},{"id":221411,"name":"Systematic review","url":"https://www.academia.edu/Documents/in/Systematic_review"},{"id":438516,"name":"Bone Mineral Density","url":"https://www.academia.edu/Documents/in/Bone_Mineral_Density"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":38675441,"url":"https://doi.org/10.1002/jbmr.4698"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655889"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655889/Consensus_Recommendations_for_the_Diagnosis_and_Management_of_Well_Differentiated_Gastroenterohepatic_Neuroendocrine_Tumours_A_Revised_Statement_from_a_Canadian_National_Expert_Group"><img alt="Research paper thumbnail of Consensus Recommendations for the Diagnosis and Management of Well-Differentiated Gastroenterohepatic Neuroendocrine Tumours: A Revised Statement from a Canadian National Expert Group" class="work-thumbnail" src="https://attachments.academia-assets.com/110560243/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655889/Consensus_Recommendations_for_the_Diagnosis_and_Management_of_Well_Differentiated_Gastroenterohepatic_Neuroendocrine_Tumours_A_Revised_Statement_from_a_Canadian_National_Expert_Group">Consensus Recommendations for the Diagnosis and Management of Well-Differentiated Gastroenterohepatic Neuroendocrine Tumours: A Revised Statement from a Canadian National Expert Group</a></div><div class="wp-workCard_item"><span>Current Oncology</span><span>, Jun 1, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9aacdd13aeeb600ae2dddca354e4abef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560243,"asset_id":113655889,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560243/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655889"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655889"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655889; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655888"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655888/Stress_Pathways_to_Spontaneous_Preterm_Birth_The_Role_of_Stressors_Psychological_Distress_and_Stress_Hormones"><img alt="Research paper thumbnail of Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones" class="work-thumbnail" src="https://attachments.academia-assets.com/110560241/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655888/Stress_Pathways_to_Spontaneous_Preterm_Birth_The_Role_of_Stressors_Psychological_Distress_and_Stress_Hormones">Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones</a></div><div class="wp-workCard_item"><span>American Journal of Epidemiology</span><span>, Apr 10, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0ccc056f0e8fc5b79b8b28420dad28d5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110560241,"asset_id":113655888,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110560241/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655888"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655888"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655888; 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In addition, a nested case-control analysis (207 cases, 444 controls) was used to explore potential biologic pathways by analyzing maternal plasma corticotrophin-releasing hormone (CRH), placental histopathology, and (in a subset) maternal hair cortisol. Among the large number of stress and distress measures studied, only pregnancy-related anxiety was consistently and independently associated with spontaneous preterm birth (for values above the median, adjusted odds ratio ¼ 1.8 (95% confidence interval: 1.3, 2.4)), with a dose-response relation across quartiles. The maternal plasma CRH concentration was significantly higher in cases than in controls in crude analyses but not after adjustment (for concentrations above the median, adjusted odds ratio ¼ 1.1 (95% confidence interval: 0.8, 1.6)). In the subgroup (n ¼ 117) of participants with a sufficient maternal hair sample, hair cortisol was positively associated with gestational age. Neither maternal plasma CRH, hair cortisol, nor placental histopathologic features of infection/inflammation, infarction, or maternal vasculopathy were significantly associated with pregnancy-related anxiety or any other stress or distress measure. 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}); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655887"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655887/Opioid_induced_endocrinopathies"><img alt="Research paper thumbnail of Opioid-induced endocrinopathies" class="work-thumbnail" src="https://attachments.academia-assets.com/110560239/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655887/Opioid_induced_endocrinopathies">Opioid-induced endocrinopathies</a></div><div class="wp-workCard_item"><span>The Lancet Diabetes & Endocrinology</span><span>, 2020</span></div><div class="wp-workCard_item 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{"id":113655887,"title":"Opioid-induced endocrinopathies","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"ΤAs the use of opioids is becoming a global epidemic and has led to a rise in expanding, so has the occurrence and recognition of their impact consequences on the endocrine system. Nonetheless, opioid-induced endocrinopathies still remain under-diagnosed, mainly due to symptom under-reporting by patients and lack of awareness in clinicians. Hypogonadism is the most well recognised consequence but These include hypogonadism, inhibitory effects on the hypothalamo-pituitary-adrenal axis and negative impact on bone health also require attention.. Hyperprolactinaemia may also be detected, whereas, clinically relevant thyroid dysfunction has not been identified. EThe effects on other hormones have not been as yet clearly defined. At present, consensus or evidence-based guidelines on how to diagnose and manage these endocrinopathies are lacking. ANonetheless, assessment of gonadal and adrenal function (particularly if in the presence of high index of clinical suspicion), and, as well as evaluation of bone health are advised in these patients. Discontinuation or reduction of the opioid dose and appropriate hormone replacement are management approaches for hypogonadism and hypoadrenalism. Further research is needed to fully elucidate the impact of opioids at all levels of the endocrine system and the optimal management of their consequences.Further research facilitating the development of evidence-based guidelines on the diagnosis and optimal management of opioid-induced endocrinopathies is eagerly awaited.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"The Lancet Diabetes \u0026 Endocrinology","grobid_abstract_attachment_id":110560239},"translated_abstract":null,"internal_url":"https://www.academia.edu/113655887/Opioid_induced_endocrinopathies","translated_internal_url":"","created_at":"2024-01-17T13:11:56.834-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110560239,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560239/thumbnails/1.jpg","file_name":"Opioid_induced_endocrinopathies_revised_final.pdf","download_url":"https://www.academia.edu/attachments/110560239/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Opioid_induced_endocrinopathies.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560239/Opioid_induced_endocrinopathies_revised_final-libre.pdf?1705527048=\u0026response-content-disposition=attachment%3B+filename%3DOpioid_induced_endocrinopathies.pdf\u0026Expires=1732525309\u0026Signature=S9nZXov4o7~JYS1A9tWWgRI0JZ5~G2oam4~J-sgwG4CNxy4iey8u3p6HxMdZjZ0JPge-mDbR~KORNlEoqgoSEKszImscqowcJZzc6HzEAUWQ9T4sK2CQ9OwIq08fjV36vIm99cHtNUpBb6BaJev~8zSdpYcFTowTeWBGPKBYtDJY2qoJE0sBx7hEAAn9-q6LfRAXNRaQDKqSBhfNsHqN~EiIOpUsnwbWqTl2wbCUBAeLc-88u~VfRq1EmoJvaLzJYjIgUBx4oQqrMQCJ4ZXXMST8TwXZvY3bWsIp9~wHe-DuNjPMS7V7lzxn-WAkfpbZ5TOYG22xW1Q~VRMYIwx9~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Opioid_induced_endocrinopathies","translated_slug":"","page_count":41,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van 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System","url":"https://www.academia.edu/Documents/in/Endocrine_System"},{"id":3331893,"name":"discontinuation","url":"https://www.academia.edu/Documents/in/discontinuation"}],"urls":[{"id":38675437,"url":"http://pure-oai.bham.ac.uk/ws/files/68274341/Opioid_induced_endocrinopathies_revised_final.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655886"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655886/Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease"><img alt="Research paper thumbnail of Recombinant Human Thyroid Stimulating Hormone versus Thyroid Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/110560285/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655886/Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease">Recombinant Human Thyroid Stimulating Hormone versus Thyroid Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease</a></div><div class="wp-workCard_item"><span>Journal of Oncology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease","translated_title":"","metadata":{"publisher":"Hindawi Publishing Corporation","grobid_abstract":"Introduction. Recombinant human thyroid stimulating hormone (rhTSH) is approved for preparation of thyroid remnant ablation with radioactive iodine (RAI) in low risk patients with well differentiated thyroid cancer (DTC). We studied the safety and efficacy of rhTSH preparation for RAI treatment of thyroid cancer patients with nodal metastatic disease. Methods. A retrospective analysis was performed on 108 patients with histopathologically confirmed nodal metastatic DTC, treated with initial RAI between January 1, 2000, and December 31, 2007. Within this selected group, 31 and 42 patients were prepared for initial and all subsequent RAI treatments by either thyroid hormone withdrawal (THW) or rhTSH protocols and were followed up for at least 3 years. Results. The response to initial treatment, classified as excellent, acceptable, or incomplete, was not different between the rhTSH group (57%, 21%, and 21%, resp.) and the THW group (39%, 13%, and 48%, resp.; = 0.052). There was no significant difference in the final clinical outcome between the groups. The rhTSH group received significantly fewer additional doses of RAI than the THW group (= 0.03). Conclusion. In patients with nodal-positive DTC, preparation for RAI with rhTSH is a safe and efficacious alternative to THW protocol.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Journal of Oncology","grobid_abstract_attachment_id":110560285},"translated_abstract":null,"internal_url":"https://www.academia.edu/113655886/Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease","translated_internal_url":"","created_at":"2024-01-17T13:11:56.547-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110560285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560285/thumbnails/1.jpg","file_name":"6496750.pdf","download_url":"https://www.academia.edu/attachments/110560285/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recombinant_Human_Thyroid_Stimulating_Ho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560285/6496750-libre.pdf?1705527034=\u0026response-content-disposition=attachment%3B+filename%3DRecombinant_Human_Thyroid_Stimulating_Ho.pdf\u0026Expires=1732525309\u0026Signature=ARYbGVxNVKC1PWCY0N1HohOZNR549jMb7DLlrVjNm5LTtCvg6sNpFtYEiLbPus1TgWkvMWKgJjV5lWTd8hUMd5cPlzglGoGDoc71iyXYzL~9L5RyVh883mF2JhC9J7s73wFU5LWnw0rk9FJbJuJCGitFYvEZ7E2ln~zLtDMVC0nqktm5nxTTM34aUcRgy~Gj7XBm95BEtA3Ewll8LTNZ6sZJd~mg7hj5pESMkQxXvQG6yjGXYvHP6cWIfdjjWZNmwG-W~HFUWIsDHsboFBLKtISTWt7Ff9QURjwULDz35cT117VU~RGNsAWj5VqXzMTPO0QdcXDEwxQckwHgS3iblg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Recombinant_Human_Thyroid_Stimulating_Hormone_versus_Thyroid_Hormone_Withdrawal_for_Radioactive_Iodine_Treatment_of_Differentiated_Thyroid_Cancer_with_Nodal_Metastatic_Disease","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[{"id":110560285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560285/thumbnails/1.jpg","file_name":"6496750.pdf","download_url":"https://www.academia.edu/attachments/110560285/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recombinant_Human_Thyroid_Stimulating_Ho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560285/6496750-libre.pdf?1705527034=\u0026response-content-disposition=attachment%3B+filename%3DRecombinant_Human_Thyroid_Stimulating_Ho.pdf\u0026Expires=1732525309\u0026Signature=ARYbGVxNVKC1PWCY0N1HohOZNR549jMb7DLlrVjNm5LTtCvg6sNpFtYEiLbPus1TgWkvMWKgJjV5lWTd8hUMd5cPlzglGoGDoc71iyXYzL~9L5RyVh883mF2JhC9J7s73wFU5LWnw0rk9FJbJuJCGitFYvEZ7E2ln~zLtDMVC0nqktm5nxTTM34aUcRgy~Gj7XBm95BEtA3Ewll8LTNZ6sZJd~mg7hj5pESMkQxXvQG6yjGXYvHP6cWIfdjjWZNmwG-W~HFUWIsDHsboFBLKtISTWt7Ff9QURjwULDz35cT117VU~RGNsAWj5VqXzMTPO0QdcXDEwxQckwHgS3iblg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":30649,"name":"Thyroid","url":"https://www.academia.edu/Documents/in/Thyroid"},{"id":51943,"name":"Thyroid Cancer","url":"https://www.academia.edu/Documents/in/Thyroid_Cancer"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":445233,"name":"Hormone","url":"https://www.academia.edu/Documents/in/Hormone"}],"urls":[{"id":38675436,"url":"https://doi.org/10.1155/2016/6496750"}]}, dispatcherData: dispatcherData }); 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Herein, we investigated the use of diffuse correlation spectroscopy (DCS) to monitor the dynamics of CBF during insulin-induced hypoglycemia in adults. Plasma glucose concentrations, cortisol levels, and changes in CBF were measured before and during hypoglycemia in 8 healthy subjects. Cerebral blood flow increased by 42% following insulin injection with a delay of 17 ± 10 min, while the onset of hypoglycemia symptoms was delayed by 24 ± 11 min. The findings suggest that the onset of CBF increments precedes the appearance of hypoglycemia symptoms in nondiabetic subjects with normal awareness to hypoglycemia, and DCS could be a valuable tool for investigating the role of CBF in hypoglycemia unawareness.","publication_date":{"day":4,"month":12,"year":2020,"errors":{}},"publication_name":"Scientific Reports","grobid_abstract_attachment_id":110560236},"translated_abstract":null,"internal_url":"https://www.academia.edu/113655885/Dynamic_response_of_cerebral_blood_flow_to_insulin_induced_hypoglycemia","translated_internal_url":"","created_at":"2024-01-17T13:11:56.155-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36470223,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110560236,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560236/thumbnails/1.jpg","file_name":"s41598-020-77626-6.pdf","download_url":"https://www.academia.edu/attachments/110560236/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamic_response_of_cerebral_blood_flow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560236/s41598-020-77626-6-libre.pdf?1705527050=\u0026response-content-disposition=attachment%3B+filename%3DDynamic_response_of_cerebral_blood_flow.pdf\u0026Expires=1732525309\u0026Signature=WyumuxKtd2J4WxJzkB0iT77phZvkrERxhAF-mUN-EJOzd9MUoUAPrFjM5SknwLCQrHLnArEovbfIodaD72PUddtwS5RK4w9XfJ4xfMFOoyI8taakyK6UNu8lh2q1TtjkmXMQ7po3ow6o~oYVAUUqr3t6PSMOpiBknLMI3lPrrrJ1Kcen4mjlCaXjH4ekE3e-IE44st0SXVuwIdVQ4TLN0SWYgZSL6jkwXdpNFEh6yrN7fWiwKMUFAl4tbmfOEjbsmHY4tqbh8TGoFs5cFbJKM9laaeJ7mIBCr-ORUs7~qpE-NHMQbZsQLdIWEEWLA5-hBUOFIcYh-Bd3q-b60ewlwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dynamic_response_of_cerebral_blood_flow_to_insulin_induced_hypoglycemia","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":36470223,"first_name":"Stan","middle_initials":"","last_name":"Van Uum","page_name":"StanVanUum","domain_name":"independent","created_at":"2015-10-18T13:32:55.808-07:00","display_name":"Stan Van Uum","url":"https://independent.academia.edu/StanVanUum"},"attachments":[{"id":110560236,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560236/thumbnails/1.jpg","file_name":"s41598-020-77626-6.pdf","download_url":"https://www.academia.edu/attachments/110560236/download_file?st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&st=MTczMjUyMTcwOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamic_response_of_cerebral_blood_flow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560236/s41598-020-77626-6-libre.pdf?1705527050=\u0026response-content-disposition=attachment%3B+filename%3DDynamic_response_of_cerebral_blood_flow.pdf\u0026Expires=1732525309\u0026Signature=WyumuxKtd2J4WxJzkB0iT77phZvkrERxhAF-mUN-EJOzd9MUoUAPrFjM5SknwLCQrHLnArEovbfIodaD72PUddtwS5RK4w9XfJ4xfMFOoyI8taakyK6UNu8lh2q1TtjkmXMQ7po3ow6o~oYVAUUqr3t6PSMOpiBknLMI3lPrrrJ1Kcen4mjlCaXjH4ekE3e-IE44st0SXVuwIdVQ4TLN0SWYgZSL6jkwXdpNFEh6yrN7fWiwKMUFAl4tbmfOEjbsmHY4tqbh8TGoFs5cFbJKM9laaeJ7mIBCr-ORUs7~qpE-NHMQbZsQLdIWEEWLA5-hBUOFIcYh-Bd3q-b60ewlwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":110560235,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110560235/thumbnails/1.jpg","file_name":"s41598-020-77626-6.pdf","download_url":"https://www.academia.edu/attachments/110560235/download_file","bulk_download_file_name":"Dynamic_response_of_cerebral_blood_flow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110560235/s41598-020-77626-6-libre.pdf?1705527038=\u0026response-content-disposition=attachment%3B+filename%3DDynamic_response_of_cerebral_blood_flow.pdf\u0026Expires=1732525309\u0026Signature=W4C24HAEUxjtnXb9WGHUXCemwFKVBlwM9q666x67BIaDovXuJgyke3cvus0tzeuw~1rdJrFUwBoL0X6umJiZJ5X3gLBu1NXHnGa4Q9wYG6FNKdIFoKjxePQK8UXRKCd3l6vpbrjYu9KYApx2c3kGqWhXN98A6uyNgkWA0ex77Eks0GwTLfOxcG8~QsZ5pGO~IUB1aEwjfFVOqAcXG6kgqgCExArR1BXsrm~B5AsOxu6TYrfeLaQhtxKb75z9p-1VfkQ3Go~O-dNwh7XeknaHFNPqoUFxx03ALNFAU~9AwCaPCcE2c-Tvzt4DO-Q5aQoNECw5~AJJmLRtCqvKH1h6Eg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":116895,"name":"Hypoglycemia","url":"https://www.academia.edu/Documents/in/Hypoglycemia"},{"id":970066,"name":"Cerebral Blood Flow","url":"https://www.academia.edu/Documents/in/Cerebral_Blood_Flow"}],"urls":[{"id":38675435,"url":"https://www.nature.com/articles/s41598-020-77626-6.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113655883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113655883/ACTH_Dependent_Cushing_Syndrome_in_Metastatic_Acinic_Cell_Carcinoma_A_Poor_Prognostic_Factor"><img alt="Research paper thumbnail of ACTH-Dependent Cushing Syndrome in Metastatic Acinic Cell Carcinoma: A Poor Prognostic Factor" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113655883/ACTH_Dependent_Cushing_Syndrome_in_Metastatic_Acinic_Cell_Carcinoma_A_Poor_Prognostic_Factor">ACTH-Dependent Cushing Syndrome in Metastatic Acinic Cell Carcinoma: A Poor Prognostic Factor</a></div><div class="wp-workCard_item"><span>Annals of Internal Medicine: Clinical Cases</span><span>, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113655883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113655883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113655883; 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The phe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. The phenotypic effect of a recently discovered hyper-functional ADCY6 S674 variant is unclear. 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